#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14642	uniprotkb:P08567	intact:EBI-8670520|ensembl:ENSP00000357583|uniprotkb:Q14640|intact:UNK-5392019|uniprotkb:Q5JSF1|uniprotkb:D3DXI3	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	psi-mi:i5p1_human(display_long)|uniprotkb:43 kDa inositol polyphosphate 5-phosphatase(gene name synonym)|uniprotkb:5PTASE(gene name synonym)|uniprotkb:Type I inositol 1,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:INPP5A(gene name)|psi-mi:INPP5A(display_short)	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Auethavekiat et al. (1997)	mint:MINT-8216768|pubmed:8999861|doi:10.1074/jbc.272.3.1786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8670515|mint:MINT-8216777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000068383(gene)|ensembl:ENST00000368594(transcript)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0042731"(PH domain binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR039737|reactome:R-HSA-1855183|refseq:NP_001307971.1|refseq:NP_005530.3|mint:MINT-8216779(identity)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)|mint:MINT-8216780(identity)	-	comment:mint|function:"Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction"	-	comment:homomint|comment:mint|figure legend:fig.3|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/17	2014/10/16	rogid:WggXPOR+hZ/sOcfwveU1ErIdLS09606	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	intact-crc:6A089DAEF962D318|rigid:C23i9NDrfq+bTCv1Yy+HanR1xNo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14642	uniprotkb:P08567	intact:EBI-8670520|ensembl:ENSP00000357583|uniprotkb:Q14640|intact:UNK-5392019|uniprotkb:Q5JSF1|uniprotkb:D3DXI3	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	psi-mi:i5p1_human(display_long)|uniprotkb:43 kDa inositol polyphosphate 5-phosphatase(gene name synonym)|uniprotkb:5PTASE(gene name synonym)|uniprotkb:Type I inositol 1,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:INPP5A(gene name)|psi-mi:INPP5A(display_short)	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Auethavekiat et al. (1997)	mint:MINT-8216768|pubmed:8999861|doi:10.1074/jbc.272.3.1786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8670557|mint:MINT-8216788	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000068383(gene)|ensembl:ENST00000368594(transcript)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0042731"(PH domain binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR039737|reactome:R-HSA-1855183|refseq:NP_001307971.1|refseq:NP_005530.3|mint:MINT-8216790(identity)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)|mint:MINT-8216791(identity)	-	comment:mint|function:"Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction"	-	comment:homomint|comment:mint|figure legend:fig.3|partial coverage:partial coverage	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/17	2014/10/16	rogid:WggXPOR+hZ/sOcfwveU1ErIdLS09606	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	intact-crc:68FD9559E78E11BF|rigid:C23i9NDrfq+bTCv1Yy+HanR1xNo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14642	uniprotkb:P08567	intact:EBI-8670520|ensembl:ENSP00000357583|uniprotkb:Q14640|intact:UNK-5392019|uniprotkb:Q5JSF1|uniprotkb:D3DXI3	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	psi-mi:i5p1_human(display_long)|uniprotkb:43 kDa inositol polyphosphate 5-phosphatase(gene name synonym)|uniprotkb:5PTASE(gene name synonym)|uniprotkb:Type I inositol 1,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:INPP5A(gene name)|psi-mi:INPP5A(display_short)	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Auethavekiat et al. (1997)	mint:MINT-8216768|pubmed:8999861|doi:10.1074/jbc.272.3.1786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8670576|mint:MINT-8216799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000068383(gene)|ensembl:ENST00000368594(transcript)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0042731"(PH domain binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR039737|reactome:R-HSA-1855183|refseq:NP_001307971.1|refseq:NP_005530.3|mint:MINT-8216801(identity)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)|mint:MINT-8216802(identity)	-	comment:mint|function:"Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction"	-	comment:homomint|comment:mint|figure legend:fig.4|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/17	2014/10/16	rogid:WggXPOR+hZ/sOcfwveU1ErIdLS09606	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	intact-crc:2880A06AE51E17B5|rigid:C23i9NDrfq+bTCv1Yy+HanR1xNo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14642	uniprotkb:P08567	intact:EBI-8670520|ensembl:ENSP00000357583|uniprotkb:Q14640|intact:UNK-5392019|uniprotkb:Q5JSF1|uniprotkb:D3DXI3	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	psi-mi:i5p1_human(display_long)|uniprotkb:43 kDa inositol polyphosphate 5-phosphatase(gene name synonym)|uniprotkb:5PTASE(gene name synonym)|uniprotkb:Type I inositol 1,4,5-trisphosphate 5-phosphatase(gene name synonym)|uniprotkb:INPP5A(gene name)|psi-mi:INPP5A(display_short)	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Auethavekiat et al. (1997)	mint:MINT-8216768|pubmed:8999861|doi:10.1074/jbc.272.3.1786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8670595|mint:MINT-8216808	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000068383(gene)|ensembl:ENST00000368594(transcript)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0042731"(PH domain binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR039737|reactome:R-HSA-1855183|refseq:NP_001307971.1|refseq:NP_005530.3|mint:MINT-8216810(identity)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)|mint:MINT-8216811(identity)	-	comment:mint|function:"Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction"	-	comment:homomint|comment:mint|figure legend:fig.5|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/17	2014/10/16	rogid:WggXPOR+hZ/sOcfwveU1ErIdLS09606	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	intact-crc:3E84EB2B5D752151|rigid:C23i9NDrfq+bTCv1Yy+HanR1xNo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)