#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08721	uniprotkb:P29288	intact:EBI-8647328|ensembl:ENSRNOP00000062358|ensembl:ENSRNOP00000068511|intact:MINT-8283233	intact:EBI-8647267|ensembl:ENSRNOP00000066364|intact:MINT-8283229	psi-mi:ostp_rat(display_long)|uniprotkb:Spp1(gene name)|psi-mi:Spp1(display_short)|uniprotkb:2b7(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Spp-1(gene name synonym)	psi-mi:ppa5_rat(display_long)|uniprotkb:Acp5(gene name)|psi-mi:Acp5(display_short)|uniprotkb:Tartrate-resistant acid ATPase(gene name synonym)|uniprotkb:Type 5 acid phosphatase(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Ek-Rylander et al. (1994)	mint:MINT-8277121|pubmed:8195113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8647300|mint:MINT-8287613	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768218.1|ensembl:ENSRNOG00000043451(gene)|ensembl:ENSRNOT00000067875(transcript)|ensembl:ENSRNOT00000075989(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0010033"(response to organic substance)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031982"(vesicle)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042995"(cell projection)|go:"GO:0045177"(apical part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072044"(collecting duct development)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|reactome:R-RNO-1474228|reactome:R-RNO-186797|reactome:R-RNO-216083|reactome:R-RNO-381426|reactome:R-RNO-8957275|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_037013.2|rgd:3752|mint:MINT-8287617(identity)	ensembl:ENSRNOG00000046261(gene)|ensembl:ENSRNOT00000075237(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070723"(response to cholesterol)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR024927|interpro:IPR029052|rcsb pdb:1QFC|rcsb pdb:1QHW|reactome:R-RNO-196843|refseq:NP_062017.2|refseq:NP_001257818.1|rgd:2022|refseq:XP_006242754.1|refseq:XP_006242755.1|refseq:XP_006242756.1|mint:MINT-8287615(identity)	-	comment:mint|comment:homomint	comment:mint|comment:homomint	comment:homomint|comment:mint|figure legend:F1;F2;T1|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/04	2014/10/16	rogid:QJUU2DuPBFKqAzRphIqqY3SsgOc10116	rogid:dGRPRPIOtrL39seH4ka0KmH8myQ10116	intact-crc:D5A1FC10D984AEBF|rigid:tFYHQI3lURehSABWOAM76vuKlgY	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P08721	uniprotkb:Q61711	intact:EBI-8647328|ensembl:ENSRNOP00000062358|ensembl:ENSRNOP00000068511|intact:MINT-8283233	intact:EBI-8647305|ensembl:ENSMUSP00000031246|uniprotkb:Q61363|uniprotkb:Q80VR6|intact:MINT-8283231	psi-mi:ostp_rat(display_long)|uniprotkb:Spp1(gene name)|psi-mi:Spp1(display_short)|uniprotkb:2b7(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Spp-1(gene name synonym)	psi-mi:sial_mouse(display_long)|uniprotkb:Ibsp(gene name)|psi-mi:Ibsp(display_short)|uniprotkb:Bone sialoprotein II(gene name synonym)|uniprotkb:Cell-binding sialoprotein(gene name synonym)|uniprotkb:Integrin-binding sialoprotein(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Ek-Rylander et al. (1994)	mint:MINT-8277121|pubmed:8195113	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8647300|mint:MINT-8287613	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008768218.1|ensembl:ENSRNOG00000043451(gene)|ensembl:ENSRNOT00000067875(transcript)|ensembl:ENSRNOT00000075989(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0010033"(response to organic substance)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031982"(vesicle)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042995"(cell projection)|go:"GO:0045177"(apical part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072044"(collecting duct development)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|reactome:R-RNO-1474228|reactome:R-RNO-186797|reactome:R-RNO-216083|reactome:R-RNO-381426|reactome:R-RNO-8957275|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_037013.2|rgd:3752|mint:MINT-8287617(identity)	ensembl:ENSMUSG00000029306(gene)|ensembl:ENSMUST00000031246(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0031982"(vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR008412(Bone sialoprotein II)|reactome:R-MMU-216083|refseq:NP_032344.2|mint:MINT-8287616(identity)	-	comment:mint|comment:homomint	comment:mint|comment:homomint	comment:homomint|comment:mint|figure legend:F1;F2;T1|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/04	2014/10/16	rogid:QJUU2DuPBFKqAzRphIqqY3SsgOc10116	rogid:DQHT4vlWTg89LJ+1L9BAB19nuRo10090	intact-crc:D5A1FC10D984AEBF|rigid:tFYHQI3lURehSABWOAM76vuKlgY	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)