#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08559	uniprotkb:Q9P0J1	intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382	intact:EBI-2861634|uniprotkb:B3KX71|uniprotkb:Q5U5K1|uniprotkb:J3KPU0|ensembl:ENSP00000297598|ensembl:ENSP00000428317|ensembl:ENSP00000430380	psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:pdp1_human(display_long)|uniprotkb:PDP1(gene name)|psi-mi:PDP1(display_short)|uniprotkb:PDP(gene name synonym)|uniprotkb:PPM2C(gene name synonym)|uniprotkb:Protein phosphatase 2C(gene name synonym)|uniprotkb:Pyruvate dehydrogenase phosphatase catalytic subunit 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Korotchkina et al. (1995)	mint:MINT-8226367|pubmed:7782287|doi:10.1074/jbc.270.24.14297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8617220|mint:MINT-8227761	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N|mint:MINT-8227764(identity)	refseq:XP_011515438.1|refseq:NP_001155251.1|refseq:NP_001155252.1|refseq:NP_001155253.1|refseq:NP_060914.2|ensembl:ENSG00000164951(gene)|ensembl:ENST00000297598(transcript)|ensembl:ENST00000517764(transcript)|ensembl:ENST00000520728(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004741"("[pyruvate dehydrogenase (lipoamide)] phosphatase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:1904184"(positive regulation of pyruvate dehydrogenase activity)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|reactome:R-HSA-204174|go:"GO:0005739"(mitochondrion)|mint:MINT-8227763(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig.6	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/19	2014/10/16	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rogid:IXJq+qtJ0oAoODs/pXB1/NehhRY9606	intact-crc:275AC692D1F183BF|rigid:5kfQo//6RrVDLiJvDa0t97hC3KM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15118	uniprotkb:P08559	intact:EBI-7016221|uniprotkb:B7Z937|uniprotkb:E9PD65|uniprotkb:Q308M4|ensembl:ENSP00000282077|ensembl:ENSP00000386985|uniprotkb:B2R6T1|intact:MINT-2881420|uniprotkb:D3DPD8	intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382	psi-mi:pdk1_human(display_long)|uniprotkb:PDK1(gene name)|psi-mi:PDK1(display_short)|uniprotkb:PDHK1(gene name synonym)|uniprotkb:Pyruvate dehydrogenase kinase isoform 1(gene name synonym)	psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Korotchkina et al. (1995)	mint:MINT-8226367|pubmed:7782287|doi:10.1074/jbc.270.24.14297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8617229|mint:MINT-8227846	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29497N|ensembl:ENSG00000152256(gene)|ensembl:ENST00000282077(transcript)|ensembl:ENST00000410055(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q15118|rcsb pdb:2Q8F|rcsb pdb:2Q8G|rcsb pdb:2Q8H|reactome:R-HSA-204174|reactome:R-HSA-5362517|refseq:NP_002601.1|refseq:NP_001265478.1|mint:MINT-8227849(identity)	refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N|mint:MINT-8227848(identity)	-	comment:mint|comment:homomint|function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism	-	comment:homomint|comment:mint|figure legend:fig.5	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/19	2014/10/16	rogid:bGVYvRnjKgE4fa6X5wY5SveeIUM9606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	intact-crc:083270F2996809BF|rigid:5yIfU+EHksDBhOZeJEjEeH7GdVI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)