#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17283"	uniprotkb:Q9HBF4	intact:EBI-1257113	intact:EBI-4401611|uniprotkb:Q8WYX7|uniprotkb:Q96K57|uniprotkb:Q9BXP9|uniprotkb:Q9HCI3|uniprotkb:J3KNL9|ensembl:ENSP00000450742	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zfyv1_human(display_long)|uniprotkb:ZFYVE1(gene name)|psi-mi:ZFYVE1(display_short)|uniprotkb:DFCP1(gene name synonym)|uniprotkb:KIAA1589(gene name synonym)|uniprotkb:TAFF1(gene name synonym)|uniprotkb:ZNFN2A1(gene name synonym)|uniprotkb:Double FYVE-containing protein 1(gene name synonym)|uniprotkb:SR3(gene name synonym)|uniprotkb:Tandem FYVE fingers-1(gene name synonym)|uniprotkb:PP10436(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404564|imex:IM-15829-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016876862.1|refseq:NP_067083.1|refseq:NP_848535.1|refseq:NP_001268663.1|refseq:NP_001268664.1|ensembl:ENSG00000165861(gene)|ensembl:ENST00000556143(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005811"(lipid droplet)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016236"(macroautophagy)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990462"(omegasome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR027417|interpro:IPR042427	-	-	-	figure legend:Fig. 4, Supporting Information Table 3|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.25x10^-7(molar)	2011/09/14	2014/10/16	-	rogid:RjtNZQqOYzwdILGqkyavUWHPB5Q9606	intact-crc:81FE06C77FD0D28F	false	biotin tag:?-?	sufficient binding region:715-777(IPR000306)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:Q96BR1	intact:EBI-1257113	intact:EBI-2801236|uniprotkb:A8K5W3|uniprotkb:Q9UKG5|uniprotkb:Q9P1Q7|uniprotkb:B3KQC2|ensembl:ENSP00000331816|ensembl:ENSP00000379842|ensembl:ENSP00000430256|ensembl:ENSP00000430463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgk3_human(display_long)|uniprotkb:SGKL(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 3(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase-like(gene name synonym)|uniprotkb:SGK3(gene name)|psi-mi:SGK3(display_short)|uniprotkb:CISK(gene name synonym)|uniprotkb:Cytokine-independent survival kinase(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404586|imex:IM-15829-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028750.1|refseq:NP_001191102.1|refseq:NP_037389.4|refseq:NP_733827.2|ensembl:ENSG00000104205(gene)|ensembl:ENST00000345714(transcript)|ensembl:ENST00000521198(transcript)|ensembl:ENST00000522398(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|ensembl:ENST00000396596(transcript)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001683(Phox-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR036871|interpro:IPR037709|interpro:IPR037900|mint:Q96BR1|rcsb pdb:6EDX|reactome:R-HSA-2672351|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Fig. 5, Supp. Table 4|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-8(molar)	2011/09/14	2014/10/16	-	rogid:H3ibqrLkptVGc+FDFmEiMSyKhts9606	intact-crc:BD6642B309FDFE9E	false	biotin tag:?-?	sufficient binding region:12-124(IPR001683)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:Q13596	intact:EBI-1257113	intact:EBI-2822329|uniprotkb:O60750|uniprotkb:A8K6T7|uniprotkb:A6NM19|uniprotkb:O60751|uniprotkb:H0Y2M5|uniprotkb:Q6ZRJ8|ensembl:ENSP00000453785	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx1_human(display_long)|uniprotkb:SNX1(gene name)|psi-mi:SNX1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6558957|imex:IM-15829-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003090.2|refseq:NP_683758.1|refseq:NP_001229862.1|ensembl:ENSG00000028528(gene)|ensembl:ENST00000559844(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028660|interpro:IPR034901|mint:Q13596|rcsb pdb:2I4K|rcsb pdb:4FZS|interpro:IPR036871|dip:DIP-398N	-	-	-	figure legend:Fig. 5E|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:nFyxCtQ9gHndLbuCjBiwhyWE5do9606	intact-crc:368D50B6FC7838C9	false	biotin tag:?-?	sufficient binding region:143-272(IPR001683)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:Q96TA1	intact:EBI-1257113	intact:EBI-2514593|uniprotkb:Q4LE55|uniprotkb:Q5VVW7|intact:EBI-28984656|ensembl:ENSP00000362409|uniprotkb:Q9NT35|uniprotkb:Q9BUS2|uniprotkb:Q5VVW6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:niba2_human(display_long)|uniprotkb:NIBAN2(gene name)|psi-mi:NIBAN2(display_short)|uniprotkb:C9orf88(gene name synonym)|uniprotkb:FAM129B(gene name synonym)|uniprotkb:Meg-3(gene name synonym)|uniprotkb:Melanoma invasion by ERK(gene name synonym)|uniprotkb:Niban-like protein 1(gene name synonym)|uniprotkb:Protein FAM129B(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6558969|imex:IM-15829-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026088|mint:Q96TA1|rcsb pdb:7CTP|ensembl:ENSG00000136830(gene)|ensembl:ENST00000373312(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007411"(axon guidance)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032274"(gonadotropin secretion)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0045296"(cadherin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|refseq:NP_001030611.1|refseq:NP_073744.2|ensembl:ENSP00000362409|ensembl:ENST00000373314|ensembl:ENSP00000362411	-	-	-	figure legend:Fig. 5E|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:xdcw2BLz6uu0zyGi/NzvzPLrKUk9606	intact-crc:358E9F3CDF7FCF5E	false	biotin tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:55-179(IPR001849)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:O14964	intact:EBI-1257113	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404551|imex:IM-15829-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:Fig. 5A, Supporting Information Table 4|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-8(molar)	2011/09/14	2014/10/16	-	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	intact-crc:4ECB67A449B032ED	false	biotin tag:?-?	sufficient binding region:151-220(IPR011011)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:Q96M96	intact:EBI-1257113	intact:EBI-4401039|uniprotkb:Q6ULS2|uniprotkb:Q8TCP6|ensembl:ENSP00000394487|ensembl:ENSP00000433666|ensembl:ENSP00000462623	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fgd4_human(display_long)|uniprotkb:FGD4(gene name)|psi-mi:FGD4(display_short)|uniprotkb:FRABP(gene name synonym)|uniprotkb:ZFYVE6(gene name synonym)|uniprotkb:Actin filament-binding protein frabin(gene name synonym)|uniprotkb:FGD1-related F-actin-binding protein(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404576|imex:IM-15829-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_640334.2|refseq:NP_001291409.1|refseq:XP_011518857.1|refseq:XP_011518858.1|refseq:NP_001317303.1|refseq:NP_001317302.1|ensembl:ENSG00000139132(gene)|ensembl:ENST00000427716(transcript)|ensembl:ENST00000525053(transcript)|ensembl:ENST00000583694(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035899|interpro:IPR035941|interpro:IPR037742|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-9013148|interpro:IPR017455(Zinc finger, FYVE-related)	-	-	-	figure legend:Fig. 5D|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.95x10^-7(molar)	2011/09/14	2014/10/16	-	rogid:K4gzeBUhltm9N1SSPFdtgrmYsu89606	intact-crc:92F7C8B7C8EC65A5	false	biotin tag:?-?	sufficient binding region:559-619(IPR000306)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17283"	uniprotkb:O95229	intact:EBI-1257113	intact:EBI-1001132|uniprotkb:Q9BWD0|ensembl:ENSP00000363055|ensembl:ENSP00000378801|uniprotkb:Q0D2I3|uniprotkb:A6NNV6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zwint_human(display_long)|uniprotkb:ZW10-interacting protein 1(gene name synonym)|uniprotkb:ZWINT(gene name)|psi-mi:ZWINT(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001005413.1|refseq:NP_008988.2|refseq:NP_127490.1|go:"GO:0030425"(dendrite)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|ensembl:ENSG00000122952(gene)|go:"GO:0051649"(establishment of localization in cell)|interpro:IPR029092|ensembl:ENST00000373944(transcript)|ensembl:ENST00000395405(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|mint:O95229|go:"GO:0005737"(cytoplasm)|reactome:R-HSA-141444|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-2467813|go:"GO:0016604"(nuclear body)|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iQ5h+pikwo8Yu1MnEjxLtkGg1NE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43264	intact:EBI-1257113	intact:EBI-1001217|ensembl:ENSP00000200135|uniprotkb:A1A528	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zw10_human(display_long)|uniprotkb:ZW10(gene name)|psi-mi:ZW10(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004715.1|ensembl:ENSG00000086827(gene)|ensembl:ENST00000200135(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070939"(Dsl1/NZR complex)|go:"GO:1990423"(RZZ complex)|interpro:IPR009361(Centromerekinetochore Zw10)|mint:O43264|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-36471N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yqOV+ZYOLEPClJbYtPp9Jvlhyvc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H900	intact:EBI-1257113	intact:EBI-1001239|uniprotkb:Q6N049|uniprotkb:Q96SY7|uniprotkb:Q9NWG7|uniprotkb:Q8N404|uniprotkb:B3KVB8|ensembl:ENSP00000311429	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zwilc_human(display_long)|uniprotkb:ZWILCH(gene name)|psi-mi:ZWILCH(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060445.3|refseq:NP_001274750.1|refseq:NP_001274751.1|refseq:NP_001274752.1|dip:DIP-36478N|ensembl:ENSG00000174442(gene)|ensembl:ENST00000307897(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005829"(cytosol)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|go:"GO:1990423"(RZZ complex)|interpro:IPR018630|rcsb pdb:3IF8|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pIk5I4Y9Qk7AxO0KhWURdlvUu/Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35813	intact:EBI-1257113	intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62070	intact:EBI-1257113	intact:EBI-491037|uniprotkb:P17082|uniprotkb:B2R9Z3|uniprotkb:B7Z6C4|uniprotkb:B7Z7H6|ensembl:ENSP00000256196|uniprotkb:B7Z5Z2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rras2_human(display_long)|uniprotkb:Ras-like protein TC21(gene name synonym)|uniprotkb:Teratocarcinoma oncogene(gene name synonym)|uniprotkb:RRAS2(gene name)|psi-mi:RRAS2(display_short)|uniprotkb:TC21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036382.2|refseq:NP_001096139.1|refseq:NP_001170786.1|refseq:NP_001170785.1|ensembl:ENSG00000133818(gene)|ensembl:ENST00000256196(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:2ERY|reactome:R-HSA-9696273	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13315	intact:EBI-1257113	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IXI2	intact:EBI-1257113	intact:EBI-1396430|uniprotkb:A4FVB6|uniprotkb:Q6NUR3|uniprotkb:Q6P9F8|uniprotkb:Q6PJG1|uniprotkb:Q6YMW8|uniprotkb:Q86UB0|uniprotkb:Q8IW28|uniprotkb:Q8IXJ7|uniprotkb:Q9H067|uniprotkb:Q9H9N8|uniprotkb:Q9NUZ2|uniprotkb:A6NFV0|uniprotkb:B4DG48|uniprotkb:J9JIH9|ensembl:ENSP00000334724	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:miro1_human(display_long)|uniprotkb:Ras homolog gene family member T1(gene name synonym)|uniprotkb:Rac-GTP-binding protein-like protein(gene name synonym)|uniprotkb:RHOT1(gene name)|psi-mi:RHOT1(display_short)|uniprotkb:ARHT1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028738.1|refseq:NP_001028740.1|refseq:NP_060777.3|refseq:NP_001028739.2|refseq:NP_001275683.1|refseq:NP_001275684.1|refseq:NP_001275687.1|dip:DIP-39114N|ensembl:ENSG00000126858(gene)|ensembl:ENST00000333942(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0034640"(establishment of mitochondrion localization by microtubule attachment)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|interpro:IPR029506|mint:Q8IXI2|rcsb pdb:5KSO|rcsb pdb:5KSP|rcsb pdb:5KSY|rcsb pdb:5KSZ|rcsb pdb:5KTY|rcsb pdb:5KU1|rcsb pdb:6D71|reactome:R-HSA-5689880|reactome:R-HSA-9013425	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gA6A8bgSwshvMwCO0cG66h+wwIY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q08AM6	intact:EBI-1257113	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7LBR1	intact:EBI-1257113	intact:EBI-2118090|uniprotkb:Q96E89|uniprotkb:Q9HD41|ensembl:ENSP00000432279	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chm1b_human(display_long)|uniprotkb:CHMP1B(gene name)|psi-mi:CHMP1B(display_short)|uniprotkb:C18orf2(gene name synonym)|uniprotkb:Chromatin-modifying protein 1b(gene name synonym)|uniprotkb:CHMP1.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065145.2|ensembl:ENSP00000432279|dip:DIP-48534N|ensembl:ENSG00000255112(gene)|ensembl:ENST00000526991(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q7LBR1|rcsb pdb:3EAB|rcsb pdb:3JC1|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZ9	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JBzgWtpzZ/td6JuSSCIx5xpZE7M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IXI1	intact:EBI-1257113	intact:EBI-1396563|uniprotkb:Q8NF53|uniprotkb:Q96C13|uniprotkb:Q96S17|uniprotkb:Q9BT60|uniprotkb:Q9H7M8|uniprotkb:A2IDC2|ensembl:ENSP00000321971	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:miro2_human(display_long)|uniprotkb:RHOT2(gene name)|psi-mi:RHOT2(display_short)|uniprotkb:ARHT2(gene name synonym)|uniprotkb:C16orf39(gene name synonym)|uniprotkb:Ras homolog gene family member T2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_620124.1|ensembl:ENSG00000140983(gene)|ensembl:ENST00000315082(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|mint:Q8IXI1|rcsb pdb:5KUT|reactome:R-HSA-9013419	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E+WoN8aoND+U/YkLBUTecrNbDXg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NZM1	intact:EBI-1257113	intact:EBI-1994363|uniprotkb:Q5VWW2|uniprotkb:Q5VWW3|uniprotkb:Q5VWW4|uniprotkb:Q5VWW5|uniprotkb:Q7Z642|uniprotkb:Q8IWH0|uniprotkb:Q9HBU3|uniprotkb:Q9NZM0|uniprotkb:Q9ULL3|uniprotkb:Q9Y4U4|uniprotkb:B3KQN5|ensembl:ENSP00000352208	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:myof_human(display_long)|uniprotkb:MYOF(gene name)|psi-mi:MYOF(display_short)|uniprotkb:KIAA1207(gene name synonym)|uniprotkb:FER1L3(gene name synonym)|uniprotkb:Fer-1-like protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_038479.1|refseq:NP_579899.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029999|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9NZM1|rcsb pdb:2DMH|rcsb pdb:2K2O|rcsb pdb:6EEL|ensembl:ENSG00000138119(gene)|ensembl:ENST00000359263(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006936"(muscle contraction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008015"(blood circulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0061025"(membrane fusion)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YbWzqcootZO0/w6OLRqxZEEAu9U9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62834	intact:EBI-1257113	intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63096	intact:EBI-1257113	intact:EBI-618639|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|uniprotkb:P04898|uniprotkb:P11015|uniprotkb:P31871|uniprotkb:Q5U074|uniprotkb:Q8TAN5|uniprotkb:Q9UGA4|uniprotkb:A8KA88|uniprotkb:B4E2V1|uniprotkb:C9J3A4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gnai1_human(display_long)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-418597|reactome:R-HSA-422356|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-418594|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENSG00000127955(gene)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P63096|rcsb pdb:1KJY|rcsb pdb:1Y3A|rcsb pdb:2G83|rcsb pdb:2GTP|rcsb pdb:2IK8|rcsb pdb:2OM2|rcsb pdb:2XNS|rcsb pdb:3ONW|rcsb pdb:3QE0|rcsb pdb:3QI2|rcsb pdb:3UMR|rcsb pdb:3UMS|rcsb pdb:4G5Q|rcsb pdb:5JS7|rcsb pdb:5JS8|rcsb pdb:5TDH|rcsb pdb:6CMO|rcsb pdb:6CRK|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6KPF|rcsb pdb:6KPG|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LML|rcsb pdb:6N4B|rcsb pdb:6OMM|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6QNO|rcsb pdb:6VU8|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7EB2|rcsb pdb:7JVR|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7O7F|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-400042|reactome:R-HSA-418555|refseq:NP_002060.4|refseq:NP_001243343.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P13861	intact:EBI-1257113	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WVM7	intact:EBI-1257113	intact:EBI-1175097|uniprotkb:O00539|uniprotkb:Q6P275|intact:EBI-11027072|ensembl:ENSP00000372689	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stag1_human(display_long)|uniprotkb:STAG1(gene name)|psi-mi:STAG1(display_short)|uniprotkb:SA1(gene name synonym)|uniprotkb:Stromal antigen 1(gene name synonym)|uniprotkb:SCC3 homolog 1(gene name synonym)|uniprotkb:SCC3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005853.2|ensembl:ENSG00000118007(gene)|ensembl:ENST00000383202(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020839|interpro:IPR039662|mint:Q8WVM7|rcsb pdb:5QSM|rcsb pdb:5QSN|rcsb pdb:5QSO|rcsb pdb:5QSP|rcsb pdb:5QSQ|rcsb pdb:5QSR|rcsb pdb:5QSS|rcsb pdb:5QST|rcsb pdb:5QSU|rcsb pdb:5QSV|rcsb pdb:5QSW|rcsb pdb:5QSX|rcsb pdb:5QSY|rcsb pdb:5QSZ|rcsb pdb:6QB5|rcsb pdb:6R7O|rcsb pdb:6RRC|rcsb pdb:6RRK|rcsb pdb:6WG3|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR013721(STAG)|dip:DIP-35421N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:rg5wj0+iyr44mtRMgE12tD8X5LY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15041	intact:EBI-1257113	intact:EBI-714543|ensembl:ENSP00000306788|uniprotkb:B7Z6S5|uniprotkb:B7Z791|uniprotkb:F5GXP4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ar6p1_human(display_long)|uniprotkb:ARL6IP(gene name synonym)|uniprotkb:ARL6IP1(gene name)|psi-mi:ARL6IP1(display_short)|uniprotkb:KIAA0069(gene name synonym)|uniprotkb:ARMER(gene name synonym)|uniprotkb:Apoptotic regulator in the membrane of the endoplasmic reticulum(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055976.1|ensembl:ENSG00000170540(gene)|ensembl:ENST00000304414(transcript)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|interpro:IPR033301|mint:Q15041|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|refseq:NP_001300787.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3fjkoyvUx25po7xsPcXgpjEeLJg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00139	intact:EBI-1257113	intact:EBI-2692369|uniprotkb:A5YM42|uniprotkb:Q7Z5I3|uniprotkb:B4DY54|uniprotkb:A5YM54|uniprotkb:Q8N5Q7|uniprotkb:D3DW97|uniprotkb:E9PB70|ensembl:ENSP00000385622	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kif2a_human(display_long)|uniprotkb:KIF2(gene name synonym)|uniprotkb:KNS2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)|uniprotkb:KIF2A(gene name)|psi-mi:KIF2A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001091981.1|refseq:NP_004511.2|refseq:NP_001230881.1|ensembl:ENSG00000068796(gene)|ensembl:ENST00000401507(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:O00139|rcsb pdb:2GRY|rcsb pdb:6BBN|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189|dip:DIP-56112N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XuuV3xe7NwfZMTlyNE5I2mlgDVo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13164	intact:EBI-1257113	intact:EBI-1213983|uniprotkb:Q16634|uniprotkb:Q59F50|uniprotkb:Q6QLU7|uniprotkb:Q7L4P4|uniprotkb:Q969G1|uniprotkb:Q96G51|intact:EBI-28979986|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk07_human(display_long)|uniprotkb:MAPK7(gene name)|psi-mi:MAPK7(display_short)|uniprotkb:BMK1(gene name synonym)|uniprotkb:ERK5(gene name synonym)|uniprotkb:PRKM7(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 5(gene name synonym)|uniprotkb:Big MAP kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002740.2|refseq:NP_620601.1|refseq:NP_620602.2|refseq:NP_620603.2|ensembl:ENST00000299612|ensembl:ENSP00000299612|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968|refseq:XP_011522259.1|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13164|rcsb pdb:2Q8Y|rcsb pdb:4B99|rcsb pdb:4IC7|rcsb pdb:4IC8|rcsb pdb:4ZSG|rcsb pdb:4ZSJ|rcsb pdb:4ZSL|rcsb pdb:5BYY|rcsb pdb:5BYZ|rcsb pdb:5O7I|rcsb pdb:6HKM|rcsb pdb:6HKN|reactome:R-HSA-198753|reactome:R-HSA-198765|reactome:R-HSA-202670|reactome:R-HSA-2559582|reactome:R-HSA-881907|reactome:R-HSA-8853659|ensembl:ENSG00000166484(gene)|ensembl:ENST00000308406(transcript)|ensembl:ENST00000395602(transcript)|ensembl:ENST00000395604(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030154"(cell differentiation)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dUTMnlgdjEkFhq0i6RmvpX5U7BM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P53990	intact:EBI-1257113	intact:EBI-945994|intact:EBI-4324656|uniprotkb:A8KAH5|uniprotkb:Q9BQ81|uniprotkb:Q9BWN2|uniprotkb:Q3SYM4|uniprotkb:J3QLU7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ist1_human(display_long)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Putative MAPK-activating protein PM28(gene name synonym)|uniprotkb:KIAA0174(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055576.2|refseq:NP_001257904.1|refseq:NP_001257906.1|refseq:NP_001257905.1|refseq:NP_001257907.1|mint:P53990|dip:DIP-42546N|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0009838"(abscission)|go:"GO:0015031"(protein transport)|go:"GO:0019076"(viral release from host cell)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046745"(viral capsid secondary envelopment)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0090543"(Flemming body)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3FRR|rcsb pdb:3FRS|rcsb pdb:3JC1|rcsb pdb:4U7E|rcsb pdb:4U7I|rcsb pdb:4U7Y|rcsb pdb:4WZX|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZA|reactome:R-HSA-6798695|reactome:R-HSA-9668328	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RbWwKZ+sftO2x3UkFz8zAxVi2CU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99747	intact:EBI-1257113	intact:EBI-3221833|uniprotkb:B4DFC9|ensembl:ENSP00000324628|uniprotkb:Q9BUV1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snag_human(display_long)|uniprotkb:NAPG(gene name)|psi-mi:NAPG(display_short)|uniprotkb:SNAPG(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134265(gene)|ensembl:ENST00000322897(transcript)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0045202"(synapse)|go:"GO:0050821"(protein stabilization)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q99747|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:XP_011524058.1|refseq:NP_003817.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QbHDxqDWn6/UYiMIOMiKfx5eCFg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75935	intact:EBI-1257113	intact:EBI-347442|uniprotkb:A6NII7|uniprotkb:Q5T1I5|uniprotkb:Q5T1I7|uniprotkb:Q5T8G3|uniprotkb:Q9BPU8|uniprotkb:B2RBM5|ensembl:ENSP00000259632	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dctn3_human(display_long)|uniprotkb:DCTN22(gene name synonym)|uniprotkb:DCTN3(gene name)|psi-mi:DCTN3(display_short)|uniprotkb:Dynactin complex subunit 22 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009165.1|refseq:NP_077324.1|ensembl:ENSG00000137100(gene)|ensembl:ENST00000259632(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|interpro:IPR009991(Dynactin subunit p22)|mint:O75935|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|refseq:NP_001268354.1|refseq:NP_001268355.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KPLiGDMa0KR/H31QtEdl2YiwYzk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q587I9	intact:EBI-1257113	intact:EBI-4402184|uniprotkb:Q8N2P9|ensembl:ENSP00000310803	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sft2c_human(display_long)|uniprotkb:SFT2D3(gene name)|psi-mi:SFT2D3(display_short)|uniprotkb:SFT2 domain-containing protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_116129.3|ensembl:ENSG00000173349(gene)|ensembl:ENST00000310981(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR007305(Got1-like protein)|interpro:IPR011691(SFT2-like)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:67ikROQfF/B2cBdjJzgCG+WG/U89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11802	intact:EBI-1257113	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00535	intact:EBI-1257113	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TDH9	intact:EBI-1257113	intact:EBI-465861|ensembl:ENSP00000380598|uniprotkb:Q0VDJ7|uniprotkb:Q5THS1|uniprotkb:Q68D56|uniprotkb:Q8N5F9|uniprotkb:Q9NU16|uniprotkb:B4DVM2|uniprotkb:Q0VDJ6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bl1s5_human(display_long)|uniprotkb:BLOC1S5(gene name)|psi-mi:BLOC1S5(display_short)|uniprotkb:MUTED(gene name synonym)|uniprotkb:Protein Muted homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000188428(gene)|ensembl:ENST00000397457(transcript)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0050942"(positive regulation of pigment cell differentiation)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR017243(BLOC-1 complex, muted subunit)|refseq:NP_958437.1|refseq:NP_001186251.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Bbv2N+NCAJ0baNXhhFYIsIqDwSg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35606	intact:EBI-1257113	intact:EBI-1056534|uniprotkb:B4DZI8|intact:EBI-11019844|ensembl:ENSP00000329419	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copb2_human(display_long)|uniprotkb:COPB2(gene name)|psi-mi:COPB2(display_short)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004757.1|ensembl:ENSG00000184432(gene)|ensembl:ENST00000333188(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:P35606|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_016863001.1|dip:DIP-27603N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zkd7lOeV+OvHglnAJg6cXoMhgbg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42858	intact:EBI-1257113	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P53618	intact:EBI-1257113	intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63208	intact:EBI-1257113	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14008	intact:EBI-1257113	intact:EBI-310585|uniprotkb:Q0VAX8|uniprotkb:Q14668|uniprotkb:Q05D70|uniprotkb:Q0VAX7|uniprotkb:Q2TA89|uniprotkb:Q6NSH4|intact:EBI-28968667|ensembl:ENSP00000432768	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ckap5_human(display_long)|uniprotkb:CKAP5(gene name)|psi-mi:CKAP5(display_short)|uniprotkb:KIAA0097(gene name synonym)|uniprotkb:Colonic and hepatic tumor overexpressed gene protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000312055|ensembl:ENSP00000310227|ensembl:ENST00000354558|ensembl:ENSP00000346566|ensembl:ENSP00000432768|refseq:NP_001008938.1|refseq:NP_055571.2|ensembl:ENSG00000175216(gene)|ensembl:ENST00000529230(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0050658"(RNA transport)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0090063"(positive regulation of microtubule nucleation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024395|interpro:IPR034085|mint:Q14008|rcsb pdb:4QMI|rcsb pdb:4QMJ|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3bgwyNEucxXwXdbxbJkJ07PC90w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43617	intact:EBI-1257113	intact:EBI-743566|uniprotkb:B2RDN2|uniprotkb:D3DPS2|uniprotkb:A6NDN0|ensembl:ENSP00000362261	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tppc3_human(display_long)|uniprotkb:BET3 homolog(gene name synonym)|uniprotkb:TRAPPC3(gene name)|psi-mi:TRAPPC3(display_short)|uniprotkb:BET3(gene name synonym)|uniprotkb:CDABP0066(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055223.1|refseq:NP_001257823.1|refseq:NP_001257824.1|refseq:NP_001257825.1|refseq:NP_001257826.1|ensembl:ENSG00000054116(gene)|ensembl:ENST00000373166(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:0033106"(cis-Golgi network membrane)|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|mint:O43617|rcsb pdb:1SZ7|rcsb pdb:2C0J|rcsb pdb:2CFH|rcsb pdb:3KXC|reactome:R-HSA-204005|reactome:R-HSA-8876198|dip:DIP-47627N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YEQWfs0KIBIDkvJ+2Xtz8afsDCc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13625	intact:EBI-1257113	intact:EBI-77642|uniprotkb:Q12892|uniprotkb:Q86X75|uniprotkb:Q96KQ3|uniprotkb:B4DG66	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aspp2_human(display_long)|uniprotkb:TP53BP2(gene name)|psi-mi:TP53BP2(display_short)|uniprotkb:ASPP2(gene name synonym)|uniprotkb:BBP(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 2(gene name synonym)|uniprotkb:Bcl2-binding protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-51(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001026855.2|refseq:NP_005417.1|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR029071|interpro:IPR036028|interpro:IPR036770|rcsb pdb:1YCS|rcsb pdb:2UWQ|rcsb pdb:4A63|rcsb pdb:4IRV|rcsb pdb:6GHM|rcsb pdb:6HKP|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803211|reactome:R-HSA-6804759|ensembl:ENST00000343537|ensembl:ENSP00000341957|ensembl:ENSG00000143514|ensembl:ENST00000391878|ensembl:ENSP00000375750|refseq:XP_011542571.1|dip:DIP-426N|mint:Q13625	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:p3shTkfKZ6Ipy/xOQok7jfGD9vg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15435	intact:EBI-1257113	intact:EBI-1024281|uniprotkb:Q9UQE5|uniprotkb:Q9UQE6|uniprotkb:Q9Y6K4|ensembl:ENSP00000234038|uniprotkb:B4DFD4|ensembl:ENSP00000385657|uniprotkb:B5MCY6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pp1r7_human(display_long)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:SDS22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000115685(gene)|refseq:NP_002703.1|ensembl:ENST00000234038(transcript)|ensembl:ENST00000407025(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|rcsb pdb:6HKW|rcsb pdb:6MKY|rcsb pdb:6OBN|rcsb pdb:6OBP|refseq:NP_001269338.1|refseq:NP_001269339.1|refseq:NP_001269340.1|refseq:NP_001269341.1|refseq:NP_001269342.1|refseq:NP_001269343.1|dip:DIP-1005N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HKHhTMtEgPpOdf/lS59bZAOrDjk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q29RF7	intact:EBI-1257113	intact:EBI-1175454|uniprotkb:Q2TTR5|uniprotkb:Q68DF7|uniprotkb:Q8N7J4|uniprotkb:Q8NG14|uniprotkb:Q9Y4D4|intact:EBI-2554552|ensembl:ENSP00000303427	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pds5a_human(display_long)|uniprotkb:Sister chromatid cohesion protein 112(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 54 protein(gene name synonym)|uniprotkb:PDS5A(gene name)|psi-mi:PDS5A(display_short)|uniprotkb:KIAA0648(gene name synonym)|uniprotkb:PDS5(gene name synonym)|uniprotkb:PIG54(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000121892(gene)|ensembl:ENST00000303538(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039776|mint:Q29RF7|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|go:"GO:0005829"(cytosol)|refseq:NP_001093869.1|refseq:NP_001093870.1|refseq:XP_011511974.1|refseq:XP_016863417.1|dip:DIP-35419N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PaZZmQCIaSIoxVpMuuERQbDLMpY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6IN85	intact:EBI-1257113	intact:EBI-1055598|uniprotkb:Q69YK6|uniprotkb:Q86U23|uniprotkb:Q86YI7|uniprotkb:Q8IVG1|uniprotkb:Q9H3F1|uniprotkb:Q9H7U8|uniprotkb:Q9NV01|uniprotkb:Q9NWP1|ensembl:ENSP00000450883	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p4r3a_human(display_long)|uniprotkb:PPP4R3A(gene name)|psi-mi:PPP4R3A(display_short)|uniprotkb:KIAA2010(gene name synonym)|uniprotkb:PP4R3A(gene name synonym)|uniprotkb:SMEK homolog 1(gene name synonym)|uniprotkb:SMEK1(gene name synonym)|uniprotkb:MSTP033(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001271209.1|refseq:NP_001271210.1|refseq:XP_005267899.1|ensembl:ENSG00000100796(gene)|ensembl:ENST00000554943(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|interpro:IPR006887(Protein of unknown function DUF625)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:6R8I	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/Tc381stK9K9hy3AKtl1yNv9ajA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHQ4	intact:EBI-1257113	intact:EBI-2548400|ensembl:ENSP00000005259|ensembl:ENSP00000368412|ensembl:ENSP00000490977|ensembl:ENSP00000491801|uniprotkb:O95003|uniprotkb:G5E9L4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bap29_human(display_long)|uniprotkb:BCAP29(gene name)|psi-mi:BCAP29(display_short)|uniprotkb:BAP29(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514708.1|ensembl:ENSG00000075790(gene)|ensembl:ENSG00000283852(gene)|ensembl:ENST00000005259(transcript)|ensembl:ENST00000379117(transcript)|ensembl:ENST00000640518(transcript)|ensembl:ENST00000640915(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:Q9UHQ4|rcsb pdb:4W7Y|rcsb pdb:4W7Z|rcsb pdb:4W80|refseq:NP_061332.2|refseq:XP_006716114.1|refseq:NP_001008405.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:s9pfUcldGnUfE6PBHYuZB9dqjGE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P0C869	intact:EBI-1257113	intact:EBI-2804040|uniprotkb:Q9UKV7|uniprotkb:Q8TB10|uniprotkb:Q59GF9|uniprotkb:O95712|uniprotkb:B4DRT9|uniprotkb:Q19KD5|uniprotkb:Q19KD6|ensembl:ENSP00000396045|ensembl:ENSP00000416610	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pa24b_human(display_long)|uniprotkb:Phospholipase A2 group IVB(gene name synonym)|uniprotkb:Lysophospholipase A1 group IVB(gene name synonym)|uniprotkb:PLA2G4B(gene name)|psi-mi:PLA2G4B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001108105.1|refseq:NP_001185517.1|refseq:NP_005081.1|ensembl:ENSG00000243708(gene)|ensembl:ENST00000452633(transcript)|ensembl:ENST00000458483(transcript)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007567"(parturition)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031901"(early endosome membrane)|go:"GO:0036148"(phosphatidylglycerol acyl-chain remodeling)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0036152"(phosphatidylethanolamine acyl-chain remodeling)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR040723|interpro:IPR041847|reactome:R-HSA-1482788|reactome:R-HSA-1482801|reactome:R-HSA-1482839|reactome:R-HSA-1482925|reactome:R-HSA-1483115|reactome:R-HSA-1483166|reactome:R-HSA-381038	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:w52t9oqd5SGfaVRPr03tr7uF0M49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6NUQ1	intact:EBI-1257113	intact:EBI-726876|uniprotkb:Q75MG9|uniprotkb:Q75MH0|uniprotkb:Q96IW8|uniprotkb:Q9H229|uniprotkb:Q9HAD9|intact:EBI-28981798|ensembl:ENSP00000257700	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rint1_human(display_long)|uniprotkb:RAD50 interactor 1(gene name synonym)|uniprotkb:RINT1(gene name)|psi-mi:RINT1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000135249(gene)|ensembl:ENST00000257700(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0015031"(protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0070939"(Dsl1/NZR complex)|interpro:IPR007528(RINT-1/TIP-1)|interpro:IPR042044|reactome:R-HSA-6811434|refseq:NP_068749.3|ensembl:ENSP00000257700|dip:DIP-36477N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aUzUSBI8f6ednxeVnP97ifOMoPc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13526	intact:EBI-1257113	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7Z7K6	intact:EBI-1257113	intact:EBI-1210604|uniprotkb:Q3L8N5|uniprotkb:Q8NFH6|uniprotkb:B2RPK2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cenpv_human(display_long)|uniprotkb:CENPV(gene name)|psi-mi:CENPV(display_short)|uniprotkb:Nuclear protein p30(gene name synonym)|uniprotkb:PRR6(gene name synonym)|uniprotkb:Proline-rich protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_859067.2|interpro:IPR006913(Glutathione-dependent formaldehyde-activating, GFA)|interpro:IPR011057(Mss4-like)|mint:Q7Z7K6|go:"GO:0000776"(kinetochore)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016846"(carbon-sulfur lyase activity)|go:"GO:0030496"(midbody)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:q2Dt9PEcUigyqjqFMVm3dxk54B09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P287	intact:EBI-1257113	intact:EBI-711154|uniprotkb:B3KP45|ensembl:ENSP00000278100|uniprotkb:Q8ND15|uniprotkb:Q96GC4|uniprotkb:Q9P288	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bccip_human(display_long)|uniprotkb:Protein TOK-1(gene name synonym)|uniprotkb:BCCIP(gene name)|psi-mi:BCCIP(display_short)|uniprotkb:TOK1(gene name synonym)|uniprotkb:P21- and CDK-associated protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057651.1|refseq:NP_510868.1|refseq:NP_510869.1|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR025602|rcsb pdb:7KYQ|rcsb pdb:7KYS|ensembl:ENSG00000107949(gene)|ensembl:ENST00000278100(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0015631"(tubulin binding)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0061101"(neuroendocrine cell differentiation)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MIScu215hnD7OIjXEeYP6xPqIQs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NR31	intact:EBI-1257113	intact:EBI-3920694|uniprotkb:B4DQ19|ensembl:ENSP00000362335|ensembl:ENSP00000362338|ensembl:ENSP00000362339|ensembl:ENSP00000399698	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sar1a_human(display_long)|uniprotkb:SAR1A(gene name)|psi-mi:SAR1A(display_short)|uniprotkb:SAR1(gene name synonym)|uniprotkb:SARA(gene name synonym)|uniprotkb:SARA1(gene name synonym)|uniprotkb:COPII-associated small GTPase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000079332(gene)|ensembl:ENST00000373238(transcript)|ensembl:ENST00000373241(transcript)|ensembl:ENST00000373242(transcript)|ensembl:ENST00000431664(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016050"(vesicle organization)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0061024"(membrane organization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006687(GTP-binding protein SAR1)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:Q9NR31|rcsb pdb:2GAO|refseq:NP_001136120.1|refseq:NP_064535.1|dip:DIP-59790N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Wgq8eFE+YfSt/fs1cpGicDT0rMA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13561	intact:EBI-1257113	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99459	intact:EBI-1257113	intact:EBI-374880|uniprotkb:Q76N46|uniprotkb:Q99974|ensembl:ENSP00000360532	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdc5l_human(display_long)|uniprotkb:CDC5L(gene name)|psi-mi:CDC5L(display_short)|uniprotkb:Pombe cdc5-related protein(gene name synonym)|uniprotkb:KIAA0432(gene name synonym)|uniprotkb:PCDC5RP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|rcsb pdb:6ID1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071352"(cellular response to interleukin-2)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990646"(cellular response to prolactin)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q99459|rcsb pdb:2DIM|rcsb pdb:2DIN|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|ensembl:ENSG00000096401(gene)|ensembl:ENST00000371477(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|refseq:NP_001244.1|dip:DIP-31731N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZNRraJHn//46wKLSx7xtZju/lr09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95159	intact:EBI-1257113	intact:EBI-718439|uniprotkb:O14616|uniprotkb:Q9UID0|uniprotkb:A8K7E9|ensembl:ENSP00000294258	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zfpl1_human(display_long)|uniprotkb:Zinc finger protein MCG4(gene name synonym)|uniprotkb:ZFPL1(gene name)|psi-mi:ZFPL1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006773.2|ensembl:ENSG00000162300(gene)|ensembl:ENST00000294258(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039043|mint:O95159	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8U/G+YcD/pF1Cg44ghFOW+D8tD89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q969X5	intact:EBI-1257113	intact:EBI-781527|uniprotkb:Q9H0L0|uniprotkb:Q9H2J2|uniprotkb:Q9ULN9|ensembl:ENSP00000377374	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ergi1_human(display_long)|uniprotkb:ER-Golgi intermediate compartment 32 kDa protein(gene name synonym)|uniprotkb:ERGIC1(gene name)|psi-mi:ERGIC1(display_short)|uniprotkb:KIAA1181(gene name synonym)|uniprotkb:HT034(orf name)|uniprotkb:ERGIC32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006714955.1|refseq:NP_001026881.1|ensembl:ENSG00000113719(gene)|ensembl:ENST00000393784(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UbuPGmvwVwrwg/LT5oAn9pLs5Hw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46459	intact:EBI-1257113	intact:EBI-712251|ensembl:ENSP00000381293|ensembl:ENSP00000478614|ensembl:ENSP00000481714|uniprotkb:Q8N6D7|uniprotkb:Q9UKZ2|uniprotkb:A8K2D9|uniprotkb:B4DFA2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nsf_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:NSF(gene name)|psi-mi:NSF(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073969(gene)|ensembl:ENSG00000276262(gene)|ensembl:ENSG00000278174(gene)|ensembl:ENST00000398238(transcript)|ensembl:ENST00000611398(transcript)|ensembl:ENST00000620290(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46459|rcsb pdb:6KZQ|reactome:R-HSA-204005|reactome:R-HSA-416993|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_006169.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:J5hsoA0RTiQkWrV7nWpnK8Dvxxg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95347	intact:EBI-1257113	intact:EBI-355822|intact:EBI-1058371|uniprotkb:Q9P1P2|uniprotkb:Q6IEE0|ensembl:ENSP00000286398|ensembl:ENSP00000363919|ensembl:ENSP00000363925	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc2_human(display_long)|uniprotkb:PRO0324(orf name)|uniprotkb:SMC2(gene name)|psi-mi:SMC2(display_short)|uniprotkb:CAPE(gene name synonym)|uniprotkb:SMC2L1(gene name synonym)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036015.1|refseq:NP_001036016.1|refseq:NP_006435.2|refseq:XP_011516451.1|refseq:XP_011516455.1|refseq:XP_011516450.1|refseq:NP_001252531.1|refseq:XP_006716996.1|refseq:XP_016869695.1|refseq:XP_016869696.1|refseq:XP_016869697.1|dip:DIP-35422N|ensembl:ENSG00000136824(gene)|ensembl:ENST00000286398(transcript)|ensembl:ENST00000374787(transcript)|ensembl:ENST00000374793(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:O95347|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:k7RHRDmgiucuAOIfh8vjbqnlv3E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96JB2	intact:EBI-1257113	intact:EBI-2807756|ensembl:ENSP00000258654|uniprotkb:Q5VT70|uniprotkb:B2RAW5|uniprotkb:Q9BZ92|uniprotkb:Q8IXX4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cog3_human(display_long)|uniprotkb:COG3(gene name)|psi-mi:COG3(display_short)|uniprotkb:SEC34(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 3(gene name synonym)|uniprotkb:Vesicle-docking protein SEC34 homolog(gene name synonym)|uniprotkb:p94(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000136152(gene)|ensembl:ENST00000349995(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0050821"(protein stabilization)|interpro:IPR007265(Sec34-like protein)|mint:Q96JB2|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_113619.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:P3sc7TLrhgqNPIh7VYpmsoIhSrE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P24385	intact:EBI-1257113	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75582	intact:EBI-1257113	intact:EBI-73869|uniprotkb:O95316|uniprotkb:Q96AF7|uniprotkb:B7Z2Y5|intact:EBI-14183507|intact:EBI-12850788|ensembl:ENSP00000479667	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ks6a5_human(display_long)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 5(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)|uniprotkb:RPS6KA5(gene name)|psi-mi:RPS6KA5(display_short)|uniprotkb:MSK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004746.2|refseq:NP_872198.1|refseq:NP_001309164.1|refseq:NP_001309166.1|dip:DIP-30894N|ensembl:ENSG00000100784(gene)|ensembl:ENST00000614987(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0043990"(histone H2A-S1 phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:O75582|rcsb pdb:1VZO|rcsb pdb:3KN5|rcsb pdb:3KN6|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-5621575	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8W2PRa/aVTLxiBJEbbXoebPqlco9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IVM0-2	intact:EBI-1257113	intact:EBI-4402176|ensembl:ENSP00000376249	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q8ivm0-2(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:CCDC50(gene name)|psi-mi:CCDC50(display_short)|uniprotkb:C3orf6(gene name synonym)|uniprotkb:Protein Ymer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000152492(gene)|ensembl:ENST00000392455(transcript)|intact:EBI-723996(isoform-parent)|uniprotkb:Q8IVM0-2(isoform-parent)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3oRGEWBSvm/a3AUK/LVvtbp+lCg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TCY9	intact:EBI-1257113	intact:EBI-4402198|uniprotkb:Q658M4|uniprotkb:Q68DH6|uniprotkb:Q6MZZ5|uniprotkb:Q8WV98|uniprotkb:Q9NWR7|uniprotkb:Q9P221|uniprotkb:E9PFF6|ensembl:ENSP00000396918	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:urgcp_human(display_long)|uniprotkb:URGCP(gene name)|psi-mi:URGCP(display_short)|uniprotkb:KIAA1507(gene name synonym)|uniprotkb:URG4(gene name synonym)|uniprotkb:HBV X protein up-regulated gene 4 protein(gene name synonym)|uniprotkb:HBxAg up-regulated gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001277004.1|refseq:NP_001277005.1|refseq:NP_001071131.1|refseq:NP_001071132.1|refseq:NP_060390.3|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030383|mint:Q8TCY9|ensembl:ENSG00000106608(gene)|ensembl:ENST00000453200(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xoebsRj6/DnaJMLbRHX92DFt5709606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BPX3	intact:EBI-1257113	intact:EBI-970214|uniprotkb:Q9HBI9|ensembl:ENSP00000251496|uniprotkb:Q3MJE0|uniprotkb:Q96SV9|uniprotkb:Q9BUR3|uniprotkb:Q9BVY1|uniprotkb:Q9H914|uniprotkb:Q9H9Z6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cnd3_human(display_long)|uniprotkb:NCAPG(gene name)|psi-mi:NCAPG(display_short)|uniprotkb:NYMEL3(gene name synonym)|uniprotkb:CAPG(gene name synonym)|uniprotkb:Chromosome-associated protein G(gene name synonym)|uniprotkb:Condensin subunit CAP-G(gene name synonym)|uniprotkb:XCAP-G homolog(gene name synonym)|uniprotkb:Melanoma antigen NY-MEL-3(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000109805(gene)|ensembl:ENST00000251496(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025977|interpro:IPR027165|mint:Q9BPX3|rcsb pdb:6IGX|reactome:R-HSA-2514853|refseq:NP_071741.2|dip:DIP-34891N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:G45XQBcnTeSunRz57s6lJErxvjo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P06493	intact:EBI-1257113	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y282	intact:EBI-1257113	intact:EBI-781551|uniprotkb:Q6ZWP7|uniprotkb:Q9H276|uniprotkb:Q9P1L3|uniprotkb:Q5JWS3|ensembl:ENSP00000341358	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ergi3_human(display_long)|uniprotkb:Serologically defined breast cancer antigen NY-BR-84(gene name synonym)|uniprotkb:ERGIC3(gene name)|psi-mi:ERGIC3(display_short)|uniprotkb:C20orf47(gene name synonym)|uniprotkb:CGI-54(orf name)|uniprotkb:PRO0989(orf name)|uniprotkb:ERV46(gene name synonym)|uniprotkb:SDBCAG84(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057050.1|refseq:NP_938408.1|ensembl:ENSG00000125991(gene)|ensembl:ENST00000348547(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|mint:Q9Y282	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LllzE6k0eaM1uUJGjkieiPARw149606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NUQ3	intact:EBI-1257113	intact:EBI-3445062|uniprotkb:Q9P0X1|uniprotkb:Q2KQ75|uniprotkb:Q5JNZ7|ensembl:ENSP00000369465	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:txlng_human(display_long)|uniprotkb:TXLNG(gene name)|psi-mi:TXLNG(display_short)|uniprotkb:CXorf15(gene name synonym)|uniprotkb:ELRG(gene name synonym)|uniprotkb:LSR5(gene name synonym)|uniprotkb:Environmental lipopolysaccharide-responding gene protein(gene name synonym)|uniprotkb:Factor inhibiting ATF4-mediated transcription(gene name synonym)|uniprotkb:Lipopolysaccharide-specific response protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001162154.1|refseq:NP_060830.2|ensembl:ENSG00000086712(gene)|ensembl:ENST00000380122(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR026183	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0doUc9vE4XTNMsGyGAIHLzzx1W89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UQE7	intact:EBI-1257113	intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95239	intact:EBI-1257113	intact:EBI-1057516|uniprotkb:Q86TN3|uniprotkb:Q86XX7|uniprotkb:Q9NNY6|uniprotkb:Q9NY24|uniprotkb:Q9UMW3|uniprotkb:D3DVU4|uniprotkb:B2R7V5|ensembl:ENSP00000363524	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kif4a_human(display_long)|uniprotkb:KIF4A(gene name)|psi-mi:KIF4A(display_short)|uniprotkb:KIF4(gene name synonym)|uniprotkb:Chromokinesin-A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036442.3|ensembl:ENSG00000090889(gene)|ensembl:ENST00000374403(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|interpro:IPR027417|interpro:IPR036961|mint:O95239|rcsb pdb:6OYL|reactome:R-HSA-2132295|reactome:R-HSA-437239|reactome:R-HSA-6811434|reactome:R-HSA-983189|go:"GO:0006996"(organelle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030496"(midbody)|go:"GO:0046872"(metal ion binding)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Dn015O/tY/LZAnI5oVnvTVQH3Zk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96MG7	intact:EBI-1257113	intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9ULW0	intact:EBI-1257113	intact:EBI-1037322|uniprotkb:Q9H1R4|uniprotkb:Q9NRA3|uniprotkb:Q9UFN9|uniprotkb:Q9UL00|uniprotkb:Q9Y2M1|intact:EBI-2554635|uniprotkb:Q96RR5|intact:EBI-28976825|ensembl:ENSP00000300403	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tpx2_human(display_long)|uniprotkb:TPX2(gene name)|psi-mi:TPX2(display_short)|uniprotkb:C20orf1(gene name synonym)|uniprotkb:C20orf2(gene name synonym)|uniprotkb:DIL2(gene name synonym)|uniprotkb:HCA519(gene name synonym)|uniprotkb:Restricted expression proliferation-associated protein 100(gene name synonym)|uniprotkb:Differentially expressed in cancerous and non-cancerous lung cells 2(gene name synonym)|uniprotkb:Protein fls353(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 519(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 90(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-36727N|refseq:NP_036244.2|ensembl:ENSP00000300403|ensembl:ENST00000340513|ensembl:ENSP00000341145|refseq:XP_011526999.1|refseq:XP_011527001.1|dip:DIP-46212N|ensembl:ENSG00000088325(gene)|ensembl:ENST00000300403(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006915"(apoptotic process)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043203"(axon hillock)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR009675(Targeting for Xklp2)|interpro:IPR015128(Aurora-A binding)|interpro:IPR027329|interpro:IPR027330|mint:Q9ULW0|rcsb pdb:1OL5|rcsb pdb:3E5A|rcsb pdb:3HA6|rcsb pdb:4C3P|rcsb pdb:5LXM|rcsb pdb:6BJC|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|reactome:R-HSA-6804756|reactome:R-HSA-8854518	-	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dQbYLMi2nP9JPEbdDMk4R4arVxw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTI5	intact:EBI-1257113	intact:EBI-1175604|uniprotkb:Q5R3S3|uniprotkb:Q5W0K8|uniprotkb:Q6NSC3|uniprotkb:Q8IXT6|uniprotkb:Q9H5N8|uniprotkb:Q9Y2I5|uniprotkb:Q9Y451|intact:EBI-2554539|ensembl:ENSP00000313851	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pds5b_human(display_long)|uniprotkb:Androgen-induced proliferation inhibitor(gene name synonym)|uniprotkb:Androgen-induced prostate proliferative shutoff-associated protein AS3(gene name synonym)|uniprotkb:PDS5B(gene name)|psi-mi:PDS5B(display_short)|uniprotkb:AS3(gene name synonym)|uniprotkb:KIAA0979(gene name synonym)|uniprotkb:APRIN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000083642(gene)|ensembl:ENST00000315596(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039776|mint:Q9NTI5|rcsb pdb:5HDT|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|refseq:NP_055847.1|refseq:XP_016875939.1|dip:DIP-35420N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MOHd5JOiq96RzbEkvMje913OAdQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15436	intact:EBI-1257113	intact:EBI-81088|uniprotkb:B2R5P4|uniprotkb:Q8NE16|ensembl:ENSP00000306881|uniprotkb:B3KXI2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc23a_human(display_long)|uniprotkb:SEC23A(gene name)|psi-mi:SEC23A(display_short)|uniprotkb:SEC23-related protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006355.2|ensembl:ENST00000307712(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|ensembl:ENSG00000100934(gene)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|mint:Q15436|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:2YRC|rcsb pdb:2YRD|rcsb pdb:3EFO|rcsb pdb:3EG9|rcsb pdb:3EGD|rcsb pdb:3EGX|rcsb pdb:5KYN|rcsb pdb:5KYU|rcsb pdb:5KYW|rcsb pdb:5KYX|rcsb pdb:5KYY|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|interpro:IPR036180|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-5694530|reactome:R-HSA-983170|reactome:R-HSA-1655829	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:u1FCes02jPb3CGRj1aDkzpbSiuI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14579	intact:EBI-1257113	intact:EBI-711301|uniprotkb:O76097|ensembl:ENSP00000262812|uniprotkb:Q9UGP6|uniprotkb:Q6IBB8|uniprotkb:A6NKA3|uniprotkb:A6NE29	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cope_human(display_long)|uniprotkb:COPE(gene name)|psi-mi:COPE(display_short)|uniprotkb:Epsilon-coat protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009194.2|ensembl:ENSG00000105669(gene)|ensembl:ENST00000262812(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0099612"(protein localization to axon)|interpro:IPR006822(Coatomer, epsilon subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:O14579|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_955474.1|refseq:NP_955476.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gjrR0x7iNHl/nEDtoZTjThB1dgs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y266	intact:EBI-1257113	intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95197	intact:EBI-1257113	intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96Q89	intact:EBI-1257113	intact:EBI-1055300|uniprotkb:O43277|uniprotkb:Q09471|uniprotkb:Q2KQ73|uniprotkb:Q32NE1|uniprotkb:Q561V3|uniprotkb:Q58EX8|uniprotkb:Q5T9M8|uniprotkb:Q5T9M9|uniprotkb:Q5T9N0|uniprotkb:Q5T9N1|uniprotkb:Q7KZ68|uniprotkb:Q7Z5E0|uniprotkb:Q7Z5E1|uniprotkb:Q7Z6M9|uniprotkb:Q86X82|uniprotkb:Q9H3R8|uniprotkb:Q9H6Q9|uniprotkb:Q9H755|uniprotkb:Q9NTC1|uniprotkb:Q9UFR5|uniprotkb:A8MXM7|ensembl:ENSP00000360793	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ki20b_human(display_long)|uniprotkb:MPHOSPH1(gene name synonym)|uniprotkb:M-phase phosphoprotein 1(gene name synonym)|uniprotkb:Kinesin-related motor interacting with PIN1(gene name synonym)|uniprotkb:Cancer/testis antigen 90(gene name synonym)|uniprotkb:KIF20B(gene name)|psi-mi:KIF20B(display_short)|uniprotkb:KRMP1(gene name synonym)|uniprotkb:Kinesin family member 20B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001271188.1|refseq:NP_057279.2|ensembl:ENSG00000138182(gene)|ensembl:ENST00000371728(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070938"(contractile ring)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR028828|reactome:R-HSA-983189|reactome:R-HSA-6811434|dip:DIP-103N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QOOmPez8aHnIrd5XFB0jrSWtwn89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15464	intact:EBI-1257113	intact:EBI-4402156|uniprotkb:B9EGM0|uniprotkb:D3DRQ5|uniprotkb:Q504U5|uniprotkb:Q5VUM8|ensembl:ENSP00000366936	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:shb_human(display_long)|uniprotkb:SHB(gene name)|psi-mi:SHB(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003019.2|ensembl:ENSG00000107338(gene)|ensembl:ENST00000377707(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR000980(SH2 motif)|interpro:IPR035040|interpro:IPR035045|interpro:IPR036860|mint:Q15464|reactome:R-HSA-4420097	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DD+KZlDzdHYok9if0pI0b4yKcf49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95292	intact:EBI-1257113	intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q69YQ0	intact:EBI-1257113	intact:EBI-351113|uniprotkb:O15081|intact:EBI-10965349|uniprotkb:B7Z758|uniprotkb:F5H1H6|ensembl:ENSP00000325785|ensembl:ENSP00000393363|ensembl:ENSP00000439633	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cytsa_human(display_long)|uniprotkb:SPECC1L(gene name)|psi-mi:SPECC1L(display_short)|uniprotkb:Renal carcinoma antigen NY-REN-22(gene name synonym)|uniprotkb:CYTSA(gene name synonym)|uniprotkb:KIAA0376(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056145.4|refseq:NP_001241661.2|dip:DIP-33173N|ensembl:ENSG00000100014(gene)|ensembl:ENST00000314328(transcript)|ensembl:ENST00000437398(transcript)|ensembl:ENST00000541492(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005921"(gap junction)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0051301"(cell division)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|interpro:IPR040166|mint:Q69YQ0	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iYg2RCRo/dMtmwyppU7ywkhkolI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P48444	intact:EBI-1257113	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UID3	intact:EBI-1257113	intact:EBI-2932923|ensembl:ENSP00000279281|uniprotkb:Q6PJV5|uniprotkb:Q7L8A6|uniprotkb:Q8WZ35|uniprotkb:Q96DF4|uniprotkb:Q96GR3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps51_human(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR014812(Vps51/Vps67)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UID3|rcsb pdb:4J2C|reactome:R-HSA-6811440|refseq:NP_037397.2|dip:DIP-60562N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96B36	intact:EBI-1257113	intact:EBI-720593|ensembl:ENSP00000341698|ensembl:ENSP00000375707|ensembl:ENSP00000375708|ensembl:ENSP00000375709|ensembl:ENSP00000375710|uniprotkb:J3KPM3|uniprotkb:Q96BI4|uniprotkb:Q96IK7|uniprotkb:Q96NG2|uniprotkb:Q9BWR5|uniprotkb:A8MTQ1|uniprotkb:B2RE93	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:akts1_human(display_long)|uniprotkb:40 kDa proline-rich AKT substrate(gene name synonym)|uniprotkb:AKT1S1(gene name)|psi-mi:AKT1S1(display_short)|uniprotkb:PRAS40(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000204673(gene)|ensembl:ENST00000344175(transcript)|ensembl:ENST00000391831(transcript)|ensembl:ENST00000391832(transcript)|ensembl:ENST00000391833(transcript)|ensembl:ENST00000391834(transcript)|refseq:NP_001092102.1|refseq:NP_001092103.1|refseq:NP_001265088.1|refseq:NP_001265089.1|refseq:NP_115751.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|interpro:IPR026682|mint:Q96B36|rcsb pdb:5WBL|rcsb pdb:5WBU|rcsb pdb:5WBY|go:"GO:0043523"(regulation of neuron apoptotic process)|rcsb pdb:6SB0|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-198323|reactome:R-HSA-3371571|reactome:R-HSA-5674400	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Capqfe8k0cG3E3nLJskNIEAkBfI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13257	intact:EBI-1257113	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35579	intact:EBI-1257113	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51610	intact:EBI-1257113	intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTJ3	intact:EBI-1257113	intact:EBI-356173|uniprotkb:A6NLT9|uniprotkb:O95752|uniprotkb:Q8NDL4|uniprotkb:Q9UNT9|uniprotkb:D3DNL8|ensembl:ENSP00000341382|ensembl:ENSP00000349961	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc4_human(display_long)|uniprotkb:SMC4(gene name)|psi-mi:SMC4(display_short)|uniprotkb:CAPC(gene name synonym)|uniprotkb:SMC4L1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001002800.1|refseq:NP_005487.3|refseq:XP_011510613.1|refseq:NP_001275682.1|ensembl:ENSG00000113810(gene)|ensembl:ENST00000344722(transcript)|ensembl:ENST00000357388(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q9NTJ3|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853|dip:DIP-32946N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+2lnTSgTXZwRawJ/ASBRa6EDgv09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y296	intact:EBI-1257113	intact:EBI-722888|uniprotkb:B4DME1|uniprotkb:A8K3A5|intact:EBI-28967645|ensembl:ENSP00000436005|ensembl:ENSP00000487467	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tppc4_human(display_long)|uniprotkb:Synbindin(gene name synonym)|uniprotkb:TRS23 homolog(gene name synonym)|uniprotkb:Hematopoietic stem/progenitor cell protein 172(gene name synonym)|uniprotkb:TRAPPC4(gene name)|psi-mi:TRAPPC4(display_short)|uniprotkb:SBDN(gene name synonym)|uniprotkb:CGI-104(orf name)|uniprotkb:HSPC172(orf name)|uniprotkb:PTD009(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000487467|ensembl:ENST00000629713|ensembl:ENSP00000486496|refseq:NP_057230.1|ensembl:ENST00000434101|ensembl:ENSP00000405033|ensembl:ENSP00000436005|refseq:NP_001305415.1|refseq:NP_001305417.1|refseq:NP_001305418.1|refseq:NP_001305419.1|refseq:NP_001305421.1|refseq:NP_001305423.1|dip:DIP-37871N|ensembl:ENSG00000196655(gene)|ensembl:ENSG00000280495(gene)|ensembl:ENST00000533632(transcript)|ensembl:ENST00000629243(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016358"(dendrite development)|go:"GO:0030008"(TRAPP complex)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR007233(Sybindin-like protein)|interpro:IPR011012(Longin-like)|rcsb pdb:2J3T|rcsb pdb:2JSN|rcsb pdb:2ZMV|reactome:R-HSA-204005|reactome:R-HSA-3000170|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9Dqiz8Vo+JYaAoNESIFFuhf2yc09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62136	intact:EBI-1257113	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHY1	intact:EBI-1257113	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y678	intact:EBI-1257113	intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5UIP0	intact:EBI-1257113	intact:EBI-711331|uniprotkb:A6NC27|uniprotkb:C9JBR1|uniprotkb:Q5H9R3|uniprotkb:Q5UIP2|uniprotkb:Q66YK6|uniprotkb:Q6PRU2|uniprotkb:Q8TE94|uniprotkb:Q99772|uniprotkb:Q9H830|uniprotkb:Q9H9B9|uniprotkb:Q9NVP5|uniprotkb:Q9Y4R4|ensembl:ENSP00000243326|ensembl:ENSP00000390181	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rif1_human(display_long)|uniprotkb:RIF1(gene name)|psi-mi:RIF1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566|mint:Q5UIP0|reactome:R-HSA-5693571|ensembl:ENSG00000080345(gene)|ensembl:ENST00000243326(transcript)|ensembl:ENST00000444746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_001171134.1|refseq:NP_001171135.1|refseq:NP_001171136.1|refseq:NP_060621.3|refseq:XP_005246722.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XM3dyJZ0U4P2OUvgW3LOX2MLRDs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61923	intact:EBI-1257113	intact:EBI-1049939|uniprotkb:Q549N6|uniprotkb:Q9Y3C3|uniprotkb:B4DDX8|uniprotkb:F8VS17|uniprotkb:F8VWL5|uniprotkb:B4DHZ0|ensembl:ENSP00000262061	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copz1_human(display_long)|uniprotkb:Zeta-1-coat protein(gene name synonym)|uniprotkb:COPZ1(gene name)|psi-mi:COPZ1(display_short)|uniprotkb:COPZ(gene name synonym)|uniprotkb:CGI-120(orf name)|uniprotkb:HSPC181(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057141.1|refseq:NP_001258663.1|refseq:NP_001258664.1|refseq:NP_001258665.1|ensembl:ENST00000262061(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR039652|rcsb pdb:2HF6|rcsb pdb:5MC7|reactome:R-HSA-6807878|reactome:R-HSA-6811434|ensembl:ENSG00000111481(gene)|dip:DIP-29873N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1/IgMqSz7ThLUzNhR4ARUq+Gr6I9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51572	intact:EBI-1257113	intact:EBI-77683|ensembl:ENSP00000343458|ensembl:ENSP00000494052|ensembl:ENSP00000499882|uniprotkb:Q13836|uniprotkb:Q96CF0|uniprotkb:D3DWV5|uniprotkb:B3KQ79	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bap31_human(display_long)|uniprotkb:BCAP31(gene name)|psi-mi:BCAP31(display_short)|uniprotkb:BAP31(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:6C6-AG tumor-associated antigen(gene name synonym)|uniprotkb:DXS1357E(gene name synonym)|uniprotkb:Protein CDM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001132913.1|refseq:NP_005736.3|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904154"(positive regulation of retrograde protein transport, ER to cytosol)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:P51572|rcsb pdb:4JZL|rcsb pdb:4JZP|reactome:R-HSA-111465|reactome:R-HSA-75153|reactome:R-HSA-8980692|reactome:R-HSA-983170|ensembl:ENSG00000185825(gene)|ensembl:ENST00000345046(transcript)|ensembl:ENST00000647529(transcript)|ensembl:ENST00000672675(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001243376.1|refseq:NP_001132929.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m0aN00PLZJDWA/K1vEbla1W9+S89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P84077	intact:EBI-1257113	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBV2	intact:EBI-1257113	intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4A6	intact:EBI-1257113	intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NFJ5	intact:EBI-1257113	intact:EBI-2561555|ensembl:ENSP00000014914|uniprotkb:O95357|uniprotkb:B3KV45	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rai3_human(display_long)|uniprotkb:GPRC5A(gene name)|psi-mi:GPRC5A(display_short)|uniprotkb:GPCR5A(gene name synonym)|uniprotkb:RAI3(gene name synonym)|uniprotkb:RAIG1(gene name synonym)|uniprotkb:G-protein coupled receptor family C group 5 member A(gene name synonym)|uniprotkb:Retinoic acid-induced gene 1 protein(gene name synonym)|uniprotkb:Phorbol ester induced gene 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000013588(gene)|ensembl:ENST00000014914(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR017978|refseq:NP_003970.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:34/gAVA1PebkQgzu1veBTClSGcE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35222	intact:EBI-1257113	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60716	intact:EBI-1257113	intact:EBI-701927|uniprotkb:A8K939|uniprotkb:Q6DHZ7|uniprotkb:O15088|uniprotkb:O60713|uniprotkb:O60714|uniprotkb:O60715|uniprotkb:O60935|uniprotkb:Q6RBX8|uniprotkb:Q9UP71|uniprotkb:Q9UP72|uniprotkb:Q9UP73|ensembl:ENSP00000382004	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ctnd1_human(display_long)|uniprotkb:p120 catenin(gene name synonym)|uniprotkb:Cadherin-associated Src substrate(gene name synonym)|uniprotkb:"p120(cas)"(gene name synonym)|uniprotkb:CTNND1(gene name)|psi-mi:CTNND1(display_short)|uniprotkb:KIAA0384(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001078927.1|refseq:NP_001078928.1|refseq:NP_001078929.1|refseq:NP_001078930.1|refseq:NP_001078931.1|refseq:NP_001078932.1|refseq:NP_001078933.1|refseq:NP_001078934.1|refseq:NP_001078935.1|refseq:NP_001078936.1|refseq:NP_001078937.1|refseq:NP_001078938.1|refseq:NP_001193812.1|refseq:NP_001193813.1|refseq:NP_001193814.1|refseq:NP_001193815.1|refseq:NP_001193816.1|refseq:NP_001193817.1|refseq:NP_001193818.1|refseq:NP_001193819.1|refseq:NP_001193820.1|refseq:NP_001322.1|dip:DIP-33850N|ensembl:ENSG00000198561(gene)|ensembl:ENST00000399050(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007420"(brain development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0043197"(dendritic spine)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028439|mint:O60716|rcsb pdb:3L6X|rcsb pdb:3L6Y|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-8876493	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HgMvbcDKedE291TIvIOqLFT3srw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P28482	intact:EBI-1257113	intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:odzhd70I/8uWedx0+gF38lhe60I9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P18031	intact:EBI-1257113	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16644	intact:EBI-1257113	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60610	intact:EBI-1257113	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49768	intact:EBI-1257113	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q93008	intact:EBI-1257113	intact:EBI-302524|intact:EBI-1058656|intact:EBI-28978998|ensembl:ENSP00000367558|uniprotkb:O75550|uniprotkb:Q8WWT3|uniprotkb:Q8WX12	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:usp9x_human(display_long)|uniprotkb:USP9X(gene name)|psi-mi:USP9X(display_short)|uniprotkb:DFFRX(gene name synonym)|uniprotkb:USP9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:FAM(gene name synonym)|uniprotkb:Fat facets in mammals(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000124486(gene)|ensembl:ENST00000378308(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007292"(female gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-2173795|reactome:R-HSA-5689880|reactome:R-HSA-8866652|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9033241|reactome:R-HSA-977225|go:"GO:0048675"(axon extension)|refseq:NP_001034679.2|refseq:NP_001034680.2|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR031226|interpro:IPR038765|mint:Q93008|rcsb pdb:5VBD|rcsb pdb:5WCH|ensembl:ENST00000324545|ensembl:ENSP00000316357|ensembl:ENSP00000367558|dip:DIP-27562N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f9AWz8rAV8rMTqcQ46VrYYLTHq89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BQ95	intact:EBI-1257113	intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P45985	intact:EBI-1257113	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62993	intact:EBI-1257113	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6Y7W6	intact:EBI-1257113	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P15374	intact:EBI-1257113	intact:EBI-954554|uniprotkb:Q5TBK8|uniprotkb:Q6IBE9|ensembl:ENSP00000366819|uniprotkb:B2R970	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:uchl3_human(display_long)|uniprotkb:Ubiquitin thioesterase L3(gene name synonym)|uniprotkb:UCHL3(gene name)|psi-mi:UCHL3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001257881.1|refseq:NP_005993.1|ensembl:ENSG00000118939(gene)|ensembl:ENST00000377595(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043687"(post-translational protein modification)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|rcsb pdb:1UCH|rcsb pdb:1XD3|rcsb pdb:6ISU|rcsb pdb:6QML|reactome:R-HSA-5689603|reactome:R-HSA-8866652|reactome:R-HSA-8951664|dip:DIP-29135N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cPnctBpxrgvBKBSaQmhCsyd2nRM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P53041	intact:EBI-1257113	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P08754	intact:EBI-1257113	intact:EBI-357563|uniprotkb:Q5TZX1|uniprotkb:P17539|ensembl:ENSP00000358867	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gnai3_human(display_long)|uniprotkb:GNAI3(gene name)|psi-mi:GNAI3(display_short)|uniprotkb:"G(i) alpha-3"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006487.1|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|ensembl:ENSG00000065135(gene)|ensembl:ENST00000369851(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:2IHB|rcsb pdb:2ODE|rcsb pdb:2V4Z|rcsb pdb:4G5O|rcsb pdb:4G5R|rcsb pdb:4G5S|rcsb pdb:7E9H|rcsb pdb:7KH0|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9009391|reactome:R-HSA-9660821	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:npLeIXVzrV8y0trCCII5rivIRYQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q49A26	intact:EBI-1257113	intact:EBI-2804292|ensembl:ENSP00000322716|uniprotkb:Q6P1Q2|uniprotkb:C9JJ40|uniprotkb:Q9BTI1|uniprotkb:Q9BXK2|uniprotkb:Q6V3W7|uniprotkb:C9JJ60|uniprotkb:B4DL47|uniprotkb:Q5U632	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:glyr1_human(display_long)|uniprotkb:HIBDL(gene name synonym)|uniprotkb:NP60(gene name synonym)|uniprotkb:3-hydroxyisobutyrate dehydrogenase-like protein(gene name synonym)|uniprotkb:Cytokine-like nuclear factor N-PAC(gene name synonym)|uniprotkb:Glyoxylate reductase 1 homolog(gene name synonym)|uniprotkb:Nuclear protein NP60(gene name synonym)|uniprotkb:Nuclear protein of 60 kDa(gene name synonym)|uniprotkb:GLYR1(gene name)|psi-mi:GLYR1(display_short)|uniprotkb:NDF(gene name synonym)|uniprotkb:Nucleosome-destabilizing factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000140632(gene)|ensembl:ENST00000321919(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR000313(PWWP)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR029154|interpro:IPR035501|interpro:IPR036291|mint:Q49A26|rcsb pdb:2UYY|rcsb pdb:4GUR|rcsb pdb:4GUS|rcsb pdb:4GUT|rcsb pdb:4GUU|rcsb pdb:4HSU|rcsb pdb:6R1U|rcsb pdb:6R25|refseq:XP_011521019.1|refseq:NP_001295025.1|refseq:NP_115958.2|refseq:NP_001311026.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QsJhkB7Klk8D2R03vqPZzbi3f9g9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27361	intact:EBI-1257113	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BZE9	intact:EBI-1257113	intact:EBI-1993677|uniprotkb:Q7Z6N7|uniprotkb:Q8WV59|uniprotkb:Q96LS5|uniprotkb:Q96M40|uniprotkb:A8K3K9|ensembl:ENSP00000302176	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aspc1_human(display_long)|uniprotkb:ASPSCR1(gene name)|psi-mi:ASPSCR1(display_short)|uniprotkb:ASPL(gene name synonym)|uniprotkb:RCC17(gene name synonym)|uniprotkb:TUG(gene name synonym)|uniprotkb:Alveolar soft part sarcoma chromosomal region candidate gene 1 protein(gene name synonym)|uniprotkb:Alveolar soft part sarcoma locus(gene name synonym)|uniprotkb:Renal papillary cell carcinoma protein 17(gene name synonym)|uniprotkb:UBXD9(gene name synonym)|uniprotkb:UBXN9(gene name synonym)|uniprotkb:UBX domain-containing protein 9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_076988.1|refseq:NP_001317457.1|refseq:NP_001238817.1|ensembl:ENSG00000169696(gene)|ensembl:ENST00000306739(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001012(UBX)|interpro:IPR021569|interpro:IPR029071|rcsb pdb:5IFS|rcsb pdb:5IFW|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BH0vEBbHOcfdyDQmy4THVSiBdtg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14672	intact:EBI-1257113	intact:EBI-1536151|uniprotkb:Q10742|uniprotkb:Q92650|uniprotkb:B4DU28|ensembl:ENSP00000260408	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ada10_human(display_long)|uniprotkb:ADAM10(gene name)|psi-mi:ADAM10(display_short)|uniprotkb:KUZ(gene name synonym)|uniprotkb:MADM(gene name synonym)|uniprotkb:Mammalian disintegrin-metalloprotease(gene name synonym)|uniprotkb:Kuzbanian protein homolog(gene name synonym)|uniprotkb:CDw156(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001101.1|dip:DIP-39889N|ensembl:ENSG00000137845(gene)|ensembl:ENST00000260408(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042117"(monocyte activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0051089"(constitutive protein ectodomain proteolysis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090102"(cochlea development)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1901342"(regulation of vasculature development)|go:"GO:1901998"(toxin transport)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR027053|interpro:IPR034025|interpro:IPR036436|mint:O14672|rcsb pdb:1M1I|rcsb pdb:6BDZ|rcsb pdb:6BE6|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-177929|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-977225	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oaWIe6XWClYEFZKUARbeLsWRsu49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBI1	intact:EBI-1257113	intact:EBI-714979|uniprotkb:Q5T8Y9|uniprotkb:D3DRU7|ensembl:ENSP00000366032	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:comd3_human(display_long)|uniprotkb:Protein Bup(gene name synonym)|uniprotkb:Protein PIL(gene name synonym)|uniprotkb:COMMD3(gene name)|psi-mi:COMMD3(display_short)|uniprotkb:BUP(gene name synonym)|uniprotkb:C10orf8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036203.1|ensembl:ENSG00000148444(gene)|ensembl:ENST00000376836(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0006814"(sodium ion transport)|interpro:IPR017920|interpro:IPR037355|reactome:R-HSA-6798695|reactome:R-HSA-8951664|go:"GO:1904813"(ficolin-1-rich granule lumen)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:t9j9U/cA+1XMiybcmixYycqq/nE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6PML9	intact:EBI-1257113	intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P04899	intact:EBI-1257113	intact:EBI-353997|uniprotkb:Q8IZ71|intact:EBI-2563889|uniprotkb:B4DYA0|intact:EBI-4404691|uniprotkb:Q6B6N3|uniprotkb:B3KTZ0|uniprotkb:B4E2X5|ensembl:ENSP00000312999	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gnai2_human(display_long)|uniprotkb:GNAI2(gene name)|psi-mi:GNAI2(display_short)|uniprotkb:GNAI2B(gene name synonym)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002061.1|refseq:NP_001269546.1|refseq:NP_001269549.1|refseq:NP_001269547.1|refseq:NP_001269548.1|refseq:NP_001159897.1|dip:DIP-602N|ensembl:ENSG00000114353(gene)|ensembl:ENST00000313601(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:0030425"(dendrite)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:6D9H|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-400042|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-422356|reactome:R-HSA-9009391|reactome:R-HSA-9660821|mint:P04899	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Mi3PAXudkdPb375bOi7luNAmUaU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14764	intact:EBI-1257113	intact:EBI-2816254|uniprotkb:Q9BPW6|uniprotkb:Q9BQT1|uniprotkb:Q96BG4|uniprotkb:Q9UBD1|intact:EBI-28971732|ensembl:ENSP00000349977|ensembl:ENSP00000378760	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mvp_human(display_long)|uniprotkb:MVP(gene name)|psi-mi:MVP(display_short)|uniprotkb:LRP(gene name synonym)|uniprotkb:Lung resistance-related protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000349977|ensembl:ENSP00000378760|refseq:NP_001280133.1|refseq:NP_001280134.1|refseq:NP_005106.2|refseq:NP_059447.2|ensembl:ENSG00000013364(gene)|ensembl:ENST00000357402(transcript)|ensembl:ENST00000395353(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|mint:Q14764|rcsb pdb:1Y7X|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/Hc6TeTzO5QSpZ8AUXiI2ox4eg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42224	intact:EBI-1257113	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q05397	intact:EBI-1257113	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P29992	intact:EBI-1257113	intact:EBI-1171154|uniprotkb:O15109|uniprotkb:Q14350|uniprotkb:Q6IB00|ensembl:ENSP00000078429	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gna11_human(display_long)|uniprotkb:GNA11(gene name)|psi-mi:GNA11(display_short)|uniprotkb:GA11(gene name synonym)|uniprotkb:"Guanine nucleotide-binding protein G(y) subunit alpha"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002058.2|ensembl:ENSG00000088256(gene)|ensembl:ENST00000078429(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045634"(regulation of melanocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071467"(cellular response to pH)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P29992|rcsb pdb:6OIJ|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tb/5F5leSFWxmZySr0PzfPIbLAQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6PHR2	intact:EBI-1257113	intact:EBI-1383475|uniprotkb:B2RXK3|uniprotkb:Q9NPN5|uniprotkb:Q9UFS4|uniprotkb:B4DRQ7|uniprotkb:D3DW68|uniprotkb:B4DFT0|ensembl:ENSP00000400312	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ulk3_human(display_long)|uniprotkb:ULK3(gene name)|psi-mi:ULK3(display_short)|uniprotkb:Unc-51-like kinase 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_005254346.1|refseq:NP_001271293.2|refseq:NP_001092906.3|refseq:NP_001271294.1|ensembl:ENSG00000140474(gene)|ensembl:ENST00000440863(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0072537"(fibroblast activation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097542"(ciliary tip)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905037"(autophagosome organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR007330(MIT)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036181|rcsb pdb:4WZX|rcsb pdb:6FDY|rcsb pdb:6FDZ|reactome:R-HSA-5632684|go:"GO:0045879"(negative regulation of smoothened signaling pathway)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:B/PdKBoRF2UdrRIBktKbIrjFghE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:B4E074	intact:EBI-1257113	intact:EBI-4402091	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:b4e074_human(display_long)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR012972(NLE)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|go:"GO:0005730"(nucleolus)|go:"GO:0007219"(Notch signaling pathway)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lkSTdMJyAqocyDTZt3CMxb0cUkA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49841	intact:EBI-1257113	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63244	intact:EBI-1257113	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P43405	intact:EBI-1257113	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P67775	intact:EBI-1257113	intact:EBI-712311|ensembl:ENSP00000418447|uniprotkb:P05323|uniprotkb:P13197	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pp2aa_human(display_long)|uniprotkb:PPP2CA(gene name)|psi-mi:PPP2CA(display_short)|uniprotkb:Replication protein C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113575(gene)|ensembl:ENST00000481195(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904526"(regulation of microtubule binding)|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P67775|rcsb pdb:2IAE|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3FGA|rcsb pdb:3K7W|rcsb pdb:3P71|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4IYP|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2995383|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|rcsb pdb:3K7V|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_002706.1|dip:DIP-29395N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Zynydo3YUFioN2iUl6oR0nVJ4YY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51452	intact:EBI-1257113	intact:EBI-1049755|uniprotkb:Q5U0J1|uniprotkb:D3DX45|ensembl:ENSP00000226004|uniprotkb:Q8IYJ9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dus3_human(display_long)|uniprotkb:Dual specificity protein phosphatase VHR(gene name synonym)|uniprotkb:DUSP3(gene name)|psi-mi:DUSP3(display_short)|uniprotkb:VHR(gene name synonym)|uniprotkb:Vaccinia H1-related phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004081.1|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033549"(MAP kinase phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020405|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1J4X|rcsb pdb:1VHR|rcsb pdb:3F81|reactome:R-HSA-202670|ensembl:ENSG00000108861(gene)|ensembl:ENST00000226004(transcript)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1kqI9JZrOBsMIH4M2AoWBOmQPko9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q53EL6	intact:EBI-1257113	intact:EBI-935824|uniprotkb:O15501|uniprotkb:Q5VZS6|uniprotkb:Q6PJI5|uniprotkb:Q8TAR5|uniprotkb:Q99834|intact:EBI-2514227|uniprotkb:B2RCV4|uniprotkb:B5ME91|ensembl:ENSP00000280154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pdcd4_human(display_long)|uniprotkb:PDCD4(gene name)|psi-mi:PDCD4(display_short)|uniprotkb:H731(gene name synonym)|uniprotkb:Nuclear antigen H731-like(gene name synonym)|uniprotkb:Neoplastic transformation inhibitor protein(gene name synonym)|uniprotkb:Protein 197/15a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055271.2|refseq:NP_663314.1|dip:DIP-29756N|ensembl:ENSG00000150593(gene)|ensembl:ENST00000280154(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007569"(cell aging)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039778|rcsb pdb:2GGF|rcsb pdb:2KZT|rcsb pdb:2RG8|rcsb pdb:2ZU6|rcsb pdb:3EIJ|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kkqDk2CCFvHpSCKNDzV4wqSm1HE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75473	intact:EBI-1257113	intact:EBI-4402067|uniprotkb:D8MCT0|uniprotkb:Q4VAM0|uniprotkb:Q4VAM2|uniprotkb:Q9UP75|ensembl:ENSP00000266674	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lgr5_human(display_long)|uniprotkb:LGR5(gene name)|psi-mi:LGR5(display_short)|uniprotkb:GPR49(gene name synonym)|uniprotkb:GPR67(gene name synonym)|uniprotkb:G-protein coupled receptor 49(gene name synonym)|uniprotkb:G-protein coupled receptor 67(gene name synonym)|uniprotkb:G-protein coupled receptor HG38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001264156.1|refseq:NP_003658.1|refseq:NP_001264155.1|ensembl:ENSG00000139292(gene)|ensembl:ENST00000266674(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009994"(oocyte differentiation)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR032675|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4KNG|rcsb pdb:4UFR|rcsb pdb:4UFS|reactome:R-HSA-4641263	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vr9w3DGBW36fsvM+M0/jfktA3/09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62877	intact:EBI-1257113	intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13485	intact:EBI-1257113	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HB71	intact:EBI-1257113	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16539	intact:EBI-1257113	intact:EBI-73946|uniprotkb:A8K6P4|uniprotkb:B0LPH0|uniprotkb:A6ZJ92|uniprotkb:O60776|uniprotkb:Q13083|uniprotkb:Q14084|uniprotkb:Q8TDX0|uniprotkb:B5TY32|ensembl:ENSP00000229794	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk14_human(display_long)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001306.1|refseq:NP_620581.1|refseq:NP_620582.1|refseq:NP_620583.1|dip:DIP-30987N|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:Q16539|rcsb pdb:1A9U|rcsb pdb:1BL6|rcsb pdb:1BL7|rcsb pdb:1BMK|rcsb pdb:1DI9|rcsb pdb:1IAN|rcsb pdb:1KV1|rcsb pdb:1KV2|rcsb pdb:1M7Q|rcsb pdb:1OUK|rcsb pdb:1OUY|rcsb pdb:1OVE|rcsb pdb:1OZ1|rcsb pdb:1R39|rcsb pdb:1R3C|rcsb pdb:1W7H|rcsb pdb:1W82|rcsb pdb:1W83|rcsb pdb:1W84|rcsb pdb:1WBN|rcsb pdb:1WBO|rcsb pdb:1WBS|rcsb pdb:1WBT|rcsb pdb:1WBV|rcsb pdb:1WBW|rcsb pdb:1WFC|rcsb pdb:1YQJ|rcsb pdb:1ZYJ|rcsb pdb:1ZZ2|rcsb pdb:1ZZL|rcsb pdb:2BAJ|rcsb pdb:2BAK|rcsb pdb:2BAL|rcsb pdb:2BAQ|rcsb pdb:2FSL|rcsb pdb:2FSM|rcsb pdb:2FSO|rcsb pdb:2FST|rcsb pdb:2GFS|rcsb pdb:2I0H|rcsb pdb:2LGC|rcsb pdb:2NPQ|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2QD9|rcsb pdb:2RG5|rcsb pdb:2RG6|rcsb pdb:2Y8O|rcsb pdb:2YIS|rcsb pdb:2YIW|rcsb pdb:2YIX|rcsb pdb:2ZAZ|rcsb pdb:2ZB0|rcsb pdb:2ZB1|rcsb pdb:3BV2|rcsb pdb:3BV3|rcsb pdb:3BX5|rcsb pdb:3C5U|rcsb pdb:3CTQ|rcsb pdb:3D7Z|rcsb pdb:3D83|rcsb pdb:3DS6|rcsb pdb:3DT1|rcsb pdb:3E92|rcsb pdb:3E93|rcsb pdb:3FC1|rcsb pdb:3FI4|rcsb pdb:3FKL|rcsb pdb:3FKN|rcsb pdb:3FKO|rcsb pdb:3FL4|rcsb pdb:3FLN|rcsb pdb:3FLQ|rcsb pdb:3FLS|rcsb pdb:3FLW|rcsb pdb:3FLY|rcsb pdb:3FLZ|rcsb pdb:3FMH|rcsb pdb:3FMJ|rcsb pdb:3FMK|rcsb pdb:3FML|rcsb pdb:3FMM|rcsb pdb:3FMN|rcsb pdb:3FSF|rcsb pdb:3FSK|rcsb pdb:3GC7|rcsb pdb:3GCP|rcsb pdb:3GCQ|rcsb pdb:3GCS|rcsb pdb:3GCU|rcsb pdb:3GCV|rcsb pdb:3GFE|rcsb pdb:3GI3|rcsb pdb:3HA8|rcsb pdb:3HEC|rcsb pdb:3HEG|rcsb pdb:3HL7|rcsb pdb:3HLL|rcsb pdb:3HP2|rcsb pdb:3HP5|rcsb pdb:3HRB|rcsb pdb:3HUB|rcsb pdb:3HUC|rcsb pdb:3HV3|rcsb pdb:3HV4|rcsb pdb:3HV5|rcsb pdb:3HV6|rcsb pdb:3HV7|rcsb pdb:3HVC|rcsb pdb:3IPH|rcsb pdb:3ITZ|rcsb pdb:3IW5|rcsb pdb:3IW6|rcsb pdb:3IW7|rcsb pdb:3IW8|rcsb pdb:3K3I|rcsb pdb:3K3J|rcsb pdb:3KF7|rcsb pdb:3KQ7|rcsb pdb:3L8S|rcsb pdb:3L8X|rcsb pdb:3LFA|rcsb pdb:3LFB|rcsb pdb:3LFC|rcsb pdb:3LFD|rcsb pdb:3LFE|rcsb pdb:3LFF|rcsb pdb:3LHJ|rcsb pdb:3MGY|rcsb pdb:3MH0|rcsb pdb:3MH1|rcsb pdb:3MH2|rcsb pdb:3MH3|rcsb pdb:3MPA|rcsb pdb:3MPT|rcsb pdb:3MVL|rcsb pdb:3MVM|rcsb pdb:3MW1|rcsb pdb:3NEW|rcsb pdb:3NNU|rcsb pdb:3NNV|rcsb pdb:3NNW|rcsb pdb:3NNX|rcsb pdb:3NWW|rcsb pdb:3O8P|rcsb pdb:3O8T|rcsb pdb:3O8U|rcsb pdb:3OBG|rcsb pdb:3OBJ|rcsb pdb:3OC1|rcsb pdb:3OCG|rcsb pdb:3OD6|rcsb pdb:3ODY|rcsb pdb:3ODZ|rcsb pdb:3OEF|rcsb pdb:3PG3|rcsb pdb:3QUD|rcsb pdb:3QUE|rcsb pdb:3RIN|rcsb pdb:3ROC|rcsb pdb:3S3I|rcsb pdb:3S4Q|rcsb pdb:3U8W|rcsb pdb:3UVP|rcsb pdb:3UVQ|rcsb pdb:3UVR|rcsb pdb:3ZS5|rcsb pdb:3ZSG|rcsb pdb:3ZSH|rcsb pdb:3ZSI|rcsb pdb:3ZYA|rcsb pdb:4A9Y|rcsb pdb:4AA0|rcsb pdb:4AA4|rcsb pdb:4AA5|rcsb pdb:4AAC|rcsb pdb:4DLI|rcsb pdb:4DLJ|rcsb pdb:4E5A|rcsb pdb:4E5B|rcsb pdb:4E6A|rcsb pdb:4E6C|rcsb pdb:4E8A|rcsb pdb:4EH2|rcsb pdb:4EH3|rcsb pdb:4EH4|rcsb pdb:4EH5|rcsb pdb:4EH6|rcsb pdb:4EH7|rcsb pdb:4EH8|rcsb pdb:4EH9|rcsb pdb:4EHV|rcsb pdb:4EWQ|rcsb pdb:4F9W|rcsb pdb:4F9Y|rcsb pdb:4FA2|rcsb pdb:4GEO|rcsb pdb:4KIN|rcsb pdb:4KIP|rcsb pdb:4KIQ|rcsb pdb:4L8M|rcsb pdb:4R3C|rcsb pdb:4ZTH|rcsb pdb:5ETA|rcsb pdb:5ETC|rcsb pdb:5ETF|rcsb pdb:5ETI|rcsb pdb:5ML5|rcsb pdb:5MTX|rcsb pdb:5MTY|rcsb pdb:5MZ3|rcsb pdb:5N63|rcsb pdb:5N64|rcsb pdb:5N65|rcsb pdb:5N66|rcsb pdb:5N67|rcsb pdb:5N68|rcsb pdb:5O8U|rcsb pdb:5O8V|rcsb pdb:5OMG|rcsb pdb:5OMH|rcsb pdb:5TBE|rcsb pdb:5TCO|rcsb pdb:5WJJ|rcsb pdb:5XYX|rcsb pdb:5XYY|rcsb pdb:6ANL|rcsb pdb:6HWT|rcsb pdb:6HWU|rcsb pdb:6HWV|rcsb pdb:6M95|rcsb pdb:6M9L|rcsb pdb:6OHD|rcsb pdb:6QDZ|rcsb pdb:6QE1|rcsb pdb:6QYX|rcsb pdb:6RFO|rcsb pdb:6SFI|rcsb pdb:6SFJ|rcsb pdb:6SFK|rcsb pdb:6SFO|rcsb pdb:6TCA|rcsb pdb:6ZQS|rcsb pdb:6ZWP|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-198753|reactome:R-HSA-2151209|reactome:R-HSA-2559580|reactome:R-HSA-376172|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-4420097|reactome:R-HSA-450302|reactome:R-HSA-450341|reactome:R-HSA-450604|reactome:R-HSA-525793|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-9662834	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P45983	intact:EBI-1257113	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UPT6	intact:EBI-1257113	intact:EBI-717887|uniprotkb:A2A2B3|uniprotkb:Q96RY4|uniprotkb:Q9H4I4|uniprotkb:Q9H7P1|uniprotkb:Q9NUG0|uniprotkb:A7E2B3|ensembl:ENSP00000250894	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:jip3_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 3(gene name synonym)|uniprotkb:JIP3(gene name synonym)|uniprotkb:KIAA1066(gene name synonym)|uniprotkb:MAPK8IP3(gene name)|psi-mi:MAPK8IP3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035529.1|refseq:NP_055948.2|refseq:NP_001305781.1|ensembl:ENSG00000138834(gene)|ensembl:ENST00000250894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031103"(axon regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0044297"(cell body)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061564"(axon development)|go:"GO:0099641"(anterograde axonal protein transport)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR036322|interpro:IPR039911|mint:Q9UPT6|rcsb pdb:4PXJ|go:"GO:1904115"(axon cytoplasm)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PIL9w/kseAImo5TJWUxoTzlUjMg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TE67-3	intact:EBI-1257113	intact:EBI-4402059|ensembl:ENSP00000358820	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q8te67-3(display_long)|uniprotkb:A(isoform synonym)|uniprotkb:EPS8L3(gene name)|psi-mi:EPS8L3(display_short)|uniprotkb:EPS8R3(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000198758(gene)|ensembl:ENST00000369805(transcript)|intact:EBI-2481829(isoform-parent)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:b8E1LdK0mQzb+NU/WZ1D2rY+Lsw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P19784	intact:EBI-1257113	intact:EBI-347451|ensembl:ENSP00000262506	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P48729	intact:EBI-1257113	intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15796	intact:EBI-1257113	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y376	intact:EBI-1257113	intact:EBI-306905|ensembl:ENSP00000258418|ensembl:ENSP00000386238|ensembl:ENSP00000386642|uniprotkb:A8K8L7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cab39_human(display_long)|uniprotkb:CAB39(gene name)|psi-mi:CAB39(display_short)|uniprotkb:CGI-66(orf name)|uniprotkb:MO25alpha(gene name synonym)|uniprotkb:MO25(gene name synonym)|uniprotkb:Protein Mo25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013878(Mo25-like)|go:"GO:0014823"(response to activity)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:1UPK|ensembl:ENSG00000135932(gene)|ensembl:ENST00000258418(transcript)|ensembl:ENST00000409788(transcript)|ensembl:ENST00000410084(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:2WTK|rcsb pdb:3GNI|rcsb pdb:4FZA|rcsb pdb:4FZD|rcsb pdb:4FZF|rcsb pdb:4NZW|rcsb pdb:4O27|reactome:R-HSA-380972|reactome:R-HSA-6798695|rcsb pdb:1UPL|refseq:NP_001124321.1|refseq:NP_001124322.1|refseq:NP_057373.1|dip:DIP-31316N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lexzsGjO9gx4s7ANiX7FrBpg5wc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96P48	intact:EBI-1257113	intact:EBI-710003|uniprotkb:O94879|uniprotkb:Q4LDD5|uniprotkb:Q59FI7|uniprotkb:Q6PHS3|uniprotkb:Q8WU51|uniprotkb:Q96HP6|uniprotkb:A3KLL7|uniprotkb:Q96L71|uniprotkb:B2RTS2|intact:EBI-28975539|ensembl:ENSP00000377233	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arap1_human(display_long)|uniprotkb:ARAP1(gene name)|psi-mi:ARAP1(display_short)|uniprotkb:CENTD2(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)|uniprotkb:KIAA0782(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035207.1|refseq:NP_001128662.1|refseq:NP_056057.2|ensembl:ENSP00000403127|ensembl:ENST00000334211|ensembl:ENSP00000335506|ensembl:ENST00000359373|ensembl:ENSP00000352332|ensembl:ENST00000393605|ensembl:ENSP00000377230|ensembl:ENSP00000377233|ensembl:ENST00000429686|ensembl:ENSG00000186635(gene)|ensembl:ENST00000393609(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030037"(actin filament reorganization involved in cell cycle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:4X1V|reactome:R-HSA-8849469|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AI7JgE3FapPBfnzcwT+AtENUXbg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q4V328	intact:EBI-1257113	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y4A5	intact:EBI-1257113	intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42680	intact:EBI-1257113	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P57105	intact:EBI-1257113	intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6UB99	intact:EBI-1257113	intact:EBI-2808987|intact:EBI-28972094|ensembl:ENSP00000301030|ensembl:ENSP00000367581|ensembl:ENSP00000495226|uniprotkb:Q6QMF8|uniprotkb:Q6NTG1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anr11_human(display_long)|uniprotkb:ANKRD11(gene name)|psi-mi:ANKRD11(display_short)|uniprotkb:ANCO1(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000301030|ensembl:ENSP00000367581|ensembl:ENSP00000495226|ensembl:ENSG00000167522(gene)|ensembl:ENST00000301030(transcript)|ensembl:ENST00000378330(transcript)|ensembl:ENST00000642600(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0060325"(face morphogenesis)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR042636|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_037407.4|refseq:XP_011521353.1|refseq:XP_011521355.1|refseq:XP_016878671.1|refseq:XP_016878672.1|refseq:XP_016878673.1|refseq:XP_016878674.1|refseq:XP_016878675.1|refseq:XP_016878676.1|refseq:NP_001243111.1|refseq:NP_001243112.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Pf1MnOge8bLsMtwuzGAmCsuXFcA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00401	intact:EBI-1257113	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75955	intact:EBI-1257113	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q05655	intact:EBI-1257113	intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BR/lNGg6f55rGP91akTf8BLkX449606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75427	intact:EBI-1257113	intact:EBI-718707|uniprotkb:Q8WV85|uniprotkb:Q96ID0|uniprotkb:A4D2D5|ensembl:ENSP00000309689	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lrch4_human(display_long)|uniprotkb:Leucine-rich repeat neuronal protein 4(gene name synonym)|uniprotkb:LRCH4(gene name)|psi-mi:LRCH4(display_short)|uniprotkb:LRN(gene name synonym)|uniprotkb:LRRN4(gene name synonym)|uniprotkb:LRRN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002310.2|refseq:NP_001276863.1|ensembl:ENSG00000077454(gene)|ensembl:ENST00000310300(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0016605"(PML body)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oE4ILE6y/yYV10+MFT0PRwUXotg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15079	intact:EBI-1257113	intact:EBI-4401902|uniprotkb:Q8IYI3|ensembl:ENSP00000371297	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snph_human(display_long)|uniprotkb:SNPH(gene name)|psi-mi:SNPH(display_short)|uniprotkb:KIAA0374(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055538.2|refseq:NP_001305163.1|ensembl:ENSG00000101298(gene)|ensembl:ENST00000381873(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|interpro:IPR026196|interpro:IPR028197	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:r/15+9zzQbNGj3lg/Coji6sQ0v09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00750	intact:EBI-1257113	intact:EBI-641107|uniprotkb:O95666|uniprotkb:Q5SW99|intact:EBI-28974013|ensembl:ENSP00000356155|ensembl:ENSP00000507222	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p3c2b_human(display_long)|uniprotkb:Phosphoinositide 3-kinase-C2-beta(gene name synonym)|uniprotkb:C2-PI3K(gene name synonym)|uniprotkb:PIK3C2B(gene name)|psi-mi:PIK3C2B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000356155|ensembl:ENSP00000507222|refseq:XP_016856962.1|refseq:XP_016856963.1|refseq:NP_002637.3|ensembl:ENSG00000133056(gene)|ensembl:ENST00000367187(transcript)|ensembl:ENST00000684373(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR001683(Phox-like)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036871|interpro:IPR036940|interpro:IPR042134|interpro:IPR042236|mint:O00750|reactome:R-HSA-1660499|refseq:XP_011507932.1|refseq:XP_011507933.1|refseq:XP_005245314.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S8qMIq3xGq6ckSQ4mBDGb98wTGs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86Y82	intact:EBI-1257113	intact:EBI-2691717|uniprotkb:B1AJQ7|uniprotkb:O95564|ensembl:ENSP00000363054	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx12_human(display_long)|uniprotkb:STX12(gene name)|psi-mi:STX12(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_803173.1|ensembl:ENSG00000117758(gene)|ensembl:ENST00000373943(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:Q86Y82|rcsb pdb:2DNX|dip:DIP-44225N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kSTOaE08HK8SpI19dBZRZbOVCGw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60831	intact:EBI-1257113	intact:EBI-2506064|ensembl:ENSP00000451962|uniprotkb:B2RD20	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:praf2_human(display_long)|uniprotkb:PRAF2(gene name)|psi-mi:PRAF2(display_short)|uniprotkb:JM4(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000243279(gene)|ensembl:ENST00000553851(transcript)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:O60831|refseq:NP_009144.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZCku1zr9TwPArrSO0aaKZlDsEyU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95352	intact:EBI-1257113	intact:EBI-987834|uniprotkb:Q7L8L0|uniprotkb:Q9BWP2|uniprotkb:Q9UFH4|ensembl:ENSP00000346437|uniprotkb:B4E170|uniprotkb:E9PB95	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:atg7_human(display_long)|uniprotkb:ATG12-activating enzyme E1 ATG7(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1-like protein(gene name synonym)|uniprotkb:ATG7(gene name)|psi-mi:ATG7(display_short)|uniprotkb:APG7L(gene name synonym)|uniprotkb:Autophagy-related protein 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000197548(gene)|ensembl:ENST00000354449(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019778"(Atg12 activating enzyme activity)|go:"GO:0019779"(Atg8 activating enzyme activity)|go:"GO:0030424"(axon)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|interpro:IPR035985|interpro:IPR042522|go:"GO:0034774"(secretory granule lumen)|interpro:IPR042523|reactome:R-HSA-1632852|reactome:R-HSA-6798695|reactome:R-HSA-6802952|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:1902617"(response to fluoride)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR006285(E1-like protein-activating enzyme Gsa7p/Apg7p)|interpro:IPR032197|reactome:R-HSA-983168|refseq:XP_011531584.1|refseq:XP_011531588.1|refseq:NP_001129503.2|refseq:NP_001138384.1|refseq:NP_006386.1|refseq:XP_016861033.1|refseq:XP_016861034.1|refseq:XP_016861035.1|dip:DIP-29759N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:myjul9H3gvlZOK/NURXIkmjXspU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BR1	intact:EBI-1257113	intact:EBI-2801236|uniprotkb:A8K5W3|uniprotkb:Q9UKG5|uniprotkb:Q9P1Q7|uniprotkb:B3KQC2|ensembl:ENSP00000331816|ensembl:ENSP00000379842|ensembl:ENSP00000430256|ensembl:ENSP00000430463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgk3_human(display_long)|uniprotkb:SGKL(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 3(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase-like(gene name synonym)|uniprotkb:SGK3(gene name)|psi-mi:SGK3(display_short)|uniprotkb:CISK(gene name synonym)|uniprotkb:Cytokine-independent survival kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028750.1|refseq:NP_001191102.1|refseq:NP_037389.4|refseq:NP_733827.2|ensembl:ENSG00000104205(gene)|ensembl:ENST00000345714(transcript)|ensembl:ENST00000521198(transcript)|ensembl:ENST00000522398(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|ensembl:ENST00000396596(transcript)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001683(Phox-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR036871|interpro:IPR037709|interpro:IPR037900|mint:Q96BR1|rcsb pdb:6EDX|reactome:R-HSA-2672351|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H3ibqrLkptVGc+FDFmEiMSyKhts9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12873	intact:EBI-1257113	intact:EBI-523590|uniprotkb:Q9Y4I0|intact:EBI-28978117|ensembl:ENSP00000332628|uniprotkb:D3DTQ9|uniprotkb:E9PG89	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chd3_human(display_long)|uniprotkb:ATP-dependent helicase CHD3(gene name synonym)|uniprotkb:Mi-2 autoantigen 240 kDa protein(gene name synonym)|uniprotkb:Mi2-alpha(gene name synonym)|uniprotkb:Zinc finger helicase(gene name synonym)|uniprotkb:CHD3(gene name)|psi-mi:CHD3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR023780|interpro:IPR027417|interpro:IPR036910|interpro:IPR038718|mint:Q12873|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-4551638|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191|ensembl:ENSG00000170004(gene)|ensembl:ENST00000330494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007051"(spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016605"(PML body)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0043044"|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|go:"GO:0070615"|interpro:IPR019787|interpro:IPR023779|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|ensembl:ENSP00000332628|ensembl:ENST00000358181|ensembl:ENSP00000350907|ensembl:ENST00000380358|ensembl:ENSP00000369716|refseq:NP_001005271.2|refseq:NP_001005273.1|refseq:NP_005843.2|dip:DIP-32496N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UjefFUXiV28qhOP9BoIUansxl+k9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:B4DYU4	intact:EBI-1257113	intact:EBI-4401991	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:b4dyu4_human(display_long)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR016024(Armadillo-type fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR018936|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR037704|interpro:IPR036940|interpro:IPR029071|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|interpro:IPR035892|interpro:IPR042236	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tjCri2vTspdGlL9tOBDXhIm6LcU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HD26	intact:EBI-1257113	intact:EBI-349832|uniprotkb:A6NM30|uniprotkb:Q59FS4|uniprotkb:Q969U8|ensembl:ENSP00000357484	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gopc_human(display_long)|uniprotkb:CAL(gene name synonym)|uniprotkb:FIG(gene name synonym)|uniprotkb:GOPC(gene name)|psi-mi:GOPC(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym)|uniprotkb:CFTR-associated ligand(gene name synonym)|uniprotkb:Fused in glioblastoma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001017408.1|refseq:NP_065132.1|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045176"(apical protein localization)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR038879|mint:Q9HD26|rcsb pdb:2DC2|rcsb pdb:2LOB|rcsb pdb:4E34|rcsb pdb:4E35|rcsb pdb:4JOE|rcsb pdb:4JOF|rcsb pdb:4JOG|rcsb pdb:4JOH|rcsb pdb:4JOJ|rcsb pdb:4JOK|rcsb pdb:4JOP|rcsb pdb:4JOR|rcsb pdb:4K6Y|rcsb pdb:4K72|rcsb pdb:4K75|rcsb pdb:4K76|rcsb pdb:4K78|rcsb pdb:4NMO|rcsb pdb:4NMP|rcsb pdb:4NMQ|rcsb pdb:4NMR|rcsb pdb:4NMS|rcsb pdb:4NMT|go:"GO:0042802"(identical protein binding)|rcsb pdb:4NMV|rcsb pdb:4Q6H|rcsb pdb:4Q6S|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6OV7|rcsb pdb:6V84|rcsb pdb:6XNJ|reactome:R-HSA-5627083|reactome:R-HSA-9013406|ensembl:ENSG00000047932(gene)|ensembl:ENST00000368498(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032991"(protein-containing complex)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bXzu5wvJifZwB+Q52cgC4tZQl/k9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86VN1	intact:EBI-1257113	intact:EBI-4401822|uniprotkb:A8K125|uniprotkb:Q3ZCV7|uniprotkb:Q5H9S1|uniprotkb:Q5VXB6|uniprotkb:Q9H8Z5|uniprotkb:Q9Y3E3|ensembl:ENSP00000367299	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps36_human(display_long)|uniprotkb:VPS36(gene name)|psi-mi:VPS36(display_short)|uniprotkb:C13orf9(gene name synonym)|uniprotkb:EAP45(gene name synonym)|uniprotkb:ELL-associated protein of 45 kDa(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS36(gene name synonym)|uniprotkb:CGI-145(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057159.2|refseq:NP_001269098.1|dip:DIP-29249N|ensembl:ENSG00000136100(gene)|ensembl:ENST00000378060(transcript)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021648|interpro:IPR036388|interpro:IPR036390|interpro:IPR037855|interpro:IPR040608|rcsb pdb:2HTH|rcsb pdb:2ZME|rcsb pdb:3CUQ|reactome:R-HSA-917729|reactome:R-HSA-9610379	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LPnQXFgph4C6q8VJu1Fgrhn6clM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13190	intact:EBI-1257113	intact:EBI-714206|uniprotkb:Q5U0D4|uniprotkb:Q7Z3T6|uniprotkb:Q9BUG1|uniprotkb:B2R8T2|ensembl:ENSP00000294179|uniprotkb:F8W8Q9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx5_human(display_long)|uniprotkb:STX5(gene name)|psi-mi:STX5(display_short)|uniprotkb:STX5A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003155.2|ensembl:ENSG00000162236(gene)|ensembl:ENST00000294179(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031982"(vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0090166"(Golgi disassembly)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR021538|mint:Q13190|rcsb pdb:3EFO|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-8980692|reactome:R-HSA-9013106|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-9013408|reactome:R-HSA-9609523|refseq:NP_001231595.1|refseq:NP_001317223.1|dip:DIP-56987N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cR4cS695ZWQQ5Bkim9HqmCE0hCE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HAU0	intact:EBI-1257113	intact:EBI-945934|uniprotkb:Q86ST7|uniprotkb:A0JP03|uniprotkb:Q8N3K6|uniprotkb:Q96DY9|uniprotkb:Q9BVR4|uniprotkb:Q9C0H7|uniprotkb:Q9H924|uniprotkb:Q9NVK8|uniprotkb:B4DGS1|uniprotkb:F5H0I0|uniprotkb:E9PHQ3|uniprotkb:Q6NSF8|ensembl:ENSP00000299275	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkha5_human(display_long)|uniprotkb:PLEKHA5(gene name)|psi-mi:PLEKHA5(display_short)|uniprotkb:KIAA1686(gene name synonym)|uniprotkb:PEPP2(gene name synonym)|uniprotkb:Phosphoinositol 3-phosphate-binding protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000299275|ensembl:ENST00000424268|ensembl:ENSP00000400411|ensembl:ENST00000429027|ensembl:ENSP00000404296|ensembl:ENST00000538714|ensembl:ENSP00000439673|ensembl:ENST00000540972|ensembl:ENSP00000439396|refseq:NP_001137293.2|refseq:NP_061885.2|refseq:NP_001177789.2|refseq:NP_001243399.1|refseq:NP_001243716.1|refseq:XP_005253457.1|refseq:XP_016874992.1|refseq:XP_011519019.1|ensembl:ENSG00000052126(gene)|ensembl:ENST00000299275(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0061458"(reproductive system development)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR040392|mint:Q9HAU0|rcsb pdb:2DKP|reactome:R-HSA-1660499	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:22W2zdIwTLw4nNRh0dHasYDCLK49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5T0N5	intact:EBI-1257113	intact:EBI-714058|uniprotkb:J3QSS4|uniprotkb:Q5T0N6|uniprotkb:Q6B097|uniprotkb:Q6P653|uniprotkb:Q6R4Q4|uniprotkb:Q9NXG1|ensembl:ENSP00000271234	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fbp1l_human(display_long)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:C1orf39(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001020119.1|refseq:NP_001157945.1|refseq:NP_060207.2|interpro:IPR030116|interpro:IPR031160|interpro:IPR035493|interpro:IPR035494|interpro:IPR036028|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013409|ensembl:ENSG00000137942(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045296"(cadherin binding)|ensembl:ENST00000271234(transcript)|go:"GO:0051020"(GTPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060271"(cilium assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yGpTAKXe5mYtBFc89aMiYFMy9RU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43747	intact:EBI-1257113	intact:EBI-447609|uniprotkb:O75709|uniprotkb:O75842|uniprotkb:Q9UG09|uniprotkb:Q9Y3U4|ensembl:ENSP00000299980|ensembl:ENSP00000454523	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap1g1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:AP1G1(gene name)|psi-mi:AP1G1(display_short)|uniprotkb:ADTG(gene name synonym)|uniprotkb:CLAPG1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001025178.1|refseq:NP_001119.3|ensembl:ENSG00000166747(gene)|ensembl:ENST00000299980(transcript)|ensembl:ENST00000569748(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:O43747|rcsb pdb:1IU1|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E0niV91xZ1PV6Pr6Koq3Xs+9nKg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92538	intact:EBI-1257113	intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86UW7	intact:EBI-1257113	intact:EBI-308769|uniprotkb:Q658Q2|uniprotkb:Q7Z5T7|uniprotkb:Q8IZW9|uniprotkb:Q8N7M4|uniprotkb:Q9H6P4|uniprotkb:Q9HCI1|uniprotkb:Q9NWK8|uniprotkb:A4D0X3|uniprotkb:B7ZM56|ensembl:ENSP00000398481	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:caps2_human(display_long)|uniprotkb:KIAA1591(gene name synonym)|uniprotkb:CADPS2(gene name)|psi-mi:CADPS2(display_short)|uniprotkb:Calcium-dependent activator protein for secretion 2(gene name synonym)|uniprotkb:CAPS2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001009571.2|refseq:NP_001161412.1|refseq:NP_060424.9|ensembl:ENSG00000081803(gene)|ensembl:ENST00000449022(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990504"(dense core granule exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR033227|mint:Q86UW7|interpro:IPR035892	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f6jQKWbbAM0fC3mlwTazEbDh8ME9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7Z4F1	intact:EBI-1257113	intact:EBI-2830349|uniprotkb:Q8NCZ4|uniprotkb:Q9HC42|uniprotkb:O95882|uniprotkb:Q14CK7|uniprotkb:Q9UG33|uniprotkb:Q86T02|uniprotkb:A8K4R5|uniprotkb:D3DS31|ensembl:ENSP00000352601	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lrp10_human(display_long)|uniprotkb:LRP10(gene name)|psi-mi:LRP10(display_short)|uniprotkb:MSTP087(orf name)|uniprotkb:SP220(orf name)|uniprotkb:UNQ389/PRO724(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000352601|ensembl:ENST00000546834|ensembl:ENSP00000447559|ensembl:ENSG00000197324(gene)|ensembl:ENST00000359591(transcript)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048839"(inner ear development)|interpro:IPR000859(CUB)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR035914|interpro:IPR036055|reactome:R-HSA-975634|interpro:IPR023415|refseq:NP_054764.2|refseq:NP_001316155.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wXlXHoFbJyH8IwNBjkXzb81X3pA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WWN9	intact:EBI-1257113	intact:EBI-4401965|uniprotkb:A8K1K2|uniprotkb:B7ZL78|uniprotkb:B7ZL80|uniprotkb:O43153|uniprotkb:Q5HYL8|uniprotkb:G3V132|ensembl:ENSP00000265198	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:icef1_human(display_long)|uniprotkb:IPCEF1(gene name)|psi-mi:IPCEF1(display_short)|uniprotkb:KIAA0403(gene name synonym)|uniprotkb:Phosphoinositide-binding protein PIP3-E(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001124171.1|refseq:NP_001124172.1|refseq:NP_056368.1|refseq:XP_011534044.1|ensembl:ENSP00000265198|ensembl:ENST00000367220|ensembl:ENSP00000356189|ensembl:ENST00000422970|ensembl:ENSP00000394751|refseq:XP_005266976.1|refseq:XP_005266978.1|refseq:XP_005266980.1|refseq:XP_016866206.1|refseq:XP_016866207.1|ensembl:ENSG00000074706(gene)|ensembl:ENST00000265198(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0015671"(oxygen transport)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:5MR1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mCPbsOqozR5PU1lUnhR19O7ngQo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q658P3	intact:EBI-1257113	intact:EBI-3933105|uniprotkb:Q86SF6|uniprotkb:Q9NVB5|uniprotkb:A8K6E3|uniprotkb:Q8TF03|uniprotkb:Q8TDP3|uniprotkb:Q4VBR2|uniprotkb:Q8NEW6|uniprotkb:Q53SQ8|uniprotkb:Q7Z389|uniprotkb:Q4ZG36|ensembl:ENSP00000376818|ensembl:ENSP00000376819	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stea3_human(display_long)|uniprotkb:STEAP3(gene name)|psi-mi:STEAP3(display_short)|uniprotkb:TSAP6(gene name synonym)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:pHyde(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011509705.1|refseq:NP_619543.2|ensembl:ENSG00000115107(gene)|ensembl:ENST00000393106(transcript)|ensembl:ENST00000393107(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016723"(oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor)|go:"GO:0033572"(transferrin transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|interpro:IPR036291|rcsb pdb:2VNS|rcsb pdb:2VQ3|reactome:R-HSA-6803204|reactome:R-HSA-9013148|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-917977|go:"GO:0006915"(apoptotic process)|refseq:NP_001008410.1|refseq:NP_060704.2|refseq:NP_878919.2|refseq:XP_006712677.1|refseq:XP_006712678.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fZmXHidOHx0fIw1WYbsyliQcZVA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5KSL6	intact:EBI-1257113	intact:EBI-4401920|uniprotkb:B2RP91|ensembl:ENSP00000477515	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dgkk_human(display_long)|uniprotkb:DGKK(gene name)|psi-mi:DGKK(display_short)|uniprotkb:142 kDa diacylglycerol kinase(gene name synonym)|uniprotkb:Diglyceride kinase kappa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001013764.1|ensembl:ENSG00000274588(gene)|ensembl:ENST00000611977(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR037607|reactome:R-HSA-114508	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fKrx6UqiuVgIq8Zxtd/tUPhMqtI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13277	intact:EBI-1257113	intact:EBI-1394295|uniprotkb:O43750|uniprotkb:O43751|uniprotkb:Q15360|uniprotkb:B4DME0|ensembl:ENSP00000338562	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx3_human(display_long)|uniprotkb:STX3(gene name)|psi-mi:STX3(display_short)|uniprotkb:STX3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004168.1|refseq:NP_001171511.1|refseq:XP_005274252.1|refseq:XP_005274257.1|ensembl:ENSG00000166900(gene)|ensembl:ENST00000337979(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR031186|mint:Q13277|reactome:R-HSA-449836	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M/ue1L+l8LnUJNpEWVZ/KWR5UjM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27449	intact:EBI-1257113	intact:EBI-721179|uniprotkb:Q6FH26|ensembl:ENSP00000329757	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatl_human(display_long)|uniprotkb:ATP6V0C(gene name)|psi-mi:ATP6V0C(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6L(gene name synonym)|uniprotkb:ATPL(gene name synonym)|uniprotkb:Vacuolar proton pump 16 kDa proteolipid subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185498.1|refseq:NP_001685.1|ensembl:ENSG00000185883(gene)|ensembl:ENST00000330398(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|mint:P27449|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SENUYPVXYqkUWD9OawRSREg3SZk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NEY4	intact:EBI-1257113	intact:EBI-2819359|uniprotkb:Q96EL8|ensembl:ENSP00000272238	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatc2_human(display_long)|uniprotkb:ATP6V1C2(gene name)|psi-mi:ATP6V1C2(display_short)|uniprotkb:Vacuolar proton pump subunit C 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034451.1|refseq:NP_653184.2|refseq:XP_016859234.1|ensembl:ENSG00000143882(gene)|ensembl:ENST00000272238(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H+hwHCy4W4xN0UP/8v0kXAK7NUA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BW19	intact:EBI-1257113	intact:EBI-2107279|uniprotkb:O60887|uniprotkb:Q14834|uniprotkb:Q4KMP0|uniprotkb:Q5SU09|uniprotkb:Q6GMS7|uniprotkb:Q6P4A5|uniprotkb:Q9UQP7|ensembl:ENSP00000363647|ensembl:ENSP00000393963|ensembl:ENSP00000407885	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kifc1_human(display_long)|uniprotkb:KIFC1(gene name)|psi-mi:KIFC1(display_short)|uniprotkb:HSET(gene name synonym)|uniprotkb:KNSL2(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-related protein HSET(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002254.2|ensembl:ENSG00000204197(gene)|ensembl:ENSG00000233450(gene)|ensembl:ENSG00000237649(gene)|ensembl:ENST00000374523(transcript)|ensembl:ENST00000428849(transcript)|ensembl:ENST00000448818(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q9BW19|rcsb pdb:5WDH|reactome:R-HSA-6811434|reactome:R-HSA-983189	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2gWpNwZk9kWJGVvR8xLuDPJYP4M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50552	intact:EBI-1257113	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HB19	intact:EBI-1257113	intact:EBI-4401947	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkha2_human(display_long)|uniprotkb:PLEKHA2(gene name)|psi-mi:PLEKHA2(display_short)|uniprotkb:TAPP2(gene name synonym)|uniprotkb:Tandem PH domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_067636.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|reactome:R-HSA-1660499|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gaDNQEdJ1GwHMQcxHJxP+GIaaXE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6T310	intact:EBI-1257113	intact:EBI-4401868|uniprotkb:B2RN97|ensembl:ENSP00000241463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rslba_human(display_long)|uniprotkb:RASL11A(gene name)|psi-mi:RASL11A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_996563.1|refseq:NP_001318055.1|ensembl:ENSG00000122035(gene)|ensembl:ENST00000241463(transcript)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ud04zEeBRq4Cf9UwbuZNEg+fKew9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96SB3	intact:EBI-1257113	intact:EBI-351275|uniprotkb:Q8TCR9|intact:EBI-28984643|ensembl:ENSP00000478767|intact:EBI-4401886|uniprotkb:D3DTX6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:neb2_human(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:PPP1R9B(gene name)|psi-mi:PPP1R9B(display_short)|uniprotkb:PPP1R6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000108819(gene)|ensembl:ENST00000612501(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q96SB3|ensembl:ENSP00000478767|refseq:NP_115984.3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:X6fQLpaYhXCqzRlQNEoX67P/HbU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6XZF7	intact:EBI-1257113	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14662	intact:EBI-1257113	intact:EBI-2853548|uniprotkb:B7ZBN3|uniprotkb:O14663|uniprotkb:Q5W086|uniprotkb:A6NN69|uniprotkb:Q9H0Z0|uniprotkb:O60517|uniprotkb:Q9UIX5|uniprotkb:Q5W087|uniprotkb:Q5XKI6|uniprotkb:Q5W084|uniprotkb:B7ZBN1|uniprotkb:B7ZBN2|uniprotkb:O14661|uniprotkb:Q9H1T7|uniprotkb:Q9H1T8|uniprotkb:E1P607|uniprotkb:A6NK32|uniprotkb:A8MPP0|uniprotkb:Q6GMS8|uniprotkb:E1P5M0|ensembl:ENSP00000360183	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx16_human(display_long)|uniprotkb:STX16(gene name)|psi-mi:STX16(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001001433.1|refseq:NP_001128245.1|refseq:NP_001191797.1|refseq:NP_003754.2|refseq:NP_001128244.1|dip:DIP-57570N|ensembl:ENSG00000124222(gene)|ensembl:ENST00000371141(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028673|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pJ1TuU8Jl4SqtRPMYNCV0ZO0pRY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q03001-3	intact:EBI-1257113	intact:EBI-433556|ensembl:ENSP00000359801	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q03001-3(display_long)|uniprotkb:BPAG1e(isoform synonym)|uniprotkb:eBPAG1(isoform synonym)|uniprotkb:BP230(gene name synonym)|uniprotkb:BP240(gene name synonym)|uniprotkb:230/240 kDa bullous pemphigoid antigen(gene name synonym)|uniprotkb:DST(gene name)|psi-mi:DST(display_short)|uniprotkb:BPAG1(gene name synonym)|uniprotkb:DMH(gene name synonym)|uniprotkb:DT(gene name synonym)|uniprotkb:KIAA0728(gene name synonym)|uniprotkb:230 kDa bullous pemphigoid antigen(gene name synonym)|uniprotkb:Dystonia musculorum protein(gene name synonym)|uniprotkb:Bullous pemphigoid antigen 1(gene name synonym)|uniprotkb:Hemidesmosomal plaque protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-310758(bpaea_human)|ensembl:ENSG00000151914(gene)|ensembl:ENST00000370765(transcript)|uniprotkb:Q03001-3(isoform-parent)	-	-	isoform-comment:"Ref.1 (M69225) sequence is in conflict in position: 1644:R->T. Ref.1 (M69225) sequence is in conflict in position: 2364:S->T. Ref.1 (M69225) sequence is in conflict in position: 2495:G->V. Ref.1 (M69225) sequence is in conflict in position: 2543:N->K. Ref.1 (M69225) sequence is in conflict in position: 2621:A->P. Ref.13 (CAA41528) sequence is in conflict in position: 1943:G->R. Contains a phosphoserine at position 1565."|isoform-comment:"Ref.1 (M69225) sequence is in conflict in position: 1644:R->T. Ref.1 (M69225) sequence is in conflict in position: 2364:S->T. Ref.1 (M69225) sequence is in conflict in position: 2495:G->V. Ref.1 (M69225) sequence is in conflict in position: 2543:N->K. Ref.1 (M69225) sequence is in conflict in position: 2621:A->P. Ref.13 (CAA41528) sequence is in conflict in position: 1943:G->R. Contains a phosphoserine at position 1565."	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LaBOSXSMc95XWzjA54FpWpccFqI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UH65	intact:EBI-1257113	intact:EBI-310749|uniprotkb:O75135|uniprotkb:Q7LCY6|uniprotkb:Q9P061|uniprotkb:Q9P0Z8|uniprotkb:D3DQV1|ensembl:ENSP00000315630	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:swp70_human(display_long)|uniprotkb:KIAA0640(gene name synonym)|uniprotkb:SWAP70(gene name)|psi-mi:SWAP70(display_short)|uniprotkb:HSPC321(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055870.2|refseq:NP_001284643.1|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2DN6|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000133789(gene)|ensembl:ENST00000318950(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0045190"(isotype switching)|go:"GO:0045296"(cadherin binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GU1JyBHhrTRPDnzRBSIJeP8d4ZE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6IQ23	intact:EBI-1257113	intact:EBI-2125301|uniprotkb:Q86VZ7|uniprotkb:B4DK33|uniprotkb:B4DWC3|intact:EBI-28977101|ensembl:ENSP00000347883	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkha7_human(display_long)|uniprotkb:PLEKHA7(gene name)|psi-mi:PLEKHA7(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_778228.3|ensembl:ENSP00000347883|refseq:NP_001316559.1|refseq:NP_001316560.1|ensembl:ENSG00000166689(gene)|ensembl:ENST00000355661(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005915"(zonula adherens)|go:"GO:0030054"(cell junction)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR040392|rcsb pdb:7KJO|rcsb pdb:7KJZ|rcsb pdb:7KK7	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AqLJ+GSULYT7MByw7FZAgPXxir49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15276	intact:EBI-1257113	intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:B4DIP2	intact:EBI-1257113	intact:EBI-4401894|ensembl:ENSP00000397833	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:b4dip2_human(display_long)|uniprotkb:ERBIN(gene name)|psi-mi:ERBIN(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000112851(gene)|ensembl:ENST00000416865(transcript)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0007165"(signal transduction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:x5qSOBMnczp57AYWTG9hIqFtEVM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WZA2-2	intact:EBI-1257113	intact:EBI-4401857	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q8wza2-2(display_long)|uniprotkb:RAPGEF4(gene name)|psi-mi:RAPGEF4(display_short)|uniprotkb:CGEF2(gene name synonym)|uniprotkb:EPAC2(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 2(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 2(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-948476(isoform-parent)	-	-	isoform-comment:Produced by alternative promoter usage. Promoter analysis was carried out in mouse.	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HYcH53haICp6v/BGRFbBKQ22iyI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y4G6	intact:EBI-1257113	intact:EBI-1220811|uniprotkb:A6NLB8|ensembl:ENSP00000453508	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tln2_human(display_long)|uniprotkb:TLN2(gene name)|psi-mi:TLN2(display_short)|uniprotkb:KIAA0320(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055874.2|refseq:XP_016878157.1|dip:DIP-17039N|ensembl:ENSG00000171914(gene)|ensembl:ENST00000561311(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y4G6|rcsb pdb:6U4K	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/vkImDHugUJnyPtaJs/XfDyhXYo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P60468	intact:EBI-1257113	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40763	intact:EBI-1257113	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:A4D1S5	intact:EBI-1257113	intact:EBI-4401710|uniprotkb:A4D1S6|uniprotkb:B2RTS6|uniprotkb:B5MDR2|uniprotkb:Q9UL27|ensembl:ENSP00000348778|ensembl:ENSP00000440167	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab19_human(display_long)|uniprotkb:RAB19(gene name)|psi-mi:RAB19(display_short)|uniprotkb:RAB19B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008749.2|refseq:XP_016867696.1|refseq:XP_005250053.1|ensembl:ENSG00000146955(gene)|ensembl:ENST00000356407(transcript)|ensembl:ENST00000537763(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dc02Pzk2SmaerQsAEwIq6OcDQbM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14964	intact:EBI-1257113	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P22059	intact:EBI-1257113	intact:EBI-2681902|uniprotkb:Q6P524|ensembl:ENSP00000263847	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osbp1_human(display_long)|uniprotkb:OSBP1(gene name synonym)|uniprotkb:OSBP(gene name)|psi-mi:OSBP(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002547.1|ensembl:ENSG00000110048(gene)|ensembl:ENST00000263847(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|go:"GO:1904411"(positive regulation of secretory granule organization)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:2RR3|reactome:R-HSA-1660661|reactome:R-HSA-192105|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9LgzhfWQ0E/ECTTKA1OogQSyuAI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P29317	intact:EBI-1257113	intact:EBI-702104|uniprotkb:Q8N3Z2|uniprotkb:B5A968|intact:EBI-28989000|ensembl:ENSP00000351209	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:epha2_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:EPHA2(gene name)|psi-mi:EPHA2(display_short)|uniprotkb:ECK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004422.2|ensembl:ENSP00000351209|dip:DIP-96N|ensembl:ENSG00000142627(gene)|ensembl:ENST00000358432(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:P29317|rcsb pdb:1MQB|rcsb pdb:2E8N|rcsb pdb:2K9Y|rcsb pdb:2KSO|rcsb pdb:2X10|rcsb pdb:2X11|rcsb pdb:3C8X|rcsb pdb:3CZU|rcsb pdb:3FL7|rcsb pdb:3HEI|rcsb pdb:3HPN|rcsb pdb:3KKA|rcsb pdb:3MBW|rcsb pdb:3MX0|rcsb pdb:3SKJ|rcsb pdb:4P2K|rcsb pdb:4PDO|rcsb pdb:4TRL|rcsb pdb:5EK7|rcsb pdb:5I9U|rcsb pdb:5I9V|rcsb pdb:5I9W|rcsb pdb:5I9X|rcsb pdb:5I9Y|rcsb pdb:5I9Z|rcsb pdb:5IA0|rcsb pdb:5IA1|rcsb pdb:5IA2|rcsb pdb:5IA3|rcsb pdb:5IA4|rcsb pdb:5IA5|rcsb pdb:5NJZ|rcsb pdb:5NK0|rcsb pdb:5NK1|rcsb pdb:5NK2|rcsb pdb:5NK3|rcsb pdb:5NK4|rcsb pdb:5NK5|rcsb pdb:5NK6|rcsb pdb:5NK7|rcsb pdb:5NK8|rcsb pdb:5NK9|rcsb pdb:5NKA|rcsb pdb:5NKB|rcsb pdb:5NKC|rcsb pdb:5NKD|rcsb pdb:5NKE|rcsb pdb:5NKF|rcsb pdb:5NKG|rcsb pdb:5NKH|rcsb pdb:5NKI|rcsb pdb:5NZ9|rcsb pdb:6B9L|rcsb pdb:6F7M|rcsb pdb:6F7N|rcsb pdb:6FNF|rcsb pdb:6FNG|rcsb pdb:6FNH|rcsb pdb:6HES|rcsb pdb:6HET|rcsb pdb:6HEU|rcsb pdb:6HEV|rcsb pdb:6HEW|rcsb pdb:6HEX|rcsb pdb:6HEY|rcsb pdb:6NJZ|rcsb pdb:6NK0|rcsb pdb:6NK1|rcsb pdb:6NK2|rcsb pdb:6NKP|rcsb pdb:6Q7B|rcsb pdb:6Q7C|rcsb pdb:6Q7D|rcsb pdb:6Q7E|rcsb pdb:6Q7F|rcsb pdb:6Q7G|rcsb pdb:6RW2|rcsb pdb:7B7N|rcsb pdb:7CZE|rcsb pdb:7CZF|rcsb pdb:7KJA|rcsb pdb:7KJB|rcsb pdb:7KJC|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9VFikLd4ftRmEyBpY0JHdpHINT09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6Q5	intact:EBI-1257113	intact:EBI-752250|uniprotkb:Q9BSI8|uniprotkb:B2RDV5|ensembl:ENSP00000250244	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap1m2_human(display_long)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-2 subunit(gene name synonym)|uniprotkb:Mu-adaptin 2(gene name synonym)|uniprotkb:AP-mu chain family member mu1B(gene name synonym)|uniprotkb:Mu1B-adaptin(gene name synonym)|uniprotkb:AP1M2(gene name)|psi-mi:AP1M2(display_short)|uniprotkb:Adaptor protein complex AP-1 subunit mu-2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-2(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-2 medium chain 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005489.2|refseq:NP_001287816.1|ensembl:ENSG00000129354(gene)|ensembl:ENST00000250244(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006903"(vesicle targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Zb94TVE2hogjzn1QKDV3vWRNsWo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y478	intact:EBI-1257113	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16513	intact:EBI-1257113	intact:EBI-2511350|uniprotkb:Q9H1W4|uniprotkb:D3DT24|uniprotkb:B4DQ21|uniprotkb:B4DTP5|uniprotkb:B4DVG1|uniprotkb:Q08AF4|ensembl:ENSP00000359552	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkn2_human(display_long)|uniprotkb:PKN2(gene name)|psi-mi:PKN2(display_short)|uniprotkb:PRK2(gene name synonym)|uniprotkb:PRKCL2(gene name synonym)|uniprotkb:Protein kinase C-like 2(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 2(gene name synonym)|uniprotkb:PKN gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011540074.1|refseq:NP_006247.1|refseq:NP_001307636.1|refseq:NP_001307637.1|refseq:NP_001307638.1|ensembl:ENSG00000065243(gene)|ensembl:ENST00000370521(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037784|mint:Q16513|rcsb pdb:4CRS|rcsb pdb:4RRV|rcsb pdb:6CCY|rcsb pdb:6GBE|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0032467"(positive regulation of cytokinesis)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KvHDOJ75CgHIGDC+41jGKORm2+w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6ZU15	intact:EBI-1257113	intact:EBI-2009297|uniprotkb:A6NCC2|uniprotkb:B4DXD6|ensembl:ENSP00000373627	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sep14_human(display_long)|uniprotkb:SEPTIN14(gene name)|psi-mi:SEPTIN14(display_short)|uniprotkb:SEPT14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011513675.1|refseq:NP_997249.2|ensembl:ENSG00000154997(gene)|ensembl:ENST00000388975(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005940"(septin ring)|go:"GO:0007286"(spermatid development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043204"(perikaryon)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GxZqjtsTi+/cViW7AUh07WfU2/Q9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BV40	intact:EBI-1257113	intact:EBI-727028|uniprotkb:O60625|uniprotkb:Q53SP9|uniprotkb:Q6IB09|ensembl:ENSP00000263864	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vamp8_human(display_long)|uniprotkb:Endobrevin(gene name synonym)|uniprotkb:VAMP8(gene name)|psi-mi:VAMP8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003752.2|ensembl:ENSG00000118640(gene)|ensembl:ENST00000263864(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|mint:Q9BV40|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-1236974|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|dip:DIP-40358N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DW/t33n6NkBelQt6H1QS5hUY5+E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P47712	intact:EBI-1257113	intact:EBI-1044090|uniprotkb:Q29R80|ensembl:ENSP00000356436|uniprotkb:B1AKG4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pa24a_human(display_long)|uniprotkb:PLA2G4A(gene name)|psi-mi:PLA2G4A(display_short)|uniprotkb:CPLA2(gene name synonym)|uniprotkb:PLA2G4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_077734.1|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|rcsb pdb:1BCI|rcsb pdb:1CJY|rcsb pdb:1RLW|reactome:R-HSA-111995|reactome:R-HSA-1482788|reactome:R-HSA-1482798|reactome:R-HSA-1482801|reactome:R-HSA-1482839|reactome:R-HSA-1482922|reactome:R-HSA-1482925|reactome:R-HSA-1483115|reactome:R-HSA-1483166|reactome:R-HSA-2142753|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-6811436|ensembl:ENSG00000116711(gene)|ensembl:ENST00000367466(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0006690"(icosanoid metabolic process)|refseq:NP_001298122.1|refseq:XP_011507944.1|dip:DIP-40991N	-	-	crc64:EE71CA0EBE617856	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:D/yM7EFWP6xaMQ//7wutJS5D3jw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WXI4	intact:EBI-1257113	intact:EBI-4401643|uniprotkb:B1AQ22|uniprotkb:D3DQ50|uniprotkb:O75187|uniprotkb:Q52LP1|uniprotkb:Q53ER9|uniprotkb:Q96DI1|uniprotkb:Q9H883|ensembl:ENSP00000360366|intact:EBI-28978874	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aco11_human(display_long)|uniprotkb:Palmitoyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:ACOT11(gene name)|psi-mi:ACOT11(display_short)|uniprotkb:BFIT(gene name synonym)|uniprotkb:KIAA0707(gene name synonym)|uniprotkb:THEA(gene name synonym)|uniprotkb:Acyl-CoA thioester hydrolase 11(gene name synonym)|uniprotkb:Adipose-associated thioesterase(gene name synonym)|uniprotkb:Brown fat-inducible thioesterase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056362.1|refseq:NP_671517.1|ensembl:ENST00000343744|ensembl:ENSP00000340260|ensembl:ENSP00000360366|ensembl:ENSG00000162390(gene)|ensembl:ENST00000371316(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009409"(response to cold)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR002913(Lipid-binding START)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR023393|interpro:IPR029069|interpro:IPR033120|interpro:IPR040170|rcsb pdb:3FO5|rcsb pdb:6VVQ|reactome:R-HSA-77289	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lpvW54MsMG75qGPXjmOKNbA9Azk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H6S3	intact:EBI-1257113	intact:EBI-3940939|uniprotkb:Q53GM8|uniprotkb:Q9H6K9|uniprotkb:B3KSX1|uniprotkb:Q96K06|uniprotkb:Q8WYW7|ensembl:ENSP00000320828|ensembl:ENSP00000435585|ensembl:ENSP00000436035|uniprotkb:B7ZKL3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:es8l2_human(display_long)|uniprotkb:EPS8L2(gene name)|psi-mi:EPS8L2(display_short)|uniprotkb:EPS8R2(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 2(gene name synonym)|uniprotkb:PP13181(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000177106(gene)|ensembl:ENST00000318562(transcript)|ensembl:ENST00000530636(transcript)|ensembl:ENST00000533256(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031982"(vesicle)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q9H6S3|rcsb pdb:1WWU|rcsb pdb:1WXB|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_073609.2|refseq:XP_016873619.1|refseq:XP_016873620.1|refseq:XP_016873621.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fm46f0tF2y2QGPLD7dk77JUHMXA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5JV73	intact:EBI-1257113	intact:EBI-4401756|uniprotkb:Q96JK8|ensembl:ENSP00000276185	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:frpd3_human(display_long)|uniprotkb:FRMPD3(gene name)|psi-mi:FRMPD3(display_short)|uniprotkb:KIAA1817(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115804.1|ensembl:ENST00000276185(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041779|reactome:R-HSA-6798695|ensembl:ENSG00000147234(gene)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RojtvQMY4MQmw6Mj4rw7ABfuiz09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15164	intact:EBI-1257113	intact:EBI-2130378|uniprotkb:O95854|uniprotkb:A4D1R7|uniprotkb:A4D1R8|ensembl:ENSP00000340507	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tif1a_human(display_long)|uniprotkb:TRIM24(gene name)|psi-mi:TRIM24(display_short)|uniprotkb:RNF82(gene name synonym)|uniprotkb:TIF1(gene name synonym)|uniprotkb:TIF1A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 24(gene name synonym)|uniprotkb:RING finger protein 82(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRIM24(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003843.3|refseq:NP_056989.2|dip:DIP-52713N|ensembl:ENSG00000122779(gene)|ensembl:ENST00000343526(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018359|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|mint:O15164|rcsb pdb:2YYN|rcsb pdb:3O33|rcsb pdb:3O34|rcsb pdb:3O35|rcsb pdb:3O36|rcsb pdb:3O37|go:"GO:0055074"(calcium ion homeostasis)|rcsb pdb:4YAB|rcsb pdb:4YAD|rcsb pdb:4YAT|rcsb pdb:4YAX|rcsb pdb:4YBM|rcsb pdb:4YBS|rcsb pdb:4YBT|rcsb pdb:4YC9|rcsb pdb:4ZQL|rcsb pdb:5H1T|rcsb pdb:5H1U|rcsb pdb:5H1V|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-6802952|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jfxCpemP8t6GF09CXu+bpmfZ2ng9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H082	intact:EBI-1257113	intact:EBI-3048549|ensembl:ENSP00000306496|uniprotkb:Q4W5B0|uniprotkb:B2R987	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rb33b_human(display_long)|uniprotkb:RAB33B(gene name)|psi-mi:RAB33B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000172007(gene)|ensembl:ENST00000305626(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903434"(negative regulation of constitutive secretory pathway)|go:"GO:2000156"(regulation of retrograde vesicle-mediated transport, Golgi to ER)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041822|rcsb pdb:6Y09|rcsb pdb:6ZAY|reactome:R-HSA-6811438|reactome:R-HSA-8854214|reactome:R-HSA-8873719|refseq:NP_112586.1|dip:DIP-61978N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:abTOfFzfOdw82bfp1EaZyJPjTDg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15126	intact:EBI-1257113	intact:EBI-954338|ensembl:ENSP00000481022|uniprotkb:O43587|uniprotkb:Q96BX1|uniprotkb:Q96QK5|uniprotkb:Q6FG23	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam1_human(display_long)|uniprotkb:SCAMP1(gene name)|psi-mi:SCAMP1(display_short)|uniprotkb:SCAMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000085365(gene)|ensembl:ENST00000621999(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|reactome:R-HSA-6798695|refseq:NP_004857.4|refseq:NP_001277158.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Utuf4fnpMHS2yG4zfccdB2enfxI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRL2	intact:EBI-1257113	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0T7	intact:EBI-1257113	intact:EBI-721615|uniprotkb:Q9BVU1|uniprotkb:Q9H9U9|intact:EBI-1048280|uniprotkb:Q53QV6|uniprotkb:Q6IA73|uniprotkb:Q6PJZ0|ensembl:ENSP00000264601	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab17_human(display_long)|uniprotkb:RAB17(gene name)|psi-mi:RAB17(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071894.1|ensembl:ENST00000264601(transcript)|go:"GO:0002415"(immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0032401"(establishment of melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045056"(transcytosis)|ensembl:ENSG00000124839(gene)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:O62O2JG/wQcm1OMlcEPg7Not7oU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BSK2	intact:EBI-1257113	intact:EBI-4401696|ensembl:ENSP00000306328	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:s2533_human(display_long)|uniprotkb:SLC25A33(gene name)|psi-mi:SLC25A33(display_short)|uniprotkb:Bone marrow stromal cell mitochondrial carrier protein(gene name synonym)|uniprotkb:Protein PNC1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115691.1|ensembl:ENSG00000171612(gene)|ensembl:ENST00000302692(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006864"(pyrimidine nucleotide transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015218"(pyrimidine nucleotide transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990519"(pyrimidine nucleotide import into mitochondrion)|interpro:IPR018108|interpro:IPR023395	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Rb5AjJ6sEC4LlD5WAJ0cbDjIlxY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96HS1	intact:EBI-1257113	intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HCE6	intact:EBI-1257113	intact:EBI-724864|uniprotkb:Q6P0L7|uniprotkb:Q8NAV5|uniprotkb:Q9NVT3|uniprotkb:Q17RW1|uniprotkb:Q3YFJ4|uniprotkb:Q5VXI5|uniprotkb:Q5VXI6|uniprotkb:Q66K51|uniprotkb:B7ZKS1|ensembl:ENSP00000355060	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:argal_human(display_long)|uniprotkb:GRINCHGEF(gene name synonym)|uniprotkb:KIAA1626(gene name synonym)|uniprotkb:GrinchGEF(gene name synonym)|uniprotkb:ARHGEF10L(gene name)|psi-mi:ARHGEF10L(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001306766.1|refseq:NP_001306767.1|refseq:NP_001011722.2|refseq:NP_060595.3|ensembl:ENSG00000074964(gene)|ensembl:ENST00000361221(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035899|interpro:IPR036322|interpro:IPR039919|refseq:NP_001315053.1|refseq:XP_005245982.2|refseq:XP_016857106.1|refseq:XP_016857110.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HWnqkCHhpqMiOEwoYw8Uhfn8N+w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86UR5	intact:EBI-1257113	intact:EBI-1043236|uniprotkb:B7Z3S3|uniprotkb:E7EX08|uniprotkb:E9PHR1|uniprotkb:Q5JY21|uniprotkb:O15048|uniprotkb:Q8TDY9|uniprotkb:Q8TDZ5|uniprotkb:Q9HBA1|uniprotkb:Q9HBA2|uniprotkb:Q9HBA3|uniprotkb:Q9HBA4|uniprotkb:Q9HBA5|uniprotkb:Q9HBA6|ensembl:ENSP00000428417|intact:EBI-1752690|intact:EBI-1957901|uniprotkb:A7MBN6|uniprotkb:Q5JY25|uniprotkb:Q5SZK1|uniprotkb:B7Z6S2|uniprotkb:E9PCB7|uniprotkb:E9PCZ1|uniprotkb:B7Z2M0|uniprotkb:B7Z2Q9|uniprotkb:E9PF48|uniprotkb:E9PHF5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rims1_human(display_long)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)|uniprotkb:RIMS1(gene name)|psi-mi:RIMS1(display_short)|uniprotkb:KIAA0340(gene name synonym)|uniprotkb:RIM1(gene name synonym)|uniprotkb:Nbla00761(orf name)|uniprotkb:RAB3IP2(gene name synonym)|uniprotkb:Rab-3-interacting protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000079841(gene)|ensembl:ENST00000521978(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007601"(visual perception)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050896"(response to stimulus)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:2CSS|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-888590|refseq:NP_055804.2|refseq:NP_001161882.1|refseq:XP_011533917.2|refseq:NP_001161883.1|refseq:NP_001161879.1|refseq:NP_001161880.1|refseq:NP_001161881.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hWekc+DUzy3KU1S8wADJedZk/SY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NSY2	intact:EBI-1257113	intact:EBI-4401592|uniprotkb:P59094|ensembl:ENSP00000304032	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:star5_human(display_long)|uniprotkb:STARD5(gene name)|psi-mi:STARD5(display_short)|uniprotkb:START domain-containing protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_871629.1|ensembl:ENSG00000172345(gene)|ensembl:ENST00000302824(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0015485"(cholesterol binding)|go:"GO:0032052"(bile acid binding)|go:"GO:0070508"(cholesterol import)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR002913(Lipid-binding START)|interpro:IPR023393|interpro:IPR029868|interpro:IPR043556|rcsb pdb:2R55|reactome:R-HSA-159418	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Fgh2PZNIkCLit2RLnu144/jasUk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BJ3	intact:EBI-1257113	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43491	intact:EBI-1257113	intact:EBI-1052044|uniprotkb:Q5T4F0|uniprotkb:B4DHI8|uniprotkb:Q68DV2|uniprotkb:E9PPD9|ensembl:ENSP00000338481|ensembl:ENSP00000357110	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:e41l2_human(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:EPB41L2(gene name)|psi-mi:EPB41L2(display_short)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001422.1|refseq:NP_001129026.1|refseq:NP_001129027.1|refseq:NP_001239589.1|refseq:XP_011533832.1|refseq:XP_011533836.1|ensembl:ENSG00000079819(gene)|ensembl:ENST00000337057(transcript)|ensembl:ENST00000368128(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0008091"(spectrin)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O43491|reactome:R-HSA-6794361|refseq:XP_016865844.1|refseq:XP_016865848.1|refseq:XP_016865849.1|refseq:XP_016865850.1|refseq:XP_016865851.1|dip:DIP-17034N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QvhY6g+bBqTBR8oHl/php27Wb7Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P08758	intact:EBI-1257113	intact:EBI-296601|ensembl:ENSP00000296511|uniprotkb:Q6FI16|uniprotkb:Q8WV69|uniprotkb:Q6FHB3|uniprotkb:Q9UDH9|uniprotkb:D3DNW7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa5_human(display_long)|uniprotkb:ANXA5(gene name)|psi-mi:ANXA5(display_short)|uniprotkb:ANX5(gene name synonym)|uniprotkb:ENX2(gene name synonym)|uniprotkb:PP4(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000164111(gene)|ensembl:ENST00000296511(transcript)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0016020"(membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P08758|rcsb pdb:1ANW|rcsb pdb:1ANX|rcsb pdb:1AVH|rcsb pdb:1AVR|rcsb pdb:1HAK|rcsb pdb:1HVD|rcsb pdb:1HVE|rcsb pdb:1HVF|rcsb pdb:1HVG|rcsb pdb:1SAV|rcsb pdb:2XO2|rcsb pdb:2XO3|rcsb pdb:6K22|rcsb pdb:6K25|reactome:R-HSA-114608|refseq:NP_001145.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vIp2wWkAz7uOtQSzbUJick5bT5o9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BT09	intact:EBI-1257113	intact:EBI-2835965|uniprotkb:Q8NF54|uniprotkb:Q0P6I2|uniprotkb:Q9P0F2|uniprotkb:Q8WTU8|uniprotkb:O15412|ensembl:ENSP00000361926	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cnpy3_human(display_long)|uniprotkb:CNPY3(gene name)|psi-mi:CNPY3(display_short)|uniprotkb:CTG4A(gene name synonym)|uniprotkb:ERDA5(gene name synonym)|uniprotkb:PRAT4A(gene name synonym)|uniprotkb:TNRC5(gene name synonym)|uniprotkb:CTG repeat protein 4a(gene name synonym)|uniprotkb:Expanded repeat-domain protein CAG/CTG 5(gene name synonym)|uniprotkb:Protein associated with TLR4(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 5 protein(gene name synonym)|uniprotkb:HSPC084(orf name)|uniprotkb:UNQ1934/PRO4409(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000137161(gene)|ensembl:ENST00000372836(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0045087"(innate immune response)|interpro:IPR021852|reactome:R-HSA-1679131|refseq:NP_006577.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xE9+j0b39STiKRD5kjTzDatG0uk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96T23	intact:EBI-1257113	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43633	intact:EBI-1257113	intact:EBI-2692789|uniprotkb:B2R4W6|uniprotkb:Q3ZTT0|ensembl:ENSP00000310440|ensembl:ENSP00000469240|ensembl:ENSP00000472680	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chm2a_human(display_long)|uniprotkb:BC2(gene name synonym)|uniprotkb:CHMP2(gene name synonym)|uniprotkb:Chromatin-modifying protein 2a(gene name synonym)|uniprotkb:Putative breast adenocarcinoma marker BC-2(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-1(gene name synonym)|uniprotkb:CHMP2A(gene name)|psi-mi:CHMP2A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055268.1|refseq:NP_940818.1|ensembl:ENSG00000130724(gene)|ensembl:ENST00000312547(transcript)|ensembl:ENST00000600118(transcript)|ensembl:ENST00000601220(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010324"(membrane invagination)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:O43633|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-432720|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-48533N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S5uZThg//3igYMf6LLYDJ/FVGRA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15042	intact:EBI-1257113	intact:EBI-1053078|uniprotkb:Q659F5|uniprotkb:Q8TBB4|uniprotkb:C9J837|ensembl:ENSP00000264158|uniprotkb:A6H8Z3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rb3gp_human(display_long)|uniprotkb:RAB3 GTPase-activating protein 130 kDa subunit(gene name synonym)|uniprotkb:Rab3-GAP p130(gene name synonym)|uniprotkb:RAB3GAP1(gene name)|psi-mi:RAB3GAP1(display_short)|uniprotkb:KIAA0066(gene name synonym)|uniprotkb:RAB3GAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036365.1|ensembl:ENSG00000115839(gene)|ensembl:ENST00000264158(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098794"(postsynapse)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR026147|reactome:R-HSA-6811436|reactome:R-HSA-8876198|refseq:NP_001165906.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JCtnJX01timbIenQexwG84yBu2I9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14839	intact:EBI-1257113	intact:EBI-372916|uniprotkb:Q8IXZ5|intact:EBI-28978241|ensembl:ENSP00000440542	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chd4_human(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000440542|ensembl:ENST00000645095|ensembl:ENSP00000496634|refseq:NP_001264.2|refseq:XP_006719021.1|refseq:NP_001284482.1|ensembl:ENSG00000111642(gene)|ensembl:ENST00000544040(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016581"(NuRD complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043044"|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070615"|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:Q14839|rcsb pdb:1MM2|rcsb pdb:1MM3|rcsb pdb:2EE1|rcsb pdb:2L5U|rcsb pdb:2L75|rcsb pdb:2N5N|rcsb pdb:4O9I|rcsb pdb:6BGG|rcsb pdb:6Q3M|rcsb pdb:6RYR|rcsb pdb:6RYU|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9031628|reactome:R-HSA-9679191|dip:DIP-31183N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E9eHT/41SIFRiz54J81hvPQeHIE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HBF4	intact:EBI-1257113	intact:EBI-4401611|uniprotkb:Q8WYX7|uniprotkb:Q96K57|uniprotkb:Q9BXP9|uniprotkb:Q9HCI3|uniprotkb:J3KNL9|ensembl:ENSP00000450742	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zfyv1_human(display_long)|uniprotkb:ZFYVE1(gene name)|psi-mi:ZFYVE1(display_short)|uniprotkb:DFCP1(gene name synonym)|uniprotkb:KIAA1589(gene name synonym)|uniprotkb:TAFF1(gene name synonym)|uniprotkb:ZNFN2A1(gene name synonym)|uniprotkb:Double FYVE-containing protein 1(gene name synonym)|uniprotkb:SR3(gene name synonym)|uniprotkb:Tandem FYVE fingers-1(gene name synonym)|uniprotkb:PP10436(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016876862.1|refseq:NP_067083.1|refseq:NP_848535.1|refseq:NP_001268663.1|refseq:NP_001268664.1|ensembl:ENSG00000165861(gene)|ensembl:ENST00000556143(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005811"(lipid droplet)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016236"(macroautophagy)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990462"(omegasome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR027417|interpro:IPR042427	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RjtNZQqOYzwdILGqkyavUWHPB5Q9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UI14	intact:EBI-1257113	intact:EBI-712367|ensembl:ENSP00000222008|uniprotkb:Q7Z4Y2|uniprotkb:Q9Y3R1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:praf1_human(display_long)|uniprotkb:PRA1 family protein 1(gene name synonym)|uniprotkb:RABAC1(gene name)|psi-mi:RABAC1(display_short)|uniprotkb:PRA1(gene name synonym)|uniprotkb:PRAF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006414.2|ensembl:ENSG00000105404(gene)|ensembl:ENST00000222008(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:Q9UI14	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WS2rUY7yXRbR7pqWgfUCbnEiDbg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86YS6	intact:EBI-1257113	intact:EBI-4401730|uniprotkb:A8K4P9|uniprotkb:E9PBQ0|ensembl:ENSP00000319781|ensembl:ENSP00000376981|ensembl:ENSP00000376982|ensembl:ENSP00000376984|ensembl:ENSP00000376985	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab43_human(display_long)|uniprotkb:RAB43(gene name)|psi-mi:RAB43(display_short)|uniprotkb:RAB41(gene name synonym)|uniprotkb:Ras-related protein Rab-41(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001191816.1|refseq:NP_001191812.1|refseq:NP_001191813.1|refseq:NP_001191814.1|refseq:NP_001191815.1|refseq:NP_940892.1|ensembl:ENSG00000172780(gene)|ensembl:ENST00000315150(transcript)|ensembl:ENST00000393304(transcript)|ensembl:ENST00000393305(transcript)|ensembl:ENST00000393307(transcript)|ensembl:ENST00000393308(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035526"(retrograde transport, plasma membrane to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090382"(phagosome maturation)|go:"GO:1901998"(toxin transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2HUP|reactome:R-HSA-6811440|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Fnf/WvsSlD/a+UxyrO08zMSjpIo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9ULM0	intact:EBI-1257113	intact:EBI-2803624|uniprotkb:Q6ZWC7|uniprotkb:A6H8X6|uniprotkb:Q6PJL4|ensembl:ENSP00000330278	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkhh1_human(display_long)|uniprotkb:KIAA1200(gene name synonym)|uniprotkb:PLEKHH1(gene name)|psi-mi:PLEKHH1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000054690(gene)|ensembl:ENST00000329153(transcript)|go:"GO:0005856"(cytoskeleton)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR038185|interpro:IPR040105|refseq:NP_065766.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ONtvImmlJVWndi7ktHfkGZ1odWw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q93096	intact:EBI-1257113	intact:EBI-1058467|uniprotkb:O00648|uniprotkb:Q49A54|uniprotkb:B2R6C8|intact:EBI-1640492|ensembl:ENSP00000485687|ensembl:ENSP00000497588|ensembl:ENSP00000500859|ensembl:ENSP00000500952	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tp4a1_human(display_long)|uniprotkb:PTP4A1(gene name)|psi-mi:PTP4A1(display_short)|uniprotkb:PRL1(gene name synonym)|uniprotkb:PTPCAAX1(gene name synonym)|uniprotkb:"PTP(CAAXI)"(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 4a1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase of regenerating liver 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003454.1|ensembl:ENSG00000112245(gene)|ensembl:ENST00000626021(transcript)|ensembl:ENST00000648894(transcript)|ensembl:ENST00000672924(transcript)|ensembl:ENST00000673199(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1RXD|rcsb pdb:1XM2|rcsb pdb:5BX1|refseq:XP_016866759.1|refseq:XP_016866760.1|refseq:XP_011534413.1|refseq:XP_011534414.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Eza5NsYNd+5ml6QEEmkQv5pAZ789606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9ULC3	intact:EBI-1257113	intact:EBI-3924693|uniprotkb:Q8NI06|uniprotkb:B2R9I5|uniprotkb:Q68DJ6|uniprotkb:Q9P023|ensembl:ENSP00000320413|ensembl:ENSP00000417610	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab23_human(display_long)|uniprotkb:RAB23(gene name)|psi-mi:RAB23(display_short)|uniprotkb:HSPC137(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057361.3|refseq:NP_899050.1|ensembl:ENSG00000112210(gene)|ensembl:ENST00000317483(transcript)|ensembl:ENST00000468148(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006968"(cellular defense response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0030054"(cell junction)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0060271"(cilium assembly)|go:"GO:0097094"(craniofacial suture morphogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR034114|reactome:R-HSA-8873719|refseq:NP_001265595.1|refseq:NP_001265596.1|refseq:NP_001265597.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qlgGUzRqY7x3ZT9A/76QMFnaR109606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60784	intact:EBI-1257113	intact:EBI-74634|intact:EBI-28971074|ensembl:ENSP00000394466|uniprotkb:Q5TIJ6|uniprotkb:B4DEL9|uniprotkb:B4DNA1|uniprotkb:Q86X74	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tom1_human(display_long)|uniprotkb:TOM1(gene name)|psi-mi:TOM1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100284(gene)|ensembl:ENST00000449058(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030276"(clathrin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008942(ENTH/VHS)|interpro:IPR014645(Target of Myb protein 1)|interpro:IPR038425|mint:O60784|ensembl:ENST00000411850|ensembl:ENSP00000413697|ensembl:ENST00000425375|ensembl:ENSP00000394924|ensembl:ENST00000447733|ensembl:ENSP00000398876|ensembl:ENSP00000394466|refseq:NP_001129201.1|refseq:NP_001129202.1|refseq:NP_001129204.1|refseq:NP_005479.1|rcsb pdb:1ELK|rcsb pdb:1WRD|rcsb pdb:2N2N|rcsb pdb:2N9D|rcsb pdb:6J56|reactome:R-HSA-6798695|dip:DIP-30844N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MLXfzLA4x1/vwxwbzO5zowzkOtU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27986	intact:EBI-1257113	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12979	intact:EBI-1257113	intact:EBI-489922|uniprotkb:Q13693|uniprotkb:Q13694|uniprotkb:D3DTH4|uniprotkb:D3DTH3|uniprotkb:B3KW89|uniprotkb:F5H8B3|uniprotkb:B7Z6H7|uniprotkb:F5H3S2|ensembl:ENSP00000303909|ensembl:ENSP00000481740	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:abr_human(display_long)|uniprotkb:ABR(gene name)|psi-mi:ABR(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001153218.1|refseq:NP_001083.2|refseq:NP_068781.2|refseq:NP_001243776.1|refseq:NP_001269078.1|refseq:NP_001309769.1|ensembl:ENSG00000159842(gene)|ensembl:ENSG00000278741(gene)|ensembl:ENST00000302538(transcript)|ensembl:ENST00000612118(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR035892|interpro:IPR035899|interpro:IPR037769|interpro:IPR037865|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BE2zC9wZOEogjE9LQ3S3D5lIqGs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRY4	intact:EBI-1257113	intact:EBI-766200|uniprotkb:Q14452|uniprotkb:Q9C0E1|uniprotkb:A7E2A4|ensembl:ENSP00000385720|ensembl:ENSP00000483730|ensembl:ENSP00000500409	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg35_human(display_long)|uniprotkb:Glucocorticoid receptor repression factor 1(gene name synonym)|uniprotkb:Rho GAP p190A(gene name synonym)|uniprotkb:Glucocorticoid receptor DNA-binding factor 1(gene name synonym)|uniprotkb:GRF1(gene name synonym)|uniprotkb:KIAA1722(gene name synonym)|uniprotkb:ARHGAP35(gene name)|psi-mi:ARHGAP35(display_short)|uniprotkb:GRLF1(gene name synonym)|uniprotkb:P190A(gene name synonym)|uniprotkb:p190ARHOGAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004482.4|refseq:XP_016882203.1|dip:DIP-34578N|ensembl:ENSG00000160007(gene)|ensembl:ENST00000404338(transcript)|ensembl:ENST00000614079(transcript)|ensembl:ENST00000672722(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003677"(DNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030879"(mammary gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0097485"(neuron projection guidance)|interpro:IPR000198(RhoGAP)|interpro:IPR001806(Ras GTPase)|interpro:IPR002713(FF)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027417|interpro:IPR032835|interpro:IPR036517|interpro:IPR039006|interpro:IPR039007|rcsb pdb:2K85|rcsb pdb:3C5H|rcsb pdb:3FK2|rcsb pdb:6PXC|rcsb pdb:6WAY|reactome:R-HSA-416550|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QvhQwcov1A+SZ0qmVnhVebJ30rg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P41214	intact:EBI-1257113	intact:EBI-1055793|uniprotkb:Q5SY40|uniprotkb:Q8IXV3|uniprotkb:Q96DG3|uniprotkb:Q96TG7|uniprotkb:Q9NR27|uniprotkb:Q9NSN0|uniprotkb:Q9NV18|uniprotkb:Q9NZ21|ensembl:ENSP00000271764	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:eif2d_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated antigen 56(gene name synonym)|uniprotkb:EIF2D(gene name)|psi-mi:EIF2D(display_short)|uniprotkb:HCA56(gene name synonym)|uniprotkb:LGTN(gene name synonym)|uniprotkb:Ligatin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001188407.1|refseq:NP_008824.2|ensembl:ENSG00000143486(gene)|ensembl:ENST00000271764(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR001950(Translation initiation factor SUI1)|interpro:IPR002478(PUA)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR015947(PUA-like)|interpro:IPR036877|interpro:IPR036885|interpro:IPR039757|interpro:IPR039759|interpro:IPR041366|rcsb pdb:5OA3|rcsb pdb:5OA9|rcsb pdb:5W2F	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:p7wBLAZglRxmmVdFyFNT2RPj+6Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42345	intact:EBI-1257113	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H269	intact:EBI-1257113	intact:EBI-2655929|uniprotkb:Q5JUB1|uniprotkb:Q8WU31|uniprotkb:Q96EE7|uniprotkb:Q96N92|uniprotkb:Q9H1Q4|uniprotkb:Q9H1Q5|ensembl:ENSP00000369810	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps16_human(display_long)|uniprotkb:VPS16(gene name)|psi-mi:VPS16(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_072097.2|refseq:NP_536338.1|ensembl:ENSG00000215305(gene)|ensembl:ENST00000380445(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR038132|mint:Q9H269|rcsb pdb:4BX9	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bm088LmFRv3w0wfvlPMFeottZkw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H1Y0	intact:EBI-1257113	intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75131	intact:EBI-1257113	intact:EBI-718988|uniprotkb:Q8IYA1|uniprotkb:A8KA47|ensembl:ENSP00000477590	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cpne3_human(display_long)|uniprotkb:Copine III(gene name synonym)|uniprotkb:CPNE3(gene name)|psi-mi:CPNE3(display_short)|uniprotkb:CPN3(gene name synonym)|uniprotkb:KIAA0636(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003900.1|refseq:XP_005251150.1|ensembl:ENSG00000085719(gene)|ensembl:ENST00000517490(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:O75131|reactome:R-HSA-1483206|reactome:R-HSA-6798695|refseq:XP_016869434.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:75lb/sKHpJYCwCLIq973pzNMfzw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15155	intact:EBI-1257113	intact:EBI-749204|uniprotkb:Q96EA0|ensembl:ENSP00000222547	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bet1_human(display_long)|uniprotkb:Golgi vesicular membrane-trafficking protein p18(gene name synonym)|uniprotkb:BET1(gene name)|psi-mi:BET1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005859.1|refseq:NP_001304668.1|ensembl:ENSG00000105829(gene)|ensembl:ENST00000222547(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR039897|interpro:IPR039899|rcsb pdb:3EGX|reactome:R-HSA-204005|reactome:R-HSA-6807878|go:"GO:0031201"(SNARE complex)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:q+HguYhGwObsWqPGNyIVXf/YHO49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00471	intact:EBI-1257113	intact:EBI-949824|ensembl:ENSP00000484855|uniprotkb:B2R6C5|intact:EBI-10171392|uniprotkb:Q8IW24	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc5_human(display_long)|uniprotkb:Exocyst complex component Sec10(gene name synonym)|uniprotkb:EXOC5(gene name)|psi-mi:EXOC5(display_short)|uniprotkb:SEC10(gene name synonym)|uniprotkb:SEC10L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000070367(gene)|ensembl:ENST00000621441(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904019"(epithelial cell apoptotic process)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR009976(Exocyst complex component Sec10)|interpro:IPR033960|mint:O00471|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_006535.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UaEk0DAH+boE9+hl8z3VUUI78dM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P54619	intact:EBI-1257113	intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96KP1	intact:EBI-1257113	intact:EBI-465715|uniprotkb:Q5JPC8|uniprotkb:Q96AN6|uniprotkb:Q9NUZ8|uniprotkb:Q9UJM7|ensembl:ENSP00000230449|uniprotkb:B2RBE6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc2_human(display_long)|uniprotkb:EXOC2(gene name)|psi-mi:EXOC2(display_short)|uniprotkb:SEC5(gene name synonym)|uniprotkb:SEC5L1(gene name synonym)|uniprotkb:Exocyst complex component Sec5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000112685(gene)|ensembl:ENST00000230449(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR029175|interpro:IPR039481|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016866507.1|refseq:XP_016866508.1|refseq:XP_016866509.1|refseq:XP_016866510.1|refseq:XP_016866511.1|refseq:XP_016866512.1|refseq:XP_016866513.1|refseq:NP_060773.3|dip:DIP-31795N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:7p+4vZ18z6u2PJY0GzbHY+ro0v89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60493	intact:EBI-1257113	intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P0L0	intact:EBI-1257113	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P0V9	intact:EBI-1257113	intact:EBI-3943788|uniprotkb:B3KRQ9|uniprotkb:Q86VP5|uniprotkb:Q9HAH6|ensembl:ENSP00000380824	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sep10_human(display_long)|uniprotkb:SEPTIN10(gene name)|psi-mi:SEPTIN10(display_short)|uniprotkb:SEPT10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_653311.1|refseq:NP_848699.1|refseq:NP_001308433.1|refseq:NP_001308425.1|refseq:NP_001308427.1|refseq:NP_001308434.1|refseq:NP_001308435.1|refseq:NP_001308428.1|refseq:NP_001308436.1|refseq:NP_001308429.1|refseq:NP_001308437.1|refseq:NP_001308438.1|refseq:NP_001308439.1|refseq:NP_001308430.1|refseq:NP_001308431.1|refseq:NP_001308432.1|refseq:NP_001308440.1|refseq:NP_001308441.1|go:"GO:0034613"(cellular protein localization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|ensembl:ENSG00000186522(gene)|ensembl:ENST00000397712(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/yRE0i+Q5BlAYMdl77BWUhFsQw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99538	intact:EBI-1257113	intact:EBI-2511794|ensembl:ENSP00000334052|ensembl:ENSP00000376911|uniprotkb:Q86TV2|uniprotkb:Q86TV3|uniprotkb:Q9BTY1|uniprotkb:O00123|intact:EBI-10963477	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lgmn_human(display_long)|uniprotkb:LGMN(gene name)|psi-mi:LGMN(display_short)|uniprotkb:PRSC1(gene name synonym)|uniprotkb:Asparaginyl endopeptidase(gene name synonym)|uniprotkb:Protease, cysteine 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100600(gene)|ensembl:ENST00000334869(transcript)|ensembl:ENST00000393218(transcript)|go:"GO:0003014"(renal system process)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0007613"(memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001096(Peptidase C13, legumain)|interpro:IPR043577|mint:Q99538|rcsb pdb:4AW9|rcsb pdb:4AWA|rcsb pdb:4AWB|rcsb pdb:4FGU|rcsb pdb:4N6N|rcsb pdb:4N6O|rcsb pdb:5LU8|rcsb pdb:5LU9|rcsb pdb:5LUA|rcsb pdb:5LUB|reactome:R-HSA-1679131|go:"GO:0040015"(negative regulation of multicellular organism growth)|reactome:R-HSA-196791|reactome:R-HSA-2132295|refseq:XP_005267919.1|refseq:XP_005267920.1|refseq:NP_001008530.1|refseq:NP_005597.3|refseq:XP_016876952.1|refseq:XP_016876953.1|refseq:XP_016876954.1|refseq:XP_016876955.1|refseq:XP_016876956.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:W2jPq8/peH5iXt1wmbm8lFnkJwM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14936	intact:EBI-1257113	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96FJ0	intact:EBI-1257113	intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P21283	intact:EBI-1257113	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96HP0	intact:EBI-1257113	intact:EBI-4401295|uniprotkb:A6H8X5|uniprotkb:Q7Z7P4|uniprotkb:Q9P2F2|intact:EBI-28986399|ensembl:ENSP00000294618	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dock6_human(display_long)|uniprotkb:DOCK6(gene name)|psi-mi:DOCK6(display_short)|uniprotkb:KIAA1395(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065863.2|ensembl:ENSP00000294618|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|ensembl:ENSG00000130158(gene)|ensembl:ENST00000294618(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3I/PTxZBJythUz5yzxfTIhhj5io9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UL25	intact:EBI-1257113	intact:EBI-1056039|uniprotkb:Q14466|uniprotkb:Q569H3|ensembl:ENSP00000261263	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab21_human(display_long)|uniprotkb:RAB21(gene name)|psi-mi:RAB21(display_short)|uniprotkb:KIAA0118(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055814.1|ensembl:ENSG00000080371(gene)|ensembl:ENST00000261263(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0005829"(cytosol)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:Q9UL25|rcsb pdb:1YZT|rcsb pdb:1YZU|rcsb pdb:1Z08|rcsb pdb:1Z0I|rcsb pdb:2OT3|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-29349N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xeTabB1AP4LZcYhU4u/vZwwETnA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00461	intact:EBI-1257113	intact:EBI-4401217|ensembl:ENSP00000417354	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:goli4_human(display_long)|uniprotkb:Golgi-localized phosphoprotein of 130 kDa(gene name synonym)|uniprotkb:GOLIM4(gene name)|psi-mi:GOLIM4(display_short)|uniprotkb:GIMPC(gene name synonym)|uniprotkb:GOLPH4(gene name synonym)|uniprotkb:GPP130(gene name synonym)|uniprotkb:Golgi integral membrane protein, cis(gene name synonym)|uniprotkb:Golgi phosphoprotein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055313.1|dip:DIP-61898N|ensembl:ENSG00000173905(gene)|ensembl:ENST00000470487(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032580"(Golgi cisterna membrane)|interpro:IPR042336|reactome:R-HSA-6811438	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IYYs/JH0wij/6jEmZwwPVc377pU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13596	intact:EBI-1257113	intact:EBI-2822329|uniprotkb:O60750|uniprotkb:A8K6T7|uniprotkb:A6NM19|uniprotkb:O60751|uniprotkb:H0Y2M5|uniprotkb:Q6ZRJ8|ensembl:ENSP00000453785	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx1_human(display_long)|uniprotkb:SNX1(gene name)|psi-mi:SNX1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003090.2|refseq:NP_683758.1|refseq:NP_001229862.1|ensembl:ENSG00000028528(gene)|ensembl:ENST00000559844(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028660|interpro:IPR034901|mint:Q13596|rcsb pdb:2I4K|rcsb pdb:4FZS|interpro:IPR036871|dip:DIP-398N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nFyxCtQ9gHndLbuCjBiwhyWE5do9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14617	intact:EBI-1257113	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7KZI7	intact:EBI-1257113	intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14828	intact:EBI-1257113	intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16186	intact:EBI-1257113	intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95379	intact:EBI-1257113	intact:EBI-1049336|uniprotkb:Q9P1Q1|uniprotkb:Q9UER5|uniprotkb:Q9UP47|uniprotkb:B3KMI2|uniprotkb:B3KMH1|ensembl:ENSP00000421848|ensembl:ENSP00000422245|uniprotkb:B7Z713	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tfip8_human(display_long)|uniprotkb:Head and neck tumor and metastasis-related protein(gene name synonym)|uniprotkb:TNF-induced protein GG2-1(gene name synonym)|uniprotkb:SCC-S2(gene name synonym)|uniprotkb:NF-kappa-B-inducible DED-containing protein(gene name synonym)|uniprotkb:MDC-3.13(gene name synonym)|uniprotkb:TNFAIP8(gene name)|psi-mi:TNFAIP8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001071122.1|refseq:NP_055165.2|refseq:NP_001273742.1|refseq:NP_001273743.1|refseq:NP_001273744.1|refseq:NP_001273746.1|ensembl:ENSG00000145779(gene)|ensembl:ENST00000503646(transcript)|ensembl:ENST00000504771(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR008477(Protein of unknown function DUF758)|interpro:IPR038355|mint:O95379|reactome:R-HSA-1483255	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kU/YcbWj8qTDg4s94mo4j41mT849606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75348	intact:EBI-1257113	intact:EBI-711802|intact:EBI-749668|uniprotkb:Q6IB33|ensembl:ENSP00000363162	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatg1_human(display_long)|uniprotkb:Vacuolar proton pump subunit G 1(gene name synonym)|uniprotkb:V-ATPase 13 kDa subunit 1(gene name synonym)|uniprotkb:Vacuolar proton pump subunit M16(gene name synonym)|uniprotkb:ATP6V1G1(gene name)|psi-mi:ATP6V1G1(display_short)|uniprotkb:ATP6G(gene name synonym)|uniprotkb:ATP6G1(gene name synonym)|uniprotkb:ATP6J(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004879.1|ensembl:ENSG00000136888(gene)|ensembl:ENST00000374050(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005124("Vacuolar (H+)-ATPase G subunit")|mint:O75348|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zsDN5vJcHlTb50mmly17mGztBAM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0C8	intact:EBI-1257113	intact:EBI-2620298|uniprotkb:B3KM39|ensembl:ENSP00000254654	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ilkap_human(display_long)|uniprotkb:ILKAP(gene name)|psi-mi:ILKAP(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_110395.1|ensembl:ENSG00000132323(gene)|ensembl:ENST00000254654(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q9H0C8	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iKH8FvITcNnqKYK8zIsijGhZllM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60664	intact:EBI-1257113	intact:EBI-725795|uniprotkb:Q53G77|uniprotkb:Q9BS03|uniprotkb:Q9UBD7|uniprotkb:Q9UP92|uniprotkb:A8K4Y9|intact:EBI-11103673|uniprotkb:K7EQF4|ensembl:ENSP00000221957	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:plin3_human(display_long)|uniprotkb:Cargo selection protein TIP47(gene name synonym)|uniprotkb:47 kDa mannose 6-phosphate receptor-binding protein(gene name synonym)|uniprotkb:Placental protein 17(gene name synonym)|uniprotkb:PLIN3(gene name)|psi-mi:PLIN3(display_short)|uniprotkb:TIP47(gene name synonym)|uniprotkb:M6PRBP1(gene name synonym)|uniprotkb:Mannose-6-phosphate receptor-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001157666.1|refseq:NP_001157661.1|refseq:NP_005808.3|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019915"(lipid storage)|go:"GO:0030133"(transport vesicle)|ensembl:ENSG00000105355(gene)|go:"GO:0045296"(cadherin binding)|interpro:IPR004279(Perilipin)|reactome:R-HSA-163560|reactome:R-HSA-6811440|reactome:R-HSA-9613354|ensembl:ENST00000221957(transcript)|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:U+skqZ/oQtQscaEvfdh+AVnCCKA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99720	intact:EBI-1257113	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61421	intact:EBI-1257113	intact:EBI-954063|ensembl:ENSP00000290949|uniprotkb:P12953|uniprotkb:Q02547	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:va0d1_human(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:32 kDa accessory protein(gene name synonym)|uniprotkb:ATP6V0D1(gene name)|psi-mi:ATP6V0D1(display_short)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VPATPD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000159720(gene)|ensembl:ENST00000290949(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P61421|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-381038|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016324"(apical plasma membrane)|refseq:NP_004682.2|dip:DIP-47435N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3a/yIxEF9LMwAZUR3npGQrw8xNo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14232	intact:EBI-1257113	intact:EBI-491065|uniprotkb:A6NLY9|uniprotkb:Q3SXP4|uniprotkb:B4DGX0|ensembl:ENSP00000416250	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ei2ba_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)|uniprotkb:EIF2B1(gene name)|psi-mi:EIF2B1(display_short)|uniprotkb:EIF2BA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001405.1|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:3ECS|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000111361(gene)|ensembl:ENST00000424014(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HAThUj88pwaLd6kmAlO5s1xtntM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51149	intact:EBI-1257113	intact:EBI-1056089|uniprotkb:A8K3V6|uniprotkb:Q9NWJ0|uniprotkb:Q9UPB0|ensembl:ENSP00000265062|ensembl:ENSP00000501618|ensembl:ENSP00000502000|ensembl:ENSP00000502088|ensembl:ENSP00000502486	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab7a_human(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004628.4|ensembl:ENSG00000075785(gene)|ensembl:ENST00000265062(transcript)|ensembl:ENST00000674589(transcript)|ensembl:ENST00000675342(transcript)|ensembl:ENST00000675497(transcript)|ensembl:ENST00000676214(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1902586"(obsolete multi-organism intercellular transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51149|rcsb pdb:1T91|rcsb pdb:1YHN|rcsb pdb:6IYB|rcsb pdb:6WCW|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9636383|reactome:R-HSA-9636569|rcsb pdb:3LAW|dip:DIP-39879N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0B6	intact:EBI-1257113	intact:EBI-726994|ensembl:ENSP00000314837|ensembl:ENSP00000377631|ensembl:ENSP00000399403|uniprotkb:Q9H9C8|uniprotkb:Q9HA20|uniprotkb:B2RDY4|uniprotkb:A8MXL7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc2_human(display_long)|uniprotkb:KLC2(gene name)|psi-mi:KLC2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000174996(gene)|ensembl:ENST00000316924(transcript)|ensembl:ENST00000394067(transcript)|ensembl:ENST00000417856(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0016938"(kinesin I complex)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045296"(cadherin binding)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q9H0B6|rcsb pdb:3CEQ|rcsb pdb:3EDT|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_001128246.1|refseq:NP_001128247.1|refseq:NP_001128248.1|refseq:NP_073733.1|refseq:NP_001305663.1|refseq:XP_005274240.1|dip:DIP-40381N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VjzT5tI182sjUbhjxC1bK9GSMHo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5S2	intact:EBI-1257113	intact:EBI-1043430|uniprotkb:Q2L7A5|uniprotkb:Q86TJ1|uniprotkb:Q9ULU5|ensembl:ENSP00000355237|uniprotkb:A9JR72	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mrckb_human(display_long)|uniprotkb:CDC42-binding protein kinase beta(gene name synonym)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase beta(gene name synonym)|uniprotkb:DMPK-like beta(gene name synonym)|uniprotkb:CDC42BPB(gene name)|psi-mi:CDC42BPB(display_short)|uniprotkb:KIAA1124(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSG00000198752(gene)|ensembl:ENST00000361246(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR031597|interpro:IPR033232|interpro:IPR042718|rcsb pdb:3QFV|rcsb pdb:3TKU|rcsb pdb:4UAK|rcsb pdb:4UAL|rcsb pdb:5OTE|rcsb pdb:5OTF|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|refseq:NP_006026.3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FaheT9htZ/NtYfTKvNDcLqNtQiQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P20073	intact:EBI-1257113	intact:EBI-2338704|uniprotkb:Q5F2H3|uniprotkb:Q5T0M6|uniprotkb:Q5T0M7|intact:EBI-28973842|ensembl:ENSP00000362010	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa7_human(display_long)|uniprotkb:ANXA7(gene name)|psi-mi:ANXA7(display_short)|uniprotkb:ANX7(gene name synonym)|uniprotkb:SNX(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Synexin(gene name synonym)|uniprotkb:OK/SW-cl.95(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000362010|ensembl:ENST00000372921|ensembl:ENSP00000362012|refseq:NP_001147.1|refseq:NP_004025.1|refseq:XP_016871651.1|refseq:XP_016871652.1|ensembl:ENSG00000138279(gene)|ensembl:ENST00000372919(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ad3I49rhRoZ0hG8ruDgSQWocVuw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UMY4	intact:EBI-1257113	intact:EBI-1752602|uniprotkb:Q8WUG9|ensembl:ENSP00000363392|ensembl:ENSP00000481314|uniprotkb:F8W8K5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx12_human(display_long)|uniprotkb:SNX12(gene name)|psi-mi:SNX12(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001243117.1|refseq:NP_001243114.1|refseq:NP_037478.2|ensembl:ENSG00000147164(gene)|ensembl:ENST00000374274(transcript)|ensembl:ENST00000622277(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030904"(retromer complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|rcsb pdb:2CSK	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ObeH0uH+d+BSI0bhoKXDrIte/nY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q07866	intact:EBI-1257113	intact:EBI-721019|uniprotkb:F8VTM4|uniprotkb:Q7RTQ3|uniprotkb:Q86V77|uniprotkb:Q86V78|uniprotkb:Q86V79|uniprotkb:Q7RTM2|uniprotkb:Q7RTM3|uniprotkb:Q7RTM5|uniprotkb:Q7RTP9|uniprotkb:Q7RTQ5|uniprotkb:Q7RTQ6|uniprotkb:Q86SF5|uniprotkb:Q86TF5|uniprotkb:Q86V74|uniprotkb:Q86V75|uniprotkb:Q86V76|uniprotkb:Q96H62|uniprotkb:A6NF62|intact:EBI-28976313|ensembl:ENSP00000341154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc1_human(display_long)|uniprotkb:KLC1(gene name)|psi-mi:KLC1(display_short)|uniprotkb:KLC(gene name synonym)|uniprotkb:KNS2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001123579.1|refseq:NP_005543.2|refseq:NP_891553.2|ensembl:ENST00000452929|ensembl:ENSP00000414982|ensembl:ENST00000553286|ensembl:ENSP00000452487|ensembl:ENST00000246489|ensembl:ENSP00000246489|ensembl:ENST00000334553|ensembl:ENST00000554228|ensembl:ENSP00000450616|ensembl:ENST00000557450|ensembl:ENSP00000450648|ensembl:ENST00000634686|ensembl:ENSP00000488938|ensembl:ENSP00000334523|ensembl:ENST00000347839|ensembl:ENSP00000334618|ensembl:ENSP00000341154|ensembl:ENST00000389744|ensembl:ENSP00000374394|dip:DIP-40371N|ensembl:ENSG00000126214(gene)|ensembl:ENST00000348520(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035617"(stress granule disassembly)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q07866|rcsb pdb:3NF1|rcsb pdb:5OJ8|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|go:"GO:0030426"(growth cone)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:T7SJbB/PScRqj74O/NH4q1KU0YM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51151	intact:EBI-1257113	intact:EBI-4401353|uniprotkb:Q6ICN1|uniprotkb:A8K390|ensembl:ENSP00000420127|ensembl:ENSP00000480777	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab9a_human(display_long)|uniprotkb:RAB9A(gene name)|psi-mi:RAB9A(display_short)|uniprotkb:RAB9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016885453.1|refseq:NP_001182257.1|refseq:NP_004242.1|dip:DIP-46409N|ensembl:ENSG00000123595(gene)|ensembl:ENST00000464506(transcript)|ensembl:ENST00000618931(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0052405"|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041824|mint:P51151|rcsb pdb:1WMS|reactome:R-HSA-6811440|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9706019	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:x0BjgzGEj7mPNlt2CQLkHtqQzDQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P60953-2	intact:EBI-1257113	intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NZZ3	intact:EBI-1257113	intact:EBI-751303|uniprotkb:Q5VXW2|uniprotkb:Q96AV2|uniprotkb:Q9HB68|uniprotkb:Q9NYS4|uniprotkb:Q9Y323|uniprotkb:B4DIR6|uniprotkb:B2RD95|ensembl:ENSP00000223500	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chmp5_human(display_long)|uniprotkb:Chromatin-modifying protein 5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 60(gene name synonym)|uniprotkb:SNF7 domain-containing protein 2(gene name synonym)|uniprotkb:CHMP5(gene name)|psi-mi:CHMP5(display_short)|uniprotkb:C9orf83(gene name synonym)|uniprotkb:SNF7DC2(gene name synonym)|uniprotkb:CGI-34(orf name)|uniprotkb:HSPC177(orf name)|uniprotkb:PNAS-2(orf name)|uniprotkb:PNAS-114(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057494.3|refseq:NP_001182465.1|dip:DIP-50420N|ensembl:ENSG00000086065(gene)|ensembl:ENST00000223500(transcript)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0046755"(viral budding)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q9NZZ3|rcsb pdb:2LXM|rcsb pdb:3ULY|rcsb pdb:3UM0|rcsb pdb:3UM1|rcsb pdb:3UM2|rcsb pdb:4TXR|reactome:R-HSA-162588|reactome:R-HSA-917729	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VqeFh9Sg3XIfJuZBF59GgMgY53c9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NWS8	intact:EBI-1257113	intact:EBI-4401316|uniprotkb:A8K8H4|uniprotkb:Q0VDG6|uniprotkb:Q5SZ48|uniprotkb:Q5SZ83|uniprotkb:Q6NSC5|uniprotkb:Q96EN7|ensembl:ENSP00000412708|ensembl:ENSP00000507984	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rmnd1_human(display_long)|uniprotkb:RMND1(gene name)|psi-mi:RMND1(display_short)|uniprotkb:C6orf96(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060379.2|refseq:XP_005267097.1|refseq:NP_001258866.1|refseq:XP_016866477.1|ensembl:ENSG00000155906(gene)|ensembl:ENST00000444024(transcript)|ensembl:ENST00000683724(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006412"(translation)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR003734(Protein of unknown function DUF155)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yCKKEY1X6dSYbAiTBhOwnPkkxyk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H267	intact:EBI-1257113	intact:EBI-749072|uniprotkb:Q96K14|uniprotkb:Q9NRP6|uniprotkb:Q9NSF3|uniprotkb:B3KQF6|ensembl:ENSP00000327650	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp33b_human(display_long)|uniprotkb:VPS33B(gene name)|psi-mi:VPS33B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061138.3|refseq:NP_001276077.1|refseq:XP_011519750.1|refseq:NP_001276078.1|refseq:XP_005254944.1|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|interpro:IPR043155|mint:Q9H267|reactome:R-HSA-9636383|interpro:IPR027121|ensembl:ENSG00000184056(gene)|ensembl:ENST00000333371(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007032"(endosome organization)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030897"(HOPS complex)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032418"(lysosome localization)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0033263"(CORVET complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0070889"(platelet alpha granule organization)|interpro:IPR001619(Sec1-like protein)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:T2rUOt9qjfn8vCzySAKCCa3UC689606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49770	intact:EBI-1257113	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NUP9	intact:EBI-1257113	intact:EBI-1171517|ensembl:ENSP00000278193	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P56962	intact:EBI-1257113	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96T88	intact:EBI-1257113	intact:EBI-1548946|uniprotkb:Q8J022|uniprotkb:Q9H6S6|uniprotkb:Q9P115|uniprotkb:Q9P1U7|uniprotkb:A0JBR2|uniprotkb:A8K024|uniprotkb:B2RBA9|uniprotkb:Q2HIX7|ensembl:ENSP00000478348|ensembl:ENSP00000478601|ensembl:ENSP00000484739|ensembl:ENSP00000485604|ensembl:ENSP00000498698	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:uhrf1_human(display_long)|uniprotkb:UHRF1(gene name)|psi-mi:UHRF1(display_short)|uniprotkb:ICBP90(gene name synonym)|uniprotkb:NP95(gene name synonym)|uniprotkb:RNF106(gene name synonym)|uniprotkb:Ubiquitin-like PHD and RING finger domain-containing protein 1(gene name synonym)|uniprotkb:Ubiquitin-like-containing PHD and RING finger domains protein 1(gene name synonym)|uniprotkb:Inverted CCAAT box-binding protein of 90 kDa(gene name synonym)|uniprotkb:Transcription factor ICBP90(gene name synonym)|uniprotkb:Nuclear zinc finger protein Np95(gene name synonym)|uniprotkb:Nuclear protein 95(gene name synonym)|uniprotkb:RING finger protein 106(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UHRF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276979.1|refseq:NP_001276980.1|refseq:NP_001276981.1|refseq:NP_037414.3|refseq:NP_001041666.1|ensembl:ENSG00000276043(gene)|ensembl:ENST00000612630(transcript)|ensembl:ENST00000615884(transcript)|ensembl:ENST00000616255(transcript)|ensembl:ENST00000624301(transcript)|ensembl:ENST00000650932(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044729"(hemi-methylated DNA-binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR000626(Ubiquitin)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003105(SRA-YDG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015947(PUA-like)|interpro:IPR017907|interpro:IPR019787|interpro:IPR021991|interpro:IPR029071|interpro:IPR036987|mint:Q96T88|rcsb pdb:2FAZ|rcsb pdb:2L3R|rcsb pdb:2LGG|rcsb pdb:2LGK|rcsb pdb:2LGL|rcsb pdb:2PB7|rcsb pdb:3ASK|rcsb pdb:3ASL|rcsb pdb:3BI7|rcsb pdb:3CLZ|rcsb pdb:3DB3|rcsb pdb:3DB4|rcsb pdb:3DWH|rcsb pdb:3FL2|rcsb pdb:3SHB|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3SOX|rcsb pdb:3T6R|rcsb pdb:3ZVY|rcsb pdb:3ZVZ|rcsb pdb:4GY5|rcsb pdb:4QQD|rcsb pdb:5C6D|rcsb pdb:5IAY|rcsb pdb:5XPI|rcsb pdb:5YY9|rcsb pdb:5YYA|rcsb pdb:6B9M|rcsb pdb:6IIW|rcsb pdb:6VCS|rcsb pdb:6VED|rcsb pdb:6VYJ|rcsb pdb:6W92|reactome:R-HSA-5334118|interpro:IPR001841(Zinc finger, RING-type)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AbWLjSoRl82HTcjZlG4DRavDdGc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15057	intact:EBI-1257113	intact:EBI-4401196|uniprotkb:A8K2V4|uniprotkb:Q8N5Z8|uniprotkb:Q9UQR3|ensembl:ENSP00000324287	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:acap2_human(display_long)|uniprotkb:ACAP2(gene name)|psi-mi:ACAP2(display_short)|uniprotkb:CENTB2(gene name synonym)|uniprotkb:KIAA0041(gene name synonym)|uniprotkb:Centaurin-beta-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036419.3|ensembl:ENSG00000114331(gene)|ensembl:ENST00000326793(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030029"(actin filament-based process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0046872"(metal ion binding)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|rcsb pdb:6IF3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VHSpT12NSofZq3m02WlQNqj1IAQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51809	intact:EBI-1257113	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27797	intact:EBI-1257113	intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UI10	intact:EBI-1257113	intact:EBI-2340132|uniprotkb:Q53RY7|uniprotkb:Q9UIQ9|uniprotkb:Q9UJ95|uniprotkb:Q5BJF4|uniprotkb:Q9UBG4|uniprotkb:Q9BUV9|ensembl:ENSP00000233552	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ei2bd_human(display_long)|uniprotkb:EIF2B4(gene name)|psi-mi:EIF2B4(display_short)|uniprotkb:EIF2BD(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001029288.1|refseq:NP_056451.3|refseq:NP_751945.2|refseq:NP_001305894.1|refseq:NP_001305895.1|refseq:NP_001305896.1|refseq:NP_001305897.1|ensembl:ENSG00000115211(gene)|ensembl:ENST00000347454(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006417"(regulation of translation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|mint:Q9UI10|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZCU4mIO5zkmBajIvBRe3b2PZINw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P253	intact:EBI-1257113	intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13409	intact:EBI-1257113	intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H1C4	intact:EBI-1257113	intact:EBI-4401271|uniprotkb:O95764|uniprotkb:Q569H6|uniprotkb:Q710D4|ensembl:ENSP00000227471	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:un93b_human(display_long)|uniprotkb:UNC93B1(gene name)|psi-mi:UNC93B1(display_short)|uniprotkb:UNC93(gene name synonym)|uniprotkb:UNC93B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_112192.2|ensembl:ENSG00000110057(gene)|ensembl:ENST00000227471(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR010291(Protein of unknown function DUF895, eukaryotic)|interpro:IPR043268|rcsb pdb:7C76|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-5602415	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KG5h76GZKYHGsRSa+VoDFhbJkOc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52824	intact:EBI-1257113	intact:EBI-4401238|uniprotkb:Q6P3W4|ensembl:ENSP00000273814	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dgkq_human(display_long)|uniprotkb:DGKQ(gene name)|psi-mi:DGKQ(display_short)|uniprotkb:DAGK4(gene name synonym)|uniprotkb:Diglyceride kinase theta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001338.2|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051591"(response to cAMP)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:2000064"(regulation of cortisol biosynthetic process)|go:"GO:2000182"(regulation of progesterone biosynthetic process)|interpro:IPR000159(Ras-association)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR029071|interpro:IPR037607|reactome:R-HSA-114508|ensembl:ENSG00000145214(gene)|ensembl:ENST00000273814(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EIx+aVfl0V0AE3dpJxWzFlaRMf89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75351	intact:EBI-1257113	intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BBEuP035ynUSYZcCp76bTduLz589606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q53H12	intact:EBI-1257113	intact:EBI-2269837|uniprotkb:Q75KN1|uniprotkb:Q96GC3|uniprotkb:Q9NP48|ensembl:ENSP00000496789|ensembl:ENSP00000497280|ensembl:ENSP00000498112|ensembl:ENSP00000458417	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:agk_human(display_long)|uniprotkb:AGK(gene name)|psi-mi:AGK(display_short)|uniprotkb:MULK(gene name synonym)|uniprotkb:Multiple substrate lipid kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514699.1|refseq:NP_060708.1|ensembl:ENSG00000006530(gene)|ensembl:ENST00000575872(transcript)|ensembl:ENST00000648068(transcript)|ensembl:ENST00000649286(transcript)|ensembl:ENST00000650547(transcript)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0001729"(ceramide kinase activity)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042721"(TIM22 mitochondrial import inner membrane insertion complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0047620"(acylglycerol kinase activity)|go:"GO:0102773"(dihydroceramide kinase activity)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|go:"GO:0005743"(mitochondrial inner membrane)|ensembl:ENSG00000262327(gene)|rcsb pdb:7CGP|reactome:R-HSA-1483206|reactome:R-HSA-6802952|mint:Q53H12	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aUz/aYnkviiUE/ijNEddfOQmjZQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NP72	intact:EBI-1257113	intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13510	intact:EBI-1257113	intact:EBI-714581|uniprotkb:Q6W898|uniprotkb:E9PDS0|uniprotkb:Q96AS2|ensembl:ENSP00000490272|ensembl:ENSP00000490506	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:asah1_human(display_long)|uniprotkb:Acylsphingosine deacylase(gene name synonym)|uniprotkb:N-acylsphingosine amidohydrolase(gene name synonym)|uniprotkb:Putative 32 kDa heart protein(gene name synonym)|uniprotkb:HSD33(orf name)|uniprotkb:ASAH1(gene name)|psi-mi:ASAH1(display_short)|uniprotkb:ASAH(gene name synonym)|uniprotkb:HSD-33(orf name)|uniprotkb:N-acylethanolamine hydrolase ASAH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001120977.1|refseq:NP_004306.3|refseq:NP_808592.2|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046514"(ceramide catabolic process)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0062098"(regulation of programmed necrotic cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0102121"(ceramidase activity)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR016699(Acid ceramidase-like)|interpro:IPR029130|interpro:IPR029132|mint:Q13510|rcsb pdb:5U7Z|rcsb pdb:6MHM|reactome:R-HSA-1660662|go:"GO:0017064"(fatty acid amide hydrolase activity)|ensembl:ENSG00000104763(gene)|ensembl:ENST00000635998(transcript)|ensembl:ENST00000637790(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017040"(N-acylsphingosine amidohydrolase activity)|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nVtUQ1YDfManbzaGXOGLSO8qzks9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UI12	intact:EBI-1257113	intact:EBI-724719|uniprotkb:Q6PK44|uniprotkb:Q9H3E3|uniprotkb:Q9Y300|uniprotkb:B3KMR0|ensembl:ENSP00000352522|ensembl:ENSP00000379995	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vath_human(display_long)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 50/57 kDa subunits(gene name synonym)|uniprotkb:Vacuolar proton pump subunit SFD(gene name synonym)|uniprotkb:Protein VMA13 homolog(gene name synonym)|uniprotkb:Nef-binding protein 1(gene name synonym)|uniprotkb:ATP6V1H(gene name)|psi-mi:ATP6V1H(display_short)|uniprotkb:CGI-11(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057025.2|refseq:NP_998784.1|refseq:NP_998785.1|ensembl:ENSG00000047249(gene)|ensembl:ENST00000359530(transcript)|ensembl:ENST00000396774(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|mint:Q9UI12|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-167590|reactome:R-HSA-182218|reactome:R-HSA-917977|reactome:R-HSA-9636467|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:XP_006716518.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:n2fyA8m4qnlSmS3R1xBBE3RRV9A9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BJ8	intact:EBI-1257113	intact:EBI-4400939|uniprotkb:B4DV86|uniprotkb:Q9H8A5|ensembl:ENSP00000377566	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:elmo3_human(display_long)|uniprotkb:ELMO3(gene name)|psi-mi:ELMO3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_078988.2|ensembl:ENSG00000102890(gene)|ensembl:ENST00000393997(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719|go:"GO:0048870"(cell motility)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aZHFb561Oh1Mf14Qe/uuXDDtEp89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P289	intact:EBI-1257113	intact:EBI-618239|intact:EBI-1774248|uniprotkb:Q8NC04|uniprotkb:Q9BXC3|ensembl:ENSP00000377867|uniprotkb:Q9BXC4|uniprotkb:Q3ZB77|uniprotkb:B2RAU2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stk26_human(display_long)|uniprotkb:STK26(gene name)|psi-mi:STK26(display_short)|uniprotkb:MASK(gene name synonym)|uniprotkb:MST3 and SOK1-related kinase(gene name synonym)|uniprotkb:MST4(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase MASK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134602(gene)|ensembl:ENST00000394334(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035056|rcsb pdb:3GGF|rcsb pdb:3W8I|rcsb pdb:4FZA|rcsb pdb:4FZD|rcsb pdb:4FZF|rcsb pdb:4GEH|rcsb pdb:5XY9|rcsb pdb:5YF4|rcsb pdb:7B36|reactome:R-HSA-111465|interpro:IPR000719(Protein kinase, core)|refseq:NP_001035917.1|refseq:NP_001035918.1|refseq:NP_057626.2|dip:DIP-34049N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:V6BRp2h2O0RdLI1gRobMJKh28cA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27824	intact:EBI-1257113	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62873	intact:EBI-1257113	intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14735	intact:EBI-1257113	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13576	intact:EBI-1257113	intact:EBI-357571|uniprotkb:J3KR91|uniprotkb:A8K4V1|uniprotkb:B7Z8A4|ensembl:ENSP00000274364	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:iqga2_human(display_long)|uniprotkb:IQGAP2(gene name)|psi-mi:IQGAP2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001272389.1|refseq:NP_001272390.1|refseq:NP_001272391.1|refseq:NP_006624.2|ensembl:ENSG00000145703(gene)|ensembl:ENST00000274364(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR036872|mint:Q13576|rcsb pdb:3IEZ|rcsb pdb:4EZA|rcsb pdb:5CJP|reactome:R-HSA-5626467|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013408|dip:DIP-27542N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gmxbOFcisiWIsQrHFQCoI5y49T09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52735	intact:EBI-1257113	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61026	intact:EBI-1257113	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61020	intact:EBI-1257113	intact:EBI-399401|uniprotkb:P35239|uniprotkb:P35277|uniprotkb:Q6PIK9|uniprotkb:Q86TH0|uniprotkb:Q8IXL2|uniprotkb:A8K982|uniprotkb:B4DKD7|ensembl:ENSP00000353444|ensembl:ENSP00000450168	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab5b_human(display_long)|uniprotkb:RAB5B(gene name)|psi-mi:RAB5B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002859.1|refseq:NP_001238965.1|refseq:XP_005269108.1|refseq:XP_005269109.1|refseq:NP_001238966.1|ensembl:ENSG00000111540(gene)|ensembl:ENST00000360299(transcript)|ensembl:ENST00000553116(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2HEI|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jm+x3SYDL+i+/BrDFnp44kxlHUM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86VI3	intact:EBI-1257113	intact:EBI-1237354|uniprotkb:Q5T3H8|ensembl:ENSP00000354451	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:iqga3_human(display_long)|uniprotkb:IQGAP3(gene name)|psi-mi:IQGAP3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_839943.2|ensembl:ENSP00000354451|ensembl:ENSG00000183856(gene)|ensembl:ENST00000361170(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051015"(actin filament binding)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070856"(myosin VI light chain binding)|go:"GO:0071310"(cellular response to organic substance)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|mint:Q86VI3|rcsb pdb:3ISU|reactome:R-HSA-5626467|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|interpro:IPR036872	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:5lIYEC2lJihenWFio0Q+1W9EINI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P36404	intact:EBI-1257113	intact:EBI-752365|uniprotkb:Q9BUK8|uniprotkb:G3V184|ensembl:ENSP00000246747|ensembl:ENSP00000436021	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl2_human(display_long)|uniprotkb:ARL2(gene name)|psi-mi:ARL2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001186674.1|refseq:NP_001658.2|dip:DIP-47535N|ensembl:ENSG00000213465(gene)|ensembl:ENST00000246747(transcript)|ensembl:ENST00000529384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:P36404|rcsb pdb:3DOE|rcsb pdb:3DOF|reactome:R-HSA-389977|reactome:R-HSA-83936|reactome:R-HSA-9648002	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ArQxx65a8vITU2O0Kr0Qo0hqiqU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75477	intact:EBI-1257113	intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63010	intact:EBI-1257113	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P12429	intact:EBI-1257113	intact:EBI-712677|uniprotkb:Q6LET2|ensembl:ENSP00000264908|uniprotkb:B2R9W6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa3_human(display_long)|uniprotkb:Annexin-3(gene name synonym)|uniprotkb:Annexin III(gene name synonym)|uniprotkb:Lipocortin III(gene name synonym)|uniprotkb:Placental anticoagulant protein III(gene name synonym)|uniprotkb:35-alpha calcimedin(gene name synonym)|uniprotkb:Inositol 1,2-cyclic phosphate 2-phosphohydrolase(gene name synonym)|uniprotkb:ANXA3(gene name)|psi-mi:ANXA3(display_short)|uniprotkb:ANX3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000138772(gene)|ensembl:ENST00000264908(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042581"(specific granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070848"(response to growth factor)|interpro:IPR001464(Annexin)|interpro:IPR002390(Annexin, type III)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|rcsb pdb:1AII|rcsb pdb:1AXN|refseq:NP_005130.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ofvDhzyqwVfbx59luw/Vdhuu6Xc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62820	intact:EBI-1257113	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P48739	intact:EBI-1257113	intact:EBI-1047143|uniprotkb:Q8N5W1|uniprotkb:B7Z7Q0|uniprotkb:B3KYB8|ensembl:ENSP00000334738	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pipnb_human(display_long)|uniprotkb:PITPNB(gene name)|psi-mi:PITPNB(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036531.1|refseq:NP_001271206.1|refseq:NP_001271207.1|ensembl:ENSG00000180957(gene)|ensembl:ENST00000335272(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006997"(nucleus organization)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0015914"(phospholipid transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0140338"(sphingomyelin transfer activity)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR023393|reactome:R-HSA-1483196	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:sfXjQFess0PnkuuxgTJsF/ANRFk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50995	intact:EBI-1257113	intact:EBI-715243|ensembl:ENSP00000361305|ensembl:ENSP00000398610|ensembl:ENSP00000404412|uniprotkb:B4DVE7|intact:EBI-10981770	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anx11_human(display_long)|uniprotkb:Annexin-11(gene name synonym)|uniprotkb:Annexin XI(gene name synonym)|uniprotkb:Calcyclin-associated annexin 50(gene name synonym)|uniprotkb:56 kDa autoantigen(gene name synonym)|uniprotkb:ANXA11(gene name)|psi-mi:ANXA11(display_short)|uniprotkb:ANX11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000122359(gene)|ensembl:ENST00000372231(transcript)|ensembl:ENST00000422982(transcript)|ensembl:ENST00000438331(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030496"(midbody)|go:"GO:0032506"(cytokinetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR008157(Annexin, type XI, N-terminal)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|refseq:NP_001148.1|refseq:NP_665875.1|refseq:NP_665876.1|refseq:XP_011538038.1|refseq:NP_001265336.1|refseq:NP_001265337.1|refseq:NP_001265338.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6j7B4/J0DI0LZADQ5klJQoYf7289606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5JWF2	intact:EBI-1257113	intact:EBI-4400880|uniprotkb:A2A2S3|uniprotkb:E1P5G3|uniprotkb:O75684|uniprotkb:O75685|uniprotkb:Q5JW67|uniprotkb:Q5JWF1|uniprotkb:Q9NY42|ensembl:ENSP00000360141	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gnas1_human(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:Extra large alphas protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001296812.1|refseq:NP_536350.2|refseq:XP_016883302.1|ensembl:ENSG00000087460(gene)|ensembl:ENST00000371100(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q5JWF2|reactome:R-HSA-163359|reactome:R-HSA-164378|reactome:R-HSA-381676|reactome:R-HSA-392851|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-432040|reactome:R-HSA-5610787|reactome:R-HSA-9660821	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UmsO2DSEM3LmGMPwxSdkmlrKMLc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H9H4	intact:EBI-1257113	intact:EBI-4400866|intact:EBI-28975719|ensembl:ENSP00000267202	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp37b_human(display_long)|uniprotkb:VPS37B(gene name)|psi-mi:VPS37B(display_short)|uniprotkb:ESCRT-I complex subunit VPS37B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000267202|refseq:NP_078943.1|ensembl:ENSG00000139722(gene)|ensembl:ENST00000267202(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR029012|interpro:IPR037202|mint:Q9H9H4|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dj398+zsegXf+gk9OiSeZAVlmqk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P21281	intact:EBI-1257113	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NP79	intact:EBI-1257113	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60343	intact:EBI-1257113	intact:EBI-522028|uniprotkb:A7E2X8|uniprotkb:B4DU25|uniprotkb:B4E235|uniprotkb:B6ETN8|uniprotkb:B6ETN9|uniprotkb:Q68D14|uniprotkb:Q5W0B9|ensembl:ENSP00000366863	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbcd4_human(display_long)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:TBC1D4(gene name)|psi-mi:TBC1D4(display_short)|uniprotkb:KIAA0603(gene name synonym)|uniprotkb:AS160(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055647.2|ensembl:ENSG00000136111(gene)|ensembl:ENST00000377636(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|refseq:NP_001273587.1|refseq:NP_001273588.1|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:O60343|rcsb pdb:3QYB|rcsb pdb:7NIX|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AfptaRNss/0wnCrivoxs2PgxNOM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16181	intact:EBI-1257113	intact:EBI-2009373|uniprotkb:Q52M76|uniprotkb:Q6NX50|ensembl:ENSP00000381992	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept7_human(display_long)|uniprotkb:SEPTIN7(gene name)|psi-mi:SEPTIN7(display_short)|uniprotkb:CDC10(gene name synonym)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:SEPT7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001779.3|dip:DIP-47093N|ensembl:ENSG00000122545(gene)|ensembl:ENST00000399034(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR008115(Septin 7)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:2QAG|rcsb pdb:3T5D|rcsb pdb:3TW4|rcsb pdb:6N0B|rcsb pdb:6N12|rcsb pdb:6UQQ|reactome:R-HSA-5687128	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CweIjGLXC7eubvKR7vkkihEkcHg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14683	intact:EBI-1257113	intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6PIF6	intact:EBI-1257113	intact:EBI-4400912|uniprotkb:Q14786|uniprotkb:Q8TEE1|ensembl:ENSP00000415090	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:myo7b_human(display_long)|uniprotkb:MYO7B(gene name)|psi-mi:MYO7B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001073996.1|ensembl:ENSG00000169994(gene)|ensembl:ENST00000428314(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007015"(actin filament organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030154"(cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0090651"(apical cytoplasm)|go:"GO:1904970"(brush border assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|interpro:IPR038185|interpro:IPR041793|interpro:IPR041794|rcsb pdb:5MV7|rcsb pdb:5MV8|rcsb pdb:5XBF|interpro:IPR000299(Band 4.1, N-terminal)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zP1FXwmI8b1AoQI94olXnf395To9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NHP6	intact:EBI-1257113	intact:EBI-2812848|uniprotkb:Q8NA83|uniprotkb:Q8N3H2|ensembl:ENSP00000369860	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mspd2_human(display_long)|uniprotkb:MOSPD2(gene name)|psi-mi:MOSPD2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001170946.1|refseq:NP_689794.1|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0140284"(endoplasmic reticulum-endosome membrane contact site)|interpro:IPR000535(Major sperm protein)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036273|interpro:IPR036865|mint:Q8NHP6|rcsb pdb:6TQS|rcsb pdb:6TQT|rcsb pdb:6TQU|reactome:R-HSA-6798695|reactome:R-HSA-9013405|ensembl:ENSG00000130150(gene)|ensembl:ENST00000380492(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044232"(organelle membrane contact site)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WEdwMYKpu1uQll5NXnMm4P51R4E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52306	intact:EBI-1257113	intact:EBI-746389|uniprotkb:Q9BUW9|ensembl:ENSP00000386153|intact:EBI-3184182|uniprotkb:G5E9P9|uniprotkb:Q499L7|uniprotkb:Q4KMV2|uniprotkb:Q9BUX6|uniprotkb:Q9NYM2|uniprotkb:Q9NZA8|intact:EBI-4397492|uniprotkb:E9PH06|uniprotkb:Q4QQI8|intact:EBI-11106358	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gds1_human(display_long)|uniprotkb:RAP1GDS1(gene name)|psi-mi:RAP1GDS1(display_short)|uniprotkb:Exchange factor smgGDS(gene name synonym)|uniprotkb:SMG GDS protein(gene name synonym)|uniprotkb:SMG P21 stimulatory GDP/GTP exchange protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_066982.3|refseq:NP_001093898.1|ensembl:ENSG00000138698(gene)|ensembl:ENST00000408927(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040144|rcsb pdb:5XGC|rcsb pdb:5ZHX|reactome:R-HSA-9013419|reactome:R-HSA-9013425|refseq:NP_001093896.1|refseq:NP_001093897.1|refseq:NP_001093899.1|refseq:NP_001093900.1|dip:DIP-61080N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CBqwhiENmk65uN7XyiVVYZ+W6R09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62826	intact:EBI-1257113	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60645	intact:EBI-1257113	intact:EBI-1052278|uniprotkb:Q8TEN6|uniprotkb:Q8WUW0|uniprotkb:Q96DI4|uniprotkb:Q6P2E8|ensembl:ENSP00000323377|ensembl:ENSP00000425587|intact:EBI-11944037	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc3_human(display_long)|uniprotkb:Exocyst complex component Sec6(gene name synonym)|uniprotkb:EXOC3(gene name)|psi-mi:EXOC3(display_short)|uniprotkb:SEC6(gene name synonym)|uniprotkb:SEC6L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016864492.1|refseq:XP_016864493.1|ensembl:ENSG00000180104(gene)|ensembl:ENST00000315013(transcript)|ensembl:ENST00000512944(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000149"(SNARE binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051601"(exocyst localization)|interpro:IPR010326(Exocyst complex component Sec6)|interpro:IPR042532|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0030426"(growth cone)|refseq:NP_009208.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:7nhIGGYkkrej3iW0UKDqP5BwUz09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75436	intact:EBI-1257113	intact:EBI-1043891|uniprotkb:Q8TBH4|uniprotkb:Q9H982|ensembl:ENSP00000263559|ensembl:ENSP00000362480|uniprotkb:B2RDD3|uniprotkb:A8MZ56	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp26a_human(display_long)|uniprotkb:VPS26A(gene name)|psi-mi:VPS26A(display_short)|uniprotkb:VPS26(gene name synonym)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000122958(gene)|ensembl:ENST00000263559(transcript)|ensembl:ENST00000373382(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:O75436|rcsb pdb:2FAU|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|reactome:R-HSA-3238698|rcsb pdb:7BLO|refseq:NP_001030337.1|refseq:NP_004887.2|refseq:NP_001305875.1|dip:DIP-29075N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:n0uOd+2HQmRW7koIy678uP0d3+o9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15907	intact:EBI-1257113	intact:EBI-722234|uniprotkb:Q2YDT2|uniprotkb:Q8NI07|uniprotkb:B2R7I4|uniprotkb:D6W671|uniprotkb:A5YM50|uniprotkb:Q5U0I1|uniprotkb:Q6FHR0|uniprotkb:Q6FI42|uniprotkb:B4DMK0|ensembl:ENSP00000333547	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rb11b_human(display_long)|uniprotkb:GTP-binding protein YPT3(gene name synonym)|uniprotkb:RAB11B(gene name)|psi-mi:RAB11B(display_short)|uniprotkb:YPT3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004209.2|dip:DIP-50898N|ensembl:ENSG00000185236(gene)|ensembl:ENST00000328024(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q15907|rcsb pdb:2F9L|rcsb pdb:2F9M|rcsb pdb:4OJK|reactome:R-HSA-8854214|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+fsu7NPmd5fgoe0TE67IcISlscA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTJ5	intact:EBI-1257113	intact:EBI-3917235|uniprotkb:B4DK71|uniprotkb:Q7LA14|uniprotkb:A8K527|uniprotkb:Q96AX7|uniprotkb:Q9NQ46|uniprotkb:Q9NQ57|uniprotkb:O94935|uniprotkb:Q7LA22|ensembl:ENSP00000373713|ensembl:ENSP00000500361	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sac1_human(display_long)|uniprotkb:SACM1L(gene name)|psi-mi:SACM1L(display_short)|uniprotkb:KIAA0851(gene name synonym)|uniprotkb:Suppressor of actin mutations 1-like protein(gene name synonym)|uniprotkb:Phosphatidylinositol-4-phosphate phosphatase(gene name synonym)|uniprotkb:SAC1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011531802.1|refseq:NP_054735.3|refseq:NP_001306001.1|refseq:NP_001306002.1|ensembl:ENSG00000211456(gene)|ensembl:ENST00000389061(transcript)|ensembl:ENST00000672477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034593"(phosphatidylinositol bisphosphate phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR002013(Synaptojanin, N-terminal)|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016791"(phosphatase activity)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aaI+D/4SJcwZxWqoxDJ81dA60nU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P2W9	intact:EBI-1257113	intact:EBI-725334|uniprotkb:Q596L3|uniprotkb:Q5TZP5|ensembl:ENSP00000305810	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx18_human(display_long)|uniprotkb:Cell growth-inhibiting gene 9 protein(gene name synonym)|uniprotkb:STX18(gene name)|psi-mi:STX18(display_short)|uniprotkb:GIG9(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_058626.1|refseq:NP_001333211.1|refseq:NP_001333210.1|refseq:NP_001333229.1|ensembl:ENSG00000168818(gene)|ensembl:ENST00000306200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1902117"(positive regulation of organelle assembly)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR019529|mint:Q9P2W9|reactome:R-HSA-6811434|dip:DIP-37617N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QpvkckDM1D5Jaty6AmK3vEwRZts9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UN37	intact:EBI-1257113	intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UK41	intact:EBI-1257113	intact:EBI-727424|uniprotkb:Q86VK0|ensembl:ENSP00000292510|ensembl:ENSP00000434064|ensembl:ENSP00000496519|ensembl:ENSP00000496693	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps28_human(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057292.1|refseq:NP_898880.1|ensembl:ENSG00000160948(gene)|ensembl:ENSG00000285339(gene)|ensembl:ENST00000292510(transcript)|ensembl:ENST00000526054(transcript)|ensembl:ENST00000642867(transcript)|ensembl:ENST00000643186(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|mint:Q9UK41|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GUcc7bRf1LaLklAYVLEHRSihPjA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61006	intact:EBI-1257113	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61019	intact:EBI-1257113	intact:EBI-752037|uniprotkb:P08886|uniprotkb:B2R5W8|uniprotkb:B4DMQ5|ensembl:ENSP00000262646	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab2a_human(display_long)|uniprotkb:RAB2A(gene name)|psi-mi:RAB2A(display_short)|uniprotkb:RAB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002856.1|refseq:NP_001229573.1|dip:DIP-316N|ensembl:ENSG00000104388(gene)|ensembl:ENST00000262646(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1Z0A|reactome:R-HSA-162658|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MyG011KOkAtsvE2hU/fs21CEe/M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99439	intact:EBI-1257113	intact:EBI-2961712|ensembl:ENSP00000263097|uniprotkb:Q92578|uniprotkb:A5D8U8|uniprotkb:D6W5X9|uniprotkb:A6NFI4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cnn2_human(display_long)|uniprotkb:CNN2(gene name)|psi-mi:CNN2(display_short)|uniprotkb:Calponin H2, smooth muscle(gene name synonym)|uniprotkb:Neutral calponin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000064666(gene)|ensembl:ENST00000263097(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045296"(cadherin binding)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001997(Calponin)|interpro:IPR003096(SM22/calponin)|interpro:IPR029974|interpro:IPR036872|rcsb pdb:1WYN|reactome:R-HSA-6798695|reactome:R-HSA-8950505|refseq:NP_004359.1|refseq:NP_958434.1|refseq:NP_001290428.1|refseq:NP_001290430.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:64KRSh4MEocrTZ8EuTz9ni8ahhc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6W5	intact:EBI-1257113	intact:EBI-4290615|uniprotkb:O60794|uniprotkb:Q9UDY7|intact:EBI-28973998|ensembl:ENSP00000483313|uniprotkb:B4DZN0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wasf2_human(display_long)|uniprotkb:WASF2(gene name)|psi-mi:WASF2(display_short)|uniprotkb:WAVE2(gene name synonym)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_008921.1|ensembl:ENST00000536657|ensembl:ENSP00000439883|ensembl:ENSP00000483313|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q9Y6W5|rcsb pdb:2A40|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|ensembl:ENSG00000158195(gene)|ensembl:ENST00000618852(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|refseq:NP_001188333.1|dip:DIP-41817N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lRPT4syjPdKz2JoqWQQm3xw4hWc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WU76	intact:EBI-1257113	intact:EBI-2561361|ensembl:ENSP00000384182|uniprotkb:Q8N5F3|uniprotkb:Q96ED3|uniprotkb:Q8N8H0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scfd2_human(display_long)|uniprotkb:SCFD2(gene name)|psi-mi:SCFD2(display_short)|uniprotkb:STXBP1L1(gene name synonym)|uniprotkb:Syntaxin-binding protein 1-like 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000184178(gene)|ensembl:ENST00000401642(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|refseq:NP_689753.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:TaNn58iCMGPAhs6k76eLY0BuGKM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P22307	intact:EBI-1257113	intact:EBI-1050999|uniprotkb:Q15432|uniprotkb:Q16622|uniprotkb:Q99430|uniprotkb:Q5VVZ1|uniprotkb:D3DQ37|ensembl:ENSP00000360569|uniprotkb:Q6NXF4|uniprotkb:B4DHP6|uniprotkb:A6NM69|uniprotkb:B4DGJ9|uniprotkb:C9JC79|uniprotkb:E1B6W5|uniprotkb:F2Z3J1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scp2_human(display_long)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:SCPX(gene name synonym)|uniprotkb:SCP2(gene name)|psi-mi:SCP2(display_short)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001180528.1|refseq:NP_001007100.1|refseq:NP_001007101.1|refseq:NP_001007251.1|refseq:NP_002970.2|ensembl:ENSG00000116171(gene)|ensembl:ENST00000371514(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P22307|rcsb pdb:1QND|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-9033241|reactome:R-HSA-9033500|rcsb pdb:2C0L|refseq:XP_016857535.1|refseq:NP_001007099.1|refseq:NP_001180546.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Vwnu7RuD/2qhcH55Fl9v2TMErtc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P36543	intact:EBI-1257113	intact:EBI-348639|ensembl:ENSP00000253413|uniprotkb:A8MUE4|uniprotkb:A8MUN4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vate1_human(display_long)|uniprotkb:ATP6V1E1(gene name)|psi-mi:ATP6V1E1(display_short)|uniprotkb:ATP6E(gene name synonym)|uniprotkb:Vacuolar proton pump subunit E 1(gene name synonym)|uniprotkb:V-ATPase 31 kDa subunit(gene name synonym)|uniprotkb:ATP6E2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001687.1|ensembl:ENSG00000131100(gene)|ensembl:ENST00000253413(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002842(ATPase, V1/A1 complex, subunit E)|interpro:IPR038495|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:NP_001034455.1|refseq:NP_001034456.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tTf7Cl6DOsN3USZrmZijWhmhEhg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43237	intact:EBI-1257113	intact:EBI-715294|uniprotkb:Q8TAT3|uniprotkb:A8K6V1|uniprotkb:B4DZP4|ensembl:ENSP00000258198	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dc1l2_human(display_long)|uniprotkb:Dynein light intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:LIC53/55(gene name synonym)|uniprotkb:DYNC1LI2(gene name)|psi-mi:DYNC1LI2(display_short)|uniprotkb:LIC2(gene name synonym)|uniprotkb:DNCLI2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006132.1|refseq:NP_001273086.1|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0051642"(centrosome localization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|go:"GO:0000776"(kinetochore)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR027417|rcsb pdb:6F1T|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|ensembl:ENSG00000135720(gene)|ensembl:ENST00000258198(transcript)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WUEd3zgPhcKEe10gtoJ+okX8Zps9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UIG0	intact:EBI-1257113	intact:EBI-927482|uniprotkb:O95039|uniprotkb:O95247|uniprotkb:O95277|uniprotkb:B9EGK3|uniprotkb:Q6P1K4|uniprotkb:Q86UJ6|uniprotkb:D3DXE9|ensembl:ENSP00000342434|ensembl:ENSP00000385442	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:baz1b_human(display_long)|uniprotkb:BAZ1B(gene name)|psi-mi:BAZ1B(display_short)|uniprotkb:WBSC10(gene name synonym)|uniprotkb:WBSCR9(gene name synonym)|uniprotkb:WSTF(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 9 protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor(gene name synonym)|uniprotkb:WBSCR10(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 10 protein(gene name synonym)|uniprotkb:Bromodomain adjacent to zinc finger domain protein 1B(gene name synonym)|uniprotkb:hWALp2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115784.1|refseq:XP_016868262.1|dip:DIP-35642N|ensembl:ENSG00000009954(gene)|ensembl:ENST00000339594(transcript)|ensembl:ENST00000404251(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0035173"(histone kinase activity)|go:"GO:0042393"(histone binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037375|mint:Q9UIG0|rcsb pdb:1F62|rcsb pdb:5NNF|reactome:R-HSA-5250924|reactome:R-HSA-5693565	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1GTflhs9UUxTv4SPOYPKmuKAtSQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40818	intact:EBI-1257113	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62140	intact:EBI-1257113	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:A1L390	intact:EBI-1257113	intact:EBI-4401429|ensembl:ENSP00000247226|uniprotkb:A1L389|uniprotkb:B5MEC9|uniprotkb:O60339|uniprotkb:Q6GMS3|uniprotkb:Q6P4B1|uniprotkb:Q7L3S3|uniprotkb:Q86SW7|uniprotkb:Q8TEF5|uniprotkb:Q96EW6|uniprotkb:Q9BT82|intact:EBI-28970790	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkhg3_human(display_long)|uniprotkb:PLEKHG3(gene name)|psi-mi:PLEKHG3(display_short)|uniprotkb:KIAA0599(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000126822(gene)|ensembl:ENST00000247226(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR043324|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013408|ensembl:ENSP00000247226|ensembl:ENST00000394691|ensembl:ENSP00000378183|refseq:XP_016876646.1|refseq:NP_001295076.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+obep09w4klmkB8i13aA5FQW2609606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UL45	intact:EBI-1257113	intact:EBI-465781|ensembl:ENSP00000220531	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bl1s6_human(display_long)|uniprotkb:BLOC1S6(gene name)|psi-mi:BLOC1S6(display_short)|uniprotkb:PA(gene name synonym)|uniprotkb:PLDN(gene name synonym)|uniprotkb:Pallid protein homolog(gene name synonym)|uniprotkb:Pallidin(gene name synonym)|uniprotkb:Syntaxin 13-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000104164(gene)|ensembl:ENST00000220531(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0050942"(positive regulation of pigment cell differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR017242(BLOC-1 complex, pallidin subunit)|go:"GO:0031175"(neuron projection development)|interpro:IPR028119|mint:Q9UL45|reactome:R-HSA-432722|refseq:NP_036520.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:s5/ikwpqtA8Mm8gMd6ttfmBBKSA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H8W4	intact:EBI-1257113	intact:EBI-742388|ensembl:ENSP00000322373|ensembl:ENSP00000427792	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkhf2_human(display_long)|uniprotkb:Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains(gene name synonym)|uniprotkb:PLEKHF2(gene name)|psi-mi:PLEKHF2(display_short)|uniprotkb:ZFYVE18(gene name synonym)|uniprotkb:PH and FYVE domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 18(gene name synonym)|uniprotkb:Phafin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	mint:Q9H8W4|ensembl:ENSG00000175895(gene)|ensembl:ENST00000315367(transcript)|ensembl:ENST00000519516(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR037871|refseq:NP_078889.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:frYANUSmDIntPcZwWDW4YCQuMEw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BXB5	intact:EBI-1257113	intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92599	intact:EBI-1257113	intact:EBI-958021|uniprotkb:Q8IX36|uniprotkb:Q8IX37|uniprotkb:Q9BVB3|uniprotkb:A6NC65|uniprotkb:A6NKP6|ensembl:ENSP00000367991|uniprotkb:F6W7K9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept8_human(display_long)|uniprotkb:SEPTIN8(gene name)|psi-mi:SEPTIN8(display_short)|uniprotkb:KIAA0202(gene name synonym)|uniprotkb:SEPT8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001092281.1|refseq:NP_001092282.1|refseq:NP_001092283.1|refseq:NP_055961.1|refseq:NP_001287727.1|refseq:NP_001287728.1|ensembl:ENSG00000164402(gene)|ensembl:ENST00000378719(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031105"(septin complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032153"(cell division site)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030646|rcsb pdb:6UPR|rcsb pdb:6WSM	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QuM5Q14J4dl4Efbubz2wrqcyTiQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0H5	intact:EBI-1257113	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00161	intact:EBI-1257113	intact:EBI-745000|uniprotkb:O00162|uniprotkb:Q13602|uniprotkb:Q6IAE3|ensembl:ENSP00000249647	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snp23_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-23(gene name synonym)|uniprotkb:SNAP23(gene name)|psi-mi:SNAP23(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003816.2|refseq:NP_570710.1|ensembl:ENSG00000092531(gene)|ensembl:ENST00000249647(transcript)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043005"(neuron projection)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|mint:O00161|rcsb pdb:1NHL|rcsb pdb:3ZUS|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-1236974	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8ZcXbqhusSijGdekDMdkZA5DejY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O94979	intact:EBI-1257113	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P43487	intact:EBI-1257113	intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H9E3	intact:EBI-1257113	intact:EBI-368382|uniprotkb:Q96D40|uniprotkb:Q9BRF0|uniprotkb:Q9BVZ2|uniprotkb:Q9H5Y4|uniprotkb:Q9Y3W3|uniprotkb:B4DMN8|uniprotkb:C9JS23	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cog4_human(display_long)|uniprotkb:COG4(gene name)|psi-mi:COG4(display_short)|uniprotkb:Component of oligomeric Golgi complex 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	mint:Q9H9E3|refseq:NP_001182068.1|refseq:NP_056201.2|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048213"(Golgi vesicle prefusion complex stabilization)|interpro:IPR013167(COG4 transport)|rcsb pdb:3HR0|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|dip:DIP-32635N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Zphojrpw0bzNCK/pnMNps+K1y7U9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12756	intact:EBI-1257113	intact:EBI-2679809|uniprotkb:Q59GH1|uniprotkb:Q53T78|uniprotkb:Q2NKJ6|uniprotkb:Q7KZ57|uniprotkb:Q14752|uniprotkb:Q6P1R9|uniprotkb:Q4LE42|uniprotkb:O95068|uniprotkb:Q63Z40|uniprotkb:Q13355|uniprotkb:B0I1S5|uniprotkb:F5H045|ensembl:ENSP00000497030|ensembl:ENSP00000497824	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kif1a_human(display_long)|uniprotkb:ATSV(gene name synonym)|uniprotkb:C2orf20(gene name synonym)|uniprotkb:Axonal transporter of synaptic vesicles(gene name synonym)|uniprotkb:Microtubule-based motor KIF1A(gene name synonym)|uniprotkb:Unc-104- and KIF1A-related protein(gene name synonym)|uniprotkb:KIF1A(gene name)|psi-mi:KIF1A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001307634.1|refseq:NP_001230937.1|refseq:NP_004312.2|refseq:XP_016859880.1|dip:DIP-42405N|ensembl:ENSG00000130294(gene)|ensembl:ENST00000649096(transcript)|ensembl:ENST00000650053(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|rcsb pdb:4EGX|rcsb pdb:4EJQ|rcsb pdb:4UXO|rcsb pdb:4UXP|rcsb pdb:4UXS|reactome:R-HSA-6811434|reactome:R-HSA-983189|rcsb pdb:4UXR	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Gbsm6W6Tbp/2sEvu8qm9lyCfwS09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96TA1	intact:EBI-1257113	intact:EBI-2514593|uniprotkb:Q4LE55|uniprotkb:Q5VVW7|intact:EBI-28984656|ensembl:ENSP00000362409|uniprotkb:Q9NT35|uniprotkb:Q9BUS2|uniprotkb:Q5VVW6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:niba2_human(display_long)|uniprotkb:NIBAN2(gene name)|psi-mi:NIBAN2(display_short)|uniprotkb:C9orf88(gene name synonym)|uniprotkb:FAM129B(gene name synonym)|uniprotkb:Meg-3(gene name synonym)|uniprotkb:Melanoma invasion by ERK(gene name synonym)|uniprotkb:Niban-like protein 1(gene name synonym)|uniprotkb:Protein FAM129B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026088|mint:Q96TA1|rcsb pdb:7CTP|ensembl:ENSG00000136830(gene)|ensembl:ENST00000373312(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007411"(axon guidance)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032274"(gonadotropin secretion)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0045296"(cadherin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|refseq:NP_001030611.1|refseq:NP_073744.2|ensembl:ENSP00000362409|ensembl:ENST00000373314|ensembl:ENSP00000362411	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xdcw2BLz6uu0zyGi/NzvzPLrKUk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HD42	intact:EBI-1257113	intact:EBI-1057156|uniprotkb:Q14468|uniprotkb:Q15779|uniprotkb:Q96G31|uniprotkb:A2RU09|ensembl:ENSP00000380998	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chm1a_human(display_long)|uniprotkb:CHMP1A(gene name)|psi-mi:CHMP1A(display_short)|uniprotkb:CHMP1(gene name synonym)|uniprotkb:PCOLN3(gene name synonym)|uniprotkb:KIAA0047(gene name synonym)|uniprotkb:PRSM1(gene name synonym)|uniprotkb:Chromatin-modifying protein 1a(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002759.2|go:"GO:0036258"(multivesicular body assembly)|ensembl:ENSG00000131165(gene)|ensembl:ENST00000397901(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|interpro:IPR029888|mint:Q9HD42|rcsb pdb:2JQ9|rcsb pdb:2YMB|rcsb pdb:4A5X|reactome:R-HSA-9610379|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|dip:DIP-50647N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:w7fMwItYOqS/JXLy+8DWcJBaEPE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15127	intact:EBI-1257113	intact:EBI-712703|uniprotkb:Q9BQE8|intact:EBI-28966746|ensembl:ENSP00000268099|uniprotkb:B2RDF0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam2_human(display_long)|uniprotkb:SCAMP2(gene name)|psi-mi:SCAMP2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000268099|ensembl:ENSG00000140497(gene)|ensembl:ENST00000268099(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O15127|refseq:NP_005688.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wV3Omfpe2RLQlt8LYk8XUiuf20o9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96AJ9	intact:EBI-1257113	intact:EBI-3923262|uniprotkb:B4E137|uniprotkb:A2A307|ensembl:ENSP00000376792|uniprotkb:Q5W0D7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vti1a_human(display_long)|uniprotkb:VTI1A(gene name)|psi-mi:VTI1A(display_short)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_660207.2|ensembl:ENSG00000151532(gene)|ensembl:ENST00000393077(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|mint:Q96AJ9|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001305132.1|refseq:NP_001305134.1|refseq:XP_005269601.1|dip:DIP-44223N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MZOfyoq6Oe9cFxPKa3ZxWTuPTrI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q09666	intact:EBI-1257113	intact:EBI-2555881|ensembl:ENSP00000367263|uniprotkb:A1A586	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ahnk_human(display_long)|uniprotkb:PM227(gene name synonym)|uniprotkb:Desmoyokin(gene name synonym)|uniprotkb:AHNAK(gene name)|psi-mi:AHNAK(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001611.1|ensembl:ENSG00000124942(gene)|ensembl:ENST00000378024(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0031982"(vesicle)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q09666|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRG|refseq:NP_001333374.1|refseq:NP_001333375.1|refseq:NP_076965.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:u1oecAyIihgxzfTz0jholE8wksA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q07157	intact:EBI-1257113	intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q641Q2	intact:EBI-1257113	intact:EBI-2870155|intact:EBI-4401456|uniprotkb:A2A3S2|uniprotkb:A2A3U6|uniprotkb:Q5SNT6|uniprotkb:Q6DHY0|intact:EBI-28969894|ensembl:ENSP00000282633	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wac2a_human(display_long)|uniprotkb:WASHC2A(gene name)|psi-mi:WASHC2A(display_short)|uniprotkb:FAM21A(gene name synonym)|uniprotkb:FAM21B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000282633|ensembl:ENST00000351071|ensembl:ENSP00000344037|refseq:NP_001005751.1|refseq:NP_001278327.1|ensembl:ENSG00000099290(gene)|ensembl:ENST00000282633(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071203"(WASH complex)|interpro:IPR029341|mint:Q641Q2|go:"GO:0005769"(early endosome)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JtzABQxJJmBcNqKPsm/t5KJa2Lw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96AX1	intact:EBI-1257113	intact:EBI-2527283|uniprotkb:Q547V4|uniprotkb:Q9H5Q0|ensembl:ENSP00000267199	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp33a_human(display_long)|uniprotkb:VPS33A(gene name)|psi-mi:VPS33A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000139719(gene)|ensembl:ENST00000267199(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030220"(platelet formation)|go:"GO:0030897"(HOPS complex)|go:"GO:0032400"(melanosome localization)|go:"GO:0032418"(lysosome localization)|go:"GO:0033263"(CORVET complex)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|interpro:IPR043155|mint:Q96AX1|rcsb pdb:4BX8|rcsb pdb:4BX9|go:"GO:0031902"(late endosome membrane)|refseq:NP_075067.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dtPjiiMZ60tlBdhBPrYBHkXAUpE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95219	intact:EBI-1257113	intact:EBI-724909|uniprotkb:D3DNA3|uniprotkb:B4DQV4|uniprotkb:B3KMH0|ensembl:ENSP00000251775	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx4_human(display_long)|uniprotkb:SNX4(gene name)|psi-mi:SNX4(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003785.1|ensembl:ENSG00000114520(gene)|ensembl:ENST00000251775(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR027267|interpro:IPR034783|interpro:IPR034902|interpro:IPR036871|interpro:IPR037430|dip:DIP-36719N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Y/Dg8VrUYYvI5Xf67D3unhCjLDA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P08133	intact:EBI-1257113	intact:EBI-352541|uniprotkb:B7Z8A7|uniprotkb:E9PGK1|uniprotkb:Q6ZT79|uniprotkb:D3DQH4|ensembl:ENSP00000346550	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa6_human(display_long)|uniprotkb:ANXA6(gene name)|psi-mi:ANXA6(display_short)|uniprotkb:ANX6(gene name synonym)|uniprotkb:Annexin-6(gene name synonym)|uniprotkb:Annexin VI(gene name synonym)|uniprotkb:Lipocortin VI(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:p70(gene name synonym)|uniprotkb:Protein III(gene name synonym)|uniprotkb:Chromobindin-20(gene name synonym)|uniprotkb:67 kDa calelectrin(gene name synonym)|uniprotkb:Calphobindin-II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001146.2|refseq:NP_001180473.1|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008289"(lipid binding)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051283"(negative regulation of sequestering of calcium ion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENSG00000197043(gene)|ensembl:ENST00000354546(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003418"(growth plate cartilage chondrocyte differentiation)|interpro:IPR001464(Annexin)|interpro:IPR002393(Annexin, type VI)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|rcsb pdb:1M9I|reactome:R-HSA-445355	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+1oKdgl2a0haedrMSJ8au35MF8c9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P02786	intact:EBI-1257113	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H2T7	intact:EBI-1257113	intact:EBI-4401471|uniprotkb:Q8IU74|ensembl:ENSP00000427975	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rbp17_human(display_long)|uniprotkb:RANBP17(gene name)|psi-mi:RANBP17(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_075048.1|ensembl:ENSG00000204764(gene)|ensembl:ENST00000523189(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0051028"(mRNA transport)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR044189	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cow7k+yN9xWwktRRq0IezGxhnII9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P23458	intact:EBI-1257113	intact:EBI-1383438|uniprotkb:Q59GQ2|uniprotkb:Q9UD26|ensembl:ENSP00000343204|ensembl:ENSP00000499884|ensembl:ENSP00000499900|ensembl:ENSP00000500296|ensembl:ENSP00000500485|ensembl:ENSP00000500841	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:jak1_human(display_long)|uniprotkb:JAK1(gene name)|psi-mi:JAK1(display_short)|uniprotkb:JAK1A(gene name synonym)|uniprotkb:JAK1B(gene name synonym)|uniprotkb:Janus kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001308785.1|refseq:NP_002218.2|refseq:NP_001307852.1|refseq:NP_001308781.1|refseq:NP_001308782.1|refseq:NP_001308783.1|refseq:NP_001308784.1|dip:DIP-133N|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-909733|ensembl:ENSG00000162434(gene)|ensembl:ENST00000342505(transcript)|ensembl:ENST00000671929(transcript)|ensembl:ENST00000671954(transcript)|ensembl:ENST00000672179(transcript)|ensembl:ENST00000672247(transcript)|ensembl:ENST00000672434(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P23458|rcsb pdb:3EYG|rcsb pdb:3EYH|rcsb pdb:4E4L|rcsb pdb:4E4N|rcsb pdb:4E5W|rcsb pdb:4EHZ|rcsb pdb:4EI4|rcsb pdb:4FK6|rcsb pdb:4GS0|rcsb pdb:4I5C|rcsb pdb:4IVB|rcsb pdb:4IVC|rcsb pdb:4IVD|rcsb pdb:4K6Z|rcsb pdb:4K77|rcsb pdb:4L00|rcsb pdb:4L01|rcsb pdb:5E1E|rcsb pdb:5HX8|rcsb pdb:5IXD|rcsb pdb:5IXI|rcsb pdb:5KHW|rcsb pdb:5KHX|rcsb pdb:5L04|rcsb pdb:5WO4|rcsb pdb:6AAH|rcsb pdb:6BBU|rcsb pdb:6C7Y|rcsb pdb:6DBN|rcsb pdb:6ELR|rcsb pdb:6GGH|rcsb pdb:6HZU|rcsb pdb:6N77|rcsb pdb:6N78|rcsb pdb:6N79|rcsb pdb:6N7A|rcsb pdb:6N7B|rcsb pdb:6N7C|rcsb pdb:6N7D|rcsb pdb:6RSB|rcsb pdb:6RSC|rcsb pdb:6RSD|rcsb pdb:6RSE|rcsb pdb:6RSH|rcsb pdb:6SM8|rcsb pdb:6SMB|rcsb pdb:6TPE|rcsb pdb:6TPF|rcsb pdb:6W8L|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1169408|reactome:R-HSA-1266695|reactome:R-HSA-449836|reactome:R-HSA-5673001|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020591|reactome:R-HSA-9020956|reactome:R-HSA-9020958	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gEEiBAxwXnGGFWwO7OC0l0KjmSY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12929	intact:EBI-1257113	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UDY2	intact:EBI-1257113	intact:EBI-1042602|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1|intact:EBI-10989219|ensembl:ENSP00000366453|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001163886.1|refseq:NP_001163887.1|refseq:NP_004808.2|refseq:XP_011517508.1|refseq:XP_011517509.1|refseq:XP_011517510.1|refseq:XP_011517511.1|ensembl:ENSG00000119139(gene)|ensembl:ENST00000377245(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035598|interpro:IPR036028|interpro:IPR036034|mint:Q9UDY2|rcsb pdb:2OSG|rcsb pdb:3E17|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iN/EF8QWKtekoj5eON764eKAdpg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15691	intact:EBI-1257113	intact:EBI-1004115|uniprotkb:Q3KQS8|uniprotkb:B2R6I7|uniprotkb:E1P5M8|ensembl:ENSP00000364721	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mare1_human(display_long)|uniprotkb:APC-binding protein EB1(gene name synonym)|uniprotkb:End-binding protein 1(gene name synonym)|uniprotkb:MAPRE1(gene name)|psi-mi:MAPRE1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036457.1|refseq:XP_011526998.1|ensembl:ENSG00000101367(gene)|ensembl:ENST00000375571(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0016477"(cell migration)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:1903033"(positive regulation of microtubule plus-end binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:1904825"(protein localization to microtubule plus-end)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1905721"(mitotic spindle astral microtubule end)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR004953(EB1, C-terminal)|interpro:IPR027328|interpro:IPR027739|interpro:IPR036133|interpro:IPR036872|mint:Q15691|rcsb pdb:1PA7|rcsb pdb:1TXQ|rcsb pdb:1UEG|rcsb pdb:1VKA|rcsb pdb:1WU9|rcsb pdb:1YIB|rcsb pdb:1YIG|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2QJZ|rcsb pdb:2R8U|rcsb pdb:3GJO|rcsb pdb:3MTU|rcsb pdb:3MUD|rcsb pdb:3TQ7|rcsb pdb:4XA1|rcsb pdb:4XA3|rcsb pdb:4XA6|rcsb pdb:5JV3|rcsb pdb:5JVM|rcsb pdb:5JVP|rcsb pdb:5JVR|rcsb pdb:5JVS|rcsb pdb:5JVU|rcsb pdb:5JX1|rcsb pdb:5WLQ|rcsb pdb:6PF2|rcsb pdb:6PFP|rcsb pdb:6YF5|rcsb pdb:6YSH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|dip:DIP-38018N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+JBCBM7dbbrxn6mX8RiwejYWJ2U9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61225	intact:EBI-1257113	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14653	intact:EBI-1257113	intact:EBI-4401517|uniprotkb:D3DXJ6|uniprotkb:D3DXJ5|uniprotkb:Q96DA5|uniprotkb:Q9BZZ4|uniprotkb:Q8N4B8|ensembl:ENSP00000492751	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gosr2_human(display_long)|uniprotkb:GOSR2(gene name)|psi-mi:GOSR2(display_short)|uniprotkb:GS27(gene name synonym)|uniprotkb:27 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:Membrin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012529.1|refseq:NP_004278.2|refseq:NP_473363.1|ensembl:ENSG00000108433(gene)|ensembl:ENST00000640051(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|rcsb pdb:3EG9|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811438	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RWoVhfrHKdtVMlLtb5NRU/R2wRY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TAG9	intact:EBI-1257113	intact:EBI-1223394|uniprotkb:Q9NZ24|uniprotkb:Q5VXH8|uniprotkb:E9PHI3|ensembl:ENSP00000260762	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc6_human(display_long)|uniprotkb:EXOC6(gene name)|psi-mi:EXOC6(display_short)|uniprotkb:SEC15A(gene name synonym)|uniprotkb:SEC15L(gene name synonym)|uniprotkb:SEC15L1(gene name synonym)|uniprotkb:Exocyst complex component Sec15A(gene name synonym)|uniprotkb:SEC15-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001013870.1|refseq:NP_061926.3|refseq:XP_016871834.1|refseq:NP_001306123.1|refseq:NP_001306124.1|refseq:NP_001306129.1|ensembl:ENSG00000138190(gene)|ensembl:ENST00000260762(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007225(Exocyst complex subunit Sec15-like)|interpro:IPR042044|interpro:IPR042045|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|mint:Q8TAG9	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M+NozbnYI3iV+onpii45135rGio9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5X3	intact:EBI-1257113	intact:EBI-715760|uniprotkb:Q52LC4|uniprotkb:B7ZKN3|uniprotkb:Q9BWP0|uniprotkb:Q7KZN0|uniprotkb:D3DW26|ensembl:ENSP00000366988|ensembl:ENSP00000366998	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx5_human(display_long)|uniprotkb:SNX5(gene name)|psi-mi:SNX5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055241.1|refseq:NP_689413.1|ensembl:ENSG00000089006(gene)|ensembl:ENST00000377759(transcript)|ensembl:ENST00000377768(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006907"(pinocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034452"(dynactin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070685"(macropinocytic cup)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097422"(tubular endosome)|interpro:IPR001683(Phox-like)|interpro:IPR014637(Sorting nexin, Snx5/Snx6 types)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028654|interpro:IPR036871|interpro:IPR042135|mint:Q9Y5X3|rcsb pdb:1SYS|rcsb pdb:5TGH|rcsb pdb:5TGI|rcsb pdb:5TGJ|rcsb pdb:5WY2|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6N5Z|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VR2oUxQ4M2bm5zKeHQlao046QL09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IYI6	intact:EBI-1257113	intact:EBI-742102|ensembl:ENSP00000355605|uniprotkb:Q5TE82|uniprotkb:B3KU33	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc8_human(display_long)|uniprotkb:Exocyst complex 84 kDa subunit(gene name synonym)|uniprotkb:EXOC8(gene name)|psi-mi:EXOC8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000116903(gene)|go:"GO:0031252"(cell leading edge)|ensembl:ENST00000366645(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005770"(late endosome)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_787072.2|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR032403|interpro:IPR033961|interpro:IPR042560|interpro:IPR042561|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VXQFBw3zltr9eQ/3EgdLszUZbbs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P85298	intact:EBI-1257113	intact:EBI-4289876|uniprotkb:Q9NVX8|uniprotkb:Q9HC46|uniprotkb:Q9HA49|uniprotkb:O75983|uniprotkb:Q96RW2|uniprotkb:Q9NXL1|uniprotkb:O95695|uniprotkb:Q9UH20|uniprotkb:Q9NSG0|uniprotkb:Q96RW1|uniprotkb:A6ZJ80|ensembl:ENSP00000374424|uniprotkb:A6ZJ79	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg08_human(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036865|reactome:R-HSA-8980692|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|ensembl:ENSG00000241484(gene)|ensembl:ENST00000389774(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000198(RhoGAP)|refseq:NP_001017526.1|refseq:NP_001185655.1|refseq:NP_851852.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UqN4Tj7Wd/7NqV7exVGSjtYC+Qc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NSK0	intact:EBI-1257113	intact:EBI-949319|intact:EBI-28986540|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENSP00000418031|uniprotkb:Q66K28|uniprotkb:B3KPI3|uniprotkb:B3KSQ3|uniprotkb:B3KNY4|uniprotkb:B4DME9|uniprotkb:Q96EG6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc4_human(display_long)|uniprotkb:Kinesin-like protein 8(gene name synonym)|uniprotkb:KLC4(gene name)|psi-mi:KLC4(display_short)|uniprotkb:KNSL8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000137171(gene)|ensembl:ENST00000347162(transcript)|ensembl:ENST00000394056(transcript)|ensembl:ENST00000479388(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_612352.1|refseq:NP_958929.1|refseq:NP_958930.1|refseq:NP_958931.1|refseq:NP_001275963.1|refseq:NP_001275964.1|ensembl:ENST00000259708|ensembl:ENSP00000259708|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENST00000453940|ensembl:ENSP00000395806|ensembl:ENST00000458460|ensembl:ENSP00000410358|ensembl:ENST00000467906|ensembl:ENSP00000418759|ensembl:ENSP00000418031	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8wcjm5q5W1xiMTe50m3hpL4jy609606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15321	intact:EBI-1257113	intact:EBI-1390491|uniprotkb:Q96FI8|uniprotkb:D3DS65|uniprotkb:Q86SZ6|intact:EBI-28976916|ensembl:ENSP00000261789|ensembl:ENSP00000494320	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tm9s1_human(display_long)|uniprotkb:TM9SF1(gene name)|psi-mi:TM9SF1(display_short)|uniprotkb:MP70 protein family member(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001014842.1|refseq:NP_006396.2|ensembl:ENSP00000494320|ensembl:ENSP00000261789|ensembl:ENST00000396854|ensembl:ENSP00000380063|ensembl:ENST00000646500|ensembl:ENSP00000494851|refseq:NP_001275935.1|ensembl:ENSG00000100926(gene)|ensembl:ENSG00000285465(gene)|ensembl:ENST00000261789(transcript)|ensembl:ENST00000646762(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:y4t2+OC3qVXBRLxyH65ywVx8Ja09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q3YEC7	intact:EBI-1257113	intact:EBI-742029|uniprotkb:A8QVZ7|uniprotkb:Q4F968|uniprotkb:Q5T5R7|uniprotkb:Q8IWK1|uniprotkb:Q8TCL4|uniprotkb:Q8WU94|uniprotkb:Q96SR8|uniprotkb:Q9BU21|uniprotkb:Q9H935|uniprotkb:A8QVZ8|uniprotkb:C6K8I4|uniprotkb:C6K8I5|ensembl:ENSP00000311134	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rabl6_human(display_long)|uniprotkb:RABL6(gene name)|psi-mi:RABL6(display_short)|uniprotkb:C9orf86(gene name synonym)|uniprotkb:GTP-binding protein Parf(gene name synonym)|uniprotkb:PARF(gene name synonym)|uniprotkb:Partner of ARF(gene name synonym)|uniprotkb:Rab-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001167459.1|refseq:NP_078994.3|refseq:NP_001167460.1|ensembl:ENSG00000196642(gene)|ensembl:ENST00000311502(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR040385|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AZhkTh4+32Qxv5/Dy4ebg+mv3Ls9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99829	intact:EBI-1257113	intact:EBI-1642542|uniprotkb:E1P5Q4|uniprotkb:Q6IBL3|uniprotkb:Q9H243|uniprotkb:Q9NTZ7|ensembl:ENSP00000336945|ensembl:ENSP00000380585	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cpne1_human(display_long)|uniprotkb:CPNE1(gene name)|psi-mi:CPNE1(display_short)|uniprotkb:CPN1(gene name synonym)|uniprotkb:Copine I(gene name synonym)|uniprotkb:Chromobindin 17(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003906.2|refseq:NP_690902.1|refseq:NP_690903.1|refseq:NP_690904.1|refseq:NP_690905.1|ensembl:ENSG00000214078(gene)|ensembl:ENST00000352393(transcript)|ensembl:ENST00000397443(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005215"(transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:Q99829|reactome:R-HSA-1483206|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Mtq9BQZT1fdT+JigvKinqBWAh9w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12846	intact:EBI-1257113	intact:EBI-744942|uniprotkb:Q15525|ensembl:ENSP00000317714|uniprotkb:Q6FHE8|uniprotkb:A8MXY0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-31(gene name synonym)|uniprotkb:STX4(gene name)|psi-mi:STX4(display_short)|uniprotkb:STX4A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000103496(gene)|refseq:NP_004595.2|ensembl:ENST00000313843(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|reactome:R-HSA-114516|reactome:R-HSA-1236974|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-449836|interpro:IPR006011(Syntaxin, N-terminal)|refseq:NP_001259025.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NvOLGIGe/XO2aDPSpdPzrtKniZY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WXH0	intact:EBI-1257113	intact:EBI-2372294|uniprotkb:Q540G1|uniprotkb:Q8N1S3|uniprotkb:Q8NF49|uniprotkb:Q8TER7|uniprotkb:Q8WWW3|uniprotkb:Q8WWW4|uniprotkb:Q8WWW5|uniprotkb:Q8WXH1|uniprotkb:Q9NU50|uniprotkb:Q9UFQ4|uniprotkb:Q9Y2L4|uniprotkb:Q9Y4R1|uniprotkb:Q86YP9|uniprotkb:B4DND7|uniprotkb:B4DPR6|uniprotkb:I6XXQ5|ensembl:ENSP00000341781	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:syne2_human(display_long)|uniprotkb:SYNE2(gene name)|psi-mi:SYNE2(display_short)|uniprotkb:KIAA1011(gene name synonym)|uniprotkb:NUA(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000344528|ensembl:ENSP00000341781|ensembl:ENST00000358025|ensembl:ENSP00000350719|ensembl:ENST00000458046|ensembl:ENSP00000391937|ensembl:ENST00000555002|ensembl:ENSP00000450831|ensembl:ENST00000341472|refseq:NP_055995.4|refseq:NP_878914.1|refseq:NP_878917.1|refseq:NP_878918.2|dip:DIP-53409N|ensembl:ENSG00000054654(gene)|ensembl:ENST00000344113(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR030266|interpro:IPR036872|rcsb pdb:4DXS|rcsb pdb:4FI9|rcsb pdb:6XF1|reactome:R-HSA-1221632	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wLHWOXR+dUHkcs93g+F2av/9wm49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15404	intact:EBI-1257113	intact:EBI-1057132|uniprotkb:Q6FI17|uniprotkb:D3DRU3|uniprotkb:A8KA46|ensembl:ENSP00000339521|ensembl:ENSP00000367154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rsu1_human(display_long)|uniprotkb:RSU1(gene name)|psi-mi:RSU1(display_short)|uniprotkb:RSP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689937.2|refseq:NP_036557.1|ensembl:ENSG00000148484(gene)|ensembl:ENST00000345264(transcript)|ensembl:ENST00000377921(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT8|rcsb pdb:7LT9|reactome:R-HSA-446388	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QZduUWmFxzAxRHmcdDbCQlm6tBQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5HYI8	intact:EBI-1257113	intact:EBI-2824032|uniprotkb:Q8WUD3|ensembl:ENSP00000273375	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rabl3_human(display_long)|uniprotkb:RABL3(gene name)|psi-mi:RABL3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000144840(gene)|ensembl:ENST00000273375(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:1903059"(regulation of protein lipidation)|interpro:IPR027417|mint:Q5HYI8|go:"GO:0050821"(protein stabilization)|refseq:NP_776186.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wa/T6PILk7wiphCKdnT3OidKB0E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5W7	intact:EBI-1257113	intact:EBI-4401489|uniprotkb:Q6PI37|uniprotkb:Q9BSD1|uniprotkb:B4DI55|uniprotkb:Q4VBR3|uniprotkb:Q5TCF9|uniprotkb:Q5TCG0|uniprotkb:Q6NUI7|ensembl:ENSP00000313121	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx14_human(display_long)|uniprotkb:SNX14(gene name)|psi-mi:SNX14(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065201.1|refseq:NP_722523.1|refseq:NP_001291408.1|refseq:NP_001284543.1|ensembl:ENSG00000135317(gene)|ensembl:ENST00000314673(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036305|interpro:IPR036871|interpro:IPR037436|interpro:IPR037892|rcsb pdb:4BGJ|rcsb pdb:4PQO|rcsb pdb:4PQP	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:a+twl6lGEpR7hRX/P6mYruxJPEw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11279	intact:EBI-1257113	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJC3	intact:EBI-1257113	intact:EBI-746704|uniprotkb:O60561|uniprotkb:Q5TG44|uniprotkb:A8MU44|uniprotkb:B4DX15|uniprotkb:A8K8E9|intact:EBI-10969618|ensembl:ENSP00000360252	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hook1_human(display_long)|uniprotkb:HOOK1(gene name)|psi-mi:HOOK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056972.1|ensembl:ENSG00000134709(gene)|ensembl:ENST00000371208(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905198"(manchette assembly)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q9UJC3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QOcYbuKfnNIlNKzos5v+0+A2h3I9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P10253	intact:EBI-1257113	intact:EBI-2830238|uniprotkb:Q8IWE7|uniprotkb:Q09GN4|uniprotkb:Q16302|uniprotkb:Q14351|ensembl:ENSP00000305692|ensembl:ENSP00000374665	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lyag_human(display_long)|uniprotkb:GAA(gene name)|psi-mi:GAA(display_short)|uniprotkb:Acid maltase(gene name synonym)|uniprotkb:Aglucosidase alfa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR017957|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|interpro:IPR031727|rcsb pdb:5KZW|rcsb pdb:5NN3|rcsb pdb:5NN4|rcsb pdb:5NN5|rcsb pdb:5NN6|rcsb pdb:5NN8|reactome:R-HSA-5357609|reactome:R-HSA-6798695|reactome:R-HSA-70221|rcsb pdb:5KZX|refseq:NP_000143.2|refseq:NP_001073271.1|refseq:NP_001073272.1|refseq:XP_005257250.1|refseq:XP_005257251.1|ensembl:ENSG00000171298(gene)|ensembl:ENST00000302262(transcript)|ensembl:ENST00000390015(transcript)|go:"GO:0000023"(maltose metabolic process)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0004558"(alpha-1,4-glucosidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0005985"(sucrose metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032450"(maltose alpha-glucosidase activity)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043181"(vacuolar sequestering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090599"(alpha-glucosidase activity)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR000519(P-type trefoil)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LqHRnythO4WRf8H74OqWoImqZJA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14108	intact:EBI-1257113	intact:EBI-1564650|uniprotkb:Q53Y63|uniprotkb:B4DKD8|uniprotkb:E7EM68|ensembl:ENSP00000264896	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scrb2_human(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:SCARB2(gene name)|psi-mi:SCARB2(display_short)|uniprotkb:CD36L2(gene name synonym)|uniprotkb:LIMPII(gene name synonym)|uniprotkb:LIMP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001191184.1|refseq:NP_005497.1|ensembl:ENSG00000138760(gene)|ensembl:ENST00000264896(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010008"(endosome membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904978"(regulation of endosome organization)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905671"(regulation of lysosome organization)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:Q14108|rcsb pdb:4F7B|rcsb pdb:4Q4B|rcsb pdb:4Q4F|rcsb pdb:4TVZ|rcsb pdb:4TW0|rcsb pdb:4TW2|rcsb pdb:5UPH|rcsb pdb:5XBM|rcsb pdb:6I2K|reactome:R-HSA-8856825|reactome:R-HSA-8856828	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FXyG5dJv7OqGjSgl5slIqNxUqoI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5W8	intact:EBI-1257113	intact:EBI-3917449|uniprotkb:B2RCI9|uniprotkb:Q8WXH8|uniprotkb:Q8WVZ2|uniprotkb:O94821	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx13_human(display_long)|uniprotkb:SNX13(gene name)|psi-mi:SNX13(display_short)|uniprotkb:KIAA0713(gene name synonym)|uniprotkb:RGS domain- and PHOX domain-containing protein(gene name synonym)|uniprotkb:RGS-PX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR036305|interpro:IPR036871|interpro:IPR037896|refseq:NP_055947.1|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR013937(Sorting nexin, C-terminal)|refseq:XP_005249729.1|go:"GO:0005769"(early endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR037437	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Yyf+DFRzaSwLMeAgcJoPEqAqIhE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15286	intact:EBI-1257113	intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H9C1	intact:EBI-1257113	intact:EBI-749080|uniprotkb:O95434|uniprotkb:Q9H7E1|uniprotkb:Q9H9I9|uniprotkb:B4DPI6|ensembl:ENSP00000339122|ensembl:ENSP00000452181|ensembl:ENSP00000452191	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:spe39_human(display_long)|uniprotkb:VIPAS39(gene name)|psi-mi:VIPAS39(display_short)|uniprotkb:C14orf133(gene name synonym)|uniprotkb:SPE39(gene name synonym)|uniprotkb:VIPAR(gene name synonym)|uniprotkb:VPS33B-interacting protein in apical-basolateral polarity regulator(gene name synonym)|uniprotkb:VPS33B-interacting protein in polarity and apical restriction(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001180243.1|refseq:NP_001180244.1|refseq:NP_001180246.1|refseq:NP_071350.2|refseq:NP_001180245.1|ensembl:ENSG00000151445(gene)|ensembl:ENST00000343765(transcript)|ensembl:ENST00000553888(transcript)|ensembl:ENST00000557658(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0055037"(recycling endosome)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR038132|interpro:IPR040057|mint:Q9H9C1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Th3K4elgRIPP7DHwIRBN+GKNOXM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61586	intact:EBI-1257113	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14185	intact:EBI-1257113	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y365	intact:EBI-1257113	intact:EBI-4289836|uniprotkb:O60532|ensembl:ENSP00000335247|ensembl:ENSP00000438792	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sta10_human(display_long)|uniprotkb:STARD10(gene name)|psi-mi:STARD10(display_short)|uniprotkb:SDCCAG28(gene name synonym)|uniprotkb:Antigen NY-CO-28(gene name synonym)|uniprotkb:Serologically defined colon cancer antigen 28(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 10(gene name synonym)|uniprotkb:CGI-52(orf name)|uniprotkb:PCTP-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000214530(gene)|ensembl:ENST00000334805(transcript)|ensembl:ENST00000543304(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0006869"(lipid transport)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0046581"(intercellular canaliculus)|interpro:IPR002913(Lipid-binding START)|interpro:IPR023393|interpro:IPR041951|mint:Q9Y365|rcsb pdb:6SER|reactome:R-HSA-1483191|refseq:NP_006636.2	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dT74wCec5ul2kdfqw0RH5axrocM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P20340	intact:EBI-1257113	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BRG1	intact:EBI-1257113	intact:EBI-741945|uniprotkb:B2R581|ensembl:ENSP00000253794	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps25_human(display_long)|uniprotkb:ELL-associated protein of 20 kDa(gene name synonym)|uniprotkb:Dermal papilla-derived protein 9(gene name synonym)|uniprotkb:VPS25(gene name)|psi-mi:VPS25(display_short)|uniprotkb:DERP9(gene name synonym)|uniprotkb:EAP20(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000253794(transcript)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000131475(gene)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008570(ESCRT-II complex, vps25 subunit)|interpro:IPR014041(ESCRT-II complex, vps25 subunit, N-terminal winged helix)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2ZME|rcsb pdb:3CUQ|rcsb pdb:3HTU|reactome:R-HSA-917729|reactome:R-HSA-9610379|refseq:NP_115729.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fAf3o5rwpM1xz53oIyMwohQfbEg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92783	intact:EBI-1257113	intact:EBI-752333|uniprotkb:Q8N6D9|uniprotkb:B0YJ99|intact:EBI-3447129|uniprotkb:D3DRU5|intact:EBI-28983444|ensembl:ENSP00000366746	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stam1_human(display_long)|uniprotkb:STAM(gene name)|psi-mi:STAM(display_short)|uniprotkb:STAM1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003464.1|ensembl:ENSP00000366746|dip:DIP-37761N|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035657|interpro:IPR036028|mint:Q92783|rcsb pdb:2L0A|rcsb pdb:3F1I|rcsb pdb:3LDZ|reactome:R-HSA-182971|reactome:R-HSA-5689901|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|ensembl:ENSG00000136738(gene)|ensembl:ENST00000377524(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016236"(macroautophagy)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+XzmsTsMqOFTM5SM1fuVB+0UzeQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UPT5	intact:EBI-1257113	intact:EBI-720048|uniprotkb:Q96FF0|uniprotkb:Q9H8C3|uniprotkb:Q9H9X3|uniprotkb:Q9HA32|uniprotkb:Q8ND93|uniprotkb:Q8WV91|uniprotkb:B5MC69|uniprotkb:B8XXP2|ensembl:ENSP00000334100	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc7_human(display_long)|uniprotkb:EXOC7(gene name)|psi-mi:EXOC7(display_short)|uniprotkb:EXO70(gene name synonym)|uniprotkb:KIAA1067(gene name synonym)|uniprotkb:Exocyst complex component Exo70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001013861.1|refseq:NP_001138769.1|refseq:NP_001138770.1|refseq:NP_001138771.1|refseq:NP_056034.2|ensembl:ENSG00000182473(gene)|ensembl:ENST00000335146(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032584"(growth cone membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR004140(Exo70 exocyst complex subunit)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UPT5|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_001269242.1|dip:DIP-37604N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f/uwscxIcAuG96QZzNMQtrzTmeU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15836	intact:EBI-1257113	intact:EBI-722343|uniprotkb:Q9BRV4|ensembl:ENSP00000054666	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vamp3_human(display_long)|uniprotkb:Synaptobrevin-3(gene name synonym)|uniprotkb:Cellubrevin(gene name synonym)|uniprotkb:VAMP3(gene name)|psi-mi:VAMP3(display_short)|uniprotkb:SYB3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004772.1|dip:DIP-56422N|ensembl:ENSG00000049245(gene)|ensembl:ENST00000054666(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903531"(negative regulation of secretion by cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q15836|reactome:R-HSA-1236974|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JeCaIwh36OpRqMG0MFnpFZyN6jU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NZ43	intact:EBI-1257113	intact:EBI-742842|uniprotkb:Q8NCK1|uniprotkb:Q9BRT4|ensembl:ENSP00000263897	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:use1_human(display_long)|uniprotkb:USE1L(gene name synonym)|uniprotkb:USE1-like protein(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM26(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:USE1(gene name)|psi-mi:USE1(display_short)|uniprotkb:MDS032(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060937.1|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007041"(lysosomal transport)|go:"GO:0015031"(protein transport)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031201"(SNARE complex)|go:"GO:0032940"(secretion by cell)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR019150|reactome:R-HSA-6811434|ensembl:ENSG00000053501(gene)|ensembl:ENST00000263897(transcript)|go:"GO:0005484"(SNAP receptor activity)|refseq:XP_016882464.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Q1yMpc/L7/G3M+SehF5ix99OkVM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBQ0	intact:EBI-1257113	intact:EBI-718596|uniprotkb:Q502Y5|uniprotkb:Q9H0W0|uniprotkb:Q9NRP1|uniprotkb:Q6FIF8|uniprotkb:Q6IAH3|uniprotkb:Q9NRU7|ensembl:ENSP00000447058	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps29_human(display_long)|uniprotkb:Vesicle protein sorting 29(gene name synonym)|uniprotkb:PEP11 homolog(gene name synonym)|uniprotkb:VPS29(gene name)|psi-mi:VPS29(display_short)|uniprotkb:DC7(orf name)|uniprotkb:DC15(orf name)|uniprotkb:MDS007(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057310.1|refseq:NP_476528.1|ensembl:ENSG00000111237(gene)|ensembl:ENST00000549578(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|rcsb pdb:1W24|rcsb pdb:2R17|rcsb pdb:5GTU|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:5WYH|rcsb pdb:7BLN|reactome:R-HSA-3238698|dip:DIP-29077N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xjo28jAH7expkdli0DENjzLXpjw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BRK5	intact:EBI-1257113	intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95249	intact:EBI-1257113	intact:EBI-3235244|ensembl:ENSP00000225724|uniprotkb:O75392|uniprotkb:J3KST5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gosr1_human(display_long)|uniprotkb:GOSR1(gene name)|psi-mi:GOSR1(display_short)|uniprotkb:GS28(gene name synonym)|uniprotkb:28 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:28 kDa cis-Golgi SNARE p28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000108587(gene)|ensembl:ENST00000225724(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048209"(regulation of vesicle targeting, to, from or within Golgi)|interpro:IPR023601|mint:O95249|reactome:R-HSA-6807878|reactome:R-HSA-6811438|refseq:NP_001007025.1|refseq:NP_001007026.1|refseq:NP_004862.1|refseq:XP_005258129.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zebOuVPnYg5z3XqCa5rMI2IR/jY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UKX7	intact:EBI-1257113	intact:EBI-2371082|uniprotkb:O75644|uniprotkb:Q9NPM9|uniprotkb:Q9NPR6|uniprotkb:Q9P1K5|uniprotkb:B2RB15|uniprotkb:B1AHA4|uniprotkb:Q8N6V5|ensembl:ENSP00000345895	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nup50_human(display_long)|uniprotkb:NUP50(gene name)|psi-mi:NUP50(display_short)|uniprotkb:NPAP60L(gene name synonym)|uniprotkb:Nuclear pore-associated protein 60 kDa-like(gene name synonym)|uniprotkb:PRO1146(orf name)|uniprotkb:Nucleoporin Nup50(gene name synonym)|uniprotkb:50 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011528135.1|refseq:NP_009103.2|refseq:NP_705931.1|refseq:XP_006724166.1|refseq:XP_006724167.1|refseq:XP_005261369.1|refseq:XP_005261371.1|refseq:XP_016884026.1|ensembl:ENSG00000093000(gene)|ensembl:ENST00000347635(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015007("NUP50 (Nucleoporin 50 kDa)")|mint:Q9UKX7|rcsb pdb:2EC1|rcsb pdb:3TJ3|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tg/qpkdGAm/M6vLvvCzdTCZoxiA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15382	intact:EBI-1257113	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P20339	intact:EBI-1257113	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00499	intact:EBI-1257113	intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H7D0	intact:EBI-1257113	intact:EBI-1773858|uniprotkb:Q5XKD5|uniprotkb:Q6AI11|uniprotkb:Q6PJS6|uniprotkb:Q6ZTS6|uniprotkb:B2RNY0|ensembl:ENSP00000276440|intact:EBI-28975706	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dock5_human(display_long)|uniprotkb:DOCK5(gene name)|psi-mi:DOCK5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000276440|ensembl:ENST00000481100|ensembl:ENSP00000429737|refseq:NP_079216.4|ensembl:ENSG00000147459(gene)|ensembl:ENST00000276440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904694"(negative regulation of vascular associated smooth muscle contraction)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR030717|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q9H7D0|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-983231|go:"GO:0007264"(small GTPase mediated signal transduction)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/+sUfMB7hLZjdyhsMQ8WKJoXXLU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BTC0	intact:EBI-1257113	intact:EBI-739985|uniprotkb:O15043|uniprotkb:A8MY65|uniprotkb:Q3ZTL7|uniprotkb:Q3ZTL8|uniprotkb:Q4VXS1|uniprotkb:Q4VXS2|uniprotkb:Q4VXV8|uniprotkb:Q96D72|uniprotkb:Q9BQW0|uniprotkb:Q9BW03|uniprotkb:Q9H4G6|uniprotkb:Q9H4G7|uniprotkb:Q9NTU8|uniprotkb:Q9NUM8|uniprotkb:Q9UFB6|uniprotkb:B9EH82|uniprotkb:Q4VXV9|uniprotkb:E1P5I1|intact:EBI-28975591|ensembl:ENSP00000266070|ensembl:ENSP00000378752	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dido1_human(display_long)|uniprotkb:DIDO1(gene name)|psi-mi:DIDO1(display_short)|uniprotkb:Death-associated transcription factor 1(gene name synonym)|uniprotkb:C20orf158(gene name synonym)|uniprotkb:DATF1(gene name synonym)|uniprotkb:KIAA0333(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000266070|ensembl:ENST00000354665|ensembl:ENSP00000346692|ensembl:ENST00000370366|ensembl:ENSP00000359391|ensembl:ENST00000370368|ensembl:ENSP00000359394|ensembl:ENST00000370371|ensembl:ENSP00000359397|ensembl:ENST00000395340|ensembl:ENSP00000378749|ensembl:ENSP00000378752|refseq:NP_001180298.1|refseq:NP_001180299.1|refseq:NP_071388.2|refseq:NP_149072.2|refseq:NP_542986.1|refseq:NP_542987.2|ensembl:ENSG00000101191(gene)|ensembl:ENST00000266070(transcript)|ensembl:ENST00000395343(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003618(Transcription elongation factor S-II, central region)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR033082|interpro:IPR036575|mint:Q9BTC0|rcsb pdb:2M3H|rcsb pdb:4L7X|reactome:R-HSA-1221632|refseq:XP_011526811.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xtp4cq/633PxqppXYlVvameuI7M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50570	intact:EBI-1257113	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46734	intact:EBI-1257113	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9C0E2	intact:EBI-1257113	intact:EBI-1044855|uniprotkb:Q5VUZ5|uniprotkb:Q9H934|uniprotkb:Q8N3V6|ensembl:ENSP00000255305	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpo4_human(display_long)|uniprotkb:XPO4(gene name)|psi-mi:XPO4(display_short)|uniprotkb:KIAA1721(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071904.4|ensembl:ENSG00000132953(gene)|ensembl:ENST00000255305(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR044189|mint:Q9C0E2|go:"GO:0005643"(nuclear pore)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+7lQFg9CBnDLFt9rqjLb//HPJnQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46060	intact:EBI-1257113	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00169	intact:EBI-1257113	intact:EBI-1042490|ensembl:ENSP00000316809	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pipna_human(display_long)|uniprotkb:PITPNA(gene name)|psi-mi:PITPNA(display_short)|uniprotkb:PITPN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006215.1|ensembl:ENSG00000174238(gene)|ensembl:ENST00000313486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0015914"(phospholipid transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:1901611"(phosphatidylglycerol binding)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR023393|rcsb pdb:1UW5|reactome:R-HSA-418890|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KMZulqZC4p4zElJFjDS448WYFnI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96M96	intact:EBI-1257113	intact:EBI-4401039|uniprotkb:Q6ULS2|uniprotkb:Q8TCP6|ensembl:ENSP00000394487|ensembl:ENSP00000433666|ensembl:ENSP00000462623	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fgd4_human(display_long)|uniprotkb:FGD4(gene name)|psi-mi:FGD4(display_short)|uniprotkb:FRABP(gene name synonym)|uniprotkb:ZFYVE6(gene name synonym)|uniprotkb:Actin filament-binding protein frabin(gene name synonym)|uniprotkb:FGD1-related F-actin-binding protein(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_640334.2|refseq:NP_001291409.1|refseq:XP_011518857.1|refseq:XP_011518858.1|refseq:NP_001317303.1|refseq:NP_001317302.1|ensembl:ENSG00000139132(gene)|ensembl:ENST00000427716(transcript)|ensembl:ENST00000525053(transcript)|ensembl:ENST00000583694(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035899|interpro:IPR035941|interpro:IPR037742|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-9013148|interpro:IPR017455(Zinc finger, FYVE-related)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:K4gzeBUhltm9N1SSPFdtgrmYsu89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15833	intact:EBI-1257113	intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40616	intact:EBI-1257113	intact:EBI-1052746|uniprotkb:P80417|uniprotkb:Q53XB1|uniprotkb:B4DWW1|ensembl:ENSP00000261636|intact:EBI-11157530	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl1_human(display_long)|uniprotkb:ARL1(gene name)|psi-mi:ARL1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001168.1|ensembl:ENSG00000120805(gene)|ensembl:ENST00000261636(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P40616|rcsb pdb:1UPT|rcsb pdb:4DCN|rcsb pdb:5EE5|rcsb pdb:5J5C|reactome:R-HSA-6811440|interpro:IPR005225(Small GTP-binding protein)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:4sRUSYrH1mt5ol85HlMNSEn1j9M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NR50	intact:EBI-1257113	intact:EBI-702257|uniprotkb:Q5QP89|uniprotkb:Q5QP90|uniprotkb:Q8NDB5|uniprotkb:Q8WV57|uniprotkb:Q9H850|uniprotkb:B2RBH8|uniprotkb:D3DPZ2|ensembl:ENSP00000353575	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ei2bg_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:EIF2B3(gene name)|psi-mi:EIF2B3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001160060.1|refseq:NP_065098.1|refseq:NP_001248347.1|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|rcsb pdb:7D45|ensembl:ENST00000360403(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000070785(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025877|interpro:IPR029044|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wGjFfKA+E5rYJfmocP6qcTQ9+SU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WUM4	intact:EBI-1257113	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P08107	intact:EBI-1257113	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60749	intact:EBI-1257113	intact:EBI-1046690|uniprotkb:O43650|uniprotkb:P82862|uniprotkb:Q53XK8|uniprotkb:Q597H6|uniprotkb:Q9BTS8|ensembl:ENSP00000368831|uniprotkb:B3KN44|uniprotkb:B4DEK4|uniprotkb:B7Z408	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx2_human(display_long)|uniprotkb:Transformation-related gene 9 protein(gene name synonym)|uniprotkb:SNX2(gene name)|psi-mi:SNX2(display_short)|uniprotkb:TRG9(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003091.2|ensembl:ENSG00000205302(gene)|ensembl:ENST00000379516(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028653|interpro:IPR037918|mint:O60749|interpro:IPR036871|reactome:R-HSA-432722|refseq:NP_001265128.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Sb/i4ZNGqy+ixeexnp0/4uOo3jo9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13144	intact:EBI-1257113	intact:EBI-4401110|uniprotkb:Q541Z1|uniprotkb:Q96D04|ensembl:ENSP00000497160	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ei2be_human(display_long)|uniprotkb:EIF2B5(gene name)|psi-mi:EIF2B5(display_short)|uniprotkb:EIF2BE(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003898.2|ensembl:ENSG00000145191(gene)|ensembl:ENST00000648915(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007568"(aging)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042552"(myelination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:3JUI|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:158kR+Yjj/jXya10LiK3Xp0Fa5w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NV70	intact:EBI-1257113	intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P04083	intact:EBI-1257113	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P09496-2	intact:EBI-1257113	intact:EBI-4401010|ensembl:ENSP00000242284	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p09496-2(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1171169(isoform-parent)|ensembl:ENSG00000122705(gene)|ensembl:ENST00000345519(transcript)|uniprotkb:P09496-2(isoform-parent)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0k8RkZBtJhE5Dd3a/4GBwaTT1gw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P01111	intact:EBI-1257113	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51153	intact:EBI-1257113	intact:EBI-1780121|uniprotkb:Q5U0A6|uniprotkb:Q6GPG6|uniprotkb:Q96GU4|uniprotkb:A8K6B5|uniprotkb:D3DV67|ensembl:ENSP00000357564	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab13_human(display_long)|uniprotkb:RAB13(gene name)|psi-mi:RAB13(display_short)|uniprotkb:GIG4(orf name)|uniprotkb:Cell growth-inhibiting gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002861.1|refseq:NP_001258967.1|dip:DIP-40268N|ensembl:ENSG00000143545(gene)|ensembl:ENST00000368575(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51153|reactome:R-HSA-1445148|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XopTW/3AqUPyTi66Nf0HYlkD6Fw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6N9	intact:EBI-1257113	intact:EBI-954308|ensembl:ENSP00000317018|uniprotkb:Q96B29|uniprotkb:Q9UM04|uniprotkb:Q9UM17|uniprotkb:Q9UPC3|uniprotkb:A8K423|uniprotkb:Q7RTU8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ush1c_human(display_long)|uniprotkb:Usher syndrome type-1C protein(gene name synonym)|uniprotkb:Autoimmune enteropathy-related antigen AIE-75(gene name synonym)|uniprotkb:Antigen NY-CO-38/NY-CO-37(gene name synonym)|uniprotkb:Protein PDZ-73(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-3(gene name synonym)|uniprotkb:USH1C(gene name)|psi-mi:USH1C(display_short)|uniprotkb:AIE75(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030507"(spectrin binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0034622"|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:1904970"(brush border assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030237|interpro:IPR036034|rcsb pdb:1X5N|rcsb pdb:2KBQ|rcsb pdb:2KBR|rcsb pdb:2KBS|rcsb pdb:2LSR|rcsb pdb:3K1R|rcsb pdb:5F3X|rcsb pdb:5MV8|rcsb pdb:5MV9|rcsb pdb:5XBF|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSG00000006611(gene)|ensembl:ENST00000318024(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|refseq:NP_005700.2|refseq:NP_001284693.1|refseq:NP_710142.1|dip:DIP-41473N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FZD03Nq9dvV88xyKOBIgshO3Fvg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63000	intact:EBI-1257113	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5K8	intact:EBI-1257113	intact:EBI-2684998|uniprotkb:Q9Y688|uniprotkb:B2RE33|ensembl:ENSP00000216442|ensembl:ENSP00000451167	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatd_human(display_long)|uniprotkb:ATP6M(gene name synonym)|uniprotkb:VATD(gene name synonym)|uniprotkb:V-ATPase 28 kDa accessory protein(gene name synonym)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)|uniprotkb:ATP6V1D(gene name)|psi-mi:ATP6V1D(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057078.1|ensembl:ENSG00000100554(gene)|ensembl:ENST00000216442(transcript)|ensembl:ENST00000554087(transcript)|go:"GO:0005765"(lysosomal membrane)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|mint:Q9Y5K8|rcsb pdb:6WLZ|go:"GO:0005829"(cytosol)|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UBGjCKLxcq9lkUY/Vh6+Kr2i+uk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95782	intact:EBI-1257113	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8N5K1	intact:EBI-1257113	intact:EBI-1045797|uniprotkb:Q7Z3D5|ensembl:ENSP00000273986	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cisd2_human(display_long)|uniprotkb:CDGSH2(gene name synonym)|uniprotkb:ERIS(gene name synonym)|uniprotkb:ZCD2(gene name synonym)|uniprotkb:Endoplasmic reticulum intermembrane small protein(gene name synonym)|uniprotkb:MitoNEET-related 1 protein(gene name synonym)|uniprotkb:CISD2(gene name)|psi-mi:CISD2(display_short)|uniprotkb:Nutrient-deprivation autophagy factor-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008389.1|ensembl:ENSG00000145354(gene)|ensembl:ENST00000273986(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR018967|interpro:IPR019610|interpro:IPR042216|rcsb pdb:3FNV|rcsb pdb:4OO7|rcsb pdb:4OOA|go:"GO:0005741"(mitochondrial outer membrane)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YxickLtFNLILnuUDAXl1QqFadD09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BM9	intact:EBI-1257113	intact:EBI-4401082|uniprotkb:B3KXD0|ensembl:ENSP00000272217	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl8a_human(display_long)|uniprotkb:ARL8A(gene name)|psi-mi:ARL8A(display_short)|uniprotkb:ARL10B(gene name synonym)|uniprotkb:GIE2(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 10B(gene name synonym)|uniprotkb:Novel small G protein indispensable for equal chromosome segregation 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_620150.1|refseq:NP_001243058.1|ensembl:ENSG00000143862(gene)|ensembl:ENST00000272217(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045202"(synapse)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044154|rcsb pdb:1ZD9|rcsb pdb:2H18|rcsb pdb:4ILE|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DZU9T4htQdahFZ8f2k2Fc4JqqZc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96H20	intact:EBI-1257113	intact:EBI-747719|uniprotkb:Q8IXY3|uniprotkb:Q9UN50|ensembl:ENSP00000421380	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snf8_human(display_long)|uniprotkb:ELL-associated protein of 30 kDa(gene name synonym)|uniprotkb:SNF8(gene name)|psi-mi:SNF8(display_short)|uniprotkb:EAP30(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009172.2|refseq:NP_001304121.1|refseq:NP_001304122.1|refseq:NP_001304123.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016247"(channel regulator activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903772"(regulation of viral budding via host ESCRT complex)|interpro:IPR016689(ESCRT-2 complex, Snf8)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040608|mint:Q96H20|rcsb pdb:2ZME|rcsb pdb:3CUQ|reactome:R-HSA-917729|reactome:R-HSA-9610379|ensembl:ENSG00000159210(gene)|ensembl:ENST00000502492(transcript)|go:"GO:0000814"(ESCRT II complex)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FyjlBpOt9okBFV8Z+g8YLUeyCm49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NYT0	intact:EBI-1257113	intact:EBI-4289944|uniprotkb:Q96JT0|ensembl:ENSP00000216446	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:plek2_human(display_long)|uniprotkb:PLEK2(gene name)|psi-mi:PLEK2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100558(gene)|ensembl:ENST00000216446(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120034"(positive regulation of plasma membrane bounded cell projection assembly)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037369|rcsb pdb:1X1G|refseq:NP_057529.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h2kivk7G2Zf237nX6S22dhu1uec9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O76027	intact:EBI-1257113	intact:EBI-720960|ensembl:ENSP00000357943|uniprotkb:Q5SZF1|uniprotkb:Q6FI55|uniprotkb:Q9BS00|uniprotkb:Q9HBJ6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa9_human(display_long)|uniprotkb:Annexin-9(gene name synonym)|uniprotkb:Annexin-31(gene name synonym)|uniprotkb:Annexin XXXI(gene name synonym)|uniprotkb:Pemphaxin(gene name synonym)|uniprotkb:ANXA9(gene name)|psi-mi:ANXA9(display_short)|uniprotkb:ANX31(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143412(gene)|ensembl:ENST00000368947(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0045202"(synapse)|refseq:NP_003559.2|go:"GO:0046790"(virion binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001464(Annexin)|interpro:IPR009116(Annexin, type XXXI)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2fjaN8KglkfcnlwfB/hEy3yt8ag9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40222	intact:EBI-1257113	intact:EBI-359793|uniprotkb:Q5TFJ6|uniprotkb:Q66K62|uniprotkb:Q86T54|uniprotkb:Q86T85|uniprotkb:Q86T86|uniprotkb:Q86Y86|uniprotkb:Q86YW3|uniprotkb:Q8N2Y3|uniprotkb:D3DPP6|ensembl:ENSP00000362711|ensembl:ENSP00000362712	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:txlna_human(display_long)|uniprotkb:TXLNA(gene name)|psi-mi:TXLNA(display_short)|uniprotkb:TXLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_787048.1|ensembl:ENSG00000084652(gene)|ensembl:ENST00000373609(transcript)|ensembl:ENST00000373610(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0042113"(B cell activation)|interpro:IPR026183|reactome:R-HSA-449836|refseq:XP_016856051.1|dip:DIP-27612N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m6McBNTQ5VY4RNUY6PyYTj97YUk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14651	intact:EBI-1257113	intact:EBI-1047196|uniprotkb:D3DNG3|uniprotkb:A8K2Q1|uniprotkb:Q8NEG6|ensembl:ENSP00000336831|ensembl:ENSP00000387890|ensembl:ENSP00000418700	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:plsi_human(display_long)|uniprotkb:Intestine-specific plastin(gene name synonym)|uniprotkb:PLS1(gene name)|psi-mi:PLS1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR018247|interpro:IPR011992(EF-Hand type)|interpro:IPR030235|interpro:IPR036872|interpro:IPR039959|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_001138791.1|refseq:NP_001165783.1|refseq:NP_002661.2|refseq:XP_011511202.1|refseq:XP_011511203.1|refseq:XP_011511205.1|ensembl:ENSG00000120756(gene)|ensembl:ENST00000337777(transcript)|ensembl:ENST00000457734(transcript)|ensembl:ENST00000497002(transcript)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005903"(brush border)|go:"GO:0032420"(stereocilium)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051639"(actin filament network formation)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060121"(vestibular receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902896"(terminal web assembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_006713723.1|refseq:XP_016862115.1|refseq:XP_016862116.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jDBbZOh8WmNZbAhnOmxcqb6fGvc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P23528	intact:EBI-1257113	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99623	intact:EBI-1257113	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NVA2	intact:EBI-1257113	intact:EBI-957999|uniprotkb:Q7L4N1|uniprotkb:Q96SP1|uniprotkb:B7Z7Z6|uniprotkb:Q4W5G1|uniprotkb:Q9UFY9|ensembl:ENSP00000264893|uniprotkb:E9KL32	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sep11_human(display_long)|uniprotkb:SEPTIN11(gene name)|psi-mi:SEPTIN11(display_short)|uniprotkb:SEPT11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060713.1|ensembl:ENSG00000138758(gene)|ensembl:ENST00000264893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:6UPQ|refseq:NP_001293076.1|refseq:XP_016863889.1|dip:DIP-36161N	-	-	crc64:D467F1F315FFD028	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2dJm0WBfPs71hp1nBoMeGF/DR2s9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P10321	intact:EBI-1257113	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51148	intact:EBI-1257113	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50395	intact:EBI-1257113	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H223	intact:EBI-1257113	intact:EBI-1050573|uniprotkb:Q9HAR1|uniprotkb:Q9NZN2|ensembl:ENSP00000220325	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ehd4_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated protein 10/11(gene name synonym)|uniprotkb:EHD4(gene name)|psi-mi:EHD4(display_short)|uniprotkb:HCA10(gene name synonym)|uniprotkb:HCA11(gene name synonym)|uniprotkb:FKSG7(orf name)|uniprotkb:PAST4(gene name synonym)|uniprotkb:PAST homolog 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_644670.1|ensembl:ENSG00000103966(gene)|ensembl:ENST00000220325(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029952|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H223	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WtFn0GamyqosWQvcBXdhbtjJ3Fw9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61619	intact:EBI-1257113	intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46940	intact:EBI-1257113	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q95IZ1	intact:EBI-1257113	intact:EBI-4400755	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q95iz1_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR036179|interpro:IPR037055	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JQOAjX8YkQqtMaWzwW+VW0pfV8M9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q59HA3	intact:EBI-1257113	intact:EBI-4400728	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q59ha3_human(display_long)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR000048(IQ calmodulin-binding region)|refseq:NP_001272390.1|refseq:NP_001272391.1|refseq:NP_006624.2|refseq:NP_001272389.1|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR023152|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR001202(WW/Rsp5/WWP)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:U72wuh9ICKIg6F0Fq3gSsRn0Adg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43592	intact:EBI-1257113	intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q03519	intact:EBI-1257113	intact:EBI-780781|uniprotkb:Q9UQ83|uniprotkb:O95410|uniprotkb:B0V2J8|uniprotkb:Q53FI6|uniprotkb:Q5HY71|uniprotkb:Q96PT8|ensembl:ENSP00000364032|ensembl:ENSP00000372599|ensembl:ENSP00000372726|ensembl:ENSP00000390013|ensembl:ENSP00000394101	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tap2_human(display_long)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Peptide transporter TAP2(gene name synonym)|uniprotkb:Peptide supply factor 2(gene name synonym)|uniprotkb:Peptide transporter PSF2(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 2(gene name synonym)|uniprotkb:TAP2(gene name)|psi-mi:TAP2(display_short)|uniprotkb:ABCB3(gene name synonym)|uniprotkb:PSF2(gene name synonym)|uniprotkb:RING11(gene name synonym)|uniprotkb:Y1(gene name synonym)|uniprotkb:Really interesting new gene 11 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276972.1|refseq:NP_000535.3|refseq:NP_061313.2|dip:DIP-322N|ensembl:ENSG00000204267(gene)|ensembl:ENSG00000206235(gene)|ensembl:ENSG00000206299(gene)|ensembl:ENSG00000228582(gene)|ensembl:ENSG00000237599(gene)|ensembl:ENST00000374897(transcript)|ensembl:ENST00000383118(transcript)|ensembl:ENST00000383239(transcript)|ensembl:ENST00000419142(transcript)|ensembl:ENST00000443713(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03519|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:w7pDqjoSODoB8qMag1ycxcapvQ09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00610	intact:EBI-1257113	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11234	intact:EBI-1257113	intact:EBI-752162|uniprotkb:Q53T32|intact:EBI-4324693|uniprotkb:B4E040|uniprotkb:Q6ZS74|ensembl:ENSP00000272519|ensembl:ENSP00000414224	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ralb_human(display_long)|uniprotkb:RALB(gene name)|psi-mi:RALB(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002872.1|refseq:XP_016860111.1|refseq:XP_005263781.1|refseq:XP_005263784.1|refseq:XP_005263785.1|refseq:XP_005263786.1|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:2KE5|rcsb pdb:2KWI|rcsb pdb:6ZQT|rcsb pdb:6ZRN|reactome:R-HSA-171007|ensembl:ENSG00000144118(gene)|ensembl:ENST00000272519(transcript)|ensembl:ENST00000420510(transcript)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vw59HFSN8liew1tYF7x9fgdeFCU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P33176	intact:EBI-1257113	intact:EBI-355878|uniprotkb:A0AVB2|uniprotkb:Q5VZ85|ensembl:ENSP00000307078	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kinh_human(display_long)|uniprotkb:KIF5B(gene name)|psi-mi:KIF5B(display_short)|uniprotkb:KNS(gene name synonym)|uniprotkb:KNS1(gene name synonym)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004512.1|ensembl:ENSG00000170759(gene)|ensembl:ENST00000302418(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33176|rcsb pdb:1BG2|rcsb pdb:1MKJ|rcsb pdb:2P4N|rcsb pdb:3J8X|rcsb pdb:3J8Y|rcsb pdb:4HNA|rcsb pdb:4LNU|rcsb pdb:5LT0|rcsb pdb:5LT1|rcsb pdb:5LT2|rcsb pdb:5LT3|rcsb pdb:5LT4|rcsb pdb:6OJQ|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-29244N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2UUVZBn5EAd0xBA5IZDPWHX9i7U9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P07355	intact:EBI-1257113	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y490	intact:EBI-1257113	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q03518	intact:EBI-1257113	intact:EBI-747259|uniprotkb:Q16149|intact:EBI-780739|uniprotkb:Q96CP4|ensembl:ENSP00000346206|ensembl:ENSP00000372722|ensembl:ENSP00000401149|ensembl:ENSP00000402316|ensembl:ENSP00000405356|ensembl:ENSP00000413080|ensembl:ENSP00000415660	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tap1_human(display_long)|uniprotkb:ABCB2(gene name synonym)|uniprotkb:PSF1(gene name synonym)|uniprotkb:RING4(gene name synonym)|uniprotkb:Y3(gene name synonym)|uniprotkb:TAP1(gene name)|psi-mi:TAP1(display_short)|uniprotkb:Peptide transporter TAP1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 2(gene name synonym)|uniprotkb:Peptide supply factor 1(gene name synonym)|uniprotkb:Peptide transporter PSF1(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 1(gene name synonym)|uniprotkb:Really interesting new gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000584.2|refseq:NP_001278951.1|ensembl:ENSG00000168394(gene)|ensembl:ENSG00000206297(gene)|ensembl:ENSG00000224212(gene)|ensembl:ENSG00000226173(gene)|ensembl:ENSG00000227816(gene)|ensembl:ENSG00000230705(gene)|ensembl:ENSG00000232367(gene)|ensembl:ENST00000354258(transcript)|ensembl:ENST00000383235(transcript)|ensembl:ENST00000414467(transcript)|ensembl:ENST00000418205(transcript)|ensembl:ENST00000424897(transcript)|ensembl:ENST00000439781(transcript)|ensembl:ENST00000440894(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043531"(ADP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR013306(ABC transporter, B3)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03518|rcsb pdb:1JJ7|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170|dip:DIP-35626N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fkl1VU1VSl8sEjURg8kRj0joZlY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O94905	intact:EBI-1257113	intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11233	intact:EBI-1257113	intact:EBI-1036803|uniprotkb:A4D1W3|ensembl:ENSP00000005257	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rala_human(display_long)|uniprotkb:RAL(gene name synonym)|uniprotkb:RALA(gene name)|psi-mi:RALA(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005393.2|refseq:XP_006715825.1|go:"GO:0019003"(GDP binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051665"(membrane raft localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090543"(Flemming body)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:1UAD|rcsb pdb:1ZC3|rcsb pdb:1ZC4|rcsb pdb:2A78|mint:P11233|rcsb pdb:2A9K|rcsb pdb:2BOV|rcsb pdb:6P0I|rcsb pdb:6P0J|rcsb pdb:6P0K|rcsb pdb:6P0L|rcsb pdb:6P0M|rcsb pdb:6P0N|rcsb pdb:6P0O|reactome:R-HSA-1445148|reactome:R-HSA-171007|reactome:R-HSA-8950505|ensembl:ENSG00000006451(gene)|ensembl:ENST00000005257(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|refseq:XP_011513768.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:41WF1UoYnYZvwC0OPpYwCEqIg2E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43707	intact:EBI-1257113	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49755	intact:EBI-1257113	intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WVM8	intact:EBI-1257113	intact:EBI-722569|uniprotkb:O60754|uniprotkb:O94990|uniprotkb:Q7Z529|uniprotkb:Q9BZI3|uniprotkb:Q9UNL3|uniprotkb:Q9Y6A8|uniprotkb:A8K2Z5|uniprotkb:B7Z4U7|uniprotkb:B7Z594|ensembl:ENSP00000390783	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scfd1_human(display_long)|uniprotkb:Syntaxin-binding protein 1-like 2(gene name synonym)|uniprotkb:SLY1 homolog(gene name synonym)|uniprotkb:FKSG23(orf name)|uniprotkb:SCFD1(gene name)|psi-mi:SCFD1(display_short)|uniprotkb:KIAA0917(gene name synonym)|uniprotkb:STXBP1L2(gene name synonym)|uniprotkb:C14orf163(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001269961.1|refseq:NP_057190.2|refseq:NP_001244305.1|refseq:NP_878255.1|mint:Q8WVM8|reactome:R-HSA-204005|reactome:R-HSA-8980692|ensembl:ENSG00000092108(gene)|ensembl:ENST00000458591(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1901998"(toxin transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:7cD2Z6zhuKLCd3ERB+pVNRdVexY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99653	intact:EBI-1257113	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q01082	intact:EBI-1257113	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q01082-3	intact:EBI-1257113	intact:EBI-4400743|ensembl:ENSP00000334156	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q01082-3(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-351561(isoform-parent)|ensembl:ENSG00000115306(gene)|ensembl:ENST00000333896(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 14.	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:P5k7h1BWJDBzbF8V0SaJp8DUcoQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14204	intact:EBI-1257113	intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJZ1	intact:EBI-1257113	intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49736	intact:EBI-1257113	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15149-4	intact:EBI-1257113	intact:EBI-4400800|ensembl:ENSP00000344848	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q15149-4(display_long)|uniprotkb:Plectin-11(isoform synonym)|uniprotkb:1a(isoform synonym)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-297903(isoform-parent)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000345136(transcript)	-	-	isoform-comment:"Contains a phosphotyrosine at position 26 (By similarity). Contains a phosphoserine at position 20. Contains a phosphoserine at position 21."	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Mab4pIGzal4qzdp3T3IZXT5ET289606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96A65	intact:EBI-1257113	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96QK1	intact:EBI-1257113	intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EXkMduDQKNCdp876vGF5vna9t389606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4M9	intact:EBI-1257113	intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75369	intact:EBI-1257113	intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P78527	intact:EBI-1257113	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P09525	intact:EBI-1257113	intact:EBI-2556852|uniprotkb:B4DDF9|uniprotkb:Q9BWK1|uniprotkb:Q96F33|ensembl:ENSP00000377833	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa4_human(display_long)|uniprotkb:ANX4(gene name synonym)|uniprotkb:Annexin-4(gene name synonym)|uniprotkb:Annexin IV(gene name synonym)|uniprotkb:Lipocortin IV(gene name synonym)|uniprotkb:Endonexin I(gene name synonym)|uniprotkb:Chromobindin-4(gene name synonym)|uniprotkb:Protein II(gene name synonym)|uniprotkb:P32.5(gene name synonym)|uniprotkb:Placental anticoagulant protein II(gene name synonym)|uniprotkb:PP4-X(gene name synonym)|uniprotkb:35-beta calcimedin(gene name synonym)|uniprotkb:Carbohydrate-binding protein p33/p41(gene name synonym)|uniprotkb:ANXA4(gene name)|psi-mi:ANXA4(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001144.1|ensembl:ENSG00000196975(gene)|ensembl:ENST00000394295(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0012506"(vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR002391(Annexin, type IV)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|rcsb pdb:2ZOC|refseq:NP_001307627.1|refseq:NP_001307629.1|refseq:NP_001307631.1|refseq:XP_016859432.1|refseq:XP_016859433.1	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9FM1bXFxch8Srj1njfDiNXtowDU9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WWI1-3	intact:EBI-1257113	intact:EBI-4400717|ensembl:ENSP00000342112	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UIA9	intact:EBI-1257113	intact:EBI-286668|uniprotkb:O94846|uniprotkb:Q6PJK9|uniprotkb:Q8NEK7|ensembl:ENSP00000252512	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpo7_human(display_long)|uniprotkb:Ran-binding protein 16(gene name synonym)|uniprotkb:XPO7(gene name)|psi-mi:XPO7(display_short)|uniprotkb:KIAA0745(gene name synonym)|uniprotkb:RANBP16(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055839.3|ensembl:ENSG00000130227(gene)|ensembl:ENST00000252512(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040021|interpro:IPR044189|mint:Q9UIA9	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:v+DQUTgId55XuRlCPZ4tq7fIing9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61106	intact:EBI-1257113	intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75396	intact:EBI-1257113	intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DRKtD169T9eYZ2kFufLapidvcKs9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35232	intact:EBI-1257113	intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75340	intact:EBI-1257113	intact:EBI-352915|uniprotkb:E7ESR3|uniprotkb:Q5TZS0|uniprotkb:B2RD16|uniprotkb:Q2YDC2|ensembl:ENSP00000264933	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pdcd6_human(display_long)|uniprotkb:PDCD6(gene name)|psi-mi:PDCD6(display_short)|uniprotkb:ALG2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O75340|rcsb pdb:2ZN8|rcsb pdb:2ZN9|rcsb pdb:2ZND|rcsb pdb:2ZNE|rcsb pdb:2ZRS|rcsb pdb:2ZRT|rcsb pdb:3AAJ|rcsb pdb:3AAK|rcsb pdb:3WXA|rcsb pdb:5GQQ|go:"GO:0046983"(protein dimerization activity)|refseq:NP_037364.1|refseq:NP_001254485.1|refseq:NP_001254486.1|refseq:NP_001254487.1|refseq:NP_001254488.1|ensembl:ENSG00000249915(gene)|ensembl:ENST00000264933(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|dip:DIP-33217N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qbNAx73X9TJNr0MVNcy7Q9qN3Hg9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P37802	intact:EBI-1257113	intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13263	intact:EBI-1257113	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHD8	intact:EBI-1257113	intact:EBI-851542|uniprotkb:Q96QF3|uniprotkb:Q96QF4|uniprotkb:Q96QF5|uniprotkb:Q9HA04|uniprotkb:Q9UG40|uniprotkb:Q9Y5W4|uniprotkb:A8K2V3|uniprotkb:B3KPM0|uniprotkb:B4DTL9|uniprotkb:B4E0N2|uniprotkb:B4E274|uniprotkb:B7Z654|ensembl:ENSP00000391249	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept9_human(display_long)|uniprotkb:SEPTIN9(gene name)|psi-mi:SEPTIN9(display_short)|uniprotkb:KIAA0991(gene name synonym)|uniprotkb:MLL septin-like fusion protein MSF-A(gene name synonym)|uniprotkb:MSF(gene name synonym)|uniprotkb:Ovarian/Breast septin(gene name synonym)|uniprotkb:SEPT9(gene name synonym)|uniprotkb:Septin D1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006721706.1|refseq:XP_006721707.1|refseq:NP_001106963.1|refseq:NP_001106964.1|refseq:NP_001106965.1|refseq:NP_001106966.1|refseq:NP_001106967.1|refseq:NP_001106968.1|refseq:NP_006631.2|refseq:XP_016879520.1|refseq:XP_016879521.1|refseq:NP_001280624.1|refseq:NP_001280625.1|refseq:NP_001280626.1|refseq:NP_001280627.1|refseq:XP_011522509.1|refseq:XP_011522510.1|refseq:XP_005257019.1|dip:DIP-36697N|ensembl:ENSG00000184640(gene)|ensembl:ENST00000427177(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030645|mint:Q9UHD8|rcsb pdb:4YQF|rcsb pdb:5CYO|rcsb pdb:5CYP	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YzUn6hS5tAX/U+SJ8YzqzWW/dQI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P18085	intact:EBI-1257113	intact:EBI-1237085|ensembl:ENSP00000306010|uniprotkb:P21371|uniprotkb:B2R7J7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arf4_human(display_long)|uniprotkb:ARF4(gene name)|psi-mi:ARF4(display_short)|uniprotkb:ARF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168374(gene)|ensembl:ENST00000303436(transcript)|refseq:NP_001651.1|dip:DIP-38214N|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045176"(apical protein localization)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048678"(response to axon injury)|go:"GO:0060271"(cilium assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P18085|rcsb pdb:1Z6X|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AN3aBuSStAMrmkqq1HEDQtOiCy49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P38606	intact:EBI-1257113	intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15019	intact:EBI-1257113	intact:EBI-741220|intact:EBI-28986019|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENSP00000385172|uniprotkb:Q14132|uniprotkb:Q8IUK9|uniprotkb:Q96CB0|uniprotkb:B4DGE8|uniprotkb:Q53QU3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept2_human(display_long)|uniprotkb:SEPTIN2(gene name)|psi-mi:SEPTIN2(display_short)|uniprotkb:DIFF6(gene name synonym)|uniprotkb:KIAA0158(gene name synonym)|uniprotkb:NEDD5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)|uniprotkb:SEPT2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001269901.1|refseq:NP_001269902.1|ensembl:ENSG00000168385(gene)|ensembl:ENST00000360051(transcript)|ensembl:ENST00000391971(transcript)|ensembl:ENST00000391973(transcript)|ensembl:ENST00000402092(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q15019|rcsb pdb:2QA5|rcsb pdb:2QAG|rcsb pdb:2QNR|rcsb pdb:6UPA|rcsb pdb:6UPQ|rcsb pdb:6UPR|reactome:R-HSA-5620912|refseq:NP_001008491.1|refseq:NP_001008492.1|refseq:NP_004395.1|refseq:NP_006146.1|refseq:XP_016859694.1|refseq:XP_016859695.1|refseq:NP_001307958.1|refseq:NP_001307959.1|refseq:NP_001307960.1|refseq:NP_001307961.1|refseq:NP_001307962.1|refseq:NP_001307963.1|refseq:NP_001307964.1|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENST00000401990|ensembl:ENSP00000385109|ensembl:ENSP00000385172|ensembl:ENST00000616972|ensembl:ENSP00000479861|dip:DIP-38220N	-	-	crc64:12CCBBE30806F92F	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H0Us8GtPe2XuXlOYXC0DX79kB/49606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00186	intact:EBI-1257113	intact:EBI-2803005|uniprotkb:Q86YJ3|uniprotkb:A8K5K7|uniprotkb:Q9UPD7|uniprotkb:A8K269|intact:EBI-3255674|uniprotkb:Q53FW1|ensembl:ENSP00000359025	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stxb3_human(display_long)|uniprotkb:Platelet Sec1 protein(gene name synonym)|uniprotkb:Protein unc-18 homolog 3(gene name synonym)|uniprotkb:Protein unc-18 homolog C(gene name synonym)|uniprotkb:STXBP3(gene name)|psi-mi:STXBP3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4400799|pride:19140|imex:IM-15829-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009200.2|ensembl:ENSG00000116266(gene)|ensembl:ENST00000370008(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032868"(response to insulin)|go:"GO:0042581"(specific granule)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070820"(tertiary granule)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|reactome:R-HSA-114516|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iDBy0rQnIRdaV5yej86+OU1xcqk9606	intact-crc:D0D8BD26DFB2C29A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00978	intact:EBI-1257113	intact:EBI-626526|ensembl:ENSP00000380073|ensembl:ENSP00000494792|uniprotkb:D3DS61	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:irf9_human(display_long)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:IRF9(gene name)|psi-mi:IRF9(display_short)|uniprotkb:ISGF3G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000213928(gene)|ensembl:ENSG00000285048(gene)|ensembl:ENST00000396864(transcript)|ensembl:ENST00000646071(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-877300|reactome:R-HSA-909733|refseq:NP_006075.3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8FfmT/MiSW3eIxCL2ip5OSXyKyE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H900	intact:EBI-1257113	intact:EBI-1001239|uniprotkb:Q6N049|uniprotkb:Q96SY7|uniprotkb:Q9NWG7|uniprotkb:Q8N404|uniprotkb:B3KVB8|ensembl:ENSP00000311429	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zwilc_human(display_long)|uniprotkb:ZWILCH(gene name)|psi-mi:ZWILCH(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060445.3|refseq:NP_001274750.1|refseq:NP_001274751.1|refseq:NP_001274752.1|dip:DIP-36478N|ensembl:ENSG00000174442(gene)|ensembl:ENST00000307897(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005829"(cytosol)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|go:"GO:1990423"(RZZ complex)|interpro:IPR018630|rcsb pdb:3IF8|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pIk5I4Y9Qk7AxO0KhWURdlvUu/Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HBM1	intact:EBI-1257113	intact:EBI-999909|ensembl:ENSP00000282074|ensembl:ENSP00000481354|ensembl:ENSP00000483050|uniprotkb:D3DPC0|uniprotkb:A8K4X8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:spc25_human(display_long)|uniprotkb:AD024(orf name)|uniprotkb:SPC25(gene name)|psi-mi:SPC25(display_short)|uniprotkb:SPBC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065726.1|ensembl:ENSG00000277909(gene)|ensembl:ENST00000282074(transcript)|ensembl:ENST00000611144(transcript)|ensembl:ENST00000616584(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0051301"(cell division)|interpro:IPR013255(Kinetochore-Ndc80 subunit Spc25)|mint:Q9HBM1|rcsb pdb:2VE7|rcsb pdb:3IZ0|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSG00000152253(gene)|dip:DIP-35753N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qR1LJPKAJwXtOdzKs4Zg0PqJrBM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50748	intact:EBI-1257113	intact:EBI-1001245|uniprotkb:B3KSG2|uniprotkb:A7E2C4|ensembl:ENSP00000328236	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kntc1_human(display_long)|uniprotkb:Rough deal homolog(gene name synonym)|uniprotkb:KNTC1(gene name)|psi-mi:KNTC1(display_short)|uniprotkb:KIAA0166(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055523.1|ensembl:ENSG00000184445(gene)|ensembl:ENST00000333479(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1990423"(RZZ complex)|interpro:IPR019527|interpro:IPR036322|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_006719769.1|dip:DIP-36479N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Fzk1xgK9pVFUAlEHLG3L35X0scU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43264	intact:EBI-1257113	intact:EBI-1001217|ensembl:ENSP00000200135|uniprotkb:A1A528	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zw10_human(display_long)|uniprotkb:ZW10(gene name)|psi-mi:ZW10(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004715.1|ensembl:ENSG00000086827(gene)|ensembl:ENST00000200135(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070939"(Dsl1/NZR complex)|go:"GO:1990423"(RZZ complex)|interpro:IPR009361(Centromerekinetochore Zw10)|mint:O43264|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-36471N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yqOV+ZYOLEPClJbYtPp9Jvlhyvc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62070	intact:EBI-1257113	intact:EBI-491037|uniprotkb:P17082|uniprotkb:B2R9Z3|uniprotkb:B7Z6C4|uniprotkb:B7Z7H6|ensembl:ENSP00000256196|uniprotkb:B7Z5Z2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rras2_human(display_long)|uniprotkb:Ras-like protein TC21(gene name synonym)|uniprotkb:Teratocarcinoma oncogene(gene name synonym)|uniprotkb:RRAS2(gene name)|psi-mi:RRAS2(display_short)|uniprotkb:TC21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036382.2|refseq:NP_001096139.1|refseq:NP_001170786.1|refseq:NP_001170785.1|ensembl:ENSG00000133818(gene)|ensembl:ENST00000256196(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:2ERY|reactome:R-HSA-9696273	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P10301	intact:EBI-1257113	intact:EBI-968703|ensembl:ENSP00000246792|uniprotkb:Q6FH12	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rras_human(display_long)|uniprotkb:RRAS(gene name)|psi-mi:RRAS(display_short)|uniprotkb:p23(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000126458(gene)|ensembl:ENST00000246792(transcript)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:2FN4|reactome:R-HSA-399955|reactome:R-HSA-416550|refseq:NP_006261.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dt5bYEie4ALGX+PSJy5xMMCiIh09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q08AM6	intact:EBI-1257113	intact:EBI-2107455|uniprotkb:Q13174|uniprotkb:Q6IA12|uniprotkb:Q7L4Y1|uniprotkb:Q9BW96|uniprotkb:Q9H6V6|uniprotkb:B3KPJ5|uniprotkb:B3KSM8|ensembl:ENSP00000261776	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vac14_human(display_long)|uniprotkb:Tax1-binding protein 2(gene name synonym)|uniprotkb:VAC14(gene name)|psi-mi:VAC14(display_short)|uniprotkb:TAX1BP2(gene name synonym)|uniprotkb:TRX(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060522.3|ensembl:ENSG00000103043(gene)|ensembl:ENST00000261776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000306"(extrinsic component of vacuolar membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070772"(PAS complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021841|interpro:IPR026825|mint:Q08AM6|rcsb pdb:7K1Y|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S9syIZ/DKHNbOM0Nw9oZP5F+AvA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IXI1	intact:EBI-1257113	intact:EBI-1396563|uniprotkb:Q8NF53|uniprotkb:Q96C13|uniprotkb:Q96S17|uniprotkb:Q9BT60|uniprotkb:Q9H7M8|uniprotkb:A2IDC2|ensembl:ENSP00000321971	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:miro2_human(display_long)|uniprotkb:RHOT2(gene name)|psi-mi:RHOT2(display_short)|uniprotkb:ARHT2(gene name synonym)|uniprotkb:C16orf39(gene name synonym)|uniprotkb:Ras homolog gene family member T2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_620124.1|ensembl:ENSG00000140983(gene)|ensembl:ENST00000315082(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|mint:Q8IXI1|rcsb pdb:5KUT|reactome:R-HSA-9013419	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E+WoN8aoND+U/YkLBUTecrNbDXg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62834	intact:EBI-1257113	intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IXI2	intact:EBI-1257113	intact:EBI-1396430|uniprotkb:A4FVB6|uniprotkb:Q6NUR3|uniprotkb:Q6P9F8|uniprotkb:Q6PJG1|uniprotkb:Q6YMW8|uniprotkb:Q86UB0|uniprotkb:Q8IW28|uniprotkb:Q8IXJ7|uniprotkb:Q9H067|uniprotkb:Q9H9N8|uniprotkb:Q9NUZ2|uniprotkb:A6NFV0|uniprotkb:B4DG48|uniprotkb:J9JIH9|ensembl:ENSP00000334724	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:miro1_human(display_long)|uniprotkb:Ras homolog gene family member T1(gene name synonym)|uniprotkb:Rac-GTP-binding protein-like protein(gene name synonym)|uniprotkb:RHOT1(gene name)|psi-mi:RHOT1(display_short)|uniprotkb:ARHT1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028738.1|refseq:NP_001028740.1|refseq:NP_060777.3|refseq:NP_001028739.2|refseq:NP_001275683.1|refseq:NP_001275684.1|refseq:NP_001275687.1|dip:DIP-39114N|ensembl:ENSG00000126858(gene)|ensembl:ENST00000333942(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0034640"(establishment of mitochondrion localization by microtubule attachment)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|interpro:IPR029506|mint:Q8IXI2|rcsb pdb:5KSO|rcsb pdb:5KSP|rcsb pdb:5KSY|rcsb pdb:5KSZ|rcsb pdb:5KTY|rcsb pdb:5KU1|rcsb pdb:6D71|reactome:R-HSA-5689880|reactome:R-HSA-9013425	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gA6A8bgSwshvMwCO0cG66h+wwIY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NZM1	intact:EBI-1257113	intact:EBI-1994363|uniprotkb:Q5VWW2|uniprotkb:Q5VWW3|uniprotkb:Q5VWW4|uniprotkb:Q5VWW5|uniprotkb:Q7Z642|uniprotkb:Q8IWH0|uniprotkb:Q9HBU3|uniprotkb:Q9NZM0|uniprotkb:Q9ULL3|uniprotkb:Q9Y4U4|uniprotkb:B3KQN5|ensembl:ENSP00000352208	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:myof_human(display_long)|uniprotkb:MYOF(gene name)|psi-mi:MYOF(display_short)|uniprotkb:KIAA1207(gene name synonym)|uniprotkb:FER1L3(gene name synonym)|uniprotkb:Fer-1-like protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_038479.1|refseq:NP_579899.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029999|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9NZM1|rcsb pdb:2DMH|rcsb pdb:2K2O|rcsb pdb:6EEL|ensembl:ENSG00000138119(gene)|ensembl:ENST00000359263(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006936"(muscle contraction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008015"(blood circulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0061025"(membrane fusion)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YbWzqcootZO0/w6OLRqxZEEAu9U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TD19	intact:EBI-1257113	intact:EBI-1044009|uniprotkb:Q52LK6|uniprotkb:Q8NCN0|uniprotkb:Q8TCY4|uniprotkb:Q9UPI4|uniprotkb:Q9Y6S4|uniprotkb:Q9Y6S5|uniprotkb:Q9Y6S6|intact:EBI-28978800|ensembl:ENSP00000238616	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nek9_human(display_long)|uniprotkb:NEK9(gene name)|psi-mi:NEK9(display_short)|uniprotkb:KIAA1995(gene name synonym)|uniprotkb:NEK8(gene name synonym)|uniprotkb:NERCC(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 9(gene name synonym)|uniprotkb:Nercc1 kinase(gene name synonym)|uniprotkb:NimA-related kinase 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_149107.4|ensembl:ENSG00000119638(gene)|ensembl:ENST00000238616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR042767|mint:Q8TD19|rcsb pdb:3ZKE|rcsb pdb:3ZKF|reactome:R-HSA-2980767|reactome:R-HSA-3301854|reactome:R-HSA-9648025|ensembl:ENSP00000238616|refseq:NP_001316166.1|refseq:NP_001316167.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nH92Hku490dDttw5Akug+NjXRNY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P29992	intact:EBI-1257113	intact:EBI-1171154|uniprotkb:O15109|uniprotkb:Q14350|uniprotkb:Q6IB00|ensembl:ENSP00000078429	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gna11_human(display_long)|uniprotkb:GNA11(gene name)|psi-mi:GNA11(display_short)|uniprotkb:GA11(gene name synonym)|uniprotkb:"Guanine nucleotide-binding protein G(y) subunit alpha"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002058.2|ensembl:ENSG00000088256(gene)|ensembl:ENST00000078429(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045634"(regulation of melanocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071467"(cellular response to pH)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P29992|rcsb pdb:6OIJ|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tb/5F5leSFWxmZySr0PzfPIbLAQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15264	intact:EBI-1257113	intact:EBI-2116951|uniprotkb:O14739|uniprotkb:O15124|uniprotkb:Q9UNU0|uniprotkb:Q6FI46|uniprotkb:Q5U4A5|ensembl:ENSP00000211287	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk13_human(display_long)|uniprotkb:MAPK13(gene name)|psi-mi:MAPK13(display_short)|uniprotkb:PRKM13(gene name synonym)|uniprotkb:SAPK4(gene name synonym)|uniprotkb:Stress-activated protein kinase 4(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002745.1|ensembl:ENSG00000156711(gene)|ensembl:ENST00000211287(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0072740"(cellular response to anisomycin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038785|rcsb pdb:3COI|rcsb pdb:4EYJ|rcsb pdb:4EYM|rcsb pdb:4MYG|rcsb pdb:4YNO|rcsb pdb:5EKN|rcsb pdb:5EKO|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-376172|reactome:R-HSA-4420097	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ESdnKcoE9u2TK5ixHx7fr2p3MFc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6PML9	intact:EBI-1257113	intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49137	intact:EBI-1257113	intact:EBI-993299|uniprotkb:Q8IYD6|uniprotkb:Q5SY30|uniprotkb:Q5SY41|ensembl:ENSP00000356070	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mapk2_human(display_long)|uniprotkb:MAPKAPK2(gene name)|psi-mi:MAPKAPK2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENSG00000162889(gene)|ensembl:ENST00000367103(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048839"(inner ear development)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:P49137|rcsb pdb:1KWP|rcsb pdb:1NXK|rcsb pdb:1NY3|rcsb pdb:2JBO|rcsb pdb:2JBP|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2OZA|rcsb pdb:2P3G|rcsb pdb:2PZY|rcsb pdb:3A2C|rcsb pdb:3FPM|rcsb pdb:3FYJ|rcsb pdb:3FYK|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450302|rcsb pdb:3GOK|rcsb pdb:3KA0|rcsb pdb:3KC3|rcsb pdb:3KGA|rcsb pdb:3M2W|rcsb pdb:3M42|rcsb pdb:3R2B|rcsb pdb:3R2Y|rcsb pdb:3R30|rcsb pdb:3WI6|rcsb pdb:4TYH|rcsb pdb:6T8X|rcsb pdb:6TCA|reactome:R-HSA-171007|reactome:R-HSA-199920|reactome:R-HSA-2142691|reactome:R-HSA-2559580|reactome:R-HSA-3371453|reactome:R-HSA-4420097|refseq:NP_004750.1|refseq:NP_116584.2|dip:DIP-35671N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iOzgeWqkVeJtasBfXoF50t7R2dE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42229	intact:EBI-1257113	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4A5	intact:EBI-1257113	intact:EBI-4403434|uniprotkb:B7Z6N3|uniprotkb:B1AN09|uniprotkb:Q9NVK0|ensembl:ENSP00000271732	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:glp3l_human(display_long)|uniprotkb:GOLPH3L(gene name)|psi-mi:GOLPH3L(display_short)|uniprotkb:GPP34R(gene name synonym)|uniprotkb:GPP34-related protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060648.2|ensembl:ENSG00000143457(gene)|ensembl:ENST00000271732(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A5	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E+0Ru85nv0KoO/LW0kZLN1vpbFc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14289	intact:EBI-1257113	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51812	intact:EBI-1257113	intact:EBI-1046616|ensembl:ENSP00000368884|uniprotkb:Q4VAP3|uniprotkb:Q59H26|uniprotkb:Q5JPK8|uniprotkb:Q7Z3Z7|uniprotkb:B2R9V4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ks6a3_human(display_long)|uniprotkb:Insulin-stimulated protein kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:MAPKAPK1B(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:RPS6KA3(gene name)|psi-mi:RPS6KA3(display_short)|uniprotkb:ISPK1(gene name synonym)|uniprotkb:RSK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045202"(synapse)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|ensembl:ENSG00000177189(gene)|ensembl:ENST00000379565(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_004577.1|interpro:IPR041905|interpro:IPR041906|mint:P51812|rcsb pdb:4D9T|rcsb pdb:4D9U|rcsb pdb:4JG6|rcsb pdb:4JG7|rcsb pdb:4JG8|rcsb pdb:4NUS|rcsb pdb:4NW5|rcsb pdb:4NW6|rcsb pdb:5D9K|rcsb pdb:5D9L|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|dip:DIP-38247N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zkX8NPvSEjVEap7TxboH2SKy9zg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TAE8	intact:EBI-1257113	intact:EBI-372506|uniprotkb:Q8IVM3|uniprotkb:Q8TE51|uniprotkb:Q969P9|uniprotkb:Q9BSM6|intact:EBI-28983431|ensembl:ENSP00000323065	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:g45ip_human(display_long)|uniprotkb:39S ribosomal protein L59, mitochondrial(gene name synonym)|uniprotkb:MRPL59(gene name synonym)|uniprotkb:CR6-interacting factor 1(gene name synonym)|uniprotkb:CKII beta-associating protein(gene name synonym)|uniprotkb:Papillomavirus L2-interacting nuclear protein 1(gene name synonym)|uniprotkb:p53-responsive gene 6 protein(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL64(gene name synonym)|uniprotkb:GADD45GIP1(gene name)|psi-mi:GADD45GIP1(display_short)|uniprotkb:PLINP1(gene name synonym)|uniprotkb:PRG6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_443082.2|ensembl:ENSP00000323065|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000179271(gene)|ensembl:ENST00000316939(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005840"(ribosome)|go:"GO:0007049"(cell cycle)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR018472|interpro:IPR043035|mint:Q8TAE8|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lFY+2Pev2sxqaW9nhzemL0QO52s9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NR46	intact:EBI-1257113	intact:EBI-749607|uniprotkb:A8MPS4|uniprotkb:Q8WY61|uniprotkb:Q96JH9|uniprotkb:A6NC47|ensembl:ENSP00000361640|ensembl:ENSP00000361645	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:shlb2_human(display_long)|uniprotkb:SH3 domain-containing GRB2-like protein B2(gene name synonym)|uniprotkb:SH3GLB2(gene name)|psi-mi:SH3GLB2(display_short)|uniprotkb:KIAA1848(gene name synonym)|uniprotkb:PP578(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_064530.1|refseq:NP_001273974.1|refseq:NP_001273975.1|refseq:XP_005252158.1|ensembl:ENSG00000148341(gene)|ensembl:ENST00000372559(transcript)|ensembl:ENST00000372564(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035640|interpro:IPR036028|mint:Q9NR46	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9C0QF9xLb5A6eYQBK2aU/J1aGVo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q93008	intact:EBI-1257113	intact:EBI-302524|intact:EBI-1058656|intact:EBI-28978998|ensembl:ENSP00000367558|uniprotkb:O75550|uniprotkb:Q8WWT3|uniprotkb:Q8WX12	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:usp9x_human(display_long)|uniprotkb:USP9X(gene name)|psi-mi:USP9X(display_short)|uniprotkb:DFFRX(gene name synonym)|uniprotkb:USP9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:FAM(gene name synonym)|uniprotkb:Fat facets in mammals(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000124486(gene)|ensembl:ENST00000378308(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007292"(female gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-2173795|reactome:R-HSA-5689880|reactome:R-HSA-8866652|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9033241|reactome:R-HSA-977225|go:"GO:0048675"(axon extension)|refseq:NP_001034679.2|refseq:NP_001034680.2|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR031226|interpro:IPR038765|mint:Q93008|rcsb pdb:5VBD|rcsb pdb:5WCH|ensembl:ENST00000324545|ensembl:ENSP00000316357|ensembl:ENSP00000367558|dip:DIP-27562N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f9AWz8rAV8rMTqcQ46VrYYLTHq89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15796	intact:EBI-1257113	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42226	intact:EBI-1257113	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75582	intact:EBI-1257113	intact:EBI-73869|uniprotkb:O95316|uniprotkb:Q96AF7|uniprotkb:B7Z2Y5|intact:EBI-14183507|intact:EBI-12850788|ensembl:ENSP00000479667	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ks6a5_human(display_long)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 5(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)|uniprotkb:RPS6KA5(gene name)|psi-mi:RPS6KA5(display_short)|uniprotkb:MSK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004746.2|refseq:NP_872198.1|refseq:NP_001309164.1|refseq:NP_001309166.1|dip:DIP-30894N|ensembl:ENSG00000100784(gene)|ensembl:ENST00000614987(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0043990"(histone H2A-S1 phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:O75582|rcsb pdb:1VZO|rcsb pdb:3KN5|rcsb pdb:3KN6|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-5621575	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8W2PRa/aVTLxiBJEbbXoebPqlco9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P18031	intact:EBI-1257113	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51452	intact:EBI-1257113	intact:EBI-1049755|uniprotkb:Q5U0J1|uniprotkb:D3DX45|ensembl:ENSP00000226004|uniprotkb:Q8IYJ9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dus3_human(display_long)|uniprotkb:Dual specificity protein phosphatase VHR(gene name synonym)|uniprotkb:DUSP3(gene name)|psi-mi:DUSP3(display_short)|uniprotkb:VHR(gene name synonym)|uniprotkb:Vaccinia H1-related phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004081.1|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033549"(MAP kinase phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020405|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1J4X|rcsb pdb:1VHR|rcsb pdb:3F81|reactome:R-HSA-202670|ensembl:ENSG00000108861(gene)|ensembl:ENST00000226004(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1kqI9JZrOBsMIH4M2AoWBOmQPko9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BQ95	intact:EBI-1257113	intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86TI0	intact:EBI-1257113	intact:EBI-1644036|uniprotkb:Q96K82|uniprotkb:Q9UPP4|uniprotkb:B7Z3D9|uniprotkb:E9PGH8|ensembl:ENSP00000261439	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbcd1_human(display_long)|uniprotkb:TBC1D1(gene name)|psi-mi:TBC1D1(display_short)|uniprotkb:KIAA1108(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055988.2|refseq:NP_001240841.1|ensembl:ENSG00000065882(gene)|ensembl:ENST00000261439(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:Q86TI0|rcsb pdb:3QYE|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+tRzQ4X+dhS4c3md7N2TaJdHIWY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75503	intact:EBI-1257113	intact:EBI-1043514|ensembl:ENSP00000366673|ensembl:ENSP00000490181|uniprotkb:B3KQK7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cln5_human(display_long)|uniprotkb:CLN5(gene name)|psi-mi:CLN5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000102805(gene)|ensembl:ENST00000377453(transcript)|ensembl:ENST00000636183(transcript)|go:"GO:0005537"(mannose binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006465"(signal peptide processing)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042551"(neuron maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|go:"GO:1904426"(positive regulation of GTP binding)|interpro:IPR026138|go:"GO:0022008"(neurogenesis)|refseq:NP_006484.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YBJqxznEkJjC7Rdm95cpHHBPuE49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96EV8	intact:EBI-1257113	intact:EBI-465804|uniprotkb:Q5THY3|uniprotkb:Q5THY4|uniprotkb:Q96NV2|intact:EBI-28986386|ensembl:ENSP00000341680|uniprotkb:Q9H0U2|uniprotkb:Q9H3J5|uniprotkb:A8K3V3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dtbp1_human(display_long)|uniprotkb:My031(orf name)|uniprotkb:DTNBP1(gene name)|psi-mi:DTNBP1(display_short)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:BLOC1S8(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000047579(gene)|ensembl:ENST00000344537(transcript)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0005737"(cytoplasm)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-HSA-432722|go:"GO:0048490"(anterograde synaptic vesicle transport)|refseq:NP_115498.2|refseq:NP_898861.1|refseq:NP_001258597.1|refseq:NP_001258598.1|ensembl:ENST00000338950|ensembl:ENSP00000344718|ensembl:ENSP00000341680|refseq:NP_001258596.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PBwxp1vobm9l5yGoqev97lzkMHg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UMY4	intact:EBI-1257113	intact:EBI-1752602|uniprotkb:Q8WUG9|ensembl:ENSP00000363392|ensembl:ENSP00000481314|uniprotkb:F8W8K5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx12_human(display_long)|uniprotkb:SNX12(gene name)|psi-mi:SNX12(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001243117.1|refseq:NP_001243114.1|refseq:NP_037478.2|ensembl:ENSG00000147164(gene)|ensembl:ENST00000374274(transcript)|ensembl:ENST00000622277(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030904"(retromer complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|rcsb pdb:2CSK	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ObeH0uH+d+BSI0bhoKXDrIte/nY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14936	intact:EBI-1257113	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11279	intact:EBI-1257113	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99962	intact:EBI-1257113	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13277	intact:EBI-1257113	intact:EBI-1394295|uniprotkb:O43750|uniprotkb:O43751|uniprotkb:Q15360|uniprotkb:B4DME0|ensembl:ENSP00000338562	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx3_human(display_long)|uniprotkb:STX3(gene name)|psi-mi:STX3(display_short)|uniprotkb:STX3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004168.1|refseq:NP_001171511.1|refseq:XP_005274252.1|refseq:XP_005274257.1|ensembl:ENSG00000166900(gene)|ensembl:ENST00000337979(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR031186|mint:Q13277|reactome:R-HSA-449836	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M/ue1L+l8LnUJNpEWVZ/KWR5UjM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5S2	intact:EBI-1257113	intact:EBI-1043430|uniprotkb:Q2L7A5|uniprotkb:Q86TJ1|uniprotkb:Q9ULU5|ensembl:ENSP00000355237|uniprotkb:A9JR72	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mrckb_human(display_long)|uniprotkb:CDC42-binding protein kinase beta(gene name synonym)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase beta(gene name synonym)|uniprotkb:DMPK-like beta(gene name synonym)|uniprotkb:CDC42BPB(gene name)|psi-mi:CDC42BPB(display_short)|uniprotkb:KIAA1124(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSG00000198752(gene)|ensembl:ENST00000361246(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR031597|interpro:IPR033232|interpro:IPR042718|rcsb pdb:3QFV|rcsb pdb:3TKU|rcsb pdb:4UAK|rcsb pdb:4UAL|rcsb pdb:5OTE|rcsb pdb:5OTF|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|refseq:NP_006026.3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FaheT9htZ/NtYfTKvNDcLqNtQiQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13572	intact:EBI-1257113	intact:EBI-751027|uniprotkb:Q9BTL6|uniprotkb:Q9H2E7|ensembl:ENSP00000267615|ensembl:ENSP00000451091|ensembl:ENSP00000483767|ensembl:ENSP00000486991	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:itpk1_human(display_long)|uniprotkb:Inositol 1,3,4-trisphosphate 5/6-kinase(gene name synonym)|uniprotkb:ITPK1(gene name)|psi-mi:ITPK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001136065.1|refseq:NP_001136066.1|refseq:NP_055031.2|dip:DIP-60016N|go:"GO:0021915"(neural tube development)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0047325"(inositol tetrakisphosphate 1-kinase activity)|go:"GO:0052725"(inositol-1,3,4-trisphosphate 6-kinase activity)|go:"GO:0052726"(inositol-1,3,4-trisphosphate 5-kinase activity)|go:"GO:0052746"(inositol phosphorylation)|go:"GO:0070266"(necroptotic process)|interpro:IPR008656(Inositol 1, 3, 4-trisphosphate 56-kinase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR040464|interpro:IPR041429|rcsb pdb:2ODT|rcsb pdb:2Q7D|rcsb pdb:2QB5|reactome:R-HSA-1855167|reactome:R-HSA-1855204|reactome:R-HSA-983231|ensembl:ENSG00000100605(gene)|ensembl:ENSG00000274958(gene)|ensembl:ENST00000267615(transcript)|ensembl:ENST00000556603(transcript)|ensembl:ENST00000614271(transcript)|ensembl:ENST00000626153(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000825"(inositol tetrakisphosphate 6-kinase activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016853"(isomerase activity)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ctUD8uOEz+70jTAwW0e/bWp5OA49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51151	intact:EBI-1257113	intact:EBI-4401353|uniprotkb:Q6ICN1|uniprotkb:A8K390|ensembl:ENSP00000420127|ensembl:ENSP00000480777	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab9a_human(display_long)|uniprotkb:RAB9A(gene name)|psi-mi:RAB9A(display_short)|uniprotkb:RAB9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016885453.1|refseq:NP_001182257.1|refseq:NP_004242.1|dip:DIP-46409N|ensembl:ENSG00000123595(gene)|ensembl:ENST00000464506(transcript)|ensembl:ENST00000618931(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0052405"|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041824|mint:P51151|rcsb pdb:1WMS|reactome:R-HSA-6811440|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9706019	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:x0BjgzGEj7mPNlt2CQLkHtqQzDQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H2M9	intact:EBI-1257113	intact:EBI-536107|uniprotkb:O75872|uniprotkb:Q9HAB0|uniprotkb:Q9UFJ7|uniprotkb:Q9UQ15|ensembl:ENSP00000351832|uniprotkb:A6H8V0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rbgpr_human(display_long)|uniprotkb:Rab3 GTPase-activating protein 150 kDa subunit(gene name synonym)|uniprotkb:Rab3-GAP p150(gene name synonym)|uniprotkb:Rab3-GAP regulatory subunit(gene name synonym)|uniprotkb:RGAP-iso(gene name synonym)|uniprotkb:KIAA0839(gene name synonym)|uniprotkb:RAB3GAP2(gene name)|psi-mi:RAB3GAP2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036546.2|ensembl:ENSG00000118873(gene)|ensembl:ENST00000358951(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR026059|interpro:IPR029257|interpro:IPR032839|mint:Q9H2M9|reactome:R-HSA-6811436|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Xix4Ih2/G7zRKyw0kxH0GlV4j4o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBK7-2	intact:EBI-1257113	intact:EBI-4402837|ensembl:ENSP00000376870|ensembl:ENSP00000507832	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q9ubk7-2(display_long)|uniprotkb:RABL2A(gene name)|psi-mi:RABL2A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-4402813(isoform-parent)|uniprotkb:Q9UBK7-2(isoform-parent)|ensembl:ENSG00000144134(gene)|ensembl:ENST00000393165(transcript)|ensembl:ENST00000683472(transcript)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MKTfqG40chWEYqVqj7iVgyuw8Ag9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NZ43	intact:EBI-1257113	intact:EBI-742842|uniprotkb:Q8NCK1|uniprotkb:Q9BRT4|ensembl:ENSP00000263897	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:use1_human(display_long)|uniprotkb:USE1L(gene name synonym)|uniprotkb:USE1-like protein(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM26(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:USE1(gene name)|psi-mi:USE1(display_short)|uniprotkb:MDS032(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060937.1|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007041"(lysosomal transport)|go:"GO:0015031"(protein transport)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031201"(SNARE complex)|go:"GO:0032940"(secretion by cell)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR019150|reactome:R-HSA-6811434|ensembl:ENSG00000053501(gene)|ensembl:ENST00000263897(transcript)|go:"GO:0005484"(SNAP receptor activity)|refseq:XP_016882464.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Q1yMpc/L7/G3M+SehF5ix99OkVM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13795	intact:EBI-1257113	intact:EBI-4402792|uniprotkb:E1P5J9|uniprotkb:Q6IBQ0|uniprotkb:A0A087WY13|uniprotkb:V9GYH4|uniprotkb:B7ZKX7|ensembl:ENSP00000479616|ensembl:ENSP00000479940|ensembl:ENSP00000483486	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arfrp_human(display_long)|uniprotkb:ARFRP1(gene name)|psi-mi:ARFRP1(display_short)|uniprotkb:ARP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001128230.1|refseq:NP_003215.1|refseq:XP_011526784.1|refseq:XP_011526785.1|refseq:NP_001254474.1|refseq:NP_001254475.1|refseq:NP_001254476.1|refseq:NP_001254477.1|refseq:NP_001254478.1|refseq:XP_016883065.1|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-HSA-6811440|go:"GO:0033365"(protein localization to organelle)|ensembl:ENSG00000101246(gene)|ensembl:ENST00000618838(transcript)|ensembl:ENST00000619493(transcript)|ensembl:ENST00000622789(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Sh4Hh6c3BYS03iQYq6HTgt0rhso9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99828	intact:EBI-1257113	intact:EBI-372594|uniprotkb:B5BU40|uniprotkb:O00693|uniprotkb:O00735|uniprotkb:Q6IB49|uniprotkb:Q96J54|uniprotkb:Q99971|uniprotkb:H6WJF3|ensembl:ENSP00000333873	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cib1_human(display_long)|uniprotkb:Calmyrin(gene name synonym)|uniprotkb:DNA-PKcs-interacting protein(gene name synonym)|uniprotkb:Kinase-interacting protein(gene name synonym)|uniprotkb:SNK-interacting protein 2-28(gene name synonym)|uniprotkb:CIB1(gene name)|psi-mi:CIB1(display_short)|uniprotkb:CIB(gene name synonym)|uniprotkb:KIP(gene name synonym)|uniprotkb:PRKDCIP(gene name synonym)|uniprotkb:Calcium- and integrin-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006375.2|go:"GO:0002931"(response to ischemia)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008427"(calcium-dependent protein kinase inhibitor activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030220"(platelet formation)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032433"(filopodium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|ensembl:ENSG00000185043(gene)|ensembl:ENST00000328649(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000256"(positive regulation of male germ cell proliferation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q99828|rcsb pdb:1DGU|rcsb pdb:1DGV|rcsb pdb:1XO5|rcsb pdb:1Y1A|rcsb pdb:2L4H|rcsb pdb:2L4I|rcsb pdb:6OCX|rcsb pdb:6OD0|rcsb pdb:2LM5|refseq:NP_001264693.1|dip:DIP-31260N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6nPuuJSN/emL6jukTGtT2ab+jNU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14108	intact:EBI-1257113	intact:EBI-1564650|uniprotkb:Q53Y63|uniprotkb:B4DKD8|uniprotkb:E7EM68|ensembl:ENSP00000264896	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scrb2_human(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:SCARB2(gene name)|psi-mi:SCARB2(display_short)|uniprotkb:CD36L2(gene name synonym)|uniprotkb:LIMPII(gene name synonym)|uniprotkb:LIMP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001191184.1|refseq:NP_005497.1|ensembl:ENSG00000138760(gene)|ensembl:ENST00000264896(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010008"(endosome membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904978"(regulation of endosome organization)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905671"(regulation of lysosome organization)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:Q14108|rcsb pdb:4F7B|rcsb pdb:4Q4B|rcsb pdb:4Q4F|rcsb pdb:4TVZ|rcsb pdb:4TW0|rcsb pdb:4TW2|rcsb pdb:5UPH|rcsb pdb:5XBM|rcsb pdb:6I2K|reactome:R-HSA-8856825|reactome:R-HSA-8856828	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FXyG5dJv7OqGjSgl5slIqNxUqoI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P60059	intact:EBI-1257113	intact:EBI-4402709|uniprotkb:B2R4J0|uniprotkb:P38384|uniprotkb:Q6IB25|ensembl:ENSP00000341538|ensembl:ENSP00000378906|ensembl:ENSP00000388337|ensembl:ENSP00000409884	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc61g_human(display_long)|uniprotkb:SEC61G(gene name)|psi-mi:SEC61G(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012474.1|refseq:NP_055117.1|interpro:IPR008158(Protein translocase SEC61 complex gamma subunit)|interpro:IPR023391|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523|ensembl:ENSG00000132432(gene)|ensembl:ENST00000352861(transcript)|ensembl:ENST00000395535(transcript)|ensembl:ENST00000415949(transcript)|ensembl:ENST00000450622(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0045047"(protein targeting to ER)|go:"GO:0071261"(Ssh1 translocon complex)|interpro:IPR001901(Protein secE/sec61-gamma protein)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zWwGsMkSqZ4mZP7YH1E9WI2QETs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UI12	intact:EBI-1257113	intact:EBI-724719|uniprotkb:Q6PK44|uniprotkb:Q9H3E3|uniprotkb:Q9Y300|uniprotkb:B3KMR0|ensembl:ENSP00000352522|ensembl:ENSP00000379995	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vath_human(display_long)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 50/57 kDa subunits(gene name synonym)|uniprotkb:Vacuolar proton pump subunit SFD(gene name synonym)|uniprotkb:Protein VMA13 homolog(gene name synonym)|uniprotkb:Nef-binding protein 1(gene name synonym)|uniprotkb:ATP6V1H(gene name)|psi-mi:ATP6V1H(display_short)|uniprotkb:CGI-11(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057025.2|refseq:NP_998784.1|refseq:NP_998785.1|ensembl:ENSG00000047249(gene)|ensembl:ENST00000359530(transcript)|ensembl:ENST00000396774(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|mint:Q9UI12|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-167590|reactome:R-HSA-182218|reactome:R-HSA-917977|reactome:R-HSA-9636467|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:XP_006716518.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:n2fyA8m4qnlSmS3R1xBBE3RRV9A9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y2T2	intact:EBI-1257113	intact:EBI-2371151|uniprotkb:Q5JQ12|uniprotkb:Q9H5L2|ensembl:ENSP00000347408|ensembl:ENSP00000361831	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap3m1_human(display_long)|uniprotkb:AP-3 adaptor complex mu3A subunit(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit mu-1(gene name synonym)|uniprotkb:AP3M1(gene name)|psi-mi:AP3M1(display_short)|uniprotkb:Mu-adaptin 3A(gene name synonym)|uniprotkb:Mu3A-adaptin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001307192.1|refseq:NP_001307193.1|refseq:NP_036227.1|refseq:NP_996895.1|ensembl:ENSG00000185009(gene)|ensembl:ENST00000355264(transcript)|ensembl:ENST00000372745(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|mint:Q9Y2T2|reactome:R-HSA-390471	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VsXYkOxEite1RzT1YHCA6/U4gj09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBQ0	intact:EBI-1257113	intact:EBI-718596|uniprotkb:Q502Y5|uniprotkb:Q9H0W0|uniprotkb:Q9NRP1|uniprotkb:Q6FIF8|uniprotkb:Q6IAH3|uniprotkb:Q9NRU7|ensembl:ENSP00000447058	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps29_human(display_long)|uniprotkb:Vesicle protein sorting 29(gene name synonym)|uniprotkb:PEP11 homolog(gene name synonym)|uniprotkb:VPS29(gene name)|psi-mi:VPS29(display_short)|uniprotkb:DC7(orf name)|uniprotkb:DC15(orf name)|uniprotkb:MDS007(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057310.1|refseq:NP_476528.1|ensembl:ENSG00000111237(gene)|ensembl:ENST00000549578(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|rcsb pdb:1W24|rcsb pdb:2R17|rcsb pdb:5GTU|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:5WYH|rcsb pdb:7BLN|reactome:R-HSA-3238698|dip:DIP-29077N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xjo28jAH7expkdli0DENjzLXpjw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRW7	intact:EBI-1257113	intact:EBI-1782543|uniprotkb:Q15715|uniprotkb:Q9Y4Z6|uniprotkb:Q5T4P6|uniprotkb:F5H8K1|uniprotkb:Q53FR8|uniprotkb:D3DUZ9|ensembl:ENSP00000495563	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps45_human(display_long)|uniprotkb:VPS45(gene name)|psi-mi:VPS45(display_short)|uniprotkb:VPS45A(gene name synonym)|uniprotkb:VPS45B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-46823N|refseq:NP_009190.2|refseq:NP_001266282.1|refseq:NP_001266283.1|ensembl:ENSG00000136631(gene)|ensembl:ENST00000644510(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|reactome:R-HSA-6811438|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EO8eXkh8EW/0AN2p5OqHL4yvXV09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P43487	intact:EBI-1257113	intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P54802	intact:EBI-1257113	intact:EBI-4402668|ensembl:ENSP00000225927	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anag_human(display_long)|uniprotkb:NAGLU(gene name)|psi-mi:NAGLU(display_short)|uniprotkb:UFHSD1(gene name synonym)|uniprotkb:N-acetyl-alpha-glucosaminidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000108784(gene)|ensembl:ENST00000225927(transcript)|go:"GO:0004561"(alpha-N-acetylglucosaminidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007399"(nervous system development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007781(Alpha-N-acetylglucosaminidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|refseq:NP_000254.2|interpro:IPR024240|interpro:IPR024732|interpro:IPR024733|interpro:IPR029018|rcsb pdb:4XWH|reactome:R-HSA-2024096|reactome:R-HSA-2206282	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ntho16w2Zcr+3KhW8FgKWemVngE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P43405	intact:EBI-1257113	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63151	intact:EBI-1257113	intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:evS6klM2alZXtMthVsshKkrNgiA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y3E0	intact:EBI-1257113	intact:EBI-4402607|uniprotkb:B2R4R4|uniprotkb:Q54A40|uniprotkb:Q6I9W6|uniprotkb:Q9P1R9|ensembl:ENSP00000229314	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:got1b_human(display_long)|uniprotkb:GOLT1B(gene name)|psi-mi:GOLT1B(display_short)|uniprotkb:GOT1A(gene name synonym)|uniprotkb:Golgi transport 1 homolog B(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 470(gene name synonym)|uniprotkb:hGOT1a(gene name synonym)|uniprotkb:CGI-141(orf name)|uniprotkb:HDCMA39P(orf name)|uniprotkb:UNQ432/PRO793(orf name)|uniprotkb:GCT2(gene name synonym)|uniprotkb:Germ cell tumor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057156.1|ensembl:ENSG00000111711(gene)|ensembl:ENST00000229314(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR007305(Got1-like protein)|mint:Q9Y3E0	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dvlUtRzzjPZ9BTUtxhy2Sb3KB4Q9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P21281	intact:EBI-1257113	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P37802	intact:EBI-1257113	intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13535	intact:EBI-1257113	intact:EBI-968983|ensembl:ENSP00000343741|uniprotkb:Q7KYL3|uniprotkb:Q93051|uniprotkb:Q9BXK4|uniprotkb:Q59HB2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:atr_human(display_long)|uniprotkb:ATR(gene name)|psi-mi:ATR(display_short)|uniprotkb:FRP1(gene name synonym)|uniprotkb:Ataxia telangiectasia and Rad3-related protein(gene name synonym)|uniprotkb:FRAP-related protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000175054(gene)|ensembl:ENST00000350721(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031297"(replication fork processing)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042493"|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021133|interpro:IPR036940|mint:Q13535|rcsb pdb:5YZ0|reactome:R-HSA-1221632|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001175.2|refseq:XP_016862132.1|dip:DIP-35308N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZYzDNmnxcK+RJN42KfgQZlxGACU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92974	intact:EBI-1257113	intact:EBI-302405|intact:EBI-1045693|uniprotkb:O75142|uniprotkb:Q15079|uniprotkb:Q5VY92|uniprotkb:Q8TDA3|uniprotkb:Q8WUG4|uniprotkb:Q9H023|ensembl:ENSP00000354837|uniprotkb:D3DVA6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arhg2_human(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:KIAA0651(gene name synonym)|uniprotkb:LFP40(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Microtubule-regulated Rho-GEF(gene name synonym)|uniprotkb:Proliferating cell nucleolar antigen p40(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001155855.1|refseq:NP_001155856.1|refseq:NP_004714.2|ensembl:ENSG00000116584(gene)|ensembl:ENST00000361247(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q92974|rcsb pdb:5EFX|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GljUl7uzMi3HaFQsMybfT6KrW089606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRD5	intact:EBI-1257113	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UM54	intact:EBI-1257113	intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NVJ2	intact:EBI-1257113	intact:EBI-718376|uniprotkb:B4DI85|ensembl:ENSP00000256496	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl8b_human(display_long)|uniprotkb:ADP-ribosylation factor-like protein 10C(gene name synonym)|uniprotkb:Novel small G protein indispensable for equal chromosome segregation 1(gene name synonym)|uniprotkb:ARL8B(gene name)|psi-mi:ARL8B(display_short)|uniprotkb:ARL10C(gene name synonym)|uniprotkb:GIE1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060654.1|ensembl:ENSG00000134108(gene)|ensembl:ENST00000256496(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002505"(antigen processing and presentation of polysaccharide antigen via MHC class II)|go:"GO:0002747"(antigen processing and presentation following phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032418"(lysosome localization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045202"(synapse)|go:"GO:0046754"(viral exocytosis)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990927"(calcium ion regulated lysosome exocytosis)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|go:"GO:0031902"(late endosome membrane)|interpro:IPR044154|mint:Q9NVJ2|rcsb pdb:2AL7	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DLTh63yjvilHei1RUU6P4Ad0TAo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BRG1	intact:EBI-1257113	intact:EBI-741945|uniprotkb:B2R581|ensembl:ENSP00000253794	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps25_human(display_long)|uniprotkb:ELL-associated protein of 20 kDa(gene name synonym)|uniprotkb:Dermal papilla-derived protein 9(gene name synonym)|uniprotkb:VPS25(gene name)|psi-mi:VPS25(display_short)|uniprotkb:DERP9(gene name synonym)|uniprotkb:EAP20(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000253794(transcript)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000131475(gene)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008570(ESCRT-II complex, vps25 subunit)|interpro:IPR014041(ESCRT-II complex, vps25 subunit, N-terminal winged helix)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2ZME|rcsb pdb:3CUQ|rcsb pdb:3HTU|reactome:R-HSA-917729|reactome:R-HSA-9610379|refseq:NP_115729.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fAf3o5rwpM1xz53oIyMwohQfbEg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35240	intact:EBI-1257113	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P09496	intact:EBI-1257113	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7Z3U7	intact:EBI-1257113	intact:EBI-358882|uniprotkb:A5D8U7|uniprotkb:A7E2Y0|uniprotkb:Q86TA2|uniprotkb:Q8N3I5|uniprotkb:Q8NAI0|uniprotkb:Q9UPW1|intact:EBI-2829603|intact:EBI-358896|uniprotkb:Q8NHE2|uniprotkb:B9EGP5|uniprotkb:F8VWA6|uniprotkb:F8W1Z6|intact:EBI-10962461|ensembl:ENSP00000377250	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mon2_human(display_long)|uniprotkb:MON2(gene name)|psi-mi:MON2(display_short)|uniprotkb:KIAA1040(gene name synonym)|uniprotkb:SF21(gene name synonym)|uniprotkb:Protein SF21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001265399.1|refseq:NP_001265398.1|refseq:NP_055841.2|refseq:XP_016874530.1|ensembl:ENSG00000061987(gene)|ensembl:ENST00000393630(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026829|interpro:IPR032629|interpro:IPR032691|interpro:IPR032817|mint:Q7Z3U7	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pEkENsLrswc7Cb2WTKZfQdESrtQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15208	intact:EBI-1257113	intact:EBI-458376|ensembl:ENSP00000229812|uniprotkb:Q503A1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stk38_human(display_long)|uniprotkb:NDR1(gene name synonym)|uniprotkb:STK38(gene name)|psi-mi:STK38(display_short)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000112079(gene)|ensembl:ENST00000229812(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q15208|rcsb pdb:1PSB|rcsb pdb:6BXI|reactome:R-HSA-9013418|reactome:R-HSA-9013422|refseq:NP_009202.1|refseq:XP_006715051.1|refseq:XP_006715052.1|refseq:NP_001292031.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YHzdDrPEH6YdhOXtcnLWArqftck9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UNH6	intact:EBI-1257113	intact:EBI-751422|uniprotkb:Q86U82|uniprotkb:Q8WVD4|uniprotkb:Q96FW9|uniprotkb:Q9Y3Z7|uniprotkb:Q53FQ3|uniprotkb:Q5VT10|uniprotkb:A8KAF3|uniprotkb:Q5VT09|uniprotkb:D3DT50	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx7_human(display_long)|uniprotkb:SNX7(gene name)|psi-mi:SNX7(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR028656|refseq:NP_057060.2|refseq:NP_689424.2|interpro:IPR001683(Phox-like)|rcsb pdb:3IQ2|interpro:IPR042130|interpro:IPR042131|refseq:XP_011539866.1|refseq:XP_006710741.1|refseq:XP_016856914.1|refseq:XP_016856915.1|refseq:XP_016856916.1|refseq:XP_016856917.1|interpro:IPR027267|interpro:IPR036871|go:"GO:0015031"(protein transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035091"(phosphatidylinositol binding)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:d6/b2HkbwDVHzwy2tV9cCOX7y9E9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HA65	intact:EBI-1257113	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HB21	intact:EBI-1257113	intact:EBI-2652984|uniprotkb:Q9BVK0|uniprotkb:D3DRE2|uniprotkb:B3KQ55|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkha1_human(display_long)|uniprotkb:PLEKHA1(gene name)|psi-mi:PLEKHA1(display_short)|uniprotkb:TAPP1(gene name synonym)|uniprotkb:Tandem PH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001001974.1|refseq:NP_001182537.1|refseq:NP_067635.2|refseq:NP_001317107.1|refseq:XP_016871969.1|refseq:XP_016871970.1|refseq:XP_016871971.1|refseq:XP_016871979.1|refseq:XP_016871980.1|ensembl:ENSG00000107679(gene)|ensembl:ENST00000368990(transcript)|ensembl:ENST00000392799(transcript)|ensembl:ENST00000433307(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-HSA-1660499|rcsb pdb:1EAZ|refseq:XP_005270073.1|refseq:XP_005270078.1|ensembl:ENST00000368988|ensembl:ENSP00000357984|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:a4aD7YitZrTeGt2rr8x7+nikTlg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15127	intact:EBI-1257113	intact:EBI-712703|uniprotkb:Q9BQE8|intact:EBI-28966746|ensembl:ENSP00000268099|uniprotkb:B2RDF0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam2_human(display_long)|uniprotkb:SCAMP2(gene name)|psi-mi:SCAMP2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000268099|ensembl:ENSG00000140497(gene)|ensembl:ENST00000268099(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O15127|refseq:NP_005688.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wV3Omfpe2RLQlt8LYk8XUiuf20o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14683	intact:EBI-1257113	intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96CM8	intact:EBI-1257113	intact:EBI-2876502|ensembl:ENSP00000300441|uniprotkb:Q9H7G2|uniprotkb:B4DFQ6|uniprotkb:B4DHT5|uniprotkb:B4DUF5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:acsf2_human(display_long)|uniprotkb:ACSF2(gene name)|psi-mi:ACSF2(display_short)|uniprotkb:UNQ493/PRO1009(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000167107(gene)|ensembl:ENST00000300441(transcript)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0031956"(medium-chain fatty acid-CoA ligase activity)|go:"GO:0047760"(butyrate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|mint:Q96CM8|reactome:R-HSA-77289|go:"GO:0006631"(fatty acid metabolic process)|refseq:NP_001275897.1|refseq:NP_001275898.1|refseq:NP_001275899.1|refseq:NP_001275900.1|refseq:NP_079425.3|refseq:NP_001275901.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yn41ilnswMEfm0Y8mmbhKneGJdU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q969E2	intact:EBI-1257113	intact:EBI-4403649|uniprotkb:Q8N2N1|uniprotkb:Q8NAV0|ensembl:ENSP00000316007|ensembl:ENSP00000479083	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam4_human(display_long)|uniprotkb:SCAMP4(gene name)|psi-mi:SCAMP4(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_524558.1|ensembl:ENSP00000316007|ensembl:ENST00000409472|ensembl:ENSP00000386865|ensembl:ENSP00000479083|refseq:NP_001316468.1|refseq:NP_001316469.1|ensembl:ENSG00000227500(gene)|ensembl:ENST00000316097(transcript)|ensembl:ENST00000621748(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q969E2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:v18OIK4oYkJy0N/aB+qyMkivYis9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95070	intact:EBI-1257113	intact:EBI-2799703|uniprotkb:Q9BVD0|uniprotkb:A6NM00|uniprotkb:Q96G83|ensembl:ENSP00000366098	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:yif1a_human(display_long)|uniprotkb:54TM(gene name synonym)|uniprotkb:HYIF1P(gene name synonym)|uniprotkb:YIF1(gene name synonym)|uniprotkb:54TMp(gene name synonym)|uniprotkb:YIP1-interacting factor homolog A(gene name synonym)|uniprotkb:YIF1A(gene name)|psi-mi:YIF1A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065203.2|ensembl:ENSG00000174851(gene)|ensembl:ENST00000376901(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005578(Hrf1)|mint:O95070|reactome:R-HSA-381038	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:udkO5o876pUyTxBnhOchiirpW0U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UQE7	intact:EBI-1257113	intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y296	intact:EBI-1257113	intact:EBI-722888|uniprotkb:B4DME1|uniprotkb:A8K3A5|intact:EBI-28967645|ensembl:ENSP00000436005|ensembl:ENSP00000487467	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tppc4_human(display_long)|uniprotkb:Synbindin(gene name synonym)|uniprotkb:TRS23 homolog(gene name synonym)|uniprotkb:Hematopoietic stem/progenitor cell protein 172(gene name synonym)|uniprotkb:TRAPPC4(gene name)|psi-mi:TRAPPC4(display_short)|uniprotkb:SBDN(gene name synonym)|uniprotkb:CGI-104(orf name)|uniprotkb:HSPC172(orf name)|uniprotkb:PTD009(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000487467|ensembl:ENST00000629713|ensembl:ENSP00000486496|refseq:NP_057230.1|ensembl:ENST00000434101|ensembl:ENSP00000405033|ensembl:ENSP00000436005|refseq:NP_001305415.1|refseq:NP_001305417.1|refseq:NP_001305418.1|refseq:NP_001305419.1|refseq:NP_001305421.1|refseq:NP_001305423.1|dip:DIP-37871N|ensembl:ENSG00000196655(gene)|ensembl:ENSG00000280495(gene)|ensembl:ENST00000533632(transcript)|ensembl:ENST00000629243(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016358"(dendrite development)|go:"GO:0030008"(TRAPP complex)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR007233(Sybindin-like protein)|interpro:IPR011012(Longin-like)|rcsb pdb:2J3T|rcsb pdb:2JSN|rcsb pdb:2ZMV|reactome:R-HSA-204005|reactome:R-HSA-3000170|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9Dqiz8Vo+JYaAoNESIFFuhf2yc09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13445	intact:EBI-1257113	intact:EBI-4310995|ensembl:ENSP00000214869	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tmed1_human(display_long)|uniprotkb:TMED1(gene name)|psi-mi:TMED1(display_short)|uniprotkb:IL1RL1L(gene name synonym)|uniprotkb:IL1RL1LG(gene name synonym)|uniprotkb:Interleukin-1 receptor-like 1 ligand(gene name synonym)|uniprotkb:Putative T1/ST2 receptor-binding protein(gene name synonym)|uniprotkb:p24 family protein gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006849.1|ensembl:ENSG00000099203(gene)|ensembl:ENST00000214869(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|mint:Q13445	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PQHIGiwN0HhCGcpm1HGn/WF3t9U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62158	intact:EBI-1257113	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y266	intact:EBI-1257113	intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P35606	intact:EBI-1257113	intact:EBI-1056534|uniprotkb:B4DZI8|intact:EBI-11019844|ensembl:ENSP00000329419	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copb2_human(display_long)|uniprotkb:COPB2(gene name)|psi-mi:COPB2(display_short)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004757.1|ensembl:ENSG00000184432(gene)|ensembl:ENST00000333188(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:P35606|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_016863001.1|dip:DIP-27603N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zkd7lOeV+OvHglnAJg6cXoMhgbg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95292	intact:EBI-1257113	intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86VN1	intact:EBI-1257113	intact:EBI-4401822|uniprotkb:A8K125|uniprotkb:Q3ZCV7|uniprotkb:Q5H9S1|uniprotkb:Q5VXB6|uniprotkb:Q9H8Z5|uniprotkb:Q9Y3E3|ensembl:ENSP00000367299	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps36_human(display_long)|uniprotkb:VPS36(gene name)|psi-mi:VPS36(display_short)|uniprotkb:C13orf9(gene name synonym)|uniprotkb:EAP45(gene name synonym)|uniprotkb:ELL-associated protein of 45 kDa(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS36(gene name synonym)|uniprotkb:CGI-145(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057159.2|refseq:NP_001269098.1|dip:DIP-29249N|ensembl:ENSG00000136100(gene)|ensembl:ENST00000378060(transcript)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021648|interpro:IPR036388|interpro:IPR036390|interpro:IPR037855|interpro:IPR040608|rcsb pdb:2HTH|rcsb pdb:2ZME|rcsb pdb:3CUQ|reactome:R-HSA-917729|reactome:R-HSA-9610379	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LPnQXFgph4C6q8VJu1Fgrhn6clM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P289	intact:EBI-1257113	intact:EBI-618239|intact:EBI-1774248|uniprotkb:Q8NC04|uniprotkb:Q9BXC3|ensembl:ENSP00000377867|uniprotkb:Q9BXC4|uniprotkb:Q3ZB77|uniprotkb:B2RAU2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stk26_human(display_long)|uniprotkb:STK26(gene name)|psi-mi:STK26(display_short)|uniprotkb:MASK(gene name synonym)|uniprotkb:MST3 and SOK1-related kinase(gene name synonym)|uniprotkb:MST4(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase MASK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134602(gene)|ensembl:ENST00000394334(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035056|rcsb pdb:3GGF|rcsb pdb:3W8I|rcsb pdb:4FZA|rcsb pdb:4FZD|rcsb pdb:4FZF|rcsb pdb:4GEH|rcsb pdb:5XY9|rcsb pdb:5YF4|rcsb pdb:7B36|reactome:R-HSA-111465|interpro:IPR000719(Protein kinase, core)|refseq:NP_001035917.1|refseq:NP_001035918.1|refseq:NP_057626.2|dip:DIP-34049N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:V6BRp2h2O0RdLI1gRobMJKh28cA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TCY9	intact:EBI-1257113	intact:EBI-4402198|uniprotkb:Q658M4|uniprotkb:Q68DH6|uniprotkb:Q6MZZ5|uniprotkb:Q8WV98|uniprotkb:Q9NWR7|uniprotkb:Q9P221|uniprotkb:E9PFF6|ensembl:ENSP00000396918	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:urgcp_human(display_long)|uniprotkb:URGCP(gene name)|psi-mi:URGCP(display_short)|uniprotkb:KIAA1507(gene name synonym)|uniprotkb:URG4(gene name synonym)|uniprotkb:HBV X protein up-regulated gene 4 protein(gene name synonym)|uniprotkb:HBxAg up-regulated gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001277004.1|refseq:NP_001277005.1|refseq:NP_001071131.1|refseq:NP_001071132.1|refseq:NP_060390.3|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030383|mint:Q8TCY9|ensembl:ENSG00000106608(gene)|ensembl:ENST00000453200(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xoebsRj6/DnaJMLbRHX92DFt5709606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6G9	intact:EBI-1257113	intact:EBI-2556107|uniprotkb:A2RRG7|uniprotkb:Q53HK7|uniprotkb:Q53HC8|ensembl:ENSP00000273130	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dc1l1_human(display_long)|uniprotkb:DNCLI1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)|uniprotkb:DYNC1LI1(gene name)|psi-mi:DYNC1LI1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057225.2|ensembl:ENSG00000144635(gene)|ensembl:ENST00000273130(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q9Y6G9|rcsb pdb:6B9H|rcsb pdb:6PSD|rcsb pdb:6PSE|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0007018"(microtubule-based movement)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LxQSfBpzuf6Acus2jBy0s53FdhU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BPX3	intact:EBI-1257113	intact:EBI-970214|uniprotkb:Q9HBI9|ensembl:ENSP00000251496|uniprotkb:Q3MJE0|uniprotkb:Q96SV9|uniprotkb:Q9BUR3|uniprotkb:Q9BVY1|uniprotkb:Q9H914|uniprotkb:Q9H9Z6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cnd3_human(display_long)|uniprotkb:NCAPG(gene name)|psi-mi:NCAPG(display_short)|uniprotkb:NYMEL3(gene name synonym)|uniprotkb:CAPG(gene name synonym)|uniprotkb:Chromosome-associated protein G(gene name synonym)|uniprotkb:Condensin subunit CAP-G(gene name synonym)|uniprotkb:XCAP-G homolog(gene name synonym)|uniprotkb:Melanoma antigen NY-MEL-3(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000109805(gene)|ensembl:ENST00000251496(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025977|interpro:IPR027165|mint:Q9BPX3|rcsb pdb:6IGX|reactome:R-HSA-2514853|refseq:NP_071741.2|dip:DIP-34891N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:G45XQBcnTeSunRz57s6lJErxvjo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75122	intact:EBI-1257113	intact:EBI-913524|ensembl:ENSP00000417518|uniprotkb:Q7L8F6|uniprotkb:Q8N6R6|uniprotkb:Q9BQT3|uniprotkb:Q9BQT4|uniprotkb:Q9H7A3|uniprotkb:Q9NSZ2|intact:EBI-2514712|uniprotkb:B2RTR1|uniprotkb:F5H604|intact:EBI-10967478	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:clap2_human(display_long)|uniprotkb:CLASP2(gene name)|psi-mi:CLASP2(display_short)|uniprotkb:KIAA0627(gene name synonym)|uniprotkb:Cytoplasmic linker-associated protein 2(gene name synonym)|uniprotkb:Protein Orbit homolog 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163539(gene)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|ensembl:ENST00000480013(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903754"(cortical microtubule plus-end)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR034085|mint:O75122|rcsb pdb:3WOY|rcsb pdb:5NR4|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-428890|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001193973.1|refseq:NP_055912.2|dip:DIP-36804N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FNIEvRFPqFi6NPFLsVHlKvfkN9w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6NUQ1	intact:EBI-1257113	intact:EBI-726876|uniprotkb:Q75MG9|uniprotkb:Q75MH0|uniprotkb:Q96IW8|uniprotkb:Q9H229|uniprotkb:Q9HAD9|intact:EBI-28981798|ensembl:ENSP00000257700	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rint1_human(display_long)|uniprotkb:RAD50 interactor 1(gene name synonym)|uniprotkb:RINT1(gene name)|psi-mi:RINT1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000135249(gene)|ensembl:ENST00000257700(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0015031"(protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0070939"(Dsl1/NZR complex)|interpro:IPR007528(RINT-1/TIP-1)|interpro:IPR042044|reactome:R-HSA-6811434|refseq:NP_068749.3|ensembl:ENSP00000257700|dip:DIP-36477N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aUzUSBI8f6ednxeVnP97ifOMoPc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61923	intact:EBI-1257113	intact:EBI-1049939|uniprotkb:Q549N6|uniprotkb:Q9Y3C3|uniprotkb:B4DDX8|uniprotkb:F8VS17|uniprotkb:F8VWL5|uniprotkb:B4DHZ0|ensembl:ENSP00000262061	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copz1_human(display_long)|uniprotkb:Zeta-1-coat protein(gene name synonym)|uniprotkb:COPZ1(gene name)|psi-mi:COPZ1(display_short)|uniprotkb:COPZ(gene name synonym)|uniprotkb:CGI-120(orf name)|uniprotkb:HSPC181(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057141.1|refseq:NP_001258663.1|refseq:NP_001258664.1|refseq:NP_001258665.1|ensembl:ENST00000262061(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR039652|rcsb pdb:2HF6|rcsb pdb:5MC7|reactome:R-HSA-6807878|reactome:R-HSA-6811434|ensembl:ENSG00000111481(gene)|dip:DIP-29873N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1/IgMqSz7ThLUzNhR4ARUq+Gr6I9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NEV8	intact:EBI-1257113	intact:EBI-3437566|uniprotkb:Q2KHM1|uniprotkb:Q9Y4D6|ensembl:ENSP00000265843|ensembl:ENSP00000432546	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exph5_human(display_long)|uniprotkb:EXPH5(gene name)|psi-mi:EXPH5(display_short)|uniprotkb:KIAA0624(gene name synonym)|uniprotkb:SLAC2B(gene name synonym)|uniprotkb:Synaptotagmin-like protein homolog lacking C2 domains b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001294948.1|ensembl:ENSG00000110723(gene)|ensembl:ENST00000265843(transcript)|ensembl:ENST00000525344(transcript)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005768"(endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0071985"(multivesicular body sorting pathway)|interpro:IPR010911(Rab-binding)|interpro:IPR039916	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jhqVYsIzluT2Dd6KP2d2QyO6D4U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52306	intact:EBI-1257113	intact:EBI-746389|uniprotkb:Q9BUW9|ensembl:ENSP00000386153|intact:EBI-3184182|uniprotkb:G5E9P9|uniprotkb:Q499L7|uniprotkb:Q4KMV2|uniprotkb:Q9BUX6|uniprotkb:Q9NYM2|uniprotkb:Q9NZA8|intact:EBI-4397492|uniprotkb:E9PH06|uniprotkb:Q4QQI8|intact:EBI-11106358	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gds1_human(display_long)|uniprotkb:RAP1GDS1(gene name)|psi-mi:RAP1GDS1(display_short)|uniprotkb:Exchange factor smgGDS(gene name synonym)|uniprotkb:SMG GDS protein(gene name synonym)|uniprotkb:SMG P21 stimulatory GDP/GTP exchange protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_066982.3|refseq:NP_001093898.1|ensembl:ENSG00000138698(gene)|ensembl:ENST00000408927(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040144|rcsb pdb:5XGC|rcsb pdb:5ZHX|reactome:R-HSA-9013419|reactome:R-HSA-9013425|refseq:NP_001093896.1|refseq:NP_001093897.1|refseq:NP_001093899.1|refseq:NP_001093900.1|dip:DIP-61080N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CBqwhiENmk65uN7XyiVVYZ+W6R09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14008	intact:EBI-1257113	intact:EBI-310585|uniprotkb:Q0VAX8|uniprotkb:Q14668|uniprotkb:Q05D70|uniprotkb:Q0VAX7|uniprotkb:Q2TA89|uniprotkb:Q6NSH4|intact:EBI-28968667|ensembl:ENSP00000432768	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ckap5_human(display_long)|uniprotkb:CKAP5(gene name)|psi-mi:CKAP5(display_short)|uniprotkb:KIAA0097(gene name synonym)|uniprotkb:Colonic and hepatic tumor overexpressed gene protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000312055|ensembl:ENSP00000310227|ensembl:ENST00000354558|ensembl:ENSP00000346566|ensembl:ENSP00000432768|refseq:NP_001008938.1|refseq:NP_055571.2|ensembl:ENSG00000175216(gene)|ensembl:ENST00000529230(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0050658"(RNA transport)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0090063"(positive regulation of microtubule nucleation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024395|interpro:IPR034085|mint:Q14008|rcsb pdb:4QMI|rcsb pdb:4QMJ|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3bgwyNEucxXwXdbxbJkJ07PC90w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NHV4	intact:EBI-1257113	intact:EBI-2555055|uniprotkb:B0AZN0|uniprotkb:Q8NA30|ensembl:ENSP00000266742|ensembl:ENSP00000404978|uniprotkb:G3V3F1|intact:EBI-11060992|uniprotkb:B4E145	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nedd1_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)|uniprotkb:NEDD1(gene name)|psi-mi:NEDD1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001128647.1|refseq:NP_001128648.1|refseq:NP_690869.1|refseq:XP_011536205.1|ensembl:ENSG00000139350(gene)|ensembl:ENST00000266742(transcript)|ensembl:ENST00000429527(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051301"(cell division)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|interpro:IPR036322|refseq:NP_001128649.1|refseq:XP_005268701.1|refseq:XP_006719300.1|dip:DIP-48838N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ljVRvS/VGrOlrJxqy3Z+8fAew0c9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42858	intact:EBI-1257113	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UID3	intact:EBI-1257113	intact:EBI-2932923|ensembl:ENSP00000279281|uniprotkb:Q6PJV5|uniprotkb:Q7L8A6|uniprotkb:Q8WZ35|uniprotkb:Q96DF4|uniprotkb:Q96GR3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps51_human(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR014812(Vps51/Vps67)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UID3|rcsb pdb:4J2C|reactome:R-HSA-6811440|refseq:NP_037397.2|dip:DIP-60562N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P06493	intact:EBI-1257113	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49736	intact:EBI-1257113	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46459	intact:EBI-1257113	intact:EBI-712251|ensembl:ENSP00000381293|ensembl:ENSP00000478614|ensembl:ENSP00000481714|uniprotkb:Q8N6D7|uniprotkb:Q9UKZ2|uniprotkb:A8K2D9|uniprotkb:B4DFA2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nsf_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:NSF(gene name)|psi-mi:NSF(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073969(gene)|ensembl:ENSG00000276262(gene)|ensembl:ENSG00000278174(gene)|ensembl:ENST00000398238(transcript)|ensembl:ENST00000611398(transcript)|ensembl:ENST00000620290(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46459|rcsb pdb:6KZQ|reactome:R-HSA-204005|reactome:R-HSA-416993|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_006169.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:J5hsoA0RTiQkWrV7nWpnK8Dvxxg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00562	intact:EBI-1257113	intact:EBI-2861268|uniprotkb:A6NME4|uniprotkb:Q8TBN3|uniprotkb:Q6T7X3|uniprotkb:Q9BZ73|ensembl:ENSP00000348772|ensembl:ENSP00000437286	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pitm1_human(display_long)|uniprotkb:PITPNM1(gene name)|psi-mi:PITPNM1(display_short)|uniprotkb:DRES9(gene name synonym)|uniprotkb:NIR2(gene name synonym)|uniprotkb:PITPNM(gene name synonym)|uniprotkb:Drosophila retinal degeneration B homolog(gene name synonym)|uniprotkb:Phosphatidylinositol transfer protein, membrane-associated 1(gene name synonym)|uniprotkb:Pyk2 N-terminal domain-interacting receptor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001124320.1|refseq:NP_004901.2|refseq:XP_016874075.1|go:"GO:0007602"(phototransduction)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0015031"(protein transport)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044297"(cell body)|go:"GO:0070300"(phosphatidic acid binding)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR004177(DDHD)|interpro:IPR023214|interpro:IPR023393|interpro:IPR031315|interpro:IPR036412|mint:O00562|reactome:R-HSA-1483226|ensembl:ENSG00000110697(gene)|ensembl:ENST00000356404(transcript)|ensembl:ENST00000534749(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007420"(brain development)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lJDwa5NR0oz6zQCNbw8fUbVuU0E9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6P1K2	intact:EBI-1257113	intact:EBI-713832|uniprotkb:Q5TCJ8|uniprotkb:Q5TCJ9|uniprotkb:Q5TCK3|uniprotkb:Q69YZ9|uniprotkb:Q6PHR4|uniprotkb:Q86VJ6|uniprotkb:Q8N4T6|uniprotkb:Q9UBQ3|uniprotkb:A8K0C5|intact:EBI-2554676|uniprotkb:Q5TCK0|ensembl:ENSP00000357260|uniprotkb:Q5TCK1|uniprotkb:Q6ZVE6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pmf1_human(display_long)|uniprotkb:PMF1(gene name)|psi-mi:PMF1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160783(gene)|ensembl:ENST00000368277(transcript)|go:"GO:0000444"(MIS12/MIND type complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0051301"(cell division)|interpro:IPR007128(Nnf1)|mint:Q6P1K2|rcsb pdb:5LSJ|rcsb pdb:5LSK|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001186582.1|refseq:NP_001186583.1|refseq:NP_001186590.1|refseq:NP_001186592.1|refseq:NP_009152.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:76xPGmFgI3Pt1gsZMb3aD4hpPWM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13257	intact:EBI-1257113	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13228	intact:EBI-1257113	intact:EBI-711619|uniprotkb:A6NML9|uniprotkb:A6PVW9|uniprotkb:B2RDR3|uniprotkb:Q96GX7|uniprotkb:B4DKP6|uniprotkb:Q49AQ8|uniprotkb:B4E1F3|ensembl:ENSP00000357861	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sbp1_human(display_long)|uniprotkb:SELENBP1(gene name)|psi-mi:SELENBP1(display_short)|uniprotkb:SBP(gene name synonym)|uniprotkb:56 kDa selenium-binding protein(gene name synonym)|uniprotkb:Selenium-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003935.2|refseq:NP_001245218.1|refseq:NP_001245217.1|ensembl:ENSG00000143416(gene)|ensembl:ENST00000368868(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008430"(selenium binding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0018549"(methanethiol oxidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008826(Selenium-binding protein)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PqHTrxV3+3S/4C428UI+2jl6omo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UQ88	intact:EBI-1257113	intact:EBI-373024|uniprotkb:O95227|uniprotkb:O95228|uniprotkb:O96012|uniprotkb:Q12821|uniprotkb:Q12853|uniprotkb:Q12854|uniprotkb:Q5QPR0|uniprotkb:Q5QPR1|uniprotkb:Q5QPR2|uniprotkb:Q9UBC4|uniprotkb:Q9UBI3|uniprotkb:Q9UEI1|uniprotkb:Q9UEI2|uniprotkb:Q9UP53|uniprotkb:Q9UP54|uniprotkb:Q9UP55|uniprotkb:Q9UP56|uniprotkb:Q9UQ86|uniprotkb:Q9UQ87|uniprotkb:Q9UQ89|uniprotkb:Q2TAJ0|ensembl:ENSP00000367900	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cd11a_human(display_long)|uniprotkb:CDK11A(gene name)|psi-mi:CDK11A(display_short)|uniprotkb:PITSLREB(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 2(gene name synonym)|uniprotkb:Galactosyltransferase-associated protein kinase p58/GTA(gene name synonym)|uniprotkb:CDC2L2(gene name synonym)|uniprotkb:CDC2L3(gene name synonym)|uniprotkb:PITSLRE serine/threonine-protein kinase CDC2L2(gene name synonym)|uniprotkb:Cell division protein kinase 11A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_076916.2|refseq:NP_277071.2|refseq:NP_001300825.1|refseq:NP_001300911.1|ensembl:ENSG00000008128(gene)|ensembl:ENST00000378633(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q9UQ88|reactome:R-HSA-380270	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h30ee1oqCuzFkWhpX9dsmJFl9Y09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTJ3	intact:EBI-1257113	intact:EBI-356173|uniprotkb:A6NLT9|uniprotkb:O95752|uniprotkb:Q8NDL4|uniprotkb:Q9UNT9|uniprotkb:D3DNL8|ensembl:ENSP00000341382|ensembl:ENSP00000349961	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smc4_human(display_long)|uniprotkb:SMC4(gene name)|psi-mi:SMC4(display_short)|uniprotkb:CAPC(gene name synonym)|uniprotkb:SMC4L1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001002800.1|refseq:NP_005487.3|refseq:XP_011510613.1|refseq:NP_001275682.1|ensembl:ENSG00000113810(gene)|ensembl:ENST00000344722(transcript)|ensembl:ENST00000357388(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q9NTJ3|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853|dip:DIP-32946N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+2lnTSgTXZwRawJ/ASBRa6EDgv09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HC98	intact:EBI-1257113	intact:EBI-740364|uniprotkb:Q96E83|uniprotkb:Q9ULX2|uniprotkb:B7Z2D9|uniprotkb:Q5TBG3|uniprotkb:Q5TBG9|uniprotkb:Q6FG86|uniprotkb:Q6IAR3|ensembl:ENSP00000319734|ensembl:ENSP00000362705|ensembl:ENSP00000441426|ensembl:ENSP00000442636	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nek6_human(display_long)|uniprotkb:Never in mitosis A-related kinase 6(gene name synonym)|uniprotkb:Protein kinase SID6-1512(gene name synonym)|uniprotkb:NEK6(gene name)|psi-mi:NEK6(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001138473.1|refseq:NP_001159639.1|refseq:NP_001159640.1|refseq:NP_001159641.1|refseq:NP_001159642.1|refseq:NP_001159643.1|refseq:NP_055212.2|ensembl:ENSG00000119408(gene)|ensembl:ENST00000320246(transcript)|ensembl:ENST00000373603(transcript)|ensembl:ENST00000545174(transcript)|ensembl:ENST00000546191(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000922"(spindle pole)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-2980767|reactome:R-HSA-3301854|reactome:R-HSA-9648025|refseq:XP_005251721.1|refseq:XP_006716999.1|refseq:XP_016869706.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:khoXzC0KgPfn38NTbXQEgCldfsc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q29RF7	intact:EBI-1257113	intact:EBI-1175454|uniprotkb:Q2TTR5|uniprotkb:Q68DF7|uniprotkb:Q8N7J4|uniprotkb:Q8NG14|uniprotkb:Q9Y4D4|intact:EBI-2554552|ensembl:ENSP00000303427	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pds5a_human(display_long)|uniprotkb:Sister chromatid cohesion protein 112(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 54 protein(gene name synonym)|uniprotkb:PDS5A(gene name)|psi-mi:PDS5A(display_short)|uniprotkb:KIAA0648(gene name synonym)|uniprotkb:PDS5(gene name synonym)|uniprotkb:PIG54(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000121892(gene)|ensembl:ENST00000303538(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039776|mint:Q29RF7|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|go:"GO:0005829"(cytosol)|refseq:NP_001093869.1|refseq:NP_001093870.1|refseq:XP_011511974.1|refseq:XP_016863417.1|dip:DIP-35419N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PaZZmQCIaSIoxVpMuuERQbDLMpY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H1C4	intact:EBI-1257113	intact:EBI-4401271|uniprotkb:O95764|uniprotkb:Q569H6|uniprotkb:Q710D4|ensembl:ENSP00000227471	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:un93b_human(display_long)|uniprotkb:UNC93B1(gene name)|psi-mi:UNC93B1(display_short)|uniprotkb:UNC93(gene name synonym)|uniprotkb:UNC93B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_112192.2|ensembl:ENSG00000110057(gene)|ensembl:ENST00000227471(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR010291(Protein of unknown function DUF895, eukaryotic)|interpro:IPR043268|rcsb pdb:7C76|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-5602415	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KG5h76GZKYHGsRSa+VoDFhbJkOc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H078	intact:EBI-1257113	intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00165	intact:EBI-1257113	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13948	intact:EBI-1257113	intact:EBI-1043463|uniprotkb:Q53GU9|uniprotkb:Q8TBS3|uniprotkb:B3KWH3|uniprotkb:B3KWH8|uniprotkb:B4DZZ2|uniprotkb:G3V1Z6|uniprotkb:J3KPQ6|ensembl:ENSP00000484760|ensembl:ENSP00000292538	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:casp_human(display_long)|uniprotkb:CUTL1(gene name synonym)|uniprotkb:CUX1(gene name)|psi-mi:CUX1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001189473.1|refseq:NP_001189475.1|refseq:NP_001904.2|refseq:NP_852477.1|refseq:NP_001189474.1|ensembl:ENST00000292538(transcript)|ensembl:ENST00000622516(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030173"(integral component of Golgi membrane)|interpro:IPR012955(CASP, C-terminal)|reactome:R-HSA-6811438|ensembl:ENSG00000257923(gene)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wVbRcBsmnWoJ44GcliGkMzhZOFg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43617	intact:EBI-1257113	intact:EBI-743566|uniprotkb:B2RDN2|uniprotkb:D3DPS2|uniprotkb:A6NDN0|ensembl:ENSP00000362261	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tppc3_human(display_long)|uniprotkb:BET3 homolog(gene name synonym)|uniprotkb:TRAPPC3(gene name)|psi-mi:TRAPPC3(display_short)|uniprotkb:BET3(gene name synonym)|uniprotkb:CDABP0066(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055223.1|refseq:NP_001257823.1|refseq:NP_001257824.1|refseq:NP_001257825.1|refseq:NP_001257826.1|ensembl:ENSG00000054116(gene)|ensembl:ENST00000373166(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:0033106"(cis-Golgi network membrane)|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|mint:O43617|rcsb pdb:1SZ7|rcsb pdb:2C0J|rcsb pdb:2CFH|rcsb pdb:3KXC|reactome:R-HSA-204005|reactome:R-HSA-8876198|dip:DIP-47627N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YEQWfs0KIBIDkvJ+2Xtz8afsDCc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00535	intact:EBI-1257113	intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14579	intact:EBI-1257113	intact:EBI-711301|uniprotkb:O76097|ensembl:ENSP00000262812|uniprotkb:Q9UGP6|uniprotkb:Q6IBB8|uniprotkb:A6NKA3|uniprotkb:A6NE29	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cope_human(display_long)|uniprotkb:COPE(gene name)|psi-mi:COPE(display_short)|uniprotkb:Epsilon-coat protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009194.2|ensembl:ENSG00000105669(gene)|ensembl:ENST00000262812(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0099612"(protein localization to axon)|interpro:IPR006822(Coatomer, epsilon subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:O14579|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_955474.1|refseq:NP_955476.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gjrR0x7iNHl/nEDtoZTjThB1dgs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96RQ1	intact:EBI-1257113	intact:EBI-4403663|uniprotkb:A6NHH6|uniprotkb:Q53GY2|uniprotkb:Q8N2Q9|uniprotkb:Q9BVV9|uniprotkb:Q9NZA3|ensembl:ENSP00000353270	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ergi2_human(display_long)|uniprotkb:ERGIC2(gene name)|psi-mi:ERGIC2(display_short)|uniprotkb:ERV41(gene name synonym)|uniprotkb:PTX1(gene name synonym)|uniprotkb:CDA14(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057654.2|ensembl:ENSG00000087502(gene)|ensembl:ENST00000360150(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+T1RODVKNyboKSh3evzH0SZUm7s9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13045	intact:EBI-1257113	intact:EBI-351549|ensembl:ENSP00000491480|ensembl:ENSP00000324573|uniprotkb:B4DIL0|uniprotkb:F5H407|uniprotkb:J3QLG3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:flii_human(display_long)|uniprotkb:FLII(gene name)|psi-mi:FLII(display_short)|uniprotkb:FLIL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002009.1|refseq:NP_001243193.1|ensembl:ENST00000327031(transcript)|ensembl:ENST00000638207(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030239"(myofibril assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR029919|interpro:IPR032675|mint:Q13045|ensembl:ENSG00000177731(gene)|ensembl:ENSG00000284571(gene)|refseq:NP_001243194.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hzls0Ir+lr0+wNsTUeIURV3fXVQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60610	intact:EBI-1257113	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P53618	intact:EBI-1257113	intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q969X5	intact:EBI-1257113	intact:EBI-781527|uniprotkb:Q9H0L0|uniprotkb:Q9H2J2|uniprotkb:Q9ULN9|ensembl:ENSP00000377374	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ergi1_human(display_long)|uniprotkb:ER-Golgi intermediate compartment 32 kDa protein(gene name synonym)|uniprotkb:ERGIC1(gene name)|psi-mi:ERGIC1(display_short)|uniprotkb:KIAA1181(gene name synonym)|uniprotkb:HT034(orf name)|uniprotkb:ERGIC32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006714955.1|refseq:NP_001026881.1|ensembl:ENSG00000113719(gene)|ensembl:ENST00000393784(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UbuPGmvwVwrwg/LT5oAn9pLs5Hw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96CS2	intact:EBI-1257113	intact:EBI-2514791|ensembl:ENSP00000282058|uniprotkb:Q8N837|uniprotkb:B2RDM7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:haus1_human(display_long)|uniprotkb:HAUS1(gene name)|psi-mi:HAUS1(display_short)|uniprotkb:CCDC5(gene name synonym)|uniprotkb:HEIC(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 5(gene name synonym)|uniprotkb:Enhancer of invasion-cluster(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000152240(gene)|ensembl:ENST00000282058(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026243|mint:Q96CS2|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_612452.1|dip:DIP-48835N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:U+lgSilH3iBIHBktPv30KtUnDPg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJX3	intact:EBI-1257113	intact:EBI-1384164|uniprotkb:Q96AC4|uniprotkb:Q96GF4|uniprotkb:Q9BU24|uniprotkb:Q9NT16|ensembl:ENSP00000394394|ensembl:ENSP00000402314	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:apc7_human(display_long)|uniprotkb:ANAPC7(gene name)|psi-mi:ANAPC7(display_short)|uniprotkb:APC7(gene name synonym)|uniprotkb:Cyclosome subunit 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001131136.1|refseq:NP_057322.2|dip:DIP-39765N|ensembl:ENSG00000196510(gene)|ensembl:ENST00000450008(transcript)|ensembl:ENST00000455511(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX3|rcsb pdb:3FFL|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2q+llvuIzK2MOWjPuOUxmyN782E9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJX2	intact:EBI-1257113	intact:EBI-396137|uniprotkb:O75433|uniprotkb:Q9BS73|uniprotkb:B4E3A2|uniprotkb:B7WP05|uniprotkb:Q53FN2|uniprotkb:A8K6E5|uniprotkb:D3DQB7|ensembl:ENSP00000378350	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdc23_human(display_long)|uniprotkb:CDC23(gene name)|psi-mi:CDC23(display_short)|uniprotkb:ANAPC8(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 8(gene name synonym)|uniprotkb:Cyclosome subunit 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004652.2|dip:DIP-32959N|ensembl:ENSG00000094880(gene)|ensembl:ENST00000394886(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR007192(Cdc23)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX2|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:uTZL2UHzZHLoKnio/1LcuSzZpW09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15041	intact:EBI-1257113	intact:EBI-714543|ensembl:ENSP00000306788|uniprotkb:B7Z6S5|uniprotkb:B7Z791|uniprotkb:F5GXP4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ar6p1_human(display_long)|uniprotkb:ARL6IP(gene name synonym)|uniprotkb:ARL6IP1(gene name)|psi-mi:ARL6IP1(display_short)|uniprotkb:KIAA0069(gene name synonym)|uniprotkb:ARMER(gene name synonym)|uniprotkb:Apoptotic regulator in the membrane of the endoplasmic reticulum(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055976.1|ensembl:ENSG00000170540(gene)|ensembl:ENST00000304414(transcript)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|interpro:IPR033301|mint:Q15041|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|refseq:NP_001300787.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3fjkoyvUx25po7xsPcXgpjEeLJg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5X1	intact:EBI-1257113	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P54920	intact:EBI-1257113	intact:EBI-749652|uniprotkb:Q96IK3|uniprotkb:Q9BVJ3|uniprotkb:A8K879|ensembl:ENSP00000263354	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snaa_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein alpha(gene name synonym)|uniprotkb:NAPA(gene name)|psi-mi:NAPA(display_short)|uniprotkb:SNAPA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003818.2|ensembl:ENSG00000105402(gene)|ensembl:ENST00000263354(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007420"(brain development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031201"(SNARE complex)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-HSA-204005|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RHbBvhRSSaakY4HPkl3Y9ggkiPk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63208	intact:EBI-1257113	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BSJ2	intact:EBI-1257113	intact:EBI-357881|uniprotkb:O43632|ensembl:ENSP00000252936|ensembl:ENSP00000506731|ensembl:ENSP00000507482|ensembl:ENSP00000507610|uniprotkb:Q5VWX7|uniprotkb:B4DM18|uniprotkb:F5H4E0|uniprotkb:B7ZKL8|uniprotkb:F5H4L0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gcp2_human(display_long)|uniprotkb:TUBGCP2(gene name)|psi-mi:TUBGCP2(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:Spindle pole body protein Spc97 homolog(gene name synonym)|uniprotkb:Gamma-ring complex protein 103 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006650.1|ensembl:ENSG00000130640(gene)|ensembl:ENST00000252936(transcript)|ensembl:ENST00000682123(transcript)|ensembl:ENST00000682515(transcript)|ensembl:ENST00000683612(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001243547.1|refseq:NP_001243546.1|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q9BSJ2|rcsb pdb:6V6B|rcsb pdb:6V6S|rcsb pdb:6X0V|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vhamYv9ZNsZkSBkGQCwVylqx9wE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99747	intact:EBI-1257113	intact:EBI-3221833|uniprotkb:B4DFC9|ensembl:ENSP00000324628|uniprotkb:Q9BUV1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snag_human(display_long)|uniprotkb:NAPG(gene name)|psi-mi:NAPG(display_short)|uniprotkb:SNAPG(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134265(gene)|ensembl:ENST00000322897(transcript)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0045202"(synapse)|go:"GO:0050821"(protein stabilization)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q99747|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:XP_011524058.1|refseq:NP_003817.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QbHDxqDWn6/UYiMIOMiKfx5eCFg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IUR0	intact:EBI-1257113	intact:EBI-3246160|ensembl:ENSP00000316990|ensembl:ENSP00000399025|ensembl:ENSP00000470262|uniprotkb:A8K7I6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tppc5_human(display_long)|uniprotkb:TRAPPC5(gene name)|psi-mi:TRAPPC5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000181029(gene)|ensembl:ENST00000317378(transcript)|ensembl:ENST00000596148(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:1990070"(TRAPPI protein complex)|go:"GO:1990071"(TRAPPII protein complex)|go:"GO:1990072"(TRAPPIII protein complex)|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")|interpro:IPR016696(TRAPP I complex, Trs31)|interpro:IPR024096|reactome:R-HSA-204005|reactome:R-HSA-8876198|ensembl:ENST00000426877(transcript)|refseq:NP_001035926.1|refseq:NP_001035927.1|refseq:NP_777554.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mojNHWAAx2Vj20UWUjm0UJsHxnQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q68CZ6	intact:EBI-1257113	intact:EBI-2558217|uniprotkb:Q8TAZ5|uniprotkb:O43606|uniprotkb:Q9BTJ9|ensembl:ENSP00000243706|ensembl:ENSP00000500512|ensembl:ENSP00000392903|uniprotkb:B4DF64	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:haus3_human(display_long)|uniprotkb:HAUS3(gene name)|psi-mi:HAUS3(display_short)|uniprotkb:C4orf15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_078787.2|ensembl:ENSG00000214367(gene)|ensembl:ENST00000243706(transcript)|ensembl:ENST00000443786(transcript)|ensembl:ENST00000672739(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:0072686"(mitotic spindle)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026206|interpro:IPR032733|mint:Q68CZ6|rcsb pdb:6PTB|rcsb pdb:6PTE|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_001290072.1|dip:DIP-48832N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gmjepeLf/EVS51MLKnqrcuGniZA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96JB2	intact:EBI-1257113	intact:EBI-2807756|ensembl:ENSP00000258654|uniprotkb:Q5VT70|uniprotkb:B2RAW5|uniprotkb:Q9BZ92|uniprotkb:Q8IXX4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cog3_human(display_long)|uniprotkb:COG3(gene name)|psi-mi:COG3(display_short)|uniprotkb:SEC34(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 3(gene name synonym)|uniprotkb:Vesicle-docking protein SEC34 homolog(gene name synonym)|uniprotkb:p94(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000136152(gene)|ensembl:ENST00000349995(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0050821"(protein stabilization)|interpro:IPR007265(Sec34-like protein)|mint:Q96JB2|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_113619.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:P3sc7TLrhgqNPIh7VYpmsoIhSrE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14757	intact:EBI-1257113	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7Z5G4	intact:EBI-1257113	intact:EBI-4403685|ensembl:ENSP00000350378|ensembl:ENSP00000429329|ensembl:ENSP00000429480|uniprotkb:D3DSX9|uniprotkb:Q96EQ4|uniprotkb:Q9P1S0|uniprotkb:Q9Y5U7|uniprotkb:J3KQ24	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:goga7_human(display_long)|uniprotkb:GOLGA7(gene name)|psi-mi:GOLGA7(display_short)|uniprotkb:GCP16(gene name synonym)|uniprotkb:Golgi complex-associated protein of 16 kDa(gene name synonym)|uniprotkb:HDCKB03P(orf name)|uniprotkb:HSPC041(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000147533(gene)|ensembl:ENST00000357743(transcript)|ensembl:ENST00000518270(transcript)|ensembl:ENST00000520817(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002178"(palmitoyltransferase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005795"(Golgi stack)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0018230"(peptidyl-L-cysteine S-palmitoylation)|go:"GO:0031228"(intrinsic component of Golgi membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR019383|reactome:R-HSA-6798695|reactome:R-HSA-9648002|refseq:NP_001002296.1|refseq:NP_057183.2|refseq:NP_001167595.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NV93lzMDdykrGhl0NkCKYso0t+A9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q93096	intact:EBI-1257113	intact:EBI-1058467|uniprotkb:O00648|uniprotkb:Q49A54|uniprotkb:B2R6C8|intact:EBI-1640492|ensembl:ENSP00000485687|ensembl:ENSP00000497588|ensembl:ENSP00000500859|ensembl:ENSP00000500952	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tp4a1_human(display_long)|uniprotkb:PTP4A1(gene name)|psi-mi:PTP4A1(display_short)|uniprotkb:PRL1(gene name synonym)|uniprotkb:PTPCAAX1(gene name synonym)|uniprotkb:"PTP(CAAXI)"(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 4a1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase of regenerating liver 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003454.1|ensembl:ENSG00000112245(gene)|ensembl:ENST00000626021(transcript)|ensembl:ENST00000648894(transcript)|ensembl:ENST00000672924(transcript)|ensembl:ENST00000673199(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1RXD|rcsb pdb:1XM2|rcsb pdb:5BX1|refseq:XP_016866759.1|refseq:XP_016866760.1|refseq:XP_011534413.1|refseq:XP_011534414.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Eza5NsYNd+5ml6QEEmkQv5pAZ789606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51572	intact:EBI-1257113	intact:EBI-77683|ensembl:ENSP00000343458|ensembl:ENSP00000494052|ensembl:ENSP00000499882|uniprotkb:Q13836|uniprotkb:Q96CF0|uniprotkb:D3DWV5|uniprotkb:B3KQ79	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bap31_human(display_long)|uniprotkb:BCAP31(gene name)|psi-mi:BCAP31(display_short)|uniprotkb:BAP31(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:6C6-AG tumor-associated antigen(gene name synonym)|uniprotkb:DXS1357E(gene name synonym)|uniprotkb:Protein CDM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001132913.1|refseq:NP_005736.3|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904154"(positive regulation of retrograde protein transport, ER to cytosol)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:P51572|rcsb pdb:4JZL|rcsb pdb:4JZP|reactome:R-HSA-111465|reactome:R-HSA-75153|reactome:R-HSA-8980692|reactome:R-HSA-983170|ensembl:ENSG00000185825(gene)|ensembl:ENST00000345046(transcript)|ensembl:ENST00000647529(transcript)|ensembl:ENST00000672675(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001243376.1|refseq:NP_001132929.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m0aN00PLZJDWA/K1vEbla1W9+S89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P06400	intact:EBI-1257113	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NFJ5	intact:EBI-1257113	intact:EBI-2561555|ensembl:ENSP00000014914|uniprotkb:O95357|uniprotkb:B3KV45	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rai3_human(display_long)|uniprotkb:GPRC5A(gene name)|psi-mi:GPRC5A(display_short)|uniprotkb:GPCR5A(gene name synonym)|uniprotkb:RAI3(gene name synonym)|uniprotkb:RAIG1(gene name synonym)|uniprotkb:G-protein coupled receptor family C group 5 member A(gene name synonym)|uniprotkb:Retinoic acid-induced gene 1 protein(gene name synonym)|uniprotkb:Phorbol ester induced gene 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000013588(gene)|ensembl:ENST00000014914(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR017978|refseq:NP_003970.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:34/gAVA1PebkQgzu1veBTClSGcE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27361	intact:EBI-1257113	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16539-2	intact:EBI-1257113	intact:EBI-4403447|ensembl:ENSP00000229795	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q16539-2(display_long)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-73946(isoform-parent)|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229795(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FpUuyu7v2seR6hRNlixYR108O2Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IZP0	intact:EBI-1257113	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P48730	intact:EBI-1257113	intact:EBI-751621|uniprotkb:Q96KZ6|uniprotkb:Q9BTN5|uniprotkb:A2I2P2|ensembl:ENSP00000324464	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kc1d_human(display_long)|uniprotkb:CSNK1D(gene name)|psi-mi:CSNK1D(display_short)|uniprotkb:HCKID(gene name synonym)|uniprotkb:Tau-protein kinase CSNK1D(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001884.2|refseq:NP_620693.1|dip:DIP-39735N|ensembl:ENSG00000141551(gene)|ensembl:ENST00000314028(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48730|rcsb pdb:3UYS|rcsb pdb:3UYT|rcsb pdb:3UZP|rcsb pdb:4HGT|rcsb pdb:4HNF|rcsb pdb:4KB8|rcsb pdb:4KBA|rcsb pdb:4KBC|rcsb pdb:4KBK|rcsb pdb:4TN6|rcsb pdb:4TW9|rcsb pdb:4TWC|rcsb pdb:5IH4|rcsb pdb:5IH5|rcsb pdb:5IH6|rcsb pdb:5MQV|rcsb pdb:5OKT|rcsb pdb:5W4W|rcsb pdb:6F1W|rcsb pdb:6F26|rcsb pdb:6GZM|rcsb pdb:6HMP|rcsb pdb:6HMR|rcsb pdb:6PXN|rcsb pdb:6PXO|rcsb pdb:6PXP|rcsb pdb:6RCG|rcsb pdb:6RCH|rcsb pdb:6RU6|rcsb pdb:6RU7|rcsb pdb:6RU8|reactome:R-HSA-204005|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-400253|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Rz5aON17Bfduv29izmgHa/FR1/49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51692	intact:EBI-1257113	intact:EBI-1186119|uniprotkb:Q8WWS8|ensembl:ENSP00000293328	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sta5b_human(display_long)|uniprotkb:STAT5B(gene name)|psi-mi:STAT5B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036580.2|ensembl:ENSG00000173757(gene)|ensembl:ENST00000293328(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|mint:P51692|rcsb pdb:6MBW|rcsb pdb:6MBZ|reactome:R-HSA-1170546|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ji1JCbmqWFhzMi4yosO5U9t4t0w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95379	intact:EBI-1257113	intact:EBI-1049336|uniprotkb:Q9P1Q1|uniprotkb:Q9UER5|uniprotkb:Q9UP47|uniprotkb:B3KMI2|uniprotkb:B3KMH1|ensembl:ENSP00000421848|ensembl:ENSP00000422245|uniprotkb:B7Z713	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tfip8_human(display_long)|uniprotkb:Head and neck tumor and metastasis-related protein(gene name synonym)|uniprotkb:TNF-induced protein GG2-1(gene name synonym)|uniprotkb:SCC-S2(gene name synonym)|uniprotkb:NF-kappa-B-inducible DED-containing protein(gene name synonym)|uniprotkb:MDC-3.13(gene name synonym)|uniprotkb:TNFAIP8(gene name)|psi-mi:TNFAIP8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001071122.1|refseq:NP_055165.2|refseq:NP_001273742.1|refseq:NP_001273743.1|refseq:NP_001273744.1|refseq:NP_001273746.1|ensembl:ENSG00000145779(gene)|ensembl:ENST00000503646(transcript)|ensembl:ENST00000504771(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR008477(Protein of unknown function DUF758)|interpro:IPR038355|mint:O95379|reactome:R-HSA-1483255	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kU/YcbWj8qTDg4s94mo4j41mT849606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60763	intact:EBI-1257113	intact:EBI-356164|uniprotkb:B2RAQ0|uniprotkb:Q6PK63|uniprotkb:Q8N592|uniprotkb:Q86TB8|ensembl:ENSP00000444850|intact:EBI-21358067	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:uso1_human(display_long)|uniprotkb:USO1(gene name)|psi-mi:USO1(display_short)|uniprotkb:VDP(gene name synonym)|uniprotkb:Protein USO1 homolog(gene name synonym)|uniprotkb:Transcytosis-associated protein(gene name synonym)|uniprotkb:Vesicle-docking protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003706.2|refseq:NP_001276978.1|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|interpro:IPR000225(Armadillo)|interpro:IPR006953(Uso1/p115 like vesicle tethering protein, head region)|interpro:IPR006955(Uso1/p115 like vesicle tethering protein, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR041209|mint:O60763|rcsb pdb:2W3C|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|go:"GO:0061025"(membrane fusion)|ensembl:ENSG00000138768(gene)|ensembl:ENST00000514213(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030133"(transport vesicle)|go:"GO:0032252"(secretory granule localization)|go:"GO:0045056"(transcytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qrBH7A4Ce+01K9Mu8cdVqMYUh4M9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43156	intact:EBI-1257113	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H2K8	intact:EBI-1257113	intact:EBI-1384100|uniprotkb:Q9NZM9|uniprotkb:Q9UHG7|uniprotkb:Q9HC79|uniprotkb:Q658N1|uniprotkb:Q8IUM4|ensembl:ENSP00000376317|ensembl:ENSP00000416374	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:taok3_human(display_long)|uniprotkb:DPK(gene name synonym)|uniprotkb:JIK(gene name synonym)|uniprotkb:KDS(gene name synonym)|uniprotkb:MAP3K18(gene name synonym)|uniprotkb:Thousand and one amino acid protein 3(gene name synonym)|uniprotkb:Jun kinase-inhibitory kinase(gene name synonym)|uniprotkb:JNK/SAPK-inhibitory kinase(gene name synonym)|uniprotkb:Dendritic cell-derived protein kinase(gene name synonym)|uniprotkb:Cutaneous T-cell lymphoma-associated antigen HD-CL-09(gene name synonym)|uniprotkb:Kinase from chicken homolog A(gene name synonym)|uniprotkb:TAOK3(gene name)|psi-mi:TAOK3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057365.3|ensembl:ENSP00000376317|ensembl:ENSP00000416374|refseq:NP_001333417.1|refseq:NP_001333418.1|ensembl:ENSG00000135090(gene)|ensembl:ENST00000392533(transcript)|ensembl:ENST00000419821(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6BDN|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hiCQiP9wMhmpZs8JOcOtP+1w2iE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92542	intact:EBI-1257113	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50148	intact:EBI-1257113	intact:EBI-3909604|uniprotkb:Q6NT27|uniprotkb:Q92471|uniprotkb:O15108|uniprotkb:Q9BZB9|uniprotkb:Q13462|ensembl:ENSP00000286548	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gnaq_human(display_long)|uniprotkb:GNAQ(gene name)|psi-mi:GNAQ(display_short)|uniprotkb:GAQ(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002063.2|ensembl:ENSG00000156052(gene)|ensembl:ENST00000286548(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P50148|rcsb pdb:6VU5|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|dip:DIP-41652N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ExDRSmmaTXllLWSDrc79rkxxAqQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7L9L4	intact:EBI-1257113	intact:EBI-2558745|uniprotkb:B2R8U6|uniprotkb:Q8IY23|ensembl:ENSP00000310189|uniprotkb:B4DRY3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mob1b_human(display_long)|uniprotkb:MOB1B(gene name)|psi-mi:MOB1B(display_short)|uniprotkb:MOB4A(gene name synonym)|uniprotkb:MOBKL1A(gene name synonym)|uniprotkb:Mob1 homolog 1A(gene name synonym)|uniprotkb:Mob1B(gene name synonym)|uniprotkb:Mps one binder kinase activator-like 1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_775739.1|ensembl:ENSG00000173542(gene)|ensembl:ENST00000309395(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703|mint:Q7L9L4|reactome:R-HSA-2028269|refseq:NP_001231695.1|refseq:XP_005265766.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+OqB7l7K1Oax2Aj96idIAas4qT49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y376	intact:EBI-1257113	intact:EBI-306905|ensembl:ENSP00000258418|ensembl:ENSP00000386238|ensembl:ENSP00000386642|uniprotkb:A8K8L7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cab39_human(display_long)|uniprotkb:CAB39(gene name)|psi-mi:CAB39(display_short)|uniprotkb:CGI-66(orf name)|uniprotkb:MO25alpha(gene name synonym)|uniprotkb:MO25(gene name synonym)|uniprotkb:Protein Mo25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902554"(serine/threonine protein kinase complex)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013878(Mo25-like)|go:"GO:0014823"(response to activity)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:1UPK|ensembl:ENSG00000135932(gene)|ensembl:ENST00000258418(transcript)|ensembl:ENST00000409788(transcript)|ensembl:ENST00000410084(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:2WTK|rcsb pdb:3GNI|rcsb pdb:4FZA|rcsb pdb:4FZD|rcsb pdb:4FZF|rcsb pdb:4NZW|rcsb pdb:4O27|reactome:R-HSA-380972|reactome:R-HSA-6798695|rcsb pdb:1UPL|refseq:NP_001124321.1|refseq:NP_001124322.1|refseq:NP_057373.1|dip:DIP-31316N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lexzsGjO9gx4s7ANiX7FrBpg5wc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75676	intact:EBI-1257113	intact:EBI-73933|uniprotkb:O75585|uniprotkb:Q53ES8|uniprotkb:A8K7Z8|ensembl:ENSP00000333896	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ks6a4_human(display_long)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 4(gene name synonym)|uniprotkb:Ribosomal protein kinase B(gene name synonym)|uniprotkb:RPS6KA4(gene name)|psi-mi:RPS6KA4(display_short)|uniprotkb:MSK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001006945.1|refseq:NP_003933.1|refseq:NP_001305290.1|refseq:NP_001287731.1|ensembl:ENSG00000162302(gene)|ensembl:ENST00000334205(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR037714|mint:O75676|reactome:R-HSA-437239	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:C2Zpzuq3c99BNpYuJBozPWc/1DA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P28482	intact:EBI-1257113	intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:odzhd70I/8uWedx0+gF38lhe60I9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62877	intact:EBI-1257113	intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y4R8	intact:EBI-1257113	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49768	intact:EBI-1257113	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75688	intact:EBI-1257113	intact:EBI-1047039|uniprotkb:Q9HAY8|uniprotkb:Q461Q2|uniprotkb:Q658R4|ensembl:ENSP00000282412|uniprotkb:Q96ER6|uniprotkb:Q4J6C1|uniprotkb:Q4J6C2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppm1b_human(display_long)|uniprotkb:Protein phosphatase 2C isoform beta(gene name synonym)|uniprotkb:PPM1B(gene name)|psi-mi:PPM1B(display_short)|uniprotkb:PP2CB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028729.1|refseq:NP_002697.1|refseq:NP_808907.1|refseq:NP_808908.1|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:O75688|rcsb pdb:2P8E|reactome:R-HSA-1169408|ensembl:ENSG00000138032(gene)|ensembl:ENST00000282412(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0016020"(membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cwwfGSSTv9pR/XNLa9UxQ/6hpD89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y2U8	intact:EBI-1257113	intact:EBI-2561428|ensembl:ENSP00000308369|uniprotkb:Q9NT47|uniprotkb:Q9NYA5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:man1_human(display_long)|uniprotkb:MAN1(gene name synonym)|uniprotkb:LEM domain-containing protein 3(gene name synonym)|uniprotkb:LEMD3(gene name)|psi-mi:LEMD3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000174106(gene)|ensembl:ENST00000308330(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:0031965"(nuclear membrane)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018996|interpro:IPR034394|interpro:IPR034997|interpro:IPR035979|interpro:IPR041885|mint:Q9Y2U8|rcsb pdb:2CH0|rcsb pdb:5ZOJ|rcsb pdb:5ZOK|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_001161086.1|refseq:NP_055134.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8AILzxAZLbxCAzlJ7oPg9WybOmY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42224	intact:EBI-1257113	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P19784	intact:EBI-1257113	intact:EBI-347451|ensembl:ENSP00000262506	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P45983	intact:EBI-1257113	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43813	intact:EBI-1257113	intact:EBI-3046631|ensembl:ENSP00000233714|ensembl:ENSP00000388713|ensembl:ENSP00000393323|ensembl:ENSP00000393597|ensembl:ENSP00000397646	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lanc1_human(display_long)|uniprotkb:LANCL1(gene name)|psi-mi:LANCL1(display_short)|uniprotkb:GPR69A(gene name synonym)|uniprotkb:40 kDa erythrocyte membrane protein(gene name synonym)|uniprotkb:LanC-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000115365(gene)|ensembl:ENST00000233714(transcript)|ensembl:ENST00000431941(transcript)|ensembl:ENST00000441020(transcript)|ensembl:ENST00000443314(transcript)|ensembl:ENST00000450366(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043295"(glutathione binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:1903203"(regulation of oxidative stress-induced neuron death)|interpro:IPR007822(Lanthionine synthetase C-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR020464|mint:O43813|rcsb pdb:3E6U|rcsb pdb:3E73|refseq:NP_001130046.1|refseq:NP_001130047.1|refseq:NP_006046.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:em3J/MvBGB1LZ0X1QFagwWBk5FQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P21860	intact:EBI-1257113	intact:EBI-720706|uniprotkb:A8K6L6|uniprotkb:B4DIK7|uniprotkb:B4DV32|uniprotkb:E9PDT8|uniprotkb:Q9BUD7|ensembl:ENSP00000267101	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:erbb3_human(display_long)|uniprotkb:Tyrosine kinase-type cell surface receptor HER3(gene name synonym)|uniprotkb:ERBB3(gene name)|psi-mi:ERBB3(display_short)|uniprotkb:HER3(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001005915.1|refseq:NP_001973.2|ensembl:ENSG00000065361(gene)|ensembl:ENST00000267101(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0021545"(cranial nerve development)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-36441N|reactome:R-HSA-8863795|reactome:R-HSA-9664565|reactome:R-HSA-9665686|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR032778|interpro:IPR036941|mint:P21860|rcsb pdb:1M6B|rcsb pdb:2L9U|rcsb pdb:3KEX|rcsb pdb:3LMG|rcsb pdb:3P11|go:"GO:0042802"(identical protein binding)|rcsb pdb:4P59|rcsb pdb:4RIW|rcsb pdb:4RIX|rcsb pdb:4RIY|rcsb pdb:5CUS|rcsb pdb:5O4O|rcsb pdb:5O7P|rcsb pdb:6KBI|rcsb pdb:6OP9|rcsb pdb:7D85|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|rcsb pdb:4LEO|reactome:R-HSA-8847993	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NlkxlNEYwPOsHrzcGHV0stFbKTA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99720	intact:EBI-1257113	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UBV2	intact:EBI-1257113	intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96D71	intact:EBI-1257113	intact:EBI-1171195|uniprotkb:Q9BXY9|uniprotkb:Q8NDR7|uniprotkb:Q8WU62|uniprotkb:Q5JWJ7|uniprotkb:Q5JWJ5|uniprotkb:Q5JWJ6|uniprotkb:B7ZBZ8|uniprotkb:B7ZBZ9|uniprotkb:B7ZC00|uniprotkb:J3KP76|intact:EBI-28972584|ensembl:ENSP00000392065	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:reps1_human(display_long)|uniprotkb:REPS1(gene name)|psi-mi:REPS1(display_short)|uniprotkb:RalBP1-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273540.1|refseq:NP_001273541.1|ensembl:ENSP00000258062|ensembl:ENST00000367663|ensembl:ENSP00000356635|ensembl:ENST00000409812|ensembl:ENSP00000386699|ensembl:ENSP00000392065|ensembl:ENST00000258062|refseq:NP_001122089.1|refseq:NP_114128.3|ensembl:ENSG00000135597(gene)|ensembl:ENST00000450536(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR026814|mint:Q96D71|reactome:R-HSA-8856825|reactome:R-HSA-8856828	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3MDo2J3yQfEm6X0eRAutKvrg+Fo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q7L7X3	intact:EBI-1257113	intact:EBI-1384314|uniprotkb:Q96L75|uniprotkb:Q9H2K7|uniprotkb:Q9H7S5|uniprotkb:Q9P2I6|uniprotkb:A2RUT8|uniprotkb:B7ZLV6|ensembl:ENSP00000261716	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:taok1_human(display_long)|uniprotkb:Prostate-derived sterile 20-like kinase 2(gene name synonym)|uniprotkb:Thousand and one amino acid protein kinase 1(gene name synonym)|uniprotkb:TAOK1(gene name)|psi-mi:TAOK1(display_short)|uniprotkb:KIAA1361(gene name synonym)|uniprotkb:MAP3K16(gene name synonym)|uniprotkb:MARKK(gene name synonym)|uniprotkb:MARK Kinase(gene name synonym)|uniprotkb:Kinase from chicken homolog B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523362.1|refseq:NP_065842.1|refseq:NP_079418.1|dip:DIP-39709N|ensembl:ENSG00000160551(gene)|ensembl:ENST00000261716(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tfE56A9/KSEBu1lgTyvfrGC9kn89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4A6	intact:EBI-1257113	intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJC3	intact:EBI-1257113	intact:EBI-746704|uniprotkb:O60561|uniprotkb:Q5TG44|uniprotkb:A8MU44|uniprotkb:B4DX15|uniprotkb:A8K8E9|intact:EBI-10969618|ensembl:ENSP00000360252	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hook1_human(display_long)|uniprotkb:HOOK1(gene name)|psi-mi:HOOK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056972.1|ensembl:ENSG00000134709(gene)|ensembl:ENST00000371208(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905198"(manchette assembly)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q9UJC3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QOcYbuKfnNIlNKzos5v+0+A2h3I9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5TC63	intact:EBI-1257113	intact:EBI-4403270|uniprotkb:Q2M232|uniprotkb:Q5TC64|uniprotkb:Q66K26|uniprotkb:Q6P659|uniprotkb:Q8N528|uniprotkb:Q9H695|uniprotkb:B9A6K2|ensembl:ENSP00000364580	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:grtp1_human(display_long)|uniprotkb:GRTP1(gene name)|psi-mi:GRTP1(display_short)|uniprotkb:TBC1D6(gene name synonym)|uniprotkb:TBC1 domain family member 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_078995.2|refseq:NP_001273661.1|refseq:NP_001273662.1|refseq:XP_016876244.1|ensembl:ENSG00000139835(gene)|ensembl:ENST00000375431(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MSFQD3HNn4PSJeBRVM3dXs0z4Wo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UQB8	intact:EBI-1257113	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5W8	intact:EBI-1257113	intact:EBI-3917449|uniprotkb:B2RCI9|uniprotkb:Q8WXH8|uniprotkb:Q8WVZ2|uniprotkb:O94821	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx13_human(display_long)|uniprotkb:SNX13(gene name)|psi-mi:SNX13(display_short)|uniprotkb:KIAA0713(gene name synonym)|uniprotkb:RGS domain- and PHOX domain-containing protein(gene name synonym)|uniprotkb:RGS-PX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR036305|interpro:IPR036871|interpro:IPR037896|refseq:NP_055947.1|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR013937(Sorting nexin, C-terminal)|refseq:XP_005249729.1|go:"GO:0005769"(early endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR037437	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Yyf+DFRzaSwLMeAgcJoPEqAqIhE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P57735	intact:EBI-1257113	intact:EBI-1050500|uniprotkb:Q8NG24|uniprotkb:Q96GB1|uniprotkb:Q5VYA2|uniprotkb:Q9BT12|ensembl:ENSP00000354376	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab25_human(display_long)|uniprotkb:CATX-8(gene name synonym)|uniprotkb:RAB25(gene name)|psi-mi:RAB25(display_short)|uniprotkb:CATX8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065120.2|ensembl:ENSG00000132698(gene)|ensembl:ENST00000361084(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0006887"(exocytosis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0015031"(protein transport)|go:"GO:0031143"(pseudopodium)|go:"GO:0031260"(pseudopodium membrane)|go:"GO:0031268"(pseudopodium organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2OIL|rcsb pdb:3TSO|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2WbrrJ2qe+r96da3nlOIts0RAHY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15286	intact:EBI-1257113	intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8N1B4	intact:EBI-1257113	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P30154	intact:EBI-1257113	intact:EBI-357094|uniprotkb:O75620|uniprotkb:Q8NHV8|uniprotkb:B0YJ69|intact:EBI-2559603|uniprotkb:B4DWW5|uniprotkb:B4DGQ6|uniprotkb:F8W8G1|uniprotkb:A8MY67|uniprotkb:B4DK91|ensembl:ENSP00000437193	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:2aab_human(display_long)|uniprotkb:PPP2R1B(gene name)|psi-mi:PPP2R1B(display_short)|uniprotkb:PP2A subunit A isoform PR65-beta(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-36616N|refseq:NP_001171033.1|refseq:NP_001171034.1|refseq:NP_002707.3|refseq:NP_859050.1|refseq:NP_859051.1|ensembl:ENST00000527614(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:P30154|reactome:R-HSA-113501|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|ensembl:ENSG00000137713(gene)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fYgJ5+zyhLkZTUHV535I4LB+4iw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P43378	intact:EBI-1257113	intact:EBI-742898|ensembl:ENSP00000482732|uniprotkb:Q53XR9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ptn9_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG2(gene name synonym)|uniprotkb:PTPN9(gene name)|psi-mi:PTPN9(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002824.1|ensembl:ENSG00000169410(gene)|ensembl:ENST00000618819(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011074(Phosphatidylinositol transfer protein-like, N-terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036273|interpro:IPR036865|mint:P43378|rcsb pdb:2PA5|rcsb pdb:4GE2|rcsb pdb:4GE5|rcsb pdb:4GE6|rcsb pdb:4ICZ|rcsb pdb:6KZQ|rcsb pdb:6L03|reactome:R-HSA-9008059	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:n4CPv2fRWsJLno+eBY4Kj8K0ylo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11233	intact:EBI-1257113	intact:EBI-1036803|uniprotkb:A4D1W3|ensembl:ENSP00000005257	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rala_human(display_long)|uniprotkb:RAL(gene name synonym)|uniprotkb:RALA(gene name)|psi-mi:RALA(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005393.2|refseq:XP_006715825.1|go:"GO:0019003"(GDP binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051665"(membrane raft localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090543"(Flemming body)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:1UAD|rcsb pdb:1ZC3|rcsb pdb:1ZC4|rcsb pdb:2A78|mint:P11233|rcsb pdb:2A9K|rcsb pdb:2BOV|rcsb pdb:6P0I|rcsb pdb:6P0J|rcsb pdb:6P0K|rcsb pdb:6P0L|rcsb pdb:6P0M|rcsb pdb:6P0N|rcsb pdb:6P0O|reactome:R-HSA-1445148|reactome:R-HSA-171007|reactome:R-HSA-8950505|ensembl:ENSG00000006451(gene)|ensembl:ENST00000005257(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|refseq:XP_011513768.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:41WF1UoYnYZvwC0OPpYwCEqIg2E9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHD8	intact:EBI-1257113	intact:EBI-851542|uniprotkb:Q96QF3|uniprotkb:Q96QF4|uniprotkb:Q96QF5|uniprotkb:Q9HA04|uniprotkb:Q9UG40|uniprotkb:Q9Y5W4|uniprotkb:A8K2V3|uniprotkb:B3KPM0|uniprotkb:B4DTL9|uniprotkb:B4E0N2|uniprotkb:B4E274|uniprotkb:B7Z654|ensembl:ENSP00000391249	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept9_human(display_long)|uniprotkb:SEPTIN9(gene name)|psi-mi:SEPTIN9(display_short)|uniprotkb:KIAA0991(gene name synonym)|uniprotkb:MLL septin-like fusion protein MSF-A(gene name synonym)|uniprotkb:MSF(gene name synonym)|uniprotkb:Ovarian/Breast septin(gene name synonym)|uniprotkb:SEPT9(gene name synonym)|uniprotkb:Septin D1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006721706.1|refseq:XP_006721707.1|refseq:NP_001106963.1|refseq:NP_001106964.1|refseq:NP_001106965.1|refseq:NP_001106966.1|refseq:NP_001106967.1|refseq:NP_001106968.1|refseq:NP_006631.2|refseq:XP_016879520.1|refseq:XP_016879521.1|refseq:NP_001280624.1|refseq:NP_001280625.1|refseq:NP_001280626.1|refseq:NP_001280627.1|refseq:XP_011522509.1|refseq:XP_011522510.1|refseq:XP_005257019.1|dip:DIP-36697N|ensembl:ENSG00000184640(gene)|ensembl:ENST00000427177(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030645|mint:Q9UHD8|rcsb pdb:4YQF|rcsb pdb:5CYO|rcsb pdb:5CYP	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YzUn6hS5tAX/U+SJ8YzqzWW/dQI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61019	intact:EBI-1257113	intact:EBI-752037|uniprotkb:P08886|uniprotkb:B2R5W8|uniprotkb:B4DMQ5|ensembl:ENSP00000262646	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab2a_human(display_long)|uniprotkb:RAB2A(gene name)|psi-mi:RAB2A(display_short)|uniprotkb:RAB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002856.1|refseq:NP_001229573.1|dip:DIP-316N|ensembl:ENSG00000104388(gene)|ensembl:ENST00000262646(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1Z0A|reactome:R-HSA-162658|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MyG011KOkAtsvE2hU/fs21CEe/M9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15019	intact:EBI-1257113	intact:EBI-741220|intact:EBI-28986019|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENSP00000385172|uniprotkb:Q14132|uniprotkb:Q8IUK9|uniprotkb:Q96CB0|uniprotkb:B4DGE8|uniprotkb:Q53QU3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept2_human(display_long)|uniprotkb:SEPTIN2(gene name)|psi-mi:SEPTIN2(display_short)|uniprotkb:DIFF6(gene name synonym)|uniprotkb:KIAA0158(gene name synonym)|uniprotkb:NEDD5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)|uniprotkb:SEPT2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001269901.1|refseq:NP_001269902.1|ensembl:ENSG00000168385(gene)|ensembl:ENST00000360051(transcript)|ensembl:ENST00000391971(transcript)|ensembl:ENST00000391973(transcript)|ensembl:ENST00000402092(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q15019|rcsb pdb:2QA5|rcsb pdb:2QAG|rcsb pdb:2QNR|rcsb pdb:6UPA|rcsb pdb:6UPQ|rcsb pdb:6UPR|reactome:R-HSA-5620912|refseq:NP_001008491.1|refseq:NP_001008492.1|refseq:NP_004395.1|refseq:NP_006146.1|refseq:XP_016859694.1|refseq:XP_016859695.1|refseq:NP_001307958.1|refseq:NP_001307959.1|refseq:NP_001307960.1|refseq:NP_001307961.1|refseq:NP_001307962.1|refseq:NP_001307963.1|refseq:NP_001307964.1|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENST00000401990|ensembl:ENSP00000385109|ensembl:ENSP00000385172|ensembl:ENST00000616972|ensembl:ENSP00000479861|dip:DIP-38220N	-	-	crc64:12CCBBE30806F92F	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H0Us8GtPe2XuXlOYXC0DX79kB/49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NYT0	intact:EBI-1257113	intact:EBI-4289944|uniprotkb:Q96JT0|ensembl:ENSP00000216446	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:plek2_human(display_long)|uniprotkb:PLEK2(gene name)|psi-mi:PLEK2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100558(gene)|ensembl:ENST00000216446(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120034"(positive regulation of plasma membrane bounded cell projection assembly)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037369|rcsb pdb:1X1G|refseq:NP_057529.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h2kivk7G2Zf237nX6S22dhu1uec9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46734	intact:EBI-1257113	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14828	intact:EBI-1257113	intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P54803	intact:EBI-1257113	intact:EBI-4403289|uniprotkb:B4DKE8|uniprotkb:B4DYN1|uniprotkb:B4DZJ8|uniprotkb:B7Z7Z2|uniprotkb:Q8J030|uniprotkb:J3KN25|uniprotkb:J3KPP8|ensembl:ENSP00000261304	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:galc_human(display_long)|uniprotkb:GALC(gene name)|psi-mi:GALC(display_short)|uniprotkb:Galactocerebroside beta-galactosidase(gene name synonym)|uniprotkb:Galactosylceramidase(gene name synonym)|uniprotkb:Galactosylceramide beta-galactosidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000144.2|refseq:NP_001188330.1|refseq:NP_001188331.1|ensembl:ENSG00000054983(gene)|ensembl:ENST00000261304(transcript)|go:"GO:0004336"(galactosylceramidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0043202"(lysosomal lumen)|interpro:IPR001286(Glycoside hydrolase, family 59)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035394|reactome:R-HSA-1660662	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/xO5y1HKJFTahZieRp4GRmTJpkg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BJ8	intact:EBI-1257113	intact:EBI-4400939|uniprotkb:B4DV86|uniprotkb:Q9H8A5|ensembl:ENSP00000377566	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:elmo3_human(display_long)|uniprotkb:ELMO3(gene name)|psi-mi:ELMO3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_078988.2|ensembl:ENSG00000102890(gene)|ensembl:ENST00000393997(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719|go:"GO:0048870"(cell motility)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aZHFb561Oh1Mf14Qe/uuXDDtEp89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50851-2	intact:EBI-1257113	intact:EBI-4403233|ensembl:ENSP00000421552	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p50851-2(display_long)|uniprotkb:LRBA(gene name)|psi-mi:LRBA(display_short)|uniprotkb:BGL(gene name synonym)|uniprotkb:CDC4L(gene name synonym)|uniprotkb:LBA(gene name synonym)|uniprotkb:Beige-like protein(gene name synonym)|uniprotkb:CDC4-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1052167(isoform-parent)|ensembl:ENSG00000198589(gene)|ensembl:ENST00000510413(transcript)|uniprotkb:P50851-2(isoform-parent)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bopBKan6v+YyzEI8fDzkuQUZHUY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5T0N5-3	intact:EBI-1257113	intact:EBI-4403262|ensembl:ENSP00000359275	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q5t0n5-3(display_long)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:C1orf39(gene name synonym)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-714058(isoform-parent)|ensembl:ENSG00000137942(gene)|ensembl:ENST00000370253(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MpFSdw9824VChZs3SiA7/yrwyGE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NSK0	intact:EBI-1257113	intact:EBI-949319|intact:EBI-28986540|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENSP00000418031|uniprotkb:Q66K28|uniprotkb:B3KPI3|uniprotkb:B3KSQ3|uniprotkb:B3KNY4|uniprotkb:B4DME9|uniprotkb:Q96EG6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc4_human(display_long)|uniprotkb:Kinesin-like protein 8(gene name synonym)|uniprotkb:KLC4(gene name)|psi-mi:KLC4(display_short)|uniprotkb:KNSL8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000137171(gene)|ensembl:ENST00000347162(transcript)|ensembl:ENST00000394056(transcript)|ensembl:ENST00000479388(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_612352.1|refseq:NP_958929.1|refseq:NP_958930.1|refseq:NP_958931.1|refseq:NP_001275963.1|refseq:NP_001275964.1|ensembl:ENST00000259708|ensembl:ENSP00000259708|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENST00000453940|ensembl:ENSP00000395806|ensembl:ENST00000458460|ensembl:ENSP00000410358|ensembl:ENST00000467906|ensembl:ENSP00000418759|ensembl:ENSP00000418031	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8wcjm5q5W1xiMTe50m3hpL4jy609606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UEW8	intact:EBI-1257113	intact:EBI-2680974|uniprotkb:Q9UER4|uniprotkb:O14774|uniprotkb:Q53S90|uniprotkb:Q53SL7|uniprotkb:Q53SS1|ensembl:ENSP00000348278|uniprotkb:X5D9C8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stk39_human(display_long)|uniprotkb:SPAK(gene name synonym)|uniprotkb:DCHT(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:STK39(gene name)|psi-mi:STK39(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037365.2|ensembl:ENSG00000198648(gene)|ensembl:ENST00000355999(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:472OT0D4ddZoxjICU4UOhTOJ4Oo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95782	intact:EBI-1257113	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P21359	intact:EBI-1257113	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15036	intact:EBI-1257113	intact:EBI-1752620|uniprotkb:Q53HN7|uniprotkb:Q6IAS3|uniprotkb:B4DQM7|ensembl:ENSP00000233575	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx17_human(display_long)|uniprotkb:SNX17(gene name)|psi-mi:SNX17(display_short)|uniprotkb:KIAA0064(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055563.1|refseq:NP_001253989.1|dip:DIP-52265N|ensembl:ENSG00000115234(gene)|ensembl:ENST00000233575(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035904"(aorta development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR000159(Ras-association)|interpro:IPR001683(Phox-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028666|interpro:IPR036871|interpro:IPR037831|interpro:IPR037836|interpro:IPR040842|rcsb pdb:3FOG|rcsb pdb:4GXB|rcsb pdb:4TKN|rcsb pdb:3LUI	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BDKBliIx7tBTrYK9+l706wdv5P49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50897	intact:EBI-1257113	intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00178	intact:EBI-1257113	intact:EBI-4403245|uniprotkb:Q6IC67|intact:EBI-28983557|ensembl:ENSP00000216044	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gtpb1_human(display_long)|uniprotkb:GTPBP1(gene name)|psi-mi:GTPBP1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004277.2|ensembl:ENSP00000216044|ensembl:ENSG00000100226(gene)|ensembl:ENST00000216044(transcript)|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR035531|interpro:IPR039263	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xgrFwHgoeIjQuqyzXCt0+Y2IQNk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P22059	intact:EBI-1257113	intact:EBI-2681902|uniprotkb:Q6P524|ensembl:ENSP00000263847	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osbp1_human(display_long)|uniprotkb:OSBP1(gene name synonym)|uniprotkb:OSBP(gene name)|psi-mi:OSBP(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002547.1|ensembl:ENSG00000110048(gene)|ensembl:ENST00000263847(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|go:"GO:1904411"(positive regulation of secretory granule organization)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:2RR3|reactome:R-HSA-1660661|reactome:R-HSA-192105|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9LgzhfWQ0E/ECTTKA1OogQSyuAI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UNH7	intact:EBI-1257113	intact:EBI-949294|ensembl:ENSP00000355217|uniprotkb:Q9Y449|uniprotkb:C0H5W9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx6_human(display_long)|uniprotkb:TRAF4-associated factor 2(gene name synonym)|uniprotkb:SNX6(gene name)|psi-mi:SNX6(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000129515(gene)|ensembl:ENST00000362031(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034452"(dynactin binding)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097422"(tubular endosome)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR001683(Phox-like)|interpro:IPR014637(Sorting nexin, Snx5/Snx6 types)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0016241"(regulation of macroautophagy)|interpro:IPR028657|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030904"(retromer complex)|interpro:IPR036871|interpro:IPR042136|mint:Q9UNH7|go:"GO:0030905"(retromer, tubulation complex)|refseq:NP_067072.3|refseq:NP_689419.2|dip:DIP-37549N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:s8v8IGvyXPOBPCxGgtSk42phQdA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UL25	intact:EBI-1257113	intact:EBI-1056039|uniprotkb:Q14466|uniprotkb:Q569H3|ensembl:ENSP00000261263	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab21_human(display_long)|uniprotkb:RAB21(gene name)|psi-mi:RAB21(display_short)|uniprotkb:KIAA0118(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055814.1|ensembl:ENSG00000080371(gene)|ensembl:ENST00000261263(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0005829"(cytosol)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:Q9UL25|rcsb pdb:1YZT|rcsb pdb:1YZU|rcsb pdb:1Z08|rcsb pdb:1Z0I|rcsb pdb:2OT3|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-29349N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xeTabB1AP4LZcYhU4u/vZwwETnA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9C0E2	intact:EBI-1257113	intact:EBI-1044855|uniprotkb:Q5VUZ5|uniprotkb:Q9H934|uniprotkb:Q8N3V6|ensembl:ENSP00000255305	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpo4_human(display_long)|uniprotkb:XPO4(gene name)|psi-mi:XPO4(display_short)|uniprotkb:KIAA1721(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071904.4|ensembl:ENSG00000132953(gene)|ensembl:ENST00000255305(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR044189|mint:Q9C0E2|go:"GO:0005643"(nuclear pore)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+7lQFg9CBnDLFt9rqjLb//HPJnQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6D6	intact:EBI-1257113	intact:EBI-1044254|uniprotkb:Q9NV46|uniprotkb:Q9UFV2|uniprotkb:Q9UNL0|ensembl:ENSP00000262215	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:big1_human(display_long)|uniprotkb:ARFGEF1(gene name)|psi-mi:ARFGEF1(display_short)|uniprotkb:ARFGEP1(gene name synonym)|uniprotkb:BIG1(gene name synonym)|uniprotkb:p200 ARF-GEP1(gene name synonym)|uniprotkb:p200 ARF guanine nucleotide exchange factor(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000066777(gene)|ensembl:ENST00000262215(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007030"(Golgi organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017022"(myosin binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090284"(positive regulation of protein glycosylation in Golgi)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|mint:Q9Y6D6|rcsb pdb:3LTL|rcsb pdb:5EE5|rcsb pdb:5J5C|go:"GO:0051897"(positive regulation of protein kinase B signaling)|refseq:NP_006412.2|refseq:XP_005251191.1|dip:DIP-29748N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HIXdg7zEoEpHcC+KwTUjNFSgr5M9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H9E3	intact:EBI-1257113	intact:EBI-368382|uniprotkb:Q96D40|uniprotkb:Q9BRF0|uniprotkb:Q9BVZ2|uniprotkb:Q9H5Y4|uniprotkb:Q9Y3W3|uniprotkb:B4DMN8|uniprotkb:C9JS23	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cog4_human(display_long)|uniprotkb:COG4(gene name)|psi-mi:COG4(display_short)|uniprotkb:Component of oligomeric Golgi complex 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	mint:Q9H9E3|refseq:NP_001182068.1|refseq:NP_056201.2|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048213"(Golgi vesicle prefusion complex stabilization)|interpro:IPR013167(COG4 transport)|rcsb pdb:3HR0|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|dip:DIP-32635N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Zphojrpw0bzNCK/pnMNps+K1y7U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0U4	intact:EBI-1257113	intact:EBI-1045214|ensembl:ENSP00000310226|uniprotkb:A8K7S1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab1b_human(display_long)|uniprotkb:RAB1B(gene name)|psi-mi:RAB1B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000174903(gene)|ensembl:ENST00000311481(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_112243.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9H0U4|rcsb pdb:3JZA|rcsb pdb:3NKV|rcsb pdb:4HLQ|rcsb pdb:4I1O|rcsb pdb:5O74|rcsb pdb:5SZH|rcsb pdb:5SZK|rcsb pdb:6SKU|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42462N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EI6DHq7xCboSkoqGY5NmVY4Iqf09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51153	intact:EBI-1257113	intact:EBI-1780121|uniprotkb:Q5U0A6|uniprotkb:Q6GPG6|uniprotkb:Q96GU4|uniprotkb:A8K6B5|uniprotkb:D3DV67|ensembl:ENSP00000357564	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab13_human(display_long)|uniprotkb:RAB13(gene name)|psi-mi:RAB13(display_short)|uniprotkb:GIG4(orf name)|uniprotkb:Cell growth-inhibiting gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002861.1|refseq:NP_001258967.1|dip:DIP-40268N|ensembl:ENSG00000143545(gene)|ensembl:ENST00000368575(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51153|reactome:R-HSA-1445148|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XopTW/3AqUPyTi66Nf0HYlkD6Fw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P47712	intact:EBI-1257113	intact:EBI-1044090|uniprotkb:Q29R80|ensembl:ENSP00000356436|uniprotkb:B1AKG4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pa24a_human(display_long)|uniprotkb:PLA2G4A(gene name)|psi-mi:PLA2G4A(display_short)|uniprotkb:CPLA2(gene name synonym)|uniprotkb:PLA2G4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_077734.1|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|rcsb pdb:1BCI|rcsb pdb:1CJY|rcsb pdb:1RLW|reactome:R-HSA-111995|reactome:R-HSA-1482788|reactome:R-HSA-1482798|reactome:R-HSA-1482801|reactome:R-HSA-1482839|reactome:R-HSA-1482922|reactome:R-HSA-1482925|reactome:R-HSA-1483115|reactome:R-HSA-1483166|reactome:R-HSA-2142753|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-6811436|ensembl:ENSG00000116711(gene)|ensembl:ENST00000367466(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0006690"(icosanoid metabolic process)|refseq:NP_001298122.1|refseq:XP_011507944.1|dip:DIP-40991N	-	-	crc64:EE71CA0EBE617856	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:D/yM7EFWP6xaMQ//7wutJS5D3jw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13131	intact:EBI-1257113	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62820	intact:EBI-1257113	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15418	intact:EBI-1257113	intact:EBI-963034|uniprotkb:A6NGG4|intact:EBI-1383804|uniprotkb:A8K9K7|uniprotkb:B7Z5J0|ensembl:ENSP00000363283|ensembl:ENSP00000486881|uniprotkb:Q5SVM5|uniprotkb:Q5SVM8|uniprotkb:Q5SVM9|uniprotkb:Q96C05|uniprotkb:Q9BQK2|uniprotkb:B2RDY8|uniprotkb:E9PRI4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ks6a1_human(display_long)|uniprotkb:RPS6KA1(gene name)|psi-mi:RPS6KA1(display_short)|uniprotkb:RSK1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:MAPKAPK1A(gene name synonym)|uniprotkb:Ribosomal S6 kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000117676(gene)|ensembl:ENSG00000281877(gene)|ensembl:ENST00000374168(transcript)|ensembl:ENST00000629832(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0106311"|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR041906|mint:Q15418|rcsb pdb:2WNT|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|rcsb pdb:2Z7Q|rcsb pdb:2Z7R|rcsb pdb:2Z7S|rcsb pdb:3RNY|go:"GO:0045202"(synapse)|rcsb pdb:3TEI|go:"GO:0045597"(positive regulation of cell differentiation)|rcsb pdb:4H3P|rcsb pdb:4NIF|rcsb pdb:5CSF|rcsb pdb:5CSI|rcsb pdb:5CSJ|rcsb pdb:5CSN|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:6TWY|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|refseq:NP_001006666.1|refseq:NP_002944.2|refseq:NP_001317370.1|dip:DIP-29987N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kx+9PwIH4KR0iTxpv6epDKNqHBE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13561	intact:EBI-1257113	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95747	intact:EBI-1257113	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14185	intact:EBI-1257113	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTJ5	intact:EBI-1257113	intact:EBI-3917235|uniprotkb:B4DK71|uniprotkb:Q7LA14|uniprotkb:A8K527|uniprotkb:Q96AX7|uniprotkb:Q9NQ46|uniprotkb:Q9NQ57|uniprotkb:O94935|uniprotkb:Q7LA22|ensembl:ENSP00000373713|ensembl:ENSP00000500361	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sac1_human(display_long)|uniprotkb:SACM1L(gene name)|psi-mi:SACM1L(display_short)|uniprotkb:KIAA0851(gene name synonym)|uniprotkb:Suppressor of actin mutations 1-like protein(gene name synonym)|uniprotkb:Phosphatidylinositol-4-phosphate phosphatase(gene name synonym)|uniprotkb:SAC1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011531802.1|refseq:NP_054735.3|refseq:NP_001306001.1|refseq:NP_001306002.1|ensembl:ENSG00000211456(gene)|ensembl:ENST00000389061(transcript)|ensembl:ENST00000672477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034593"(phosphatidylinositol bisphosphate phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR002013(Synaptojanin, N-terminal)|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016791"(phosphatase activity)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aaI+D/4SJcwZxWqoxDJ81dA60nU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P48444	intact:EBI-1257113	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14617	intact:EBI-1257113	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P20339	intact:EBI-1257113	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q03519	intact:EBI-1257113	intact:EBI-780781|uniprotkb:Q9UQ83|uniprotkb:O95410|uniprotkb:B0V2J8|uniprotkb:Q53FI6|uniprotkb:Q5HY71|uniprotkb:Q96PT8|ensembl:ENSP00000364032|ensembl:ENSP00000372599|ensembl:ENSP00000372726|ensembl:ENSP00000390013|ensembl:ENSP00000394101	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tap2_human(display_long)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Peptide transporter TAP2(gene name synonym)|uniprotkb:Peptide supply factor 2(gene name synonym)|uniprotkb:Peptide transporter PSF2(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 2(gene name synonym)|uniprotkb:TAP2(gene name)|psi-mi:TAP2(display_short)|uniprotkb:ABCB3(gene name synonym)|uniprotkb:PSF2(gene name synonym)|uniprotkb:RING11(gene name synonym)|uniprotkb:Y1(gene name synonym)|uniprotkb:Really interesting new gene 11 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276972.1|refseq:NP_000535.3|refseq:NP_061313.2|dip:DIP-322N|ensembl:ENSG00000204267(gene)|ensembl:ENSG00000206235(gene)|ensembl:ENSG00000206299(gene)|ensembl:ENSG00000228582(gene)|ensembl:ENSG00000237599(gene)|ensembl:ENST00000374897(transcript)|ensembl:ENST00000383118(transcript)|ensembl:ENST00000383239(transcript)|ensembl:ENST00000419142(transcript)|ensembl:ENST00000443713(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03519|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:w7pDqjoSODoB8qMag1ycxcapvQ09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P11234	intact:EBI-1257113	intact:EBI-752162|uniprotkb:Q53T32|intact:EBI-4324693|uniprotkb:B4E040|uniprotkb:Q6ZS74|ensembl:ENSP00000272519|ensembl:ENSP00000414224	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ralb_human(display_long)|uniprotkb:RALB(gene name)|psi-mi:RALB(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002872.1|refseq:XP_016860111.1|refseq:XP_005263781.1|refseq:XP_005263784.1|refseq:XP_005263785.1|refseq:XP_005263786.1|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:2KE5|rcsb pdb:2KWI|rcsb pdb:6ZQT|rcsb pdb:6ZRN|reactome:R-HSA-171007|ensembl:ENSG00000144118(gene)|ensembl:ENST00000272519(transcript)|ensembl:ENST00000420510(transcript)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:vw59HFSN8liew1tYF7x9fgdeFCU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P2W9	intact:EBI-1257113	intact:EBI-725334|uniprotkb:Q596L3|uniprotkb:Q5TZP5|ensembl:ENSP00000305810	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx18_human(display_long)|uniprotkb:Cell growth-inhibiting gene 9 protein(gene name synonym)|uniprotkb:STX18(gene name)|psi-mi:STX18(display_short)|uniprotkb:GIG9(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_058626.1|refseq:NP_001333211.1|refseq:NP_001333210.1|refseq:NP_001333229.1|ensembl:ENSG00000168818(gene)|ensembl:ENST00000306200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1902117"(positive regulation of organelle assembly)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR019529|mint:Q9P2W9|reactome:R-HSA-6811434|dip:DIP-37617N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QpvkckDM1D5Jaty6AmK3vEwRZts9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43491	intact:EBI-1257113	intact:EBI-1052044|uniprotkb:Q5T4F0|uniprotkb:B4DHI8|uniprotkb:Q68DV2|uniprotkb:E9PPD9|ensembl:ENSP00000338481|ensembl:ENSP00000357110	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:e41l2_human(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:EPB41L2(gene name)|psi-mi:EPB41L2(display_short)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001422.1|refseq:NP_001129026.1|refseq:NP_001129027.1|refseq:NP_001239589.1|refseq:XP_011533832.1|refseq:XP_011533836.1|ensembl:ENSG00000079819(gene)|ensembl:ENST00000337057(transcript)|ensembl:ENST00000368128(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0008091"(spectrin)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O43491|reactome:R-HSA-6794361|refseq:XP_016865844.1|refseq:XP_016865848.1|refseq:XP_016865849.1|refseq:XP_016865850.1|refseq:XP_016865851.1|dip:DIP-17034N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QvhY6g+bBqTBR8oHl/php27Wb7Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63167	intact:EBI-1257113	intact:EBI-349105|uniprotkb:Q15701|ensembl:ENSP00000242577|ensembl:ENSP00000376296|ensembl:ENSP00000376297|ensembl:ENSP00000446614|ensembl:ENSP00000447907	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dyl1_human(display_long)|uniprotkb:DYNLL1(gene name)|psi-mi:DYNLL1(display_short)|uniprotkb:DLC1(gene name synonym)|uniprotkb:DNCLC1(gene name synonym)|uniprotkb:HDLC1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)|uniprotkb:DNCL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001032583.1|refseq:NP_001032584.1|refseq:NP_003737.1|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63167|rcsb pdb:1CMI|rcsb pdb:3ZKE|rcsb pdb:3ZKF|rcsb pdb:6GZJ|rcsb pdb:6GZL|rcsb pdb:6RLB|rcsb pdb:6SC2|rcsb pdb:7D35|reactome:R-HSA-111446|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0060271"(cilium assembly)|go:"GO:0005829"(cytosol)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007286"(spermatid development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|ensembl:ENSG00000088986(gene)|ensembl:ENST00000242577(transcript)|ensembl:ENST00000392508(transcript)|ensembl:ENST00000392509(transcript)|ensembl:ENST00000548342(transcript)|ensembl:ENST00000549989(transcript)|dip:DIP-33150N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv809606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NP72	intact:EBI-1257113	intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NVA2	intact:EBI-1257113	intact:EBI-957999|uniprotkb:Q7L4N1|uniprotkb:Q96SP1|uniprotkb:B7Z7Z6|uniprotkb:Q4W5G1|uniprotkb:Q9UFY9|ensembl:ENSP00000264893|uniprotkb:E9KL32	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sep11_human(display_long)|uniprotkb:SEPTIN11(gene name)|psi-mi:SEPTIN11(display_short)|uniprotkb:SEPT11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060713.1|ensembl:ENSG00000138758(gene)|ensembl:ENST00000264893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:6UPQ|refseq:NP_001293076.1|refseq:XP_016863889.1|dip:DIP-36161N	-	-	crc64:D467F1F315FFD028	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2dJm0WBfPs71hp1nBoMeGF/DR2s9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40222	intact:EBI-1257113	intact:EBI-359793|uniprotkb:Q5TFJ6|uniprotkb:Q66K62|uniprotkb:Q86T54|uniprotkb:Q86T85|uniprotkb:Q86T86|uniprotkb:Q86Y86|uniprotkb:Q86YW3|uniprotkb:Q8N2Y3|uniprotkb:D3DPP6|ensembl:ENSP00000362711|ensembl:ENSP00000362712	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:txlna_human(display_long)|uniprotkb:TXLNA(gene name)|psi-mi:TXLNA(display_short)|uniprotkb:TXLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_787048.1|ensembl:ENSG00000084652(gene)|ensembl:ENST00000373609(transcript)|ensembl:ENST00000373610(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0042113"(B cell activation)|interpro:IPR026183|reactome:R-HSA-449836|refseq:XP_016856051.1|dip:DIP-27612N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:m6McBNTQ5VY4RNUY6PyYTj97YUk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95249	intact:EBI-1257113	intact:EBI-3235244|ensembl:ENSP00000225724|uniprotkb:O75392|uniprotkb:J3KST5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gosr1_human(display_long)|uniprotkb:GOSR1(gene name)|psi-mi:GOSR1(display_short)|uniprotkb:GS28(gene name synonym)|uniprotkb:28 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:28 kDa cis-Golgi SNARE p28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000108587(gene)|ensembl:ENST00000225724(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048209"(regulation of vesicle targeting, to, from or within Golgi)|interpro:IPR023601|mint:O95249|reactome:R-HSA-6807878|reactome:R-HSA-6811438|refseq:NP_001007025.1|refseq:NP_001007026.1|refseq:NP_004862.1|refseq:XP_005258129.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zebOuVPnYg5z3XqCa5rMI2IR/jY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P38606	intact:EBI-1257113	intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P08133	intact:EBI-1257113	intact:EBI-352541|uniprotkb:B7Z8A7|uniprotkb:E9PGK1|uniprotkb:Q6ZT79|uniprotkb:D3DQH4|ensembl:ENSP00000346550	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa6_human(display_long)|uniprotkb:ANXA6(gene name)|psi-mi:ANXA6(display_short)|uniprotkb:ANX6(gene name synonym)|uniprotkb:Annexin-6(gene name synonym)|uniprotkb:Annexin VI(gene name synonym)|uniprotkb:Lipocortin VI(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:p70(gene name synonym)|uniprotkb:Protein III(gene name synonym)|uniprotkb:Chromobindin-20(gene name synonym)|uniprotkb:67 kDa calelectrin(gene name synonym)|uniprotkb:Calphobindin-II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001146.2|refseq:NP_001180473.1|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008289"(lipid binding)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051283"(negative regulation of sequestering of calcium ion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENSG00000197043(gene)|ensembl:ENST00000354546(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003418"(growth plate cartilage chondrocyte differentiation)|interpro:IPR001464(Annexin)|interpro:IPR002393(Annexin, type VI)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|rcsb pdb:1M9I|reactome:R-HSA-445355	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+1oKdgl2a0haedrMSJ8au35MF8c9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60493	intact:EBI-1257113	intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NHP6	intact:EBI-1257113	intact:EBI-2812848|uniprotkb:Q8NA83|uniprotkb:Q8N3H2|ensembl:ENSP00000369860	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mspd2_human(display_long)|uniprotkb:MOSPD2(gene name)|psi-mi:MOSPD2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001170946.1|refseq:NP_689794.1|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0140284"(endoplasmic reticulum-endosome membrane contact site)|interpro:IPR000535(Major sperm protein)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036273|interpro:IPR036865|mint:Q8NHP6|rcsb pdb:6TQS|rcsb pdb:6TQT|rcsb pdb:6TQU|reactome:R-HSA-6798695|reactome:R-HSA-9013405|ensembl:ENSG00000130150(gene)|ensembl:ENST00000380492(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044232"(organelle membrane contact site)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WEdwMYKpu1uQll5NXnMm4P51R4E9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00471	intact:EBI-1257113	intact:EBI-949824|ensembl:ENSP00000484855|uniprotkb:B2R6C5|intact:EBI-10171392|uniprotkb:Q8IW24	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc5_human(display_long)|uniprotkb:Exocyst complex component Sec10(gene name synonym)|uniprotkb:EXOC5(gene name)|psi-mi:EXOC5(display_short)|uniprotkb:SEC10(gene name synonym)|uniprotkb:SEC10L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000070367(gene)|ensembl:ENST00000621441(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904019"(epithelial cell apoptotic process)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR009976(Exocyst complex component Sec10)|interpro:IPR033960|mint:O00471|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_006535.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UaEk0DAH+boE9+hl8z3VUUI78dM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P04062	intact:EBI-1257113	intact:EBI-1564609|uniprotkb:B7Z5G2|uniprotkb:B7Z6S1|uniprotkb:J3KQG4|uniprotkb:J3KQK9|uniprotkb:Q16545|uniprotkb:Q4VX22|uniprotkb:Q6I9R6|uniprotkb:Q9UMJ8|uniprotkb:A8K796|ensembl:ENSP00000314508|ensembl:ENSP00000357357	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:glcm_human(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Alglucerase(gene name synonym)|uniprotkb:Imiglucerase(gene name synonym)|uniprotkb:GBA(gene name)|psi-mi:GBA(display_short)|uniprotkb:GC(gene name synonym)|uniprotkb:GLUC(gene name synonym)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001165282.1|refseq:NP_001165283.1|refseq:NP_000148.2|refseq:NP_001005741.1|refseq:NP_001005742.1|dip:DIP-38645N|ensembl:ENSG00000177628(gene)|ensembl:ENST00000327247(transcript)|ensembl:ENST00000368373(transcript)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007040"(lysosome organization)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P04062|rcsb pdb:1OGS|rcsb pdb:1Y7V|rcsb pdb:2F61|rcsb pdb:2J25|rcsb pdb:2NSX|rcsb pdb:2NT0|rcsb pdb:2NT1|rcsb pdb:2V3D|rcsb pdb:2V3E|rcsb pdb:2V3F|rcsb pdb:2VT0|rcsb pdb:2WCG|rcsb pdb:2WKL|rcsb pdb:2XWD|rcsb pdb:2XWE|rcsb pdb:3GXD|rcsb pdb:3GXF|rcsb pdb:3GXI|rcsb pdb:3GXM|rcsb pdb:3KE0|rcsb pdb:3KEH|rcsb pdb:3RIK|rcsb pdb:3RIL|rcsb pdb:5LVX|rcsb pdb:6MOZ|rcsb pdb:6Q1N|rcsb pdb:6Q1P|rcsb pdb:6Q6K|rcsb pdb:6Q6L|rcsb pdb:6Q6N|rcsb pdb:6TJJ|rcsb pdb:6TJK|rcsb pdb:6TJQ|rcsb pdb:6TN1|rcsb pdb:6YTP|rcsb pdb:6YTR|rcsb pdb:6YUT|rcsb pdb:6YV3|rcsb pdb:6Z39|rcsb pdb:6Z3I|reactome:R-HSA-1660662|reactome:R-HSA-390471	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AWV635bfvuSWV1vflhTcun2riyk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y371	intact:EBI-1257113	intact:EBI-2623095|uniprotkb:Q9H3Z0|uniprotkb:Q9NYA9|uniprotkb:Q9NR47|uniprotkb:Q5H8U5|ensembl:ENSP00000473267|uniprotkb:B4E182	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:shlb1_human(display_long)|uniprotkb:KIAA0491(gene name synonym)|uniprotkb:Bax-interacting factor 1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein B1(gene name synonym)|uniprotkb:CGI-61(orf name)|uniprotkb:SH3GLB1(gene name)|psi-mi:SH3GLB1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193580.1|refseq:NP_001193581.1|refseq:NP_057093.1|go:"GO:0030496"(midbody)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0048102"(autophagic cell death)|go:"GO:0090148"(membrane fission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028503|interpro:IPR035695|interpro:IPR036028|mint:Q9Y371|rcsb pdb:6UP6|rcsb pdb:6UPN|ensembl:ENSG00000097033(gene)|ensembl:ENST00000370558(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016241"(regulation of macroautophagy)|refseq:NP_001193582.1|dip:DIP-41970N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HSs455W45ciZL56fJSPOIvfhUIw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5W7	intact:EBI-1257113	intact:EBI-4401489|uniprotkb:Q6PI37|uniprotkb:Q9BSD1|uniprotkb:B4DI55|uniprotkb:Q4VBR3|uniprotkb:Q5TCF9|uniprotkb:Q5TCG0|uniprotkb:Q6NUI7|ensembl:ENSP00000313121	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx14_human(display_long)|uniprotkb:SNX14(gene name)|psi-mi:SNX14(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065201.1|refseq:NP_722523.1|refseq:NP_001291408.1|refseq:NP_001284543.1|ensembl:ENSG00000135317(gene)|ensembl:ENST00000314673(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036305|interpro:IPR036871|interpro:IPR037436|interpro:IPR037892|rcsb pdb:4BGJ|rcsb pdb:4PQO|rcsb pdb:4PQP	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:a+twl6lGEpR7hRX/P6mYruxJPEw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y3R5	intact:EBI-1257113	intact:EBI-4403087|uniprotkb:D3DSG5|uniprotkb:Q6PJQ7|uniprotkb:Q9UEZ3|ensembl:ENSP00000382104	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dop2_human(display_long)|uniprotkb:DOP1B(gene name)|psi-mi:DOP1B(display_short)|uniprotkb:C21orf5(gene name synonym)|uniprotkb:DOPEY2(gene name synonym)|uniprotkb:KIAA0933(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005119.2|refseq:NP_001307643.1|ensembl:ENSG00000142197(gene)|ensembl:ENST00000399151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007249(Dopey, N-terminal)|interpro:IPR040314	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Xi6Ahb2aiWOCLFMvGusvCKLXtCo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16181	intact:EBI-1257113	intact:EBI-2009373|uniprotkb:Q52M76|uniprotkb:Q6NX50|ensembl:ENSP00000381992	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept7_human(display_long)|uniprotkb:SEPTIN7(gene name)|psi-mi:SEPTIN7(display_short)|uniprotkb:CDC10(gene name synonym)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:SEPT7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001779.3|dip:DIP-47093N|ensembl:ENSG00000122545(gene)|ensembl:ENST00000399034(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR008115(Septin 7)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:2QAG|rcsb pdb:3T5D|rcsb pdb:3TW4|rcsb pdb:6N0B|rcsb pdb:6N12|rcsb pdb:6UQQ|reactome:R-HSA-5687128	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CweIjGLXC7eubvKR7vkkihEkcHg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IWB7	intact:EBI-1257113	intact:EBI-4403108|uniprotkb:Q9H9D5|uniprotkb:Q9P2B3|uniprotkb:Q53S17|ensembl:ENSP00000233055	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wdfy1_human(display_long)|uniprotkb:WDFY1(gene name)|psi-mi:WDFY1(display_short)|uniprotkb:KIAA1435(gene name synonym)|uniprotkb:WDF1(gene name synonym)|uniprotkb:ZFYVE17(gene name synonym)|uniprotkb:Phosphoinositide-binding protein 1(gene name synonym)|uniprotkb:WD40- and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 17(gene name synonym)|uniprotkb:FENS1(gene name synonym)|uniprotkb:FYVE domain-containing protein localized to endosomes 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065881.1|ensembl:ENST00000233055(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR042234|interpro:IPR042733|ensembl:ENSG00000085449(gene)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AoFcP62W/0O/XnJLbAQLFXq7ViA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O94905	intact:EBI-1257113	intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BRK5	intact:EBI-1257113	intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P0L0	intact:EBI-1257113	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q02083	intact:EBI-1257113	intact:EBI-4403065|uniprotkb:Q5KTF2|uniprotkb:Q96EY2|uniprotkb:Q9BRA8|ensembl:ENSP00000286733	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:naaa_human(display_long)|uniprotkb:NAAA(gene name)|psi-mi:NAAA(display_short)|uniprotkb:ASAHL(gene name synonym)|uniprotkb:PLT(gene name synonym)|uniprotkb:Acid ceramidase-like protein(gene name synonym)|uniprotkb:N-acylsphingosine amidohydrolase-like(gene name synonym)|uniprotkb:Acylsphingosine deacylase NAAA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035861.1|refseq:NP_055250.2|refseq:XP_005262977.1|refseq:XP_005262982.1|refseq:XP_016863517.1|ensembl:ENSG00000138744(gene)|ensembl:ENST00000286733(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0017040"(N-acylsphingosine amidohydrolase activity)|go:"GO:0017064"(fatty acid amide hydrolase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0047412"("N-(long-chain-acyl)ethanolamine deacylase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0102121"(ceramidase activity)|interpro:IPR016699(Acid ceramidase-like)|interpro:IPR029130|interpro:IPR029132|rcsb pdb:6DXW|rcsb pdb:6DXX|reactome:R-HSA-112310|go:"GO:0043202"(lysosomal lumen)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:u0EuPni0D2QnyGo4AxOacseoBLs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P253	intact:EBI-1257113	intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15057	intact:EBI-1257113	intact:EBI-4401196|uniprotkb:A8K2V4|uniprotkb:Q8N5Z8|uniprotkb:Q9UQR3|ensembl:ENSP00000324287	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:acap2_human(display_long)|uniprotkb:ACAP2(gene name)|psi-mi:ACAP2(display_short)|uniprotkb:CENTB2(gene name synonym)|uniprotkb:KIAA0041(gene name synonym)|uniprotkb:Centaurin-beta-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036419.3|ensembl:ENSG00000114331(gene)|ensembl:ENST00000326793(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030029"(actin filament-based process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0046872"(metal ion binding)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|rcsb pdb:6IF3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VHSpT12NSofZq3m02WlQNqj1IAQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96QK1	intact:EBI-1257113	intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EXkMduDQKNCdp876vGF5vna9t389606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00499	intact:EBI-1257113	intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60343	intact:EBI-1257113	intact:EBI-522028|uniprotkb:A7E2X8|uniprotkb:B4DU25|uniprotkb:B4E235|uniprotkb:B6ETN8|uniprotkb:B6ETN9|uniprotkb:Q68D14|uniprotkb:Q5W0B9|ensembl:ENSP00000366863	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbcd4_human(display_long)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:TBC1D4(gene name)|psi-mi:TBC1D4(display_short)|uniprotkb:KIAA0603(gene name synonym)|uniprotkb:AS160(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055647.2|ensembl:ENSG00000136111(gene)|ensembl:ENST00000377636(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|refseq:NP_001273587.1|refseq:NP_001273588.1|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021785|interpro:IPR035969|mint:O60343|rcsb pdb:3QYB|rcsb pdb:7NIX|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AfptaRNss/0wnCrivoxs2PgxNOM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BQL6	intact:EBI-1257113	intact:EBI-4403029|uniprotkb:D3DW10|uniprotkb:Q8IX34|uniprotkb:Q8IYH2|uniprotkb:Q9NWM2|uniprotkb:Q9NXQ3|ensembl:ENSP00000217289	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ferm1_human(display_long)|uniprotkb:FERMT1(gene name)|psi-mi:FERMT1(display_short)|uniprotkb:C20orf42(gene name synonym)|uniprotkb:KIND1(gene name synonym)|uniprotkb:URP1(gene name synonym)|uniprotkb:Kindlerin(gene name synonym)|uniprotkb:Kindlin syndrome protein(gene name synonym)|uniprotkb:Kindlin-1(gene name synonym)|uniprotkb:Unc-112-related protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060141.3|ensembl:ENSG00000101311(gene)|ensembl:ENST00000217289(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0051886"(negative regulation of timing of anagen)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037843|interpro:IPR037837|interpro:IPR040790	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lfWyDOEGRWkHX1dFHQ+F1PEukU89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51149	intact:EBI-1257113	intact:EBI-1056089|uniprotkb:A8K3V6|uniprotkb:Q9NWJ0|uniprotkb:Q9UPB0|ensembl:ENSP00000265062|ensembl:ENSP00000501618|ensembl:ENSP00000502000|ensembl:ENSP00000502088|ensembl:ENSP00000502486	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab7a_human(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004628.4|ensembl:ENSG00000075785(gene)|ensembl:ENST00000265062(transcript)|ensembl:ENST00000674589(transcript)|ensembl:ENST00000675342(transcript)|ensembl:ENST00000675497(transcript)|ensembl:ENST00000676214(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1902586"(obsolete multi-organism intercellular transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51149|rcsb pdb:1T91|rcsb pdb:1YHN|rcsb pdb:6IYB|rcsb pdb:6WCW|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9636383|reactome:R-HSA-9636569|rcsb pdb:3LAW|dip:DIP-39879N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96L92	intact:EBI-1257113	intact:EBI-2514865|ensembl:ENSP00000400333|uniprotkb:Q9H3K8|uniprotkb:Q4AEJ5|uniprotkb:Q5VWB0|uniprotkb:Q5VWB2|uniprotkb:Q96D79|uniprotkb:Q5VWB1|uniprotkb:Q32Q36|uniprotkb:Q6IPP6|uniprotkb:Q86UB1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx27_human(display_long)|uniprotkb:SNX27(gene name)|psi-mi:SNX27(display_short)|uniprotkb:KIAA0488(gene name synonym)|uniprotkb:My014(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143376(gene)|ensembl:ENST00000458013(transcript)|go:"GO:0001770"(establishment of natural killer cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|refseq:NP_001317652.1|refseq:NP_112180.4|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|interpro:IPR000159(Ras-association)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|interpro:IPR036034|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q96L92|rcsb pdb:4HAS|rcsb pdb:5ZN9|rcsb pdb:6SAK|interpro:IPR001478(PDZ/DHR/GLGF)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UsAQwtTpOo87fFo6fQJNAZxrFe09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P36543	intact:EBI-1257113	intact:EBI-348639|ensembl:ENSP00000253413|uniprotkb:A8MUE4|uniprotkb:A8MUN4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vate1_human(display_long)|uniprotkb:ATP6V1E1(gene name)|psi-mi:ATP6V1E1(display_short)|uniprotkb:ATP6E(gene name synonym)|uniprotkb:Vacuolar proton pump subunit E 1(gene name synonym)|uniprotkb:V-ATPase 31 kDa subunit(gene name synonym)|uniprotkb:ATP6E2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001687.1|ensembl:ENSG00000131100(gene)|ensembl:ENST00000253413(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002842(ATPase, V1/A1 complex, subunit E)|interpro:IPR038495|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:NP_001034455.1|refseq:NP_001034456.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tTf7Cl6DOsN3USZrmZijWhmhEhg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96JC1	intact:EBI-1257113	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P29323	intact:EBI-1257113	intact:EBI-1059294|uniprotkb:O43477|uniprotkb:Q5T0U6|uniprotkb:Q5T0U7|uniprotkb:Q5T0U8|intact:EBI-1383621|ensembl:ENSP00000383053	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ephb2_human(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:DRT(gene name synonym)|uniprotkb:EPHT3(gene name synonym)|uniprotkb:EPTH3(gene name synonym)|uniprotkb:ERK(gene name synonym)|uniprotkb:HEK5(gene name synonym)|uniprotkb:TYRO5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-47(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO5(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Developmentally-regulated Eph-related tyrosine kinase(gene name synonym)|uniprotkb:ELK-related tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004433.2|refseq:NP_059145.2|refseq:NP_001296122.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|mint:P29323|rcsb pdb:1B4F|rcsb pdb:1F0M|rcsb pdb:3ZFM|reactome:R-HSA-2682334|reactome:R-HSA-373760|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|rcsb pdb:2QBX|ensembl:ENSG00000133216(gene)|ensembl:ENST00000400191(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|go:"GO:0106028"(neuron projection retraction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|dip:DIP-1162N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:be++0VNRygM3NsDcVt/OQ6fHpr09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61619	intact:EBI-1257113	intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5JSP0	intact:EBI-1257113	intact:EBI-4403141|uniprotkb:Q4VX84|uniprotkb:Q7Z7D9|uniprotkb:Q8N5G1|uniprotkb:F8W7P2|ensembl:ENSP00000336914|ensembl:ENSP00000364631|ensembl:ENSP00000496819	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fgd3_human(display_long)|uniprotkb:FGD3(gene name)|psi-mi:FGD3(display_short)|uniprotkb:ZFYVE5(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001077005.1|refseq:NP_149077.2|refseq:NP_001273922.1|refseq:XP_016870763.1|ensembl:ENSG00000127084(gene)|ensembl:ENST00000337352(transcript)|ensembl:ENST00000375482(transcript)|ensembl:ENST00000468206(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035941|rcsb pdb:2COC|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-9013148	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GPfnTNLHRBnUKhWFeaYG7Z6U5xA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15321	intact:EBI-1257113	intact:EBI-1390491|uniprotkb:Q96FI8|uniprotkb:D3DS65|uniprotkb:Q86SZ6|intact:EBI-28976916|ensembl:ENSP00000261789|ensembl:ENSP00000494320	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tm9s1_human(display_long)|uniprotkb:TM9SF1(gene name)|psi-mi:TM9SF1(display_short)|uniprotkb:MP70 protein family member(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001014842.1|refseq:NP_006396.2|ensembl:ENSP00000494320|ensembl:ENSP00000261789|ensembl:ENST00000396854|ensembl:ENSP00000380063|ensembl:ENST00000646500|ensembl:ENSP00000494851|refseq:NP_001275935.1|ensembl:ENSG00000100926(gene)|ensembl:ENSG00000285465(gene)|ensembl:ENST00000261789(transcript)|ensembl:ENST00000646762(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:y4t2+OC3qVXBRLxyH65ywVx8Ja09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NTI5	intact:EBI-1257113	intact:EBI-1175604|uniprotkb:Q5R3S3|uniprotkb:Q5W0K8|uniprotkb:Q6NSC3|uniprotkb:Q8IXT6|uniprotkb:Q9H5N8|uniprotkb:Q9Y2I5|uniprotkb:Q9Y451|intact:EBI-2554539|ensembl:ENSP00000313851	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pds5b_human(display_long)|uniprotkb:Androgen-induced proliferation inhibitor(gene name synonym)|uniprotkb:Androgen-induced prostate proliferative shutoff-associated protein AS3(gene name synonym)|uniprotkb:PDS5B(gene name)|psi-mi:PDS5B(display_short)|uniprotkb:AS3(gene name synonym)|uniprotkb:KIAA0979(gene name synonym)|uniprotkb:APRIN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000083642(gene)|ensembl:ENST00000315596(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039776|mint:Q9NTI5|rcsb pdb:5HDT|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|refseq:NP_055847.1|refseq:XP_016875939.1|dip:DIP-35420N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MOHd5JOiq96RzbEkvMje913OAdQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96AX1	intact:EBI-1257113	intact:EBI-2527283|uniprotkb:Q547V4|uniprotkb:Q9H5Q0|ensembl:ENSP00000267199	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp33a_human(display_long)|uniprotkb:VPS33A(gene name)|psi-mi:VPS33A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000139719(gene)|ensembl:ENST00000267199(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030220"(platelet formation)|go:"GO:0030897"(HOPS complex)|go:"GO:0032400"(melanosome localization)|go:"GO:0032418"(lysosome localization)|go:"GO:0033263"(CORVET complex)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|interpro:IPR043155|mint:Q96AX1|rcsb pdb:4BX8|rcsb pdb:4BX9|go:"GO:0031902"(late endosome membrane)|refseq:NP_075067.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dtPjiiMZ60tlBdhBPrYBHkXAUpE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P60468	intact:EBI-1257113	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O94979	intact:EBI-1257113	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86YS6	intact:EBI-1257113	intact:EBI-4401730|uniprotkb:A8K4P9|uniprotkb:E9PBQ0|ensembl:ENSP00000319781|ensembl:ENSP00000376981|ensembl:ENSP00000376982|ensembl:ENSP00000376984|ensembl:ENSP00000376985	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab43_human(display_long)|uniprotkb:RAB43(gene name)|psi-mi:RAB43(display_short)|uniprotkb:RAB41(gene name synonym)|uniprotkb:Ras-related protein Rab-41(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001191816.1|refseq:NP_001191812.1|refseq:NP_001191813.1|refseq:NP_001191814.1|refseq:NP_001191815.1|refseq:NP_940892.1|ensembl:ENSG00000172780(gene)|ensembl:ENST00000315150(transcript)|ensembl:ENST00000393304(transcript)|ensembl:ENST00000393305(transcript)|ensembl:ENST00000393307(transcript)|ensembl:ENST00000393308(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035526"(retrograde transport, plasma membrane to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090382"(phagosome maturation)|go:"GO:1901998"(toxin transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2HUP|reactome:R-HSA-6811440|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Fnf/WvsSlD/a+UxyrO08zMSjpIo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96KP1	intact:EBI-1257113	intact:EBI-465715|uniprotkb:Q5JPC8|uniprotkb:Q96AN6|uniprotkb:Q9NUZ8|uniprotkb:Q9UJM7|ensembl:ENSP00000230449|uniprotkb:B2RBE6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc2_human(display_long)|uniprotkb:EXOC2(gene name)|psi-mi:EXOC2(display_short)|uniprotkb:SEC5(gene name synonym)|uniprotkb:SEC5L1(gene name synonym)|uniprotkb:Exocyst complex component Sec5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000112685(gene)|ensembl:ENST00000230449(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR029175|interpro:IPR039481|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016866507.1|refseq:XP_016866508.1|refseq:XP_016866509.1|refseq:XP_016866510.1|refseq:XP_016866511.1|refseq:XP_016866512.1|refseq:XP_016866513.1|refseq:NP_060773.3|dip:DIP-31795N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:7p+4vZ18z6u2PJY0GzbHY+ro0v89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BZF1	intact:EBI-1257113	intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62330	intact:EBI-1257113	intact:EBI-638181|uniprotkb:P26438|ensembl:ENSP00000298316|intact:EBI-2802827|uniprotkb:Q6FGZ2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arf6_human(display_long)|uniprotkb:ARF6(gene name)|psi-mi:ARF6(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001654.1|ensembl:ENSG00000165527(gene)|ensembl:ENST00000298316(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|rcsb pdb:1E0S|rcsb pdb:2A5D|rcsb pdb:2A5F|rcsb pdb:2A5G|rcsb pdb:2BAO|rcsb pdb:2BAU|rcsb pdb:2J5X|rcsb pdb:2W83|rcsb pdb:3LVQ|rcsb pdb:3LVR|rcsb pdb:3N5C|rcsb pdb:3PCR|rcsb pdb:4FME|rcsb pdb:4KAX|rcsb pdb:6BBP|rcsb pdb:6BBQ|rcsb pdb:6PAU|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8875656|dip:DIP-33352N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H0B6	intact:EBI-1257113	intact:EBI-726994|ensembl:ENSP00000314837|ensembl:ENSP00000377631|ensembl:ENSP00000399403|uniprotkb:Q9H9C8|uniprotkb:Q9HA20|uniprotkb:B2RDY4|uniprotkb:A8MXL7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc2_human(display_long)|uniprotkb:KLC2(gene name)|psi-mi:KLC2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000174996(gene)|ensembl:ENST00000316924(transcript)|ensembl:ENST00000394067(transcript)|ensembl:ENST00000417856(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0016938"(kinesin I complex)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045296"(cadherin binding)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q9H0B6|rcsb pdb:3CEQ|rcsb pdb:3EDT|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_001128246.1|refseq:NP_001128247.1|refseq:NP_001128248.1|refseq:NP_073733.1|refseq:NP_001305663.1|refseq:XP_005274240.1|dip:DIP-40381N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VjzT5tI182sjUbhjxC1bK9GSMHo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99653	intact:EBI-1257113	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96H20	intact:EBI-1257113	intact:EBI-747719|uniprotkb:Q8IXY3|uniprotkb:Q9UN50|ensembl:ENSP00000421380	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snf8_human(display_long)|uniprotkb:ELL-associated protein of 30 kDa(gene name synonym)|uniprotkb:SNF8(gene name)|psi-mi:SNF8(display_short)|uniprotkb:EAP30(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009172.2|refseq:NP_001304121.1|refseq:NP_001304122.1|refseq:NP_001304123.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016247"(channel regulator activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903772"(regulation of viral budding via host ESCRT complex)|interpro:IPR016689(ESCRT-2 complex, Snf8)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040608|mint:Q96H20|rcsb pdb:2ZME|rcsb pdb:3CUQ|reactome:R-HSA-917729|reactome:R-HSA-9610379|ensembl:ENSG00000159210(gene)|ensembl:ENST00000502492(transcript)|go:"GO:0000814"(ESCRT II complex)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FyjlBpOt9okBFV8Z+g8YLUeyCm49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WU76	intact:EBI-1257113	intact:EBI-2561361|ensembl:ENSP00000384182|uniprotkb:Q8N5F3|uniprotkb:Q96ED3|uniprotkb:Q8N8H0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scfd2_human(display_long)|uniprotkb:SCFD2(gene name)|psi-mi:SCFD2(display_short)|uniprotkb:STXBP1L1(gene name synonym)|uniprotkb:Syntaxin-binding protein 1-like 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000184178(gene)|ensembl:ENST00000401642(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|refseq:NP_689753.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:TaNn58iCMGPAhs6k76eLY0BuGKM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6VEQ5	intact:EBI-1257113	intact:EBI-2870122|intact:EBI-28987462	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wash2_human(display_long)|uniprotkb:WASH2P(gene name)|psi-mi:WASH2P(display_short)|uniprotkb:FAM39B(gene name synonym)|uniprotkb:CXYorf1-like protein on chromosome 2(gene name synonym)|uniprotkb:Protein FAM39B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR021854|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028290|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071203"(WASH complex)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Z6cVOs2syJXIbtDBZ6LM6d/fsew9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRS6	intact:EBI-1257113	intact:EBI-725924|uniprotkb:Q9NRS5|ensembl:ENSP00000366452|uniprotkb:E5KQS6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx15_human(display_long)|uniprotkb:SNX15(gene name)|psi-mi:SNX15(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037438.2|refseq:NP_680086.2|ensembl:ENSG00000110025(gene)|ensembl:ENST00000377244(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001683(Phox-like)|interpro:IPR007330(MIT)|interpro:IPR036181|interpro:IPR036871|mint:Q9NRS6|rcsb pdb:6ECM|rcsb pdb:6MBI	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oN6FG9MC9ZBLy8Q5nkYC4rpPYw89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12846	intact:EBI-1257113	intact:EBI-744942|uniprotkb:Q15525|ensembl:ENSP00000317714|uniprotkb:Q6FHE8|uniprotkb:A8MXY0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-31(gene name synonym)|uniprotkb:STX4(gene name)|psi-mi:STX4(display_short)|uniprotkb:STX4A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000103496(gene)|refseq:NP_004595.2|ensembl:ENST00000313843(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|reactome:R-HSA-114516|reactome:R-HSA-1236974|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-449836|interpro:IPR006011(Syntaxin, N-terminal)|refseq:NP_001259025.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NvOLGIGe/XO2aDPSpdPzrtKniZY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P56962	intact:EBI-1257113	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00161	intact:EBI-1257113	intact:EBI-745000|uniprotkb:O00162|uniprotkb:Q13602|uniprotkb:Q6IAE3|ensembl:ENSP00000249647	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snp23_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-23(gene name synonym)|uniprotkb:SNAP23(gene name)|psi-mi:SNAP23(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003816.2|refseq:NP_570710.1|ensembl:ENSG00000092531(gene)|ensembl:ENST00000249647(transcript)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043005"(neuron projection)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|mint:O00161|rcsb pdb:1NHL|rcsb pdb:3ZUS|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-1236974	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8ZcXbqhusSijGdekDMdkZA5DejY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96IW2	intact:EBI-1257113	intact:EBI-4402781|uniprotkb:Q96NC2|ensembl:ENSP00000446058	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:shd_human(display_long)|uniprotkb:SHD(gene name)|psi-mi:SHD(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_064594.3|ensembl:ENSG00000105251(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|interpro:IPR000980(SH2 motif)|interpro:IPR035039|interpro:IPR035046|interpro:IPR036860|ensembl:ENST00000543264(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:c2PsXxVdBB1dLj+Lu40XdgOb2yY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99570	intact:EBI-1257113	intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CjToF5FvjyANBQtA1wuWQxC82889606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96DR7-3	intact:EBI-1257113	intact:EBI-4402697|ensembl:ENSP00000423295|ensembl:ENSP00000486665	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:q96dr7-3(display_long)|uniprotkb:ARHGEF26(gene name)|psi-mi:ARHGEF26(display_short)|uniprotkb:SGEF(gene name synonym)|uniprotkb:SH3 domain-containing guanine exchange factor(gene name synonym)|uniprotkb:HMFN1864(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-4402573(isoform-parent)|ensembl:ENSG00000114790(gene)|ensembl:ENSG00000277101(gene)|ensembl:ENST00000465817(transcript)|ensembl:ENST00000629129(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2jinOBUP2GkDLbJHdl/wB1/N1Dk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99519	intact:EBI-1257113	intact:EBI-721517|ensembl:ENSP00000229725|ensembl:ENSP00000364782|ensembl:ENSP00000399309|ensembl:ENSP00000401067|ensembl:ENSP00000403720|ensembl:ENSP00000408207|ensembl:ENSP00000408957|ensembl:ENSP00000409489	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:neur1_human(display_long)|uniprotkb:Lysosomal sialidase(gene name synonym)|uniprotkb:N-acetyl-alpha-neuraminidase 1(gene name synonym)|uniprotkb:Acetylneuraminyl hydrolase(gene name synonym)|uniprotkb:G9 sialidase(gene name synonym)|uniprotkb:NEU1(gene name)|psi-mi:NEU1(display_short)|uniprotkb:NANH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000425.1|ensembl:ENSG00000234343(gene)|ensembl:ENSG00000234846(gene)|ensembl:ENSG00000184494(gene)|ensembl:ENSG00000204386(gene)|ensembl:ENSG00000223957(gene)|ensembl:ENSG00000227129(gene)|ensembl:ENSG00000227315(gene)|ensembl:ENSG00000228691(gene)|ensembl:ENST00000229725(transcript)|ensembl:ENST00000375631(transcript)|ensembl:ENST00000411774(transcript)|ensembl:ENST00000422978(transcript)|ensembl:ENST00000423382(transcript)|ensembl:ENST00000434496(transcript)|ensembl:ENST00000437432(transcript)|ensembl:ENST00000439648(transcript)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016997"(alpha-sialidase activity)|go:"GO:0030054"(cell junction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR011040(Neuraminidase)|interpro:IPR026856|interpro:IPR036278|mint:Q99519|reactome:R-HSA-1660662|reactome:R-HSA-4085001|reactome:R-HSA-4341670|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZVyKW74LB/iEd+Ys7Lm7ZyLvv609606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H9H4	intact:EBI-1257113	intact:EBI-4400866|intact:EBI-28975719|ensembl:ENSP00000267202	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp37b_human(display_long)|uniprotkb:VPS37B(gene name)|psi-mi:VPS37B(display_short)|uniprotkb:ESCRT-I complex subunit VPS37B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000267202|refseq:NP_078943.1|ensembl:ENSG00000139722(gene)|ensembl:ENST00000267202(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR029012|interpro:IPR037202|mint:Q9H9H4|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dj398+zsegXf+gk9OiSeZAVlmqk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8N392	intact:EBI-1257113	intact:EBI-372814|uniprotkb:E1P575|uniprotkb:Q58EZ3|uniprotkb:Q6P679|uniprotkb:Q6PJD7|uniprotkb:Q96S64|intact:EBI-28984395|ensembl:ENSP00000357131	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg18_human(display_long)|uniprotkb:Rho-type GTPase-activating protein 18(gene name synonym)|uniprotkb:MacGAP(gene name synonym)|uniprotkb:ARHGAP18(gene name)|psi-mi:ARHGAP18(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_277050.2|ensembl:ENSP00000357131|ensembl:ENSG00000146376(gene)|ensembl:ENST00000368149(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016607"(nuclear speck)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|go:"GO:2000145"(regulation of cell motility)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:24F0Swg/Ye/UfWPt8fJcO+q0nkc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95721	intact:EBI-1257113	intact:EBI-490676|ensembl:ENSP00000215730	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snp29_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-29(gene name synonym)|uniprotkb:Soluble 29 kDa NSF attachment protein(gene name synonym)|uniprotkb:SNAP29(gene name)|psi-mi:SNAP29(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004773.1|ensembl:ENSG00000099940(gene)|ensembl:ENST00000215730(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019905"(syntaxin binding)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061025"(membrane fusion)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|mint:O95721|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-6798695|reactome:R-HSA-6811438|dip:DIP-56475N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:4HyjERPnEDdBgiGt70N9oyrMN1k9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P54619	intact:EBI-1257113	intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00429	intact:EBI-1257113	intact:EBI-724571|uniprotkb:O14541|uniprotkb:O60709|uniprotkb:Q7L6B3|uniprotkb:Q8TBT7|uniprotkb:Q9BWM1|uniprotkb:Q9Y5J2|uniprotkb:B4DSU8|uniprotkb:A8K4X9|ensembl:ENSP00000450399|uniprotkb:B4DGC9|uniprotkb:J3KPI2|uniprotkb:Q59GN9|uniprotkb:G8JLD5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dnm1l_human(display_long)|uniprotkb:Dynamin-like protein(gene name synonym)|uniprotkb:Dnm1p/Vps1p-like protein(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym)|uniprotkb:Dynamin-like protein 4(gene name synonym)|uniprotkb:Dynamin-like protein IV(gene name synonym)|uniprotkb:DNM1L(gene name)|psi-mi:DNM1L(display_short)|uniprotkb:DLP1(gene name synonym)|uniprotkb:DRP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005681.2|refseq:NP_036192.2|refseq:NP_036193.2|ensembl:ENSG00000087470(gene)|ensembl:ENST00000549701(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0016559"(peroxisome fission)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036466"(synaptic vesicle recycling via endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048511"(rhythmic process)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051433"(BH2 domain binding)|go:"GO:0060047"(heart contraction)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070266"(necroptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090149"(mitochondrial membrane fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904579"(cellular response to thapsigargin)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1905395"(response to flavonoid)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR030556|mint:O00429|rcsb pdb:3W6N|rcsb pdb:3W6O|rcsb pdb:3W6P|rcsb pdb:4BEJ|rcsb pdb:4H1U|rcsb pdb:4H1V|rcsb pdb:5WP9|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:1900063"(regulation of peroxisome organization)|reactome:R-HSA-75153|refseq:NP_001265392.1|refseq:NP_001265393.1|refseq:NP_001265394.1|refseq:NP_001265395.1|refseq:NP_001317309.1|dip:DIP-42704N	-	-	crc64:F9521A376B785B71	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hmh7m80FPMdx6/3eUY6l0IK/AqY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P01889	intact:EBI-1257113	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75396	intact:EBI-1257113	intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DRKtD169T9eYZ2kFufLapidvcKs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P00533	intact:EBI-1257113	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P33176	intact:EBI-1257113	intact:EBI-355878|uniprotkb:A0AVB2|uniprotkb:Q5VZ85|ensembl:ENSP00000307078	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kinh_human(display_long)|uniprotkb:KIF5B(gene name)|psi-mi:KIF5B(display_short)|uniprotkb:KNS(gene name synonym)|uniprotkb:KNS1(gene name synonym)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004512.1|ensembl:ENSG00000170759(gene)|ensembl:ENST00000302418(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33176|rcsb pdb:1BG2|rcsb pdb:1MKJ|rcsb pdb:2P4N|rcsb pdb:3J8X|rcsb pdb:3J8Y|rcsb pdb:4HNA|rcsb pdb:4LNU|rcsb pdb:5LT0|rcsb pdb:5LT1|rcsb pdb:5LT2|rcsb pdb:5LT3|rcsb pdb:5LT4|rcsb pdb:6OJQ|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-29244N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2UUVZBn5EAd0xBA5IZDPWHX9i7U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WUH2	intact:EBI-1257113	intact:EBI-2954829|ensembl:ENSP00000258449|ensembl:ENSP00000377027|ensembl:ENSP00000471434|uniprotkb:A8K5R7|uniprotkb:O60466|uniprotkb:D3DVJ8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tgfa1_human(display_long)|uniprotkb:TGFBRAP1(gene name)|psi-mi:TGFBRAP1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0046332"(SMAD binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000135966(gene)|ensembl:ENST00000258449(transcript)|ensembl:ENST00000393359(transcript)|ensembl:ENST00000595531(transcript)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0033263"(CORVET complex)|go:"GO:0034058"(endosomal vesicle fusion)|refseq:NP_001136093.1|refseq:NP_004248.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZW4oCsFmAW4qHQm/AciAtsI3HA49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13470	intact:EBI-1257113	intact:EBI-1383444|uniprotkb:O95364|uniprotkb:Q8IYI4|ensembl:ENSP00000459799|ensembl:ENSP00000491136	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tnk1_human(display_long)|uniprotkb:TNK1(gene name)|psi-mi:TNK1(display_short)|uniprotkb:CD38 negative kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003976.2|refseq:XP_011522347.1|refseq:NP_001238831.1|ensembl:ENSG00000174292(gene)|ensembl:ENSG00000283781(gene)|ensembl:ENST00000576812(transcript)|ensembl:ENST00000639430(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|mint:Q13470	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:PZ5qZxc2A2Ninx9igDperYpLUbc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O94973	intact:EBI-1257113	intact:EBI-1642835|uniprotkb:O75403|uniprotkb:Q96SI8|uniprotkb:Q53ET1|ensembl:ENSP00000413234	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2a2_human(display_long)|uniprotkb:AP2A2(gene name)|psi-mi:AP2A2(display_short)|uniprotkb:ADTAB(gene name synonym)|uniprotkb:CLAPA2(gene name synonym)|uniprotkb:HYPJ(gene name synonym)|uniprotkb:KIAA0899(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Huntingtin-interacting protein J(gene name synonym)|uniprotkb:Huntingtin yeast partner J(gene name synonym)|uniprotkb:HIP9(gene name synonym)|uniprotkb:Huntingtin-interacting protein 9(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001229766.1|refseq:NP_036437.1|ensembl:ENST00000448903(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O94973|reactome:R-HSA-167590|ensembl:ENSG00000183020(gene)|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-6798695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:sda1msOBssgmBiU3ZfSyk3z7/jc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHG3	intact:EBI-1257113	intact:EBI-2908417|ensembl:ENSP00000387654|uniprotkb:B7Z9P8|uniprotkb:B2RB14|uniprotkb:O94982|uniprotkb:Q8N4N5|uniprotkb:Q96QM8	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pcyox_human(display_long)|uniprotkb:PCYOX1(gene name)|psi-mi:PCYOX1(display_short)|uniprotkb:KIAA0908(gene name synonym)|uniprotkb:PCL1(gene name synonym)|uniprotkb:Prenylcysteine lyase(gene name synonym)|uniprotkb:UNQ597/PRO1183(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000116005(gene)|ensembl:ENST00000433351(transcript)|go:"GO:0001735"(prenylcysteine oxidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0030327"(prenylated protein catabolic process)|go:"GO:0030328"(prenylcysteine catabolic process)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR010795(Prenylcysteine lyase)|interpro:IPR017046(Prenylcysteine oxidase)|interpro:IPR036188|mint:Q9UHG3|refseq:NP_057381.3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:E7WR6qZZuoGqmWQ+CX6PeZX/yEw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43592	intact:EBI-1257113	intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95219	intact:EBI-1257113	intact:EBI-724909|uniprotkb:D3DNA3|uniprotkb:B4DQV4|uniprotkb:B3KMH0|ensembl:ENSP00000251775	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx4_human(display_long)|uniprotkb:SNX4(gene name)|psi-mi:SNX4(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003785.1|ensembl:ENSG00000114520(gene)|ensembl:ENST00000251775(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR027267|interpro:IPR034783|interpro:IPR034902|interpro:IPR036871|interpro:IPR037430|dip:DIP-36719N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Y/Dg8VrUYYvI5Xf67D3unhCjLDA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63010	intact:EBI-1257113	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13596	intact:EBI-1257113	intact:EBI-2822329|uniprotkb:O60750|uniprotkb:A8K6T7|uniprotkb:A6NM19|uniprotkb:O60751|uniprotkb:H0Y2M5|uniprotkb:Q6ZRJ8|ensembl:ENSP00000453785	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx1_human(display_long)|uniprotkb:SNX1(gene name)|psi-mi:SNX1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003090.2|refseq:NP_683758.1|refseq:NP_001229862.1|ensembl:ENSG00000028528(gene)|ensembl:ENST00000559844(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028660|interpro:IPR034901|mint:Q13596|rcsb pdb:2I4K|rcsb pdb:4FZS|interpro:IPR036871|dip:DIP-398N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:nFyxCtQ9gHndLbuCjBiwhyWE5do9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4M9	intact:EBI-1257113	intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13485	intact:EBI-1257113	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:A0A140T921	intact:EBI-1257113	intact:EBI-4403368|ensembl:ENSP00000389248	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:a0a140t921_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A2ABE5(uniprot-removed-ac)|ensembl:ENSG00000233841(gene)|ensembl:ENST00000422726(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ZqJ8ZywuXdhqNh5mtll0dce0AE49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14764	intact:EBI-1257113	intact:EBI-2816254|uniprotkb:Q9BPW6|uniprotkb:Q9BQT1|uniprotkb:Q96BG4|uniprotkb:Q9UBD1|intact:EBI-28971732|ensembl:ENSP00000349977|ensembl:ENSP00000378760	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mvp_human(display_long)|uniprotkb:MVP(gene name)|psi-mi:MVP(display_short)|uniprotkb:LRP(gene name synonym)|uniprotkb:Lung resistance-related protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000349977|ensembl:ENSP00000378760|refseq:NP_001280133.1|refseq:NP_001280134.1|refseq:NP_005106.2|refseq:NP_059447.2|ensembl:ENSG00000013364(gene)|ensembl:ENST00000357402(transcript)|ensembl:ENST00000395353(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|mint:Q14764|rcsb pdb:1Y7X|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/Hc6TeTzO5QSpZ8AUXiI2ox4eg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NPQ8	intact:EBI-1257113	intact:EBI-717509|uniprotkb:Q0P508|uniprotkb:Q2T9J1|uniprotkb:Q7Z352|uniprotkb:Q96EZ1|uniprotkb:Q96SZ2|uniprotkb:Q9H064|uniprotkb:Q9H5H3|uniprotkb:Q9H9E7|ensembl:ENSP00000432008	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ric8a_human(display_long)|uniprotkb:Protein Ric-8A(gene name synonym)|uniprotkb:RIC8A(gene name)|psi-mi:RIC8A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273063.1|refseq:NP_068751.4|refseq:XP_016873596.1|ensembl:ENSG00000177963(gene)|ensembl:ENST00000526104(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0070586"(cell-cell adhesion involved in gastrulation)|go:"GO:0071711"(basement membrane organization)|interpro:IPR008376(Synembryn)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019318|mint:Q9NPQ8|go:"GO:0001965"(G-protein alpha-subunit binding)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jNCxRLnDY2aSw6SMtE82Tny1IE89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H223	intact:EBI-1257113	intact:EBI-1050573|uniprotkb:Q9HAR1|uniprotkb:Q9NZN2|ensembl:ENSP00000220325	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ehd4_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated protein 10/11(gene name synonym)|uniprotkb:EHD4(gene name)|psi-mi:EHD4(display_short)|uniprotkb:HCA10(gene name synonym)|uniprotkb:HCA11(gene name synonym)|uniprotkb:FKSG7(orf name)|uniprotkb:PAST4(gene name synonym)|uniprotkb:PAST homolog 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_644670.1|ensembl:ENSG00000103966(gene)|ensembl:ENST00000220325(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029952|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H223	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WtFn0GamyqosWQvcBXdhbtjJ3Fw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P49841	intact:EBI-1257113	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00203	intact:EBI-1257113	intact:EBI-1044383|ensembl:ENSP00000255194|uniprotkb:O00580|uniprotkb:Q7Z393|uniprotkb:Q9HD66|uniprotkb:E5RJ68|intact:EBI-10969499	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap3b1_human(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:AP3B1(gene name)|psi-mi:AP3B1(display_short)|uniprotkb:ADTB3A(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:O00203|reactome:R-HSA-432722|reactome:R-HSA-6802952|refseq:NP_003655.3|ensembl:ENSG00000132842(gene)|ensembl:ENST00000255194(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|refseq:NP_001258698.1|dip:DIP-24208N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+06UuQo62p9ALS7DiX+yKg7YRyg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y3L3	intact:EBI-1257113	intact:EBI-346869|uniprotkb:Q5R3N0|uniprotkb:Q6IBZ2|uniprotkb:Q6ZVL9|uniprotkb:Q96HQ5|uniprotkb:Q9NSQ9|ensembl:ENSP00000497104	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:3bp1_human(display_long)|uniprotkb:SH3BP1(gene name)|psi-mi:SH3BP1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061830.3|ensembl:ENSG00000100092(gene)|ensembl:ENST00000649765(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|mint:Q9Y3L3|rcsb pdb:4J9D|rcsb pdb:4J9F|reactome:R-HSA-9013149	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FLnCGJhsS+syrKyjVQG4Q6UcZeU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P40763	intact:EBI-1257113	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UJZ1	intact:EBI-1257113	intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61006	intact:EBI-1257113	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13263	intact:EBI-1257113	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UHA4	intact:EBI-1257113	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60749	intact:EBI-1257113	intact:EBI-1046690|uniprotkb:O43650|uniprotkb:P82862|uniprotkb:Q53XK8|uniprotkb:Q597H6|uniprotkb:Q9BTS8|ensembl:ENSP00000368831|uniprotkb:B3KN44|uniprotkb:B4DEK4|uniprotkb:B7Z408	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx2_human(display_long)|uniprotkb:Transformation-related gene 9 protein(gene name synonym)|uniprotkb:SNX2(gene name)|psi-mi:SNX2(display_short)|uniprotkb:TRG9(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003091.2|ensembl:ENSG00000205302(gene)|ensembl:ENST00000379516(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028653|interpro:IPR037918|mint:O60749|interpro:IPR036871|reactome:R-HSA-432722|refseq:NP_001265128.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Sb/i4ZNGqy+ixeexnp0/4uOo3jo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q53EL6	intact:EBI-1257113	intact:EBI-935824|uniprotkb:O15501|uniprotkb:Q5VZS6|uniprotkb:Q6PJI5|uniprotkb:Q8TAR5|uniprotkb:Q99834|intact:EBI-2514227|uniprotkb:B2RCV4|uniprotkb:B5ME91|ensembl:ENSP00000280154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pdcd4_human(display_long)|uniprotkb:PDCD4(gene name)|psi-mi:PDCD4(display_short)|uniprotkb:H731(gene name synonym)|uniprotkb:Nuclear antigen H731-like(gene name synonym)|uniprotkb:Neoplastic transformation inhibitor protein(gene name synonym)|uniprotkb:Protein 197/15a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055271.2|refseq:NP_663314.1|dip:DIP-29756N|ensembl:ENSG00000150593(gene)|ensembl:ENST00000280154(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007569"(cell aging)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039778|rcsb pdb:2GGF|rcsb pdb:2KZT|rcsb pdb:2RG8|rcsb pdb:2ZU6|rcsb pdb:3EIJ|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kkqDk2CCFvHpSCKNDzV4wqSm1HE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q07666	intact:EBI-1257113	intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61020	intact:EBI-1257113	intact:EBI-399401|uniprotkb:P35239|uniprotkb:P35277|uniprotkb:Q6PIK9|uniprotkb:Q86TH0|uniprotkb:Q8IXL2|uniprotkb:A8K982|uniprotkb:B4DKD7|ensembl:ENSP00000353444|ensembl:ENSP00000450168	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab5b_human(display_long)|uniprotkb:RAB5B(gene name)|psi-mi:RAB5B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002859.1|refseq:NP_001238965.1|refseq:XP_005269108.1|refseq:XP_005269109.1|refseq:NP_001238966.1|ensembl:ENSG00000111540(gene)|ensembl:ENST00000360299(transcript)|ensembl:ENST00000553116(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2HEI|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jm+x3SYDL+i+/BrDFnp44kxlHUM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y6D5	intact:EBI-1257113	intact:EBI-2837511|uniprotkb:Q9NTS1|uniprotkb:Q5TFT9|ensembl:ENSP00000360985	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:big2_human(display_long)|uniprotkb:ARFGEF2(gene name)|psi-mi:ARFGEF2(display_short)|uniprotkb:ARFGEP2(gene name synonym)|uniprotkb:BIG2(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006411.2|ensembl:ENSG00000124198(gene)|ensembl:ENST00000371917(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005879"(axonemal microtubule)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0055037"(recycling endosome)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|rcsb pdb:3L8N|rcsb pdb:3SWV|reactome:R-HSA-390471|go:"GO:0005794"(Golgi apparatus)|dip:DIP-48794N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:y64XGrD2XxX6vTmWOW0hbjDzDCk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q5T9L3	intact:EBI-1257113	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96T51	intact:EBI-1257113	intact:EBI-3941207|uniprotkb:Q71S93|uniprotkb:Q9H6I3|uniprotkb:Q59FF3|ensembl:ENSP00000325594|ensembl:ENSP00000492748	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rufy1_human(display_long)|uniprotkb:RUFY1(gene name)|psi-mi:RUFY1(display_short)|uniprotkb:RABIP4(gene name synonym)|uniprotkb:ZFYVE12(gene name synonym)|uniprotkb:FYVE-finger protein EIP1(gene name synonym)|uniprotkb:La-binding protein 1(gene name synonym)|uniprotkb:Rab4-interacting protein(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000176783(gene)|ensembl:ENSG00000284260(gene)|ensembl:ENST00000319449(transcript)|ensembl:ENST00000639909(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004012(RUN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR037213|mint:Q96T51|rcsb pdb:2YQM|rcsb pdb:2YW8|reactome:R-HSA-1660499|refseq:NP_001035541.1|refseq:NP_001035542.1|refseq:NP_079434.3|refseq:XP_016865384.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3NpobaRRj+FMI5fgYLEL6iy3T0w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UPT5	intact:EBI-1257113	intact:EBI-720048|uniprotkb:Q96FF0|uniprotkb:Q9H8C3|uniprotkb:Q9H9X3|uniprotkb:Q9HA32|uniprotkb:Q8ND93|uniprotkb:Q8WV91|uniprotkb:B5MC69|uniprotkb:B8XXP2|ensembl:ENSP00000334100	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc7_human(display_long)|uniprotkb:EXOC7(gene name)|psi-mi:EXOC7(display_short)|uniprotkb:EXO70(gene name synonym)|uniprotkb:KIAA1067(gene name synonym)|uniprotkb:Exocyst complex component Exo70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001013861.1|refseq:NP_001138769.1|refseq:NP_001138770.1|refseq:NP_001138771.1|refseq:NP_056034.2|ensembl:ENSG00000182473(gene)|ensembl:ENST00000335146(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032584"(growth cone membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR004140(Exo70 exocyst complex subunit)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UPT5|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_001269242.1|dip:DIP-37604N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f/uwscxIcAuG96QZzNMQtrzTmeU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5X3	intact:EBI-1257113	intact:EBI-715760|uniprotkb:Q52LC4|uniprotkb:B7ZKN3|uniprotkb:Q9BWP0|uniprotkb:Q7KZN0|uniprotkb:D3DW26|ensembl:ENSP00000366988|ensembl:ENSP00000366998	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx5_human(display_long)|uniprotkb:SNX5(gene name)|psi-mi:SNX5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055241.1|refseq:NP_689413.1|ensembl:ENSG00000089006(gene)|ensembl:ENST00000377759(transcript)|ensembl:ENST00000377768(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006907"(pinocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034452"(dynactin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070685"(macropinocytic cup)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097422"(tubular endosome)|interpro:IPR001683(Phox-like)|interpro:IPR014637(Sorting nexin, Snx5/Snx6 types)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028654|interpro:IPR036871|interpro:IPR042135|mint:Q9Y5X3|rcsb pdb:1SYS|rcsb pdb:5TGH|rcsb pdb:5TGI|rcsb pdb:5TGJ|rcsb pdb:5WY2|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6N5Z|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VR2oUxQ4M2bm5zKeHQlao046QL09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UIA9	intact:EBI-1257113	intact:EBI-286668|uniprotkb:O94846|uniprotkb:Q6PJK9|uniprotkb:Q8NEK7|ensembl:ENSP00000252512	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:xpo7_human(display_long)|uniprotkb:Ran-binding protein 16(gene name synonym)|uniprotkb:XPO7(gene name)|psi-mi:XPO7(display_short)|uniprotkb:KIAA0745(gene name synonym)|uniprotkb:RANBP16(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055839.3|ensembl:ENSG00000130227(gene)|ensembl:ENST00000252512(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040021|interpro:IPR044189|mint:Q9UIA9	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:v+DQUTgId55XuRlCPZ4tq7fIing9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P42345	intact:EBI-1257113	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O76027	intact:EBI-1257113	intact:EBI-720960|ensembl:ENSP00000357943|uniprotkb:Q5SZF1|uniprotkb:Q6FI55|uniprotkb:Q9BS00|uniprotkb:Q9HBJ6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anxa9_human(display_long)|uniprotkb:Annexin-9(gene name synonym)|uniprotkb:Annexin-31(gene name synonym)|uniprotkb:Annexin XXXI(gene name synonym)|uniprotkb:Pemphaxin(gene name synonym)|uniprotkb:ANXA9(gene name)|psi-mi:ANXA9(display_short)|uniprotkb:ANX31(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143412(gene)|ensembl:ENST00000368947(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0045202"(synapse)|refseq:NP_003559.2|go:"GO:0046790"(virion binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001464(Annexin)|interpro:IPR009116(Annexin, type XXXI)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2fjaN8KglkfcnlwfB/hEy3yt8ag9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q07960	intact:EBI-1257113	intact:EBI-602762|uniprotkb:D3DQQ6|ensembl:ENSP00000310491	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg01_human(display_long)|uniprotkb:Rho-type GTPase-activating protein 1(gene name synonym)|uniprotkb:Rho-related small GTPase protein activator(gene name synonym)|uniprotkb:p50-RhoGAP(gene name synonym)|uniprotkb:CDC42 GTPase-activating protein(gene name synonym)|uniprotkb:ARHGAP1(gene name)|psi-mi:ARHGAP1(display_short)|uniprotkb:CDC42GAP(gene name synonym)|uniprotkb:RHOGAP1(gene name synonym)|uniprotkb:GTPase-activating protein rhoGAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004299.1|refseq:XP_011518397.1|dip:DIP-6081N|ensembl:ENSG00000175220(gene)|ensembl:ENST00000311956(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001136"(negative regulation of endocytic recycling)|interpro:IPR000198(RhoGAP)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036865|mint:Q07960|rcsb pdb:1AM4|rcsb pdb:1GRN|rcsb pdb:1OW3|rcsb pdb:1RGP|rcsb pdb:1TX4|rcsb pdb:2NGR|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:6R3V|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9696270	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ceA3oLsnddhLiSbylS89P64mYBo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92574	intact:EBI-1257113	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96A65	intact:EBI-1257113	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q53H12	intact:EBI-1257113	intact:EBI-2269837|uniprotkb:Q75KN1|uniprotkb:Q96GC3|uniprotkb:Q9NP48|ensembl:ENSP00000496789|ensembl:ENSP00000497280|ensembl:ENSP00000498112|ensembl:ENSP00000458417	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:agk_human(display_long)|uniprotkb:AGK(gene name)|psi-mi:AGK(display_short)|uniprotkb:MULK(gene name synonym)|uniprotkb:Multiple substrate lipid kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514699.1|refseq:NP_060708.1|ensembl:ENSG00000006530(gene)|ensembl:ENST00000575872(transcript)|ensembl:ENST00000648068(transcript)|ensembl:ENST00000649286(transcript)|ensembl:ENST00000650547(transcript)|go:"GO:0001727"(lipid kinase activity)|go:"GO:0001729"(ceramide kinase activity)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042721"(TIM22 mitochondrial import inner membrane insertion complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0047620"(acylglycerol kinase activity)|go:"GO:0102773"(dihydroceramide kinase activity)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|go:"GO:0005743"(mitochondrial inner membrane)|ensembl:ENSG00000262327(gene)|rcsb pdb:7CGP|reactome:R-HSA-1483206|reactome:R-HSA-6802952|mint:Q53H12	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:aUz/aYnkviiUE/ijNEddfOQmjZQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P45985	intact:EBI-1257113	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P78527	intact:EBI-1257113	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60664	intact:EBI-1257113	intact:EBI-725795|uniprotkb:Q53G77|uniprotkb:Q9BS03|uniprotkb:Q9UBD7|uniprotkb:Q9UP92|uniprotkb:A8K4Y9|intact:EBI-11103673|uniprotkb:K7EQF4|ensembl:ENSP00000221957	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:plin3_human(display_long)|uniprotkb:Cargo selection protein TIP47(gene name synonym)|uniprotkb:47 kDa mannose 6-phosphate receptor-binding protein(gene name synonym)|uniprotkb:Placental protein 17(gene name synonym)|uniprotkb:PLIN3(gene name)|psi-mi:PLIN3(display_short)|uniprotkb:TIP47(gene name synonym)|uniprotkb:M6PRBP1(gene name synonym)|uniprotkb:Mannose-6-phosphate receptor-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001157666.1|refseq:NP_001157661.1|refseq:NP_005808.3|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019915"(lipid storage)|go:"GO:0030133"(transport vesicle)|ensembl:ENSG00000105355(gene)|go:"GO:0045296"(cadherin binding)|interpro:IPR004279(Perilipin)|reactome:R-HSA-163560|reactome:R-HSA-6811440|reactome:R-HSA-9613354|ensembl:ENST00000221957(transcript)|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:U+skqZ/oQtQscaEvfdh+AVnCCKA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q05397	intact:EBI-1257113	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q03518	intact:EBI-1257113	intact:EBI-747259|uniprotkb:Q16149|intact:EBI-780739|uniprotkb:Q96CP4|ensembl:ENSP00000346206|ensembl:ENSP00000372722|ensembl:ENSP00000401149|ensembl:ENSP00000402316|ensembl:ENSP00000405356|ensembl:ENSP00000413080|ensembl:ENSP00000415660	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tap1_human(display_long)|uniprotkb:ABCB2(gene name synonym)|uniprotkb:PSF1(gene name synonym)|uniprotkb:RING4(gene name synonym)|uniprotkb:Y3(gene name synonym)|uniprotkb:TAP1(gene name)|psi-mi:TAP1(display_short)|uniprotkb:Peptide transporter TAP1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 2(gene name synonym)|uniprotkb:Peptide supply factor 1(gene name synonym)|uniprotkb:Peptide transporter PSF1(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 1(gene name synonym)|uniprotkb:Really interesting new gene 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000584.2|refseq:NP_001278951.1|ensembl:ENSG00000168394(gene)|ensembl:ENSG00000206297(gene)|ensembl:ENSG00000224212(gene)|ensembl:ENSG00000226173(gene)|ensembl:ENSG00000227816(gene)|ensembl:ENSG00000230705(gene)|ensembl:ENSG00000232367(gene)|ensembl:ENST00000354258(transcript)|ensembl:ENST00000383235(transcript)|ensembl:ENST00000414467(transcript)|ensembl:ENST00000418205(transcript)|ensembl:ENST00000424897(transcript)|ensembl:ENST00000439781(transcript)|ensembl:ENST00000440894(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043531"(ADP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR013306(ABC transporter, B3)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03518|rcsb pdb:1JJ7|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170|dip:DIP-35626N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fkl1VU1VSl8sEjURg8kRj0joZlY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y490	intact:EBI-1257113	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14735	intact:EBI-1257113	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15404	intact:EBI-1257113	intact:EBI-1057132|uniprotkb:Q6FI17|uniprotkb:D3DRU3|uniprotkb:A8KA46|ensembl:ENSP00000339521|ensembl:ENSP00000367154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rsu1_human(display_long)|uniprotkb:RSU1(gene name)|psi-mi:RSU1(display_short)|uniprotkb:RSP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689937.2|refseq:NP_036557.1|ensembl:ENSG00000148484(gene)|ensembl:ENST00000345264(transcript)|ensembl:ENST00000377921(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT8|rcsb pdb:7LT9|reactome:R-HSA-446388	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QZduUWmFxzAxRHmcdDbCQlm6tBQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96M96	intact:EBI-1257113	intact:EBI-4401039|uniprotkb:Q6ULS2|uniprotkb:Q8TCP6|ensembl:ENSP00000394487|ensembl:ENSP00000433666|ensembl:ENSP00000462623	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fgd4_human(display_long)|uniprotkb:FGD4(gene name)|psi-mi:FGD4(display_short)|uniprotkb:FRABP(gene name synonym)|uniprotkb:ZFYVE6(gene name synonym)|uniprotkb:Actin filament-binding protein frabin(gene name synonym)|uniprotkb:FGD1-related F-actin-binding protein(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_640334.2|refseq:NP_001291409.1|refseq:XP_011518857.1|refseq:XP_011518858.1|refseq:NP_001317303.1|refseq:NP_001317302.1|ensembl:ENSG00000139132(gene)|ensembl:ENST00000427716(transcript)|ensembl:ENST00000525053(transcript)|ensembl:ENST00000583694(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035899|interpro:IPR035941|interpro:IPR037742|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-9013148|interpro:IPR017455(Zinc finger, FYVE-related)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:K4gzeBUhltm9N1SSPFdtgrmYsu89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00291	intact:EBI-1257113	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13425	intact:EBI-1257113	intact:EBI-80411|ensembl:ENSP00000338191|uniprotkb:Q9BY09	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sntb2_human(display_long)|uniprotkb:SNT2B2(gene name synonym)|uniprotkb:SNTB2(gene name)|psi-mi:SNTB2(display_short)|uniprotkb:D16S2531E(gene name synonym)|uniprotkb:SNTL(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 2(gene name synonym)|uniprotkb:Syntrophin-3(gene name synonym)|uniprotkb:Syntrophin-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR028550|interpro:IPR036034|interpro:IPR041428|mint:Q13425|rcsb pdb:2VRF|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|ensembl:ENSG00000168807(gene)|ensembl:ENST00000336278(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_006741.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SABgmvArdLH93OpFobs/L3BleVY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P29350	intact:EBI-1257113	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12981	intact:EBI-1257113	intact:EBI-4402847|uniprotkb:D3DQM3|uniprotkb:D3DQM4|uniprotkb:D3DQM5|uniprotkb:D3DQM6|uniprotkb:O75622|uniprotkb:O75623|uniprotkb:O75624|uniprotkb:Q6K044|uniprotkb:Q96FG4|ensembl:ENSP00000239215	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sec20_human(display_long)|uniprotkb:BNIP1(gene name)|psi-mi:BNIP1(display_short)|uniprotkb:NIP1(gene name synonym)|uniprotkb:SEC20L(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 1(gene name synonym)|uniprotkb:Transformation-related gene 8 protein(gene name synonym)|uniprotkb:TRG8(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001196.2|refseq:NP_053581.2|refseq:NP_053582.2|refseq:NP_053583.2|ensembl:ENSG00000113734(gene)|ensembl:ENST00000351486(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0014823"(response to activity)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR005606(Sec20)|reactome:R-HSA-6811434	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Uvkq5jKqo/7O+U7AZkeHn3JAxvc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NP97	intact:EBI-1257113	intact:EBI-372128|uniprotkb:Q5TC72|uniprotkb:Q96IV3|uniprotkb:Q9NQM2|uniprotkb:B1AKR5|ensembl:ENSP00000349679	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dlrb1_human(display_long)|uniprotkb:DYNLRB1(gene name)|psi-mi:DYNLRB1(display_short)|uniprotkb:BITH(gene name synonym)|uniprotkb:DNLC2A(gene name synonym)|uniprotkb:HSPC162(orf name)|uniprotkb:Dynein light chain 2A, cytoplasmic(gene name synonym)|uniprotkb:Dynein-associated protein Km23(gene name synonym)|uniprotkb:Bithoraxoid-like protein(gene name synonym)|uniprotkb:DNCL2A(gene name synonym)|uniprotkb:ROBLD1(gene name synonym)|uniprotkb:Roadblock domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054902.1|refseq:NP_001268656.1|refseq:NP_001268657.1|refseq:NP_001268658.1|refseq:NP_808852.1|rcsb pdb:2HZ5|rcsb pdb:6F1T|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|rcsb pdb:6RLB|rcsb pdb:6SC2|reactome:R-HSA-5620924|rcsb pdb:2E8J|ensembl:ENSG00000125971(gene)|ensembl:ENST00000357156(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0097542"(ciliary tip)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR016561(Dynein light chain, roadblock-type)|rcsb pdb:1Z09|rcsb pdb:2B95	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jUoW69LtAjTLlqS8J8KH7nImOSQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HCM4	intact:EBI-1257113	intact:EBI-1047162|uniprotkb:Q8IZ12|uniprotkb:Q9H975|uniprotkb:Q7Z5S1|ensembl:ENSP00000263713	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:e41l5_human(display_long)|uniprotkb:KIAA1548(gene name synonym)|uniprotkb:EPB41L5(gene name)|psi-mi:EPB41L5(display_short)|uniprotkb:Erythrocyte membrane protein band 4.1-like 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171866.1|refseq:NP_001171867.1|refseq:NP_001171868.1|refseq:NP_065960.2|refseq:NP_001317239.1|ensembl:ENSG00000115109(gene)|ensembl:ENST00000263713(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001839"(neural plate morphogenesis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003383"(apical constriction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006931"(substrate-dependent cell migration, cell attachment to substrate)|go:"GO:0007398"(ectoderm development)|go:"GO:0007492"(endoderm development)|go:"GO:0007509"(mesoderm migration involved in gastrulation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009826"(unidimensional cell growth)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032587"(ruffle membrane)|go:"GO:0048319"(axial mesoderm morphogenesis)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030694|interpro:IPR035963|reactome:R-HSA-6794361	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CJuB1zHpmsK3te4K5lBNrL5tyxc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5X2	intact:EBI-1257113	intact:EBI-1752557|uniprotkb:Q96I67|uniprotkb:A4D207|ensembl:ENSP00000222990	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx8_human(display_long)|uniprotkb:SNX8(gene name)|psi-mi:SNX8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037453.1|ensembl:ENSG00000106266(gene)|ensembl:ENST00000222990(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001683(Phox-like)|interpro:IPR027267|interpro:IPR028662|interpro:IPR035704|interpro:IPR036871	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:zKG84z9qGyZKxmkQV7X1IqS2cBI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92562	intact:EBI-1257113	intact:EBI-4290773|uniprotkb:Q53H49|uniprotkb:Q5TCS6|ensembl:ENSP00000230124	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fig4_human(display_long)|uniprotkb:FIG4(gene name)|psi-mi:FIG4(display_short)|uniprotkb:KIAA0274(gene name synonym)|uniprotkb:SAC3(gene name synonym)|uniprotkb:Phosphatidylinositol 3,5-bisphosphate 5-phosphatase(gene name synonym)|uniprotkb:SAC domain-containing protein 3(gene name synonym)|uniprotkb:Serine-protein phosphatase FIG4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055660.1|ensembl:ENSG00000112367(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007033"(vacuole organization)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|ensembl:ENST00000230124(transcript)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0055037"(recycling endosome)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR043573|mint:Q92562|rcsb pdb:7K1W|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3AFD3Wa7Ami26YdXc9fYhifiQfk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P17900	intact:EBI-1257113	intact:EBI-3046641|ensembl:ENSP00000349687|uniprotkb:Q14426|uniprotkb:Q14428|uniprotkb:D3DQH6|uniprotkb:B2R699|uniprotkb:Q6LBL5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sap3_human(display_long)|uniprotkb:GM2A(gene name)|psi-mi:GM2A(display_short)|uniprotkb:Cerebroside sulfate activator protein(gene name synonym)|uniprotkb:GM2-AP(gene name synonym)|uniprotkb:Sphingolipid activator protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196743(gene)|ensembl:ENST00000357164(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0007611"(learning or memory)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030290"(sphingolipid activator protein activity)|go:"GO:0032428"(beta-N-acetylgalactosaminidase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003172(MD-2-related lipid-recognition)|interpro:IPR028996|interpro:IPR036846|rcsb pdb:1G13|rcsb pdb:1PU5|rcsb pdb:1PUB|rcsb pdb:2AF9|rcsb pdb:2AG2|rcsb pdb:2AG4|rcsb pdb:2AG9|reactome:R-HSA-1660662|reactome:R-HSA-6798695|rcsb pdb:1TJJ|refseq:NP_000396.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XN1EL9XjhFB+ma/Jc1mYshhMMvY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q658P3	intact:EBI-1257113	intact:EBI-3933105|uniprotkb:Q86SF6|uniprotkb:Q9NVB5|uniprotkb:A8K6E3|uniprotkb:Q8TF03|uniprotkb:Q8TDP3|uniprotkb:Q4VBR2|uniprotkb:Q8NEW6|uniprotkb:Q53SQ8|uniprotkb:Q7Z389|uniprotkb:Q4ZG36|ensembl:ENSP00000376818|ensembl:ENSP00000376819	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stea3_human(display_long)|uniprotkb:STEAP3(gene name)|psi-mi:STEAP3(display_short)|uniprotkb:TSAP6(gene name synonym)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:pHyde(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011509705.1|refseq:NP_619543.2|ensembl:ENSG00000115107(gene)|ensembl:ENST00000393106(transcript)|ensembl:ENST00000393107(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016723"(oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor)|go:"GO:0033572"(transferrin transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|interpro:IPR036291|rcsb pdb:2VNS|rcsb pdb:2VQ3|reactome:R-HSA-6803204|reactome:R-HSA-9013148|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-917977|go:"GO:0006915"(apoptotic process)|refseq:NP_001008410.1|refseq:NP_060704.2|refseq:NP_878919.2|refseq:XP_006712677.1|refseq:XP_006712678.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fZmXHidOHx0fIw1WYbsyliQcZVA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75146	intact:EBI-1257113	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q16186	intact:EBI-1257113	intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UP83	intact:EBI-1257113	intact:EBI-389502|uniprotkb:A4D0R6|uniprotkb:A4D0R7|uniprotkb:Q6NUL5|uniprotkb:O14555|uniprotkb:O95008|ensembl:ENSP00000297135|ensembl:ENSP00000334703|ensembl:ENSP00000377228	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cog5_human(display_long)|uniprotkb:COG5(gene name)|psi-mi:COG5(display_short)|uniprotkb:GOLTC1(gene name synonym)|uniprotkb:GTC90(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 5(gene name synonym)|uniprotkb:13S Golgi transport complex 90 kDa subunit(gene name synonym)|uniprotkb:Golgi transport complex 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001154992.1|refseq:NP_006339.3|refseq:NP_859422.2|ensembl:ENSG00000164597(gene)|ensembl:ENST00000297135(transcript)|ensembl:ENST00000347053(transcript)|ensembl:ENST00000393603(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048219"(inter-Golgi cisterna vesicle-mediated transport)|interpro:IPR019465|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Jytff1Ttr5vNSps1MeFz2ZoP1Kg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P13861	intact:EBI-1257113	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NWS8	intact:EBI-1257113	intact:EBI-4401316|uniprotkb:A8K8H4|uniprotkb:Q0VDG6|uniprotkb:Q5SZ48|uniprotkb:Q5SZ83|uniprotkb:Q6NSC5|uniprotkb:Q96EN7|ensembl:ENSP00000412708|ensembl:ENSP00000507984	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rmnd1_human(display_long)|uniprotkb:RMND1(gene name)|psi-mi:RMND1(display_short)|uniprotkb:C6orf96(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060379.2|refseq:XP_005267097.1|refseq:NP_001258866.1|refseq:XP_016866477.1|ensembl:ENSG00000155906(gene)|ensembl:ENST00000444024(transcript)|ensembl:ENST00000683724(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006412"(translation)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR003734(Protein of unknown function DUF155)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yCKKEY1X6dSYbAiTBhOwnPkkxyk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12979	intact:EBI-1257113	intact:EBI-489922|uniprotkb:Q13693|uniprotkb:Q13694|uniprotkb:D3DTH4|uniprotkb:D3DTH3|uniprotkb:B3KW89|uniprotkb:F5H8B3|uniprotkb:B7Z6H7|uniprotkb:F5H3S2|ensembl:ENSP00000303909|ensembl:ENSP00000481740	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:abr_human(display_long)|uniprotkb:ABR(gene name)|psi-mi:ABR(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001153218.1|refseq:NP_001083.2|refseq:NP_068781.2|refseq:NP_001243776.1|refseq:NP_001269078.1|refseq:NP_001309769.1|ensembl:ENSG00000159842(gene)|ensembl:ENSG00000278741(gene)|ensembl:ENST00000302538(transcript)|ensembl:ENST00000612118(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR035892|interpro:IPR035899|interpro:IPR037769|interpro:IPR037865|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:BE2zC9wZOEogjE9LQ3S3D5lIqGs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IYI6	intact:EBI-1257113	intact:EBI-742102|ensembl:ENSP00000355605|uniprotkb:Q5TE82|uniprotkb:B3KU33	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc8_human(display_long)|uniprotkb:Exocyst complex 84 kDa subunit(gene name synonym)|uniprotkb:EXOC8(gene name)|psi-mi:EXOC8(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000116903(gene)|go:"GO:0031252"(cell leading edge)|ensembl:ENST00000366645(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005770"(late endosome)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_787072.2|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR032403|interpro:IPR033961|interpro:IPR042560|interpro:IPR042561|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:VXQFBw3zltr9eQ/3EgdLszUZbbs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P63000	intact:EBI-1257113	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00186	intact:EBI-1257113	intact:EBI-2803005|uniprotkb:Q86YJ3|uniprotkb:A8K5K7|uniprotkb:Q9UPD7|uniprotkb:A8K269|intact:EBI-3255674|uniprotkb:Q53FW1|ensembl:ENSP00000359025	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stxb3_human(display_long)|uniprotkb:Platelet Sec1 protein(gene name synonym)|uniprotkb:Protein unc-18 homolog 3(gene name synonym)|uniprotkb:Protein unc-18 homolog C(gene name synonym)|uniprotkb:STXBP3(gene name)|psi-mi:STXBP3(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009200.2|ensembl:ENSG00000116266(gene)|ensembl:ENST00000370008(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032868"(response to insulin)|go:"GO:0042581"(specific granule)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070820"(tertiary granule)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|reactome:R-HSA-114516|reactome:R-HSA-1445148	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iDBy0rQnIRdaV5yej86+OU1xcqk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15833	intact:EBI-1257113	intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P46060	intact:EBI-1257113	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q86Y82	intact:EBI-1257113	intact:EBI-2691717|uniprotkb:B1AJQ7|uniprotkb:O95564|ensembl:ENSP00000363054	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx12_human(display_long)|uniprotkb:STX12(gene name)|psi-mi:STX12(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_803173.1|ensembl:ENSG00000117758(gene)|ensembl:ENST00000373943(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:Q86Y82|rcsb pdb:2DNX|dip:DIP-44225N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kSTOaE08HK8SpI19dBZRZbOVCGw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14964	intact:EBI-1257113	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50395	intact:EBI-1257113	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P23458	intact:EBI-1257113	intact:EBI-1383438|uniprotkb:Q59GQ2|uniprotkb:Q9UD26|ensembl:ENSP00000343204|ensembl:ENSP00000499884|ensembl:ENSP00000499900|ensembl:ENSP00000500296|ensembl:ENSP00000500485|ensembl:ENSP00000500841	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:jak1_human(display_long)|uniprotkb:JAK1(gene name)|psi-mi:JAK1(display_short)|uniprotkb:JAK1A(gene name synonym)|uniprotkb:JAK1B(gene name synonym)|uniprotkb:Janus kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001308785.1|refseq:NP_002218.2|refseq:NP_001307852.1|refseq:NP_001308781.1|refseq:NP_001308782.1|refseq:NP_001308783.1|refseq:NP_001308784.1|dip:DIP-133N|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-909733|ensembl:ENSG00000162434(gene)|ensembl:ENST00000342505(transcript)|ensembl:ENST00000671929(transcript)|ensembl:ENST00000671954(transcript)|ensembl:ENST00000672179(transcript)|ensembl:ENST00000672247(transcript)|ensembl:ENST00000672434(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P23458|rcsb pdb:3EYG|rcsb pdb:3EYH|rcsb pdb:4E4L|rcsb pdb:4E4N|rcsb pdb:4E5W|rcsb pdb:4EHZ|rcsb pdb:4EI4|rcsb pdb:4FK6|rcsb pdb:4GS0|rcsb pdb:4I5C|rcsb pdb:4IVB|rcsb pdb:4IVC|rcsb pdb:4IVD|rcsb pdb:4K6Z|rcsb pdb:4K77|rcsb pdb:4L00|rcsb pdb:4L01|rcsb pdb:5E1E|rcsb pdb:5HX8|rcsb pdb:5IXD|rcsb pdb:5IXI|rcsb pdb:5KHW|rcsb pdb:5KHX|rcsb pdb:5L04|rcsb pdb:5WO4|rcsb pdb:6AAH|rcsb pdb:6BBU|rcsb pdb:6C7Y|rcsb pdb:6DBN|rcsb pdb:6ELR|rcsb pdb:6GGH|rcsb pdb:6HZU|rcsb pdb:6N77|rcsb pdb:6N78|rcsb pdb:6N79|rcsb pdb:6N7A|rcsb pdb:6N7B|rcsb pdb:6N7C|rcsb pdb:6N7D|rcsb pdb:6RSB|rcsb pdb:6RSC|rcsb pdb:6RSD|rcsb pdb:6RSE|rcsb pdb:6RSH|rcsb pdb:6SM8|rcsb pdb:6SMB|rcsb pdb:6TPE|rcsb pdb:6TPF|rcsb pdb:6W8L|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1169408|reactome:R-HSA-1266695|reactome:R-HSA-449836|reactome:R-HSA-5673001|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020591|reactome:R-HSA-9020956|reactome:R-HSA-9020958	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:gEEiBAxwXnGGFWwO7OC0l0KjmSY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O75436	intact:EBI-1257113	intact:EBI-1043891|uniprotkb:Q8TBH4|uniprotkb:Q9H982|ensembl:ENSP00000263559|ensembl:ENSP00000362480|uniprotkb:B2RDD3|uniprotkb:A8MZ56	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp26a_human(display_long)|uniprotkb:VPS26A(gene name)|psi-mi:VPS26A(display_short)|uniprotkb:VPS26(gene name synonym)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000122958(gene)|ensembl:ENST00000263559(transcript)|ensembl:ENST00000373382(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:O75436|rcsb pdb:2FAU|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|reactome:R-HSA-3238698|rcsb pdb:7BLO|refseq:NP_001030337.1|refseq:NP_004887.2|refseq:NP_001305875.1|dip:DIP-29075N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:n0uOd+2HQmRW7koIy678uP0d3+o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15836	intact:EBI-1257113	intact:EBI-722343|uniprotkb:Q9BRV4|ensembl:ENSP00000054666	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vamp3_human(display_long)|uniprotkb:Synaptobrevin-3(gene name synonym)|uniprotkb:Cellubrevin(gene name synonym)|uniprotkb:VAMP3(gene name)|psi-mi:VAMP3(display_short)|uniprotkb:SYB3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004772.1|dip:DIP-56422N|ensembl:ENSG00000049245(gene)|ensembl:ENST00000054666(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903531"(negative regulation of secretion by cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q15836|reactome:R-HSA-1236974|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JeCaIwh36OpRqMG0MFnpFZyN6jU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P07948	intact:EBI-1257113	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95295	intact:EBI-1257113	intact:EBI-296723|ensembl:ENSP00000357674|uniprotkb:Q5SXU8|uniprotkb:D3DV56	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snapn_human(display_long)|uniprotkb:SNAPIN(gene name)|psi-mi:SNAPIN(display_short)|uniprotkb:SNAP25BP(gene name synonym)|uniprotkb:SNAPAP(gene name synonym)|uniprotkb:Synaptosomal-associated protein 25-binding protein(gene name synonym)|uniprotkb:BLOC1S7(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143553(gene)|ensembl:ENST00000368685(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030141"(secretory granule)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032438"(melanosome organization)|go:"GO:0034629"|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051604"(protein maturation)|go:"GO:0072553"(terminal button organization)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0099078"(BORC complex)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR017246(Snapin)|interpro:IPR028119|reactome:R-HSA-432722|refseq:NP_036569.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:V43p5MNgzla9VrcFKxPEIGWxYCM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P60953-2	intact:EBI-1257113	intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P53990-2	intact:EBI-1257113	intact:EBI-4402971|ensembl:ENSP00000368075	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p53990-2(display_long)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:KIAA0174(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-945994(isoform-parent)|uniprotkb:P53990-2(isoform-parent)|ensembl:ENSG00000182149(gene)|ensembl:ENST00000378798(transcript)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:LJQ3n1ear+vuRho2idZCPkB0HFo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HCE6	intact:EBI-1257113	intact:EBI-724864|uniprotkb:Q6P0L7|uniprotkb:Q8NAV5|uniprotkb:Q9NVT3|uniprotkb:Q17RW1|uniprotkb:Q3YFJ4|uniprotkb:Q5VXI5|uniprotkb:Q5VXI6|uniprotkb:Q66K51|uniprotkb:B7ZKS1|ensembl:ENSP00000355060	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:argal_human(display_long)|uniprotkb:GRINCHGEF(gene name synonym)|uniprotkb:KIAA1626(gene name synonym)|uniprotkb:GrinchGEF(gene name synonym)|uniprotkb:ARHGEF10L(gene name)|psi-mi:ARHGEF10L(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001306766.1|refseq:NP_001306767.1|refseq:NP_001011722.2|refseq:NP_060595.3|ensembl:ENSG00000074964(gene)|ensembl:ENST00000361221(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035899|interpro:IPR036322|interpro:IPR039919|refseq:NP_001315053.1|refseq:XP_005245982.2|refseq:XP_016857106.1|refseq:XP_016857110.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:HWnqkCHhpqMiOEwoYw8Uhfn8N+w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P0V9	intact:EBI-1257113	intact:EBI-3943788|uniprotkb:B3KRQ9|uniprotkb:Q86VP5|uniprotkb:Q9HAH6|ensembl:ENSP00000380824	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sep10_human(display_long)|uniprotkb:SEPTIN10(gene name)|psi-mi:SEPTIN10(display_short)|uniprotkb:SEPT10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_653311.1|refseq:NP_848699.1|refseq:NP_001308433.1|refseq:NP_001308425.1|refseq:NP_001308427.1|refseq:NP_001308434.1|refseq:NP_001308435.1|refseq:NP_001308428.1|refseq:NP_001308436.1|refseq:NP_001308429.1|refseq:NP_001308437.1|refseq:NP_001308438.1|refseq:NP_001308439.1|refseq:NP_001308430.1|refseq:NP_001308431.1|refseq:NP_001308432.1|refseq:NP_001308440.1|refseq:NP_001308441.1|go:"GO:0034613"(cellular protein localization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|ensembl:ENSG00000186522(gene)|ensembl:ENST00000397712(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:z/yRE0i+Q5BlAYMdl77BWUhFsQw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NEN9	intact:EBI-1257113	intact:EBI-4289868|uniprotkb:Q86WE5|uniprotkb:Q9UFF1|uniprotkb:Q86WE0|ensembl:ENSP00000334642	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pdzd8_human(display_long)|uniprotkb:PDZD8(gene name)|psi-mi:PDZD8(display_short)|uniprotkb:PDZK8(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-84/NY-SAR-104(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165650(gene)|ensembl:ENST00000334464(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR031468|interpro:IPR036034|interpro:IPR039275|interpro:IPR041489|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|refseq:NP_776152.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:J/uE/PwFeE+ZL58Qi2jAWaEf23s9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H4L5	intact:EBI-1257113	intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TC07	intact:EBI-1257113	intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H267	intact:EBI-1257113	intact:EBI-749072|uniprotkb:Q96K14|uniprotkb:Q9NRP6|uniprotkb:Q9NSF3|uniprotkb:B3KQF6|ensembl:ENSP00000327650	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vp33b_human(display_long)|uniprotkb:VPS33B(gene name)|psi-mi:VPS33B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061138.3|refseq:NP_001276077.1|refseq:XP_011519750.1|refseq:NP_001276078.1|refseq:XP_005254944.1|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|interpro:IPR043155|mint:Q9H267|reactome:R-HSA-9636383|interpro:IPR027121|ensembl:ENSG00000184056(gene)|ensembl:ENST00000333371(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007032"(endosome organization)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030897"(HOPS complex)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032418"(lysosome localization)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0033263"(CORVET complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0070889"(platelet alpha granule organization)|interpro:IPR001619(Sec1-like protein)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:T2rUOt9qjfn8vCzySAKCCa3UC689606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P01111	intact:EBI-1257113	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61966	intact:EBI-1257113	intact:EBI-516199|uniprotkb:P82267|uniprotkb:Q00382|uniprotkb:Q9BTN4|uniprotkb:Q9UDW9|uniprotkb:Q53YA7|uniprotkb:B2R5D8|ensembl:ENSP00000336666|ensembl:ENSP00000410780	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap1s1_human(display_long)|uniprotkb:Sigma-adaptin 1A(gene name synonym)|uniprotkb:Sigma1A-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1A subunit(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1A small chain(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Sigma 1a subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1A(gene name synonym)|uniprotkb:AP1S1(gene name)|psi-mi:AP1S1(display_short)|uniprotkb:AP19(gene name synonym)|uniprotkb:CLAPS1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001274.1|ensembl:ENSG00000106367(gene)|ensembl:ENST00000337619(transcript)|ensembl:ENST00000443943(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|mint:P61966|rcsb pdb:4P6Z|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:2lE9ZcVbrYANDaYhT4mLYzppefA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NV70	intact:EBI-1257113	intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P36507	intact:EBI-1257113	intact:EBI-1056930|ensembl:ENSP00000262948|intact:EBI-15586042	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mp2k2_human(display_long)|uniprotkb:MAP2K2(gene name)|psi-mi:MAP2K2(display_short)|uniprotkb:MEK2(gene name synonym)|uniprotkb:MKK2(gene name synonym)|uniprotkb:PRKMK2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_109587.1|ensembl:ENSG00000126934(gene)|ensembl:ENST00000262948(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36507|rcsb pdb:1S9I|rcsb pdb:4H3Q|reactome:R-HSA-112411|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|go:"GO:0005634"(nucleus)|dip:DIP-29119N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:JnGMm7dA0eZgBV4A/n+ZjE8ATq49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27797	intact:EBI-1257113	intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H269	intact:EBI-1257113	intact:EBI-2655929|uniprotkb:Q5JUB1|uniprotkb:Q8WU31|uniprotkb:Q96EE7|uniprotkb:Q96N92|uniprotkb:Q9H1Q4|uniprotkb:Q9H1Q5|ensembl:ENSP00000369810	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps16_human(display_long)|uniprotkb:VPS16(gene name)|psi-mi:VPS16(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_072097.2|refseq:NP_536338.1|ensembl:ENSG00000215305(gene)|ensembl:ENST00000380445(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR038132|mint:Q9H269|rcsb pdb:4BX9	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bm088LmFRv3w0wfvlPMFeottZkw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P10398	intact:EBI-1257113	intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P85298	intact:EBI-1257113	intact:EBI-4289876|uniprotkb:Q9NVX8|uniprotkb:Q9HC46|uniprotkb:Q9HA49|uniprotkb:O75983|uniprotkb:Q96RW2|uniprotkb:Q9NXL1|uniprotkb:O95695|uniprotkb:Q9UH20|uniprotkb:Q9NSG0|uniprotkb:Q96RW1|uniprotkb:A6ZJ80|ensembl:ENSP00000374424|uniprotkb:A6ZJ79	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg08_human(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036865|reactome:R-HSA-8980692|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|ensembl:ENSG00000241484(gene)|ensembl:ENST00000389774(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000198(RhoGAP)|refseq:NP_001017526.1|refseq:NP_001185655.1|refseq:NP_851852.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UqN4Tj7Wd/7NqV7exVGSjtYC+Qc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q15382	intact:EBI-1257113	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O00461	intact:EBI-1257113	intact:EBI-4401217|ensembl:ENSP00000417354	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:goli4_human(display_long)|uniprotkb:Golgi-localized phosphoprotein of 130 kDa(gene name synonym)|uniprotkb:GOLIM4(gene name)|psi-mi:GOLIM4(display_short)|uniprotkb:GIMPC(gene name synonym)|uniprotkb:GOLPH4(gene name synonym)|uniprotkb:GPP130(gene name synonym)|uniprotkb:Golgi integral membrane protein, cis(gene name synonym)|uniprotkb:Golgi phosphoprotein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055313.1|dip:DIP-61898N|ensembl:ENSG00000173905(gene)|ensembl:ENST00000470487(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032580"(Golgi cisterna membrane)|interpro:IPR042336|reactome:R-HSA-6811438	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IYYs/JH0wij/6jEmZwwPVc377pU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BRG2	intact:EBI-1257113	intact:EBI-2339271|uniprotkb:Q9Y2X4|uniprotkb:B4DRS7|uniprotkb:A8K9R6|intact:EBI-28982569|ensembl:ENSP00000245908	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sh23a_human(display_long)|uniprotkb:SH2D3A(gene name)|psi-mi:SH2D3A(display_short)|uniprotkb:NSP1(gene name synonym)|uniprotkb:Novel SH2-containing protein 1(gene name synonym)|uniprotkb:UNQ175/PRO201(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005481.2|refseq:XP_005259529.1|ensembl:ENSP00000245908|ensembl:ENST00000437152|ensembl:ENSP00000393303|ensembl:ENSG00000125731(gene)|ensembl:ENST00000245908(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|interpro:IPR000980(SH2 motif)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR023578|interpro:IPR036860|interpro:IPR036964|interpro:IPR044102|mint:Q9BRG2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8PTqqhIlumS0fnzVS9vJAZPByQQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UK41	intact:EBI-1257113	intact:EBI-727424|uniprotkb:Q86VK0|ensembl:ENSP00000292510|ensembl:ENSP00000434064|ensembl:ENSP00000496519|ensembl:ENSP00000496693	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps28_human(display_long)|uniprotkb:VPS28(gene name)|psi-mi:VPS28(display_short)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057292.1|refseq:NP_898880.1|ensembl:ENSG00000160948(gene)|ensembl:ENSG00000285339(gene)|ensembl:ENST00000292510(transcript)|ensembl:ENST00000526054(transcript)|ensembl:ENST00000642867(transcript)|ensembl:ENST00000643186(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|mint:Q9UK41|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:GUcc7bRf1LaLklAYVLEHRSihPjA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9P2R3	intact:EBI-1257113	intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:237ungtRc80jqTOKBUnFX9qDUGw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61225	intact:EBI-1257113	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q07866	intact:EBI-1257113	intact:EBI-721019|uniprotkb:F8VTM4|uniprotkb:Q7RTQ3|uniprotkb:Q86V77|uniprotkb:Q86V78|uniprotkb:Q86V79|uniprotkb:Q7RTM2|uniprotkb:Q7RTM3|uniprotkb:Q7RTM5|uniprotkb:Q7RTP9|uniprotkb:Q7RTQ5|uniprotkb:Q7RTQ6|uniprotkb:Q86SF5|uniprotkb:Q86TF5|uniprotkb:Q86V74|uniprotkb:Q86V75|uniprotkb:Q86V76|uniprotkb:Q96H62|uniprotkb:A6NF62|intact:EBI-28976313|ensembl:ENSP00000341154	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:klc1_human(display_long)|uniprotkb:KLC1(gene name)|psi-mi:KLC1(display_short)|uniprotkb:KLC(gene name synonym)|uniprotkb:KNS2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001123579.1|refseq:NP_005543.2|refseq:NP_891553.2|ensembl:ENST00000452929|ensembl:ENSP00000414982|ensembl:ENST00000553286|ensembl:ENSP00000452487|ensembl:ENST00000246489|ensembl:ENSP00000246489|ensembl:ENST00000334553|ensembl:ENST00000554228|ensembl:ENSP00000450616|ensembl:ENST00000557450|ensembl:ENSP00000450648|ensembl:ENST00000634686|ensembl:ENSP00000488938|ensembl:ENSP00000334523|ensembl:ENST00000347839|ensembl:ENSP00000334618|ensembl:ENSP00000341154|ensembl:ENST00000389744|ensembl:ENSP00000374394|dip:DIP-40371N|ensembl:ENSG00000126214(gene)|ensembl:ENST00000348520(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035617"(stress granule disassembly)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q07866|rcsb pdb:3NF1|rcsb pdb:5OJ8|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|go:"GO:0030426"(growth cone)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:T7SJbB/PScRqj74O/NH4q1KU0YM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92783	intact:EBI-1257113	intact:EBI-752333|uniprotkb:Q8N6D9|uniprotkb:B0YJ99|intact:EBI-3447129|uniprotkb:D3DRU5|intact:EBI-28983444|ensembl:ENSP00000366746	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stam1_human(display_long)|uniprotkb:STAM(gene name)|psi-mi:STAM(display_short)|uniprotkb:STAM1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003464.1|ensembl:ENSP00000366746|dip:DIP-37761N|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035657|interpro:IPR036028|mint:Q92783|rcsb pdb:2L0A|rcsb pdb:3F1I|rcsb pdb:3LDZ|reactome:R-HSA-182971|reactome:R-HSA-5689901|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|ensembl:ENSG00000136738(gene)|ensembl:ENST00000377524(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016236"(macroautophagy)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+XzmsTsMqOFTM5SM1fuVB+0UzeQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13409	intact:EBI-1257113	intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13190	intact:EBI-1257113	intact:EBI-714206|uniprotkb:Q5U0D4|uniprotkb:Q7Z3T6|uniprotkb:Q9BUG1|uniprotkb:B2R8T2|ensembl:ENSP00000294179|uniprotkb:F8W8Q9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx5_human(display_long)|uniprotkb:STX5(gene name)|psi-mi:STX5(display_short)|uniprotkb:STX5A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003155.2|ensembl:ENSG00000162236(gene)|ensembl:ENST00000294179(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031982"(vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0090166"(Golgi disassembly)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR021538|mint:Q13190|rcsb pdb:3EFO|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-8980692|reactome:R-HSA-9013106|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-9013408|reactome:R-HSA-9609523|refseq:NP_001231595.1|refseq:NP_001317223.1|dip:DIP-56987N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:cR4cS695ZWQQ5Bkim9HqmCE0hCE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P36404	intact:EBI-1257113	intact:EBI-752365|uniprotkb:Q9BUK8|uniprotkb:G3V184|ensembl:ENSP00000246747|ensembl:ENSP00000436021	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl2_human(display_long)|uniprotkb:ARL2(gene name)|psi-mi:ARL2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001186674.1|refseq:NP_001658.2|dip:DIP-47535N|ensembl:ENSG00000213465(gene)|ensembl:ENST00000246747(transcript)|ensembl:ENST00000529384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:P36404|rcsb pdb:3DOE|rcsb pdb:3DOF|reactome:R-HSA-389977|reactome:R-HSA-83936|reactome:R-HSA-9648002	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ArQxx65a8vITU2O0Kr0Qo0hqiqU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H7D0	intact:EBI-1257113	intact:EBI-1773858|uniprotkb:Q5XKD5|uniprotkb:Q6AI11|uniprotkb:Q6PJS6|uniprotkb:Q6ZTS6|uniprotkb:B2RNY0|ensembl:ENSP00000276440|intact:EBI-28975706	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dock5_human(display_long)|uniprotkb:DOCK5(gene name)|psi-mi:DOCK5(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000276440|ensembl:ENST00000481100|ensembl:ENSP00000429737|refseq:NP_079216.4|ensembl:ENSG00000147459(gene)|ensembl:ENST00000276440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904694"(negative regulation of vascular associated smooth muscle contraction)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR030717|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q9H7D0|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-983231|go:"GO:0007264"(small GTPase mediated signal transduction)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/+sUfMB7hLZjdyhsMQ8WKJoXXLU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15126	intact:EBI-1257113	intact:EBI-954338|ensembl:ENSP00000481022|uniprotkb:O43587|uniprotkb:Q96BX1|uniprotkb:Q96QK5|uniprotkb:Q6FG23	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scam1_human(display_long)|uniprotkb:SCAMP1(gene name)|psi-mi:SCAMP1(display_short)|uniprotkb:SCAMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000085365(gene)|ensembl:ENST00000621999(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|reactome:R-HSA-6798695|refseq:NP_004857.4|refseq:NP_001277158.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Utuf4fnpMHS2yG4zfccdB2enfxI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P84095	intact:EBI-1257113	intact:EBI-446579|uniprotkb:P35238|uniprotkb:Q8NI04|ensembl:ENSP00000339467|ensembl:ENSP00000380175|ensembl:ENSP00000380176|ensembl:ENSP00000436932	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhog_human(display_long)|uniprotkb:RHOG(gene name)|psi-mi:RHOG(display_short)|uniprotkb:ARHG(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001656.2|refseq:XP_005252973.1|refseq:XP_016873208.1|ensembl:ENST00000396978(transcript)|ensembl:ENST00000396979(transcript)|ensembl:ENST00000533217(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|ensembl:ENSG00000177105(gene)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|ensembl:ENST00000351018(transcript)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042734|mint:P84095|rcsb pdb:6UKA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5625970|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-9013408	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9PItVl1k5j6JhIDqwqcov1E/N8w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q66K14	intact:EBI-1257113	intact:EBI-2688824|uniprotkb:O75163|uniprotkb:D3DWQ6|uniprotkb:Q96H49|uniprotkb:Q6MZI2|uniprotkb:Q53EY0|uniprotkb:D3DWQ5|ensembl:ENSP00000349291|ensembl:ENSP00000491373|ensembl:ENSP00000491970	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tbc9b_human(display_long)|uniprotkb:KIAA0676(gene name synonym)|uniprotkb:TBC1D9B(gene name)|psi-mi:TBC1D9B(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055858.2|refseq:NP_942568.2|ensembl:ENSG00000197226(gene)|ensembl:ENSG00000284400(gene)|ensembl:ENST00000356834(transcript)|ensembl:ENST00000639361(transcript)|ensembl:ENST00000639711(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036014|interpro:IPR036017|mint:Q66K14	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DdCLCQa69pLYH6eIKdazflUwAKY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P61586	intact:EBI-1257113	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P13473	intact:EBI-1257113	intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92599	intact:EBI-1257113	intact:EBI-958021|uniprotkb:Q8IX36|uniprotkb:Q8IX37|uniprotkb:Q9BVB3|uniprotkb:A6NC65|uniprotkb:A6NKP6|ensembl:ENSP00000367991|uniprotkb:F6W7K9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sept8_human(display_long)|uniprotkb:SEPTIN8(gene name)|psi-mi:SEPTIN8(display_short)|uniprotkb:KIAA0202(gene name synonym)|uniprotkb:SEPT8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001092281.1|refseq:NP_001092282.1|refseq:NP_001092283.1|refseq:NP_055961.1|refseq:NP_001287727.1|refseq:NP_001287728.1|ensembl:ENSG00000164402(gene)|ensembl:ENST00000378719(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031105"(septin complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032153"(cell division site)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030646|rcsb pdb:6UPR|rcsb pdb:6WSM	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QuM5Q14J4dl4Efbubz2wrqcyTiQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NQZ5	intact:EBI-1257113	intact:EBI-4402938|uniprotkb:D3DXG9|uniprotkb:Q53T44|uniprotkb:Q6GU43|uniprotkb:Q969M6|ensembl:ENSP00000338030	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:star7_human(display_long)|uniprotkb:STARD7(gene name)|psi-mi:STARD7(display_short)|uniprotkb:GTT1(gene name synonym)|uniprotkb:Gestational trophoblastic tumor protein 1(gene name synonym)|uniprotkb:START domain-containing protein 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_064536.2|ensembl:ENSG00000084090(gene)|ensembl:ENST00000337288(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|interpro:IPR002913(Lipid-binding START)|interpro:IPR023393|interpro:IPR041949|reactome:R-HSA-1483191	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IumLsd1b+hqnlC9WmBLpXjGXmLs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q12768	intact:EBI-1257113	intact:EBI-2563794|uniprotkb:A8K4R7|uniprotkb:Q3KQX5|uniprotkb:Q8TBQ2|ensembl:ENSP00000318016	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wasc5_human(display_long)|uniprotkb:WASHC5(gene name)|psi-mi:WASHC5(display_short)|uniprotkb:KIAA0196(gene name synonym)|uniprotkb:Strumpellin(gene name synonym)|uniprotkb:WASH complex subunit strumpellin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055661.3|ensembl:ENSG00000164961(gene)|ensembl:ENST00000318410(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034629"|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051125"(regulation of actin nucleation)|go:"GO:0071203"(WASH complex)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0140285"(endosome fission)|interpro:IPR019393|mint:Q12768|refseq:XP_016869602.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:9QEw0Z7NIOvpVJtWXcLp67ApJdk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q14C86	intact:EBI-1257113	intact:EBI-1049788|intact:EBI-1384220|intact:EBI-2654427|uniprotkb:Q8ND92|uniprotkb:Q9P207|uniprotkb:Q9Y4N0|uniprotkb:A8MYK3|uniprotkb:Q14C76|uniprotkb:Q2Q1W1|uniprotkb:Q8WU86|uniprotkb:Q96CZ4|uniprotkb:Q9NXQ1|uniprotkb:B0QZ62|uniprotkb:B0QZ63|uniprotkb:B0QZ64|intact:EBI-2558352|ensembl:ENSP00000377664|ensembl:ENSP00000419063	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gapd1_human(display_long)|uniprotkb:GAPVD1(gene name)|psi-mi:GAPVD1(display_short)|uniprotkb:GAPEX5(gene name synonym)|uniprotkb:KIAA1521(gene name synonym)|uniprotkb:RAP6(gene name synonym)|uniprotkb:Rab5-activating protein 6(gene name synonym)|uniprotkb:GAPex-5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001269608.1|refseq:NP_001269609.1|refseq:NP_001269610.1|refseq:NP_001317707.1|refseq:XP_016870095.1|refseq:XP_016870096.1|refseq:XP_016870097.1|refseq:NP_056450.2|refseq:XP_016870098.1|refseq:XP_005251961.1|ensembl:ENSG00000165219(gene)|ensembl:ENST00000394104(transcript)|ensembl:ENST00000495955(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051223"(regulation of protein transport)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR037191|interpro:IPR041545|mint:Q14C86|reactome:R-HSA-8856828|reactome:R-HSA-8876198|refseq:XP_006717107.1|refseq:XP_005251958.1|refseq:XP_016870090.1|refseq:XP_016870091.1|refseq:XP_016870092.1|refseq:XP_016870093.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SX6gvb2Odit7L3I+Dtc5ub+qixE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15498	intact:EBI-1257113	intact:EBI-4402903|uniprotkb:Q53F01|uniprotkb:Q6FGU9|uniprotkb:Q6IB15|uniprotkb:B4DR94|ensembl:ENSP00000223369|ensembl:ENSP00000504623	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ykt6_human(display_long)|uniprotkb:YKT6(gene name)|psi-mi:YKT6(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006546.1|refseq:XP_016867171.1|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|rcsb pdb:6J74|rcsb pdb:6J7F|rcsb pdb:6J7X|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9013423|go:"GO:0030659"(cytoplasmic vesicle membrane)|ensembl:ENSG00000106636(gene)|ensembl:ENST00000223369(transcript)|ensembl:ENST00000679020(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030133"(transport vesicle)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pkTOoQ9XXEVYHKNvqOMCU6x4nZg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5K8	intact:EBI-1257113	intact:EBI-2684998|uniprotkb:Q9Y688|uniprotkb:B2RE33|ensembl:ENSP00000216442|ensembl:ENSP00000451167	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatd_human(display_long)|uniprotkb:ATP6M(gene name synonym)|uniprotkb:VATD(gene name synonym)|uniprotkb:V-ATPase 28 kDa accessory protein(gene name synonym)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)|uniprotkb:ATP6V1D(gene name)|psi-mi:ATP6V1D(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_057078.1|ensembl:ENSG00000100554(gene)|ensembl:ENST00000216442(transcript)|ensembl:ENST00000554087(transcript)|go:"GO:0005765"(lysosomal membrane)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|mint:Q9Y5K8|rcsb pdb:6WLZ|go:"GO:0005829"(cytosol)|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UBGjCKLxcq9lkUY/Vh6+Kr2i+uk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H270	intact:EBI-1257113	intact:EBI-373380|uniprotkb:Q8WY89|uniprotkb:Q96EP8|uniprotkb:Q9H6D9|uniprotkb:Q9HCS6|ensembl:ENSP00000479680	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vps11_human(display_long)|uniprotkb:VPS11(gene name)|psi-mi:VPS11(display_short)|uniprotkb:PP3476(orf name)|uniprotkb:RING finger protein 108(gene name synonym)|uniprotkb:RNF108(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068375.3|refseq:NP_001277114.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016528(Vacuolar protein sorting-associated protein 11)|interpro:IPR024763|interpro:IPR036322|mint:Q9H270|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|ensembl:ENSG00000160695(gene)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|ensembl:ENST00000620429(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005764"(lysosome)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0030897"(HOPS complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0007033"(vacuole organization)|go:"GO:0048284"(organelle fusion)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:jHCrh6Lc0dS37Fumbf/lTE8Y1Og9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NUP9	intact:EBI-1257113	intact:EBI-1171517|ensembl:ENSP00000278193	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O60645	intact:EBI-1257113	intact:EBI-1052278|uniprotkb:Q8TEN6|uniprotkb:Q8WUW0|uniprotkb:Q96DI4|uniprotkb:Q6P2E8|ensembl:ENSP00000323377|ensembl:ENSP00000425587|intact:EBI-11944037	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc3_human(display_long)|uniprotkb:Exocyst complex component Sec6(gene name synonym)|uniprotkb:EXOC3(gene name)|psi-mi:EXOC3(display_short)|uniprotkb:SEC6(gene name synonym)|uniprotkb:SEC6L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016864492.1|refseq:XP_016864493.1|ensembl:ENSG00000180104(gene)|ensembl:ENST00000315013(transcript)|ensembl:ENST00000512944(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000149"(SNARE binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051601"(exocyst localization)|interpro:IPR010326(Exocyst complex component Sec6)|interpro:IPR042532|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0030426"(growth cone)|refseq:NP_009208.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:7nhIGGYkkrej3iW0UKDqP5BwUz09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96CW1	intact:EBI-1257113	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52824	intact:EBI-1257113	intact:EBI-4401238|uniprotkb:Q6P3W4|ensembl:ENSP00000273814	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dgkq_human(display_long)|uniprotkb:DGKQ(gene name)|psi-mi:DGKQ(display_short)|uniprotkb:DAGK4(gene name synonym)|uniprotkb:Diglyceride kinase theta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001338.2|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051591"(response to cAMP)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:2000064"(regulation of cortisol biosynthetic process)|go:"GO:2000182"(regulation of progesterone biosynthetic process)|interpro:IPR000159(Ras-association)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR029071|interpro:IPR037607|reactome:R-HSA-114508|ensembl:ENSG00000145214(gene)|ensembl:ENST00000273814(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:EIx+aVfl0V0AE3dpJxWzFlaRMf89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O43237	intact:EBI-1257113	intact:EBI-715294|uniprotkb:Q8TAT3|uniprotkb:A8K6V1|uniprotkb:B4DZP4|ensembl:ENSP00000258198	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dc1l2_human(display_long)|uniprotkb:Dynein light intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:LIC53/55(gene name synonym)|uniprotkb:DYNC1LI2(gene name)|psi-mi:DYNC1LI2(display_short)|uniprotkb:LIC2(gene name synonym)|uniprotkb:DNCLI2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006132.1|refseq:NP_001273086.1|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0051642"(centrosome localization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|go:"GO:0000776"(kinetochore)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR027417|rcsb pdb:6F1T|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|ensembl:ENSG00000135720(gene)|ensembl:ENST00000258198(transcript)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WUEd3zgPhcKEe10gtoJ+okX8Zps9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HD26	intact:EBI-1257113	intact:EBI-349832|uniprotkb:A6NM30|uniprotkb:Q59FS4|uniprotkb:Q969U8|ensembl:ENSP00000357484	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gopc_human(display_long)|uniprotkb:CAL(gene name synonym)|uniprotkb:FIG(gene name synonym)|uniprotkb:GOPC(gene name)|psi-mi:GOPC(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym)|uniprotkb:CFTR-associated ligand(gene name synonym)|uniprotkb:Fused in glioblastoma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001017408.1|refseq:NP_065132.1|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045176"(apical protein localization)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR038879|mint:Q9HD26|rcsb pdb:2DC2|rcsb pdb:2LOB|rcsb pdb:4E34|rcsb pdb:4E35|rcsb pdb:4JOE|rcsb pdb:4JOF|rcsb pdb:4JOG|rcsb pdb:4JOH|rcsb pdb:4JOJ|rcsb pdb:4JOK|rcsb pdb:4JOP|rcsb pdb:4JOR|rcsb pdb:4K6Y|rcsb pdb:4K72|rcsb pdb:4K75|rcsb pdb:4K76|rcsb pdb:4K78|rcsb pdb:4NMO|rcsb pdb:4NMP|rcsb pdb:4NMQ|rcsb pdb:4NMR|rcsb pdb:4NMS|rcsb pdb:4NMT|go:"GO:0042802"(identical protein binding)|rcsb pdb:4NMV|rcsb pdb:4Q6H|rcsb pdb:4Q6S|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6OV7|rcsb pdb:6V84|rcsb pdb:6XNJ|reactome:R-HSA-5627083|reactome:R-HSA-9013406|ensembl:ENSG00000047932(gene)|ensembl:ENST00000368498(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032991"(protein-containing complex)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:bXzu5wvJifZwB+Q52cgC4tZQl/k9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6DT37	intact:EBI-1257113	intact:EBI-689124|uniprotkb:O00565|ensembl:ENSP00000345133	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mrckg_human(display_long)|uniprotkb:CDC42-binding protein kinase gamma(gene name synonym)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase gamma(gene name synonym)|uniprotkb:Myotonic dystrophy protein kinase-like alpha(gene name synonym)|uniprotkb:DMPK-like gamma(gene name synonym)|uniprotkb:CDC42BPG(gene name)|psi-mi:CDC42BPG(display_short)|uniprotkb:DMPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_059995.2|ensembl:ENSG00000171219(gene)|ensembl:ENST00000342711(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033235|mint:Q6DT37	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:/5QgvZCMEP21tioJtKmAvbJvyms9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8WWN8	intact:EBI-1257113	intact:EBI-4402732|uniprotkb:D3DQE3|uniprotkb:B4DIT1|ensembl:ENSP00000239440	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arap3_human(display_long)|uniprotkb:ARAP3(gene name)|psi-mi:ARAP3(display_short)|uniprotkb:CENTD3(gene name synonym)|uniprotkb:Centaurin-delta-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071926.4|ensembl:ENSG00000120318(gene)|ensembl:ENST00000239440(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029071|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|mint:Q8WWN8|rcsb pdb:2KG5|rcsb pdb:2LNW|rcsb pdb:5JCP|rcsb pdb:5JD0|rcsb pdb:7A9B|reactome:R-HSA-8980692	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pM4xyUzJ02vuF54OL5nXphskHkI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96HS1	intact:EBI-1257113	intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96KG9	intact:EBI-1257113	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P50552	intact:EBI-1257113	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8TAG9	intact:EBI-1257113	intact:EBI-1223394|uniprotkb:Q9NZ24|uniprotkb:Q5VXH8|uniprotkb:E9PHI3|ensembl:ENSP00000260762	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:exoc6_human(display_long)|uniprotkb:EXOC6(gene name)|psi-mi:EXOC6(display_short)|uniprotkb:SEC15A(gene name synonym)|uniprotkb:SEC15L(gene name synonym)|uniprotkb:SEC15L1(gene name synonym)|uniprotkb:Exocyst complex component Sec15A(gene name synonym)|uniprotkb:SEC15-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001013870.1|refseq:NP_061926.3|refseq:XP_016871834.1|refseq:NP_001306123.1|refseq:NP_001306124.1|refseq:NP_001306129.1|ensembl:ENSG00000138190(gene)|ensembl:ENST00000260762(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090522"(vesicle tethering involved in exocytosis)|go:"GO:0090543"(Flemming body)|interpro:IPR007225(Exocyst complex subunit Sec15-like)|interpro:IPR042044|interpro:IPR042045|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|mint:Q8TAG9	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:M+NozbnYI3iV+onpii45135rGio9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96BR1	intact:EBI-1257113	intact:EBI-2801236|uniprotkb:A8K5W3|uniprotkb:Q9UKG5|uniprotkb:Q9P1Q7|uniprotkb:B3KQC2|ensembl:ENSP00000331816|ensembl:ENSP00000379842|ensembl:ENSP00000430256|ensembl:ENSP00000430463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgk3_human(display_long)|uniprotkb:SGKL(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 3(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase-like(gene name synonym)|uniprotkb:SGK3(gene name)|psi-mi:SGK3(display_short)|uniprotkb:CISK(gene name synonym)|uniprotkb:Cytokine-independent survival kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028750.1|refseq:NP_001191102.1|refseq:NP_037389.4|refseq:NP_733827.2|ensembl:ENSG00000104205(gene)|ensembl:ENST00000345714(transcript)|ensembl:ENST00000521198(transcript)|ensembl:ENST00000522398(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|ensembl:ENST00000396596(transcript)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001683(Phox-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR036871|interpro:IPR037709|interpro:IPR037900|mint:Q96BR1|rcsb pdb:6EDX|reactome:R-HSA-2672351|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H3ibqrLkptVGc+FDFmEiMSyKhts9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q68EM7	intact:EBI-1257113	intact:EBI-1642807|uniprotkb:A8K6M6|uniprotkb:Q6ZUS4|uniprotkb:Q7Z2F2|uniprotkb:Q8NDG2|uniprotkb:Q96KS2|uniprotkb:Q96KS3|uniprotkb:Q96SS8|uniprotkb:Q9BVF6|uniprotkb:Q9H8U5|uniprotkb:Q9NW54|intact:EBI-2398436|ensembl:ENSP00000289968|ensembl:ENSP00000500372	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhg17_human(display_long)|uniprotkb:ARHGAP17(gene name)|psi-mi:ARHGAP17(display_short)|uniprotkb:Rho-type GTPase-activating protein 17(gene name synonym)|uniprotkb:RhoGAP interacting with CIP4 homologs protein 1(gene name synonym)|uniprotkb:MSTP066(orf name)|uniprotkb:MSTP110(orf name)|uniprotkb:RICH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001006635.1|refseq:NP_060524.4|ensembl:ENSG00000140750(gene)|ensembl:ENSG00000288353(gene)|ensembl:ENST00000289968(transcript)|ensembl:ENST00000673560(transcript)|go:"GO:0005096"(GTPase activator activity)|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013423|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035020"(regulation of Rac protein signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ShqZATP0+ROgRhy0Afi5gqZ1JVY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92538	intact:EBI-1257113	intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6QNY1	intact:EBI-1257113	intact:EBI-465872|ensembl:ENSP00000359398|uniprotkb:Q5W040|uniprotkb:Q8WUI8|uniprotkb:B4DQV2	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bl1s2_human(display_long)|uniprotkb:BLOC1S2(gene name)|psi-mi:BLOC1S2(display_short)|uniprotkb:BLOS2(gene name synonym)|uniprotkb:CEAP(gene name synonym)|uniprotkb:Centrosome-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016197"(endosomal transport)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|ensembl:ENSG00000196072(gene)|go:"GO:0032418"(lysosome localization)|ensembl:ENST00000370372(transcript)|go:"GO:0032438"(melanosome organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005634"(nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0099078"(BORC complex)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR019269|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008022"(protein C-terminus binding)|refseq:NP_776170.2|refseq:NP_001001342.1|refseq:NP_001269366.1|refseq:NP_001269367.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UFYvRoJEOtMQZa5OEOCt2gHLOm89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13671	intact:EBI-1257113	intact:EBI-366017|uniprotkb:O15010|uniprotkb:Q00427|uniprotkb:Q96CC8|ensembl:ENSP00000310406	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rin1_human(display_long)|uniprotkb:RIN1(gene name)|psi-mi:RIN1(display_short)|uniprotkb:Ras interaction/interference protein 1(gene name synonym)|uniprotkb:Ras inhibitor JC99(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000174791(gene)|ensembl:ENST00000311320(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR036860|interpro:IPR037191|reactome:R-HSA-8876198|refseq:NP_004283.2|dip:DIP-117N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oj/ZbyM0Oqe0wDMlFbJHCtGzMwA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92572	intact:EBI-1257113	intact:EBI-4289921|uniprotkb:Q6ICQ2|uniprotkb:O00676|uniprotkb:O00727|uniprotkb:Q53XL4|uniprotkb:O00647|uniprotkb:O00721|ensembl:ENSP00000325369	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ap3s1_human(display_long)|uniprotkb:AP3S1(gene name)|psi-mi:AP3S1(display_short)|uniprotkb:Sigma-3A-adaptin(gene name synonym)|uniprotkb:Sigma-adaptin 3a(gene name synonym)|uniprotkb:CLAPS3(gene name synonym)|uniprotkb:AP-3 complex subunit sigma-3A(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit sigma-1(gene name synonym)|uniprotkb:Clathrin-associated/assembly/adaptor protein, small 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000177879(gene)|ensembl:ENST00000316788(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030119"(AP-type membrane coat adaptor complex)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027155|reactome:R-HSA-432722|refseq:NP_001275.1|refseq:NP_001002924.2|refseq:NP_001305019.1|refseq:NP_001305020.1|refseq:NP_001305022.1|refseq:NP_001305023.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fRNNY4ETqt4Qv6CTQqFxeIk8Syc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P78537	intact:EBI-1257113	intact:EBI-348630|uniprotkb:Q6NZ45|uniprotkb:A1L4Q9|ensembl:ENSP00000447537	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bl1s1_human(display_long)|uniprotkb:BLOC1S1(gene name)|psi-mi:BLOC1S1(display_short)|uniprotkb:BLOS1(gene name synonym)|uniprotkb:RT14(gene name synonym)|uniprotkb:GCN5L1(gene name synonym)|uniprotkb:GCN5-like protein 1(gene name synonym)|uniprotkb:Protein RT14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001478.2|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032418"(lysosome localization)|go:"GO:0032438"(melanosome organization)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0099078"(BORC complex)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR009395(GCN5-like 1)|mint:P78537|reactome:R-HSA-432720|reactome:R-HSA-432722|ensembl:ENSG00000135441(gene)|ensembl:ENST00000548925(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016197"(endosomal transport)|go:"GO:0018394"(peptidyl-lysine acetylation)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lntB3izez0HoFLPpiAtPBayt+G49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NRR3	intact:EBI-1257113	intact:EBI-4402367|uniprotkb:B2R622|uniprotkb:Q4KMT9|ensembl:ENSP00000353706|ensembl:ENSP00000378667|ensembl:ENSP00000427421	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:c42s2_human(display_long)|uniprotkb:CDC42SE2(gene name)|psi-mi:CDC42SE2(display_short)|uniprotkb:SPEC2(gene name synonym)|uniprotkb:Small effector of CDC42 protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001033791.1|refseq:NP_064625.1|refseq:XP_016865137.1|refseq:XP_016865138.1|ensembl:ENSG00000158985(gene)|ensembl:ENST00000360515(transcript)|ensembl:ENST00000395246(transcript)|ensembl:ENST00000505065(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042995"(cell projection)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR036936|interpro:IPR039056|reactome:R-HSA-9013148	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pEl93lmAXDnVpRhtIgSleSIjjJs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q4KMP7	intact:EBI-1257113	intact:EBI-4402442|uniprotkb:B9A6L0|uniprotkb:Q6IN54|uniprotkb:Q6P530|uniprotkb:Q71RG7|uniprotkb:Q86VC5|uniprotkb:Q9H8Z2|uniprotkb:Q9NUN6|uniprotkb:Q9UFP2|ensembl:ENSP00000386538	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:tb10b_human(display_long)|uniprotkb:TBC1D10B(gene name)|psi-mi:TBC1D10B(display_short)|uniprotkb:Rab27A-GAP-beta(gene name synonym)|uniprotkb:FP2461(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056342.3|ensembl:ENSG00000169221(gene)|ensembl:ENST00000409939(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|reactome:R-HSA-8854214	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:B3iC6bxsYI7npYmPuaRVztl7ytc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y478	intact:EBI-1257113	intact:EBI-719769|uniprotkb:Q9UBV0|uniprotkb:Q9UE20|uniprotkb:Q9UEX2|uniprotkb:Q9Y6V8|ensembl:ENSP00000229328|ensembl:ENSP00000441369	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:aakb1_human(display_long)|uniprotkb:PRKAB1(gene name)|psi-mi:PRKAB1(display_short)|uniprotkb:AMPK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006244.2|ensembl:ENSG00000111725(gene)|ensembl:ENST00000229328(transcript)|ensembl:ENST00000541640(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0035878"(nail development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:Q9Y478|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|go:"GO:0005654"(nucleoplasm)|refseq:XP_005253966.1|dip:DIP-39736N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QJftPEDhjfudQn6uXn5nWOkchc09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96TA1	intact:EBI-1257113	intact:EBI-2514593|uniprotkb:Q4LE55|uniprotkb:Q5VVW7|intact:EBI-28984656|ensembl:ENSP00000362409|uniprotkb:Q9NT35|uniprotkb:Q9BUS2|uniprotkb:Q5VVW6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:niba2_human(display_long)|uniprotkb:NIBAN2(gene name)|psi-mi:NIBAN2(display_short)|uniprotkb:C9orf88(gene name synonym)|uniprotkb:FAM129B(gene name synonym)|uniprotkb:Meg-3(gene name synonym)|uniprotkb:Melanoma invasion by ERK(gene name synonym)|uniprotkb:Niban-like protein 1(gene name synonym)|uniprotkb:Protein FAM129B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026088|mint:Q96TA1|rcsb pdb:7CTP|ensembl:ENSG00000136830(gene)|ensembl:ENST00000373312(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007411"(axon guidance)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032274"(gonadotropin secretion)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0045296"(cadherin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|refseq:NP_001030611.1|refseq:NP_073744.2|ensembl:ENSP00000362409|ensembl:ENST00000373314|ensembl:ENSP00000362411	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:xdcw2BLz6uu0zyGi/NzvzPLrKUk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13418	intact:EBI-1257113	intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NUP1	intact:EBI-1257113	intact:EBI-465852|uniprotkb:Q96G84|ensembl:ENSP00000318128|uniprotkb:Q6NVY6	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:bl1s4_human(display_long)|uniprotkb:BLOC1S4(gene name)|psi-mi:BLOC1S4(display_short)|uniprotkb:CNO(gene name synonym)|uniprotkb:Protein cappuccino homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0008089"(anterograde axonal transport)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032438"(melanosome organization)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0070527"(platelet aggregation)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR024857|reactome:R-HSA-432722|ensembl:ENSG00000186222(gene)|ensembl:ENST00000320776(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_060836.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:OGP3Nz9cdPa/BmzSDjUtdbg5XpE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NX57	intact:EBI-1257113	intact:EBI-4402507|uniprotkb:Q5T9X5|uniprotkb:Q9NX49|ensembl:ENSP00000267328	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rab20_human(display_long)|uniprotkb:RAB20(gene name)|psi-mi:RAB20(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060287.1|ensembl:ENSG00000139832(gene)|ensembl:ENST00000267328(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041836|reactome:R-HSA-8873719	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:o+FaTu8V7RtUvfu1uSfXvBDmUdA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NEY4	intact:EBI-1257113	intact:EBI-2819359|uniprotkb:Q96EL8|ensembl:ENSP00000272238	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatc2_human(display_long)|uniprotkb:ATP6V1C2(gene name)|psi-mi:ATP6V1C2(display_short)|uniprotkb:Vacuolar proton pump subunit C 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034451.1|refseq:NP_653184.2|refseq:XP_016859234.1|ensembl:ENSG00000143882(gene)|ensembl:ENST00000272238(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:H+hwHCy4W4xN0UP/8v0kXAK7NUA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9BXB4	intact:EBI-1257113	intact:EBI-2514786|intact:EBI-28979243|ensembl:ENSP00000296220|uniprotkb:A8K9I7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:osb11_human(display_long)|uniprotkb:OSBPL11(gene name)|psi-mi:OSBPL11(display_short)|uniprotkb:ORP11(gene name synonym)|uniprotkb:OSBP12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000144909(gene)|ensembl:ENST00000296220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BXB4|rcsb pdb:2D9X|reactome:R-HSA-9013407|ensembl:ENSP00000296220|refseq:NP_073613.2	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KkLAr8dp83zeiK8iQg61QPEm2fs9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y689	intact:EBI-1257113	intact:EBI-4402308|uniprotkb:Q580I5|ensembl:ENSP00000295087	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl5a_human(display_long)|uniprotkb:ARL5A(gene name)|psi-mi:ARL5A(display_short)|uniprotkb:ARFLP5(gene name synonym)|uniprotkb:ARL5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001032251.1|refseq:NP_036229.1|refseq:NP_817114.2|ensembl:ENSG00000162980(gene)|ensembl:ENST00000295087(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:1903292"(protein localization to Golgi membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:1Z6Y|rcsb pdb:1ZJ6|rcsb pdb:2H16|rcsb pdb:2H17	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KPiSmhFkTDGCzT6LtX3wa29mXoM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P62136	intact:EBI-1257113	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99986	intact:EBI-1257113	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14810	intact:EBI-1257113	intact:EBI-2691813|uniprotkb:B2R4R5|uniprotkb:A6NI80|uniprotkb:D3DVN3|uniprotkb:F1T0G1|ensembl:ENSP00000305613	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cplx1_human(display_long)|uniprotkb:Complexin I(gene name synonym)|uniprotkb:Synaphin-2(gene name synonym)|uniprotkb:CPLX1(gene name)|psi-mi:CPLX1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006642.1|ensembl:ENSG00000168993(gene)|ensembl:ENST00000304062(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0030425"(dendrite)|go:"GO:0031201"(SNARE complex)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0044305"(calyx of Held)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070554"(synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR008849(Synaphin)|rcsb pdb:3RK3|rcsb pdb:3RL0|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-888590|dip:DIP-56109N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fLmOGVm1+wD17+eGvRa7ZRErvMk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P52732	intact:EBI-1257113	intact:EBI-355697|uniprotkb:A0AV49|uniprotkb:Q15716|uniprotkb:Q5VWX0|uniprotkb:B2RMV3|ensembl:ENSP00000260731	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kif11_human(display_long)|uniprotkb:KIF11(gene name)|psi-mi:KIF11(display_short)|uniprotkb:EG5(gene name synonym)|uniprotkb:KNSL1(gene name synonym)|uniprotkb:TRIP5(gene name synonym)|uniprotkb:Kinesin-related motor protein Eg5(gene name synonym)|uniprotkb:Kinesin-like spindle protein HKSP(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 5(gene name synonym)|uniprotkb:Kinesin-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004514.2|ensembl:ENSG00000138160(gene)|ensembl:ENST00000260731(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|rcsb pdb:1X88|rcsb pdb:1YRS|rcsb pdb:2FKY|rcsb pdb:2FL2|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR025901|interpro:IPR027417|interpro:IPR036961|rcsb pdb:1II6|rcsb pdb:1Q0B|rcsb pdb:2FL6|rcsb pdb:2FME|rcsb pdb:2G1Q|rcsb pdb:2GM1|rcsb pdb:2IEH|rcsb pdb:2PG2|rcsb pdb:2Q2Y|rcsb pdb:2Q2Z|rcsb pdb:2UYI|rcsb pdb:2UYM|rcsb pdb:2WOG|rcsb pdb:2X2R|rcsb pdb:2X7C|rcsb pdb:2X7D|rcsb pdb:2X7E|rcsb pdb:2XAE|rcsb pdb:3CJO|rcsb pdb:3HQD|rcsb pdb:3K3B|rcsb pdb:3K5E|rcsb pdb:3KEN|rcsb pdb:3L9H|rcsb pdb:3WPN|rcsb pdb:3ZCW|rcsb pdb:4A1Z|rcsb pdb:4A28|rcsb pdb:4A50|rcsb pdb:4A51|rcsb pdb:4A5Y|rcsb pdb:4AP0|rcsb pdb:4AQV|rcsb pdb:4AQW|rcsb pdb:4AS7|rcsb pdb:4B7B|rcsb pdb:4BBG|rcsb pdb:4BXN|rcsb pdb:4CK5|rcsb pdb:4CK6|rcsb pdb:4CK7|rcsb pdb:4ZCA|rcsb pdb:4ZHI|rcsb pdb:5JV3|rcsb pdb:5ZO7|rcsb pdb:5ZO8|rcsb pdb:5ZO9|rcsb pdb:6G6Y|rcsb pdb:6G6Z|rcsb pdb:6HKX|rcsb pdb:6HKY|rcsb pdb:6TA3|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6TLE|rcsb pdb:6TRL|rcsb pdb:6Y1I|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-53686N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YimbfuWYTSuyqgfs2RF8kCx2+xE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P10619	intact:EBI-1257113	intact:EBI-989654|uniprotkb:Q9BW68|uniprotkb:Q561W6|uniprotkb:Q5JZH1|uniprotkb:Q96KJ2|uniprotkb:Q9BR08|ensembl:ENSP00000361537|ensembl:ENSP00000475524|ensembl:ENSP00000493613|ensembl:ENSP00000191018|uniprotkb:B2R798	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppgb_human(display_long)|uniprotkb:Cathepsin A(gene name synonym)|uniprotkb:Carboxypeptidase C(gene name synonym)|uniprotkb:Protective protein for beta-galactosidase(gene name synonym)|uniprotkb:CTSA(gene name)|psi-mi:CTSA(display_short)|uniprotkb:PPGB(gene name synonym)|uniprotkb:Carboxypeptidase L(gene name synonym)|uniprotkb:Protective protein cathepsin A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000064601(gene)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1IVY|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BXN|rcsb pdb:4AZ0|rcsb pdb:4AZ3|rcsb pdb:4CI9|rcsb pdb:4CIA|rcsb pdb:4CIB|rcsb pdb:4MWS|rcsb pdb:4MWT|rcsb pdb:6WIA|reactome:R-HSA-1660662|reactome:R-HSA-2132295|reactome:R-HSA-4085001|reactome:R-HSA-4341670|reactome:R-HSA-6798695|ensembl:ENST00000191018(transcript)|ensembl:ENST00000372459(transcript)|ensembl:ENST00000607482(transcript)|ensembl:ENST00000646241(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006508"(proteolysis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|refseq:NP_000299.2|refseq:NP_001161066.1|refseq:NP_001121167.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:l/CZaKjZTuZu1ROoJJZVsxobYrQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96ED9	intact:EBI-1257113	intact:EBI-743290|uniprotkb:O60562|ensembl:ENSP00000380785	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hook2_human(display_long)|uniprotkb:HOOK2(gene name)|psi-mi:HOOK2(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001093646.1|refseq:NP_037444.2|ensembl:ENSG00000095066(gene)|ensembl:ENST00000397668(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q96ED9	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ryVqr8ZYjAc5SuoRR/zMQxnh0O89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96EY5	intact:EBI-1257113	intact:EBI-4290865|uniprotkb:Q96I18|ensembl:ENSP00000324810|ensembl:ENSP00000444653	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:mb12a_human(display_long)|uniprotkb:MVB12A(gene name)|psi-mi:MVB12A(display_short)|uniprotkb:CFBP(gene name synonym)|uniprotkb:CIN85/CD2AP family-binding protein(gene name synonym)|uniprotkb:ESCRT-I complex subunit MVB12A(gene name synonym)|uniprotkb:FAM125A(gene name synonym)|uniprotkb:Protein FAM125A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_612410.1|ensembl:ENSG00000141971(gene)|ensembl:ENST00000317040(transcript)|ensembl:ENST00000543795(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019075"(virus maturation)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR018798|interpro:IPR023340|interpro:IPR023341|interpro:IPR040335|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KkN1uSvXWKl0oOX7GhP44l2MpBY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H089	intact:EBI-1257113	intact:EBI-4402486|uniprotkb:A0JLT4|uniprotkb:A0PJK3|uniprotkb:A6NI18|uniprotkb:Q7L9H8|uniprotkb:Q9NUK8|ensembl:ENSP00000265245	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:lsg1_human(display_long)|uniprotkb:LSG1(gene name)|psi-mi:LSG1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060855.2|ensembl:ENSG00000041802(gene)|ensembl:ENST00000265245(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051168"(nuclear export)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:Q9H089|rcsb pdb:6LSR	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:66YYrxhw+MOGH9+lyrsQ4JPDA3w9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UKL6	intact:EBI-1257113	intact:EBI-4402391|uniprotkb:Q9BSC9|uniprotkb:Q9UIT3|uniprotkb:Q9UKW7|ensembl:ENSP00000268896	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ppct_human(display_long)|uniprotkb:StAR-related lipid transfer protein 2(gene name synonym)|uniprotkb:PCTP(gene name)|psi-mi:PCTP(display_short)|uniprotkb:STARD2(gene name synonym)|uniprotkb:START domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001095872.1|refseq:NP_067036.2|refseq:NP_001317307.1|ensembl:ENSG00000141179(gene)|ensembl:ENST00000268896(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0015914"(phospholipid transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR002913(Lipid-binding START)|interpro:IPR023393|interpro:IPR041950|rcsb pdb:1LN1|rcsb pdb:1LN2|rcsb pdb:1LN3|reactome:R-HSA-1483191|reactome:R-HSA-77289	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:fUjSP1XNMizHJfd2DcLpHJYPja89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9H8W4	intact:EBI-1257113	intact:EBI-742388|ensembl:ENSP00000322373|ensembl:ENSP00000427792	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pkhf2_human(display_long)|uniprotkb:Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains(gene name synonym)|uniprotkb:PLEKHF2(gene name)|psi-mi:PLEKHF2(display_short)|uniprotkb:ZFYVE18(gene name synonym)|uniprotkb:PH and FYVE domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 18(gene name synonym)|uniprotkb:Phafin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	mint:Q9H8W4|ensembl:ENSG00000175895(gene)|ensembl:ENST00000315367(transcript)|ensembl:ENST00000519516(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR037871|refseq:NP_078889.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:frYANUSmDIntPcZwWDW4YCQuMEw9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q6DKK2	intact:EBI-1257113	intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9HBH0	intact:EBI-1257113	intact:EBI-4402415|uniprotkb:Q8WVB1|uniprotkb:Q9NXH6|ensembl:ENSP00000267205	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rhof_human(display_long)|uniprotkb:RHOF(gene name)|psi-mi:RHOF(display_short)|uniprotkb:ARHF(gene name synonym)|uniprotkb:RIF(gene name synonym)|uniprotkb:Rho family GTPase Rif(gene name synonym)|uniprotkb:Rho in filopodia(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061907.2|ensembl:ENSG00000139725(gene)|ensembl:ENST00000267205(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|reactome:R-HSA-6798695|reactome:R-HSA-9035034|interpro:IPR027417	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QUBf+mJDOo14sk8HBLJYMfzXkyc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9Y5J5	intact:EBI-1257113	intact:EBI-1055859|uniprotkb:Q53HD6|uniprotkb:Q8NBW9|intact:EBI-1058401|uniprotkb:B2R5A4|ensembl:ENSP00000356278|ensembl:ENSP00000356280	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:phla3_human(display_long)|uniprotkb:PHLDA3(gene name)|psi-mi:PHLDA3(display_short)|uniprotkb:TIH1(gene name synonym)|uniprotkb:TDAG51/Ipl homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036528.1|ensembl:ENSG00000174307(gene)|ensembl:ENST00000367309(transcript)|ensembl:ENST00000367311(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042832	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:wUC7uNy9Jo7wPNkNGVlusgVC05U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NYR9	intact:EBI-1257113	intact:EBI-3918435|uniprotkb:Q6PK52|uniprotkb:B3KNN0|uniprotkb:Q9NSX1|uniprotkb:A6NCZ5|uniprotkb:Q96KC7|uniprotkb:B4DNM3|ensembl:ENSP00000303580|ensembl:ENSP00000377458|ensembl:ENSP00000377459|ensembl:ENSP00000377463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:kbrs2_human(display_long)|uniprotkb:NKIRAS2(gene name)|psi-mi:NKIRAS2(display_short)|uniprotkb:KBRAS2(gene name synonym)|uniprotkb:I-kappa-B-interacting Ras-like protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001001349.1|refseq:NP_001138399.1|refseq:NP_001138400.1|refseq:NP_001138401.1|refseq:NP_060065.2|refseq:XP_005257308.1|ensembl:ENST00000393880(transcript)|ensembl:ENST00000393881(transcript)|ensembl:ENST00000393885(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|ensembl:ENSG00000168256(gene)|ensembl:ENST00000307641(transcript)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042227|reactome:R-HSA-1810476|reactome:R-HSA-445989|reactome:R-HSA-933542	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:WYBB3lqsGJx/tyLiR9SHwr58khU9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q66K74	intact:EBI-1257113	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q00169	intact:EBI-1257113	intact:EBI-1042490|ensembl:ENSP00000316809	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pipna_human(display_long)|uniprotkb:PITPNA(gene name)|psi-mi:PITPNA(display_short)|uniprotkb:PITPN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006215.1|ensembl:ENSG00000174238(gene)|ensembl:ENST00000313486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0015914"(phospholipid transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:1901611"(phosphatidylglycerol binding)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR023393|rcsb pdb:1UW5|reactome:R-HSA-418890|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:KMZulqZC4p4zElJFjDS448WYFnI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8N5K1	intact:EBI-1257113	intact:EBI-1045797|uniprotkb:Q7Z3D5|ensembl:ENSP00000273986	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:cisd2_human(display_long)|uniprotkb:CDGSH2(gene name synonym)|uniprotkb:ERIS(gene name synonym)|uniprotkb:ZCD2(gene name synonym)|uniprotkb:Endoplasmic reticulum intermembrane small protein(gene name synonym)|uniprotkb:MitoNEET-related 1 protein(gene name synonym)|uniprotkb:CISD2(gene name)|psi-mi:CISD2(display_short)|uniprotkb:Nutrient-deprivation autophagy factor-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008389.1|ensembl:ENSG00000145354(gene)|ensembl:ENST00000273986(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR018967|interpro:IPR019610|interpro:IPR042216|rcsb pdb:3FNV|rcsb pdb:4OO7|rcsb pdb:4OOA|go:"GO:0005741"(mitochondrial outer membrane)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YxickLtFNLILnuUDAXl1QqFadD09606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96FZ7	intact:EBI-1257113	intact:EBI-1049648|uniprotkb:Q53FU4|uniprotkb:Q9HAE8|uniprotkb:A8K7U0|ensembl:ENSP00000317468	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:chmp6_human(display_long)|uniprotkb:Chromatin-modifying protein 6(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 20(gene name synonym)|uniprotkb:CHMP6(gene name)|psi-mi:CHMP6(display_short)|uniprotkb:VPS20(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_078867.2|ensembl:ENSG00000176108(gene)|ensembl:ENST00000325167(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904902"(ESCRT III complex assembly)|interpro:IPR005024(Snf7)|mint:Q96FZ7|rcsb pdb:2K3W|rcsb pdb:3HTU|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0016020"(membrane)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:UR/trNCJYky7bD9sxvSnCz0FGkg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P51798	intact:EBI-1257113	intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NT62	intact:EBI-1257113	intact:EBI-988094|uniprotkb:Q6PKC5|uniprotkb:Q9H6L9|ensembl:ENSP00000283290	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:atg3_human(display_long)|uniprotkb:Autophagy-related protein 3(gene name synonym)|uniprotkb:Protein PC3-96(gene name synonym)|uniprotkb:ATG3(gene name)|psi-mi:ATG3(display_short)|uniprotkb:APG3(gene name synonym)|uniprotkb:APG3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071933.2|refseq:NP_001265641.1|dip:DIP-35052N|ensembl:ENSG00000144848(gene)|ensembl:ENST00000283290(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4NAW|reactome:R-HSA-1632852	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yKaFEtGlnMydgWQ1aqZJOGHtKRI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P07602	intact:EBI-1257113	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8NEU8	intact:EBI-1257113	intact:EBI-741261|ensembl:ENSP00000258530|uniprotkb:Q8N4R7|uniprotkb:Q9NVL2|uniprotkb:B7Z411|uniprotkb:B7Z4B0|uniprotkb:F5GZG0|uniprotkb:F8W1P5	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:dp13b_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:APPL2(gene name)|psi-mi:APPL2(display_short)|uniprotkb:DIP13B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|ensembl:ENSG00000136044(gene)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|ensembl:ENST00000258530(transcript)|go:"GO:0044354"(macropinosome)|go:"GO:0001726"(ruffle)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q8NEU8|rcsb pdb:4H8S|rcsb pdb:5C5B|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|refseq:NP_060641.2|refseq:XP_016875042.1|refseq:XP_016875041.1|refseq:NP_001238833.1|refseq:NP_001238834.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8T+Y5phqYZ2On/CsfVVsOChSJNM9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27986	intact:EBI-1257113	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95562	intact:EBI-1257113	intact:EBI-4402330|uniprotkb:A8K2R0|uniprotkb:Q6UWR8|ensembl:ENSP00000271375	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sft2b_human(display_long)|uniprotkb:SFT2D2(gene name)|psi-mi:SFT2D2(display_short)|uniprotkb:SFT2 domain-containing protein 2(gene name synonym)|uniprotkb:UNQ512/PRO1027(orf name)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_955376.1|ensembl:ENSG00000213064(gene)|ensembl:ENST00000271375(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007305(Got1-like protein)|interpro:IPR011691(SFT2-like)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:4FBz4OBGxi03A+390vB3171DoYo9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O14653	intact:EBI-1257113	intact:EBI-4401517|uniprotkb:D3DXJ6|uniprotkb:D3DXJ5|uniprotkb:Q96DA5|uniprotkb:Q9BZZ4|uniprotkb:Q8N4B8|ensembl:ENSP00000492751	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:gosr2_human(display_long)|uniprotkb:GOSR2(gene name)|psi-mi:GOSR2(display_short)|uniprotkb:GS27(gene name synonym)|uniprotkb:27 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:Membrin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012529.1|refseq:NP_004278.2|refseq:NP_473363.1|ensembl:ENSG00000108433(gene)|ensembl:ENST00000640051(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|rcsb pdb:3EG9|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811438	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:RWoVhfrHKdtVMlLtb5NRU/R2wRY9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P27449	intact:EBI-1257113	intact:EBI-721179|uniprotkb:Q6FH26|ensembl:ENSP00000329757	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vatl_human(display_long)|uniprotkb:ATP6V0C(gene name)|psi-mi:ATP6V0C(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6L(gene name synonym)|uniprotkb:ATPL(gene name synonym)|uniprotkb:Vacuolar proton pump 16 kDa proteolipid subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185498.1|refseq:NP_001685.1|ensembl:ENSG00000185883(gene)|ensembl:ENST00000330398(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|mint:P27449|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:SENUYPVXYqkUWD9OawRSREg3SZk9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O95159	intact:EBI-1257113	intact:EBI-718439|uniprotkb:O14616|uniprotkb:Q9UID0|uniprotkb:A8K7E9|ensembl:ENSP00000294258	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zfpl1_human(display_long)|uniprotkb:Zinc finger protein MCG4(gene name synonym)|uniprotkb:ZFPL1(gene name)|psi-mi:ZFPL1(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006773.2|ensembl:ENSG00000162300(gene)|ensembl:ENST00000294258(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039043|mint:O95159	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8U/G+YcD/pF1Cg44ghFOW+D8tD89606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q2M389	intact:EBI-1257113	intact:EBI-2563783|uniprotkb:Q8IW61|uniprotkb:Q9NVD6|uniprotkb:Q8N5W7|uniprotkb:Q2NL83|uniprotkb:Q9UPW7|ensembl:ENSP00000328062	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wasc4_human(display_long)|uniprotkb:WASHC4(gene name)|psi-mi:WASHC4(display_short)|uniprotkb:KIAA1033(gene name synonym)|uniprotkb:Strumpellin and WASH-interacting protein(gene name synonym)|uniprotkb:WASH complex subunit SWIP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056090.1|ensembl:ENSG00000136051(gene)|ensembl:ENST00000332180(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0007032"(endosome organization)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0071203"(WASH complex)|go:"GO:0140591"(nuclear envelope budding)|interpro:IPR027307|interpro:IPR028191|interpro:IPR028283|interpro:IPR028282|refseq:NP_001280569.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:APnP9mxAqwzKEoQFGt94Z8Y73t49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q92888	intact:EBI-1257113	intact:EBI-465400|uniprotkb:O00513|uniprotkb:Q8N4J4|uniprotkb:Q96BF4|uniprotkb:Q96F17|uniprotkb:Q9BSB1|uniprotkb:Q6NX52|ensembl:ENSP00000346532	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arhg1_human(display_long)|uniprotkb:ARHGEF1(gene name)|psi-mi:ARHGEF1(display_short)|uniprotkb:115 kDa guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Sub1.5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004697.2|refseq:NP_945328.1|refseq:NP_945353.1|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000076928(gene)|ensembl:ENST00000354532(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q92888|rcsb pdb:1IAP|rcsb pdb:1SHZ|rcsb pdb:3AB3|rcsb pdb:3ODO|rcsb pdb:3ODW|rcsb pdb:3ODX|rcsb pdb:3P6A	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:XIZmflM2cr80ZBD3FO21IDMnInE9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13464	intact:EBI-1257113	intact:EBI-876651|uniprotkb:B0YJ91|uniprotkb:Q2KHM4|uniprotkb:Q59GZ4|ensembl:ENSP00000382697	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:rock1_human(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-35(gene name synonym)|uniprotkb:ROCK1(gene name)|psi-mi:ROCK1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005397.1|dip:DIP-35645N|ensembl:ENSG00000067900(gene)|ensembl:ENST00000399799(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051451"(myoblast migration)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:Q13464|rcsb pdb:1S1C|rcsb pdb:2ESM|rcsb pdb:2ETK|rcsb pdb:2ETR|rcsb pdb:2V55|rcsb pdb:3D9V|rcsb pdb:3NCZ|rcsb pdb:3NDM|rcsb pdb:3O0Z|rcsb pdb:3TV7|rcsb pdb:3TWJ|rcsb pdb:3V8S|rcsb pdb:4L2W|rcsb pdb:4W7P|rcsb pdb:4YVC|rcsb pdb:4YVE|rcsb pdb:5BML|rcsb pdb:5F5P|rcsb pdb:5HVU|rcsb pdb:5KKS|rcsb pdb:5KKT|rcsb pdb:5UZJ|rcsb pdb:5WNE|rcsb pdb:5WNF|rcsb pdb:5WNG|rcsb pdb:5WNH|rcsb pdb:6E9W|rcsb pdb:7JOU|reactome:R-HSA-111465|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5627117|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013407|reactome:R-HSA-9013422|reactome:R-HSA-9679191|reactome:R-HSA-9696264	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:1YIjRC+RHWK9pmiq8kSBFiZcll49606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NXU5	intact:EBI-1257113	intact:EBI-711759|uniprotkb:Q6IAD0|ensembl:ENSP00000433427	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:arl15_human(display_long)|uniprotkb:ADP-ribosylation factor-related protein 2(gene name synonym)|uniprotkb:ARL15(gene name)|psi-mi:ARL15(display_short)|uniprotkb:ARFRP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061960.1|ensembl:ENSG00000185305(gene)|ensembl:ENST00000504924(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR042292	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:8+lfy1NX3BMoln4dph9wrcIm+0M9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UNF0	intact:EBI-1257113	intact:EBI-742503|uniprotkb:O95921|uniprotkb:Q96HV9|uniprotkb:Q9H0D3|uniprotkb:Q9NPN1|uniprotkb:Q9Y4V2|ensembl:ENSP00000385040|ensembl:ENSP00000385372|ensembl:ENSP00000263246	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:pacn2_human(display_long)|uniprotkb:PACSIN2(gene name)|psi-mi:PACSIN2(display_short)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171899.1|refseq:NP_001171900.1|refseq:NP_009160.2|refseq:XP_005261376.1|refseq:XP_016884053.1|ensembl:ENST00000263246(transcript)|ensembl:ENST00000402229(transcript)|ensembl:ENST00000403744(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|ensembl:ENSG00000100266(gene)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9UNF0|rcsb pdb:3ABH|rcsb pdb:3ACO|rcsb pdb:3HAJ|rcsb pdb:3Q0K|reactome:R-HSA-8856828	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:oEGsyQlsPg61RRGLjBdPGKDmkXc9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q99816	intact:EBI-1257113	intact:EBI-346882|uniprotkb:Q9BUM5|ensembl:ENSP00000251968	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:ts101_human(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006283.1|ensembl:ENSP00000251968|dip:DIP-31809N|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006858"(extracellular transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046755"(viral budding)|go:"GO:0046790"(virion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1990182"(exosomal secretion)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|mint:Q99816|rcsb pdb:1KPP|rcsb pdb:1KPQ|rcsb pdb:1M4P|rcsb pdb:1M4Q|rcsb pdb:1S1Q|rcsb pdb:2F0R|rcsb pdb:3IV1|rcsb pdb:3OBQ|rcsb pdb:3OBS|rcsb pdb:3OBU|rcsb pdb:3OBX|rcsb pdb:3P9G|rcsb pdb:3P9H|rcsb pdb:4EJE|rcsb pdb:4YC1|rcsb pdb:4ZNY|rcsb pdb:5VKG|rcsb pdb:6UD0|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9UDY2	intact:EBI-1257113	intact:EBI-1042602|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1|intact:EBI-10989219|ensembl:ENSP00000366453|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001163886.1|refseq:NP_001163887.1|refseq:NP_004808.2|refseq:XP_011517508.1|refseq:XP_011517509.1|refseq:XP_011517510.1|refseq:XP_011517511.1|ensembl:ENSG00000119139(gene)|ensembl:ENST00000377245(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035598|interpro:IPR036028|interpro:IPR036034|mint:Q9UDY2|rcsb pdb:2OSG|rcsb pdb:3E17|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:iN/EF8QWKtekoj5eON764eKAdpg9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q8IZQ1	intact:EBI-1257113	intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:P57105	intact:EBI-1257113	intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission)	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q96RT1	intact:EBI-1257113	intact:EBI-993903|uniprotkb:Q86W38|uniprotkb:Q9NR18|uniprotkb:Q9NW48|uniprotkb:Q9ULJ5|ensembl:ENSP00000284037|uniprotkb:A0AVR1|uniprotkb:B4E3F1|uniprotkb:B7ZLV9|uniprotkb:E9PCR8|uniprotkb:Q1RMD0|uniprotkb:E7EQW9	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:erbin_human(display_long)|uniprotkb:ERBIN(gene name)|psi-mi:ERBIN(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:ERBB2IP(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:KIAA1225(gene name synonym)|uniprotkb:LAP2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001240628.1|refseq:NP_001240630.1|ensembl:ENSG00000112851(gene)|ensembl:ENST00000284037(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045175"(basal protein localization)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1N7T|rcsb pdb:2H3L|rcsb pdb:2QBW|rcsb pdb:3CH8|rcsb pdb:6Q0M|rcsb pdb:6Q0N|rcsb pdb:6Q0U|rcsb pdb:6UBG|rcsb pdb:6UBH|reactome:R-HSA-1227986|reactome:R-HSA-8863795|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013408|reactome:R-HSA-9013106|reactome:R-HSA-9013423|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|refseq:NP_001006600.1|refseq:NP_061165.1|refseq:NP_001240626.1|refseq:NP_001240627.1	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:kITHWAgafb7t7RFgzs5ff7XCL3Y9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q9NP79	intact:EBI-1257113	intact:EBI-740160|uniprotkb:Q5TGM1|uniprotkb:Q6IAE8|uniprotkb:Q9H0R2|uniprotkb:Q9H3K9|uniprotkb:Q9P0Q0|uniprotkb:E1P594|ensembl:ENSP00000356602|uniprotkb:B4DW55|uniprotkb:E7ETQ7	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:vta1_human(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:HSPC228(orf name)|uniprotkb:My012(orf name)|uniprotkb:SKD1-binding protein 1(gene name synonym)|uniprotkb:C6orf55(gene name synonym)|uniprotkb:Dopamine-responsive gene 1 protein(gene name synonym)|uniprotkb:LYST-interacting protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273300.1|refseq:NP_001273301.1|refseq:NP_057569.2|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:4U7E|reactome:R-HSA-162588|reactome:R-HSA-917729|ensembl:ENSG00000009844(gene)|ensembl:ENST00000367630(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046755"(viral budding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LXL|rcsb pdb:2LXM|rcsb pdb:4TXP	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:QIeYrvtJGJ2jWli8PWK9TeO6gus9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:O15400	intact:EBI-1257113	intact:EBI-3221827|ensembl:ENSP00000356918|uniprotkb:Q5SZW2|uniprotkb:Q96ES9|uniprotkb:E1P579	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:stx7_human(display_long)|uniprotkb:STX7(gene name)|psi-mi:STX7(display_short)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000079950(gene)|ensembl:ENST00000367941(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042582"(azurophil granule)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051640"(organelle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0070925"(organelle assembly)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:O15400|refseq:XP_011534480.1|refseq:NP_003560.2|refseq:NP_001313507.1|refseq:NP_001313508.1|refseq:NP_001313509.1|dip:DIP-57384N	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:lFaq26g0qeP7ObMMKexuZamQgps9606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q53GA4	intact:EBI-1257113	intact:EBI-4402464|uniprotkb:O00496|ensembl:ENSP00000319231|ensembl:ENSP00000483602	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:phla2_human(display_long)|uniprotkb:p17-Beckwith-Wiedemann region 1 C(gene name synonym)|uniprotkb:PHLDA2(gene name)|psi-mi:PHLDA2(display_short)|uniprotkb:BWR1C(gene name synonym)|uniprotkb:HLDA2(gene name synonym)|uniprotkb:IPL(gene name synonym)|uniprotkb:Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein(gene name synonym)|uniprotkb:TSSC3(gene name synonym)|uniprotkb:Imprinted in placenta and liver protein(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 3 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4402441|imex:IM-15829-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003302.1|ensembl:ENSG00000181649(gene)|ensembl:ENSG00000274538(gene)|go:"GO:0001890"(placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0009887"(animal organ morphogenesis)|ensembl:ENST00000314222(transcript)|ensembl:ENST00000618418(transcript)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0060721"(regulation of spongiotrophoblast cell proliferation)|go:"GO:0070873"(regulation of glycogen metabolic process)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|go:"GO:1903547"(regulation of growth hormone activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042832	-	-	-	figure legend:Supp. Table 1B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2021/11/30	-	rogid:YtQvWeBEuQZJIaTWOsKouuU+2389606	intact-crc:19B394BEE57D9731	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:17283"	uniprotkb:Q13596	intact:EBI-1257113	intact:EBI-2822329|uniprotkb:O60750|uniprotkb:A8K6T7|uniprotkb:A6NM19|uniprotkb:O60751|uniprotkb:H0Y2M5|uniprotkb:Q6ZRJ8|ensembl:ENSP00000453785	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:snx1_human(display_long)|uniprotkb:SNX1(gene name)|psi-mi:SNX1(display_short)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404601|imex:IM-15829-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003090.2|refseq:NP_683758.1|refseq:NP_001229862.1|ensembl:ENSG00000028528(gene)|ensembl:ENST00000559844(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028660|interpro:IPR034901|mint:Q13596|rcsb pdb:2I4K|rcsb pdb:4FZS|interpro:IPR036871|dip:DIP-398N	-	-	-	figure legend:Fig. 4F|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.4x10^-7(kelvin)	2011/09/14	2014/10/16	-	rogid:nFyxCtQ9gHndLbuCjBiwhyWE5do9606	intact-crc:F4982DE62CC6402E	false	biotin tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:143-272(IPR001683)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:18348"	uniprotkb:P51178	intact:EBI-1257123	intact:EBI-4405387|uniprotkb:Q86VN8|uniprotkb:B3KR14|ensembl:ENSP00000335600	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:plcd1_human(display_long)|uniprotkb:PLCD1(gene name)|psi-mi:PLCD1(display_short)|uniprotkb:Phosphoinositide phospholipase C-delta-1(gene name synonym)|uniprotkb:Phospholipase C-III(gene name synonym)|uniprotkb:Phospholipase C-delta-1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404641|imex:IM-15829-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001124436.1|refseq:NP_006216.2|ensembl:ENSG00000187091(gene)|ensembl:ENST00000334661(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028391|interpro:IPR035892|mint:P51178|reactome:R-HSA-1855204	-	-	-	figure legend:Fig. 4K|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:r/ISyKjJ4YcV2PI1W7yMgs6sbOI9606	intact-crc:220C0B284231C0E3	false	-	sufficient binding region:21..21-130..130(IPR001849)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:17283"	uniprotkb:Q9HBF4	intact:EBI-1257113	intact:EBI-4401611|uniprotkb:Q8WYX7|uniprotkb:Q96K57|uniprotkb:Q9BXP9|uniprotkb:Q9HCI3|uniprotkb:J3KNL9|ensembl:ENSP00000450742	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:zfyv1_human(display_long)|uniprotkb:ZFYVE1(gene name)|psi-mi:ZFYVE1(display_short)|uniprotkb:DFCP1(gene name synonym)|uniprotkb:KIAA1589(gene name synonym)|uniprotkb:TAFF1(gene name synonym)|uniprotkb:ZNFN2A1(gene name synonym)|uniprotkb:Double FYVE-containing protein 1(gene name synonym)|uniprotkb:SR3(gene name synonym)|uniprotkb:Tandem FYVE fingers-1(gene name synonym)|uniprotkb:PP10436(orf name)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404515|imex:IM-15829-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016876862.1|refseq:NP_067083.1|refseq:NP_848535.1|refseq:NP_001268663.1|refseq:NP_001268664.1|ensembl:ENSG00000165861(gene)|ensembl:ENST00000556143(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005811"(lipid droplet)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016236"(macroautophagy)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990462"(omegasome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR027417|interpro:IPR042427	-	-	-	figure legend:Fig. 4D|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:RjtNZQqOYzwdILGqkyavUWHPB5Q9606	intact-crc:334C124B94C96434	false	-	sufficient binding region:715-777(IPR000306)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:17283"	uniprotkb:Q96BR1	intact:EBI-1257113	intact:EBI-2801236|uniprotkb:A8K5W3|uniprotkb:Q9UKG5|uniprotkb:Q9P1Q7|uniprotkb:B3KQC2|ensembl:ENSP00000331816|ensembl:ENSP00000379842|ensembl:ENSP00000430256|ensembl:ENSP00000430463	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:sgk3_human(display_long)|uniprotkb:SGKL(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 3(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase-like(gene name synonym)|uniprotkb:SGK3(gene name)|psi-mi:SGK3(display_short)|uniprotkb:CISK(gene name synonym)|uniprotkb:Cytokine-independent survival kinase(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404524|imex:IM-15829-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001028750.1|refseq:NP_001191102.1|refseq:NP_037389.4|refseq:NP_733827.2|ensembl:ENSG00000104205(gene)|ensembl:ENST00000345714(transcript)|ensembl:ENST00000521198(transcript)|ensembl:ENST00000522398(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0017081"(chloride channel regulator activity)|ensembl:ENST00000396596(transcript)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001683(Phox-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR036871|interpro:IPR037709|interpro:IPR037900|mint:Q96BR1|rcsb pdb:6EDX|reactome:R-HSA-2672351|go:"GO:0106310"(protein serine kinase activity)	-	-	-	figure legend:Fig. 4E|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:H3ibqrLkptVGc+FDFmEiMSyKhts9606	intact-crc:BA21509BCEAABE96	false	-	glutathione s tranferase tag:?-?|sufficient binding region:12-124(IPR001683)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:17283"	uniprotkb:Q96M96	intact:EBI-1257113	intact:EBI-4401039|uniprotkb:Q6ULS2|uniprotkb:Q8TCP6|ensembl:ENSP00000394487|ensembl:ENSP00000433666|ensembl:ENSP00000462623	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:fgd4_human(display_long)|uniprotkb:FGD4(gene name)|psi-mi:FGD4(display_short)|uniprotkb:FRABP(gene name synonym)|uniprotkb:ZFYVE6(gene name synonym)|uniprotkb:Actin filament-binding protein frabin(gene name synonym)|uniprotkb:FGD1-related F-actin-binding protein(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404508|imex:IM-15829-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_640334.2|refseq:NP_001291409.1|refseq:XP_011518857.1|refseq:XP_011518858.1|refseq:NP_001317303.1|refseq:NP_001317302.1|ensembl:ENSG00000139132(gene)|ensembl:ENST00000427716(transcript)|ensembl:ENST00000525053(transcript)|ensembl:ENST00000583694(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035899|interpro:IPR035941|interpro:IPR037742|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-9013148|interpro:IPR017455(Zinc finger, FYVE-related)	-	-	-	figure legend:Fig. 4B|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:K4gzeBUhltm9N1SSPFdtgrmYsu89606	intact-crc:08A2780134827C4E	false	-	sufficient binding region:559-619(IPR000306)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:17283"	uniprotkb:O14964	intact:EBI-1257113	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404500|imex:IM-15829-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:Fig. 4A|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	intact-crc:6EDE0568CFD215CB	false	-	glutathione s tranferase tag:?-?|sufficient binding region:151-220(IPR011011)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:16618"	uniprotkb:O43739	intact:EBI-1257125	intact:EBI-741648|uniprotkb:A4D2N8|ensembl:ENSP00000379967	psi-mi:1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate(display_short)|psi-mi:"CHEBI:16618"(display_long)	psi-mi:cyh3_human(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener 3(gene name synonym)|uniprotkb:General receptor of phosphoinositides 1(gene name synonym)|uniprotkb:CYTH3(gene name)|psi-mi:CYTH3(display_short)|uniprotkb:ARNO3(gene name synonym)|uniprotkb:GRP1(gene name synonym)|uniprotkb:PSCD3(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Catimel et al. (2013)	imex:IM-15829|pubmed:23416715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4404631|imex:IM-15829-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004218.1|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:4KAX|rcsb pdb:6U3E|rcsb pdb:6U3G|reactome:R-HSA-6811438|ensembl:ENSG00000008256(gene)|ensembl:ENST00000396741(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|dip:DIP-60444N	-	-	-	figure legend:Fig. 4J|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/14	2014/10/16	-	rogid:QLicgFt7zvL4QcS1DKGM0ioegoI9606	intact-crc:F5363CDDB0832BCF	false	-	sufficient binding region:264..264-381..381(IPR001849)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)