#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P58340 uniprotkb:P62258 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0114"(x-ray crystallography) Molzan et al. (2012) pubmed:22151054|imex:IM-16746|mint:MINT-8296202|doi:10.1111/j.1742-4658.2011.08445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7595259|mint:MINT-8296207|imex:IM-16746-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|mint:MINT-8296210(identity) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8296209(identity) - comment:"Stoichiometry: 1.2" comment:"Stoichiometry: 2.1" comment:homomint|comment:domino|comment:mint|figure legend:t1 t2 f1b f1c f1d f4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/25 2022/01/21 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:4A68B6DFE1D10A12|rigid:aPQsvgo7F5xA9O8W6H5SE6vVPOs false binding-associated region:29-42(MINT-8296214)|phosphorylated residue:34-34(MINT-8296216) his tag:?-?(MINT-8296223) 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P62258 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0065"(isothermal titration calorimetry) Molzan et al. (2012) pubmed:22151054|imex:IM-16746|mint:MINT-8296202|doi:10.1111/j.1742-4658.2011.08445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7595329|mint:MINT-8296229|imex:IM-16746-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|mint:MINT-8296232(identity) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8296231(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) temp interaction:1.55x10^-6(molar) 2011/11/25 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:51D60F8578CE6049|rigid:aPQsvgo7F5xA9O8W6H5SE6vVPOs false phosphorylated residue:34-34(MINT-8296238)|binding-associated region:29-42(MINT-8296236) his tag:?-?(MINT-8296241) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62258 uniprotkb:P58340 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0065"(isothermal titration calorimetry) Molzan et al. (2012) pubmed:22151054|imex:IM-16746|mint:MINT-8296202|doi:10.1111/j.1742-4658.2011.08445 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7595371|mint:MINT-8296245|imex:IM-16746-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8296248(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|mint:MINT-8296252(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) temp interaction:4.99x10^-6(molar) 2011/11/25 2014/10/16 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:DF1FFAA7060ED0E6|rigid:aPQsvgo7F5xA9O8W6H5SE6vVPOs false his tag:?-?(MINT-8296249) binding-associated region:29-42(MINT-8296255)|phosphorylated residue:34-34(MINT-8296253)|mutation decreasing interaction:33-33(MINT-8296259) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)