#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P54252-1 uniprotkb:P54252-1 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-946068|ensembl:ENSP00000437157 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:"MI:0051"(fluorescence technology) Santambrogio et al. (2012) pubmed:22129356|imex:IM-16745|mint:MINT-8294629|doi:10.1111/j.1742-4658.2011.08438 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7589967|mint:MINT-8294705|imex:IM-16745-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294707(identity) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294723(identity) - isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." figure legend:f2a|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/23 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 intact-crc:394C37E6EC2B4F01|rigid:FYXw4RFd7gWWz0wry5ClDPsXjuU false binding-associated region:1-182(MINT-8294727) binding-associated region:1-182(MINT-8294731) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54252-1 uniprotkb:P54252-1 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-946068|ensembl:ENSP00000437157 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:"MI:0051"(fluorescence technology) Santambrogio et al. (2012) pubmed:22129356|imex:IM-16745|mint:MINT-8294629|doi:10.1111/j.1742-4658.2011.08438 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7590033|mint:MINT-8294905|imex:IM-16745-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294912(identity) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294907(identity) - isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." comment:homomint|comment:domino|comment:mint|figure legend:f2b f2c f2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/23 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 intact-crc:A5B7E76E416DF9BE|rigid:FYXw4RFd7gWWz0wry5ClDPsXjuU false binding-associated region:1-182(MINT-8294913) binding-associated region:1-182(MINT-8294908) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54252-1 uniprotkb:P54252-1 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-946068|ensembl:ENSP00000437157 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:"MI:0051"(fluorescence technology) Santambrogio et al. (2012) pubmed:22129356|imex:IM-16745|mint:MINT-8294629|doi:10.1111/j.1742-4658.2011.08438 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7589990|mint:MINT-8294734|imex:IM-16745-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294740(identity) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294736(identity) - isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." figure legend:f2a|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/23 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 intact-crc:20F0E92E62B88450|rigid:FYXw4RFd7gWWz0wry5ClDPsXjuU false binding-associated region:1-291(MINT-8294741) binding-associated region:1-291(MINT-8294737) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54252-1 uniprotkb:P54252-1 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-946068|ensembl:ENSP00000437157 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:"MI:0051"(fluorescence technology) Santambrogio et al. (2012) pubmed:22129356|imex:IM-16745|mint:MINT-8294629|doi:10.1111/j.1742-4658.2011.08438 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7590073|mint:MINT-8294920|imex:IM-16745-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294927(identity) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294922(identity) - isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." comment:homomint|comment:domino|comment:mint|figure legend:f2b f2c f2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/23 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 intact-crc:13E5F08E59270CE2|rigid:FYXw4RFd7gWWz0wry5ClDPsXjuU false binding-associated region:1-291(MINT-8294928) binding-associated region:1-291(MINT-8294923) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54252-1 uniprotkb:P54252-1 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-946068|ensembl:ENSP00000437157 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Santambrogio et al. (2012) pubmed:22129356|imex:IM-16745|mint:MINT-8294629|doi:10.1111/j.1742-4658.2011.08438 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7590105|mint:MINT-8294824|imex:IM-16745-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294831(identity) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)|mint:MINT-8294831(identity) - isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."|comment:"Stoichiometry: 2.0" isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."|comment:"Stoichiometry: 2.0" figure legend:f5|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/23 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 intact-crc:81354DDD0FCB4084|rigid:VgrLEa8Z4A4ccWQREYnBmP/B79w false binding-associated region:1-182(MINT-8294832) binding-associated region:1-182(MINT-8294832) 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)