#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O70404	uniprotkb:O55012	intact:EBI-1812572|uniprotkb:Q9CRA3	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp8_mouse(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5307048|imex:IM-16604-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR042855|refseq:NP_058074.2|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|mint:O70404|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|rcsb pdb:3ZYM|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0070625"(zymogen granule exocytosis)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.7x10^-5(molar)	2011/12/15	2014/10/16	rogid:FlASa1dAtfBA6eaPSBVKzsK92nk10090	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:22F01551314BC06F|rigid:Z/DTKDMf+gO7JL97gTPUIpqgPhA	false	glutathione s tranferase tag:?-?|sufficient binding region:1-76	his tag:?-?|myc tag:?-?|sufficient binding region:1-289(IPR011417)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55012	uniprotkb:O55012	intact:EBI-915601|uniprotkb:O55011	intact:EBI-915601|uniprotkb:O55011	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5312218|imex:IM-16604-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4B|3d-resolution:1.7A|3d-r-factors:Rworking = 0.1695 Rfree = 0.191|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:C44F8F6711C46987|rigid:aoVHAP0PbsJ+tIvMkJnwZ+OHS5o	false	sufficient binding region:1-264	sufficient binding region:1-264	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70404	uniprotkb:O55012	intact:EBI-1812572|uniprotkb:Q9CRA3	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp8_mouse(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5311523|imex:IM-16604-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR042855|refseq:NP_058074.2|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|mint:O70404|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|rcsb pdb:3ZYM|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0070625"(zymogen granule exocytosis)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C, 7B, 7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:FlASa1dAtfBA6eaPSBVKzsK92nk10090	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:DDD3307A665D4E3B|rigid:Z/DTKDMf+gO7JL97gTPUIpqgPhA	false	mutation disrupting interaction:16-16,23-23|glutathione s tranferase tag:?-?|sufficient binding region:1-76|mutation disrupting interaction:24-24,27-27	mutation disrupting interaction:240-240|necessary binding region:265-289|mutation disrupting interaction:219-219|mutation disrupting interaction:224-224|mutation disrupting interaction:247-247|mutation disrupting interaction:251-251|his tag:?-?|myc tag:?-?|sufficient binding region:1-289(IPR011417)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O55012	uniprotkb:O70404	intact:EBI-915601|uniprotkb:O55011	intact:EBI-1812572|uniprotkb:Q9CRA3	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:vamp8_mouse(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293532|imex:IM-16604-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	interpro:IPR042855|refseq:NP_058074.2|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|mint:O70404|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|rcsb pdb:3ZYM|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0070625"(zymogen granule exocytosis)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A, 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	rogid:FlASa1dAtfBA6eaPSBVKzsK92nk10090	intact-crc:964D9C243D643D0D|rigid:Z/DTKDMf+gO7JL97gTPUIpqgPhA	false	his tag:?-?|myc tag:?-?|sufficient binding region:1-289(IPR011417)	sufficient binding region:10-41|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O55012	uniprotkb:Q15836	intact:EBI-915601|uniprotkb:O55011	intact:EBI-722343|uniprotkb:Q9BRV4|ensembl:ENSP00000054666	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:vamp3_human(display_long)|uniprotkb:Synaptobrevin-3(gene name synonym)|uniprotkb:Cellubrevin(gene name synonym)|uniprotkb:VAMP3(gene name)|psi-mi:VAMP3(display_short)|uniprotkb:SYB3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5303228|imex:IM-16604-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	refseq:NP_004772.1|dip:DIP-56422N|ensembl:ENSG00000049245(gene)|ensembl:ENST00000054666(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903531"(negative regulation of secretion by cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q15836|reactome:R-HSA-1236974|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	rogid:JeCaIwh36OpRqMG0MFnpFZyN6jU9606	intact-crc:6895B2F09777852D|rigid:6Gh4+rfxobbS5kzhFKcJQXA37NM	false	sufficient binding region:1-289(IPR011417)|myc tag:?-?|his tag:?-?	sufficient binding region:1-81|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P63027	uniprotkb:O55012	intact:EBI-520113|uniprotkb:P19065|ensembl:ENSP00000314214|uniprotkb:Q9BUC2	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp2_human(display_long)|uniprotkb:Synaptobrevin-2(gene name synonym)|uniprotkb:VAMP2(gene name)|psi-mi:VAMP2(display_short)|uniprotkb:SYB2(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5303644|imex:IM-16604-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055047.2|ensembl:ENSG00000220205(gene)|ensembl:ENST00000316509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043621"(protein self-association)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63027|rcsb pdb:3FIE|rcsb pdb:3FII|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|reactome:R-HSA-1445148|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-199992|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-264876|reactome:R-HSA-422356|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-449836|reactome:R-HSA-5250955|reactome:R-HSA-5250958|reactome:R-HSA-5250981|reactome:R-HSA-5250982|reactome:R-HSA-5250989|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-888590|reactome:R-HSA-9609523|reactome:R-HSA-9662360|dip:DIP-39072N	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:uuuJXsI5sr7fzjxuBhSYDHJZp9M9606	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:68266B4EB80A81E5|rigid:ooQVXbke3cYwB9MY69J0R/liNSg	false	sufficient binding region:1-96|glutathione s tranferase tag:?-?	his tag:?-?|myc tag:?-?|sufficient binding region:1-289(IPR011417)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O70404	uniprotkb:O55012	intact:EBI-1812572|uniprotkb:Q9CRA3	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp8_mouse(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5306065|imex:IM-16604-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR042855|refseq:NP_058074.2|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|mint:O70404|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|rcsb pdb:3ZYM|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0070625"(zymogen granule exocytosis)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A, 3D, 4D, 7C, 7E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.7x10^-5(molar)	2011/12/15	2014/10/16	rogid:FlASa1dAtfBA6eaPSBVKzsK92nk10090	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:50A4C946E95039F7|rigid:Z/DTKDMf+gO7JL97gTPUIpqgPhA	false	mutation disrupting interaction:16-16,23-23|glutathione s tranferase tag:?-?|sufficient binding region:10-41|mutation disrupting interaction:24-24,27-27	mutation disrupting interaction:219-219|mutation disrupting interaction:244-244|sufficient binding region:1-289(IPR011417)|his tag:?-?|myc tag:?-?|necessary binding region:265-289	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63027	uniprotkb:O55012	intact:EBI-520113|uniprotkb:P19065|ensembl:ENSP00000314214|uniprotkb:Q9BUC2	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp2_human(display_long)|uniprotkb:Synaptobrevin-2(gene name synonym)|uniprotkb:VAMP2(gene name)|psi-mi:VAMP2(display_short)|uniprotkb:SYB2(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5306059|imex:IM-16604-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055047.2|ensembl:ENSG00000220205(gene)|ensembl:ENST00000316509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043621"(protein self-association)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63027|rcsb pdb:3FIE|rcsb pdb:3FII|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|reactome:R-HSA-1445148|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-199992|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-264876|reactome:R-HSA-422356|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-449836|reactome:R-HSA-5250955|reactome:R-HSA-5250958|reactome:R-HSA-5250981|reactome:R-HSA-5250982|reactome:R-HSA-5250989|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-888590|reactome:R-HSA-9609523|reactome:R-HSA-9662360|dip:DIP-39072N	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.8x10^-5(molar)	2011/12/15	2014/10/16	rogid:uuuJXsI5sr7fzjxuBhSYDHJZp9M9606	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:D029B79B41B8F542|rigid:ooQVXbke3cYwB9MY69J0R/liNSg	false	sufficient binding region:1-96|glutathione s tranferase tag:?-?	his tag:?-?|sufficient binding region:1-289(IPR011417)|myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15836	uniprotkb:O55012	intact:EBI-722343|uniprotkb:Q9BRV4|ensembl:ENSP00000054666	intact:EBI-915601|uniprotkb:O55011	psi-mi:vamp3_human(display_long)|uniprotkb:Synaptobrevin-3(gene name synonym)|uniprotkb:Cellubrevin(gene name synonym)|uniprotkb:VAMP3(gene name)|psi-mi:VAMP3(display_short)|uniprotkb:SYB3(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5306061|imex:IM-16604-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004772.1|dip:DIP-56422N|ensembl:ENSG00000049245(gene)|ensembl:ENST00000054666(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903531"(negative regulation of secretion by cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q15836|reactome:R-HSA-1236974|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.6x10^-5(molar)	2011/12/15	2014/10/16	rogid:JeCaIwh36OpRqMG0MFnpFZyN6jU9606	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:FC012C1242769A5B|rigid:6Gh4+rfxobbS5kzhFKcJQXA37NM	false	glutathione s tranferase tag:?-?|sufficient binding region:1-81	myc tag:?-?|his tag:?-?|sufficient binding region:1-289(IPR011417)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55012	uniprotkb:O55012	intact:EBI-915601|uniprotkb:O55011	intact:EBI-915601|uniprotkb:O55011	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5324052|wwpdb:3zyk|imex:IM-16604-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	-	-	-	figure legend:Fig. 4E, Supp. Table 1|3d-resolution:1.8A|3d-r-factors:Rworking = 0.18 Rfree = 0.22|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:5CFC773234E7FCB3|rigid:aoVHAP0PbsJ+tIvMkJnwZ+OHS5o	false	sufficient binding region:1-289	sufficient binding region:1-289	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55012	uniprotkb:O55012	intact:EBI-915601|uniprotkb:O55011	intact:EBI-915601|uniprotkb:O55011	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Miller et al. (2011)	pubmed:22118466|imex:IM-16604	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5312054|wwpdb:3zyl|imex:IM-16604-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	-	-	-	figure legend:Fig. 4E, Supp. Table 1|3d-resolution:1.7A|3d-r-factors:Rworking = 0.1695 Rfree = 0.191|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/15	2014/10/16	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:031941C64645177F|rigid:aoVHAP0PbsJ+tIvMkJnwZ+OHS5o	false	sufficient binding region:1-264	sufficient binding region:1-264	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)