#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IZC7	uniprotkb:P11802	intact:EBI-5278328|uniprotkb:C9JU83|uniprotkb:Q0VDG9|ensembl:ENSP00000319716|ensembl:ENSP00000468049	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:zn101_human(display_long)|uniprotkb:ZNF101(gene name)|psi-mi:ZNF101(display_short)|uniprotkb:Zinc finger protein HZF12(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283871|imex:IM-16628-36	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287878.1|refseq:NP_149981.2|reactome:R-HSA-212436|ensembl:ENSG00000181896(gene)|ensembl:ENST00000318110(transcript)|ensembl:ENST00000592502(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:mZLXs/PbWbfgLzkjwZfoE2c6jy09606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:0486DE729E5A8158|rigid:3gdrHm0coV8SrIkISsThCm64vwk	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P01106	uniprotkb:Q00534	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283167|imex:IM-16628-35	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:20A3DCC8419B269E|rigid:bfSR2lJKa/lYn3qyMu9VkFJuu2U	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P28698	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-5278283|uniprotkb:Q96I71|uniprotkb:Q9NRY0|uniprotkb:Q9UBW2|uniprotkb:M0QXU0|uniprotkb:Q7Z729|ensembl:ENSP00000469493|ensembl:ENSP00000215057	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:mzf1_human(display_long)|uniprotkb:MZF1(gene name)|psi-mi:MZF1(display_short)|uniprotkb:MZF(gene name synonym)|uniprotkb:ZNF42(gene name synonym)|uniprotkb:ZSCAN6(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 6(gene name synonym)|uniprotkb:Zinc finger protein 42(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283443|imex:IM-16628-34	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_003413.2|refseq:NP_932172.1|refseq:NP_001253962.1|ensembl:ENST00000215057(transcript)|ensembl:ENST00000599369(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000099326(gene)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|rcsb pdb:2FI2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:1rq+ga/Uew705r63KlORpqBObbw9606	intact-crc:578214FA683591D0|rigid:8AADqx3NNAXF9bjpSIdFG8JREow	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:Q9H165	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7|uniprotkb:Q66LN6|ensembl:ENSP00000496168	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283535|imex:IM-16628-33	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|refseq:XP_011531211.1|refseq:XP_016859823.1|dip:DIP-45629N|ensembl:ENSG00000119866(gene)|ensembl:ENST00000642384(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001067"(transcription regulatory region nucleic acid binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1904800"(negative regulation of neuron remodeling)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9H165|rcsb pdb:5VTB|rcsb pdb:6KI6|rcsb pdb:6U9Q|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606	intact-crc:F173ABFF34E61592|rigid:5u6F7IwnpEEfp4Qckmuf/sjgxJc	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14980	uniprotkb:Q00534	intact:EBI-521611|intact:EBI-28985993|ensembl:ENSP00000377298|uniprotkb:Q14981|uniprotkb:H0YH75|uniprotkb:Q9BTE9	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:numa1_human(display_long)|uniprotkb:SP-H antigen(gene name synonym)|uniprotkb:NUMA1(gene name)|psi-mi:NUMA1(display_short)|uniprotkb:NUMA(gene name synonym)|uniprotkb:NMP22(gene name synonym)|uniprotkb:Nuclear matrix protein-22(gene name synonym)|uniprotkb:Nuclear mitotic apparatus protein(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5291819|imex:IM-16628-32	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137497(gene)|ensembl:ENST00000393695(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_006176.2|refseq:NP_001273490.1|refseq:XP_006718627.1|dip:DIP-32937N|ensembl:ENST00000351960|ensembl:ENSP00000260051|ensembl:ENST00000358965|ensembl:ENSP00000351851|ensembl:ENSP00000377298|ensembl:ENST00000613205|ensembl:ENSP00000480172|ensembl:ENST00000620566|ensembl:ENSP00000478624|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006997"(nucleus organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0055028"(cortical microtubule)|go:"GO:0055048"(anastral spindle assembly)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061673"(mitotic spindle astral microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097427"(microtubule bundle)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099738"(cell cortex region)|go:"GO:1902365"(positive regulation of protein localization to spindle pole body)|go:"GO:1902846"(positive regulation of mitotic spindle elongation)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905720"(cytoplasmic microtubule bundle)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:1905832"(positive regulation of spindle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR026650|mint:Q14980|rcsb pdb:3RO2|rcsb pdb:5GXW|rcsb pdb:6HC2|rcsb pdb:6QJA|reactome:R-HSA-380320|reactome:R-HSA-68875	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:goAKbcTz6vzGy3T7RlpGPnTCbdk9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:43D7B9AE4E55FAA0|rigid:mLhZxkGnjrpK+WheO+OxV9YTooE	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:Q08050	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283631|imex:IM-16628-31	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1. d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:F0616B46938B3CAC|rigid:CeZRvwXqeLZ8kCcnl1w4EW2Fgd4	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9H4Z2	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2795590|uniprotkb:B4DLG7|uniprotkb:Q548D0|uniprotkb:Q9H684|ensembl:ENSP00000325326	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:zn335_human(display_long)|uniprotkb:ZNF335(gene name)|psi-mi:ZNF335(display_short)|uniprotkb:NRC-interacting factor 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283029|imex:IM-16628-30	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_071378.1|ensembl:ENSG00000198026(gene)|ensembl:ENST00000322927(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-5617472	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:9f3nj4Z9/YtwjpEejHkO4S791Qw9606	intact-crc:5965CFBE91F16D4E|rigid:LjcamkyM/FtTfhah1zdRI927iU0	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q08999	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-971439|ensembl:ENSP00000262133|uniprotkb:Q15073|uniprotkb:Q16084|uniprotkb:Q92812|uniprotkb:B7Z913|uniprotkb:Q8NE70	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:rbl2_human(display_long)|uniprotkb:RBL2(gene name)|psi-mi:RBL2(display_short)|uniprotkb:RB2(gene name synonym)|uniprotkb:Retinoblastoma-related protein 2(gene name synonym)|uniprotkb:130 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:pRb2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5278351|imex:IM-16628-29	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000103479(gene)|ensembl:ENST00000262133(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028308|interpro:IPR028309|interpro:IPR036915|mint:Q08999|rcsb pdb:4XI9|rcsb pdb:5C1D|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-6804114|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-9617828|refseq:NP_005602.3|refseq:NP_001310537.1|dip:DIP-425N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:2/u/ejPv7UkPWeZYyfJpZXf9Roc9606	intact-crc:F9931AFFDD0B80E8|rigid:NcgfG+HzG7CTOYOMUhsOMZmPuIY	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8IZC7	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-5278328|uniprotkb:C9JU83|uniprotkb:Q0VDG9|ensembl:ENSP00000319716|ensembl:ENSP00000468049	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:zn101_human(display_long)|uniprotkb:ZNF101(gene name)|psi-mi:ZNF101(display_short)|uniprotkb:Zinc finger protein HZF12(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283121|imex:IM-16628-28	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001287878.1|refseq:NP_149981.2|reactome:R-HSA-212436|ensembl:ENSG00000181896(gene)|ensembl:ENST00000318110(transcript)|ensembl:ENST00000592502(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:mZLXs/PbWbfgLzkjwZfoE2c6jy09606	intact-crc:9E13877DE01EEA23|rigid:ypDQ6zWFu/iLTt7/mFnanJl/epI	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:P32243	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-954480|uniprotkb:Q6GTV3|uniprotkb:Q9HAW3|uniprotkb:B2RAN5|uniprotkb:Q9P2R1|ensembl:ENSP00000343819|ensembl:ENSP00000386185|ensembl:ENSP00000452336|ensembl:ENSP00000500061	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:otx2_human(display_long)|uniprotkb:Orthodenticle homolog 2(gene name synonym)|uniprotkb:OTX2(gene name)|psi-mi:OTX2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5278204|imex:IM-16628-27	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_068374.1|refseq:NP_758840.1|refseq:NP_001257452.1|refseq:NP_001257453.1|refseq:NP_001257454.1|ensembl:ENSG00000165588(gene)|ensembl:ENST00000339475(transcript)|ensembl:ENST00000408990(transcript)|ensembl:ENST00000555006(transcript)|ensembl:ENST00000673035(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:ceYynldw4n+AnFOVi5L0PONYj609606	intact-crc:28F24D2AB93CB70E|rigid:fLOKPakfi/AaS6rmL9G9SqlDDi4	false	glutathione s tranferase tag:n-n|sufficient binding region:4-303	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28698	uniprotkb:P11802	intact:EBI-5278283|uniprotkb:Q96I71|uniprotkb:Q9NRY0|uniprotkb:Q9UBW2|uniprotkb:M0QXU0|uniprotkb:Q7Z729|ensembl:ENSP00000469493|ensembl:ENSP00000215057	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:mzf1_human(display_long)|uniprotkb:MZF1(gene name)|psi-mi:MZF1(display_short)|uniprotkb:MZF(gene name synonym)|uniprotkb:ZNF42(gene name synonym)|uniprotkb:ZSCAN6(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 6(gene name synonym)|uniprotkb:Zinc finger protein 42(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283775|imex:IM-16628-26	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003413.2|refseq:NP_932172.1|refseq:NP_001253962.1|ensembl:ENST00000215057(transcript)|ensembl:ENST00000599369(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000099326(gene)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|rcsb pdb:2FI2	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1. g|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:1rq+ga/Uew705r63KlORpqBObbw9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:6EA45027F929B932|rigid:h4Ft2Sy8dKIl/kDtSIJM27YFUvM	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UB98	uniprotkb:Q08050	intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231|ensembl:ENSP00000262126	intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2|ensembl:ENSP00000352901	psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short)	psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5282983|imex:IM-16628-25	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881152.1|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|refseq:XP_005258149.1|refseq:XP_005258150.1|ensembl:ENSG00000101745(gene)|ensembl:ENST00000262126(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|refseq:NP_001230017.1|refseq:NP_001230018.1|dip:DIP-36754N|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|interpro:IPR042839|rcsb pdb:3G73|reactome:R-HSA-156711|reactome:R-HSA-69273	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:etb60/sLQAg6in0go8JlQEGA9Os9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:0DDCD89669C97620|rigid:OffwTCskzTXlU8JkHxAr77CO8yI	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:O60902	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-5278206|uniprotkb:O60465|uniprotkb:O60467|uniprotkb:O60903|ensembl:ENSP00000397099	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:shox2_human(display_long)|uniprotkb:SHOX2(gene name)|psi-mi:SHOX2(display_short)|uniprotkb:OG12X(gene name synonym)|uniprotkb:SHOT(gene name synonym)|uniprotkb:Homeobox protein Og12X(gene name synonym)|uniprotkb:Paired-related homeobox protein SHOT(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5282940|imex:IM-16628-24	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001157150.1|refseq:NP_003021.3|refseq:NP_006875.2|refseq:XP_006713791.1|refseq:XP_016862544.1|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060415"(muscle tissue morphogenesis)|go:"GO:0060920"(cardiac pacemaker cell differentiation)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENST00000441443(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003172"(sinoatrial valve development)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|ensembl:ENSG00000168779(gene)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:KGs4JbbEL/J1oITNTQC3K5OF1P89606	intact-crc:DC86314E254DCCDB|rigid:KWQWUOR7zLWovf8W67w52TM0goE	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9P2Y4	uniprotkb:P11802	intact:EBI-3937106|uniprotkb:D3DS16|uniprotkb:Q8IYC1|uniprotkb:Q9BW28|ensembl:ENSP00000354206|ensembl:ENSP00000388558|ensembl:ENSP00000392401|uniprotkb:Q53Y57	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:zn219_human(display_long)|uniprotkb:ZNF219(gene name)|psi-mi:ZNF219(display_short)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5282927|imex:IM-16628-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165804(gene)|ensembl:ENST00000360947(transcript)|ensembl:ENST00000421093(transcript)|ensembl:ENST00000451119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060174"(limb bud formation)|interpro:IPR003980(Histamine H3 receptor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001095142.1|refseq:NP_001095924.1|refseq:NP_057507.2|refseq:XP_006720226.1|refseq:XP_006720227.1|refseq:XP_016876843.1|refseq:XP_016876844.1	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:DAXqcfdII8ou11EGWuB96DmnpGI9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:3AED40CA9434400C|rigid:BfnK2B5ZxeP3vhmGStkX9rFhbDs	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:4-303	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q08050-1	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-866499|ensembl:ENSP00000352901	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5279372|imex:IM-16628-22	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	intact:EBI-866480(foxm1_human)|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 4I|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:18E2A7300D129CD5|rigid:uIcwp6sePM7jmGJlr09V5SK/DtU	false	his tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:345-537|sufficient binding region:529-763	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9BX66	uniprotkb:Q00534	intact:EBI-433642|uniprotkb:A0AED4|uniprotkb:O43857|uniprotkb:Q7LBE5|uniprotkb:Q8IVK0|uniprotkb:Q8IVQ4|uniprotkb:Q96KF3|uniprotkb:Q96KF4|uniprotkb:Q9BX64|uniprotkb:Q9BX65|uniprotkb:Q9P2Q0|uniprotkb:Q9UFT2|uniprotkb:Q9UHN7|uniprotkb:Q9Y338|uniprotkb:A7MD40|uniprotkb:Q5T924|uniprotkb:D3DR42|uniprotkb:A6NEK3|uniprotkb:A6NID8|uniprotkb:A6NJS4|uniprotkb:Q5T923|uniprotkb:Q5T927|uniprotkb:Q5T928|uniprotkb:Q5T929|uniprotkb:Q5T930|uniprotkb:Q5T931|uniprotkb:Q5T932|ensembl:ENSP00000355136|ensembl:ENSP00000360293	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:srbs1_human(display_long)|uniprotkb:KIAA0894(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)|uniprotkb:SORBS1(gene name)|psi-mi:SORBS1(display_short)|uniprotkb:KIAA1296(gene name synonym)|uniprotkb:SH3D5(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292649|imex:IM-16628-21	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001030126.1|refseq:NP_001030127.1|refseq:NP_001030128.1|refseq:NP_001030129.1|refseq:NP_006425.2|refseq:NP_056200.1|refseq:NP_079267.1|refseq:XP_006717652.1|refseq:NP_001277223.1|refseq:NP_001277224.1|refseq:NP_001277225.1|refseq:NP_001277226.1|refseq:NP_001277227.1|rcsb pdb:2O9V|rcsb pdb:4LN2|rcsb pdb:4LNP|reactome:R-HSA-445355|ensembl:ENSG00000095637(gene)|ensembl:ENST00000361941(transcript)|ensembl:ENST00000371247(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016600"(flotillin complex)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:0016363"(nuclear matrix)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR035606|interpro:IPR035610|interpro:IPR035611|interpro:IPR036028|mint:Q9BX66|rcsb pdb:2DL3|rcsb pdb:2ECZ|rcsb pdb:2LJ0|rcsb pdb:2LJ1|rcsb pdb:2MOX|rcsb pdb:2O2W|rcsb pdb:2O31|rcsb pdb:2O9S	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:R2ONicSRiI7w0eCi4m4vbdPekL09606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:C817F5F11BDDED85|rigid:mWnSCC0pwNwbGFPolV93AdfD1hw	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:Q99741	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-374862|uniprotkb:Q8TB30|ensembl:ENSP00000209728|ensembl:ENSP00000497345	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283967|imex:IM-16628-20	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000094804(gene)|ensembl:ENST00000209728(transcript)|ensembl:ENST00000649662(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|mint:Q99741|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:4I5L|rcsb pdb:4I5N|reactome:R-HSA-1362277|reactome:R-HSA-176187|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69205|refseq:NP_001245.1|dip:DIP-28154N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606	intact-crc:A2D08402C879007C|rigid:vYo0V471QIF83SLRnqrrvvVGF48	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:P28749	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5|ensembl:ENSP00000362768	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5278658|imex:IM-16628-19	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR028310|interpro:IPR036915|mint:P28749|rcsb pdb:1H28|rcsb pdb:4YOO|rcsb pdb:4YOS|rcsb pdb:4YOZ|rcsb pdb:5TUV|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-2173796|reactome:R-HSA-6804114|reactome:R-HSA-69205|reactome:R-HSA-69231|ensembl:ENSG00000080839(gene)|ensembl:ENST00000373664(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|dip:DIP-148N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606	intact-crc:478326D39E3303E8|rigid:Jg9r6WPXpV6tlM8mnh13K66qazU	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14493	uniprotkb:P11802	intact:EBI-2696402|uniprotkb:B3KRJ5|ensembl:ENSP00000417686	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5284015|imex:IM-16628-18	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293003.1|refseq:NP_001293004.1|refseq:NP_006518.1|ensembl:ENSG00000163950(gene)|ensembl:ENST00000489418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR026502|interpro:IPR029344|interpro:IPR038294|mint:Q14493|rcsb pdb:2KJM|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-159230|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-57045N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:57B73D946B2D2664|rigid:1d11Xjl9BOP1xCELf/vU8WUnUX0	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:P01106	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283919|imex:IM-16628-17	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	intact-crc:1CFB4BE7FE10E8E7|rigid:LwzBBxzh3G/N85ITEovJ+KJV9oc	false	glutathione s tranferase tag:n-n|sufficient binding region:4-303	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H4L4	uniprotkb:P11802	intact:EBI-2880236|ensembl:ENSP00000314029|ensembl:ENSP00000403712|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283823|imex:IM-16628-16	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161956(gene)|ensembl:ENST00000321337(transcript)|ensembl:ENST00000429205(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016926"(protein desumoylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR037945|interpro:IPR038765|mint:Q9H4L4|reactome:R-HSA-6791226|refseq:NP_056485.2|dip:DIP-47511N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:379BE88EC7E52061|rigid:FokwUHhfCOh1yJQv82r3Z17XfaY	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:4-303	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28749	uniprotkb:P11802	intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5|ensembl:ENSP00000362768	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283679|imex:IM-16628-15	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR028310|interpro:IPR036915|mint:P28749|rcsb pdb:1H28|rcsb pdb:4YOO|rcsb pdb:4YOS|rcsb pdb:4YOZ|rcsb pdb:5TUV|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-2173796|reactome:R-HSA-6804114|reactome:R-HSA-69205|reactome:R-HSA-69231|ensembl:ENSG00000080839(gene)|ensembl:ENST00000373664(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|dip:DIP-148N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:478326D39E3303E8|rigid:Jg9r6WPXpV6tlM8mnh13K66qazU	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:4-303	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q08999	uniprotkb:P11802	intact:EBI-971439|ensembl:ENSP00000262133|uniprotkb:Q15073|uniprotkb:Q16084|uniprotkb:Q92812|uniprotkb:B7Z913|uniprotkb:Q8NE70	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:rbl2_human(display_long)|uniprotkb:RBL2(gene name)|psi-mi:RBL2(display_short)|uniprotkb:RB2(gene name synonym)|uniprotkb:Retinoblastoma-related protein 2(gene name synonym)|uniprotkb:130 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:pRb2(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283583|imex:IM-16628-14	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103479(gene)|ensembl:ENST00000262133(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028308|interpro:IPR028309|interpro:IPR036915|mint:Q08999|rcsb pdb:4XI9|rcsb pdb:5C1D|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-6804114|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-9617828|refseq:NP_005602.3|refseq:NP_001310537.1|dip:DIP-425N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:2/u/ejPv7UkPWeZYyfJpZXf9Roc9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:630643F0A34FEB93|rigid:4XI2XO76oKGGE6FgSigJT99GOco	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H4Z2	uniprotkb:P11802	intact:EBI-2795590|uniprotkb:B4DLG7|uniprotkb:Q548D0|uniprotkb:Q9H684|ensembl:ENSP00000325326	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:zn335_human(display_long)|uniprotkb:ZNF335(gene name)|psi-mi:ZNF335(display_short)|uniprotkb:NRC-interacting factor 1(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5284063|imex:IM-16628-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071378.1|ensembl:ENSG00000198026(gene)|ensembl:ENST00000322927(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-5617472	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:9f3nj4Z9/YtwjpEejHkO4S791Qw9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:C3F096B1EFB50635|rigid:2q3nlk+kLMX1xb8MI2AB7vzcpUM	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:4-303	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q99741	uniprotkb:Q00534	intact:EBI-374862|uniprotkb:Q8TB30|ensembl:ENSP00000209728|ensembl:ENSP00000497345	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283213|imex:IM-16628-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000094804(gene)|ensembl:ENST00000209728(transcript)|ensembl:ENST00000649662(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|mint:Q99741|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:4I5L|rcsb pdb:4I5N|reactome:R-HSA-1362277|reactome:R-HSA-176187|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69205|refseq:NP_001245.1|dip:DIP-28154N	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:3845DD0DB63D6B07|rigid:fvBFRLZdW3lniIuLHGCii6FWD40	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H165	uniprotkb:Q00534	intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7|uniprotkb:Q66LN6|ensembl:ENSP00000496168	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283489|imex:IM-16628-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|refseq:XP_011531211.1|refseq:XP_016859823.1|dip:DIP-45629N|ensembl:ENSG00000119866(gene)|ensembl:ENST00000642384(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001067"(transcription regulatory region nucleic acid binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1904800"(negative regulation of neuron remodeling)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9H165|rcsb pdb:5VTB|rcsb pdb:6KI6|rcsb pdb:6U9Q|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:6BE6F2F04AA27EE9|rigid:dSjljIPbwr75r5J5Gtr9VXheC5c	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q6UB98	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231|ensembl:ENSP00000262126	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283075|imex:IM-16628-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:XP_016881152.1|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|refseq:XP_005258149.1|refseq:XP_005258150.1|ensembl:ENSG00000101745(gene)|ensembl:ENST00000262126(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:etb60/sLQAg6in0go8JlQEGA9Os9606	intact-crc:F91314DDAC1A7FD7|rigid:QYe9AsIs0F62jsmcSEm54mYwdaU	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P06400	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283351|imex:IM-16628-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:7455B43E1DE2FE7F|rigid:4dToys4au84fNLzCxDHULIBDc4g	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q14493	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2696402|uniprotkb:B3KRJ5|ensembl:ENSP00000417686	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283305|imex:IM-16628-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001293003.1|refseq:NP_001293004.1|refseq:NP_006518.1|ensembl:ENSG00000163950(gene)|ensembl:ENST00000489418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR026502|interpro:IPR029344|interpro:IPR038294|mint:Q14493|rcsb pdb:2KJM|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-159230|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-57045N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606	intact-crc:CD22649B15694D1F|rigid:peoDVG9lpJsweGN8glxUhfLe7WU	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9H4L4	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2880236|ensembl:ENSP00000314029|ensembl:ENSP00000403712|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283397|imex:IM-16628-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000161956(gene)|ensembl:ENST00000321337(transcript)|ensembl:ENST00000429205(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016926"(protein desumoylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR037945|interpro:IPR038765|mint:Q9H4L4|reactome:R-HSA-6791226|refseq:NP_056485.2|dip:DIP-47511N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606	intact-crc:AD0EB181B9A14B1A|rigid:u7tYbHVHjSVoOKvRzygSBQ7OErU	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UB98	uniprotkb:P11802	intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231|ensembl:ENSP00000262126	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283727|imex:IM-16628-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881152.1|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|refseq:XP_005258149.1|refseq:XP_005258150.1|ensembl:ENSG00000101745(gene)|ensembl:ENST00000262126(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:etb60/sLQAg6in0go8JlQEGA9Os9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:63864DD2D25E14AC|rigid:qu2gR+fwSjRkL7YMIL6IYT+u53A	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:4-303	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28749	uniprotkb:Q00534	intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5|ensembl:ENSP00000362768	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5283259|imex:IM-16628-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR028310|interpro:IPR036915|mint:P28749|rcsb pdb:1H28|rcsb pdb:4YOO|rcsb pdb:4YOS|rcsb pdb:4YOZ|rcsb pdb:5TUV|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-2173796|reactome:R-HSA-6804114|reactome:R-HSA-69205|reactome:R-HSA-69231|ensembl:ENSG00000080839(gene)|ensembl:ENST00000373664(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|dip:DIP-148N	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:9963B61D19D3370D|rigid:tTU2mBnujIiH8wnUcw17pkvOArk	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9C0J8	uniprotkb:P11802	intact:EBI-712637|uniprotkb:Q6NUQ0|uniprotkb:Q587J1|uniprotkb:Q05DP8|uniprotkb:Q53FG9|uniprotkb:Q9NUL1|uniprotkb:Q69YF7|ensembl:ENSP00000325377	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:wdr33_human(display_long)|uniprotkb:WDR33(gene name)|psi-mi:WDR33(display_short)|uniprotkb:WDC146(gene name synonym)|uniprotkb:WD repeat-containing protein 33(gene name synonym)|uniprotkb:WD repeat-containing protein of 146 kDa(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5282970|imex:IM-16628-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011509738.1|refseq:NP_001006623.1|refseq:NP_060853.3|refseq:NP_001006624.1|ensembl:ENSG00000136709(gene)|ensembl:ENST00000322313(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005581"(collagen trimer)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006301"(postreplication repair)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007283"(spermatogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9C0J8|rcsb pdb:6BLY|rcsb pdb:6BM0|rcsb pdb:6DNH|rcsb pdb:6F9N|rcsb pdb:6FBS|rcsb pdb:6FUW|rcsb pdb:6URG|rcsb pdb:6URO|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:FzGeASJyKaYaqFQfFBYby692REg9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:E7E54BDFC8B04A11|rigid:64BbHCf03+h1e1bdvRgTLZ7Tv4Y	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P08151	uniprotkb:P11802	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5282953|imex:IM-16628-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:8F71578DACC93EC1|rigid:rrm0QZHWmPK4GR/b668M++K7ARE	false	glutathione s tranferase tag:?-?	sufficient binding region:4-303|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802	uniprotkb:Q08050-1	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-866499|ensembl:ENSP00000352901	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5279388|imex:IM-16628-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	intact:EBI-866480(foxm1_human)|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 4I|comment:Cyclin D1/D3 was added as part of a complex  with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	intact-crc:4AD58B2E9EC6840F|rigid:CeZRvwXqeLZ8kCcnl1w4EW2Fgd4	false	sufficient binding region:4-303|glutathione s tranferase tag:n-n	sufficient binding region:345-537|glutathione s tranferase tag:?-?|sufficient binding region:529-763	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P35711	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-3505701|uniprotkb:Q86UK8|uniprotkb:Q8J017|uniprotkb:Q8J018|uniprotkb:Q8J019|uniprotkb:Q8J020|uniprotkb:Q8N1D9|uniprotkb:Q8N7E0|uniprotkb:Q8TEA4|uniprotkb:B7Z8V0|uniprotkb:F5H5B0|ensembl:ENSP00000398273	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:sox5_human(display_long)|uniprotkb:SOX5(gene name)|psi-mi:SOX5(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292976|imex:IM-16628-38	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_008871.3|refseq:NP_694534.1|refseq:NP_821078.1|refseq:NP_001248343.1|refseq:NP_001248344.1|ensembl:ENSG00000134532(gene)|ensembl:ENST00000451604(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:P35711|refseq:NP_001317714.1|refseq:XP_016875385.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:YVl5zcnqafFgRvQt8B79kMtbz+g9606	intact-crc:B448A89CB217815A|rigid:vSUGiEH5It+wiJ3ObRHkJivgDN0	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P16415	uniprotkb:Q00534	intact:EBI-3446693|uniprotkb:Q6P4A9|uniprotkb:A0PJL4|ensembl:ENSP00000340683|uniprotkb:B7Z8D4	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:zn823_human(display_long)|uniprotkb:ZNF823(gene name)|psi-mi:ZNF823(display_short)|uniprotkb:ZFP36(gene name synonym)|uniprotkb:Zinc finger protein ZFP-36(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292885|imex:IM-16628-37	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001073962.1|refseq:NP_001284539.1|refseq:NP_059977.1|ensembl:ENSG00000197933(gene)|ensembl:ENST00000341191(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|refseq:XP_016882430.1|refseq:XP_016882431.1	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:BZcGK54jkZFiEreePPL3Dt4KcZw9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:87F3CA89E9281079|rigid:0zKOccCaK3TK1AKE2TwZQJ+lPIE	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P62995	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-725485|uniprotkb:O15449|uniprotkb:Q15815|uniprotkb:Q64283|uniprotkb:B4DVK2|uniprotkb:D3DNU3|ensembl:ENSP00000416959	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:tra2b_human(display_long)|uniprotkb:TRA2B(gene name)|psi-mi:TRA2B(display_short)|uniprotkb:SFRS10(gene name synonym)|uniprotkb:Transformer-2 protein homolog B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 10(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293310|imex:IM-16628-85	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_004584.1|refseq:XP_005247760.1|refseq:NP_001230808.1|refseq:XP_011511374.1|ensembl:ENSG00000136527(gene)|ensembl:ENST00000453386(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P62995|rcsb pdb:2CQC|rcsb pdb:2KXN|rcsb pdb:2RRA|rcsb pdb:2RRB|reactome:R-HSA-72163|reactome:R-HSA-9013418|reactome:R-HSA-9013422|refseq:XP_016862522.1|dip:DIP-42278N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:6uZGeHEDlIVsb2uPeo+9NoR4tDw9606	intact-crc:D5E7B6D275898FC8|rigid:EBjyylG9KS+P6X1pXp/OoitvaRM	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q01130	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293294|imex:IM-16628-84	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	intact-crc:47D9C9DA93A056C0|rigid:6KliDBCX1pKkGo1McPudXNXeI+Y	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8WXF0	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-5278477|uniprotkb:B2RA22|uniprotkb:Q5T7K0|uniprotkb:Q8WW25|ensembl:ENSP00000414302	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:srs12_human(display_long)|uniprotkb:SRSF12(gene name)|psi-mi:SRSF12(display_short)|uniprotkb:SFRS13B(gene name synonym)|uniprotkb:SFRS19(gene name synonym)|uniprotkb:SRRP35(gene name synonym)|uniprotkb:35 kDa SR repressor protein(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 13B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 19(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293278|imex:IM-16628-83	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_542781.3|refseq:XP_016865781.1|ensembl:ENSG00000154548(gene)|ensembl:ENST00000452027(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034477|interpro:IPR035979	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:tTmxDmeY9WZwFAEUUFgmjP0VJW89606	intact-crc:A16F97246A3C4F5E|rigid:MKvCuPtg7wGjMjexiwP5PY/aaas	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P37275	uniprotkb:Q00534	intact:EBI-2849734|uniprotkb:Q12924|uniprotkb:Q5T968|uniprotkb:Q13800|uniprotkb:Q2KJ05|uniprotkb:B4DJV0|uniprotkb:B4DUW9|uniprotkb:E9PCM7|uniprotkb:F5H4I8|uniprotkb:Q5VZ84|uniprotkb:Q8NB68|intact:EBI-11153310|ensembl:ENSP00000319248	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:zeb1_human(display_long)|uniprotkb:ZEB1(gene name)|psi-mi:ZEB1(display_short)|uniprotkb:AREB6(gene name synonym)|uniprotkb:TCF8(gene name synonym)|uniprotkb:NIL-2-A zinc finger protein(gene name synonym)|uniprotkb:Negative regulator of IL2(gene name synonym)|uniprotkb:Transcription factor 8(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293270|imex:IM-16628-82	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121600.1|refseq:NP_001167565.1|refseq:NP_001167566.1|refseq:NP_110378.3|refseq:NP_001167564.1|refseq:NP_001167567.1|ensembl:ENSG00000148516(gene)|ensembl:ENST00000320985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048856"(anatomical structure development)|go:"GO:0070888"(E-box binding)|interpro:IPR001356(Homeobox)|interpro:IPR008598(Drought induced 19)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2E19|reactome:R-HSA-6785807|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:2QwbT74tbgA6Jec85fGMRYg0EBI9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:1865BB27CC1842FB|rigid:a1BBunjgaV2h5iDBHEKLIA6Ja5Y	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q16629	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293244|imex:IM-16628-81	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	intact-crc:BEE2D73F6F9ABBCA|rigid:0j2vqUpIgl2hUJAy+fBQK19WX+U	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P61371	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-3906896|uniprotkb:P47894|uniprotkb:P20663|ensembl:ENSP00000230658	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:isl1_human(display_long)|uniprotkb:ISL1(gene name)|psi-mi:ISL1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292845|imex:IM-16628-80	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_002193.2|ensembl:ENSP00000230658|ensembl:ENSG00000016082(gene)|ensembl:ENST00000230658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048880"(sensory system development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P61371|reactome:R-HSA-400511|reactome:R-HSA-9010553	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd09606	intact-crc:5FC5434784A3E261|rigid:xoUpzqZOOAs/U0frteZ2O3os//I	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9UPV9	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1105048|ensembl:ENSP00000328998|uniprotkb:Q96B69|uniprotkb:Q63HR0|uniprotkb:E9PDS2|uniprotkb:Q659B5|uniprotkb:J3KNT7	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:trak1_human(display_long)|uniprotkb:Protein Milton(gene name synonym)|uniprotkb:TRAK1(gene name)|psi-mi:TRAK1(display_short)|uniprotkb:KIAA1042(gene name synonym)|uniprotkb:OIP106(gene name synonym)|uniprotkb:106 kDa O-GlcNAc transferase-interacting protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293219|imex:IM-16628-79	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000182606(gene)|ensembl:ENST00000327628(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006605"(protein targeting)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0017022"(myosin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044295"(axonal growth cone)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|interpro:IPR022154|mint:Q9UPV9|reactome:R-HSA-6802952|reactome:R-HSA-9013419|reactome:R-HSA-9013425|go:"GO:0030425"(dendrite)|refseq:NP_001252537.1|refseq:NP_055780.2|refseq:NP_001252539.1|refseq:NP_001036111.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:wO1gttlJMJ/4RvsellzkZ2YHGiE9606	intact-crc:08C06EB8E9C1F05D|rigid:tx96p3bhqLOV/hhJ+wES/gO9z2U	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O75113	uniprotkb:Q00534	intact:EBI-5278391|uniprotkb:A7MD49|uniprotkb:Q2YDX1|ensembl:ENSP00000262384	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:n4bp1_human(display_long)|uniprotkb:N4BP1(gene name)|psi-mi:N4BP1(display_short)|uniprotkb:KIAA0615(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293211|imex:IM-16628-78	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694574.3|dip:DIP-41205N|ensembl:ENSG00000102921(gene)|ensembl:ENST00000262384(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003729"(mRNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016605"(PML body)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|interpro:IPR021869|rcsb pdb:6Q3V	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:DjuEYSvNvt5wy7oD2kareuxfDxM9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:9B6F4A5DB4027CCD|rigid:Ogi+Vtno9XFBJicYubsoddxnRDw	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q15910	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-530054|uniprotkb:Q15755|uniprotkb:Q92857|uniprotkb:B2RAQ1|uniprotkb:B3KS30|uniprotkb:B7Z1D6|uniprotkb:B7Z7L6|uniprotkb:Q96FI6|intact:EBI-746496|ensembl:ENSP00000419711|uniprotkb:Q75MG3	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:ezh2_human(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)|uniprotkb:EZH2(gene name)|psi-mi:EZH2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293195|imex:IM-16628-77	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:XP_011514186.1|refseq:NP_001190176.1|refseq:NP_001190177.1|refseq:NP_001190178.1|refseq:NP_004447.2|refseq:NP_694543.1|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|ensembl:ENSG00000106462(gene)|ensembl:ENST00000460911(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0006348"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q15910|rcsb pdb:2C6V|rcsb pdb:4MI0|rcsb pdb:4MI5|rcsb pdb:5GSA|rcsb pdb:5H14|rcsb pdb:5H15|rcsb pdb:5H17|rcsb pdb:5H19|rcsb pdb:5H24|rcsb pdb:5H25|rcsb pdb:5HYN|rcsb pdb:5IJ7|rcsb pdb:5IJ8|rcsb pdb:5LS6|rcsb pdb:5U5T|rcsb pdb:5U62|rcsb pdb:5WG6|rcsb pdb:5WUK|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6P5L|rcsb pdb:6U4Y|rcsb pdb:6WKR|rcsb pdb:7AT8|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|go:"GO:0070734"(histone H3-K27 methylation)|reactome:R-HSA-9710421|go:"GO:0048511"(rhythmic process)|dip:DIP-34002N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:ZjwjEGDmMsyQ/33rYN7PimxvcUk9606	intact-crc:597FFFB346E7EA39|rigid:lihLbUlJEqv3Xjls2FGEAVkcSJU	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6KC79	uniprotkb:Q00534	intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4|ensembl:ENSP00000282516	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym)|uniprotkb:SCC2(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293179|imex:IM-16628-76	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056199.2|refseq:NP_597677.2|refseq:XP_016864819.1|dip:DIP-29199N|ensembl:ENSG00000164190(gene)|ensembl:ENST00000282516(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001656"(metanephros development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|interpro:IPR033031|rcsb pdb:6WG3|rcsb pdb:6WGE|reactome:R-HSA-2470946|interpro:IPR024986	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:71D545DEED83702B|rigid:jRPvbbzbPUw8dcFW7qk4YQhQZRY	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9BQW3	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-5278505|uniprotkb:Q1MTP7|uniprotkb:Q5JY53|uniprotkb:Q9NUB6|uniprotkb:Q9P2A6|ensembl:ENSP00000477023	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:coe4_human(display_long)|uniprotkb:EBF4(gene name)|psi-mi:EBF4(display_short)|uniprotkb:COE4(gene name synonym)|uniprotkb:KIAA1442(gene name synonym)|uniprotkb:Early B-cell factor 4(gene name synonym)|uniprotkb:Olf-1/EBF-like 4(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293171|imex:IM-16628-75	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001103984.1|ensembl:ENSG00000088881(gene)|ensembl:ENST00000609451(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR003523(Transcription factor COE)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR018350|interpro:IPR032200|interpro:IPR032201|interpro:IPR038006|interpro:IPR038173	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:1UiTZxXqCvF6n5MDyZntgB1EBe49606	intact-crc:5A4C2A04A273AFD8|rigid:eIRo6gq0opzTAxYLyDxW6V1vF7A	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NRA8	uniprotkb:Q00534	intact:EBI-301024|uniprotkb:B1AKL2|uniprotkb:Q8NCF2|uniprotkb:Q9H708|uniprotkb:B2RBF1|ensembl:ENSP00000328103|ensembl:ENSP00000380659|intact:EBI-877635|uniprotkb:B1AKL3	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:4et_human(display_long)|uniprotkb:EIF4ENIF1(gene name)|psi-mi:EIF4ENIF1(display_short)|uniprotkb:Eukaryotic translation initiation factor 4E nuclear import factor 1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293163|imex:IM-16628-74	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000328103|ensembl:ENST00000344710|ensembl:ENSP00000342927|ensembl:ENSP00000380659|ensembl:ENSG00000184708(gene)|ensembl:ENST00000330125(transcript)|ensembl:ENST00000397525(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019900"(kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0106289"(negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR018862|mint:Q9NRA8|rcsb pdb:5ANR|rcsb pdb:6F9W|rcsb pdb:6X2R|refseq:NP_001157973.1|refseq:NP_001157974.1|refseq:NP_062817.2|refseq:XP_011528582.1|refseq:XP_011528583.1|refseq:XP_005261743.1|refseq:XP_005261744.1|refseq:XP_005261745.1|refseq:XP_016884353.1	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:4A9mF81S/ePAraruTNYgovUdkT49606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:A164B3E051147CD7|rigid:X51tUq54eOGk2Y7TI1zMnDlibdY	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q07955	uniprotkb:Q00534	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293155|imex:IM-16628-73	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:A6C5BF30F75C3102|rigid:unlg5sq722qnlmV1MHBlsgaLSBE	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q14814	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2829828|uniprotkb:Q5T9U5|uniprotkb:Q14815|uniprotkb:Q5T9U6|uniprotkb:D3DVC0|ensembl:ENSP00000271555	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:mef2d_human(display_long)|uniprotkb:MEF2D(gene name)|psi-mi:MEF2D(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293139|imex:IM-16628-72	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:XP_011507871.1|refseq:NP_005911.1|refseq:XP_016856803.1|refseq:XP_016856804.1|refseq:NP_001258558.1|refseq:XP_005245226.1|refseq:XP_005245227.1|refseq:XP_006711393.1|refseq:XP_006711395.1|refseq:XP_006711396.1|refseq:XP_006711397.1|ensembl:ENSG00000116604(gene)|ensembl:ENST00000348159(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9031628|reactome:R-HSA-9707616|go:"GO:0003700"(DNA-binding transcription factor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:jedvDf/fMyonSO9j1epfMUuj86Y9606	intact-crc:F17543E1D1E754D9|rigid:jItS1vbUUXIFA3MTs4bKw0zwS9k	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q12968	uniprotkb:Q00534	intact:EBI-5278441|uniprotkb:O75211|uniprotkb:Q14516|uniprotkb:Q99840|uniprotkb:Q99841|uniprotkb:Q99842|ensembl:ENSP00000300659	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:nfac3_human(display_long)|uniprotkb:NFATC3(gene name)|psi-mi:NFATC3(display_short)|uniprotkb:NFAT4(gene name synonym)|uniprotkb:NFATx(gene name synonym)|uniprotkb:T-cell transcription factor NFAT4(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293123|imex:IM-16628-71	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004546.1|refseq:NP_775186.1|refseq:NP_775188.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902894"(negative regulation of miRNA transcription)|ensembl:ENSG00000072736(gene)|ensembl:ENST00000346183(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|rcsb pdb:2XRW|rcsb pdb:2XS0|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:YhaCvxbZKhSOtPQqf5dj5XVr8X89606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:98C88774B93D7646|rigid:P/px+NFkt9jMeXYs7Hp8PHllWvQ	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8N5Y2	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2560796|ensembl:ENSP00000312244|uniprotkb:Q9Y5Z8|uniprotkb:Q9UG70|uniprotkb:B7Z227|uniprotkb:B4DUV8|uniprotkb:A6NCU2|uniprotkb:A6NHW8|uniprotkb:A8K165	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:ms3l1_human(display_long)|uniprotkb:MSL3(gene name)|psi-mi:MSL3(display_short)|uniprotkb:MSL3L1(gene name synonym)|uniprotkb:Male-specific lethal-3 protein-like 1(gene name synonym)|uniprotkb:Male-specific lethal-3 homolog 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293115|imex:IM-16628-70	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000005302(gene)|ensembl:ENST00000312196(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR037921|interpro:IPR038217|mint:Q8N5Y2|rcsb pdb:2Y0N|rcsb pdb:3OA6|rcsb pdb:3OB9|reactome:R-HSA-3214847|refseq:NP_001180199.1|refseq:NP_523352.1|refseq:NP_523353.2|refseq:NP_006791.2|refseq:NP_001269103.1|refseq:XP_005274497.1|dip:DIP-56857N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:uZsUcEHPwWI+o+d7aGwhfnxVltA9606	intact-crc:EBDCD4D34E76F0A0|rigid:SzOamooGkb7qrO5u+P0o/PBAPIM	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8IZP0	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293099|imex:IM-16628-69	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:3176ECF86D57E4B1|rigid:gtmAmTv2pkgzaCuh6MVNuKmIKtY	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14186	uniprotkb:Q00534	intact:EBI-749713|uniprotkb:Q8IZL5|uniprotkb:Q5JSB4|uniprotkb:B4DLQ9|ensembl:ENSP00000364519	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:tfdp1_human(display_long)|uniprotkb:E2F dimerization partner 1(gene name synonym)|uniprotkb:DRTF1-polypeptide 1(gene name synonym)|uniprotkb:TFDP1(gene name)|psi-mi:TFDP1(display_short)|uniprotkb:DP1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293091|imex:IM-16628-68	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009042.1|refseq:XP_005268388.1|refseq:XP_005268384.1|dip:DIP-238N|ensembl:ENSG00000198176(gene)|ensembl:ENST00000375370(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008544"(epidermis development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043276"(anoikis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000278"(regulation of DNA biosynthetic process)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028313|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|interpro:IPR038168|mint:Q14186|rcsb pdb:2AZE|rcsb pdb:5GOW|rcsb pdb:5TUU|rcsb pdb:5TUV|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1538133|reactome:R-HSA-1912408|reactome:R-HSA-2173796|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804114|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9661069|reactome:R-HSA-9616222	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:FvCKBqPptRL9BKBmt+F9kA7oU8k9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:52B8CEEB6C7CACF3|rigid:XcgeFX8o3ypoIQk4jexSq01LuNo	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WXF8	uniprotkb:Q00534	intact:EBI-5278558|uniprotkb:Q8NBR2|uniprotkb:Q8NES1|uniprotkb:Q8TAA8|uniprotkb:Q96D35|ensembl:ENSP00000470082|ensembl:ENSP00000471512	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:dedd2_human(display_long)|uniprotkb:DEDD2(gene name)|psi-mi:DEDD2(display_short)|uniprotkb:FLAME3(gene name synonym)|uniprotkb:DED-containing protein FLAME-3(gene name synonym)|uniprotkb:FADD-like anti-apoptotic molecule 3(gene name synonym)|uniprotkb:PSEC0004(orf name)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293107|imex:IM-16628-67	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_579874.1|refseq:NP_001257543.1|refseq:NP_001257544.1|ensembl:ENSG00000160570(gene)|ensembl:ENST00000595337(transcript)|ensembl:ENST00000596251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR038856|mint:Q8WXF8	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:KEvs0YThfzCArmJwoQF/bHHttZk9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:9E6C37D26CE88EAB|rigid:1UDOyXLFQQKJ2pjuDSs8bv7otUI	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P19419	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-726632|ensembl:ENSP00000247161|ensembl:ENSP00000366182|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292963|imex:IM-16628-66	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000126767(gene)|ensembl:ENST00000247161(transcript)|ensembl:ENST00000376983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|refseq:NP_001107595.1|refseq:NP_005220.2|refseq:NP_001244097.1|refseq:XP_016884828.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|mint:P19419|rcsb pdb:1DUX|rcsb pdb:5VVT|reactome:R-HSA-198753|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9634638|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010467"(gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|dip:DIP-36057N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606	intact-crc:FAB7264F2E8DEF0C|rigid:bGtgapFlvatXuTMVEjDlOFZoWNw	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q86U06	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-780319|uniprotkb:Q8ND16|uniprotkb:Q8TB88|uniprotkb:Q8WY40|uniprotkb:Q9BUJ1|uniprotkb:Q9NVV7|uniprotkb:D3DS32|ensembl:ENSP00000352956	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:rbm23_human(display_long)|uniprotkb:RNA-binding motif protein 23(gene name synonym)|uniprotkb:RNA-binding region-containing protein 4(gene name synonym)|uniprotkb:Splicing factor SF2(gene name synonym)|uniprotkb:RBM23(gene name)|psi-mi:RBM23(display_short)|uniprotkb:RNPC4(gene name synonym)|uniprotkb:PP239(orf name)|uniprotkb:CAPER beta(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293037|imex:IM-16628-65	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001070819.1|refseq:NP_001070820.1|refseq:NP_060577.3|refseq:NP_001294973.1|refseq:XP_016876896.1|refseq:XP_016876902.1|ensembl:ENSG00000100461(gene)|ensembl:ENST00000359890(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q86U06|rcsb pdb:2CQ4|rcsb pdb:2DNZ	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:+u0lm/as9TcTOHwwPa2ON0HIiW49606	intact-crc:DCE782CF0BBAA497|rigid:G9pPWJPBeef9d3OWCuY7jWQMdEs	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7Z3K3	uniprotkb:Q00534	intact:EBI-1389308|uniprotkb:O75049|uniprotkb:Q5SZS2|uniprotkb:Q5SZS3|uniprotkb:Q5SZS4|uniprotkb:Q8TDZ7|uniprotkb:Q9Y4X7|uniprotkb:Q3LIC4|uniprotkb:Q5SZS1|intact:EBI-2560449|intact:EBI-11742841|uniprotkb:B4DTP8|uniprotkb:B4DYL9|uniprotkb:B7ZBY5|uniprotkb:E9PM80|intact:EBI-14072025|intact:EBI-17205119|intact:EBI-22321456|intact:EBI-12748249|intact:EBI-16429759|ensembl:ENSP00000271715	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:pogz_human(display_long)|uniprotkb:POGZ(gene name)|psi-mi:POGZ(display_short)|uniprotkb:KIAA0461(gene name synonym)|uniprotkb:Nbla00003(orf name)|uniprotkb:SUHW5(gene name synonym)|uniprotkb:ZNF280E(gene name synonym)|uniprotkb:ZNF635(gene name synonym)|uniprotkb:Suppressor of hairy wing homolog 5(gene name synonym)|uniprotkb:Zinc finger protein 280E(gene name synonym)|uniprotkb:Zinc finger protein 635(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292943|imex:IM-16628-64	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001181866.1|refseq:NP_001181867.1|refseq:NP_055915.2|refseq:NP_665739.3|refseq:NP_997054.1|refseq:XP_016856234.1|refseq:XP_016856235.1|refseq:XP_016856237.1|refseq:XP_016856238.1|refseq:XP_005245056.1|refseq:XP_005245057.1|refseq:XP_005245058.1|refseq:XP_005245062.1|refseq:XP_005245063.1|dip:DIP-38044N|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000143442(gene)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|ensembl:ENST00000271715(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0051382"(kinetochore assembly)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q7Z3K3|rcsb pdb:2E72|rcsb pdb:2N3A|rcsb pdb:6EMP	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:sCOIY8KsHRQtfcoSA9Tixl9yIsc9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:275B0184E4F1D37D|rigid:fPJ0aycisZqwIKpisfCwRphNMW0	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8TAD8	uniprotkb:Q00534	intact:EBI-749336|uniprotkb:Q96SP9|uniprotkb:Q9H9T7|intact:EBI-1046254|ensembl:ENSP00000296215	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:snip1_human(display_long)|uniprotkb:SNIP1(gene name)|psi-mi:SNIP1(display_short)|uniprotkb:FHA domain-containing protein SNIP1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292935|imex:IM-16628-63	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078976.2|ensembl:ENSG00000163877(gene)|ensembl:ENST00000296215(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-38956N|mint:Q8TAD8|rcsb pdb:5Z56|rcsb pdb:5Z57|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:2UWnTY01RhPuUx3PepGug23l11U9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:4AD6002ACA6FC9D7|rigid:faRxnTcTFTienE3yrvScSWPPcRI	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q99941	uniprotkb:Q00534	intact:EBI-2841031|uniprotkb:Q99637|uniprotkb:Q5SSW7|uniprotkb:Q13269|uniprotkb:Q9H3W1|uniprotkb:Q9NPL0|uniprotkb:Q99635|uniprotkb:Q14345|uniprotkb:Q9H3V9|uniprotkb:B0UYX6|uniprotkb:Q14343|ensembl:ENSP00000293709|ensembl:ENSP00000364349|ensembl:ENSP00000404725|ensembl:ENSP00000404814	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:atf6b_human(display_long)|uniprotkb:ATF6B(gene name)|psi-mi:ATF6B(display_short)|uniprotkb:CREBL1(gene name synonym)|uniprotkb:G13(gene name synonym)|uniprotkb:Activating transcription factor 6 beta(gene name synonym)|uniprotkb:Protein G13(gene name synonym)|uniprotkb:cAMP response element-binding protein-related protein(gene name synonym)|uniprotkb:cAMP-responsive element-binding protein-like 1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292951|imex:IM-16628-62	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129625.1|refseq:NP_004372.3|ensembl:ENSG00000168468(gene)|ensembl:ENSG00000213676(gene)|ensembl:ENSG00000228628(gene)|ensembl:ENSG00000234539(gene)|ensembl:ENST00000293709(transcript)|ensembl:ENST00000375203(transcript)|ensembl:ENST00000425571(transcript)|ensembl:ENST00000427136(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035497"(cAMP response element binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029809|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:HEe34jikjdOE5qyUIfTFbAB5g3g9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:6ED3A4CBD3558D52|rigid:MwmChrpbpTQmAGA99PFecLmGbpI	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13118	uniprotkb:Q00534	intact:EBI-1389509|uniprotkb:Q503B2|uniprotkb:B2R794|intact:EBI-3962407|uniprotkb:A8MVH0|uniprotkb:O75411|uniprotkb:L0R4P6|uniprotkb:L0R679|ensembl:ENSP00000285407	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:klf10_human(display_long)|uniprotkb:Transforming growth factor-beta-inducible early growth response protein 1(gene name synonym)|uniprotkb:EGR-alpha(gene name synonym)|uniprotkb:KLF10(gene name)|psi-mi:KLF10(display_short)|uniprotkb:TIEG(gene name synonym)|uniprotkb:TIEG1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292869|imex:IM-16628-61	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027453.1|refseq:NP_005646.1|ensembl:ENSG00000155090(gene)|ensembl:ENST00000285407(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030282"(bone mineralization)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2EPA	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:zn9npr6/dmo7T/4AiUnHQPHR4409606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:86C682E91E4AB290|rigid:Bx4hn2UG4NemB/wXqecnqlY2pQs	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8N2M8	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-751069|uniprotkb:O96026|uniprotkb:Q6UW71|uniprotkb:Q96DX2|uniprotkb:B4DDT8|uniprotkb:F8WAG9|ensembl:ENSP00000375814|ensembl:ENSP00000375815	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:clasr_human(display_long)|uniprotkb:Suppressor of white-apricot homolog 2(gene name synonym)|uniprotkb:CLASRP(gene name)|psi-mi:CLASRP(display_short)|uniprotkb:SWAP2(gene name synonym)|uniprotkb:UNQ2428/PRO4988(orf name)|uniprotkb:SFRS16(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 16(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293326|imex:IM-16628-60	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001265368.1|refseq:NP_008987.2|ensembl:ENSG00000104859(gene)|ensembl:ENST00000391952(transcript)|ensembl:ENST00000391953(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR019147|interpro:IPR040397	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:CVO2beqWR1zvbhfgcMOOjqVXa/Y9606	intact-crc:15DF6728124180CE|rigid:8RkyZ+KmY9OsiTgrOYGy8gOflyA	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q8IYF1	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-741705|uniprotkb:Q9P2V9|intact:EBI-28984306|ensembl:ENSP00000331302	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:eloa2_human(display_long)|uniprotkb:TCEB3B(gene name synonym)|uniprotkb:TCEB3L(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3B(gene name synonym)|uniprotkb:ELOA2(gene name)|psi-mi:ELOA2(display_short)|uniprotkb:RNA polymerase II transcription factor SIII subunit A2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293302|imex:IM-16628-59	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_057511.2|ensembl:ENSG00000206181(gene)|ensembl:ENST00000332567(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0070449"(elongin complex)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|interpro:IPR017923|interpro:IPR035441|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|ensembl:ENSP00000331302	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:DsYQKcSRh99Q2iVBnyfejSM4XZU9606	intact-crc:6B5284BF9B214B33|rigid:ifs/DlqI3AJtTuEx1yk1phsNQXk	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9UMS6	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-3453434|uniprotkb:C6H0M7|uniprotkb:Q9UK89|intact:EBI-9640076|uniprotkb:B2RWP6|uniprotkb:B2Y8J9|uniprotkb:S5XAM4|ensembl:ENSP00000395143	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:synp2_human(display_long)|uniprotkb:SYNPO2(gene name)|psi-mi:SYNPO2(display_short)|uniprotkb:Genethonin-2(gene name synonym)|uniprotkb:Myopodin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293286|imex:IM-16628-58	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001122405.1|refseq:NP_001122406.1|refseq:NP_597734.2|ensembl:ENST00000307142|ensembl:ENSP00000395143|ensembl:ENST00000434046|ensembl:ENSP00000390965|ensembl:ENST00000610556|ensembl:ENSP00000484885|ensembl:ENST00000627783|ensembl:ENSP00000498985|ensembl:ENSP00000306015|refseq:NP_001273683.1|ensembl:ENSG00000172403(gene)|ensembl:ENST00000429713(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0099023"(vesicle tethering complex)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q9UMS6|dip:DIP-47311N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:/M3mn/7+FeorqW2JcdbxjylVyDU9606	intact-crc:33CCDCD78DAC8124|rigid:rB8iA8T1iI7WcadnDT4oav9d4XA	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14693	uniprotkb:Q00534	intact:EBI-5278370|uniprotkb:A8MU38|uniprotkb:F5GY24|uniprotkb:Q53T25|uniprotkb:B7Z858|uniprotkb:D6W506|uniprotkb:B4DET9|uniprotkb:B4DGS4|uniprotkb:B4DGZ6|uniprotkb:B5MC18|uniprotkb:E7ESE7|ensembl:ENSP00000256720	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:lpin1_human(display_long)|uniprotkb:LPIN1(gene name)|psi-mi:LPIN1(display_short)|uniprotkb:KIAA0188(gene name synonym)|uniprotkb:Lipin-1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293262|imex:IM-16628-57	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000401522|ensembl:ENST00000449576|ensembl:ENSP00000397908|ensembl:ENST00000674199|ensembl:ENSP00000501331|ensembl:ENST00000425416|ensembl:ENSP00000256720|ensembl:ENST00000396097|ensembl:ENSP00000379404|ensembl:ENST00000396098|ensembl:ENSP00000379405|refseq:XP_011508636.1|refseq:XP_011508637.1|refseq:XP_011508638.1|refseq:NP_663731.1|refseq:NP_001248356.1|refseq:NP_001248357.1|refseq:NP_001248358.1|refseq:XP_006711933.1|refseq:XP_006711934.1|refseq:XP_006711935.1|refseq:XP_006711937.1|refseq:XP_016859113.1|refseq:XP_016859114.1|refseq:XP_016859117.1|refseq:XP_016859118.1|refseq:XP_016859119.1|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046473"(phosphatidic acid metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903730"(regulation of phosphatidate phosphatase activity)|interpro:IPR007651(Lipin, N-terminal conserved region)|interpro:IPR013209(LNS2, Lipin/Ned1/Smp2)|interpro:IPR026058|interpro:IPR028794|interpro:IPR031315|interpro:IPR031703|interpro:IPR036412|reactome:R-HSA-1483191|reactome:R-HSA-1483213|reactome:R-HSA-4419969|reactome:R-HSA-75109|ensembl:ENSG00000134324(gene)|ensembl:ENST00000256720(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0008195"(phosphatidate phosphatase activity)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:DxAi6Wqj+hqqEsnWMPWFuc6Bkx89606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:E069F75BFD54CCAA|rigid:VepgDBsEROBRiy8QIxBVBuAoBCI	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q05519	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1051785|uniprotkb:Q5T758|uniprotkb:Q8IWE6|ensembl:ENSP00000359988	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:srs11_human(display_long)|uniprotkb:Arginine-rich 54 kDa nuclear protein(gene name synonym)|uniprotkb:SRSF11(gene name)|psi-mi:SRSF11(display_short)|uniprotkb:SFRS11(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 11(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293236|imex:IM-16628-56	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_004759.1|refseq:NP_001177916.1|refseq:XP_011540729.1|ensembl:ENSG00000116754(gene)|ensembl:ENST00000370950(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034447|interpro:IPR035979|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:XP_016858301.1|refseq:XP_016858302.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:F6QVk0M0PqxLXIA1dgWyoFbwFHE9606	intact-crc:D4846D7C3984C252|rigid:MUrY/KyAAKSje0zotR7Z9o+w7F8	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q14202	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2556139|uniprotkb:O15089|ensembl:ENSP00000322845|uniprotkb:D3DVV3|uniprotkb:Q96E26	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:zmym3_human(display_long)|uniprotkb:DXS6673E(gene name synonym)|uniprotkb:KIAA0385(gene name synonym)|uniprotkb:ZNF261(gene name synonym)|uniprotkb:Zinc finger protein 261(gene name synonym)|uniprotkb:ZMYM3(gene name)|psi-mi:ZMYM3(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293228|imex:IM-16628-55	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001164633.1|refseq:NP_005087.1|refseq:NP_963893.1|refseq:XP_011529364.1|ensembl:ENSG00000147130(gene)|ensembl:ENST00000314425(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|mint:Q14202|refseq:NP_001164634.1|refseq:XP_005262366.1|refseq:XP_005262367.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:pNPpauiC3Qk1EB3mevtM9L/+g0A9606	intact-crc:E8984710053359A7|rigid:WrL9adi98bk/xmEFBd52PIhWSdM	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P42568	uniprotkb:Q00534	intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293203|imex:IM-16628-54	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:1DCC3A9DA01FA7F7|rigid:xA64ZXfoRCs2ME5j0pWc3kGSk8o	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O43524	uniprotkb:Q00534	intact:EBI-1644164|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6|uniprotkb:B4DVZ6|ensembl:ENSP00000339527|ensembl:ENSP00000385824	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293187|imex:IM-16628-53	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533930.1|refseq:XP_011533931.1|refseq:XP_005266925.1|refseq:NP_001446.1|refseq:NP_963853.1|refseq:XP_016866075.1|dip:DIP-29723N|ensembl:ENSG00000118689(gene)|ensembl:ENST00000343882(transcript)|ensembl:ENST00000406360(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2K86|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2UZK|rcsb pdb:6MNL|reactome:R-HSA-1181150|reactome:R-HSA-198693|reactome:R-HSA-5674400|reactome:R-HSA-5687128|reactome:R-HSA-6785807|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9614657|reactome:R-HSA-9615017|reactome:R-HSA-9617629|reactome:R-HSA-9617828|reactome:R-HSA-9634638	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	crc64:E5B4E830665A9982	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:6FAEB10C255F06BC|rigid:9d08fxydjH0GLNIzBjtZzEUaMhE	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9BXM0	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1753064|uniprotkb:Q9BXL9|uniprotkb:Q9HCF2|ensembl:ENSP00000326018	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:prax_human(display_long)|uniprotkb:PRX(gene name)|psi-mi:PRX(display_short)|uniprotkb:KIAA1620(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293147|imex:IM-16628-52	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENST00000291825|ensembl:ENSP00000291825|ensembl:ENSP00000326018|ensembl:ENST00000673881|ensembl:ENSP00000501070|ensembl:ENST00000674773|ensembl:ENSP00000502579|refseq:XP_011525473.1|refseq:NP_066007.1|refseq:NP_870998.2|ensembl:ENSG00000105227(gene)|ensembl:ENST00000324001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008366"(axon ensheathment)|go:"GO:0030054"(cell junction)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0043484"(regulation of RNA splicing)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:4CMZ|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:r//PcVSJCIM+n38f917ORVoktFI9606	intact-crc:F2A5F4CD107E09E7|rigid:8FNjB23lkymkYC+5Q7F26ExsivY	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q00613	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293131|imex:IM-16628-51	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606	intact-crc:9E3D4D7943621776|rigid:xRU4r774EQQ8ZcGDrqw7YUXhx6k	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9UDY2	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1042602|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1|intact:EBI-10989219|ensembl:ENSP00000366453|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293083|imex:IM-16628-50	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001163886.1|refseq:NP_001163887.1|refseq:NP_004808.2|refseq:XP_011517508.1|refseq:XP_011517509.1|refseq:XP_011517510.1|refseq:XP_011517511.1|ensembl:ENSG00000119139(gene)|ensembl:ENST00000377245(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035598|interpro:IPR036028|interpro:IPR036034|mint:Q9UDY2|rcsb pdb:2OSG|rcsb pdb:3E17|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:iN/EF8QWKtekoj5eON764eKAdpg9606	intact-crc:5A1A490791A94621|rigid:PE7d/93pMjPJvkV/M3sa+PBcEeY	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96EB6	uniprotkb:Q00534	intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293067|imex:IM-16628-49	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:h3zVepuhRhzlINCluVuAn71Btjc9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:976FE8C3E20C679C|rigid:Y6P70WWmKSAfKS9jPvhVZWuO8ew	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9ULW0	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1037322|uniprotkb:Q9H1R4|uniprotkb:Q9NRA3|uniprotkb:Q9UFN9|uniprotkb:Q9UL00|uniprotkb:Q9Y2M1|intact:EBI-2554635|uniprotkb:Q96RR5|intact:EBI-28976825|ensembl:ENSP00000300403	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:tpx2_human(display_long)|uniprotkb:TPX2(gene name)|psi-mi:TPX2(display_short)|uniprotkb:C20orf1(gene name synonym)|uniprotkb:C20orf2(gene name synonym)|uniprotkb:DIL2(gene name synonym)|uniprotkb:HCA519(gene name synonym)|uniprotkb:Restricted expression proliferation-associated protein 100(gene name synonym)|uniprotkb:Differentially expressed in cancerous and non-cancerous lung cells 2(gene name synonym)|uniprotkb:Protein fls353(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 519(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 90(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293075|imex:IM-16628-48	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	dip:DIP-36727N|refseq:NP_036244.2|ensembl:ENSP00000300403|ensembl:ENST00000340513|ensembl:ENSP00000341145|refseq:XP_011526999.1|refseq:XP_011527001.1|dip:DIP-46212N|ensembl:ENSG00000088325(gene)|ensembl:ENST00000300403(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006915"(apoptotic process)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043203"(axon hillock)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR009675(Targeting for Xklp2)|interpro:IPR015128(Aurora-A binding)|interpro:IPR027329|interpro:IPR027330|mint:Q9ULW0|rcsb pdb:1OL5|rcsb pdb:3E5A|rcsb pdb:3HA6|rcsb pdb:4C3P|rcsb pdb:5LXM|rcsb pdb:6BJC|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|reactome:R-HSA-6804756|reactome:R-HSA-8854518	psi-mi:"MI:0469"(intact)	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:dQbYLMi2nP9JPEbdDMk4R4arVxw9606	intact-crc:CE0FACA1006E7B19|rigid:ibwbxeTC05RsSRcLtqPkiDzqdfM	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9UBK2	uniprotkb:Q00534	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293059|imex:IM-16628-47	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:EACB3AEF7863D84D|rigid:LA/0VULxo3wWD3nqPS/tBO5Bl+k	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q9Y3M2	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-947308|uniprotkb:Q66GT6|uniprotkb:Q9UIK9|uniprotkb:B2R4S2|ensembl:ENSP00000216029|ensembl:ENSP00000380026	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:cby1_human(display_long)|uniprotkb:CBY1(gene name)|psi-mi:CBY1(display_short)|uniprotkb:C22orf2(gene name synonym)|uniprotkb:CBY(gene name synonym)|uniprotkb:HRIHFB2025(orf name)|uniprotkb:ARB1(gene name synonym)|uniprotkb:PGEA1(gene name synonym)|uniprotkb:PKD2 interactor, Golgi and endoplasmic reticulum-associated 1(gene name synonym)|uniprotkb:PIGEA-14(gene name synonym)|uniprotkb:Cytosolic leucine-rich protein(gene name synonym)|uniprotkb:ARPP-binding protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293028|imex:IM-16628-46	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_056188.1|refseq:NP_001002880.2|dip:DIP-29651N|ensembl:ENSG00000100211(gene)|ensembl:ENST00000216029(transcript)|ensembl:ENST00000396811(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008104"(protein localization)|go:"GO:0016607"(nuclear speck)|go:"GO:0030030"(cell projection organization)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055007"(cardiac muscle cell differentiation)|interpro:IPR028118|mint:Q9Y3M2|rcsb pdb:4WRQ|reactome:R-HSA-3769402	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:RqvyVBe3nAEf0bYnToiVsM5hLhc9606	intact-crc:D63BED458ED371CD|rigid:V7Ha9t/bZFPzFOJSBMNl4N13Ggc	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q14135	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-5278589|uniprotkb:B4DTS7|uniprotkb:Q7L5V0|uniprotkb:Q9BQ78|uniprotkb:J3KN68	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:vgll4_human(display_long)|uniprotkb:VGLL4(gene name)|psi-mi:VGLL4(display_short)|uniprotkb:KIAA0121(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293020|imex:IM-16628-45	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001121691.1|refseq:NP_001121693.1|refseq:NP_001271319.1|refseq:NP_001271320.1|refseq:NP_001121692.1|refseq:NP_055482.2|interpro:IPR006627(Protein of unknown function TDU)|interpro:IPR028184|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005634"(nucleus)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:uV9rqVyw0SMHZrHZTyzqkg3ovEw9606	intact-crc:288D71F4F854BFD9|rigid:2Mf2C+oaXamcCnKyWLOSH7pFABU	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8NBB4	uniprotkb:Q00534	intact:EBI-5292994|uniprotkb:Q3B798|uniprotkb:Q6WLH8|uniprotkb:Q86WS8|ensembl:ENSP00000282326	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:zsca1_human(display_long)|uniprotkb:ZSCAN1(gene name)|psi-mi:ZSCAN1(display_short)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292986|imex:IM-16628-44	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_872378.3|ensembl:ENSG00000152467(gene)|ensembl:ENST00000282326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:WR2G0UBcX3kvOdwdBzRYAEmtJs09606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:59415353FFE7CBC7|rigid:QNx4vIhh1OvgCai41qlIPUX/JPM	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P35638	uniprotkb:Q00534	intact:EBI-742651|ensembl:ENSP00000340671|ensembl:ENSP00000447188|ensembl:ENSP00000494844|uniprotkb:F8VS99	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:ddit3_human(display_long)|uniprotkb:CHOP10(gene name synonym)|uniprotkb:C/EBP-homologous protein(gene name synonym)|uniprotkb:DDIT3(gene name)|psi-mi:DDIT3(display_short)|uniprotkb:CHOP(gene name synonym)|uniprotkb:GADD153(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD153(gene name synonym)|uniprotkb:C/EBP-homologous protein 10(gene name synonym)|uniprotkb:C/EBP zeta(gene name synonym)|uniprotkb:CCAAT/enhancer-binding protein homologous protein(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292927|imex:IM-16628-43	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001181986.1|refseq:NP_004074.2|refseq:NP_001181982.1|refseq:NP_001181983.1|refseq:NP_001181984.1|ensembl:ENSG00000175197(gene)|go:"GO:0001955"(blood vessel maturation)|ensembl:ENST00000346473(transcript)|ensembl:ENST00000547303(transcript)|ensembl:ENST00000623876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006983"(ER overload response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0005770"(late endosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990442"(intrinsic apoptotic signaling pathway in response to nitrosative stress)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:2000016"(negative regulation of determination of dorsal identity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016670(DNA damage-inducible transcript 3)|mint:P35638|reactome:R-HSA-380994|reactome:R-HSA-381183|reactome:R-HSA-9614657|reactome:R-HSA-9633012|reactome:R-HSA-9648895|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|dip:DIP-41589N	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	crc64:31905293FB1FBBE2	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:xyMsMwPwid+S2IYb3H0K0pnUc309606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:FE512BE6D187C089|rigid:tWoK3iya3t9+6CtIEhcLUqEXbYY	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P56693	uniprotkb:Q00534	intact:EBI-1167533|uniprotkb:B4DV62|uniprotkb:Q6FHW7|ensembl:ENSP00000354130|ensembl:ENSP00000380093	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:sox10_human(display_long)|uniprotkb:SOX10(gene name)|psi-mi:SOX10(display_short)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292909|imex:IM-16628-42	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008872.1|ensembl:ENSG00000100146(gene)|ensembl:ENST00000360880(transcript)|ensembl:ENST00000396884(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048469"(cell maturation)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR036910|reactome:R-HSA-9619665	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:AKrWYlZirtToU/lVD3TerSaJyWY9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:47B4C9F5110D2EC6|rigid:bBcfbfDFeXZPGhB1XFaStmQco+8	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:P81877	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-748077|uniprotkb:Q8N2Q2|uniprotkb:Q9BWW6|uniprotkb:Q9Y4T7|uniprotkb:B7Z2L9|uniprotkb:E9PDA8|uniprotkb:B2R5W1|uniprotkb:B7Z1J2|uniprotkb:B7Z665|uniprotkb:D6RH18|uniprotkb:E9PB74|intact:EBI-28967061|ensembl:ENSP00000322977	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:ssbp2_human(display_long)|uniprotkb:Sequence-specific single-stranded-DNA-binding protein 2(gene name synonym)|uniprotkb:SSBP2(gene name)|psi-mi:SSBP2(display_short)|uniprotkb:SSDP2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292901|imex:IM-16628-41	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSP00000322977|ensembl:ENST00000505980|ensembl:ENSP00000423969|ensembl:ENST00000509053|ensembl:ENSP00000422961|ensembl:ENST00000514493|ensembl:ENSP00000426183|ensembl:ENST00000515395|ensembl:ENSP00000424657|refseq:NP_001243661.1|refseq:NP_036578.2|refseq:NP_001243665.1|refseq:NP_001243663.1|refseq:NP_001243664.1|refseq:NP_001243662.1|ensembl:ENSG00000145687(gene)|ensembl:ENST00000320672(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR008116(Sequence-specific single-strand DNA-binding protein)|mint:P81877|rcsb pdb:6IWV|rcsb pdb:6TYD|dip:DIP-29459N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:CMmZPTurp1G6Y2q7GP/pTMlFM549606	intact-crc:64317A028F4B3A27|rigid:5M2uHiAuplajFydhr0SKLp8rKzA	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8NEY8	uniprotkb:Q00534	intact:EBI-474076|uniprotkb:Q86YT2|uniprotkb:Q8IXN3|uniprotkb:Q8TB09|uniprotkb:Q96NB9|uniprotkb:Q9NXL4|uniprotkb:Q9P0P6|uniprotkb:Q9P0R9|uniprotkb:E9PAX8|ensembl:ENSP00000378935|ensembl:ENSP00000479913	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:pphln_human(display_long)|uniprotkb:Gastric cancer antigen Ga50(gene name synonym)|uniprotkb:HSPC206(orf name)|uniprotkb:HSPC232(orf name)|uniprotkb:PPHLN1(gene name)|psi-mi:PPHLN1(display_short)|uniprotkb:CDC7 expression repressor(gene name synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292893|imex:IM-16628-40	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137259.1|refseq:NP_001137260.1|refseq:NP_057572.5|refseq:NP_958846.1|refseq:NP_958847.1|refseq:NP_958848.1|refseq:NP_958923.1|dip:DIP-49051N|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031424"(keratinization)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0097355"(protein localization to heterochromatin)|interpro:IPR028851|mint:Q8NEY8|rcsb pdb:6SWG|ensembl:ENSG00000134283(gene)|ensembl:ENST00000395568(transcript)|ensembl:ENST00000610488(transcript)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:+s8KstGQ7d91qe3DDnpKYMJon7o9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:9EE2285A3BE48DB1|rigid:QMyEB6qTUWOXnaKovgt8d/96QEM	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:O15234	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-299118|ensembl:ENSP00000264645|uniprotkb:A8K8R0	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:casc3_human(display_long)|uniprotkb:CASC3(gene name)|psi-mi:CASC3(display_short)|uniprotkb:MLN51(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 3 protein(gene name synonym)|uniprotkb:Metastatic lymph node gene 51 protein(gene name synonym)|uniprotkb:Protein barentsz(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292877|imex:IM-16628-39	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR018545|interpro:IPR028544|ensembl:ENSG00000108349(gene)|ensembl:ENST00000264645(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|refseq:NP_031385.2|refseq:XP_005257220.1|dip:DIP-33288N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:62nwK5KCrjsyaY7WKPlfUAPhohM9606	intact-crc:75B5CCF2A1FD6B9A|rigid:AjGoiwv3z6p3BPDwIprrxtrY36o	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q15697	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-1210452|uniprotkb:Q9BQ34|uniprotkb:Q53Y68|ensembl:ENSP00000268655|ensembl:ENSP00000460397	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:zn174_human(display_long)|uniprotkb:ZNF174(gene name)|psi-mi:ZNF174(display_short)|uniprotkb:ZSCAN8(gene name synonym)|uniprotkb:AW-1(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 8(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5292860|imex:IM-16628-87	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001027463.1|refseq:NP_003441.1|refseq:NP_001334797.1|interpro:IPR038269|rcsb pdb:1Y7Q|ensembl:ENSG00000103343(gene)|ensembl:ENST00000268655(transcript)|ensembl:ENST00000571936(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027778|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:OotqJnbHr1LkdIoAnKfK0GrXhKo9606	intact-crc:A7B1FF6F434CFECC|rigid:0aF6Kb0Ja0T+N2KHUU5AequeJLM	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534	uniprotkb:Q13595	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	intact:EBI-2685506|uniprotkb:B4DUA9|uniprotkb:B4DQI6|uniprotkb:E9PD75|ensembl:ENSP00000297071	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:tra2a_human(display_long)|uniprotkb:Transformer-2 protein homolog A(gene name synonym)|uniprotkb:TRA2A(gene name)|psi-mi:TRA2A(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5293318|imex:IM-16628-86	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_001269686.1|refseq:NP_001269687.1|refseq:NP_001269688.1|refseq:XP_005249782.1|refseq:NP_037425.1|refseq:XP_016867578.1|refseq:XP_016867579.1|ensembl:ENSG00000164548(gene)|ensembl:ENST00000297071(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q13595	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A, Table 1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	rogid:JvcdzipB7mCy8eV3z8TaVjucLLM9606	intact-crc:A00FEC4042E48500|rigid:vBKFr7+Pv42FZWSEdziTdWN+eqg	false	his tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q08050-1	uniprotkb:Q00534	intact:EBI-866499|ensembl:ENSP00000352901	intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087	psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym)	psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Anders et al. (2011)	pubmed:22094256|imex:IM-16628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5278953|imex:IM-16628-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-866480(foxm1_human)|ensembl:ENSG00000111206(gene)|ensembl:ENST00000359843(transcript)	refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 4H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/01	2014/10/16	rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606	rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606	intact-crc:3AEC6EDD9F0A2928|rigid:uIcwp6sePM7jmGJlr09V5SK/DtU	false	glutathione s tranferase tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)