#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01130	uniprotkb:Q8NBP7	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539337|mint:MINT-8298607|imex:IM-16526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8298609(identity)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8306740(identity)	-	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	comment:homomint|comment:mint|figure legend:st1 sf1 f2 f3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/14	2014/10/16	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	intact-crc:33A56FB0700A4884|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	binding-associated region:276-715(MINT-8298615)	binding-associated region:153-692(MINT-8306743)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01130	uniprotkb:Q8NBP7	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539337|mint:MINT-8298607|imex:IM-16526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8298609(identity)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8298610(identity)	-	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	comment:homomint|comment:mint|figure legend:st1 sf1 f2 f3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/14	2014/10/16	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	intact-crc:33A56FB0700A4884|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	binding-associated region:276-715(MINT-8298615)	binding-associated region:61-152(MINT-8298619)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539406|mint:MINT-8302442|imex:IM-16526-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302445(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302444(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.1 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:750.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:C877CBEF73EC732A|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	binding-associated region:22-789(MINT-8302512)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539454|mint:MINT-8302454|imex:IM-16526-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302459(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302457(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.2 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1020.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:EA5012F7A1B76E90|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	mutation decreasing interaction:647-647(MINT-8302464)|binding-associated region:22-789(MINT-8302515)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539511|mint:MINT-8302469|imex:IM-16526-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302476(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302472(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.3 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:970.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:D908E068B5FC7A21|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	binding-associated region:22-789(MINT-8302518)|mutation decreasing interaction:647-647(MINT-8302473)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539553|mint:MINT-8302498|imex:IM-16526-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302505(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302501(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.5 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2960.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:722F3B807C4CAA2D|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	binding-associated region:22-789(MINT-8302524)|mutation decreasing interaction:656-656(MINT-8302502)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539532|mint:MINT-8302483|imex:IM-16526-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302490(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302486(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.4 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1250.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:41823DB5D80D1536|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	binding-associated region:22-789(MINT-8302521)|mutation decreasing interaction:647-647(MINT-8302487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539607|mint:MINT-8302554|imex:IM-16526-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302561(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302557(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.7 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1940.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:ED00EDF7F466D0CD|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	mutation decreasing interaction:397-397(MINT-8302569)|binding-associated region:240-687(MINT-8302558)|mutation decreasing interaction:396-396(MINT-8302566)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539590|mint:MINT-8302527|imex:IM-16526-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302536(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302530(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.6 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:880.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:33424CBD3775CB5C|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	-	binding-associated region:240-687(MINT-8302531)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NBP7	uniprotkb:P01130	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lo et al. (2011)	pubmed:22081141|imex:IM-16526|mint:MINT-8298560|doi:10.1038/embor.2011.205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7539647|mint:MINT-8302573|imex:IM-16526-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N|mint:MINT-8302584(identity)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N|mint:MINT-8302576(identity)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	comment:homomint|comment:mint|figure legend:sf3.8 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:820.0x10^-9(molar)	2011/12/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	intact-crc:319489FB9913385D|rigid:1NnVnp1kXWqmZazVV1CWMBcADBo	false	binding-associated region:31-451(MINT-8302588)	binding-associated region:240-687(MINT-8302581)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)