#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9XTN2 uniprotkb:P92177 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372317|imex:IM-15821-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:747D8115988A2C0A|rigid:208XHoH+Nr9dgaQuOenO7OmL7WU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:Q9VJ14 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-75248|ensemblmetazoa:FBpp0080686|ensemblmetazoa:FBpp0307801|ensemblmetazoa:FBpp0307802 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:q9vj14_drome(display_long)|uniprotkb:Be(gene name synonym)|uniprotkb:D-mibl(gene name synonym)|uniprotkb:"l(2)37Be"(gene name synonym)|uniprotkb:Dmel\CG17492(gene name synonym)|uniprotkb:Mib-2(gene name synonym)|uniprotkb:i115(gene name synonym)|uniprotkb:mib2(gene name)|psi-mi:mib2(display_short)|uniprotkb:2(gene name synonym)|uniprotkb:mib1(gene name synonym)|uniprotkb:suelto(gene name synonym)|uniprotkb:Dmel_CG17492(orf name)|uniprotkb:CG17492(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372317|imex:IM-15821-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_609933.1|flybase:FBgn0086442|refseq:NP_001260554.1|refseq:NP_001260555.1|ensemblmetazoa:FBgn0086442(gene)|ensemblmetazoa:FBtr0081142(transcript)|ensemblmetazoa:FBtr0336840(transcript)|ensemblmetazoa:FBtr0336841(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0032033"(myosin II light chain binding)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002110(Ankyrin)|interpro:IPR010606(Mib-herc2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037252|interpro:IPR040847|interpro:IPR042056|interpro:IPR043145|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:TzJKkaNS1ber5Pkt5WhevdY0WN07227 intact-crc:747D8115988A2C0A|rigid:208XHoH+Nr9dgaQuOenO7OmL7WU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:O46084 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-182790|intact:EBI-1628297|uniprotkb:Q7K2X2|ensemblmetazoa:FBpp0070350 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:pgam5_drome(display_long)|uniprotkb:Pgam5(gene name)|psi-mi:Pgam5(display_short)|uniprotkb:CG14816(orf name)|uniprotkb:Phosphoglycerate mutase family member 5 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372317|imex:IM-15821-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_569951.1|flybase:FBgn0023517|dip:DIP-18549N|ensemblmetazoa:FBgn0023517(gene)|ensemblmetazoa:FBtr0070366(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|reactome:R-DME-8934903 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:JdwqvkvryuEe5V9+zJ1S6oq3AZ87227 intact-crc:747D8115988A2C0A|rigid:208XHoH+Nr9dgaQuOenO7OmL7WU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:P09208 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372317|imex:IM-15821-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227 intact-crc:747D8115988A2C0A|rigid:208XHoH+Nr9dgaQuOenO7OmL7WU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:P29310 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372317|imex:IM-15821-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:747D8115988A2C0A|rigid:208XHoH+Nr9dgaQuOenO7OmL7WU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:P29310 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372329|imex:IM-15821-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:CFE39432753BCC2A|rigid:I/HIl1BQ+/WVn4EXReghu71lEnc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:P92177 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372329|imex:IM-15821-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:CFE39432753BCC2A|rigid:I/HIl1BQ+/WVn4EXReghu71lEnc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:O18683 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372329|imex:IM-15821-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 intact-crc:CFE39432753BCC2A|rigid:I/HIl1BQ+/WVn4EXReghu71lEnc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:O46084 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-182790|intact:EBI-1628297|uniprotkb:Q7K2X2|ensemblmetazoa:FBpp0070350 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:pgam5_drome(display_long)|uniprotkb:Pgam5(gene name)|psi-mi:Pgam5(display_short)|uniprotkb:CG14816(orf name)|uniprotkb:Phosphoglycerate mutase family member 5 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372329|imex:IM-15821-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_569951.1|flybase:FBgn0023517|dip:DIP-18549N|ensemblmetazoa:FBgn0023517(gene)|ensemblmetazoa:FBtr0070366(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0009408"(response to heat)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|reactome:R-DME-8934903 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:JdwqvkvryuEe5V9+zJ1S6oq3AZ87227 intact-crc:CFE39432753BCC2A|rigid:I/HIl1BQ+/WVn4EXReghu71lEnc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XTN2 uniprotkb:P09208 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671 psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372329|imex:IM-15821-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227 intact-crc:CFE39432753BCC2A|rigid:I/HIl1BQ+/WVn4EXReghu71lEnc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q7JXA2 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q95R60 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372372 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q95r60_drome(display_long)|uniprotkb:CG8060(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 flybase:FBgn0034113|go:"GO:0005654"(nucleoplasm)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR002110(Ankyrin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:N/jAvEaX9Gq1AiilRnkGfPNj6UE7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q8IP45 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372346|ensemblmetazoa:FBpp0291369 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q8ip45_drome(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)|uniprotkb:Cul-3(gene name synonym)|uniprotkb:Cul-3-RF(gene name synonym)|uniprotkb:"BG:DS07851.2"(gene name synonym)|uniprotkb:CUL-3(gene name synonym)|uniprotkb:CUL3(gene name synonym)|uniprotkb:Cullin3(gene name synonym)|uniprotkb:DMcul-3(gene name synonym)|uniprotkb:Dmel\CG42616(gene name synonym)|uniprotkb:br34(gene name synonym)|uniprotkb:cul-3(gene name synonym)|uniprotkb:cul3(gene name synonym)|uniprotkb:dCul-3(gene name synonym)|uniprotkb:dCul3(gene name synonym)|uniprotkb:gft(gene name synonym)|uniprotkb:guftagu(gene name synonym)|uniprotkb:"l(2)06430"(gene name synonym)|uniprotkb:"l(2)35Cd"(gene name synonym)|uniprotkb:CG11861(gene name synonym)|uniprotkb:CG31829(gene name synonym)|uniprotkb:"l(2)br34"(gene name synonym)|uniprotkb:l35Cd(gene name synonym)|uniprotkb:mds(gene name synonym)|uniprotkb:Dmel_CG42616(orf name)|uniprotkb:CG42616(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_723909.2|flybase:FBgn0261268|ensemblmetazoa:FBgn0261268(gene)|ensemblmetazoa:FBtr0302159(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007278"(pole cell fate determination)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007423"(sensory organ development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030431"(sleep)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0120177"(negative regulation of torso signaling pathway)|go:"GO:1901044"(protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-4641258|reactome:R-DME-5632684|reactome:R-DME-8932339|reactome:R-DME-8951664|reactome:R-DME-9013418|reactome:R-DME-9013422|reactome:R-DME-9706019|reactome:R-DME-983168|interpro:IPR016159(Cullin repeat-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:pwFZYlejulgX/VbVJw7NDnM2Dvs7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q09024 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-113241|uniprotkb:Q6NLN1|uniprotkb:Q7KV52|uniprotkb:Q95SU7|uniprotkb:Q9VZF7|ensemblmetazoa:FBpp0073106 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:impl2_drome(display_long)|uniprotkb:ImpL2(gene name)|psi-mi:ImpL2(display_short)|uniprotkb:CG15009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_523921.3|refseq:NP_728960.1|refseq:NP_728961.2|flybase:FBgn0001257|interpro:IPR036179|rcsb pdb:4CBP|rcsb pdb:6FEY|rcsb pdb:6FF3|ensemblmetazoa:FBgn0001257(gene)|ensemblmetazoa:FBtr0073250(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042594"(response to starvation)|go:"GO:0043559"(insulin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001261409.1|dip:DIP-20664N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:r1KXgB4BcNcGVJUgPZhlGghY+bk7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9V345 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q6NNC7 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372340 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q6nnc7_drome(display_long)|uniprotkb:CG9422(gene name)|psi-mi:CG9422(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 interpro:IPR036882|interpro:IPR002775(Alba, DNA/RNA-binding protein)|go:"GO:0003676"(nucleic acid binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:J3BdU3eOZ0VouvhDgvSdplyVlcU7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W328 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W437 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:P48598 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-198574|uniprotkb:Q95SV3|uniprotkb:Q9VSX8|uniprotkb:Q9VSX9|uniprotkb:A4V1Q6|ensemblmetazoa:FBpp0076215|ensemblmetazoa:FBpp0076217|ensemblmetazoa:FBpp0076218|ensemblmetazoa:FBpp0076219|ensemblmetazoa:FBpp0076220|ensemblmetazoa:FBpp0076221|ensemblmetazoa:FBpp0306016|ensemblmetazoa:FBpp0306017 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:if4e_drome(display_long)|uniprotkb:eIF4E1(gene name)|psi-mi:eIF4E1(display_short)|uniprotkb:Eif4e(gene name synonym)|uniprotkb:eIF-4E(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:CG4035(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_001261626.1|refseq:NP_001261627.1|refseq:NP_524829.1|refseq:NP_729480.1|refseq:NP_729481.1|refseq:NP_729482.1|refseq:NP_729483.1|refseq:NP_729484.1|refseq:NP_729485.1|flybase:FBgn0015218|dip:DIP-17448N|ensemblmetazoa:FBgn0015218(gene)|ensemblmetazoa:FBtr0076487(transcript)|ensemblmetazoa:FBtr0076489(transcript)|ensemblmetazoa:FBtr0076490(transcript)|ensemblmetazoa:FBtr0076491(transcript)|ensemblmetazoa:FBtr0076492(transcript)|ensemblmetazoa:FBtr0076493(transcript)|ensemblmetazoa:FBtr0333884(transcript)|ensemblmetazoa:FBtr0333885(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045182"(translation regulator activity)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098794"(postsynapse)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:4AXG|rcsb pdb:4UE8|rcsb pdb:4UE9|rcsb pdb:4UEA|rcsb pdb:4UEB|rcsb pdb:4UEC|rcsb pdb:5ABU|rcsb pdb:5ABV|rcsb pdb:5T47|rcsb pdb:5T48|reactome:R-DME-110523|reactome:R-DME-1169408|reactome:R-DME-156827|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-166208|reactome:R-DME-429947|reactome:R-DME-72649|reactome:R-DME-72662|reactome:R-DME-72702 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:htX4CrNeZ/TE59IjlVxQ9GeQdxk7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W3C4 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372385|uniprotkb:Q9W3C5|ensemblmetazoa:FBpp0071192 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q9w3c4_drome(display_long)|uniprotkb:Hexo2(gene name)|psi-mi:Hexo2(display_short)|uniprotkb:DmHex2(gene name synonym)|uniprotkb:Dmel\CG1787(gene name synonym)|uniprotkb:HEX 2(gene name synonym)|uniprotkb:HEX2(gene name synonym)|uniprotkb:HEXO2(gene name synonym)|uniprotkb:Dmel_CG1787(orf name)|uniprotkb:CG1787(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_525081.1|flybase:FBgn0041629|ensemblmetazoa:FBgn0041629(gene)|ensemblmetazoa:FBtr0071249(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0032504"(multicellular organism reproduction)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|reactome:R-DME-2022857|reactome:R-DME-2024101|reactome:R-DME-2160916|reactome:R-DME-6798695|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|reactome:R-DME-1660662 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:Y0JFN0U7MHuJhJaRN0pFwhQ9qs47227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9V719 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q2MGL3 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-1151669|uniprotkb:C0PUX7|ensemblmetazoa:FBpp0099986|ensemblmetazoa:FBpp0311904 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:pop7_drome(display_long)|uniprotkb:Rpp20(gene name)|psi-mi:Rpp20(display_short)|uniprotkb:CG33931(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372404|imex:IM-15821-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_001027078.1|flybase:FBgn0066304|refseq:NP_001285462.1|ensemblmetazoa:FBgn0066304(gene)|ensemblmetazoa:FBtr0091935(transcript)|ensemblmetazoa:FBtr0346040(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005634"(nucleus)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR002775(Alba, DNA/RNA-binding protein)|interpro:IPR014612(RNase P/MRP, subunit p20)|interpro:IPR036882 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:J77avS9+C6MlVcfUTbcehojViDo7227 intact-crc:D4D30060B7124DE3|rigid:B8hzexmKZ3KgkAj2t+Wmxe9F/tU false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W328 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q6NNC7 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372340 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q6nnc7_drome(display_long)|uniprotkb:CG9422(gene name)|psi-mi:CG9422(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 interpro:IPR036882|interpro:IPR002775(Alba, DNA/RNA-binding protein)|go:"GO:0003676"(nucleic acid binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:J3BdU3eOZ0VouvhDgvSdplyVlcU7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W437 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:P48598 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-198574|uniprotkb:Q95SV3|uniprotkb:Q9VSX8|uniprotkb:Q9VSX9|uniprotkb:A4V1Q6|ensemblmetazoa:FBpp0076215|ensemblmetazoa:FBpp0076217|ensemblmetazoa:FBpp0076218|ensemblmetazoa:FBpp0076219|ensemblmetazoa:FBpp0076220|ensemblmetazoa:FBpp0076221|ensemblmetazoa:FBpp0306016|ensemblmetazoa:FBpp0306017 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:if4e_drome(display_long)|uniprotkb:eIF4E1(gene name)|psi-mi:eIF4E1(display_short)|uniprotkb:Eif4e(gene name synonym)|uniprotkb:eIF-4E(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:CG4035(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_001261626.1|refseq:NP_001261627.1|refseq:NP_524829.1|refseq:NP_729480.1|refseq:NP_729481.1|refseq:NP_729482.1|refseq:NP_729483.1|refseq:NP_729484.1|refseq:NP_729485.1|flybase:FBgn0015218|dip:DIP-17448N|ensemblmetazoa:FBgn0015218(gene)|ensemblmetazoa:FBtr0076487(transcript)|ensemblmetazoa:FBtr0076489(transcript)|ensemblmetazoa:FBtr0076490(transcript)|ensemblmetazoa:FBtr0076491(transcript)|ensemblmetazoa:FBtr0076492(transcript)|ensemblmetazoa:FBtr0076493(transcript)|ensemblmetazoa:FBtr0333884(transcript)|ensemblmetazoa:FBtr0333885(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045182"(translation regulator activity)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098794"(postsynapse)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:4AXG|rcsb pdb:4UE8|rcsb pdb:4UE9|rcsb pdb:4UEA|rcsb pdb:4UEB|rcsb pdb:4UEC|rcsb pdb:5ABU|rcsb pdb:5ABV|rcsb pdb:5T47|rcsb pdb:5T48|reactome:R-DME-110523|reactome:R-DME-1169408|reactome:R-DME-156827|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-166208|reactome:R-DME-429947|reactome:R-DME-72649|reactome:R-DME-72662|reactome:R-DME-72702 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:htX4CrNeZ/TE59IjlVxQ9GeQdxk7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q8IP45 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372346|ensemblmetazoa:FBpp0291369 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q8ip45_drome(display_long)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)|uniprotkb:Cul-3(gene name synonym)|uniprotkb:Cul-3-RF(gene name synonym)|uniprotkb:"BG:DS07851.2"(gene name synonym)|uniprotkb:CUL-3(gene name synonym)|uniprotkb:CUL3(gene name synonym)|uniprotkb:Cullin3(gene name synonym)|uniprotkb:DMcul-3(gene name synonym)|uniprotkb:Dmel\CG42616(gene name synonym)|uniprotkb:br34(gene name synonym)|uniprotkb:cul-3(gene name synonym)|uniprotkb:cul3(gene name synonym)|uniprotkb:dCul-3(gene name synonym)|uniprotkb:dCul3(gene name synonym)|uniprotkb:gft(gene name synonym)|uniprotkb:guftagu(gene name synonym)|uniprotkb:"l(2)06430"(gene name synonym)|uniprotkb:"l(2)35Cd"(gene name synonym)|uniprotkb:CG11861(gene name synonym)|uniprotkb:CG31829(gene name synonym)|uniprotkb:"l(2)br34"(gene name synonym)|uniprotkb:l35Cd(gene name synonym)|uniprotkb:mds(gene name synonym)|uniprotkb:Dmel_CG42616(orf name)|uniprotkb:CG42616(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_723909.2|flybase:FBgn0261268|ensemblmetazoa:FBgn0261268(gene)|ensemblmetazoa:FBtr0302159(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007278"(pole cell fate determination)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007423"(sensory organ development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030431"(sleep)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0120177"(negative regulation of torso signaling pathway)|go:"GO:1901044"(protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-4641258|reactome:R-DME-5632684|reactome:R-DME-8932339|reactome:R-DME-8951664|reactome:R-DME-9013418|reactome:R-DME-9013422|reactome:R-DME-9706019|reactome:R-DME-983168|interpro:IPR016159(Cullin repeat-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:pwFZYlejulgX/VbVJw7NDnM2Dvs7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q2MGL3 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-1151669|uniprotkb:C0PUX7|ensemblmetazoa:FBpp0099986|ensemblmetazoa:FBpp0311904 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:pop7_drome(display_long)|uniprotkb:Rpp20(gene name)|psi-mi:Rpp20(display_short)|uniprotkb:CG33931(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_001027078.1|flybase:FBgn0066304|refseq:NP_001285462.1|ensemblmetazoa:FBgn0066304(gene)|ensemblmetazoa:FBtr0091935(transcript)|ensemblmetazoa:FBtr0346040(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005634"(nucleus)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR002775(Alba, DNA/RNA-binding protein)|interpro:IPR014612(RNase P/MRP, subunit p20)|interpro:IPR036882 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:J77avS9+C6MlVcfUTbcehojViDo7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9V719 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9W3C4 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372385|uniprotkb:Q9W3C5|ensemblmetazoa:FBpp0071192 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q9w3c4_drome(display_long)|uniprotkb:Hexo2(gene name)|psi-mi:Hexo2(display_short)|uniprotkb:DmHex2(gene name synonym)|uniprotkb:Dmel\CG1787(gene name synonym)|uniprotkb:HEX 2(gene name synonym)|uniprotkb:HEX2(gene name synonym)|uniprotkb:HEXO2(gene name synonym)|uniprotkb:Dmel_CG1787(orf name)|uniprotkb:CG1787(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_525081.1|flybase:FBgn0041629|ensemblmetazoa:FBgn0041629(gene)|ensemblmetazoa:FBtr0071249(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0032504"(multicellular organism reproduction)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|reactome:R-DME-2022857|reactome:R-DME-2024101|reactome:R-DME-2160916|reactome:R-DME-6798695|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|reactome:R-DME-1660662 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:Y0JFN0U7MHuJhJaRN0pFwhQ9qs47227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q09024 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-113241|uniprotkb:Q6NLN1|uniprotkb:Q7KV52|uniprotkb:Q95SU7|uniprotkb:Q9VZF7|ensemblmetazoa:FBpp0073106 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:impl2_drome(display_long)|uniprotkb:ImpL2(gene name)|psi-mi:ImpL2(display_short)|uniprotkb:CG15009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_523921.3|refseq:NP_728960.1|refseq:NP_728961.2|flybase:FBgn0001257|interpro:IPR036179|rcsb pdb:4CBP|rcsb pdb:6FEY|rcsb pdb:6FF3|ensemblmetazoa:FBgn0001257(gene)|ensemblmetazoa:FBtr0073250(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042594"(response to starvation)|go:"GO:0043559"(insulin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001261409.1|dip:DIP-20664N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:r1KXgB4BcNcGVJUgPZhlGghY+bk7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q86B79 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9VK45 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q95R60 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-4372372 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:q95r60_drome(display_long)|uniprotkb:CG8060(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 flybase:FBgn0034113|go:"GO:0005654"(nucleoplasm)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR002110(Ankyrin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR020683|interpro:IPR036770 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:N/jAvEaX9Gq1AiilRnkGfPNj6UE7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9XZ56 uniprotkb:Q9V345 intact:EBI-112695|ensemblmetazoa:FBpp0077213|ensemblmetazoa:FBpp0311456 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:4ebp_drome(display_long)|uniprotkb:Thor(gene name)|psi-mi:Thor(display_short)|uniprotkb:4E-binding protein Thor(gene name synonym)|uniprotkb:CG8846(orf name) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372422|imex:IM-15821-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477295.1|flybase:FBgn0261560|refseq:NP_001285588.1|ensemblmetazoa:FBgn0261560(gene)|ensemblmetazoa:FBtr0077524(transcript)|ensemblmetazoa:FBtr0345289(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009617"(response to bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042594"(response to starvation)|go:"GO:0045087"(innate immune response)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR008606(Eukaryotic translation initiation factor 4E binding)|rcsb pdb:4UE8|reactome:R-DME-110523|reactome:R-DME-166208|reactome:R-DME-72662 ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:BSs5we6e7D1aDFfyiDA0uCtui0Q7227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 intact-crc:C92EE2EB8518E63F|rigid:D+Dp4rMPUMttnEYL4IyG3yslWAk false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q95V55 uniprotkb:P29310 intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372441|imex:IM-15821-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:AF81734313D84B1B|rigid:4sIwZs8YW/bqX+BeBCUk/fTQtcw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q95V55 uniprotkb:P92177 intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372441|imex:IM-15821-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:AF81734313D84B1B|rigid:4sIwZs8YW/bqX+BeBCUk/fTQtcw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9N2M8 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-97141|uniprotkb:Q24480|uniprotkb:Q95SY2|uniprotkb:Q9VA84|ensemblmetazoa:FBpp0084985 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:hdc_drome(display_long)|uniprotkb:CG15532(orf name)|uniprotkb:hdc(gene name)|psi-mi:hdc(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372447|imex:IM-15821-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N refseq:NP_524592.2|refseq:NP_788768.1|flybase:FBgn0010113|refseq:NP_001263103.1|ensemblmetazoa:FBgn0010113(gene)|ensemblmetazoa:FBtr0085621(transcript)|go:"GO:0002165"(instar larval or pupal development)|go:"GO:0005737"(cytoplasm)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0016246"(RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:1904799"(regulation of neuron remodeling)|interpro:IPR026066|interpro:IPR031947 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:xhXUqf4+SFn4oi5WiEiUJZUbNxA7227 intact-crc:4C18E84A00301561|rigid:Wxv8yQmjlr+PJnDoB18+p2SDmJI false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9V719 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372447|imex:IM-15821-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:4C18E84A00301561|rigid:Wxv8yQmjlr+PJnDoB18+p2SDmJI false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9VK45 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372447|imex:IM-15821-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:4C18E84A00301561|rigid:Wxv8yQmjlr+PJnDoB18+p2SDmJI false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9W437 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372447|imex:IM-15821-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:4C18E84A00301561|rigid:Wxv8yQmjlr+PJnDoB18+p2SDmJI false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9W328 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372456|imex:IM-15821-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:D5913227FBFE3E79|rigid:6scncuKjixyc1K9w3tN2EFA7KOs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9V719 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372456|imex:IM-15821-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:D5913227FBFE3E79|rigid:6scncuKjixyc1K9w3tN2EFA7KOs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9N2M8 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-97141|uniprotkb:Q24480|uniprotkb:Q95SY2|uniprotkb:Q9VA84|ensemblmetazoa:FBpp0084985 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:hdc_drome(display_long)|uniprotkb:CG15532(orf name)|uniprotkb:hdc(gene name)|psi-mi:hdc(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372456|imex:IM-15821-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N refseq:NP_524592.2|refseq:NP_788768.1|flybase:FBgn0010113|refseq:NP_001263103.1|ensemblmetazoa:FBgn0010113(gene)|ensemblmetazoa:FBtr0085621(transcript)|go:"GO:0002165"(instar larval or pupal development)|go:"GO:0005737"(cytoplasm)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0016246"(RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:1904799"(regulation of neuron remodeling)|interpro:IPR026066|interpro:IPR031947 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:xhXUqf4+SFn4oi5WiEiUJZUbNxA7227 intact-crc:D5913227FBFE3E79|rigid:6scncuKjixyc1K9w3tN2EFA7KOs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9W437 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372456|imex:IM-15821-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:D5913227FBFE3E79|rigid:6scncuKjixyc1K9w3tN2EFA7KOs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86B79 uniprotkb:Q9VK45 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372456|imex:IM-15821-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:D5913227FBFE3E79|rigid:6scncuKjixyc1K9w3tN2EFA7KOs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VHL2 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-102936|ensemblmetazoa:FBpp0081401 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vhl2_drome(display_long)|uniprotkb:CG8351(orf name)|uniprotkb:Cct7(gene name synonym)|uniprotkb:Dmel\CG8351(gene name synonym)|uniprotkb:Q9VHL2_DROME(gene name synonym)|uniprotkb:TCP1eta(gene name synonym)|uniprotkb:TCPeta(gene name synonym)|uniprotkb:Tcp-1-eta1(gene name synonym)|uniprotkb:tcp-1eta(gene name synonym)|uniprotkb:tcp1eta(gene name synonym)|uniprotkb:Dmel_CG8351(orf name)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:Tcp-1eta(gene name synonym)|uniprotkb:T-cp1eta(gene name synonym)|uniprotkb:TCP1-eta(gene name synonym)|uniprotkb:CCT-eta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_649835.1|flybase:FBgn0037632|ensemblmetazoa:FBgn0037632(gene)|ensemblmetazoa:FBtr0081918(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|reactome:R-DME-390471|reactome:R-DME-6814122|reactome:R-DME-9013418|reactome:R-DME-9013422 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:wRbc8Yrczcc64aX0+ui6yrLLAKw7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VXQ5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-158907|ensemblmetazoa:FBpp0073902 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vxq5_drome(display_long)|uniprotkb:TCP1-zeta(gene name synonym)|uniprotkb:CCT6(gene name)|psi-mi:CCT6(display_short)|uniprotkb:Tcp-1zeta(gene name synonym)|uniprotkb:"l(1)G0022"(gene name synonym)|uniprotkb:Dmel\CG8231(gene name synonym)|uniprotkb:"L(1)g0022"(gene name synonym)|uniprotkb:Q9VXQ5_DROME(gene name synonym)|uniprotkb:Rcd3(gene name synonym)|uniprotkb:TCP-1-zeta(gene name synonym)|uniprotkb:TCP-1zeta(gene name synonym)|uniprotkb:TCP1zeta(gene name synonym)|uniprotkb:TCPzeta(gene name synonym)|uniprotkb:Tcp-1-zeta(gene name synonym)|uniprotkb:"l(1)G0027"(gene name synonym)|uniprotkb:"l(1)G0057"(gene name synonym)|uniprotkb:Dmel_CG8231(orf name)|uniprotkb:CG8231(orf name)|uniprotkb:Cct6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0027329(gene)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|reactome:R-DME-390471|reactome:R-DME-6814122|reactome:R-DME-9013418|ensemblmetazoa:FBtr0074086(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0007099"(centriole replication)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|refseq:NP_573066.1|flybase:FBgn0027329 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:yzXbett6ZsMpOyV/0JqLwQQWYNc7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VTE5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-112583|uniprotkb:C6SV13|ensemblmetazoa:FBpp0075967|ensemblmetazoa:FBpp0304954 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:pfd2_drome(display_long)|uniprotkb:Pfdn2(gene name)|psi-mi:Pfdn2(display_short)|uniprotkb:"l(3)01239"(gene name synonym)|uniprotkb:CG6302(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_729659.1|flybase:FBgn0010741|refseq:NP_001261696.1|dip:DIP-22191N|ensemblmetazoa:FBgn0010741(gene)|ensemblmetazoa:FBtr0076238(transcript)|ensemblmetazoa:FBtr0332708(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:ccPPMbwX2DWNB1xHVoFjzMiyJ/o7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:A1Z813 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-183080|ensemblmetazoa:FBpp0087536|ensemblmetazoa:FBpp0308496 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:a1z813_drome(display_long)|uniprotkb:Sec24AB(gene name)|psi-mi:Sec24AB(display_short)|uniprotkb:sec24(gene name synonym)|uniprotkb:Dmel_CG1472(orf name)|uniprotkb:Dmel\CG1472(gene name synonym)|uniprotkb:Hau(gene name synonym)|uniprotkb:SEC24(gene name synonym)|uniprotkb:Sec24(gene name synonym)|uniprotkb:CG1472(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_610531.1|flybase:FBgn0033460|refseq:NP_001286257.1|ensemblmetazoa:FBgn0033460(gene)|ensemblmetazoa:FBtr0088451(transcript)|ensemblmetazoa:FBtr0339406(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|reactome:R-DME-204005 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:+6xW4WGOA4mwXAa/3A5XkHMlRRE7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VPN5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-118660|ensemblmetazoa:FBpp0077790 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vpn5_drome(display_long)|uniprotkb:CG2720(orf name)|uniprotkb:Stip1(gene name)|psi-mi:Stip1(display_short)|uniprotkb:Dmel\CG2720(gene name synonym)|uniprotkb:"EP(2)0418"(gene name synonym)|uniprotkb:HOP(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Sti1(gene name synonym)|uniprotkb:dHop(gene name synonym)|uniprotkb:dSTI1(gene name synonym)|uniprotkb:dhop(gene name synonym)|uniprotkb:dmSTI1(gene name synonym)|uniprotkb:hop(gene name synonym)|uniprotkb:"l(2)k00616"(gene name synonym)|uniprotkb:Dmel_CG2720(orf name)|uniprotkb:dSTIP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_477354.1|flybase:FBgn0024352|ensemblmetazoa:FBgn0024352(gene)|ensemblmetazoa:FBtr0078131(transcript)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR041243|reactome:R-DME-3371497 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:SAXsZrlV0UUNuTCiSJK6QzxUz2E7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VNF8 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-158145|ensemblmetazoa:FBpp0078359|ensemblmetazoa:FBpp0078360|ensemblmetazoa:FBpp0303346|ensemblmetazoa:FBpp0308424 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vnf8_drome(display_long)|uniprotkb:Sec23(gene name)|psi-mi:Sec23(display_short)|uniprotkb:sec23(gene name synonym)|uniprotkb:Dmel_CG1250(orf name)|uniprotkb:CG1250(orf name)|uniprotkb:COPII(gene name synonym)|uniprotkb:Dmel\CG1250(gene name synonym)|uniprotkb:SEC23(gene name synonym)|uniprotkb:Sec23A(gene name synonym)|uniprotkb:Sec23p(gene name synonym)|uniprotkb:dSec23(gene name synonym)|uniprotkb:dSec23p(gene name synonym)|uniprotkb:dar2(gene name synonym)|uniprotkb:dsec23(gene name synonym)|uniprotkb:dsec23p(gene name synonym)|uniprotkb:hau(gene name synonym)|uniprotkb:Hau(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0262125(gene)|ensemblmetazoa:FBtr0078710(transcript)|ensemblmetazoa:FBtr0078711(transcript)|ensemblmetazoa:FBtr0330314(transcript)|ensemblmetazoa:FBtr0339320(transcript)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008363"(larval chitin-based cuticle development)|go:"GO:0016203"(muscle attachment)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048081"(positive regulation of cuticle pigmentation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|refseq:NP_001287184.1|refseq:NP_730978.1|refseq:NP_730979.1|flybase:FBgn0262125|refseq:NP_001262294.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:5nuKVQRFeQecOtrP9R30uQdobWw7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VK45 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9W437 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372466|imex:IM-15821-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:B2809190DDBE8D60|rigid:WNJ22BDLA68WbY1YkSNn35S1wKE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VXQ5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-158907|ensemblmetazoa:FBpp0073902 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vxq5_drome(display_long)|uniprotkb:TCP1-zeta(gene name synonym)|uniprotkb:CCT6(gene name)|psi-mi:CCT6(display_short)|uniprotkb:Tcp-1zeta(gene name synonym)|uniprotkb:"l(1)G0022"(gene name synonym)|uniprotkb:Dmel\CG8231(gene name synonym)|uniprotkb:"L(1)g0022"(gene name synonym)|uniprotkb:Q9VXQ5_DROME(gene name synonym)|uniprotkb:Rcd3(gene name synonym)|uniprotkb:TCP-1-zeta(gene name synonym)|uniprotkb:TCP-1zeta(gene name synonym)|uniprotkb:TCP1zeta(gene name synonym)|uniprotkb:TCPzeta(gene name synonym)|uniprotkb:Tcp-1-zeta(gene name synonym)|uniprotkb:"l(1)G0027"(gene name synonym)|uniprotkb:"l(1)G0057"(gene name synonym)|uniprotkb:Dmel_CG8231(orf name)|uniprotkb:CG8231(orf name)|uniprotkb:Cct6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0027329(gene)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|reactome:R-DME-390471|reactome:R-DME-6814122|reactome:R-DME-9013418|ensemblmetazoa:FBtr0074086(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0007099"(centriole replication)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|refseq:NP_573066.1|flybase:FBgn0027329 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:yzXbett6ZsMpOyV/0JqLwQQWYNc7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:A1Z813 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-183080|ensemblmetazoa:FBpp0087536|ensemblmetazoa:FBpp0308496 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:a1z813_drome(display_long)|uniprotkb:Sec24AB(gene name)|psi-mi:Sec24AB(display_short)|uniprotkb:sec24(gene name synonym)|uniprotkb:Dmel_CG1472(orf name)|uniprotkb:Dmel\CG1472(gene name synonym)|uniprotkb:Hau(gene name synonym)|uniprotkb:SEC24(gene name synonym)|uniprotkb:Sec24(gene name synonym)|uniprotkb:CG1472(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_610531.1|flybase:FBgn0033460|refseq:NP_001286257.1|ensemblmetazoa:FBgn0033460(gene)|ensemblmetazoa:FBtr0088451(transcript)|ensemblmetazoa:FBtr0339406(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|reactome:R-DME-204005 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:+6xW4WGOA4mwXAa/3A5XkHMlRRE7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VPN5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-118660|ensemblmetazoa:FBpp0077790 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vpn5_drome(display_long)|uniprotkb:CG2720(orf name)|uniprotkb:Stip1(gene name)|psi-mi:Stip1(display_short)|uniprotkb:Dmel\CG2720(gene name synonym)|uniprotkb:"EP(2)0418"(gene name synonym)|uniprotkb:HOP(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Sti1(gene name synonym)|uniprotkb:dHop(gene name synonym)|uniprotkb:dSTI1(gene name synonym)|uniprotkb:dhop(gene name synonym)|uniprotkb:dmSTI1(gene name synonym)|uniprotkb:hop(gene name synonym)|uniprotkb:"l(2)k00616"(gene name synonym)|uniprotkb:Dmel_CG2720(orf name)|uniprotkb:dSTIP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_477354.1|flybase:FBgn0024352|ensemblmetazoa:FBgn0024352(gene)|ensemblmetazoa:FBtr0078131(transcript)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR041243|reactome:R-DME-3371497 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:SAXsZrlV0UUNuTCiSJK6QzxUz2E7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q7JXA2 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VHL2 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-102936|ensemblmetazoa:FBpp0081401 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vhl2_drome(display_long)|uniprotkb:CG8351(orf name)|uniprotkb:Cct7(gene name synonym)|uniprotkb:Dmel\CG8351(gene name synonym)|uniprotkb:Q9VHL2_DROME(gene name synonym)|uniprotkb:TCP1eta(gene name synonym)|uniprotkb:TCPeta(gene name synonym)|uniprotkb:Tcp-1-eta1(gene name synonym)|uniprotkb:tcp-1eta(gene name synonym)|uniprotkb:tcp1eta(gene name synonym)|uniprotkb:Dmel_CG8351(orf name)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:Tcp-1eta(gene name synonym)|uniprotkb:T-cp1eta(gene name synonym)|uniprotkb:TCP1-eta(gene name synonym)|uniprotkb:CCT-eta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_649835.1|flybase:FBgn0037632|ensemblmetazoa:FBgn0037632(gene)|ensemblmetazoa:FBtr0081918(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|reactome:R-DME-390471|reactome:R-DME-6814122|reactome:R-DME-9013418|reactome:R-DME-9013422 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:wRbc8Yrczcc64aX0+ui6yrLLAKw7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VTE5 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-112583|uniprotkb:C6SV13|ensemblmetazoa:FBpp0075967|ensemblmetazoa:FBpp0304954 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:pfd2_drome(display_long)|uniprotkb:Pfdn2(gene name)|psi-mi:Pfdn2(display_short)|uniprotkb:"l(3)01239"(gene name synonym)|uniprotkb:CG6302(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 refseq:NP_729659.1|flybase:FBgn0010741|refseq:NP_001261696.1|dip:DIP-22191N|ensemblmetazoa:FBgn0010741(gene)|ensemblmetazoa:FBtr0076238(transcript)|ensemblmetazoa:FBtr0332708(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:ccPPMbwX2DWNB1xHVoFjzMiyJ/o7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VNF8 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-158145|ensemblmetazoa:FBpp0078359|ensemblmetazoa:FBpp0078360|ensemblmetazoa:FBpp0303346|ensemblmetazoa:FBpp0308424 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9vnf8_drome(display_long)|uniprotkb:Sec23(gene name)|psi-mi:Sec23(display_short)|uniprotkb:sec23(gene name synonym)|uniprotkb:Dmel_CG1250(orf name)|uniprotkb:CG1250(orf name)|uniprotkb:COPII(gene name synonym)|uniprotkb:Dmel\CG1250(gene name synonym)|uniprotkb:SEC23(gene name synonym)|uniprotkb:Sec23A(gene name synonym)|uniprotkb:Sec23p(gene name synonym)|uniprotkb:dSec23(gene name synonym)|uniprotkb:dSec23p(gene name synonym)|uniprotkb:dar2(gene name synonym)|uniprotkb:dsec23(gene name synonym)|uniprotkb:dsec23p(gene name synonym)|uniprotkb:hau(gene name synonym)|uniprotkb:Hau(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0262125(gene)|ensemblmetazoa:FBtr0078710(transcript)|ensemblmetazoa:FBtr0078711(transcript)|ensemblmetazoa:FBtr0330314(transcript)|ensemblmetazoa:FBtr0339320(transcript)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008363"(larval chitin-based cuticle development)|go:"GO:0016203"(muscle attachment)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048081"(positive regulation of cuticle pigmentation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR037364|interpro:IPR037550|refseq:NP_001287184.1|refseq:NP_730978.1|refseq:NP_730979.1|flybase:FBgn0262125|refseq:NP_001262294.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:5nuKVQRFeQecOtrP9R30uQdobWw7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9W437 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W328 uniprotkb:Q9VK45 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372479|imex:IM-15821-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:72384FE924C4D964|rigid:qNMZ8c3id6f6jZYwalX9H/1OCBA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9VWJ6 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:O77237 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-92779|ensemblmetazoa:FBpp0083913|ensemblmetazoa:FBpp0111820 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:peli_drome(display_long)|uniprotkb:Pli(gene name)|psi-mi:Pli(display_short)|uniprotkb:CG5212(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_001097890.1|refseq:NP_524466.1|flybase:FBgn0025574|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|interpro:IPR006800(Pellino)|reactome:R-DME-9020702|go:"GO:0061630"(ubiquitin protein ligase activity)|ensemblmetazoa:FBgn0025574(gene)|ensemblmetazoa:FBtr0084527(transcript)|ensemblmetazoa:FBtr0112907(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045752"(positive regulation of Toll signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:f6A3mbxIheYPOEzfh7GdL3o+m487227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W437 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9VK45 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W437 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W328 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q7JXA2 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372643|imex:IM-15821-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:7C5EF77F6ECA2C08|rigid:a9Y1tp/YaJUxXdiYOq8H0/tryc8 false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:O77237 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-92779|ensemblmetazoa:FBpp0083913|ensemblmetazoa:FBpp0111820 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:peli_drome(display_long)|uniprotkb:Pli(gene name)|psi-mi:Pli(display_short)|uniprotkb:CG5212(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_001097890.1|refseq:NP_524466.1|flybase:FBgn0025574|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|interpro:IPR006800(Pellino)|reactome:R-DME-9020702|go:"GO:0061630"(ubiquitin protein ligase activity)|ensemblmetazoa:FBgn0025574(gene)|ensemblmetazoa:FBtr0084527(transcript)|ensemblmetazoa:FBtr0112907(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045752"(positive regulation of Toll signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:f6A3mbxIheYPOEzfh7GdL3o+m487227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q7KV90 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-4372656|ensemblmetazoa:FBpp0089310|ensemblmetazoa:FBpp0305557 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q7kv90_drome(display_long)|uniprotkb:msn(gene name)|psi-mi:msn(display_short)|uniprotkb:6286(gene name synonym)|uniprotkb:DMSN(gene name synonym)|uniprotkb:Dmel\CG16973(gene name synonym)|uniprotkb:HGK(gene name synonym)|uniprotkb:JNKKKK(gene name synonym)|uniprotkb:MESR5(gene name synonym)|uniprotkb:MSN(gene name synonym)|uniprotkb:Msn(gene name synonym)|uniprotkb:NIK(gene name synonym)|uniprotkb:Nik(gene name synonym)|uniprotkb:"l(3)03349"(gene name synonym)|uniprotkb:"l(3)06946"(gene name synonym)|uniprotkb:"l(3)6286"(gene name synonym)|uniprotkb:"l(3)j1E2"(gene name synonym)|uniprotkb:msm(gene name synonym)|uniprotkb:Dmel_CG16973(orf name)|uniprotkb:CG16973(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_995974.1|flybase:FBgn0010909|refseq:NP_001261333.1|ensemblmetazoa:FBgn0010909(gene)|ensemblmetazoa:FBtr0072957(transcript)|ensemblmetazoa:FBtr0333365(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001748"(insect visual primordium development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007254"(JNK cascade)|go:"GO:0007391"(dorsal closure)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0046529"(imaginal disc fusion, thorax closure)|go:"GO:0048812"(neuron projection morphogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0009611"(response to wounding)|go:"GO:0016476"(regulation of embryonic cell shape)|interpro:IPR011009(Protein kinase-like)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042656"(JUN kinase kinase kinase kinase activity)|go:"GO:0043408"(regulation of MAPK cascade) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:Iv1Vkd3HBTQlz7khpmCdypEkJk07227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:P92177 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W437 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9VWJ6 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W437 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9W328 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9V719 uniprotkb:Q9VK45 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372686|imex:IM-15821-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:BBF9DEC905277110|rigid:ePwURka9sGTAFeGzGcuCGxqf1FE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9W328 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V3K3 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-192924|ensemblmetazoa:FBpp0074756|ensemblmetazoa:FBpp0304236|ensemblmetazoa:FBpp0311247 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:ruvb2_drome(display_long)|uniprotkb:rept(gene name)|psi-mi:rept(display_short)|uniprotkb:CG9750(orf name)|uniprotkb:Dreptin(gene name synonym)|uniprotkb:Reptin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_524156.1|flybase:FBgn0040075|refseq:NP_001287113.1|refseq:NP_001262040.1|ensemblmetazoa:FBgn0040075(gene)|ensemblmetazoa:FBtr0074988(transcript)|ensemblmetazoa:FBtr0331852(transcript)|ensemblmetazoa:FBtr0344993(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:OTelAlg6zQwi3chtx0C/iDKL/607227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9VH07 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-234957|intact:EBI-867973|uniprotkb:Q9VH06|uniprotkb:Q9NH53|intact:EBI-234969|ensemblmetazoa:FBpp0081704 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:ruvb1_drome(display_long)|uniprotkb:pont(gene name)|psi-mi:pont(display_short)|uniprotkb:CG4003(orf name)|uniprotkb:Pontin(gene name synonym)|uniprotkb:Dpontin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_652608.1|flybase:FBgn0040078|ensemblmetazoa:FBgn0040078(gene)|ensemblmetazoa:FBtr0082226(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035060"(brahma complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051301"(cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9VH07|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-5696394 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:myRpAnG8tKBHMEnKg+JkpIVkTKg7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9W437 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q8IN05 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-4372700|ensemblmetazoa:FBpp0288790 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q8in05_drome(display_long)|uniprotkb:lqfR(gene name)|psi-mi:lqfR(display_short)|uniprotkb:epsin-like(gene name synonym)|uniprotkb:CG31170(gene name synonym)|uniprotkb:CG31285(gene name synonym)|uniprotkb:CG13853(gene name synonym)|uniprotkb:CG13854(gene name synonym)|uniprotkb:Dmel\CG42250(gene name synonym)|uniprotkb:Epsin(gene name synonym)|uniprotkb:LqfR(gene name synonym)|uniprotkb:Lqfr(gene name synonym)|uniprotkb:Tel2(gene name synonym)|uniprotkb:XII-10(gene name synonym)|uniprotkb:dTel2(gene name synonym)|uniprotkb:epsin(gene name synonym)|uniprotkb:epsin02(gene name synonym)|uniprotkb:epsinR(gene name synonym)|uniprotkb:"l(3)03685"(gene name synonym)|uniprotkb:"l(3)A9"(gene name synonym)|uniprotkb:"l(3)SG62"(gene name synonym)|uniprotkb:"l(3)XII-10"(gene name synonym)|uniprotkb:"l(3)dsl-9"(gene name synonym)|uniprotkb:Dmel_CG42250(orf name)|uniprotkb:"l(3)dsl9"(gene name synonym)|uniprotkb:CG42250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_732736.2|flybase:FBgn0261279|ensemblmetazoa:FBgn0261279(gene)|ensemblmetazoa:FBtr0299516(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR030544|interpro:IPR038528|reactome:R-DME-432722|go:"GO:0006897"(endocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048477"(oogenesis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0098793"(presynapse) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:HfiIkD36Hie9Gv1Bp4YG1cMMaxI7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V719 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9VH80 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V3E9 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-100795|ensemblmetazoa:FBpp0072164 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9v3e9_drome(display_long)|uniprotkb:spag(gene name)|psi-mi:spag(display_short)|uniprotkb:Spag(gene name synonym)|uniprotkb:spag-RA(gene name synonym)|uniprotkb:Dmel\CG13570(gene name synonym)|uniprotkb:SPAG(gene name synonym)|uniprotkb:"l(2)k12101"(gene name synonym)|uniprotkb:Rpap3(gene name synonym)|uniprotkb:spagh(gene name synonym)|uniprotkb:CG13570(orf name)|uniprotkb:Dmel_CG13570(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372728|imex:IM-15821-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_524664.1|flybase:FBgn0015544|ensemblmetazoa:FBgn0015544(gene)|ensemblmetazoa:FBtr0072256(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:Fwtwtr5edPft4RwbhMCcfSbVrRk7227 intact-crc:FAA7D666306B98CF|rigid:BjA3iGX7MK6dJkIRGH3OHQUw5AE false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9W328 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9VH07 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-234957|intact:EBI-867973|uniprotkb:Q9VH06|uniprotkb:Q9NH53|intact:EBI-234969|ensemblmetazoa:FBpp0081704 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:ruvb1_drome(display_long)|uniprotkb:pont(gene name)|psi-mi:pont(display_short)|uniprotkb:CG4003(orf name)|uniprotkb:Pontin(gene name synonym)|uniprotkb:Dpontin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_652608.1|flybase:FBgn0040078|ensemblmetazoa:FBgn0040078(gene)|ensemblmetazoa:FBtr0082226(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035060"(brahma complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051301"(cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9VH07|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-5696394 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:myRpAnG8tKBHMEnKg+JkpIVkTKg7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9VH80 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V3K3 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-192924|ensemblmetazoa:FBpp0074756|ensemblmetazoa:FBpp0304236|ensemblmetazoa:FBpp0311247 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:ruvb2_drome(display_long)|uniprotkb:rept(gene name)|psi-mi:rept(display_short)|uniprotkb:CG9750(orf name)|uniprotkb:Dreptin(gene name synonym)|uniprotkb:Reptin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_524156.1|flybase:FBgn0040075|refseq:NP_001287113.1|refseq:NP_001262040.1|ensemblmetazoa:FBgn0040075(gene)|ensemblmetazoa:FBtr0074988(transcript)|ensemblmetazoa:FBtr0331852(transcript)|ensemblmetazoa:FBtr0344993(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:OTelAlg6zQwi3chtx0C/iDKL/607227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V3E9 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-100795|ensemblmetazoa:FBpp0072164 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9v3e9_drome(display_long)|uniprotkb:spag(gene name)|psi-mi:spag(display_short)|uniprotkb:Spag(gene name synonym)|uniprotkb:spag-RA(gene name synonym)|uniprotkb:Dmel\CG13570(gene name synonym)|uniprotkb:SPAG(gene name synonym)|uniprotkb:"l(2)k12101"(gene name synonym)|uniprotkb:Rpap3(gene name synonym)|uniprotkb:spagh(gene name synonym)|uniprotkb:CG13570(orf name)|uniprotkb:Dmel_CG13570(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_524664.1|flybase:FBgn0015544|ensemblmetazoa:FBgn0015544(gene)|ensemblmetazoa:FBtr0072256(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:Fwtwtr5edPft4RwbhMCcfSbVrRk7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9V719 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9W437 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q9W437 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q7JXA2 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VK45 uniprotkb:Q8IN05 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 intact:EBI-4372700|ensemblmetazoa:FBpp0288790 psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:q8in05_drome(display_long)|uniprotkb:lqfR(gene name)|psi-mi:lqfR(display_short)|uniprotkb:epsin-like(gene name synonym)|uniprotkb:CG31170(gene name synonym)|uniprotkb:CG31285(gene name synonym)|uniprotkb:CG13853(gene name synonym)|uniprotkb:CG13854(gene name synonym)|uniprotkb:Dmel\CG42250(gene name synonym)|uniprotkb:Epsin(gene name synonym)|uniprotkb:LqfR(gene name synonym)|uniprotkb:Lqfr(gene name synonym)|uniprotkb:Tel2(gene name synonym)|uniprotkb:XII-10(gene name synonym)|uniprotkb:dTel2(gene name synonym)|uniprotkb:epsin(gene name synonym)|uniprotkb:epsin02(gene name synonym)|uniprotkb:epsinR(gene name synonym)|uniprotkb:"l(3)03685"(gene name synonym)|uniprotkb:"l(3)A9"(gene name synonym)|uniprotkb:"l(3)SG62"(gene name synonym)|uniprotkb:"l(3)XII-10"(gene name synonym)|uniprotkb:"l(3)dsl-9"(gene name synonym)|uniprotkb:Dmel_CG42250(orf name)|uniprotkb:"l(3)dsl9"(gene name synonym)|uniprotkb:CG42250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372742|imex:IM-15821-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 refseq:NP_732736.2|flybase:FBgn0261279|ensemblmetazoa:FBgn0261279(gene)|ensemblmetazoa:FBtr0299516(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR030544|interpro:IPR038528|reactome:R-DME-432722|go:"GO:0006897"(endocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048477"(oogenesis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0098793"(presynapse) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 rogid:HfiIkD36Hie9Gv1Bp4YG1cMMaxI7227 intact-crc:B78313D995CBDFB5|rigid:TL5nQ0tM9btro2/dVSBUJgLRXlw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9VK45 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372768|imex:IM-15821-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:92FF96309FD75A2F|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:P92177 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372768|imex:IM-15821-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:92FF96309FD75A2F|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9W328 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372768|imex:IM-15821-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:92FF96309FD75A2F|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9V719 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372768|imex:IM-15821-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:92FF96309FD75A2F|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9V719 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-2507904|ensemblmetazoa:FBpp0086616|uniprotkb:Q53YG4 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:sin1_drome(display_long)|uniprotkb:CG10105(orf name)|uniprotkb:Sin1(gene name)|psi-mi:Sin1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372758|imex:IM-15821-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 ensemblmetazoa:FBgn0033935(gene)|ensemblmetazoa:FBtr0087487(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920|mint:Q9V719|refseq:NP_610963.1|flybase:FBgn0033935 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:If/on33gBbkR+9jDTl7nJYyQHAA7227 intact-crc:9ABB5074F6F6115C|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:P92177 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372758|imex:IM-15821-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:9ABB5074F6F6115C|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9W328 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372758|imex:IM-15821-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:9ABB5074F6F6115C|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VWJ6 uniprotkb:Q9VK45 intact:EBI-3410278|ensemblmetazoa:FBpp0074458 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:q9vwj6_drome(display_long)|uniprotkb:RICTOR(gene name synonym)|uniprotkb:CG8002(orf name)|uniprotkb:rictor(gene name)|psi-mi:rictor(display_short)|uniprotkb:rictor-RA(gene name synonym)|uniprotkb:Dmel_CG8002(orf name)|uniprotkb:8002(gene name synonym)|uniprotkb:Dmel\CG8002(gene name synonym)|uniprotkb:Rictor(gene name synonym)|uniprotkb:dRic(gene name synonym)|uniprotkb:dRictor(gene name synonym)|uniprotkb:dRICTOR(gene name synonym) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372758|imex:IM-15821-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573371.1|flybase:FBgn0031006|ensemblmetazoa:FBgn0031006(gene)|ensemblmetazoa:FBtr0074689(transcript)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-DME-1257604|reactome:R-DME-389357|reactome:R-DME-5218920 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:abZsQhB9/Xxt9pt/A9PowjLdT3Q7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:9ABB5074F6F6115C|rigid:b9bpiihjdfYapA1sEMbzQYajbJw false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q24311 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-136038|uniprotkb:A4UZ78|ensemblmetazoa:FBpp0087921|ensemblmetazoa:FBpp0087922|ensemblmetazoa:FBpp0087923|ensemblmetazoa:FBpp0087924|uniprotkb:Q0E9G0|uniprotkb:Q9V312 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:cul1_drome(display_long)|uniprotkb:Cul1(gene name)|psi-mi:Cul1(display_short)|uniprotkb:Lin-19 homolog protein(gene name synonym)|uniprotkb:cul-1(gene name synonym)|uniprotkb:lin19(gene name synonym)|uniprotkb:CG1877(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_523655.1|refseq:NP_724621.1|refseq:NP_724622.1|refseq:NP_724623.1|flybase:FBgn0015509|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904801"(positive regulation of neuron remodeling)|ensemblmetazoa:FBgn0015509(gene)|ensemblmetazoa:FBtr0088845(transcript)|ensemblmetazoa:FBtr0088846(transcript)|ensemblmetazoa:FBtr0088847(transcript)|ensemblmetazoa:FBtr0088848(transcript)|go:"GO:0002785"(negative regulation of antimicrobial peptide production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q24311|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-209360|reactome:R-DME-209461|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-68949|reactome:R-DME-69231|reactome:R-DME-8854050|reactome:R-DME-8939902|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-917937|reactome:R-DME-983168|dip:DIP-19461N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:uik6AV9MpfMBKBZoYZSxvCl5bTc7227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:P91634 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q09024 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-113241|uniprotkb:Q6NLN1|uniprotkb:Q7KV52|uniprotkb:Q95SU7|uniprotkb:Q9VZF7|ensemblmetazoa:FBpp0073106 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:impl2_drome(display_long)|uniprotkb:ImpL2(gene name)|psi-mi:ImpL2(display_short)|uniprotkb:CG15009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_523921.3|refseq:NP_728960.1|refseq:NP_728961.2|flybase:FBgn0001257|interpro:IPR036179|rcsb pdb:4CBP|rcsb pdb:6FEY|rcsb pdb:6FF3|ensemblmetazoa:FBgn0001257(gene)|ensemblmetazoa:FBtr0073250(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042594"(response to starvation)|go:"GO:0043559"(insulin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001261409.1|dip:DIP-20664N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:r1KXgB4BcNcGVJUgPZhlGghY+bk7227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q9VT01 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-89020|ensemblmetazoa:FBpp0076199 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:q9vt01_drome(display_long)|uniprotkb:Dmel_CG3428(orf name)|uniprotkb:pall(gene name)|psi-mi:pall(display_short)|uniprotkb:pall-RA(gene name synonym)|uniprotkb:CG3428(orf name)|uniprotkb:Dmel\CG3428(gene name synonym)|uniprotkb:FBXO1(gene name synonym)|uniprotkb:PALL(gene name synonym)|uniprotkb:Pall(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 ensemblmetazoa:FBgn0036005(gene)|ensemblmetazoa:FBtr0076471(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR039719|refseq:NP_648325.2|flybase:FBgn0036005 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:WXwSewe42Cv/KkRSp3LSdLgAvJQ7227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q8IPG1 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-3408063|ensemblmetazoa:FBpp0079245|ensemblmetazoa:FBpp0089341|ensemblmetazoa:FBpp0292228 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:q8ipg1_drome(display_long)|uniprotkb:8222(gene name synonym)|uniprotkb:CT24332(gene name synonym)|uniprotkb:DmVEGFR(gene name synonym)|uniprotkb:Dmel\CG8222(gene name synonym)|uniprotkb:PVR(gene name synonym)|uniprotkb:VEGFR(gene name synonym)|uniprotkb:VEGFR-A(gene name synonym)|uniprotkb:VGR1(gene name synonym)|uniprotkb:Vegf(gene name synonym)|uniprotkb:Vegfr(gene name synonym)|uniprotkb:Vegfr-b(gene name synonym)|uniprotkb:Vegfr-c(gene name synonym)|uniprotkb:Vgr1(gene name synonym)|uniprotkb:pvr(gene name synonym)|uniprotkb:stai(gene name synonym)|uniprotkb:vgr1(gene name synonym)|uniprotkb:Dmel_CG8222(orf name)|uniprotkb:Pvr(gene name)|psi-mi:Pvr(display_short)|uniprotkb:PvR(gene name synonym)|uniprotkb:CG8222(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001188721.1|refseq:NP_723365.1|refseq:NP_995649.1|flybase:FBgn0032006|ensemblmetazoa:FBgn0032006(gene)|ensemblmetazoa:FBtr0079626(transcript)|ensemblmetazoa:FBtr0079628(transcript)|ensemblmetazoa:FBtr0303109(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030097"(hemopoiesis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:BvyysdOTXXxcNCzX4N83nZJ97HA7227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:O77430 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-180180|intact:EBI-1628435|ensemblmetazoa:FBpp0070118|ensemblmetazoa:FBpp0070119|ensemblmetazoa:FBpp0070120|ensemblmetazoa:FBpp0070121|ensemblmetazoa:FBpp0070122|ensemblmetazoa:FBpp0070123|ensemblmetazoa:FBpp0070124|ensemblmetazoa:FBpp0099971|ensemblmetazoa:FBpp0311474 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:o77430_drome(display_long)|uniprotkb:SkpA(gene name)|psi-mi:SkpA(display_short)|uniprotkb:Dredd(gene name synonym)|uniprotkb:"EG:115C2.4"(gene name synonym)|uniprotkb:skpA(gene name synonym)|uniprotkb:skpA-RC(gene name synonym)|uniprotkb:skpA-RH(gene name synonym)|uniprotkb:Dmel\CG16983(gene name synonym)|uniprotkb:SKP1(gene name synonym)|uniprotkb:SKPA(gene name synonym)|uniprotkb:Skp(gene name synonym)|uniprotkb:Skp1(gene name synonym)|uniprotkb:anon-WO03040301.234(gene name synonym)|uniprotkb:anon-WO03040301.236(gene name synonym)|uniprotkb:anon-WO03040301.238(gene name synonym)|uniprotkb:dSKP1(gene name synonym)|uniprotkb:dSkp-1(gene name synonym)|uniprotkb:dSkpA(gene name synonym)|uniprotkb:dskpA(gene name synonym)|uniprotkb:"l(1)G0037"(gene name synonym)|uniprotkb:"l(1)G0058"(gene name synonym)|uniprotkb:"l(1)G0109"(gene name synonym)|uniprotkb:"l(1)G0389"(gene name synonym)|uniprotkb:spkA(gene name synonym)|uniprotkb:Dmel_CG16983(orf name)|uniprotkb:CG16983(orf name)|uniprotkb:dSkip-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372778|imex:IM-15821-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001033818.1|refseq:NP_477390.1|refseq:NP_726690.1|refseq:NP_726691.1|refseq:NP_726692.1|refseq:NP_726693.1|refseq:NP_726694.1|refseq:NP_726695.1|flybase:FBgn0025637|refseq:NP_001284755.1|dip:DIP-18869N|ensemblmetazoa:FBgn0025637(gene)|ensemblmetazoa:FBtr0070123(transcript)|ensemblmetazoa:FBtr0070124(transcript)|ensemblmetazoa:FBtr0070125(transcript)|ensemblmetazoa:FBtr0070126(transcript)|ensemblmetazoa:FBtr0070127(transcript)|ensemblmetazoa:FBtr0070128(transcript)|ensemblmetazoa:FBtr0070129(transcript)|ensemblmetazoa:FBtr0100530(transcript)|ensemblmetazoa:FBtr0345314(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002785"(negative regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051298"(centrosome duplication)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:O77430|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-209360|reactome:R-DME-209461|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-68949|reactome:R-DME-69231|reactome:R-DME-8854050|reactome:R-DME-8939902|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-917937|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:o/doJAXzyTf6sKVVNWBxjFy5De07227 intact-crc:9F59DED334E6A29B|rigid:3kcRLmuM97wQIti9yGgyAiE4shc false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:O77430 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-180180|intact:EBI-1628435|ensemblmetazoa:FBpp0070118|ensemblmetazoa:FBpp0070119|ensemblmetazoa:FBpp0070120|ensemblmetazoa:FBpp0070121|ensemblmetazoa:FBpp0070122|ensemblmetazoa:FBpp0070123|ensemblmetazoa:FBpp0070124|ensemblmetazoa:FBpp0099971|ensemblmetazoa:FBpp0311474 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:o77430_drome(display_long)|uniprotkb:SkpA(gene name)|psi-mi:SkpA(display_short)|uniprotkb:Dredd(gene name synonym)|uniprotkb:"EG:115C2.4"(gene name synonym)|uniprotkb:skpA(gene name synonym)|uniprotkb:skpA-RC(gene name synonym)|uniprotkb:skpA-RH(gene name synonym)|uniprotkb:Dmel\CG16983(gene name synonym)|uniprotkb:SKP1(gene name synonym)|uniprotkb:SKPA(gene name synonym)|uniprotkb:Skp(gene name synonym)|uniprotkb:Skp1(gene name synonym)|uniprotkb:anon-WO03040301.234(gene name synonym)|uniprotkb:anon-WO03040301.236(gene name synonym)|uniprotkb:anon-WO03040301.238(gene name synonym)|uniprotkb:dSKP1(gene name synonym)|uniprotkb:dSkp-1(gene name synonym)|uniprotkb:dSkpA(gene name synonym)|uniprotkb:dskpA(gene name synonym)|uniprotkb:"l(1)G0037"(gene name synonym)|uniprotkb:"l(1)G0058"(gene name synonym)|uniprotkb:"l(1)G0109"(gene name synonym)|uniprotkb:"l(1)G0389"(gene name synonym)|uniprotkb:spkA(gene name synonym)|uniprotkb:Dmel_CG16983(orf name)|uniprotkb:CG16983(orf name)|uniprotkb:dSkip-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001033818.1|refseq:NP_477390.1|refseq:NP_726690.1|refseq:NP_726691.1|refseq:NP_726692.1|refseq:NP_726693.1|refseq:NP_726694.1|refseq:NP_726695.1|flybase:FBgn0025637|refseq:NP_001284755.1|dip:DIP-18869N|ensemblmetazoa:FBgn0025637(gene)|ensemblmetazoa:FBtr0070123(transcript)|ensemblmetazoa:FBtr0070124(transcript)|ensemblmetazoa:FBtr0070125(transcript)|ensemblmetazoa:FBtr0070126(transcript)|ensemblmetazoa:FBtr0070127(transcript)|ensemblmetazoa:FBtr0070128(transcript)|ensemblmetazoa:FBtr0070129(transcript)|ensemblmetazoa:FBtr0100530(transcript)|ensemblmetazoa:FBtr0345314(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002785"(negative regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051298"(centrosome duplication)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:O77430|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-209360|reactome:R-DME-209461|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-68949|reactome:R-DME-69231|reactome:R-DME-8854050|reactome:R-DME-8939902|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-917937|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:o/doJAXzyTf6sKVVNWBxjFy5De07227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q09024 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-113241|uniprotkb:Q6NLN1|uniprotkb:Q7KV52|uniprotkb:Q95SU7|uniprotkb:Q9VZF7|ensemblmetazoa:FBpp0073106 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:impl2_drome(display_long)|uniprotkb:ImpL2(gene name)|psi-mi:ImpL2(display_short)|uniprotkb:CG15009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_523921.3|refseq:NP_728960.1|refseq:NP_728961.2|flybase:FBgn0001257|interpro:IPR036179|rcsb pdb:4CBP|rcsb pdb:6FEY|rcsb pdb:6FF3|ensemblmetazoa:FBgn0001257(gene)|ensemblmetazoa:FBtr0073250(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042594"(response to starvation)|go:"GO:0043559"(insulin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001261409.1|dip:DIP-20664N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:r1KXgB4BcNcGVJUgPZhlGghY+bk7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:P09208 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q24311 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-136038|uniprotkb:A4UZ78|ensemblmetazoa:FBpp0087921|ensemblmetazoa:FBpp0087922|ensemblmetazoa:FBpp0087923|ensemblmetazoa:FBpp0087924|uniprotkb:Q0E9G0|uniprotkb:Q9V312 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:cul1_drome(display_long)|uniprotkb:Cul1(gene name)|psi-mi:Cul1(display_short)|uniprotkb:Lin-19 homolog protein(gene name synonym)|uniprotkb:cul-1(gene name synonym)|uniprotkb:lin19(gene name synonym)|uniprotkb:CG1877(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_523655.1|refseq:NP_724621.1|refseq:NP_724622.1|refseq:NP_724623.1|flybase:FBgn0015509|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904801"(positive regulation of neuron remodeling)|ensemblmetazoa:FBgn0015509(gene)|ensemblmetazoa:FBtr0088845(transcript)|ensemblmetazoa:FBtr0088846(transcript)|ensemblmetazoa:FBtr0088847(transcript)|ensemblmetazoa:FBtr0088848(transcript)|go:"GO:0002785"(negative regulation of antimicrobial peptide production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q24311|reactome:R-DME-187577|reactome:R-DME-195253|reactome:R-DME-209360|reactome:R-DME-209461|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-68949|reactome:R-DME-69231|reactome:R-DME-8854050|reactome:R-DME-8939902|reactome:R-DME-8951664|reactome:R-DME-9020702|reactome:R-DME-917937|reactome:R-DME-983168|dip:DIP-19461N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:uik6AV9MpfMBKBZoYZSxvCl5bTc7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q9VY77 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-124192|intact:EBI-499534|uniprotkb:Q8SZR9|ensemblmetazoa:FBpp0073665 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:ajuba_drome(display_long)|uniprotkb:jub(gene name)|psi-mi:jub(display_short)|uniprotkb:CG11063(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_572930.3|flybase:FBgn0030530|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045179"(apical cortex)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0140311"(protein sequestering activity)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0007010"(cytoskeleton organization)|interpro:IPR001781(Zinc finger, LIM-type)|reactome:R-DME-1234176|ensemblmetazoa:FBgn0030530(gene)|ensemblmetazoa:FBtr0073834(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005912"(adherens junction)|go:"GO:0006355"(regulation of transcription, DNA-templated) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:/KIdHRDO28JuRHNddyBMUjl/fqQ7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:P91634 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q8IPG1 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-3408063|ensemblmetazoa:FBpp0079245|ensemblmetazoa:FBpp0089341|ensemblmetazoa:FBpp0292228 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:q8ipg1_drome(display_long)|uniprotkb:8222(gene name synonym)|uniprotkb:CT24332(gene name synonym)|uniprotkb:DmVEGFR(gene name synonym)|uniprotkb:Dmel\CG8222(gene name synonym)|uniprotkb:PVR(gene name synonym)|uniprotkb:VEGFR(gene name synonym)|uniprotkb:VEGFR-A(gene name synonym)|uniprotkb:VGR1(gene name synonym)|uniprotkb:Vegf(gene name synonym)|uniprotkb:Vegfr(gene name synonym)|uniprotkb:Vegfr-b(gene name synonym)|uniprotkb:Vegfr-c(gene name synonym)|uniprotkb:Vgr1(gene name synonym)|uniprotkb:pvr(gene name synonym)|uniprotkb:stai(gene name synonym)|uniprotkb:vgr1(gene name synonym)|uniprotkb:Dmel_CG8222(orf name)|uniprotkb:Pvr(gene name)|psi-mi:Pvr(display_short)|uniprotkb:PvR(gene name synonym)|uniprotkb:CG8222(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001188721.1|refseq:NP_723365.1|refseq:NP_995649.1|flybase:FBgn0032006|ensemblmetazoa:FBgn0032006(gene)|ensemblmetazoa:FBtr0079626(transcript)|ensemblmetazoa:FBtr0079628(transcript)|ensemblmetazoa:FBtr0303109(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007419"(ventral cord development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030097"(hemopoiesis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:BvyysdOTXXxcNCzX4N83nZJ97HA7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q9VT01 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-89020|ensemblmetazoa:FBpp0076199 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:q9vt01_drome(display_long)|uniprotkb:Dmel_CG3428(orf name)|uniprotkb:pall(gene name)|psi-mi:pall(display_short)|uniprotkb:pall-RA(gene name synonym)|uniprotkb:CG3428(orf name)|uniprotkb:Dmel\CG3428(gene name synonym)|uniprotkb:FBXO1(gene name synonym)|uniprotkb:PALL(gene name synonym)|uniprotkb:Pall(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 ensemblmetazoa:FBgn0036005(gene)|ensemblmetazoa:FBtr0076471(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR039719|refseq:NP_648325.2|flybase:FBgn0036005 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:WXwSewe42Cv/KkRSp3LSdLgAvJQ7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O18683 uniprotkb:Q9XTN2 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604 psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372790|imex:IM-15821-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227 intact-crc:7D8452FC616DF27A|rigid:euq7gzzkojbk2x76EQ47mWEfEwQ false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:O18683 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372813|imex:IM-15821-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 intact-crc:7CC093313E88E653|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:A8DZ19 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-3430342|ensemblmetazoa:FBpp0307723|ensemblmetazoa:FBpp0428192 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:a8dz19_drome(display_long)|uniprotkb:RtGEF(gene name)|psi-mi:RtGEF(display_short)|uniprotkb:rtGEF(gene name synonym)|uniprotkb:Dmel_CG10043(orf name)|uniprotkb:38C.40(gene name synonym)|uniprotkb:ARHGEF7(gene name synonym)|uniprotkb:Dmel\CG10043(gene name synonym)|uniprotkb:DrhoGEF(gene name synonym)|uniprotkb:DrtGEF(gene name synonym)|uniprotkb:Pix(gene name synonym)|uniprotkb:RacGEF(gene name synonym)|uniprotkb:Rho(gene name synonym)|uniprotkb:RhoGEF(gene name synonym)|uniprotkb:beta-PIX(gene name synonym)|uniprotkb:betaPIX(gene name synonym)|uniprotkb:dPix(gene name synonym)|uniprotkb:dpix(gene name synonym)|uniprotkb:pix(gene name synonym)|uniprotkb:rhoGEF(gene name synonym)|uniprotkb:CG10043(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372813|imex:IM-15821-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 refseq:NP_001097184.2|flybase:FBgn0015803|ensemblmetazoa:FBgn0015803(gene)|ensemblmetazoa:FBtr0336747(transcript)|ensemblmetazoa:FBtr0479856(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-DME-416482|reactome:R-DME-446388|reactome:R-DME-8964616|reactome:R-DME-8980692|reactome:R-DME-9013148|reactome:R-DME-9013149|reactome:R-DME-9013406|reactome:R-DME-9013420|reactome:R-DME-9013424|interpro:IPR035899|interpro:IPR036028|reactome:R-DME-182971|reactome:R-DME-193648|reactome:R-DME-3928664 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:/y1IHFXPaMra2ru0WlvIbNmEzn87227 intact-crc:7CC093313E88E653|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:Q95RG8 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-164241|uniprotkb:Q9V5N5|ensemblmetazoa:FBpp0087353 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:git_drome(display_long)|uniprotkb:Git(gene name)|psi-mi:Git(display_short)|uniprotkb:arfgap2(gene name synonym)|uniprotkb:CG16728(orf name)|uniprotkb:G protein-coupled receptor kinase interacting ArfGAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372813|imex:IM-15821-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 refseq:NP_610599.3|flybase:FBgn0033539|ensemblmetazoa:FBgn0033539(gene)|ensemblmetazoa:FBtr0088258(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007525"(somatic muscle development)|go:"GO:0016319"(mushroom body development)|go:"GO:0030027"(lamellipodium)|go:"GO:0031252"(cell leading edge)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0099504"(synaptic vesicle cycle)|go:"GO:1905383"(protein localization to presynapse)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|reactome:R-DME-3928664|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013406|reactome:R-DME-9013420|reactome:R-DME-9013424 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:Gn0hmU1j7mQnJtDTt3Q0Vhx18tg7227 intact-crc:7CC093313E88E653|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:O18683 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-136889|uniprotkb:Q95SY4|uniprotkb:Q9VPN6|ensemblmetazoa:FBpp0303635 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:o18683_drome(display_long)|uniprotkb:Pi3K21B(gene name)|psi-mi:Pi3K21B(display_short)|uniprotkb:droPIK57(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:CG2699(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372806|imex:IM-15821-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 flybase:FBgn0020622|ensemblmetazoa:FBgn0020622(gene)|ensemblmetazoa:FBtr0331208(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016301"(kinase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|reactome:R-DME-110478 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:cdOgMluWy8oZsnsqWrhsxv1GfSg7227 intact-crc:0FBAF12B4A8AB173|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:Q95RG8 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-164241|uniprotkb:Q9V5N5|ensemblmetazoa:FBpp0087353 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:git_drome(display_long)|uniprotkb:Git(gene name)|psi-mi:Git(display_short)|uniprotkb:arfgap2(gene name synonym)|uniprotkb:CG16728(orf name)|uniprotkb:G protein-coupled receptor kinase interacting ArfGAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372806|imex:IM-15821-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 refseq:NP_610599.3|flybase:FBgn0033539|ensemblmetazoa:FBgn0033539(gene)|ensemblmetazoa:FBtr0088258(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007525"(somatic muscle development)|go:"GO:0016319"(mushroom body development)|go:"GO:0030027"(lamellipodium)|go:"GO:0031252"(cell leading edge)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0099504"(synaptic vesicle cycle)|go:"GO:1905383"(protein localization to presynapse)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|reactome:R-DME-3928664|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013406|reactome:R-DME-9013420|reactome:R-DME-9013424 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:Gn0hmU1j7mQnJtDTt3Q0Vhx18tg7227 intact-crc:0FBAF12B4A8AB173|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91634 uniprotkb:A8DZ19 intact:EBI-173369|ensemblmetazoa:FBpp0083348|ensemblmetazoa:FBpp0083349|ensemblmetazoa:FBpp0306705 intact:EBI-3430342|ensemblmetazoa:FBpp0307723|ensemblmetazoa:FBpp0428192 psi-mi:p91634_drome(display_long)|uniprotkb:Pi3K92E(gene name)|psi-mi:Pi3K92E(display_short)|uniprotkb:dp110(gene name synonym)|uniprotkb:DP110(gene name synonym)|uniprotkb:Dmel\CG4141(gene name synonym)|uniprotkb:Dmp110(gene name synonym)|uniprotkb:Dp110(gene name synonym)|uniprotkb:Dpp110(gene name synonym)|uniprotkb:"PI(3)K"(gene name synonym)|uniprotkb:PI-3 kinase(gene name synonym)|uniprotkb:PI-3-K(gene name synonym)|uniprotkb:PI3'K(gene name synonym)|uniprotkb:PI3K(gene name synonym)|uniprotkb:PI3K-92D(gene name synonym)|uniprotkb:PI3K-92E(gene name synonym)|uniprotkb:PI3K-Dp110(gene name synonym)|uniprotkb:PI3K-I(gene name synonym)|uniprotkb:PI3K-dp110(gene name synonym)|uniprotkb:PI3K92E(gene name synonym)|uniprotkb:PI3k(gene name synonym)|uniprotkb:PI[[3]]K(gene name synonym)|uniprotkb:Pi3K(gene name synonym)|uniprotkb:Pi3K92D(gene name synonym)|uniprotkb:"Pi3K92E|p110"(gene name synonym)|uniprotkb:Pi3Kp110(gene name synonym)|uniprotkb:Pi3k(gene name synonym)|uniprotkb:Pi3k92e(gene name synonym)|uniprotkb:PiK92E(gene name synonym)|uniprotkb:anon-92Ed(gene name synonym)|uniprotkb:dP110(gene name synonym)|uniprotkb:dP13K(gene name synonym)|uniprotkb:dPI3K(gene name synonym)|uniprotkb:dPI3K[92E](gene name synonym)|uniprotkb:dp110alpha(gene name synonym)|uniprotkb:p110(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pi3k(gene name synonym)|uniprotkb:pi3k92e(gene name synonym)|uniprotkb:rea(gene name synonym)|uniprotkb:type-1 PI3K(gene name synonym)|uniprotkb:Dmel_CG4141(orf name)|uniprotkb:CG4141(orf name)|uniprotkb:dpP110(gene name synonym)|uniprotkb:pi3k92E(gene name synonym) psi-mi:a8dz19_drome(display_long)|uniprotkb:RtGEF(gene name)|psi-mi:RtGEF(display_short)|uniprotkb:rtGEF(gene name synonym)|uniprotkb:Dmel_CG10043(orf name)|uniprotkb:38C.40(gene name synonym)|uniprotkb:ARHGEF7(gene name synonym)|uniprotkb:Dmel\CG10043(gene name synonym)|uniprotkb:DrhoGEF(gene name synonym)|uniprotkb:DrtGEF(gene name synonym)|uniprotkb:Pix(gene name synonym)|uniprotkb:RacGEF(gene name synonym)|uniprotkb:Rho(gene name synonym)|uniprotkb:RhoGEF(gene name synonym)|uniprotkb:beta-PIX(gene name synonym)|uniprotkb:betaPIX(gene name synonym)|uniprotkb:dPix(gene name synonym)|uniprotkb:dpix(gene name synonym)|uniprotkb:pix(gene name synonym)|uniprotkb:rhoGEF(gene name synonym)|uniprotkb:CG10043(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372806|imex:IM-15821-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650902.1|refseq:NP_732536.1|flybase:FBgn0015279|refseq:NP_001262770.1|dip:DIP-21625N|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045615"(positive regulation of plasmatocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035205"(positive regulation of lamellocyte differentiation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|ensemblmetazoa:FBgn0015279(gene)|ensemblmetazoa:FBtr0083940(transcript)|ensemblmetazoa:FBtr0083941(transcript)|ensemblmetazoa:FBtr0334643(transcript)|go:"GO:0002164"(larval development)|go:"GO:0002168"(instar larval development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007552"(metamorphosis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055115"(entry into diapause)|go:"GO:0060074"(synapse maturation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-114604|reactome:R-DME-1257604|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|reactome:R-DME-186763|reactome:R-DME-198203|reactome:R-DME-2730905|reactome:R-DME-4420097|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-9027276|reactome:R-DME-912631|reactome:R-DME-983695|reactome:R-DME-1660499 refseq:NP_001097184.2|flybase:FBgn0015803|ensemblmetazoa:FBgn0015803(gene)|ensemblmetazoa:FBtr0336747(transcript)|ensemblmetazoa:FBtr0479856(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-DME-416482|reactome:R-DME-446388|reactome:R-DME-8964616|reactome:R-DME-8980692|reactome:R-DME-9013148|reactome:R-DME-9013149|reactome:R-DME-9013406|reactome:R-DME-9013420|reactome:R-DME-9013424|interpro:IPR035899|interpro:IPR036028|reactome:R-DME-182971|reactome:R-DME-193648|reactome:R-DME-3928664 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:6bV8IAtaMmbU7LHLOfyw1BGed/Q7227 rogid:/y1IHFXPaMra2ru0WlvIbNmEzn87227 intact-crc:0FBAF12B4A8AB173|rigid:8ZNQLKMLfFTeSHIjJ76OSvV6zb0 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:P92177 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372849|imex:IM-15821-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:531D0ABD8319EDEE|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:P29310 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372849|imex:IM-15821-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:531D0ABD8319EDEE|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:Q9VCC9 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-195778|ensemblmetazoa:FBpp0083931 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372849|imex:IM-15821-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 intact-crc:531D0ABD8319EDEE|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:Q9VCC4 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-171534|ensemblmetazoa:FBpp0083936 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:q9vcc4_drome(display_long)|uniprotkb:TBC1d7(gene name)|psi-mi:TBC1d7(display_short)|uniprotkb:"BcDNA:LD17019"(gene name synonym)|uniprotkb:Dmel\CG6182(gene name synonym)|uniprotkb:TBC1D7(gene name synonym)|uniprotkb:dTBC1D7(gene name synonym)|uniprotkb:CG6182(orf name)|uniprotkb:Dmel_CG6182(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372849|imex:IM-15821-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_651223.2|flybase:FBgn0039158|ensemblmetazoa:FBgn0039158(gene)|ensemblmetazoa:FBtr0084551(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0062078"(TSC1-TSC2 complex binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|interpro:IPR039842|interpro:IPR043039|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:/RldCB4EWCILpv9hDw6leeBjQOE7227 intact-crc:531D0ABD8319EDEE|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:Q9VCC4 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-171534|ensemblmetazoa:FBpp0083936 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:q9vcc4_drome(display_long)|uniprotkb:TBC1d7(gene name)|psi-mi:TBC1d7(display_short)|uniprotkb:"BcDNA:LD17019"(gene name synonym)|uniprotkb:Dmel\CG6182(gene name synonym)|uniprotkb:TBC1D7(gene name synonym)|uniprotkb:dTBC1D7(gene name synonym)|uniprotkb:CG6182(orf name)|uniprotkb:Dmel_CG6182(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372859|imex:IM-15821-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_651223.2|flybase:FBgn0039158|ensemblmetazoa:FBgn0039158(gene)|ensemblmetazoa:FBtr0084551(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0062078"(TSC1-TSC2 complex binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|interpro:IPR039842|interpro:IPR043039|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:/RldCB4EWCILpv9hDw6leeBjQOE7227 intact-crc:00493F96C51E2FC0|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:P29310 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372859|imex:IM-15821-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:00493F96C51E2FC0|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:P92177 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372859|imex:IM-15821-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:00493F96C51E2FC0|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VW83 uniprotkb:Q9VCC9 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 intact:EBI-195778|ensemblmetazoa:FBpp0083931 psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372859|imex:IM-15821-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 intact-crc:00493F96C51E2FC0|rigid:EAfvrCwlOup7ma4BbQzfE+60EZA false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:P92177 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372869|imex:IM-15821-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:FB031CA378863703|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q0KI87 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-93158|intact:EBI-3407233|ensemblmetazoa:FBpp0293891|ensemblmetazoa:FBpp0293892|ensemblmetazoa:FBpp0293893 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q0ki87_drome(display_long)|uniprotkb:Nuak(gene name)|psi-mi:Nuak(display_short)|uniprotkb:CG11870(gene name synonym)|uniprotkb:CG11871(gene name synonym)|uniprotkb:CG11872(gene name synonym)|uniprotkb:Dmel\CG43143(gene name synonym)|uniprotkb:EMK(gene name synonym)|uniprotkb:KIAA0537(gene name synonym)|uniprotkb:NUAK(gene name synonym)|uniprotkb:Nuak1(gene name synonym)|uniprotkb:Omphk1(gene name synonym)|uniprotkb:CG43143(orf name)|uniprotkb:Dmel_CG43143(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372869|imex:IM-15821-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_649991.2|refseq:NP_731469.2|refseq:NP_996192.1|flybase:FBgn0262617|ensemblmetazoa:FBgn0262617(gene)|ensemblmetazoa:FBtr0305352(transcript)|ensemblmetazoa:FBtr0305353(transcript)|ensemblmetazoa:FBtr0305354(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:khKMw5OznaTs28mOqhyz0Djn9+A7227 intact-crc:FB031CA378863703|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q9VCC4 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-171534|ensemblmetazoa:FBpp0083936 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q9vcc4_drome(display_long)|uniprotkb:TBC1d7(gene name)|psi-mi:TBC1d7(display_short)|uniprotkb:"BcDNA:LD17019"(gene name synonym)|uniprotkb:Dmel\CG6182(gene name synonym)|uniprotkb:TBC1D7(gene name synonym)|uniprotkb:dTBC1D7(gene name synonym)|uniprotkb:CG6182(orf name)|uniprotkb:Dmel_CG6182(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372869|imex:IM-15821-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_651223.2|flybase:FBgn0039158|ensemblmetazoa:FBgn0039158(gene)|ensemblmetazoa:FBtr0084551(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0062078"(TSC1-TSC2 complex binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|interpro:IPR039842|interpro:IPR043039|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:/RldCB4EWCILpv9hDw6leeBjQOE7227 intact-crc:FB031CA378863703|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q9VW83 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372869|imex:IM-15821-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 intact-crc:FB031CA378863703|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:P29310 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372869|imex:IM-15821-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:FB031CA378863703|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q9VW83 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372880|imex:IM-15821-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 intact-crc:A1216788D300D45F|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q0KI87 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-93158|intact:EBI-3407233|ensemblmetazoa:FBpp0293891|ensemblmetazoa:FBpp0293892|ensemblmetazoa:FBpp0293893 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q0ki87_drome(display_long)|uniprotkb:Nuak(gene name)|psi-mi:Nuak(display_short)|uniprotkb:CG11870(gene name synonym)|uniprotkb:CG11871(gene name synonym)|uniprotkb:CG11872(gene name synonym)|uniprotkb:Dmel\CG43143(gene name synonym)|uniprotkb:EMK(gene name synonym)|uniprotkb:KIAA0537(gene name synonym)|uniprotkb:NUAK(gene name synonym)|uniprotkb:Nuak1(gene name synonym)|uniprotkb:Omphk1(gene name synonym)|uniprotkb:CG43143(orf name)|uniprotkb:Dmel_CG43143(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372880|imex:IM-15821-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_649991.2|refseq:NP_731469.2|refseq:NP_996192.1|flybase:FBgn0262617|ensemblmetazoa:FBgn0262617(gene)|ensemblmetazoa:FBtr0305352(transcript)|ensemblmetazoa:FBtr0305353(transcript)|ensemblmetazoa:FBtr0305354(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:khKMw5OznaTs28mOqhyz0Djn9+A7227 intact-crc:A1216788D300D45F|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:P92177 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-204478|uniprotkb:Q8IN86|intact:EBI-458717|uniprotkb:Q8IN87|uniprotkb:Q9VEA8|ensemblmetazoa:FBpp0082987 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:1433e_drome(display_long)|uniprotkb:14-3-3epsilon(gene name)|psi-mi:14-3-3epsilon(display_short)|uniprotkb:14-3-3e(gene name synonym)|uniprotkb:SR3-9(gene name synonym)|uniprotkb:Suppressor of Ras1 3-9(gene name synonym)|uniprotkb:CG31196(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372880|imex:IM-15821-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_732309.1|refseq:NP_732310.1|refseq:NP_732311.1|refseq:NP_732312.1|flybase:FBgn0020238|dip:DIP-18498N|ensemblmetazoa:FBgn0020238(gene)|ensemblmetazoa:FBtr0083565(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007280"(pole cell migration)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007411"(axon guidance)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0150013"(negative regulation of neuron projection arborization)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P92177|reactome:R-DME-2028269|reactome:R-DME-3371453|reactome:R-DME-3371511|reactome:R-DME-390098|reactome:R-DME-432553|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-75035|reactome:R-DME-8876198 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:VyaKt/NXQIB+SaXr0gONlnAU1ws7227 intact-crc:A1216788D300D45F|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:P29310 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-198100|intact:EBI-1630797|uniprotkb:A4UZB2|uniprotkb:A4UZB3|uniprotkb:O01665|uniprotkb:Q0E9D5|uniprotkb:Q0E9D6|uniprotkb:Q0E9D7|uniprotkb:Q8IGB9|uniprotkb:Q8MKV5|uniprotkb:Q9V5G6|uniprotkb:C1C593|uniprotkb:C9QP27|ensemblmetazoa:FBpp0087502|ensemblmetazoa:FBpp0087503|ensemblmetazoa:FBpp0099540|ensemblmetazoa:FBpp0305136|ensemblmetazoa:FBpp0305137 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:1433z_drome(display_long)|uniprotkb:14-3-3zeta(gene name)|psi-mi:14-3-3zeta(display_short)|uniprotkb:14-3-3EZ(gene name synonym)|uniprotkb:leo(gene name synonym)|uniprotkb:14-3-3(gene name synonym)|uniprotkb:THAP(gene name synonym)|uniprotkb:CG17870(orf name)|uniprotkb:14-3-3-like protein(gene name synonym)|uniprotkb:Protein Leonardo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372880|imex:IM-15821-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_001260845.1|refseq:NP_001260846.1|refseq:NP_001014515.1|refseq:NP_001014516.1|refseq:NP_476885.2|refseq:NP_724884.1|refseq:NP_724885.1|refseq:NP_724886.1|refseq:NP_724887.2|refseq:NP_724888.2|refseq:NP_724889.2|refseq:NP_995792.1|flybase:FBgn0004907|dip:DIP-17371N|ensemblmetazoa:FBgn0004907(gene)|ensemblmetazoa:FBtr0088414(transcript)|ensemblmetazoa:FBtr0088415(transcript)|ensemblmetazoa:FBtr0100183(transcript)|ensemblmetazoa:FBtr0332916(transcript)|ensemblmetazoa:FBtr0332917(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007399"(nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0008103"(oocyte microtubule cytoskeleton polarization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0040040"(thermosensory behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045172"(germline ring canal)|go:"GO:0045448"(mitotic cell cycle, embryonic)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-170968|reactome:R-DME-2028269|reactome:R-DME-3769402|reactome:R-DME-390098|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-450385|reactome:R-DME-450513|reactome:R-DME-450604|reactome:R-DME-5625740|reactome:R-DME-5628897|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|reactome:R-DME-6804114|reactome:R-DME-75035|reactome:R-DME-9013700|reactome:R-DME-9614399 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:G1jZJfZZqZwEu9lekPYYdvZAXO87227 intact-crc:A1216788D300D45F|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VCC9 uniprotkb:Q9VCC4 intact:EBI-195778|ensemblmetazoa:FBpp0083931 intact:EBI-171534|ensemblmetazoa:FBpp0083936 psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:q9vcc4_drome(display_long)|uniprotkb:TBC1d7(gene name)|psi-mi:TBC1d7(display_short)|uniprotkb:"BcDNA:LD17019"(gene name synonym)|uniprotkb:Dmel\CG6182(gene name synonym)|uniprotkb:TBC1D7(gene name synonym)|uniprotkb:dTBC1D7(gene name synonym)|uniprotkb:CG6182(orf name)|uniprotkb:Dmel_CG6182(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372880|imex:IM-15821-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 refseq:NP_651223.2|flybase:FBgn0039158|ensemblmetazoa:FBgn0039158(gene)|ensemblmetazoa:FBtr0084551(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0062078"(TSC1-TSC2 complex binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|interpro:IPR039842|interpro:IPR043039|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 rogid:/RldCB4EWCILpv9hDw6leeBjQOE7227 intact-crc:A1216788D300D45F|rigid:CsNrwvkDCYLnm6g7crDvUbVFM2s false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VND8 uniprotkb:Q9VW83 intact:EBI-4372932|uniprotkb:Q0KIB7|ensemblmetazoa:FBpp0078342|ensemblmetazoa:FBpp0078343 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 psi-mi:rheb_drome(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:CG1081(orf name) psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372958|imex:IM-15821-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_730950.2|refseq:NP_730951.2|flybase:FBgn0041191|dip:DIP-60269N|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019003"(GDP binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042594"(response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045176"(apical protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903940"(negative regulation of TORC2 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904503"(negative regulation of lipophagy)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|reactome:R-DME-110523|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0041191(gene)|ensemblmetazoa:FBtr0078693(transcript)|ensemblmetazoa:FBtr0078694(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003924"(GTPase activity) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:a8qIHNMXIA6UhaQLWTnjsAvW8OY7227 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 intact-crc:C6549C6C42AD2B6C|rigid:vZ8h5hzk68Sa5HzcmJaTqpQxV98 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VND8 uniprotkb:Q9VCC9 intact:EBI-4372932|uniprotkb:Q0KIB7|ensemblmetazoa:FBpp0078342|ensemblmetazoa:FBpp0078343 intact:EBI-195778|ensemblmetazoa:FBpp0083931 psi-mi:rheb_drome(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:CG1081(orf name) psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372958|imex:IM-15821-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_730950.2|refseq:NP_730951.2|flybase:FBgn0041191|dip:DIP-60269N|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019003"(GDP binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042594"(response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045176"(apical protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903940"(negative regulation of TORC2 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904503"(negative regulation of lipophagy)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|reactome:R-DME-110523|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0041191(gene)|ensemblmetazoa:FBtr0078693(transcript)|ensemblmetazoa:FBtr0078694(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003924"(GTPase activity) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:a8qIHNMXIA6UhaQLWTnjsAvW8OY7227 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 intact-crc:C6549C6C42AD2B6C|rigid:vZ8h5hzk68Sa5HzcmJaTqpQxV98 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VND8 uniprotkb:Q9VW83 intact:EBI-4372932|uniprotkb:Q0KIB7|ensemblmetazoa:FBpp0078342|ensemblmetazoa:FBpp0078343 intact:EBI-4372820|ensemblmetazoa:FBpp0074588 psi-mi:rheb_drome(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:CG1081(orf name) psi-mi:q9vw83_drome(display_long)|uniprotkb:gig(gene name)|psi-mi:gig(display_short)|uniprotkb:6975(gene name synonym)|uniprotkb:C1(gene name synonym)|uniprotkb:Dmel\CG6975(gene name synonym)|uniprotkb:FBpp0074588(gene name synonym)|uniprotkb:Gigas(gene name synonym)|uniprotkb:ME 109(gene name synonym)|uniprotkb:TSC2(gene name synonym)|uniprotkb:Tsc2(gene name synonym)|uniprotkb:dTSC2(gene name synonym)|uniprotkb:dTsc2(gene name synonym)|uniprotkb:"gig|Tsc2"(gene name synonym)|uniprotkb:"l(3)109"(gene name synonym)|uniprotkb:tsc2(gene name synonym)|uniprotkb:Dmel_CG6975(orf name)|uniprotkb:CG6975(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372964|imex:IM-15821-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_730950.2|refseq:NP_730951.2|flybase:FBgn0041191|dip:DIP-60269N|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019003"(GDP binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042594"(response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045176"(apical protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903940"(negative regulation of TORC2 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904503"(negative regulation of lipophagy)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|reactome:R-DME-110523|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0041191(gene)|ensemblmetazoa:FBtr0078693(transcript)|ensemblmetazoa:FBtr0078694(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003924"(GTPase activity) refseq:NP_524177.1|flybase:FBgn0005198|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensemblmetazoa:FBgn0005198(gene)|ensemblmetazoa:FBtr0074819(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|reactome:R-DME-1632852|go:"GO:0051726"(regulation of cell cycle)|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:a8qIHNMXIA6UhaQLWTnjsAvW8OY7227 rogid:1reQsJR+qb55sNjh1BEyuzCemXY7227 intact-crc:B132CADF53CFEE74|rigid:vZ8h5hzk68Sa5HzcmJaTqpQxV98 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VND8 uniprotkb:Q9VCC9 intact:EBI-4372932|uniprotkb:Q0KIB7|ensemblmetazoa:FBpp0078342|ensemblmetazoa:FBpp0078343 intact:EBI-195778|ensemblmetazoa:FBpp0083931 psi-mi:rheb_drome(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:CG1081(orf name) psi-mi:q9vcc9_drome(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Dmel\CG6147(gene name synonym)|uniprotkb:TSC(gene name synonym)|uniprotkb:TSC1(gene name synonym)|uniprotkb:dTSC(gene name synonym)|uniprotkb:dTSC-1(gene name synonym)|uniprotkb:dTSC1(gene name synonym)|uniprotkb:dTsc1(gene name synonym)|uniprotkb:dtsc1(gene name synonym)|uniprotkb:rocky(gene name synonym)|uniprotkb:tsc1(gene name synonym)|uniprotkb:Dmel_CG6147(orf name)|uniprotkb:CG6147(orf name)|uniprotkb:Tsc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372964|imex:IM-15821-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_730950.2|refseq:NP_730951.2|flybase:FBgn0041191|dip:DIP-60269N|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019003"(GDP binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042594"(response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045176"(apical protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903940"(negative regulation of TORC2 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904503"(negative regulation of lipophagy)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|reactome:R-DME-110523|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0041191(gene)|ensemblmetazoa:FBtr0078693(transcript)|ensemblmetazoa:FBtr0078694(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003924"(GTPase activity) flybase:FBgn0026317|refseq:NP_477415.1|ensemblmetazoa:FBgn0026317(gene)|ensemblmetazoa:FBtr0084546(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0035069"(larval midgut histolysis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048542"(lymph gland development)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR007483(Hamartin)|reactome:R-DME-1632852|reactome:R-DME-165181|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8854214 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:a8qIHNMXIA6UhaQLWTnjsAvW8OY7227 rogid:cj5XMRlsFzzFGpS0OEJBV/mJ8WI7227 intact-crc:B132CADF53CFEE74|rigid:vZ8h5hzk68Sa5HzcmJaTqpQxV98 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q9VK45 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372976|imex:IM-15821-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:A311CEDC433768A1|rigid:je5foVjbBRg3nkc8e2z3X5QpZ2Q false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q86B79 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-90517|uniprotkb:A4V397|uniprotkb:Q24580|uniprotkb:Q5BIG8|uniprotkb:Q960U9|ensemblmetazoa:FBpp0083794|ensemblmetazoa:FBpp0083795|ensemblmetazoa:FBpp0294022|ensemblmetazoa:FBpp0294024 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:unk_drome(display_long)|uniprotkb:unk(gene name)|psi-mi:unk(display_short)|uniprotkb:CG4620(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372976|imex:IM-15821-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 refseq:NP_788722.1|refseq:NP_788723.1|flybase:FBgn0004395|ensemblmetazoa:FBgn0004395(gene)|ensemblmetazoa:FBtr0084402(transcript)|ensemblmetazoa:FBtr0084403(transcript)|reactome:R-DME-983168|ensemblmetazoa:FBtr0305571(transcript)|ensemblmetazoa:FBtr0305573(transcript)|go:"GO:0002164"(larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0048749"(compound eye development)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036855|interpro:IPR040594|refseq:NP_001247253.1|refseq:NP_001247255.1|dip:DIP-22281N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:pztbiDLfnl1a//Vwv5SUBzzb1vQ7227 intact-crc:A311CEDC433768A1|rigid:je5foVjbBRg3nkc8e2z3X5QpZ2Q false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q7JXA2 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372976|imex:IM-15821-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:A311CEDC433768A1|rigid:je5foVjbBRg3nkc8e2z3X5QpZ2Q false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q9W328 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372976|imex:IM-15821-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:A311CEDC433768A1|rigid:je5foVjbBRg3nkc8e2z3X5QpZ2Q false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q7JXA2 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-138419|intact:EBI-3423081|ensemblmetazoa:FBpp0312548 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:q7jxa2_drome(display_long)|uniprotkb:PRAS40(gene name)|psi-mi:PRAS40(display_short)|uniprotkb:L(gene name synonym)|uniprotkb:CG10109(gene name synonym)|uniprotkb:Dmel\CG46146(gene name synonym)|uniprotkb:dPRAS40(gene name synonym)|uniprotkb:CG46146(orf name)|uniprotkb:Dmel_CG46146(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372970|imex:IM-15821-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 ensemblmetazoa:FBgn0267824(gene)|ensemblmetazoa:FBtr0347396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR026682|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-198323|reactome:R-DME-3371571|flybase:FBgn0267824|refseq:NP_001303349.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:9IsL1C/o6KvLHG2TYWgJ95cSpgY7227 intact-crc:A9EF60F7DEE3532B|rigid:YoyVjic24M4a7kCfwUIfq2H6xNo false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q9W328 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-115381|uniprotkb:Q95RK5|ensemblmetazoa:FBpp0071303 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:lst8_drome(display_long)|uniprotkb:Lst8(gene name)|psi-mi:Lst8(display_short)|uniprotkb:CG3004(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372970|imex:IM-15821-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 refseq:NP_572572.1|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|ensemblmetazoa:FBgn0264691(gene)|ensemblmetazoa:FBtr0071368(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|flybase:FBgn0264691 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:yxTHsBTIC5gZOQE356xq3NFAWIE7227 intact-crc:A9EF60F7DEE3532B|rigid:YoyVjic24M4a7kCfwUIfq2H6xNo false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9W437 uniprotkb:Q9VK45 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 intact:EBI-2507751|ensemblmetazoa:FBpp0080003 psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:tor_drome(display_long)|uniprotkb:Tor(gene name)|psi-mi:Tor(display_short)|uniprotkb:Target of rapamycin(gene name synonym)|uniprotkb:CG5092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372970|imex:IM-15821-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 ensemblmetazoa:FBgn0021796(gene)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0031490"(chromatin DNA binding)|ensemblmetazoa:FBtr0080422(transcript)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090070"(positive regulation of ribosome biogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR019734|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|reactome:R-DME-1257604|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-389357|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|refseq:NP_524891.1|flybase:FBgn0021796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 rogid:LlBCKN0cL7mO9mJ6GBtG3qHMX8o7227 intact-crc:A9EF60F7DEE3532B|rigid:YoyVjic24M4a7kCfwUIfq2H6xNo false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91656 uniprotkb:Q24276 intact:EBI-466629 intact:EBI-167469|ensemblmetazoa:FBpp0072660 psi-mi:p91656_drome(display_long)|uniprotkb:CG10539(orf name)|uniprotkb:S6k(gene name)|psi-mi:S6k(display_short) psi-mi:cdc37_drome(display_long)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Protein enhancer of sevenless 3B(gene name synonym)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:"E(sev)3B"(gene name synonym)|uniprotkb:CG12019(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372985|imex:IM-15821-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0283472|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0031929"(TOR signaling)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-DME-110523|go:"GO:0008340"(determination of adult lifespan) refseq:NP_477006.1|flybase:FBgn0011573|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-DME-114608|reactome:R-DME-1227986|reactome:R-DME-5675482|reactome:R-DME-8863795|reactome:R-DME-9013418|reactome:R-DME-9652282|ensemblmetazoa:FBtr0072777(transcript)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|ensemblmetazoa:FBgn0011573(gene)|dip:DIP-20334N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:vY523/d3IX+Jh8UXjlIJaVVGFuw7227 rogid:VVPVuu4EBCGOAW2KN6faP0ADlEg7227 intact-crc:57489374629FF96A|rigid:oWQTPjSeaS5G7CD1e0TKqvfTxfs false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91656 uniprotkb:Q24276 intact:EBI-466629 intact:EBI-167469|ensemblmetazoa:FBpp0072660 psi-mi:p91656_drome(display_long)|uniprotkb:CG10539(orf name)|uniprotkb:S6k(gene name)|psi-mi:S6k(display_short) psi-mi:cdc37_drome(display_long)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Protein enhancer of sevenless 3B(gene name synonym)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:"E(sev)3B"(gene name synonym)|uniprotkb:CG12019(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372993|imex:IM-15821-28 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0283472|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0031929"(TOR signaling)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-DME-110523|go:"GO:0008340"(determination of adult lifespan) refseq:NP_477006.1|flybase:FBgn0011573|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-DME-114608|reactome:R-DME-1227986|reactome:R-DME-5675482|reactome:R-DME-8863795|reactome:R-DME-9013418|reactome:R-DME-9652282|ensemblmetazoa:FBtr0072777(transcript)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007059"(chromosome segregation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|ensemblmetazoa:FBgn0011573(gene)|dip:DIP-20334N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:vY523/d3IX+Jh8UXjlIJaVVGFuw7227 rogid:VVPVuu4EBCGOAW2KN6faP0ADlEg7227 intact-crc:D723D9F4A8A4B018|rigid:tPh09ngP6JTVEaa1qqWjQtmoHI8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P91656 uniprotkb:Q9W437 intact:EBI-466629 intact:EBI-3404045|ensemblmetazoa:FBpp0305180|ensemblmetazoa:FBpp0311819 psi-mi:p91656_drome(display_long)|uniprotkb:CG10539(orf name)|uniprotkb:S6k(gene name)|psi-mi:S6k(display_short) psi-mi:q9w437_drome(display_long)|uniprotkb:raptor(gene name)|psi-mi:raptor(display_short)|uniprotkb:CG4320(orf name)|uniprotkb:4320(gene name synonym)|uniprotkb:Dmel\CG4320(gene name synonym)|uniprotkb:Raptor(gene name synonym)|uniprotkb:dRap(gene name synonym)|uniprotkb:dRaptor(gene name synonym)|uniprotkb:Dmel_CG4320(orf name)|uniprotkb:dRAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4372993|imex:IM-15821-28 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0283472|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030536"(larval feeding behavior)|go:"GO:0031929"(TOR signaling)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-DME-110523|go:"GO:0008340"(determination of adult lifespan) ensemblmetazoa:FBgn0029840(gene)|ensemblmetazoa:FBtr0332964(transcript)|ensemblmetazoa:FBtr0345895(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0007517"(muscle organ development)|go:"GO:0007562"(eclosion)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048477"(oogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-DME-1632852|reactome:R-DME-165159|reactome:R-DME-166208|reactome:R-DME-3371571|reactome:R-DME-380972|reactome:R-DME-5628897|reactome:R-DME-8943724|reactome:R-DME-9639288|go:"GO:0030674"(protein-macromolecule adaptor activity)|refseq:NP_001284924.1|refseq:NP_572294.2|flybase:FBgn0029840 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2014/10/16 rogid:vY523/d3IX+Jh8UXjlIJaVVGFuw7227 rogid:fw7v8fbvTveb2gwQfh6hGQIwrss7227 intact-crc:D723D9F4A8A4B018|rigid:tPh09ngP6JTVEaa1qqWjQtmoHI8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:A8JNI2 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4373007|ensemblmetazoa:FBpp0292226 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:a8jni2_drome(display_long)|uniprotkb:Srrm234(gene name)|psi-mi:Srrm234(display_short)|uniprotkb:"BcDNA:GH04236"(gene name synonym)|uniprotkb:Dmel\CG7971(gene name synonym)|uniprotkb:SRm300(gene name synonym)|uniprotkb:"anon-EST:fe1A7"(gene name synonym)|uniprotkb:CG7971(orf name)|uniprotkb:Dmel_CG7971(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_001097475.2|flybase:FBgn0035253|ensemblmetazoa:FBgn0035253(gene)|ensemblmetazoa:FBtr0303107(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:4KFYjwJgU46h42Yf3KeWMPCsxHA7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q8I8U7 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-2507795|ensemblmetazoa:FBpp0292385|uniprotkb:Q8T3L7|uniprotkb:Q9V9E9|intact:EBI-2549785|intact:EBI-3430605|uniprotkb:A0A140SQB4|uniprotkb:A8DY44|uniprotkb:Q2EZ47 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:tra1_drome(display_long)|uniprotkb:Tra1(gene name synonym)|uniprotkb:dTRA1(gene name synonym)|uniprotkb:CG2905(orf name)|uniprotkb:Nipped-A(gene name)|psi-mi:Nipped-A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) ensemblmetazoa:FBgn0053554(gene)|ensemblmetazoa:FBtr0303293(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043486"(histone exchange)|go:"GO:0043966"(histone H3 acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q8I8U7|flybase:FBgn0053554|refseq:NP_001097192.2|refseq:NP_001303335.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:X/Nguxz1x/cqPS3Giq1h0ykXpnQ7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:C9QP01 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4373002|ensemblmetazoa:FBpp0083928 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:c9qp01_drome(display_long)|uniprotkb:CG18428-RA(gene name)|psi-mi:CG18428-RA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) interpro:IPR019532|ensemblmetazoa:FBgn0039149(gene)|ensemblmetazoa:FBtr0084543(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0016607"(nuclear speck) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:ubPfRQzOwMzJNPUXnqV4fZ3h9T47227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:P05661 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-195031|uniprotkb:O18392|uniprotkb:O18393|uniprotkb:Q24412|uniprotkb:Q7JN62|uniprotkb:Q7JN63|uniprotkb:Q7JQ08|uniprotkb:Q7JQ09|uniprotkb:Q7M4K4|uniprotkb:Q8INZ9|uniprotkb:Q8IP00|uniprotkb:Q8IP01|uniprotkb:Q8IP02|uniprotkb:Q8IP03|uniprotkb:Q8IP04|uniprotkb:Q8IP05|uniprotkb:Q8IP06|uniprotkb:Q8IP07|uniprotkb:Q8IP08|uniprotkb:Q8IP09|uniprotkb:Q8IP10|uniprotkb:Q9TY21|uniprotkb:Q9TY22|uniprotkb:Q9TYD7|uniprotkb:Q9VJI3 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:mysa_drome(display_long)|uniprotkb:Mhc(gene name)|psi-mi:Mhc(display_short)|uniprotkb:CG17927(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_001162991.1|refseq:NP_523587.4|refseq:NP_723999.1|refseq:NP_724000.1|refseq:NP_724001.1|refseq:NP_724003.1|refseq:NP_724004.1|refseq:NP_724005.1|refseq:NP_724006.1|refseq:NP_724007.1|refseq:NP_724008.1|refseq:NP_724009.1|refseq:NP_724010.1|refseq:NP_724002.2|flybase:FBgn0264695|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007517"(muscle organ development)|go:"GO:0007527"(adult somatic muscle development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031033"(myosin filament organization)|go:"GO:0031672"(A band)|go:"GO:0040011"(locomotion)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043520"(regulation of myosin II filament assembly)|go:"GO:0045214"(sarcomere organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0060361"(flight)|go:"GO:0071689"(muscle thin filament assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P05661|rcsb pdb:5W1A psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:PjIC1oHiwbQEdum3SDZnk/b7O5E7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9V3K3 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-192924|ensemblmetazoa:FBpp0074756|ensemblmetazoa:FBpp0304236|ensemblmetazoa:FBpp0311247 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:ruvb2_drome(display_long)|uniprotkb:rept(gene name)|psi-mi:rept(display_short)|uniprotkb:CG9750(orf name)|uniprotkb:Dreptin(gene name synonym)|uniprotkb:Reptin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_524156.1|flybase:FBgn0040075|refseq:NP_001287113.1|refseq:NP_001262040.1|ensemblmetazoa:FBgn0040075(gene)|ensemblmetazoa:FBtr0074988(transcript)|ensemblmetazoa:FBtr0331852(transcript)|ensemblmetazoa:FBtr0344993(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:OTelAlg6zQwi3chtx0C/iDKL/607227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9V3E9 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-100795|ensemblmetazoa:FBpp0072164 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q9v3e9_drome(display_long)|uniprotkb:spag(gene name)|psi-mi:spag(display_short)|uniprotkb:Spag(gene name synonym)|uniprotkb:spag-RA(gene name synonym)|uniprotkb:Dmel\CG13570(gene name synonym)|uniprotkb:SPAG(gene name synonym)|uniprotkb:"l(2)k12101"(gene name synonym)|uniprotkb:Rpap3(gene name synonym)|uniprotkb:spagh(gene name synonym)|uniprotkb:CG13570(orf name)|uniprotkb:Dmel_CG13570(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_524664.1|flybase:FBgn0015544|ensemblmetazoa:FBgn0015544(gene)|ensemblmetazoa:FBtr0072256(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:Fwtwtr5edPft4RwbhMCcfSbVrRk7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9VH07 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-234957|intact:EBI-867973|uniprotkb:Q9VH06|uniprotkb:Q9NH53|intact:EBI-234969|ensemblmetazoa:FBpp0081704 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:ruvb1_drome(display_long)|uniprotkb:pont(gene name)|psi-mi:pont(display_short)|uniprotkb:CG4003(orf name)|uniprotkb:Pontin(gene name synonym)|uniprotkb:Dpontin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_652608.1|flybase:FBgn0040078|ensemblmetazoa:FBgn0040078(gene)|ensemblmetazoa:FBtr0082226(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035060"(brahma complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051301"(cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9VH07|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-5696394 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:myRpAnG8tKBHMEnKg+JkpIVkTKg7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q8IN05 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4372700|ensemblmetazoa:FBpp0288790 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q8in05_drome(display_long)|uniprotkb:lqfR(gene name)|psi-mi:lqfR(display_short)|uniprotkb:epsin-like(gene name synonym)|uniprotkb:CG31170(gene name synonym)|uniprotkb:CG31285(gene name synonym)|uniprotkb:CG13853(gene name synonym)|uniprotkb:CG13854(gene name synonym)|uniprotkb:Dmel\CG42250(gene name synonym)|uniprotkb:Epsin(gene name synonym)|uniprotkb:LqfR(gene name synonym)|uniprotkb:Lqfr(gene name synonym)|uniprotkb:Tel2(gene name synonym)|uniprotkb:XII-10(gene name synonym)|uniprotkb:dTel2(gene name synonym)|uniprotkb:epsin(gene name synonym)|uniprotkb:epsin02(gene name synonym)|uniprotkb:epsinR(gene name synonym)|uniprotkb:"l(3)03685"(gene name synonym)|uniprotkb:"l(3)A9"(gene name synonym)|uniprotkb:"l(3)SG62"(gene name synonym)|uniprotkb:"l(3)XII-10"(gene name synonym)|uniprotkb:"l(3)dsl-9"(gene name synonym)|uniprotkb:Dmel_CG42250(orf name)|uniprotkb:"l(3)dsl9"(gene name synonym)|uniprotkb:CG42250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_732736.2|flybase:FBgn0261279|ensemblmetazoa:FBgn0261279(gene)|ensemblmetazoa:FBtr0299516(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR030544|interpro:IPR038528|reactome:R-DME-432722|go:"GO:0006897"(endocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048477"(oogenesis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0098793"(presynapse) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:HfiIkD36Hie9Gv1Bp4YG1cMMaxI7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9VVM7 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-164235|ensemblmetazoa:FBpp0074910 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q9vvm7_drome(display_long)|uniprotkb:Wdr92(gene name)|psi-mi:Wdr92(display_short)|uniprotkb:CG14353-RA(gene name synonym)|uniprotkb:Dmel\CG14353(gene name synonym)|uniprotkb:CG14353(orf name)|uniprotkb:Dmel_CG14353(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373000|imex:IM-15821-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_649025.1|flybase:FBgn0036771|ensemblmetazoa:FBgn0036771(gene)|ensemblmetazoa:FBtr0075144(transcript)|go:"GO:0005955"(calcineurin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:0|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:Hr+3gtLjyXuEvCdJWikuXOQQxHk7227 intact-crc:D41D9139C5961E36|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9V3K3 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-192924|ensemblmetazoa:FBpp0074756|ensemblmetazoa:FBpp0304236|ensemblmetazoa:FBpp0311247 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:ruvb2_drome(display_long)|uniprotkb:rept(gene name)|psi-mi:rept(display_short)|uniprotkb:CG9750(orf name)|uniprotkb:Dreptin(gene name synonym)|uniprotkb:Reptin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_524156.1|flybase:FBgn0040075|refseq:NP_001287113.1|refseq:NP_001262040.1|ensemblmetazoa:FBgn0040075(gene)|ensemblmetazoa:FBtr0074988(transcript)|ensemblmetazoa:FBtr0331852(transcript)|ensemblmetazoa:FBtr0344993(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:OTelAlg6zQwi3chtx0C/iDKL/607227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9V3E9 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-100795|ensemblmetazoa:FBpp0072164 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q9v3e9_drome(display_long)|uniprotkb:spag(gene name)|psi-mi:spag(display_short)|uniprotkb:Spag(gene name synonym)|uniprotkb:spag-RA(gene name synonym)|uniprotkb:Dmel\CG13570(gene name synonym)|uniprotkb:SPAG(gene name synonym)|uniprotkb:"l(2)k12101"(gene name synonym)|uniprotkb:Rpap3(gene name synonym)|uniprotkb:spagh(gene name synonym)|uniprotkb:CG13570(orf name)|uniprotkb:Dmel_CG13570(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_524664.1|flybase:FBgn0015544|ensemblmetazoa:FBgn0015544(gene)|ensemblmetazoa:FBtr0072256(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:Fwtwtr5edPft4RwbhMCcfSbVrRk7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:P05661 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-195031|uniprotkb:O18392|uniprotkb:O18393|uniprotkb:Q24412|uniprotkb:Q7JN62|uniprotkb:Q7JN63|uniprotkb:Q7JQ08|uniprotkb:Q7JQ09|uniprotkb:Q7M4K4|uniprotkb:Q8INZ9|uniprotkb:Q8IP00|uniprotkb:Q8IP01|uniprotkb:Q8IP02|uniprotkb:Q8IP03|uniprotkb:Q8IP04|uniprotkb:Q8IP05|uniprotkb:Q8IP06|uniprotkb:Q8IP07|uniprotkb:Q8IP08|uniprotkb:Q8IP09|uniprotkb:Q8IP10|uniprotkb:Q9TY21|uniprotkb:Q9TY22|uniprotkb:Q9TYD7|uniprotkb:Q9VJI3 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:mysa_drome(display_long)|uniprotkb:Mhc(gene name)|psi-mi:Mhc(display_short)|uniprotkb:CG17927(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_001162991.1|refseq:NP_523587.4|refseq:NP_723999.1|refseq:NP_724000.1|refseq:NP_724001.1|refseq:NP_724003.1|refseq:NP_724004.1|refseq:NP_724005.1|refseq:NP_724006.1|refseq:NP_724007.1|refseq:NP_724008.1|refseq:NP_724009.1|refseq:NP_724010.1|refseq:NP_724002.2|flybase:FBgn0264695|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007517"(muscle organ development)|go:"GO:0007527"(adult somatic muscle development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031033"(myosin filament organization)|go:"GO:0031672"(A band)|go:"GO:0040011"(locomotion)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043520"(regulation of myosin II filament assembly)|go:"GO:0045214"(sarcomere organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0060361"(flight)|go:"GO:0071689"(muscle thin filament assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P05661|rcsb pdb:5W1A psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:PjIC1oHiwbQEdum3SDZnk/b7O5E7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:C9QP01 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4373002|ensemblmetazoa:FBpp0083928 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:c9qp01_drome(display_long)|uniprotkb:CG18428-RA(gene name)|psi-mi:CG18428-RA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) interpro:IPR019532|ensemblmetazoa:FBgn0039149(gene)|ensemblmetazoa:FBtr0084543(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0016607"(nuclear speck) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:ubPfRQzOwMzJNPUXnqV4fZ3h9T47227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9VVM7 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-164235|ensemblmetazoa:FBpp0074910 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q9vvm7_drome(display_long)|uniprotkb:Wdr92(gene name)|psi-mi:Wdr92(display_short)|uniprotkb:CG14353-RA(gene name synonym)|uniprotkb:Dmel\CG14353(gene name synonym)|uniprotkb:CG14353(orf name)|uniprotkb:Dmel_CG14353(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_649025.1|flybase:FBgn0036771|ensemblmetazoa:FBgn0036771(gene)|ensemblmetazoa:FBtr0075144(transcript)|go:"GO:0005955"(calcineurin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:Hr+3gtLjyXuEvCdJWikuXOQQxHk7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q8IN05 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4372700|ensemblmetazoa:FBpp0288790 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:q8in05_drome(display_long)|uniprotkb:lqfR(gene name)|psi-mi:lqfR(display_short)|uniprotkb:epsin-like(gene name synonym)|uniprotkb:CG31170(gene name synonym)|uniprotkb:CG31285(gene name synonym)|uniprotkb:CG13853(gene name synonym)|uniprotkb:CG13854(gene name synonym)|uniprotkb:Dmel\CG42250(gene name synonym)|uniprotkb:Epsin(gene name synonym)|uniprotkb:LqfR(gene name synonym)|uniprotkb:Lqfr(gene name synonym)|uniprotkb:Tel2(gene name synonym)|uniprotkb:XII-10(gene name synonym)|uniprotkb:dTel2(gene name synonym)|uniprotkb:epsin(gene name synonym)|uniprotkb:epsin02(gene name synonym)|uniprotkb:epsinR(gene name synonym)|uniprotkb:"l(3)03685"(gene name synonym)|uniprotkb:"l(3)A9"(gene name synonym)|uniprotkb:"l(3)SG62"(gene name synonym)|uniprotkb:"l(3)XII-10"(gene name synonym)|uniprotkb:"l(3)dsl-9"(gene name synonym)|uniprotkb:Dmel_CG42250(orf name)|uniprotkb:"l(3)dsl9"(gene name synonym)|uniprotkb:CG42250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_732736.2|flybase:FBgn0261279|ensemblmetazoa:FBgn0261279(gene)|ensemblmetazoa:FBtr0299516(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR030544|interpro:IPR038528|reactome:R-DME-432722|go:"GO:0006897"(endocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048477"(oogenesis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0098793"(presynapse) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:HfiIkD36Hie9Gv1Bp4YG1cMMaxI7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:A8JNI2 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-4373007|ensemblmetazoa:FBpp0292226 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:a8jni2_drome(display_long)|uniprotkb:Srrm234(gene name)|psi-mi:Srrm234(display_short)|uniprotkb:"BcDNA:GH04236"(gene name synonym)|uniprotkb:Dmel\CG7971(gene name synonym)|uniprotkb:SRm300(gene name synonym)|uniprotkb:"anon-EST:fe1A7"(gene name synonym)|uniprotkb:CG7971(orf name)|uniprotkb:Dmel_CG7971(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_001097475.2|flybase:FBgn0035253|ensemblmetazoa:FBgn0035253(gene)|ensemblmetazoa:FBtr0303107(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:4KFYjwJgU46h42Yf3KeWMPCsxHA7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q9VH07 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-234957|intact:EBI-867973|uniprotkb:Q9VH06|uniprotkb:Q9NH53|intact:EBI-234969|ensemblmetazoa:FBpp0081704 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:ruvb1_drome(display_long)|uniprotkb:pont(gene name)|psi-mi:pont(display_short)|uniprotkb:CG4003(orf name)|uniprotkb:Pontin(gene name synonym)|uniprotkb:Dpontin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) refseq:NP_652608.1|flybase:FBgn0040078|ensemblmetazoa:FBgn0040078(gene)|ensemblmetazoa:FBtr0082226(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016573"(histone acetylation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035060"(brahma complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043486"(histone exchange)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051301"(cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9VH07|reactome:R-DME-5689603|reactome:R-DME-5689880|reactome:R-DME-5696394 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:myRpAnG8tKBHMEnKg+JkpIVkTKg7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9VH80 uniprotkb:Q8I8U7 intact:EBI-4372717|ensemblmetazoa:FBpp0081644 intact:EBI-2507795|ensemblmetazoa:FBpp0292385|uniprotkb:Q8T3L7|uniprotkb:Q9V9E9|intact:EBI-2549785|intact:EBI-3430605|uniprotkb:A0A140SQB4|uniprotkb:A8DY44|uniprotkb:Q2EZ47 psi-mi:q9vh80_drome(display_long)|uniprotkb:Tti1(gene name)|psi-mi:Tti1(display_short)|uniprotkb:Dmel\CG16908(gene name synonym)|uniprotkb:dTti1(gene name synonym)|uniprotkb:CG16908(orf name)|uniprotkb:Dmel_CG16908(orf name) psi-mi:tra1_drome(display_long)|uniprotkb:Tra1(gene name synonym)|uniprotkb:dTRA1(gene name synonym)|uniprotkb:CG2905(orf name)|uniprotkb:Nipped-A(gene name)|psi-mi:Nipped-A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - imex:IM-15821|pubmed:22068330 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-4373029|imex:IM-15821-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649937.1|flybase:FBgn0037741|ensemblmetazoa:FBgn0037741(gene)|ensemblmetazoa:FBtr0082166(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250) ensemblmetazoa:FBgn0053554(gene)|ensemblmetazoa:FBtr0303293(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043486"(histone exchange)|go:"GO:0043966"(histone H3 acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q8I8U7|flybase:FBgn0053554|refseq:NP_001097192.2|refseq:NP_001303335.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3, Supp. Table 2|variable_condition:100|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-kc167)|taxid:7227(Drosophila melanogaster Kc167 cells) - 2011/08/23 2018/02/26 rogid:9qYa54duc7uYAXR70fS/gs/guN47227 rogid:X/Nguxz1x/cqPS3Giq1h0ykXpnQ7227 intact-crc:9B3B38965E9A694F|rigid:3/LfPx4hYpOBBl4wAXkRUXMjBKs false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)