#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P32455 uniprotkb:P32455 intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504 intact:EBI-2869161|uniprotkb:Q5T8M1|uniprotkb:D3DT26|ensembl:ENSP00000359504 psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym) psi-mi:gbp1_human(display_long)|uniprotkb:GBP1(gene name)|psi-mi:GBP1(display_short)|uniprotkb:GTP-binding protein 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 1(gene name synonym)|uniprotkb:Interferon-induced guanylate-binding protein 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wehner et al. (2012) pubmed:22059445|imex:IM-16720|mint:MINT-8284461|doi:10.1111/j.1742-4658.2011.08415 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7513945|mint:MINT-8284475|imex:IM-16720-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8284477(identity) refseq:NP_002044.2|dip:DIP-60423N|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000117228(gene)|ensembl:ENST00000370473(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005737"(cytoplasm)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|rcsb pdb:1DG3|rcsb pdb:1F5N|rcsb pdb:2B8W|rcsb pdb:2B92|rcsb pdb:2BC9|rcsb pdb:2D4H|rcsb pdb:6K1Z|rcsb pdb:6K2D|rcsb pdb:6LOJ|reactome:R-HSA-877300|go:"GO:0071356"(cellular response to tumor necrosis factor)|mint:MINT-8284477(identity) - comment:"Stoichiometry: 2.0" comment:"Stoichiometry: 2.0" comment:mint|figure legend:f3 t2 st2 sf3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/27 2014/10/16 rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606 rogid:Qjj2KnkVnK0/Er0/5prkVVL6OxY9606 intact-crc:191B5753F73DB0A7|rigid:FldaqeheFk4aC9cHjkG4iQ6UDf0 false mutation disrupting interaction:240-240(MINT-8284859) mutation disrupting interaction:240-240(MINT-8284859) 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)