#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P20909 intact:EBI-5281818 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 - psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:col14a1_bovin_protein(display_short)|psi-mi:EBI-5281818(display_long) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 - psi-mi:"MI:0469"(intact) - comment:Similar to Q05707 figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 - intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q32S24 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281731 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:coba2_bovin(display_long)|uniprotkb:COL11A2(gene name)|psi-mi:COL11A2(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|refseq:NP_001039664.1|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0046872"(metal ion binding) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:BvhYHXrHPF0SF4peZhye3cFiczk9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c sufficient binding region:?-? - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q28083 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281724 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:coba1_bovin(display_long)|uniprotkb:COL11A1(gene name)|psi-mi:COL11A1(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR008160(Collagen triple helix repeat)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:40FISGt8eoNjUHANZBgp5q+OjZ89913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q3SZC6 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282112|ensembl:ENSBTAP00000071807 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:an32b_bovin(display_long)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001030246.1|ensembl:ENSBTAG00000021367(gene)|ensembl:ENSBTAT00000078479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:+aL2sB5TPr7T4lQvxiRsaUOiSpc9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P19858 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282169|uniprotkb:A6H7E0|ensembl:ENSBTAP00000011447|ensembl:ENSBTAP00000047729 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:ldha_bovin(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_776524.1|refseq:XP_005226796.1|ensembl:ENSBTAG00000008683(gene)|ensembl:ENSBTAT00000011447(transcript)|ensembl:ENSBTAT00000056276(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0019752"(carboxylic acid metabolic process)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|reactome:R-BTA-70268 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:kdcUjwM4lDlFugYknZepsEr2hrk9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P60712 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282124|uniprotkb:A5D961|uniprotkb:A5PKA1|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3SZD2|uniprotkb:Q64316|uniprotkb:Q8MIJ0|ensembl:ENSBTAP00000036739 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:actb_bovin(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_776404.2|dip:DIP-57682N|ensembl:ENSBTAG00000026199(gene)|ensembl:ENSBTAT00000036888(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60712|rcsb pdb:1HLU|rcsb pdb:2OAN|rcsb pdb:3U4L|rcsb pdb:3UB5|rcsb pdb:2BTF psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:A5D7D1 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-1221874|ensembl:ENSBTAP00000060553 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:actn4_bovin(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001091521.1|ensembl:ENSBTAG00000011215(gene)|ensembl:ENSBTAT00000086063(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:3f/Bis9sJYLuGGVEimgpsPvb8VE9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q29443 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282153|uniprotkb:Q0IIK2 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:trfe_bovin(display_long)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Siderophilin(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR030685|refseq:NP_803450.2|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|go:"GO:0005615"(extracellular space)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008199"(ferric iron binding) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:N6u577MnPlf17SR5G1pfG61F+EY9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:A6QLL8 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-1221834|ensembl:ENSBTAP00000017177|ensembl:ENSBTAP00000071019 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:a6qll8_bovin(display_long)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001095385.1|refseq:XP_010817708.1|refseq:XP_005224934.1|ensembl:ENSBTAG00000012927(gene)|ensembl:ENSBTAT00000017177(transcript)|ensembl:ENSBTAT00000067155(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0006096"(glycolytic process)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:d12NlX9n7O8ZDz13ib5rfiFCopQ9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q95M18 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282039|uniprotkb:Q3MHX8|ensembl:ENSBTAP00000004364 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:enpl_bovin(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:GRP94(gene name synonym)|uniprotkb:TRA1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_777125.1|ensembl:ENSBTAG00000003362(gene)|ensembl:ENSBTAT00000004364(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|reactome:R-BTA-1679131|reactome:R-BTA-381426|reactome:R-BTA-6785807|reactome:R-BTA-8957275|go:"GO:0003723"(RNA binding) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:2fFvks6eWASn5JCRngmQaBjEEHs9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q0VCX2 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282091|uniprotkb:A7E3V5|ensembl:ENSBTAP00000052422 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:bip_bovin(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001068616.1|dip:DIP-60411N|ensembl:ENSBTAG00000007662(gene)|ensembl:ENSBTAT00000057533(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:LKgBPad+Kw9U8slUc2ZwEw1aTL49913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q29RV1 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282069|uniprotkb:A5D971|uniprotkb:Q0V8E1 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:pdia4_bovin(display_long)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001039344.1|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041866|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042470"(melanosome) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:oXEqoM5elIkPQgTOF0LdO84HA/Y9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:O77588 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5282022|uniprotkb:Q1JPK0 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:plod1_bovin(display_long)|uniprotkb:PLOD1(gene name)|psi-mi:PLOD1(display_short)|uniprotkb:PLOD(gene name synonym)|uniprotkb:Lysyl hydroxylase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|refseq:NP_776573.1|interpro:IPR029044|go:"GO:0005506"(iron ion binding)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:f2FjrYWtK5SJK3mEhVStMjFIxdw9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P38657 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281997 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:pdia3_bovin(display_long)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:GRP58(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041868|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:QItyJ9TH36DyrEC8EYDlUe1ErG89913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:E1B8K6 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281887|ensembl:ENSBTAP00000021529 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:e1b8k6_bovin(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001193589.1|ensembl:ENSBTAG00000016174(gene)|ensembl:ENSBTAT00000021529(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:pnwU5QOQrV023QjuiqjEXZnnmUo9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P46193 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281859|uniprotkb:Q3ZBF5|uniprotkb:Q58DU6 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:anxa1_bovin(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:p35(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_786978.2|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002388(Annexin, type I)|interpro:IPR037104|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:/8HtaQGrBT+kmcPBINxUFJMoLvA9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P52193 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281898|uniprotkb:P28489|uniprotkb:P42918|uniprotkb:Q8SQ53 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:calr_bovin(display_long)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRT(gene name synonym)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_776425.1|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR018124|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR009033(Calreticulin/calnexin, P)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060473"(cortical granule) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:gGZq6Zuz0W6KxQ2sEsRIYU0UWgQ9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P81287 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281922|uniprotkb:Q3ZCH7|uniprotkb:Q5E9B9 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:anxa5_bovin(display_long)|uniprotkb:ANXA5(gene name)|psi-mi:ANXA5(display_short)|uniprotkb:ANX5(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002392(Annexin, type V)|interpro:IPR037104|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0051283"(negative regulation of sequestering of calcium ion) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:MJ4Ukzr/+syZt5zP9h+66piPyTI9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P04272 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281950|uniprotkb:Q3ZCC7|uniprotkb:Q5E9B0|ensembl:ENSBTAP00000012655 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:anxa2_bovin(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:p36(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_777141.1|ensembl:ENSBTAG00000009615(gene)|ensembl:ENSBTAT00000012655(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031982"(vesicle)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046790"(virion binding)|go:"GO:0065010"(extracellular membrane-bounded organelle)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|rcsb pdb:4X9P|reactome:R-BTA-6798695|reactome:R-BTA-75205 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:CiOnnFlfDRaUenwU0XjBa+msLwM9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:F1N401 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281790|ensembl:ENSBTAP00000026725 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:f1n401_bovin(display_long)|uniprotkb:COL12A1(gene name)|psi-mi:COL12A1(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSBTAG00000020056(gene)|ensembl:ENSBTAT00000026725(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0035987"(endodermal cell differentiation)|interpro:IPR001791(Laminin G)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036465 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:rbUyUPRiDtWl63SSlNeokOAIbxY9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P02459 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281315|uniprotkb:Q28070|uniprotkb:Q9XT24|uniprotkb:Q9XT25|ensembl:ENSBTAP00000017505 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:co2a1_bovin(display_long)|uniprotkb:COL2A1(gene name)|psi-mi:COL2A1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_001001135.2|ensembl:ENSBTAG00000013155(gene)|ensembl:ENSBTAT00000017505(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-1442490|reactome:R-BTA-1650814|reactome:R-BTA-2022090|reactome:R-BTA-3000171|reactome:R-BTA-3000178|reactome:R-BTA-8948216 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:DbVTxYXx0hQRDcPXIPiPtwdIJiY9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c sufficient binding region:1242-1487 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P79119 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281223|ensembl:ENSBTAP00000010504 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:epyc_bovin(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:XP_010803061.1|refseq:NP_776732.1|ensembl:ENSBTAG00000007990(gene)|ensembl:ENSBTAT00000010504(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:XE0qgumiEgIkJPCcADOyqK2x54Y9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:F1MER7 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281193|ensembl:ENSBTAP00000022744 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:f1mer7_bovin(display_long)|uniprotkb:HSPG2(gene name)|psi-mi:HSPG2(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSBTAG00000017122(gene)|ensembl:ENSBTAT00000022744(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|interpro:IPR000034(Laminin B)|interpro:IPR000082(SEA)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR023415|interpro:IPR036055|interpro:IPR036179|reactome:R-BTA-1474228|reactome:R-BTA-1971475|reactome:R-BTA-2022928|reactome:R-BTA-2024096|reactome:R-BTA-216083|reactome:R-BTA-3000157 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:KhavqSKYf60OTjMeW5bIpR+7QvE9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:F1MND9 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281339|ensembl:ENSBTAP00000053422 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:f1mnd9_bovin(display_long)|uniprotkb:COL9A1(gene name)|psi-mi:COL9A1(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSBTAG00000035054(gene)|ensembl:ENSBTAT00000061549(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005594"(collagen type IX trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|interpro:IPR008160(Collagen triple helix repeat) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:5xsUtcJrb66TKPyp4idHuMoHz9s9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P35445 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281240|ensembl:ENSBTAP00000006074 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:comp_bovin(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|ensembl:ENSBTAG00000004630(gene)|ensembl:ENSBTAT00000006074(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:3NoFzRvcZkNIQtTLq95IseP/SGs9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:E1BMV3 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281273|ensembl:ENSBTAP00000040771 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:e1bmv3_bovin(display_long)|uniprotkb:MATN1(gene name)|psi-mi:MATN1(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSBTAG00000003479(gene)|ensembl:ENSBTAT00000043181(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR019466|interpro:IPR030751|interpro:IPR036337|interpro:IPR036465|go:"GO:0003429"(growth plate cartilage chondrocyte morphogenesis) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:7UdX5JAlv2499fT9armaQE3v/bA9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:F1MD94 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281261|ensembl:ENSBTAP00000027836 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:f1md94_bovin(display_long)|uniprotkb:MATN3(gene name)|psi-mi:MATN3(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSBTAG00000020893(gene)|ensembl:ENSBTAT00000027836(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030765|interpro:IPR036337|interpro:IPR036465|reactome:R-BTA-381426|reactome:R-BTA-8957275 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:rtKzg+9QyoqEE+qtnxPSZC/Yn0U9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q28178 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281283|uniprotkb:Q28179 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:tsp1_bovin(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP-1(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR026823|interpro:IPR001881(EGF-like calcium-binding)|refseq:NP_776621.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR036383|interpro:IPR028499|interpro:IPR028974|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:QypZlmDOrL2yjpkKOINBnWibtfQ9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P21809 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-2566331|uniprotkb:Q5BIM3|uniprotkb:P79259|uniprotkb:Q17QB0|ensembl:ENSBTAP00000044462 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:pgs1_bovin(display_long)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:Leucine-rich PG I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_847888.2|ensembl:ENSBTAG00000005250(gene)|ensembl:ENSBTAT00000047242(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|rcsb pdb:2FT3|reactome:R-BTA-1971475|reactome:R-BTA-2022870|reactome:R-BTA-2022923|reactome:R-BTA-2024101|reactome:R-BTA-3000178|refseq:XP_005227715.1 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:PGameAxY3dkRrmjf2gLz3I+vUcs9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:P13605 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281124|uniprotkb:A7E3X1|uniprotkb:Q3SWX6|ensembl:ENSBTAP00000019854 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:fmod_bovin(display_long)|uniprotkb:FMOD(gene name)|psi-mi:FMOD(display_short)|uniprotkb:Collagen-binding 59 kDa protein(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan fibromodulin(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 refseq:NP_776483.1|ensembl:ENSBTAG00000014912(gene)|ensembl:ENSBTAT00000019854(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027215|interpro:IPR032675|reactome:R-BTA-2022854|reactome:R-BTA-2022857 psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:S52O/y3SsP4GnuqitcE1ro9C7q89913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q27972 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-5281139 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:chad_bovin(display_long)|uniprotkb:CHAD(gene name)|psi-mi:CHAD(display_short)|uniprotkb:38 kDa bone protein(gene name synonym)|uniprotkb:Cartilage leucine-rich protein(gene name synonym) psi-mi:"MI:0096"(pull down) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-5281033|imex:IM-16591-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 interpro:IPR032675|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|refseq:NP_776444.1|go:"GO:0005576"(extracellular region) psi-mi:"MI:0469"(intact) - - figure legend:TABLE 4 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-cartilage)|taxid:9913(Bos taurus) - 2011/12/08 2019/04/15 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:WccRMXGeqA/z7l8v2tzZyG4Wu+U9913 intact-crc:138EB1BF20E0522C false sufficient binding region:36..36-258..258|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P20909 uniprotkb:Q71SA3 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-2465723 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:q71sa3_rat(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-5282207|imex:IM-16591-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 rgd:1588455|refseq:NP_001013080.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis) go:"GO:0031012"(extracellular matrix) - - figure legend:Fig 7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-chondrosarcoma)|taxid:10116(Rat chondrosarcoma) kd:1.0x10^-7(molar) 2011/12/08 2014/10/16 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:dNQya6QHTyXBcMb7aBwQmhRFJoI10116 intact-crc:7636FC3316373D45|rigid:PerPucwcl0nlSlhav5XNy87ud5k false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P20909 uniprotkb:P07996 intact:EBI-5281039|intact:EBI-5746893|uniprotkb:F1LSI4|uniprotkb:Q62750|uniprotkb:Q63391|uniprotkb:Q63392|uniprotkb:Q63393|uniprotkb:Q8VBY8|uniprotkb:Q920Z7|uniprotkb:Q920Z8|uniprotkb:Q920Z9|uniprotkb:Q921A0|uniprotkb:Q921A1|ensembl:ENSRNOP00000061595 intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99 psi-mi:coba1_rat(display_long)|uniprotkb:Col11a1(gene name)|psi-mi:Col11a1(display_short) psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Brown et al. (2011) pubmed:22038862|imex:IM-16591 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282312|imex:IM-16591-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2372|refseq:XP_006233272.1|refseq:NP_037249.1|ensembl:ENSRNOG00000023148(gene)|ensembl:ENSRNOT00000068413(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035989"(tendon development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051216"(cartilage development)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-RNO-1442490|reactome:R-RNO-1650814|reactome:R-RNO-2022090|reactome:R-RNO-3000171|reactome:R-RNO-8874081|reactome:R-RNO-8948216 ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N psi-mi:"MI:0469"(intact) - - figure legend:Fig 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.0x10^-7(molar) 2011/12/08 2014/10/16 rogid:NcXrSBGu+hHE2E4MKoiXb6lsZM810116 rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606 intact-crc:09524A373FE3CC6A|rigid:w13bhD4vm7nS9mrTKwWaw1l2w6g false sufficient binding region:36-258|his tag:c-c sufficient binding region:19-1170|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)