#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62600	uniprotkb:P62157	intact:EBI-7052018|uniprotkb:Q75NE4|uniprotkb:Q62734|uniprotkb:O88672|intact:MINT-202608|uniprotkb:O89041|uniprotkb:Q68GV6	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:nos3_rat(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0013"(biophysical)	McMurry et al. (2011)	pubmed:22004458|imex:IM-16786|mint:MINT-8205148|doi:10.1111/j.1742-4658.2011.08395	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483704|mint:MINT-8205191|imex:IM-16786-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q62600|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009750"(response to fructose)|go:"GO:0010038"(response to metal ion)|go:"GO:0010181"(FMN binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034097"(response to cytokine)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071000"(response to magnetism)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901556"(response to candesartan)|go:"GO:1901558"(response to metformin)|go:"GO:1901652"(response to peptide)|go:"GO:1901654"(response to ketone)|go:"GO:1902074"(response to salt)|go:"GO:1903576"(response to L-arginine)|go:"GO:1904648"(cellular response to rotenone)|go:"GO:1990478"(response to ultrasound)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-RNO-1222556|reactome:R-RNO-1474151|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-203754|reactome:R-RNO-392154|reactome:R-RNO-5218920|reactome:R-RNO-9009391|rgd:3186|refseq:NP_068610.1|dip:DIP-41833N|mint:MINT-8205197(identity)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P|mint:MINT-8205193(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	-	comment:homomint|comment:mint|figure legend:f1 f2a f3b t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/16	2014/10/16	rogid:GAf5Sj7pV//hAQqxd/xnWwW/C1I10116	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	intact-crc:AE098DDA0BB2AC09|rigid:YLJQvx6KbGmsjh7NcWCEbDUS0sI	false	-	biotin tag:?-?(MINT-8205194)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62600	uniprotkb:P62157	intact:EBI-7052018|uniprotkb:Q75NE4|uniprotkb:Q62734|uniprotkb:O88672|intact:MINT-202608|uniprotkb:O89041|uniprotkb:Q68GV6	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:nos3_rat(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0013"(biophysical)	McMurry et al. (2011)	pubmed:22004458|imex:IM-16786|mint:MINT-8205148|doi:10.1111/j.1742-4658.2011.08395	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483765|mint:MINT-8205719|imex:IM-16786-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q62600|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009750"(response to fructose)|go:"GO:0010038"(response to metal ion)|go:"GO:0010181"(FMN binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034097"(response to cytokine)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071000"(response to magnetism)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901556"(response to candesartan)|go:"GO:1901558"(response to metformin)|go:"GO:1901652"(response to peptide)|go:"GO:1901654"(response to ketone)|go:"GO:1902074"(response to salt)|go:"GO:1903576"(response to L-arginine)|go:"GO:1904648"(cellular response to rotenone)|go:"GO:1990478"(response to ultrasound)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-RNO-1222556|reactome:R-RNO-1474151|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-203754|reactome:R-RNO-392154|reactome:R-RNO-5218920|reactome:R-RNO-9009391|rgd:3186|refseq:NP_068610.1|dip:DIP-41833N|mint:MINT-8205725(identity)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P|mint:MINT-8205721(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/16	2014/10/16	rogid:GAf5Sj7pV//hAQqxd/xnWwW/C1I10116	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	intact-crc:767176D610920C66|rigid:YLJQvx6KbGmsjh7NcWCEbDUS0sI	false	-	biotin tag:?-?(MINT-8205722)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29476	uniprotkb:P62157	intact:EBI-349460|uniprotkb:P70594	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:nos1_rat(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:Bnos(gene name synonym)|uniprotkb:BNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0013"(biophysical)	McMurry et al. (2011)	pubmed:22004458|imex:IM-16786|mint:MINT-8205148|doi:10.1111/j.1742-4658.2011.08395	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483810|mint:MINT-8205733|imex:IM-16786-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_434686.1|rgd:3184|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010288"(response to lead ion)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035094"(response to nicotine)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0070402"(NADPH binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071731"(response to nitric oxide)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1B8Q|rcsb pdb:1CMI|rcsb pdb:1F20|rcsb pdb:1K2R|rcsb pdb:1K2S|rcsb pdb:1K2T|rcsb pdb:1K2U|rcsb pdb:1LZX|rcsb pdb:1LZZ|rcsb pdb:1M00|rcsb pdb:1MMV|interpro:IPR023173|rcsb pdb:1MMW|rcsb pdb:1OM4|rcsb pdb:1OM5|rcsb pdb:1P6H|rcsb pdb:1P6I|rcsb pdb:1P6J|rcsb pdb:1P6K|rcsb pdb:1QAU|rcsb pdb:1QAV|rcsb pdb:1QW6|rcsb pdb:1QWC|rcsb pdb:1RS6|rcsb pdb:1RS7|rcsb pdb:1VAG|rcsb pdb:1ZVI|rcsb pdb:1ZVL|rcsb pdb:1ZZQ|rcsb pdb:1ZZR|rcsb pdb:1ZZU|rcsb pdb:2G6H|rcsb pdb:2G6I|rcsb pdb:2G6J|rcsb pdb:1TLL|rcsb pdb:2G6K|rcsb pdb:2G6L|rcsb pdb:2G6M|rcsb pdb:2G6N|rcsb pdb:2HX3|rcsb pdb:2HX4|rcsb pdb:3B3M|rcsb pdb:3B3N|rcsb pdb:3B3O|rcsb pdb:3B3P|rcsb pdb:3DQR|rcsb pdb:3FC5|rcsb pdb:3HSN|rcsb pdb:3HSO|rcsb pdb:3HSP|rcsb pdb:3JT3|rcsb pdb:3JT4|rcsb pdb:3JT5|rcsb pdb:3JT6|rcsb pdb:3JT7|rcsb pdb:3JT8|rcsb pdb:3N5Y|rcsb pdb:3JT9|rcsb pdb:3JTA|rcsb pdb:3N5Z|rcsb pdb:3N60|rcsb pdb:3N61|rcsb pdb:3N62|rcsb pdb:3N63|rcsb pdb:3N64|rcsb pdb:3N65|rcsb pdb:3N66|rcsb pdb:3JWS|rcsb pdb:3N67|rcsb pdb:3N68|rcsb pdb:3JWT|rcsb pdb:3N69|rcsb pdb:3JWU|rcsb pdb:3JWV|rcsb pdb:3JX0|rcsb pdb:3N6A|rcsb pdb:3N6B|rcsb pdb:3N6C|rcsb pdb:3N6D|rcsb pdb:3N6E|rcsb pdb:3N6F|rcsb pdb:3N6G|rcsb pdb:3NLJ|rcsb pdb:3NLK|rcsb pdb:3NLM|rcsb pdb:3NLN|rcsb pdb:3NLO|rcsb pdb:3NLP|rcsb pdb:3NLQ|rcsb pdb:3NLR|rcsb pdb:3NLV|rcsb pdb:3NLW|rcsb pdb:3NLX|rcsb pdb:3JX1|rcsb pdb:3NLY|rcsb pdb:3NLZ|rcsb pdb:3JX2|rcsb pdb:3JX3|rcsb pdb:3JX4|rcsb pdb:3JX5|rcsb pdb:3JX6|rcsb pdb:3N2R|rcsb pdb:3NM0|rcsb pdb:3NNY|rcsb pdb:3N5V|rcsb pdb:3N5W|rcsb pdb:3N5X|rcsb pdb:3NNZ|rcsb pdb:3PNE|rcsb pdb:3PNF|rcsb pdb:3PNG|rcsb pdb:3Q99|rcsb pdb:3Q9A|rcsb pdb:3RQJ|rcsb pdb:3RQK|rcsb pdb:3RQL|rcsb pdb:3RQM|rcsb pdb:3RQN|rcsb pdb:3SVQ|rcsb pdb:3TYL|rcsb pdb:3TYM|rcsb pdb:3TYN|rcsb pdb:3TYO|rcsb pdb:3UFO|rcsb pdb:3UFP|rcsb pdb:3UFQ|rcsb pdb:3UFR|rcsb pdb:3UFS|rcsb pdb:3UFT|rcsb pdb:3UFU|rcsb pdb:3SVP|rcsb pdb:3UFV|rcsb pdb:3UFW|rcsb pdb:4C39|rcsb pdb:4CAM|rcsb pdb:4CAN|rcsb pdb:4CAO|rcsb pdb:4CAP|rcsb pdb:4CAQ|rcsb pdb:4CDT|rcsb pdb:4CTP|rcsb pdb:4CTQ|rcsb pdb:4CTR|rcsb pdb:4CTT|rcsb pdb:4CTV|rcsb pdb:4CTW|rcsb pdb:4CTX|rcsb pdb:4CX3|rcsb pdb:4CX4|rcsb pdb:4CX5|rcsb pdb:4CX6|rcsb pdb:4D2Y|rcsb pdb:4D2Z|rcsb pdb:4D30|rcsb pdb:4D31|rcsb pdb:4D32|rcsb pdb:4D3B|rcsb pdb:4D7O|rcsb pdb:4EUX|rcsb pdb:4FVW|rcsb pdb:4FVX|rcsb pdb:4FVY|rcsb pdb:4FVZ|rcsb pdb:4FW0|rcsb pdb:4CTU|rcsb pdb:4GQE|rcsb pdb:4HOP|rcsb pdb:4IMS|rcsb pdb:4IMT|rcsb pdb:4IMU|rcsb pdb:4IMW|rcsb pdb:4JSE|rcsb pdb:4JSF|rcsb pdb:4JSG|rcsb pdb:4JSH|rcsb pdb:4JSI|rcsb pdb:4JSJ|rcsb pdb:4K5D|rcsb pdb:4K5E|rcsb pdb:4K5F|rcsb pdb:4K5G|rcsb pdb:4KCH|rcsb pdb:4KCI|rcsb pdb:4KCJ|rcsb pdb:4KCK|rcsb pdb:4KCL|rcsb pdb:4KCM|rcsb pdb:4KCN|rcsb pdb:4KCO|rcsb pdb:4LUX|rcsb pdb:4UGZ|rcsb pdb:4UH0|rcsb pdb:4UH1|rcsb pdb:4UH2|rcsb pdb:4UH3|rcsb pdb:4UH4|rcsb pdb:4UPM|rcsb pdb:4UPN|rcsb pdb:4UPO|rcsb pdb:4UPP|rcsb pdb:4V3V|rcsb pdb:4V3W|rcsb pdb:4V3X|rcsb pdb:4V3Y|rcsb pdb:4V3Z|rcsb pdb:5AD4|rcsb pdb:5AD5|rcsb pdb:5AD6|rcsb pdb:5AD7|rcsb pdb:5AD8|rcsb pdb:5AD9|rcsb pdb:5ADA|rcsb pdb:5ADB|rcsb pdb:5ADC|rcsb pdb:5ADD|rcsb pdb:5ADE|rcsb pdb:5AGK|rcsb pdb:5AGL|rcsb pdb:5AGM|rcsb pdb:5AGN|rcsb pdb:5AGO|rcsb pdb:5AGP|rcsb pdb:5FVO|rcsb pdb:5FVQ|rcsb pdb:5FVP|rcsb pdb:5FVR|rcsb pdb:5FVS|rcsb pdb:5FVT|rcsb pdb:5FW0|rcsb pdb:5G0N|rcsb pdb:5G0O|rcsb pdb:5G0P|rcsb pdb:5UNR|rcsb pdb:5UNS|rcsb pdb:5UNT|rcsb pdb:5UNU|rcsb pdb:5UNV|rcsb pdb:5UNW|rcsb pdb:5UNX|rcsb pdb:5UNY|rcsb pdb:5UNZ|rcsb pdb:5UO0|rcsb pdb:5VUI|rcsb pdb:5VUJ|rcsb pdb:5VUK|rcsb pdb:5VUQ|rcsb pdb:5VUR|rcsb pdb:5VUS|rcsb pdb:5VUT|rcsb pdb:5VUU|rcsb pdb:6AUQ|rcsb pdb:6AUR|rcsb pdb:6AUS|rcsb pdb:6AUT|rcsb pdb:6AUU|rcsb pdb:6AUV|rcsb pdb:6AUW|rcsb pdb:6AUX|rcsb pdb:6NGJ|rcsb pdb:6NGK|rcsb pdb:6NGL|rcsb pdb:6NGM|rcsb pdb:6NGN|rcsb pdb:6NGP|rcsb pdb:5VUL|rcsb pdb:6NGQ|rcsb pdb:6NGR|rcsb pdb:6NGS|rcsb pdb:6NGT|rcsb pdb:6NGU|rcsb pdb:6NGV|rcsb pdb:6NGW|rcsb pdb:6NGX|rcsb pdb:6NGY|rcsb pdb:6NGZ|rcsb pdb:6NH0|rcsb pdb:6NHD|rcsb pdb:5VUM|rcsb pdb:6NHE|rcsb pdb:6PMV|rcsb pdb:6PMW|rcsb pdb:6PMX|rcsb pdb:5VUN|rcsb pdb:5VUO|rcsb pdb:5VUP|rcsb pdb:6PMY|rcsb pdb:6PMZ|rcsb pdb:6PN0|rcsb pdb:6PN1|rcsb pdb:6PN2|rcsb pdb:6PN3|rcsb pdb:6PN4|rcsb pdb:6PN5|rcsb pdb:6PN6|rcsb pdb:6PN7|rcsb pdb:6PN8|rcsb pdb:6PN9|reactome:R-RNO-1222556|reactome:R-RNO-392154|reactome:R-RNO-5578775|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0009725"(response to hormone)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0010181"(FMN binding)|mint:P29476|dip:DIP-33272N|mint:MINT-8205739(identity)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P|mint:MINT-8205735(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/16	2014/10/16	rogid:zTwUJbUZCIUNrueIAbDtZFY04i010116	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	intact-crc:F0BBE8F9865DAB9E|rigid:+kThAO0QT2ciJSM6rJXsK+46FVc	false	-	biotin tag:?-?(MINT-8205736)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)