#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86WV6	uniprotkb:P42226	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237739|imex:IM-16625-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:14B853EA1F5ADB2F|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q7Z434	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237770|imex:IM-16625-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2017/03/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	intact-crc:C4B033739B508FC0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237770|imex:IM-16625-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2017/03/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:C4B033739B508FC0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237770|imex:IM-16625-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2017/03/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:C4B033739B508FC0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q7Z434	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237802|imex:IM-16625-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	intact-crc:9327C8B47BEC1BD0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237802|imex:IM-16625-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:9327C8B47BEC1BD0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237802|imex:IM-16625-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:9327C8B47BEC1BD0|rigid:avmBm6PIjiOHPJ+D7hh6+Swac5A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z434	uniprotkb:Q86WV6	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237922|imex:IM-16625-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4D|comment:TH173 is required for complex formation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:57F1D8812CB1D523|rigid:rxbb629A9zUkkjIGDrnLZnZgd9M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z434	uniprotkb:P42226	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237922|imex:IM-16625-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4D|comment:TH173 is required for complex formation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:57F1D8812CB1D523|rigid:rxbb629A9zUkkjIGDrnLZnZgd9M	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3TBT3	uniprotkb:P52633	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237821|imex:IM-16625-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/10/27	2014/10/16	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090	intact-crc:04D43C5AA24F0BA3|rigid:TkQ8oiwsMh7rT0tsVLuNqL9F3PA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3TBT3	uniprotkb:Q9WUN2	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237821|imex:IM-16625-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/10/27	2014/10/16	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	intact-crc:04D43C5AA24F0BA3|rigid:TkQ8oiwsMh7rT0tsVLuNqL9F3PA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3TBT3	uniprotkb:P52633	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237827|imex:IM-16625-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/10/27	2014/10/16	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090	intact-crc:04D3519AA24F0BA3|rigid:TkQ8oiwsMh7rT0tsVLuNqL9F3PA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3TBT3	uniprotkb:Q9WUN2	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237827|imex:IM-16625-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/10/27	2014/10/16	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	intact-crc:04D3519AA24F0BA3|rigid:TkQ8oiwsMh7rT0tsVLuNqL9F3PA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237575|imex:IM-16625-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:5B19E48DF8F729EF|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	-	sufficient binding region:178-379	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237795|imex:IM-16625-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:0E3F5D0EE380EC16|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237846|imex:IM-16625-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-2ftgh)|taxid:9606(Human 2fTGH cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:8EEE31403D966A6F|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237846|imex:IM-16625-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-2ftgh)|taxid:9606(Human 2fTGH cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:8EEE31403D966A6F|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237854|imex:IM-16625-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-2ftgh)|taxid:9606(Human 2fTGH cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:DEAA31403D966A68|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237854|imex:IM-16625-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-2ftgh)|taxid:9606(Human 2fTGH cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:DEAA31403D966A68|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237871|imex:IM-16625-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:BEB8AE583542964E|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237871|imex:IM-16625-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:BEB8AE583542964E|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237874|imex:IM-16625-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:EEFCAE5835429649|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:Q9UHD2	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237874|imex:IM-16625-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|variable_condition:6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:EEFCAE5835429649|rigid:GyuBzh5G5I3lgwpsdT6pFeHZLbE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42226	uniprotkb:P42226	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237904|imex:IM-16625-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig 2N|agonist:Sendai virus infection|comment:Leu551Ala prevents viral-induced dimerization but has no effect on that induced by IL-4.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:AB0913B9C00ED568|rigid:ZKus9BBAKXUkRxCaGkdhALQMC6g	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14653	uniprotkb:Q14653	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237909|imex:IM-16625-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp Fig. 2N|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	intact-crc:71AC05032337CF06|rigid:y/wjSxLhOsf5dKzciLRCT0YH2Ho	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHD2	uniprotkb:P42226	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5238175|imex:IM-16625-18	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	comment:Phosphorylation of peptide STAT6 358–427 was greatly impaired in Ser407Ala was mutated.|resulting-ptm:Phosphorylation of Ser-407|figure legend:Fig. 6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/27	2014/10/16	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:D6B7EABB28CE0B91|rigid:WLCWYf6/4c8eVNl4jmgogtTGMb8	false	flag tag:?-?	sufficient binding region:610-847|mutation:407-407|sufficient binding region:358-427	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86WV6	uniprotkb:P42226	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237600|imex:IM-16625-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 2A, 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:C948374126E116DC|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	ha tag:?-?	necessary binding region:260-430|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42226	uniprotkb:Q86WV6	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237639|imex:IM-16625-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	psi-mi:"MI:0469"(intact)	-	-	figure legend:SUpp. Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:169B8F057EEBC701|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	flag tag:?-?	ha tag:?-?|sufficient binding region:317-379	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:P42226	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237624|imex:IM-16625-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:5C73145DDB0065E9|rigid:h2S3AtRXtMm1IJyiS8rBcGHtGic	false	ha tag:?-?	necessary binding region:260-430|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42226	uniprotkb:P42226	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:22000020|imex:IM-16625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5237887|imex:IM-16625-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 2M|agonist:Sendai virus infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/27	2014/10/16	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606	intact-crc:96478ADA751210DD|rigid:hRaobDcuNdVjAyA/pn+0qhmzEMI	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)