#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:45006"	uniprotkb:P48542	intact:EBI-5236801	intact:EBI-5236710|uniprotkb:O70290|uniprotkb:P70216|uniprotkb:P70306|uniprotkb:P70307|uniprotkb:P70308|uniprotkb:P70309|uniprotkb:P70454|uniprotkb:Q9QYH5	psi-mi:pip2-octanoylglyceryl(display_short)|psi-mi:"CHEBI:45006"(display_long)	psi-mi:kcnj6_mouse(display_long)|uniprotkb:Kcnj6(gene name)|psi-mi:Kcnj6(display_short)|uniprotkb:Girk2(gene name synonym)|uniprotkb:Kcnj7(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir3.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 6(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Whorton et al. (2011)	pubmed:21962516|imex:IM-16624	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5236788|imex:IM-16624-2|wwpdb:3SYA	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001020756.1|refseq:NP_034736.2|dip:DIP-60215N|reactome:R-MMU-1296041|reactome:R-MMU-997272|refseq:XP_011244406.1|refseq:NP_001020761.1|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015467"(G-protein activated inward rectifier potassium channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003275(Potassium channel, inwardly rectifying, Kir3.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:2E4F|rcsb pdb:3AGW|rcsb pdb:3AT8|rcsb pdb:3AT9|rcsb pdb:3ATA|rcsb pdb:3ATB|rcsb pdb:3ATD|rcsb pdb:3ATE|rcsb pdb:3ATF|rcsb pdb:3AUW|rcsb pdb:3SYA|rcsb pdb:3SYC|rcsb pdb:3SYO|rcsb pdb:3SYP|rcsb pdb:3SYQ|rcsb pdb:3VSQ|rcsb pdb:4KFM|rcsb pdb:6XIS|rcsb pdb:6XIT	-	-	-	figure legend:Supp. Table 1|3d-resolution:3.0A|3d-r-factors:Rworking = 24% Rfree =  26.92%|3d-structure:"G proteins open a G loop gate in the cytoplasmic domain in the presence of PIP2. An Arg201ala mutant also crystallised as a tetramer (3SYQ). This shows a large change in both the G loop and the inner helix gates in comparison to wild tye and only two of the four subunits are free to bind PIP2 and undergo the conformational change"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/26	2014/10/16	-	rogid:asQ42ag5O0IwlDmhDoCl+QUyeXM10090	intact-crc:381A1058B94EDF5F	false	-	sufficient binding region:52-380	1	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48542	uniprotkb:P48542	intact:EBI-5236710|uniprotkb:O70290|uniprotkb:P70216|uniprotkb:P70306|uniprotkb:P70307|uniprotkb:P70308|uniprotkb:P70309|uniprotkb:P70454|uniprotkb:Q9QYH5	intact:EBI-5236710|uniprotkb:O70290|uniprotkb:P70216|uniprotkb:P70306|uniprotkb:P70307|uniprotkb:P70308|uniprotkb:P70309|uniprotkb:P70454|uniprotkb:Q9QYH5	psi-mi:kcnj6_mouse(display_long)|uniprotkb:Kcnj6(gene name)|psi-mi:Kcnj6(display_short)|uniprotkb:Girk2(gene name synonym)|uniprotkb:Kcnj7(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir3.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 6(gene name synonym)	psi-mi:kcnj6_mouse(display_long)|uniprotkb:Kcnj6(gene name)|psi-mi:Kcnj6(display_short)|uniprotkb:Girk2(gene name synonym)|uniprotkb:Kcnj7(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir3.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 6(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Whorton et al. (2011)	pubmed:21962516|imex:IM-16624	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5236709|wwpdb:3SYO|imex:IM-16624-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020756.1|refseq:NP_034736.2|dip:DIP-60215N|reactome:R-MMU-1296041|reactome:R-MMU-997272|refseq:XP_011244406.1|refseq:NP_001020761.1|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015467"(G-protein activated inward rectifier potassium channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003275(Potassium channel, inwardly rectifying, Kir3.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:2E4F|rcsb pdb:3AGW|rcsb pdb:3AT8|rcsb pdb:3AT9|rcsb pdb:3ATA|rcsb pdb:3ATB|rcsb pdb:3ATD|rcsb pdb:3ATE|rcsb pdb:3ATF|rcsb pdb:3AUW|rcsb pdb:3SYA|rcsb pdb:3SYC|rcsb pdb:3SYO|rcsb pdb:3SYP|rcsb pdb:3SYQ|rcsb pdb:3VSQ|rcsb pdb:4KFM|rcsb pdb:6XIS|rcsb pdb:6XIT	refseq:NP_001020756.1|refseq:NP_034736.2|dip:DIP-60215N|reactome:R-MMU-1296041|reactome:R-MMU-997272|refseq:XP_011244406.1|refseq:NP_001020761.1|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015467"(G-protein activated inward rectifier potassium channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003275(Potassium channel, inwardly rectifying, Kir3.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:2E4F|rcsb pdb:3AGW|rcsb pdb:3AT8|rcsb pdb:3AT9|rcsb pdb:3ATA|rcsb pdb:3ATB|rcsb pdb:3ATD|rcsb pdb:3ATE|rcsb pdb:3ATF|rcsb pdb:3AUW|rcsb pdb:3SYA|rcsb pdb:3SYC|rcsb pdb:3SYO|rcsb pdb:3SYP|rcsb pdb:3SYQ|rcsb pdb:3VSQ|rcsb pdb:4KFM|rcsb pdb:6XIS|rcsb pdb:6XIT	-	-	-	figure legend:Supp. Table 1|3d-resolution:3.5A|3d-r-factors:Rworking = 26% Rfree =  27.27%|comment:"An Arg201ala mutant also crystallised as a tetramer (3SYC)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/26	2014/10/16	rogid:asQ42ag5O0IwlDmhDoCl+QUyeXM10090	rogid:asQ42ag5O0IwlDmhDoCl+QUyeXM10090	intact-crc:EF2EBAC7C2037A28|rigid:C73267YZhBOIwnbWez5W9EJf5eI	false	sufficient binding region:52-380	sufficient binding region:52-380	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)