#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ULQ1	uniprotkb:Q9ULQ1	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239894|imex:IM-17031-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:2E45619DD28FF1A5|rigid:gKCF9lj0UB54UwI4CdAPGHi40/A	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULQ1	uniprotkb:Q9ULQ1	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239925|imex:IM-17031-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:4332CDF9DFAA33CA|rigid:gKCF9lj0UB54UwI4CdAPGHi40/A	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NHX9	uniprotkb:Q8NHX9	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239948|imex:IM-17031-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:CAB03A16C4E11144|rigid:0PkeBhmUqstHj0l7h2YpG6ojv+g	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NHX9	uniprotkb:Q8NHX9	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239974|imex:IM-17031-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:1501D0519090820B|rigid:0PkeBhmUqstHj0l7h2YpG6ojv+g	false	ha tag:?-?	fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NHX9	uniprotkb:Q9ULQ1	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239991|imex:IM-17031-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:190EE766421170AF|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5239999|imex:IM-17031-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:687EB011D60A4387|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NHX9	uniprotkb:Q9ULQ1	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240060|imex:IM-17031-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	go:"GO:0031982"(vesicle)	-	-	figure legend:SUpp. Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:9D98902CB8A41E7E|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q8NHX9	uniprotkb:Q9ULQ1	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240152|imex:IM-17031-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	go:"GO:0031982"(vesicle)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:F6076788D7094C3C|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	ha tag:?-?	fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240130|imex:IM-17031-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:106DCB3C20284A07|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240146|imex:IM-17031-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:6CA6A667AF70D965|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	-	ha tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240008|imex:IM-17031-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:B6D730910862B5CF|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	ha tag:?-?	fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240016|imex:IM-17031-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:C7A767E69C7986E7|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULQ1	uniprotkb:Q9ULQ1	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240087|imex:IM-17031-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:B7AE89CB08091D48|rigid:gKCF9lj0UB54UwI4CdAPGHi40/A	false	cyan fluorescent protein tag:?-?	yellow fluorescent protein tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9ULQ1	uniprotkb:Q8NHX9	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240113|imex:IM-17031-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:E57AE632E18D7B3F|rigid:pwnRCcBWWgD9MHEDKj3ONCGbmfY	false	yellow fluorescent protein tag:n-n	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q8NHX9	uniprotkb:Q8NHX9	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240103|imex:IM-17031-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:D3F9AE6ADC1563F3|rigid:0PkeBhmUqstHj0l7h2YpG6ojv+g	false	cyan fluorescent protein tag:n-n	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q8NHX9	uniprotkb:Q8NHX9	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rietdorf et al. (2011)	pubmed:21903581|imex:IM-17031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5240095|imex:IM-17031-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/01	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:1505816953016D43|rigid:0PkeBhmUqstHj0l7h2YpG6ojv+g	false	yellow fluorescent protein tag:n-n	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)