#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35956	uniprotkb:O35956	intact:EBI-5261328|ensembl:ENSRNOP00000024756	intact:EBI-5261328|ensembl:ENSRNOP00000024756	psi-mi:s22a6_rat(display_long)|uniprotkb:Slc22a6(gene name)|psi-mi:Slc22a6(display_short)|uniprotkb:Oat1(gene name synonym)|uniprotkb:Organic anion transporter 1(gene name synonym)|uniprotkb:renal organic anion transporter 1(gene name synonym)	psi-mi:s22a6_rat(display_long)|uniprotkb:Slc22a6(gene name)|psi-mi:Slc22a6(display_short)|uniprotkb:Oat1(gene name synonym)|uniprotkb:Organic anion transporter 1(gene name synonym)|uniprotkb:renal organic anion transporter 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5277626|imex:IM-16936-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69338|refseq:NP_058920.1|ensembl:ENSRNOG00000018215(gene)|ensembl:ENSRNOT00000024757(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006820"(anion transport)|go:"GO:0008514"(organic anion transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015347"(sodium-independent organic anion transmembrane transporter activity)|go:"GO:0015711"(organic anion transport)|go:"GO:0015742"(alpha-ketoglutarate transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031404"(chloride ion binding)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043252"(sodium-independent organic anion transport)|go:"GO:0097254"(renal tubular secretion)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-561048	rgd:69338|refseq:NP_058920.1|ensembl:ENSRNOG00000018215(gene)|ensembl:ENSRNOT00000024757(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006820"(anion transport)|go:"GO:0008514"(organic anion transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015347"(sodium-independent organic anion transmembrane transporter activity)|go:"GO:0015711"(organic anion transport)|go:"GO:0015742"(alpha-ketoglutarate transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031404"(chloride ion binding)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043252"(sodium-independent organic anion transport)|go:"GO:0097254"(renal tubular secretion)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-561048	-	-	-	comment:Nmers eluting in the void volumeobserved in the presence of CHAPS and LMPG extract.|inhibition:DTT|figure legend:supplemental fig. 1|comment:The complex eluted in the void volume indicating a n-nary complex that was not resolved as dimer or tetramer on the sephadex 200 column.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:TUObGlvoLZXul86FI3fJ5aRGuRg10116	rogid:TUObGlvoLZXul86FI3fJ5aRGuRg10116	intact-crc:EF78AB0377BBB61C|rigid:ueXSpVSbrudxCpy1czx3w2QP2Vs	false	-	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q63089	uniprotkb:Q63089	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5262064|imex:IM-16936-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:4|inhibition:DTT|comment:Dimers observed in the presence of CHAP and tetramers in the presence of CHAPS and LMPG extract.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:2E25901C962BD8B9|rigid:ZvJo3dwx5bl9O3kPAe/pVwasxc4	false	tag:?-?	tag:?-?	4	0	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q63089	uniprotkb:Q63089	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261934|imex:IM-16936-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:4|inhibition:DTT|comment:Dimers observed in the presence of CHAP and tetramers int he presence of CHAPS and LMPG extract.|comment:Monomers of Oct1 comigrated with 75kda while dimers comigrated at 158 KDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:BAB3B293432299C8|rigid:ZvJo3dwx5bl9O3kPAe/pVwasxc4	false	tag:?-?	tag:?-?	2	0	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q63089	uniprotkb:O35956	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	intact:EBI-5261328|ensembl:ENSRNOP00000024756	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:s22a6_rat(display_long)|uniprotkb:Slc22a6(gene name)|psi-mi:Slc22a6(display_short)|uniprotkb:Oat1(gene name synonym)|uniprotkb:Organic anion transporter 1(gene name synonym)|uniprotkb:renal organic anion transporter 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261319|imex:IM-16936-2	author score:12.3	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	rgd:69338|refseq:NP_058920.1|ensembl:ENSRNOG00000018215(gene)|ensembl:ENSRNOT00000024757(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006820"(anion transport)|go:"GO:0008514"(organic anion transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015347"(sodium-independent organic anion transmembrane transporter activity)|go:"GO:0015711"(organic anion transport)|go:"GO:0015742"(alpha-ketoglutarate transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031404"(chloride ion binding)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043252"(sodium-independent organic anion transport)|go:"GO:0097254"(renal tubular secretion)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-561048	-	-	-	comment:rOct1-rOct1 93.3%|figure legend:fig 2, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	rogid:TUObGlvoLZXul86FI3fJ5aRGuRg10116	intact-crc:DC6E9A5D6CFB127C|rigid:8aYGbS9qG0r5CBKzrLfpYf3mNAA	false	mutation:163-163,159-159|his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-5261357	uniprotkb:Q63089	-	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261361|imex:IM-16936-3	author score:10.7	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:fig 2, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:21C53971F41A6B34|rigid:EhCk7EHkI99bsuLQK8EE/NE0NUA	false	his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35956	intact:EBI-5261357	intact:EBI-5261328|ensembl:ENSRNOP00000024756	-	psi-mi:s22a6_rat(display_long)|uniprotkb:Slc22a6(gene name)|psi-mi:Slc22a6(display_short)|uniprotkb:Oat1(gene name synonym)|uniprotkb:Organic anion transporter 1(gene name synonym)|uniprotkb:renal organic anion transporter 1(gene name synonym)	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:"MI:0096"(pull down)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261373|imex:IM-16936-4	author score:58.3	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69338|refseq:NP_058920.1|ensembl:ENSRNOG00000018215(gene)|ensembl:ENSRNOT00000024757(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006820"(anion transport)|go:"GO:0008514"(organic anion transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015347"(sodium-independent organic anion transmembrane transporter activity)|go:"GO:0015711"(organic anion transport)|go:"GO:0015742"(alpha-ketoglutarate transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031404"(chloride ion binding)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043252"(sodium-independent organic anion transport)|go:"GO:0097254"(renal tubular secretion)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-561048	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	-	-	-	figure legend:fig 2, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:TUObGlvoLZXul86FI3fJ5aRGuRg10116	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	intact-crc:0CCFA370D52FFF8E|rigid:DjM7RhZQe8IJG7yrOyFn6FpFXTI	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63089	uniprotkb:Q63089	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261182|imex:IM-16936-1	author score:93.3	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:fig 1, fig 3a,  table 1|comment:21.7 % of FLAG protein binding of the 6 cys to ser mutant construct observed. 86.3 % of FLAG protein binding of L447Y/Q448E mutant construct observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:A323308A818B9EB4|rigid:KSrWctdz44AB8Bo+a+18WpuYKR0	false	flag tag:?-?|mutation decreasing interaction:143-143,122-122,103-103,89-89,62-62,50-50	his tag:?-?|mutation decreasing interaction:50-50,62-62,89-89,103-103,122-122,143-143	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-5261357	intact:EBI-5261357	-	-	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:"MI:0096"(pull down)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5261383|imex:IM-16936-5	author score:61.0	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	-	-	-	figure legend:fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/16	2014/10/16	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	intact-crc:6E486C98524F3767|rigid:aXiF7vBACZTryD3vcYWaFirzku8	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-5261357	intact:EBI-5261357	-	-	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5266818|imex:IM-16936-7	author score:61.0	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	-	-	-	figure legend:7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/11/16	2014/10/16	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	intact-crc:1C835F8FD372E70B|rigid:aXiF7vBACZTryD3vcYWaFirzku8	false	yellow fluorescent protein tag:?-?	cyan fluorescent protein tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q63089	uniprotkb:Q63089	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5266768|imex:IM-16936-6	author score:93.3	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:7,8|comment:21.7 % of FLAG protein binding of the 6 cys to ser mutant construct observed. 86.3 % of FLAG protein binding of L447Y/Q448E mutant construct observed.|inhibition:DTT|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/11/16	2014/10/16	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:E8E9F4BECC4A3036|rigid:KSrWctdz44AB8Bo+a+18WpuYKR0	false	yellow fluorescent protein tag:?-?|mutation decreasing interaction:50-50,61-61,89-89,103-103,122-122,143-143	cyan fluorescent protein tag:?-?|mutation decreasing interaction:143-143,122-122,103-103,89-89,62-62,50-50	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:641"	uniprotkb:Q63089	intact:EBI-5262291	intact:EBI-5261153|uniprotkb:O35882|uniprotkb:Q6AYW1|ensembl:ENSRNOP00000022254	psi-mi:mpp(display_short)|psi-mi:"CHEBI:641"(display_long)	psi-mi:s22a1_rat(display_long)|uniprotkb:Slc22a1(gene name)|psi-mi:Slc22a1(display_short)|uniprotkb:Oct1(gene name synonym)|uniprotkb:Organic cation transporter 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5267083|imex:IM-16936-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:3224|refseq:NP_036829.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0048241"(epinephrine transport)|go:"GO:0051610"(serotonin uptake)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098793"(presynapse)|go:"GO:1901998"(toxin transport)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-112311|reactome:R-RNO-181430|reactome:R-RNO-2161517|reactome:R-RNO-442660|reactome:R-RNO-549127|ensembl:ENSRNOT00000022254(transcript)|go:"GO:0005277"(acetylcholine transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0008513"(secondary active organic cation transmembrane transporter activity)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0015101"(organic cation transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015695"(organic cation transport)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019534"(toxin transmembrane transporter activity)|ensembl:ENSRNOG00000016337(gene)	-	-	-	figure legend:Figs. 5, 6 table 2|kinetic_conditions:rOct1 Turnover=19.5, Km =3.5E-5, Inhibition IC50 in presence of TEA Km=1.5E-4, TBuA Km=1.8E-5, TPeA Km=2.8E-6. roct 6cystoser mutation Turnover=9.1, Km =1.0E-4, Inhibition IC50 in presence of TEA Km=1.8E-4, TBuA Km=2.7E-5, TPeA Km=3.7E-6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-4(molar)	2011/11/16	2014/10/16	-	rogid:/NgjkDrW7r8CgPD34UOBfBfKG0A10116	intact-crc:11300D979038AE93	false	3h radiolabel:?-?	mutation decreasing interaction:61-61,89-89,103-103,122-122,143-143,50-50	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:641"	intact:EBI-5261357	intact:EBI-5262291	-	psi-mi:mpp(display_short)|psi-mi:"CHEBI:641"(display_long)	psi-mi:oct1_oat1(display_short)|psi-mi:EBI-5261357(display_long)	psi-mi:"MI:0071"(molecular sieving)	Keller et al. (2011)	pubmed:21896487|imex:IM-16936|mint:MINT-8292302	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5266255|imex:IM-16936-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:O35956(multiple parent)|uniprotkb:Q63089(multiple parent)	-	-	-	figure legend:Figs. 5, 6 table 2|kinetic_conditions:"rOct1(Oat1-l) Turnover=8.2, Km =1.1E-4, Inhibition IC50 in presence of TEA Km=1.7E-4, TBuA Km=2.5E-5, TPeA Km=3.6E-6"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-4(molar)	2011/11/16	2014/10/16	-	rogid:35N8/fO6IKyGePFSn8mpDSbu0Qc10116	intact-crc:62AB97ABAAAC541F	false	3h radiolabel:?-?	tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)