#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JJF9	uniprotkb:P13473	intact:EBI-7091975|ensembl:ENSMUSP00000028844|uniprotkb:A2AI51|intact:UNK-5549237|uniprotkb:Q8R354	intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639	psi-mi:spp2a_mouse(display_long)|uniprotkb:Sppl2a(gene name)|psi-mi:Sppl2a(display_short)|uniprotkb:Psl2(gene name synonym)|uniprotkb:MNCb-3763(orf name)|uniprotkb:Imp3(gene name synonym)|uniprotkb:Intramembrane protease 3(gene name synonym)|uniprotkb:Presenilin-like protein 2(gene name synonym)	psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Behnke et al. (2011)	pubmed:21896273|imex:IM-16779|mint:MINT-8203197|doi:10.1016/j.febslet.2011.08.043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7092018|mint:MINT-8203202|imex:IM-16779-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238039.1|ensembl:ENSMUSG00000027366(gene)|ensembl:ENSMUST00000028844(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR003137(Protease-associated PA)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-MMU-5357905|refseq:NP_075709.2|mint:MINT-8203205(identity)	refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829|mint:MINT-8203204(identity)	go:"GO:0005770"(late endosome)|go:"GO:0005764"(lysosome)	comment:mint|function:May act as intramembrane protease	-	comment:homomint|comment:mint|figure legend:f1b f2b f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/08/30	2018/05/16	rogid:cdfFix95pwJlevRAt2srSyvrur810090	rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606	intact-crc:62A738B9BCDC5C1B|rigid:EObMfGR0orm/Ex0Bx3RXpa9rb0I	false	myc tag:?-?(MINT-8203212)|mutation disrupting interaction:498-498(MINT-8203218)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJF9	uniprotkb:P13473	intact:EBI-7091975|ensembl:ENSMUSP00000028844|uniprotkb:A2AI51|intact:UNK-5549237|uniprotkb:Q8R354	intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639	psi-mi:spp2a_mouse(display_long)|uniprotkb:Sppl2a(gene name)|psi-mi:Sppl2a(display_short)|uniprotkb:Psl2(gene name synonym)|uniprotkb:MNCb-3763(orf name)|uniprotkb:Imp3(gene name synonym)|uniprotkb:Intramembrane protease 3(gene name synonym)|uniprotkb:Presenilin-like protein 2(gene name synonym)	psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Behnke et al. (2011)	pubmed:21896273|imex:IM-16779|mint:MINT-8203197|doi:10.1016/j.febslet.2011.08.043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7092098|mint:MINT-8203222|imex:IM-16779-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238039.1|ensembl:ENSMUSG00000027366(gene)|ensembl:ENSMUST00000028844(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR003137(Protease-associated PA)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-MMU-5357905|refseq:NP_075709.2|mint:MINT-8203227(identity)	refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829|mint:MINT-8203225(identity)	go:"GO:0005770"(late endosome)|go:"GO:0005764"(lysosome)	comment:mint|function:May act as intramembrane protease	-	comment:homomint|comment:mint|figure legend:f1b f2b f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/08/30	2014/10/16	rogid:cdfFix95pwJlevRAt2srSyvrur810090	rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606	intact-crc:1823B15947A05AAA|rigid:EObMfGR0orm/Ex0Bx3RXpa9rb0I	false	myc tag:?-?(MINT-8203230)|mutation disrupting interaction:506-506(MINT-8203234)|mutation disrupting interaction:498-498(MINT-8203228)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJF9	uniprotkb:P17047	intact:EBI-7091975|ensembl:ENSMUSP00000028844|uniprotkb:A2AI51|intact:UNK-5549237|uniprotkb:Q8R354	intact:EBI-1564749|uniprotkb:A2A430|uniprotkb:Q3TXG5|uniprotkb:Q8BSG8|ensembl:ENSMUSP00000016678	psi-mi:spp2a_mouse(display_long)|uniprotkb:Sppl2a(gene name)|psi-mi:Sppl2a(display_short)|uniprotkb:Psl2(gene name synonym)|uniprotkb:MNCb-3763(orf name)|uniprotkb:Imp3(gene name synonym)|uniprotkb:Intramembrane protease 3(gene name synonym)|uniprotkb:Presenilin-like protein 2(gene name synonym)	psi-mi:lamp2_mouse(display_long)|uniprotkb:Lysosomal membrane glycoprotein type B(gene name synonym)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:Lamp2(gene name)|psi-mi:Lamp2(display_short)|uniprotkb:Lamp-2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Behnke et al. (2011)	pubmed:21896273|imex:IM-16779|mint:MINT-8203197|doi:10.1016/j.febslet.2011.08.043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7092149|mint:MINT-8203238|imex:IM-16779-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238039.1|ensembl:ENSMUSG00000027366(gene)|ensembl:ENSMUST00000028844(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR003137(Protease-associated PA)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-MMU-5357905|refseq:NP_075709.2|mint:MINT-8203243(identity)	refseq:NP_001017959.1|refseq:NP_034815.2|ensembl:ENSMUSG00000016534(gene)|ensembl:ENSMUST00000016678(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0044754"(autolysosome)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P17047|rcsb pdb:5GV3|reactome:R-MMU-114608|reactome:R-MMU-6798695|mint:MINT-8203241(identity)	go:"GO:0005770"(late endosome)|go:"GO:0005764"(lysosome)	comment:mint|function:May act as intramembrane protease	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/08/30	2014/10/16	rogid:cdfFix95pwJlevRAt2srSyvrur810090	rogid:em1v9qxpoHR13ocQdAffj+zQSDE10090	intact-crc:0080916208E023EC|rigid:vB72qZghJWKBch7M0jJI0OwHOeI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)