#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9EP73 uniprotkb:Q02242 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258903|ensembl:ENSMUSP00000027507 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_mouse(display_long)|uniprotkb:Pdcd1(gene name)|psi-mi:Pdcd1(display_short)|uniprotkb:Pd1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258901|imex:IM-16599-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_032824.1|dip:DIP-29730N|ensembl:ENSMUSG00000026285(gene)|ensembl:ENSMUST00000027507(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002644"(negative regulation of tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|rcsb pdb:1NPU|rcsb pdb:3BIK|rcsb pdb:3BP5|rcsb pdb:3BP6|rcsb pdb:3RNK|rcsb pdb:3RNQ|rcsb pdb:3SBW|reactome:R-MMU-389948 psi-mi:"MI:0469"(intact) - - figure legend:fig. 7a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.2x10^-7(molar) 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:uMdviLCRVTa0x+xPdJW0k0MkdVQ10090 intact-crc:351AFDF54506BEF3|rigid:HEvitUQF5EurjTq1e3nVzphMtJw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9EP73 uniprotkb:Q00609 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258953|imex:IM-16599-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0469"(intact) - - figure legend:fig. 7b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.8x10^-7(molar) 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 intact-crc:FA65926DFB50DFC3|rigid:DqLWup3ULbHq5WNZXysLpJkx1T4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9EP73 uniprotkb:Q00609 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258958|imex:IM-16599-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0469"(intact) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.1x10^-6(molar) 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 intact-crc:361A526AC4135F2F|rigid:DqLWup3ULbHq5WNZXysLpJkx1T4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00609 uniprotkb:Q00609 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258969|imex:IM-16599-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0469"(intact) - - figure legend:fig. 9a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/11/10 2014/10/16 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 intact-crc:B96CF727DD638319|rigid:Lf0gxfx/61dKV/KSHQqODV0xKbk false fusion protein:?-? fusion protein:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9EP73 uniprotkb:Q9EP73 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258879|ensembl:ENSMUSP00000016640 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258977|imex:IM-16599-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) psi-mi:"MI:0469"(intact) - - figure legend:fig. 9b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 intact-crc:87C36FDBC0B40213|rigid:SlEfX6wmtQbqLNWPTKaa07YVwyg false fusion protein:?-? fusion protein:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9EP73 uniprotkb:Q00609 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258985|imex:IM-16599-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0469"(intact) - - figure legend:fig.9a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 intact-crc:AE38EB7F299CC1DD|rigid:DqLWup3ULbHq5WNZXysLpJkx1T4 false fusion protein:?-? fusion protein:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9EP73 uniprotkb:Q00609 intact:EBI-5258879|ensembl:ENSMUSP00000016640 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Grellier et al. (2011) pubmed:21884581|imex:IM-16599 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-5258993|imex:IM-16599-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0469"(intact) - - figure legend:fig.9b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/11/10 2014/10/16 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 intact-crc:468027097CB23594|rigid:DqLWup3ULbHq5WNZXysLpJkx1T4 false fusion protein:?-? fusion protein:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)