#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P69713	uniprotkb:Q8IUQ4	intact:EBI-7088789|uniprotkb:P03166|uniprotkb:P12935|intact:MINT-8202988	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	psi-mi:x_hbva3(display_long)|uniprotkb:X(gene name)|psi-mi:X(display_short)|uniprotkb:HBx(gene name synonym)|uniprotkb:Peptide X(gene name synonym)|uniprotkb:pX(gene name synonym)	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2011)	pubmed:21878328|imex:IM-16777|mint:MINT-8202979|doi:10.1016/j.febslet.2011.08.015	taxid:480116(hbv-a)|taxid:480116("Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7088810|mint:MINT-8203005|imex:IM-16777-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P69713|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0019079"(viral genome replication)|interpro:IPR000236(Transactivation protein X)|mint:MINT-8203007(identity)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N|mint:MINT-8203008(identity)	-	comment:mint|comment:homomint	-	figure legend:f2a f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/08/09	2014/10/16	rogid:W+dWU0pck7c4dcxXacPa/EdkgAY480116	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	intact-crc:251DF52473EDC9A8|rigid:p+8cQeTdhTl5FvmrmrP9xInWOpg	false	myc tag:?-?(MINT-8203011)	ha tag:?-?(MINT-8203015)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P69713	uniprotkb:Q8IUQ4	intact:EBI-7088789|uniprotkb:P03166|uniprotkb:P12935|intact:MINT-8202988	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	psi-mi:x_hbva3(display_long)|uniprotkb:X(gene name)|psi-mi:X(display_short)|uniprotkb:HBx(gene name synonym)|uniprotkb:Peptide X(gene name synonym)|uniprotkb:pX(gene name synonym)	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2011)	pubmed:21878328|imex:IM-16777|mint:MINT-8202979|doi:10.1016/j.febslet.2011.08.015	taxid:480116(hbv-a)|taxid:480116("Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7088844|mint:MINT-8203019|imex:IM-16777-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P69713|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0019079"(viral genome replication)|interpro:IPR000236(Transactivation protein X)|mint:MINT-8203021(identity)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N|mint:MINT-8203025(identity)	-	comment:mint|comment:homomint	-	figure legend:f2a f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/08/09	2014/10/16	rogid:W+dWU0pck7c4dcxXacPa/EdkgAY480116	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	intact-crc:61223BDB57202BA6|rigid:p+8cQeTdhTl5FvmrmrP9xInWOpg	false	myc tag:?-?(MINT-8203022)	ha tag:?-?(MINT-8203026)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P69713	uniprotkb:Q8IUQ4	intact:EBI-7088789|uniprotkb:P03166|uniprotkb:P12935|intact:MINT-8202988	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	psi-mi:x_hbva3(display_long)|uniprotkb:X(gene name)|psi-mi:X(display_short)|uniprotkb:HBx(gene name synonym)|uniprotkb:Peptide X(gene name synonym)|uniprotkb:pX(gene name synonym)	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhao et al. (2011)	pubmed:21878328|imex:IM-16777|mint:MINT-8202979|doi:10.1016/j.febslet.2011.08.015	taxid:480116(hbv-a)|taxid:480116("Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7088928|mint:MINT-8203035|imex:IM-16777-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P69713|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0019079"(viral genome replication)|interpro:IPR000236(Transactivation protein X)|mint:MINT-8203037(identity)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N|mint:MINT-8203041(identity)	-	comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f2c f2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/09	2014/10/16	rogid:W+dWU0pck7c4dcxXacPa/EdkgAY480116	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	intact-crc:AD4D35B938BA3678|rigid:p+8cQeTdhTl5FvmrmrP9xInWOpg	false	his tag:?-?(MINT-8203038)|binding-associated region:50-136(MINT-8203070)	glutathione s tranferase tag:?-?(MINT-8203042)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P69713	uniprotkb:Q8IUQ4	intact:EBI-7088789|uniprotkb:P03166|uniprotkb:P12935|intact:MINT-8202988	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	psi-mi:x_hbva3(display_long)|uniprotkb:X(gene name)|psi-mi:X(display_short)|uniprotkb:HBx(gene name synonym)|uniprotkb:Peptide X(gene name synonym)|uniprotkb:pX(gene name synonym)	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Zhao et al. (2011)	pubmed:21878328|imex:IM-16777|mint:MINT-8202979|doi:10.1016/j.febslet.2011.08.015	taxid:480116(hbv-a)|taxid:480116("Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7089204|mint:MINT-8203053|imex:IM-16777-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P69713|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0019079"(viral genome replication)|interpro:IPR000236(Transactivation protein X)|mint:MINT-8203055(identity)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N|mint:MINT-8203059(identity)	go:"GO:0048471"(perinuclear region of cytoplasm)	comment:mint|comment:homomint	-	figure legend:f2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_3b)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-null).")	-	2011/08/09	2014/10/16	rogid:W+dWU0pck7c4dcxXacPa/EdkgAY480116	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	intact-crc:D1426305BEF8E087|rigid:p+8cQeTdhTl5FvmrmrP9xInWOpg	false	myc tag:?-?(MINT-8203056)	ha tag:?-?(MINT-8203060)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)