#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P55284 uniprotkb:P35918 intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286 intact:EBI-1555005|uniprotkb:C5H7S5|uniprotkb:Q8VCD0|ensembl:ENSMUSP00000109144 psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym) psi-mi:vgfr2_mouse(display_long)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:Kinase NYK(gene name synonym)|uniprotkb:Kdr(gene name)|psi-mi:Kdr(display_short)|uniprotkb:Flk-1(gene name synonym)|uniprotkb:Flk1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Schulte et al. (2011) doi:10.1038/emboj.2011.304|pubmed:21857650|imex:IM-16682|mint:MINT-8298675 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7087428|mint:MINT-8298686|imex:IM-16682-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2|mint:MINT-8298688(identity) refseq:NP_034742.2|dip:DIP-215N|ensembl:ENSMUSG00000062960(gene)|ensembl:ENSMUST00000113516(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003157"(endocardium development)|go:"GO:0003158"(endothelium development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048469"(cell maturation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1903010"(regulation of bone development)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|reactome:R-MMU-194306|reactome:R-MMU-195399|reactome:R-MMU-216083|reactome:R-MMU-4420097|reactome:R-MMU-5218921|mint:MINT-8298689(identity) - comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions - figure legend:f6a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-endothelioma)|taxid:10090(Mouse endothelioma cells) - 2011/12/14 2021/02/11 rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090 rogid:fjJurWAn1jZTUrOJyl7X9tmNKSU10090 intact-crc:E15C18390016EF27|rigid:wd6HID76TenDjadKbggbsXRF63o false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P55284 uniprotkb:B2RU80 intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286 intact:EBI-7087472|ensembl:ENSMUSP00000089805|uniprotkb:Q3UGZ7|uniprotkb:Q8CIW2|intact:MINT-247274|intact:MINT-8298798 psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym) psi-mi:ptprb_mouse(display_long)|uniprotkb:Ptprb(gene name)|psi-mi:Ptprb(display_short)|uniprotkb:Vascular endothelial protein tyrosine phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Schulte et al. (2011) doi:10.1038/emboj.2011.304|pubmed:21857650|imex:IM-16682|mint:MINT-8298675 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7087467|mint:MINT-8298712|imex:IM-16682-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2|mint:MINT-8298714(identity) ensembl:ENSMUSG00000020154(gene)|ensembl:ENSMUST00000092167(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|reactome:R-MMU-6798695|refseq:NP_084204.2|mint:MINT-8298716(identity) - comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions comment:mint figure legend:f6d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-endothelioma)|taxid:10090(Mouse endothelioma cells) - 2011/12/14 2014/10/16 rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090 rogid:aQEta8FlG3ri6i9330xKJf854qw10090 intact-crc:532C90376323F0E4|rigid:DGn92/8IQy+dc2xfgREVLMgts0M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P33151 uniprotkb:P30999 intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6 intact:EBI-529924|uniprotkb:Q3TSU9|uniprotkb:Q80XQ4|uniprotkb:Q8CHF8|ensembl:ENSMUSP00000064518|ensembl:ENSMUSP00000107320|ensembl:ENSMUSP00000141166 psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym) psi-mi:ctnd1_mouse(display_long)|uniprotkb:Kiaa0384(gene name synonym)|uniprotkb:p120 catenin(gene name synonym)|uniprotkb:Cadherin-associated Src substrate(gene name synonym)|uniprotkb:"p120(cas)"(gene name synonym)|uniprotkb:Ctnnd1(gene name)|psi-mi:Ctnnd1(display_short)|uniprotkb:Catns(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Schulte et al. (2011) doi:10.1038/emboj.2011.304|pubmed:21857650|imex:IM-16682|mint:MINT-8298675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7087526|mint:MINT-8298695|imex:IM-16682-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N|mint:MINT-8298697(identity) refseq:NP_001078917.1|refseq:NP_001078918.1|refseq:NP_001078919.1|refseq:NP_001078922.1|refseq:NP_031641.2|refseq:XP_006498698.1|refseq:XP_017170690.1|refseq:XP_017170697.1|dip:DIP-31972N|ensembl:ENSMUSG00000034101(gene)|ensembl:ENSMUSG00000101645(gene)|ensembl:ENSMUST00000067232(transcript)|ensembl:ENSMUST00000111691(transcript)|ensembl:ENSMUST00000189772(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001822"(kidney development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0043197"(dendritic spine)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060690"(epithelial cell differentiation involved in salivary gland development)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028439|mint:P30999|reactome:R-MMU-418990|reactome:R-MMU-5218920|mint:MINT-8298699(identity) - - - comment:homomint|comment:mint|figure legend:f8d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-lung)|taxid:10090(Mus musculus) - 2011/12/14 2014/10/16 rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606 rogid:CvcAbgejB5iLlsSAxt47G/6W3P410090 intact-crc:FE71295C034A88F1|rigid:PqpnaNesjMxzGdilLwJVPxDN0iE false green fluorescent protein tag:?-?(MINT-8298707) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)