#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05000	uniprotkb:P17181	intact:EBI-4394437|uniprotkb:Q13168|uniprotkb:Q5U802|uniprotkb:Q5VWD0|uniprotkb:Q7M4P5|ensembl:ENSP00000369578	intact:EBI-1547250|uniprotkb:Q53GW9|uniprotkb:Q53H11|uniprotkb:Q8WTZ2|uniprotkb:Q6PKD7|uniprotkb:Q7M4L2|uniprotkb:B4DNT3|uniprotkb:D3DSF0|uniprotkb:B2R6L9|ensembl:ENSP00000270139	psi-mi:ifnw1_human(display_long)|uniprotkb:IFNW1(gene name)|psi-mi:IFNW1(display_short)|uniprotkb:Interferon alpha-II-1(gene name synonym)	psi-mi:inar1_human(display_long)|uniprotkb:IFNAR1(gene name)|psi-mi:IFNAR1(display_short)|uniprotkb:IFNAR(gene name synonym)|uniprotkb:Type I interferon receptor 1(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 1(gene name synonym)|uniprotkb:Cytokine receptor class-II member 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2011)	pubmed:21854986|imex:IM-16594	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4394458|wwpdb:3SE4|imex:IM-16594-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002168.1|ensembl:ENSG00000177047(gene)|ensembl:ENST00000380229(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005132"(type I interferon receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0009615"(response to virus)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042100"(B cell proliferation)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000471(Interferon alpha, beta and delta)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3SE4	refseq:NP_000620.2|refseq:XP_005261021.1|dip:DIP-57N|ensembl:ENSG00000142166(gene)|ensembl:ENST00000270139(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004905"(type I interferon receptor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019962"(type I interferon binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR016669(Interferon-alpha/beta receptor 1)|interpro:IPR036116|rcsb pdb:3S98|rcsb pdb:3SE3|rcsb pdb:3SE4|rcsb pdb:4PO6|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1|3d-resolution:3.5A|3d-r-factors:Rworking = 0.213 Rfree = 0.288|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/31	2014/10/16	rogid:JZrpbpuKG74Z7XD1F+WEz+bT27w9606	rogid:DuOuIr85nya6Ti494f43fftNRyo9606	intact-crc:884E3F147C321787|rigid:ySk2FE4C4CV3HfQjs2rq0CrvrJU	false	sufficient binding region:22-195	sufficient binding region:28-436	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05000	uniprotkb:P48551	intact:EBI-4394437|uniprotkb:Q13168|uniprotkb:Q5U802|uniprotkb:Q5VWD0|uniprotkb:Q7M4P5|ensembl:ENSP00000369578	intact:EBI-958408|uniprotkb:A8KAJ4|uniprotkb:Q6FHD7|uniprotkb:D3DSE8|uniprotkb:D3DSE9|uniprotkb:Q15467|ensembl:ENSP00000343957|ensembl:ENSP00000508013	psi-mi:ifnw1_human(display_long)|uniprotkb:IFNW1(gene name)|psi-mi:IFNW1(display_short)|uniprotkb:Interferon alpha-II-1(gene name synonym)	psi-mi:inar2_human(display_long)|uniprotkb:IFNAR2(gene name)|psi-mi:IFNAR2(display_short)|uniprotkb:IFNARB(gene name synonym)|uniprotkb:Type I interferon receptor 2(gene name synonym)|uniprotkb:IFNABR(gene name synonym)|uniprotkb:Interferon alpha binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2011)	pubmed:21854986|imex:IM-16594	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4394458|wwpdb:3SE4|imex:IM-16594-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002168.1|ensembl:ENSG00000177047(gene)|ensembl:ENST00000380229(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005132"(type I interferon receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0009615"(response to virus)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042100"(B cell proliferation)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000471(Interferon alpha, beta and delta)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3SE4	refseq:NP_000865.2|refseq:NP_997467.1|refseq:NP_997468.1|refseq:NP_001276054.1|refseq:NP_001276055.1|refseq:NP_001276057.1|dip:DIP-945N|ensembl:ENSG00000159110(gene)|ensembl:ENST00000342136(transcript)|ensembl:ENST00000683941(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019962"(type I interferon binding)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0004905"(type I interferon receptor activity)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|mint:P48551|rcsb pdb:1N6U|rcsb pdb:1N6V|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:3S8W|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:3SE4|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1|3d-resolution:3.5A|3d-r-factors:Rworking = 0.213 Rfree = 0.288|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/31	2014/10/16	rogid:JZrpbpuKG74Z7XD1F+WEz+bT27w9606	rogid:n9jPySJ4jlqmT6QgmSlEeNLwUog9606	intact-crc:884E3F147C321787|rigid:ySk2FE4C4CV3HfQjs2rq0CrvrJU	false	sufficient binding region:22-195	sufficient binding region:34-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01563	uniprotkb:P48551	intact:EBI-4394394|uniprotkb:P01564|uniprotkb:Q14606|uniprotkb:Q96KI6|uniprotkb:H2DF54|uniprotkb:H2DF55|uniprotkb:Q6DJX8|ensembl:ENSP00000369554	intact:EBI-958408|uniprotkb:A8KAJ4|uniprotkb:Q6FHD7|uniprotkb:D3DSE8|uniprotkb:D3DSE9|uniprotkb:Q15467|ensembl:ENSP00000343957|ensembl:ENSP00000508013	psi-mi:ifna2_human(display_long)|uniprotkb:IFNA2(gene name)|psi-mi:IFNA2(display_short)|uniprotkb:Interferon alpha-A(gene name synonym)|uniprotkb:IFNA2A(gene name synonym)|uniprotkb:IFNA2B(gene name synonym)|uniprotkb:IFNA2C(gene name synonym)	psi-mi:inar2_human(display_long)|uniprotkb:IFNAR2(gene name)|psi-mi:IFNAR2(display_short)|uniprotkb:IFNARB(gene name synonym)|uniprotkb:Type I interferon receptor 2(gene name synonym)|uniprotkb:IFNABR(gene name synonym)|uniprotkb:Interferon alpha binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2011)	pubmed:21854986|imex:IM-16594	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4394392|wwpdb:3s9d|imex:IM-16594-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000596.2|dip:DIP-481N|ensembl:ENSG00000188379(gene)|ensembl:ENST00000380206(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005132"(type I interferon receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000552"(negative regulation of T-helper 2 cell cytokine production)|interpro:IPR000471(Interferon alpha, beta and delta)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1ITF|rcsb pdb:1RH2|rcsb pdb:2HIE|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:2LMS|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:4YPG|rcsb pdb:4Z5R|reactome:R-HSA-909733|reactome:R-HSA-933541|reactome:R-HSA-983231|reactome:R-HSA-912694	refseq:NP_000865.2|refseq:NP_997467.1|refseq:NP_997468.1|refseq:NP_001276054.1|refseq:NP_001276055.1|refseq:NP_001276057.1|dip:DIP-945N|ensembl:ENSG00000159110(gene)|ensembl:ENST00000342136(transcript)|ensembl:ENST00000683941(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019962"(type I interferon binding)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0004905"(type I interferon receptor activity)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|mint:P48551|rcsb pdb:1N6U|rcsb pdb:1N6V|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:3S8W|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:3SE4|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1|3d-resolution:2.0A|3d-r-factors:Rworking = 0.204 Rfree = 0.233|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/31	2014/10/16	rogid:7tITZF/UiCMChaD4M2HbJ8Iiejo9606	rogid:n9jPySJ4jlqmT6QgmSlEeNLwUog9606	intact-crc:A4ED4024566842FD|rigid:qWaQhdnpx3hHzwiqf+C9SFkWfS0	false	sufficient binding region:24-188	sufficient binding region:37-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01563	uniprotkb:P17181	intact:EBI-4394394|uniprotkb:P01564|uniprotkb:Q14606|uniprotkb:Q96KI6|uniprotkb:H2DF54|uniprotkb:H2DF55|uniprotkb:Q6DJX8|ensembl:ENSP00000369554	intact:EBI-1547250|uniprotkb:Q53GW9|uniprotkb:Q53H11|uniprotkb:Q8WTZ2|uniprotkb:Q6PKD7|uniprotkb:Q7M4L2|uniprotkb:B4DNT3|uniprotkb:D3DSF0|uniprotkb:B2R6L9|ensembl:ENSP00000270139	psi-mi:ifna2_human(display_long)|uniprotkb:IFNA2(gene name)|psi-mi:IFNA2(display_short)|uniprotkb:Interferon alpha-A(gene name synonym)|uniprotkb:IFNA2A(gene name synonym)|uniprotkb:IFNA2B(gene name synonym)|uniprotkb:IFNA2C(gene name synonym)	psi-mi:inar1_human(display_long)|uniprotkb:IFNAR1(gene name)|psi-mi:IFNAR1(display_short)|uniprotkb:IFNAR(gene name synonym)|uniprotkb:Type I interferon receptor 1(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 1(gene name synonym)|uniprotkb:Cytokine receptor class-II member 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2011)	pubmed:21854986|imex:IM-16594	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4394531|wwpdb:3SE3|imex:IM-16594-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000596.2|dip:DIP-481N|ensembl:ENSG00000188379(gene)|ensembl:ENST00000380206(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005132"(type I interferon receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000552"(negative regulation of T-helper 2 cell cytokine production)|interpro:IPR000471(Interferon alpha, beta and delta)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1ITF|rcsb pdb:1RH2|rcsb pdb:2HIE|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:2LMS|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:4YPG|rcsb pdb:4Z5R|reactome:R-HSA-909733|reactome:R-HSA-933541|reactome:R-HSA-983231|reactome:R-HSA-912694	refseq:NP_000620.2|refseq:XP_005261021.1|dip:DIP-57N|ensembl:ENSG00000142166(gene)|ensembl:ENST00000270139(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004905"(type I interferon receptor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019962"(type I interferon binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR016669(Interferon-alpha/beta receptor 1)|interpro:IPR036116|rcsb pdb:3S98|rcsb pdb:3SE3|rcsb pdb:3SE4|rcsb pdb:4PO6|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1|3d-resolution:4.0A|3d-r-factors:Rworking = 0.251 Rfree = 0.311|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/31	2020/07/14	rogid:7tITZF/UiCMChaD4M2HbJ8Iiejo9606	rogid:DuOuIr85nya6Ti494f43fftNRyo9606	intact-crc:6DD2EB4120EEEB0E|rigid:O3OPJyUbwtTENa9y8HyoCZlHbCE	false	-	sufficient binding region:28-436	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01563	uniprotkb:P48551	intact:EBI-4394394|uniprotkb:P01564|uniprotkb:Q14606|uniprotkb:Q96KI6|uniprotkb:H2DF54|uniprotkb:H2DF55|uniprotkb:Q6DJX8|ensembl:ENSP00000369554	intact:EBI-958408|uniprotkb:A8KAJ4|uniprotkb:Q6FHD7|uniprotkb:D3DSE8|uniprotkb:D3DSE9|uniprotkb:Q15467|ensembl:ENSP00000343957|ensembl:ENSP00000508013	psi-mi:ifna2_human(display_long)|uniprotkb:IFNA2(gene name)|psi-mi:IFNA2(display_short)|uniprotkb:Interferon alpha-A(gene name synonym)|uniprotkb:IFNA2A(gene name synonym)|uniprotkb:IFNA2B(gene name synonym)|uniprotkb:IFNA2C(gene name synonym)	psi-mi:inar2_human(display_long)|uniprotkb:IFNAR2(gene name)|psi-mi:IFNAR2(display_short)|uniprotkb:IFNARB(gene name synonym)|uniprotkb:Type I interferon receptor 2(gene name synonym)|uniprotkb:IFNABR(gene name synonym)|uniprotkb:Interferon alpha binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2011)	pubmed:21854986|imex:IM-16594	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4394531|wwpdb:3SE3|imex:IM-16594-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000596.2|dip:DIP-481N|ensembl:ENSG00000188379(gene)|ensembl:ENST00000380206(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005132"(type I interferon receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000552"(negative regulation of T-helper 2 cell cytokine production)|interpro:IPR000471(Interferon alpha, beta and delta)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1ITF|rcsb pdb:1RH2|rcsb pdb:2HIE|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:2LMS|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:4YPG|rcsb pdb:4Z5R|reactome:R-HSA-909733|reactome:R-HSA-933541|reactome:R-HSA-983231|reactome:R-HSA-912694	refseq:NP_000865.2|refseq:NP_997467.1|refseq:NP_997468.1|refseq:NP_001276054.1|refseq:NP_001276055.1|refseq:NP_001276057.1|dip:DIP-945N|ensembl:ENSG00000159110(gene)|ensembl:ENST00000342136(transcript)|ensembl:ENST00000683941(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019962"(type I interferon binding)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0004905"(type I interferon receptor activity)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|mint:P48551|rcsb pdb:1N6U|rcsb pdb:1N6V|rcsb pdb:2HYM|rcsb pdb:2KZ1|rcsb pdb:2LAG|rcsb pdb:3S8W|rcsb pdb:3S9D|rcsb pdb:3SE3|rcsb pdb:3SE4|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9679191	-	-	-	figure legend:Supp. Table 1|3d-resolution:4.0A|3d-r-factors:Rworking = 0.251 Rfree = 0.311|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/31	2020/07/14	rogid:7tITZF/UiCMChaD4M2HbJ8Iiejo9606	rogid:n9jPySJ4jlqmT6QgmSlEeNLwUog9606	intact-crc:6DD2EB4120EEEB0E|rigid:O3OPJyUbwtTENa9y8HyoCZlHbCE	false	-	sufficient binding region:34-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)