#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48168	uniprotkb:P05129	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-949799|ensembl:ENSP00000263431|uniprotkb:B7Z8Q0	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:kpcg_human(display_long)|uniprotkb:PRKCG(gene name)|psi-mi:PRKCG(display_short)|uniprotkb:PKCG(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069192|mint:MINT-8295084|imex:IM-16332-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295087(identity)	go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043278"(response to morphine)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0030425"(dendrite)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0032095"(regulation of response to food)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|mint:P05129|rcsb pdb:2E73|go:"GO:0032425"(positive regulation of mismatch repair)|rcsb pdb:2UZP|reactome:R-HSA-111933|reactome:R-HSA-114516|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-5099900|reactome:R-HSA-76005|ensembl:ENSG00000126583(gene)|ensembl:ENST00000263431(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|refseq:NP_002730.1|refseq:NP_001303258.1|dip:DIP-39795N|mint:MINT-8295086(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:ThSQmsDWSy6dRqz0mFsKIMXH4mk9606	intact-crc:182DA0EA0EE03194|rigid:nf60Vlp2lcpw4rnxwGlPyhr0stw	false	phosphorylated residue:425-425(MINT-8295593)|binding-associated region:400-448(MINT-8295091)|mutation disrupting interaction:425-425(MINT-8295097)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48168	uniprotkb:Q05655	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069266|mint:MINT-8295101|imex:IM-16332-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295103(identity)	refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU|mint:MINT-8295109(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:BR/lNGg6f55rGP91akTf8BLkX449606	intact-crc:416ED47D935A3331|rigid:eVhO8Qfr3paYafT8PIVIM9LrXH4	false	mutation disrupting interaction:425-425(MINT-8295104)|phosphorylated residue:425-425(MINT-8295596)|binding-associated region:400-448(MINT-8295106)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48168	uniprotkb:P05771	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-706216|uniprotkb:O43744|uniprotkb:P05127|uniprotkb:Q15138|uniprotkb:Q93060|uniprotkb:Q9UE49|uniprotkb:Q9UE50|uniprotkb:Q9UEH8|uniprotkb:Q9UJ30|uniprotkb:Q9UJ33|uniprotkb:C5IFJ8|intact:EBI-3396567|uniprotkb:D3DWF5|ensembl:ENSP00000318315	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:kpcb_human(display_long)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069289|mint:MINT-8295113|imex:IM-16332-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295115(identity)	refseq:NP_002729.2|refseq:NP_997700.1|dip:DIP-34187N|ensembl:ENSG00000166501(gene)|ensembl:ENST00000321728(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007165"(signal transduction)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|rcsb pdb:2I0E|reactome:R-HSA-114516|reactome:R-HSA-1169091|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-4419969|reactome:R-HSA-5099900|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-76005|reactome:R-HSA-8939246|mint:MINT-8295121(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:racpanFwAtAbFzE9i3iiHQBPCyg9606	intact-crc:A5C7A28CDAB54132|rigid:tAfwnVTThFap0+HQL1hdkHelhk0	false	binding-associated region:400-448(MINT-8295116)|mutation decreasing interaction:425-425(MINT-8295118)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48168	uniprotkb:Q03555	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-349317	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_rat(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)|uniprotkb:Gph(gene name synonym)|uniprotkb:Putative glycine receptor-tubulin linker protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069317|mint:MINT-8295358|imex:IM-16332-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295360(identity)	rgd:69194|refseq:NP_074056.2|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR038987|interpro:IPR036688|rcsb pdb:1IHC|rcsb pdb:1T3E|rcsb pdb:2FTS|rcsb pdb:2FU3|rcsb pdb:4PD0|rcsb pdb:4PD1|rcsb pdb:4TK1|rcsb pdb:4TK2|rcsb pdb:4TK3|rcsb pdb:4TK4|rcsb pdb:4U90|rcsb pdb:4U91|rcsb pdb:5ERQ|rcsb pdb:5ERR|rcsb pdb:5ERS|rcsb pdb:5ERT|rcsb pdb:5ERU|rcsb pdb:5ERV|rcsb pdb:6FGC|rcsb pdb:6FGD|rcsb pdb:6HSN|rcsb pdb:6HSO|dip:DIP-33263N|reactome:R-RNO-947581|mint:MINT-8295368(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4C F4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.8x10^-7(molar)	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:br2qzn9/bl+2scl7L+bezsDWHFs10116	intact-crc:B49A9F9E440006DB|rigid:jtlvu+ZbRY+GtVHZzc0AmU3c4iE	false	binding-associated region:400-448(MINT-8295365)|mutation decreasing interaction:425-425(MINT-8295363)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48168	uniprotkb:Q03555	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-349317	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_rat(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)|uniprotkb:Gph(gene name synonym)|uniprotkb:Putative glycine receptor-tubulin linker protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069352|mint:MINT-8295380|imex:IM-16332-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295383(identity)	rgd:69194|refseq:NP_074056.2|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR038987|interpro:IPR036688|rcsb pdb:1IHC|rcsb pdb:1T3E|rcsb pdb:2FTS|rcsb pdb:2FU3|rcsb pdb:4PD0|rcsb pdb:4PD1|rcsb pdb:4TK1|rcsb pdb:4TK2|rcsb pdb:4TK3|rcsb pdb:4TK4|rcsb pdb:4U90|rcsb pdb:4U91|rcsb pdb:5ERQ|rcsb pdb:5ERR|rcsb pdb:5ERS|rcsb pdb:5ERT|rcsb pdb:5ERU|rcsb pdb:5ERV|rcsb pdb:6FGC|rcsb pdb:6FGD|rcsb pdb:6HSN|rcsb pdb:6HSO|dip:DIP-33263N|reactome:R-RNO-947581|mint:MINT-8295389(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4C F4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.15x10^-8(molar)	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:br2qzn9/bl+2scl7L+bezsDWHFs10116	intact-crc:0D3E59B0693A4805|rigid:jtlvu+ZbRY+GtVHZzc0AmU3c4iE	false	binding-associated region:400-448(MINT-8295384)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48168	uniprotkb:Q8BUV3	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-771218|uniprotkb:E9QKJ1|ensembl:ENSMUSP00000054064	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_mouse(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)	psi-mi:"MI:0096"(pull down)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069377|mint:MINT-8295133|imex:IM-16332-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295135(identity)	refseq:NP_766540.2|ensembl:ENSMUSG00000047454(gene)|ensembl:ENSMUST00000052472(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688|interpro:IPR038987|mint:Q8BUV3|reactome:R-MMU-947581|mint:MINT-8295141(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:lOuhzjy/8/eDNnV08I0WbLvRiiA10090	intact-crc:0B402C307A0FCA19|rigid:ONohszms7h9iNxT8ntyONgjucIs	false	glutathione s tranferase tag:?-?(MINT-8295150)|binding-associated region:400-448(MINT-8295138)|mutation decreasing interaction:425-425(MINT-8295136)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48168	uniprotkb:Q8BUV3	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-771218|uniprotkb:E9QKJ1|ensembl:ENSMUSP00000054064	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_mouse(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)	psi-mi:"MI:0096"(pull down)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069399|mint:MINT-8295153|imex:IM-16332-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295157(identity)	refseq:NP_766540.2|ensembl:ENSMUSG00000047454(gene)|ensembl:ENSMUST00000052472(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688|interpro:IPR038987|mint:Q8BUV3|reactome:R-MMU-947581|mint:MINT-8295155(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:lOuhzjy/8/eDNnV08I0WbLvRiiA10090	intact-crc:3F2C708D52F5A444|rigid:ONohszms7h9iNxT8ntyONgjucIs	false	glutathione s tranferase tag:?-?(MINT-8295158)|binding-associated region:400-448(MINT-8295162)|mutation decreasing interaction:425-425(MINT-8295160)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48168	uniprotkb:Q8BUV3	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-771218|uniprotkb:E9QKJ1|ensembl:ENSMUSP00000054064	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_mouse(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)	psi-mi:"MI:0096"(pull down)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069458|mint:MINT-8295639|imex:IM-16332-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295643(identity)	refseq:NP_766540.2|ensembl:ENSMUSG00000047454(gene)|ensembl:ENSMUST00000052472(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688|interpro:IPR038987|mint:Q8BUV3|reactome:R-MMU-947581|mint:MINT-8295641(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:lOuhzjy/8/eDNnV08I0WbLvRiiA10090	intact-crc:556EF834756F13E8|rigid:ONohszms7h9iNxT8ntyONgjucIs	false	binding-associated region:400-448(MINT-8295644)|mutation disrupting interaction:422-422(MINT-8295666)|mutation disrupting interaction:420-420(MINT-8295646)|glutathione s tranferase tag:?-?(MINT-8295648)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48168	uniprotkb:Q03555	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-349317	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_rat(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)|uniprotkb:Gph(gene name synonym)|uniprotkb:Putative glycine receptor-tubulin linker protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069421|mint:MINT-8295342|imex:IM-16332-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295346(identity)	rgd:69194|refseq:NP_074056.2|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR038987|interpro:IPR036688|rcsb pdb:1IHC|rcsb pdb:1T3E|rcsb pdb:2FTS|rcsb pdb:2FU3|rcsb pdb:4PD0|rcsb pdb:4PD1|rcsb pdb:4TK1|rcsb pdb:4TK2|rcsb pdb:4TK3|rcsb pdb:4TK4|rcsb pdb:4U90|rcsb pdb:4U91|rcsb pdb:5ERQ|rcsb pdb:5ERR|rcsb pdb:5ERS|rcsb pdb:5ERT|rcsb pdb:5ERU|rcsb pdb:5ERV|rcsb pdb:6FGC|rcsb pdb:6FGD|rcsb pdb:6HSN|rcsb pdb:6HSO|dip:DIP-33263N|reactome:R-RNO-947581|mint:MINT-8295344(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:br2qzn9/bl+2scl7L+bezsDWHFs10116	intact-crc:8E5E88BAF60D866F|rigid:jtlvu+ZbRY+GtVHZzc0AmU3c4iE	false	mutation decreasing interaction:425-425(MINT-8295349)|binding-associated region:400-448(MINT-8295347)|glutathione s tranferase tag:?-?(MINT-8295351)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48168	uniprotkb:Q03555	intact:EBI-7069198|ensembl:ENSMUSP00000029654|uniprotkb:Q5U5X3|intact:MINT-4787310	intact:EBI-349317	psi-mi:glrb_mouse(display_long)|uniprotkb:Glrb(gene name)|psi-mi:Glrb(display_short)|uniprotkb:Glycine receptor 58 kDa subunit(gene name synonym)	psi-mi:geph_rat(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)|uniprotkb:Gph(gene name synonym)|uniprotkb:Putative glycine receptor-tubulin linker protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Specht et al. (2011)	pubmed:21829170|imex:IM-16332|mint:MINT-8295076|doi:10.1038/emboj.2011.276	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7069484|mint:MINT-8295652|imex:IM-16332-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001332884.1|refseq:NP_001332885.1|refseq:NP_001332886.1|refseq:NP_001332887.1|refseq:NP_001332888.1|refseq:NP_001332925.1|ensembl:ENSMUSG00000028020(gene)|go:"GO:0001964"(startle response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016933"(extracellularly glycine-gated ion channel activity)|go:"GO:0016934"(extracellularly glycine-gated chloride channel activity)|go:"GO:0016935"(glycine-gated chloride channel complex)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060012"(synaptic transmission, glycinergic)|go:"GO:0060013"(righting reflex)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008060(Glycine receptor beta)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|mint:P48168|reactome:R-MMU-112314|ensembl:ENSMUST00000029654(transcript)|refseq:NP_034428.2|refseq:NP_001268898.1|mint:MINT-8295654(identity)	rgd:69194|refseq:NP_074056.2|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR038987|interpro:IPR036688|rcsb pdb:1IHC|rcsb pdb:1T3E|rcsb pdb:2FTS|rcsb pdb:2FU3|rcsb pdb:4PD0|rcsb pdb:4PD1|rcsb pdb:4TK1|rcsb pdb:4TK2|rcsb pdb:4TK3|rcsb pdb:4TK4|rcsb pdb:4U90|rcsb pdb:4U91|rcsb pdb:5ERQ|rcsb pdb:5ERR|rcsb pdb:5ERS|rcsb pdb:5ERT|rcsb pdb:5ERU|rcsb pdb:5ERV|rcsb pdb:6FGC|rcsb pdb:6FGD|rcsb pdb:6HSN|rcsb pdb:6HSO|dip:DIP-33263N|reactome:R-RNO-947581|mint:MINT-8295662(identity)	-	comment:mint|function:"The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)"|comment:homomint|function:Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability	-	comment:homomint|comment:mint|figure legend:f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/23	2014/10/16	rogid:7SRzQ6/6TYKQiijd6unKtV6TGtQ10090	rogid:br2qzn9/bl+2scl7L+bezsDWHFs10116	intact-crc:55C44489611D759F|rigid:jtlvu+ZbRY+GtVHZzc0AmU3c4iE	false	mutation disrupting interaction:422-422(MINT-8295670)|mutation disrupting interaction:420-420(MINT-8295657)|binding-associated region:400-448(MINT-8295655)|glutathione s tranferase tag:?-?(MINT-8295659)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)