#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371474|imex:IM-16917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:S2a and S2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:F0BA323C2B4759B0|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	uncategorized protein modification:107-113..113|mutation:315-315|his tag:c-c	10	8	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371474|imex:IM-16917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:S2a and S2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:F0BA323C2B4759B0|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	-	10	12	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371332|imex:IM-16917-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:S2b and S2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:3A9127FEE8EDB845|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	mutation:306-306,330-330,315-315|his tag:c-c|uncategorized protein modification:101-106	10	8	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371332|imex:IM-16917-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:S2b and S2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:3A9127FEE8EDB845|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	-	10	16	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371677|imex:IM-16917-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:6a-d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:A428C29FD76F7C1F|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	mutation:315-315|his tag:c-c|experimental feature:101..106-416	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371677|imex:IM-16917-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:6a-d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:A428C29FD76F7C1F|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371590|imex:IM-16917-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:3E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:E7BA1FD819974586|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	sufficient binding region:101..106-416|his tag:c-c|mutation:315-315|sufficient binding region:n-108,138-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371590|imex:IM-16917-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:3E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:E7BA1FD819974586|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371641|imex:IM-16917-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:5a-e, S5b, S6a and S6b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:014D15CF2736E8DA|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371641|imex:IM-16917-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:5a-e, S5b, S6a and S6b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:014D15CF2736E8DA|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371535|imex:IM-16917-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:1a, 1b and 1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:45666AE4B3AFE35C|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	his tag:c-c|experimental feature:101..106-416|mutation:315-315	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371535|imex:IM-16917-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:1a, 1b and 1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:45666AE4B3AFE35C|rigid:nr1zGiaj713EDxce42lUV3vG3d0	false	his tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371750|imex:IM-16917-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:The Caspase-9 asp315ala mutation in the p20-p10 linker has a significant effect on the final level of pc-9 activation|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:8B9DB01D2B159136|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:?-?|mutation:163-163	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371750|imex:IM-16917-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:The Caspase-9 asp315ala mutation in the p20-p10 linker has a significant effect on the final level of pc-9 activation|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:8B9DB01D2B159136|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:c-c|uncategorized protein modification:101-106|mutation decreasing interaction:315-315	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371750|imex:IM-16917-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:The Caspase-9 asp315ala mutation in the p20-p10 linker has a significant effect on the final level of pc-9 activation|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:8B9DB01D2B159136|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371562|imex:IM-16917-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:3d|comment:Procaspase-9 has a potential linker of approximately 69 residues between the CARD and p20 domain, reducing the size of this linker reduced the catalytic activity of Caspase-9.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:F2FC75FD8BE47E5B|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	mutation:163-163|his tag:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371562|imex:IM-16917-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:3d|comment:Procaspase-9 has a potential linker of approximately 69 residues between the CARD and p20 domain, reducing the size of this linker reduced the catalytic activity of Caspase-9.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:F2FC75FD8BE47E5B|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	his tag:c-c|uncategorized protein modification:101-106|mutation:315-315	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371562|imex:IM-16917-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:3d|comment:Procaspase-9 has a potential linker of approximately 69 residues between the CARD and p20 domain, reducing the size of this linker reduced the catalytic activity of Caspase-9.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:F2FC75FD8BE47E5B|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371611|imex:IM-16917-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:Caspase-9 asp315ala displays significantly reduced cleavage activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:1046013ACEBAE9C9|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:?-?|mutation:163-163	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371611|imex:IM-16917-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:Caspase-9 asp315ala displays significantly reduced cleavage activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:1046013ACEBAE9C9|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:c-c|mutation:315-315|uncategorized protein modification:101-106	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371611|imex:IM-16917-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	figure legend:4a|comment:Caspase-9 asp315ala displays significantly reduced cleavage activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:1046013ACEBAE9C9|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371729|imex:IM-16917-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)	-	-	figure legend:7a and 7b|comment:Unprocessed casp3 does not bind to the casp9-apaf1 complex. Thrombin cleavage of casp9-card region was performed before casp3 addition, showing that unprocessed casp3 does not bind to the apaf1 platform without processing.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:476062B5EE7507DD|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	mutation:163-163|his tag:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371729|imex:IM-16917-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)	-	-	figure legend:7a and 7b|comment:Unprocessed casp3 does not bind to the casp9-apaf1 complex. Thrombin cleavage of casp9-card region was performed before casp3 addition, showing that unprocessed casp3 does not bind to the apaf1 platform without processing.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:476062B5EE7507DD|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	sufficient binding region:1-101..106|mutation:315-315|his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371729|imex:IM-16917-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008303"(caspase complex)	-	-	figure legend:7a and 7b|comment:Unprocessed casp3 does not bind to the casp9-apaf1 complex. Thrombin cleavage of casp9-card region was performed before casp3 addition, showing that unprocessed casp3 does not bind to the apaf1 platform without processing.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:476062B5EE7507DD|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371794|imex:IM-16917-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	figure legend:7c|comment:In this variation of the experiment, casp3 was added before thrombin cleavage and removal of casp9-card region, showing that processed casp3 binds directly to the apaf1 platform.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:9DA28D9D60B9A531|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	mutation:163-163|his tag:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371794|imex:IM-16917-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	figure legend:7c|comment:In this variation of the experiment, casp3 was added before thrombin cleavage and removal of casp9-card region, showing that processed casp3 binds directly to the apaf1 platform.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:9DA28D9D60B9A531|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:c-c|sufficient binding region:1-101..106	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371794|imex:IM-16917-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0008303"(caspase complex)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	figure legend:7c|comment:In this variation of the experiment, casp3 was added before thrombin cleavage and removal of casp9-card region, showing that processed casp3 binds directly to the apaf1 platform.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:9DA28D9D60B9A531|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P42574	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0814"(protease accessibility laddering)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371825|imex:IM-16917-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	-	-	-	figure legend:7d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	intact-crc:0B76B40AD2F4D360|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	mutation:163-163|his tag:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0814"(protease accessibility laddering)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371825|imex:IM-16917-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:7d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:0B76B40AD2F4D360|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	his tag:c-c|uncategorized protein modification:101-106|mutation:315-315	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14727	uniprotkb:P62894	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-4371876|uniprotkb:P00006|uniprotkb:Q2KJD4|ensembl:ENSBTAP00000007918|ensembl:ENSBTAP00000051780	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_bovin(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0814"(protease accessibility laddering)	Yuan et al. (2011)	pubmed:21827945|imex:IM-16917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371825|imex:IM-16917-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001039526.1|refseq:XP_010802623.1|refseq:XP_010808799.1|refseq:XP_005194076.1|ensembl:ENSBTAG00000022613(gene)|ensembl:ENSBTAG00000023823(gene)|ensembl:ENSBTAT00000004594(transcript)|ensembl:ENSBTAT00000007918(transcript)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:2B4Z|rcsb pdb:2YBB|rcsb pdb:5JUY|rcsb pdb:6FF5|reactome:R-BTA-111457|reactome:R-BTA-2151201|reactome:R-BTA-3299685|reactome:R-BTA-5620971|reactome:R-BTA-5628897|reactome:R-BTA-611105|reactome:R-BTA-9707564|rcsb pdb:3J2T|dip:DIP-58978N	-	-	-	figure legend:7d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/18	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:AHfnn+FP0Ekx61vcJWWiNecnHw49913	intact-crc:0B76B40AD2F4D360|rigid:f4aPvAUpvtYe5W+nreZ3/CorlAo	false	his tag:c-c|his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)