#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14164	-	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	-	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5322976|imex:IM-20791-2	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	-	intact-crc:36EFC1071AF05C52	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q8N7N6	uniprotkb:Q14164	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4411055|imex:IM-20791-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	intact-crc:76A03EC727E0C534|rigid:rPz03+RBhpehi44IkoImcBNQwi4	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8N7N6	uniprotkb:Q9R0T8	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-6664658|ensembl:ENSMUSP00000054126|uniprotkb:Q8C2I3	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:ikke_mouse(display_long)|uniprotkb:Ikbke(gene name)|psi-mi:Ikbke(display_short)|uniprotkb:Ikke(gene name synonym)|uniprotkb:Ikki(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664679|imex:IM-20791-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000042349(gene)|ensembl:ENSMUST00000062108(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|reactome:R-MMU-4755510|refseq:XP_011246354.1|refseq:NP_062751.2	-	-	-	figure legend:Fig. 1A|agonist:IL-17|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:M7++x6w5urjZ3RB2LqkzGjz65B410090	intact-crc:980FC77444E0EB91|rigid:fB7S9VM6aclZRzwq/FtyX291Meg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:Q9R0T8	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-6664658|ensembl:ENSMUSP00000054126|uniprotkb:Q8C2I3	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:ikke_mouse(display_long)|uniprotkb:Ikbke(gene name)|psi-mi:Ikbke(display_short)|uniprotkb:Ikke(gene name synonym)|uniprotkb:Ikki(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664684|imex:IM-20791-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000042349(gene)|ensembl:ENSMUST00000062108(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|reactome:R-MMU-4755510|refseq:XP_011246354.1|refseq:NP_062751.2	-	-	-	figure legend:Fig. 1C|agonist:IL-17|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:M7++x6w5urjZ3RB2LqkzGjz65B410090	intact-crc:8A4940FEAFC91536|rigid:fB7S9VM6aclZRzwq/FtyX291Meg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P70191	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-523899|uniprotkb:Q61480|ensembl:ENSMUSP00000141931	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf5_mouse(display_long)|uniprotkb:Traf5(gene name)|psi-mi:Traf5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664689|imex:IM-20791-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000026637(gene)|ensembl:ENSMUST00000195815(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR037308|interpro:IPR043211|rcsb pdb:4GJH|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_035763.2|dip:DIP-34999N	-	-	-	figure legend:Fig. 7B|agonist:IL-17|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:f4UiPm5V8PGnfIFBtZqLQnsYlO810090	intact-crc:8199FA8C2CF91496|rigid:IPOtlQ0Fvbvp6UDkK74pZH1BCFA	false	mutation decreasing interaction:311-311	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P70196	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664689|imex:IM-20791-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	-	-	-	figure legend:Fig. 7B|agonist:IL-17|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:8199FA8C2CF91496|rigid:IPOtlQ0Fvbvp6UDkK74pZH1BCFA	false	mutation decreasing interaction:311-311	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P39429	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664689|imex:IM-20791-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	-	-	-	figure legend:Fig. 7B|agonist:IL-17|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:8199FA8C2CF91496|rigid:IPOtlQ0Fvbvp6UDkK74pZH1BCFA	false	mutation decreasing interaction:311-311	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P70191	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-523899|uniprotkb:Q61480|ensembl:ENSMUSP00000141931	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf5_mouse(display_long)|uniprotkb:Traf5(gene name)|psi-mi:Traf5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664708|imex:IM-20791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000026637(gene)|ensembl:ENSMUST00000195815(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR037308|interpro:IPR043211|rcsb pdb:4GJH|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_035763.2|dip:DIP-34999N	-	-	-	figure legend:Fig. 7A|agonist:IL-17|comment:In Ikki null cells, Act1 can only CoIP TRAF6.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:f4UiPm5V8PGnfIFBtZqLQnsYlO810090	intact-crc:47140E1AE64FCC37|rigid:N+mcIW0vgiMJX38NW+Zbbr6BAmY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P70196	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664708|imex:IM-20791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	-	-	-	figure legend:Fig. 7A|agonist:IL-17|comment:In Ikki null cells, Act1 can only CoIP TRAF6.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:47140E1AE64FCC37|rigid:N+mcIW0vgiMJX38NW+Zbbr6BAmY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:Q9R0T8	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-6664658|ensembl:ENSMUSP00000054126|uniprotkb:Q8C2I3	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:ikke_mouse(display_long)|uniprotkb:Ikbke(gene name)|psi-mi:Ikbke(display_short)|uniprotkb:Ikke(gene name synonym)|uniprotkb:Ikki(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664708|imex:IM-20791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000042349(gene)|ensembl:ENSMUST00000062108(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|reactome:R-MMU-4755510|refseq:XP_011246354.1|refseq:NP_062751.2	-	-	-	figure legend:Fig. 7A|agonist:IL-17|comment:In Ikki null cells, Act1 can only CoIP TRAF6.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:M7++x6w5urjZ3RB2LqkzGjz65B410090	intact-crc:47140E1AE64FCC37|rigid:N+mcIW0vgiMJX38NW+Zbbr6BAmY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7N6	uniprotkb:P39429	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bulek et al. (2011)	pubmed:21822257|imex:IM-20791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6664708|imex:IM-20791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	-	-	-	figure legend:Fig. 7A|agonist:IL-17|comment:In Ikki null cells, Act1 can only CoIP TRAF6.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2011/09/23	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:47140E1AE64FCC37|rigid:N+mcIW0vgiMJX38NW+Zbbr6BAmY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)