#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78395	uniprotkb:P62877	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062335|mint:MINT-8295435|imex:IM-16659-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295437(identity)	refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|mint:MINT-8295440(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:t1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606	intact-crc:7ED88A0978864E70|rigid:9hnub6Tonfb4e9jYC7jXnMnW3M0	false	tag:?-?(MINT-8295454)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062335|mint:MINT-8295435|imex:IM-16659-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295437(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295438(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:t1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:7ED88A0978864E70|rigid:9hnub6Tonfb4e9jYC7jXnMnW3M0	false	tag:?-?(MINT-8295454)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15370	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062335|mint:MINT-8295435|imex:IM-16659-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295437(identity)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N|mint:MINT-8295439(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:t1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:7ED88A0978864E70|rigid:9hnub6Tonfb4e9jYC7jXnMnW3M0	false	tag:?-?(MINT-8295454)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062335|mint:MINT-8295435|imex:IM-16659-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295437(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295441(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:t1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:7ED88A0978864E70|rigid:9hnub6Tonfb4e9jYC7jXnMnW3M0	false	tag:?-?(MINT-8295454)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062360|mint:MINT-8295545|imex:IM-16659-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295548(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295558(identity)	go:"GO:0005634"(nucleus)	-	-	comment:homomint|comment:mint|figure legend:f1c f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:775711A0D9DA2E9D|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	tag:?-?(MINT-8295549)|mutation disrupting interaction:30-30(MINT-8295590)|mutation disrupting interaction:26-26(MINT-8295588)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q15370	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062360|mint:MINT-8295545|imex:IM-16659-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295548(identity)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N|mint:MINT-8295554(identity)	go:"GO:0005634"(nucleus)	-	-	comment:homomint|comment:mint|figure legend:f1c f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:775711A0D9DA2E9D|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	tag:?-?(MINT-8295549)|mutation disrupting interaction:30-30(MINT-8295590)|mutation disrupting interaction:26-26(MINT-8295588)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062360|mint:MINT-8295545|imex:IM-16659-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295548(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295552(identity)	go:"GO:0005634"(nucleus)	-	-	comment:homomint|comment:mint|figure legend:f1c f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:775711A0D9DA2E9D|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	tag:?-?(MINT-8295549)|mutation disrupting interaction:30-30(MINT-8295590)|mutation disrupting interaction:26-26(MINT-8295588)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q15370	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062415|mint:MINT-8295568|imex:IM-16659-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295571(identity)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N|mint:MINT-8295577(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:9F82C385546C1090|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062415|mint:MINT-8295568|imex:IM-16659-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295571(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295575(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:9F82C385546C1090|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062415|mint:MINT-8295568|imex:IM-16659-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295571(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295579(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:9F82C385546C1090|rigid:rArDeMRhCCqO2ADpHqWmGMWFZK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062473|mint:MINT-8295466|imex:IM-16659-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295469(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295479(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:1D95ACEF4D65575D|rigid:0H1x1ZKlUO3IX85D5x0zVL2wdkA	false	ha tag:?-?(MINT-8295470)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15370	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062473|mint:MINT-8295466|imex:IM-16659-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295469(identity)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N|mint:MINT-8295475(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:1D95ACEF4D65575D|rigid:0H1x1ZKlUO3IX85D5x0zVL2wdkA	false	ha tag:?-?(MINT-8295470)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15843	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062473|mint:MINT-8295466|imex:IM-16659-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295469(identity)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-8295477(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	intact-crc:1D95ACEF4D65575D|rigid:0H1x1ZKlUO3IX85D5x0zVL2wdkA	false	ha tag:?-?(MINT-8295470)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062473|mint:MINT-8295466|imex:IM-16659-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295469(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295473(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:1D95ACEF4D65575D|rigid:0H1x1ZKlUO3IX85D5x0zVL2wdkA	false	ha tag:?-?(MINT-8295470)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062512|mint:MINT-8295501|imex:IM-16659-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295503(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295511(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:4587469678E1EA59|rigid:sjyDVN9jGurcS3O5TVtK6uiA5EI	false	ha tag:?-?(MINT-8295504)|mutation disrupting interaction:26-26(MINT-8295517)|mutation disrupting interaction:30-30(MINT-8295520)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062512|mint:MINT-8295501|imex:IM-16659-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295503(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295507(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:4587469678E1EA59|rigid:sjyDVN9jGurcS3O5TVtK6uiA5EI	false	ha tag:?-?(MINT-8295504)|mutation disrupting interaction:26-26(MINT-8295517)|mutation disrupting interaction:30-30(MINT-8295520)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15843	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062512|mint:MINT-8295501|imex:IM-16659-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295503(identity)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-8295513(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	intact-crc:4587469678E1EA59|rigid:sjyDVN9jGurcS3O5TVtK6uiA5EI	false	ha tag:?-?(MINT-8295504)|mutation disrupting interaction:26-26(MINT-8295517)|mutation disrupting interaction:30-30(MINT-8295520)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15843	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062547|mint:MINT-8295524|imex:IM-16659-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295526(identity)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-8295538(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	intact-crc:E1BA1A7A96597594|rigid:b2hQooy1/KoS6+YNNtLvlIumL4g	false	ha tag:?-?(MINT-8295531)|mutation disrupting interaction:48-48(MINT-8295529)|mutation disrupting interaction:49-49(MINT-8295527)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0096"(pull down)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062547|mint:MINT-8295524|imex:IM-16659-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295526(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295536(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:E1BA1A7A96597594|rigid:b2hQooy1/KoS6+YNNtLvlIumL4g	false	ha tag:?-?(MINT-8295531)|mutation disrupting interaction:48-48(MINT-8295529)|mutation disrupting interaction:49-49(MINT-8295527)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78395	uniprotkb:Q15369	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062602|mint:MINT-8295600|imex:IM-16659-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295603(identity)	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8295611(identity)	-	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_21)|taxid:7108(Spodoptera frugiperda insect cells)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:4FBD3308B81FDD89|rigid:/5smUGulncqcOyzpT/KvNraqQcQ	false	flag tag:?-?(MINT-8295608)|mutation decreasing interaction:26-26(MINT-8295606)|mutation decreasing interaction:30-30(MINT-8295604)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78395	uniprotkb:Q13617	intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Costessi et al. (2011)	doi:10.1038/emboj.2011.262|pubmed:21822215|imex:IM-16659|mint:MINT-8295072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7062602|mint:MINT-8295600|imex:IM-16659-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|mint:MINT-8295603(identity)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-8295615(identity)	-	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_21)|taxid:7108(Spodoptera frugiperda insect cells)	-	2011/11/24	2014/10/16	rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:4FBD3308B81FDD89|rigid:/5smUGulncqcOyzpT/KvNraqQcQ	false	flag tag:?-?(MINT-8295608)|mutation decreasing interaction:26-26(MINT-8295606)|mutation decreasing interaction:30-30(MINT-8295604)	his tag:?-?(MINT-8295633)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)