#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WV28 uniprotkb:P45985 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061338|mint:MINT-8287491|imex:IM-16667-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287493(identity) refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)|mint:MINT-8287496(identity) - - - figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ramos b)|taxid:9606(Homo sapiens) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606 intact-crc:C2941660C3E445FD|rigid:iOfaLravWsRMmVymfgzKJb3os8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:Q9Y5K6 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061338|mint:MINT-8287491|imex:IM-16667-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287493(identity) ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N|mint:MINT-8287494(identity) - - - figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ramos b)|taxid:9606(Homo sapiens) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606 intact-crc:C2941660C3E445FD|rigid:iOfaLravWsRMmVymfgzKJb3os8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:Q7L591 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-2834978|uniprotkb:Q8N864|uniprotkb:Q9H666|uniprotkb:Q9BQB3|uniprotkb:E9PAT0|uniprotkb:H7BXS0 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:dok3_human(display_long)|uniprotkb:DOK3(gene name)|psi-mi:DOK3(display_short)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061338|mint:MINT-8287491|imex:IM-16667-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287493(identity) refseq:NP_001295164.1|refseq:NP_001295165.1|go:"GO:0005886"(plasma membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|reactome:R-HSA-6798695|refseq:NP_001138347.1|refseq:NP_001138348.1|refseq:NP_079148.2|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|refseq:XP_005266044.1|interpro:IPR037751|mint:Q7L591|mint:MINT-8287495(identity) - - - figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ramos b)|taxid:9606(Homo sapiens) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:G9EW2VdiFHPeonrp8T8Qbt2qQZQ9606 intact-crc:C2941660C3E445FD|rigid:iOfaLravWsRMmVymfgzKJb3os8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:P62993 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061338|mint:MINT-8287491|imex:IM-16667-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287493(identity) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-8287498(identity) - - - figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ramos b)|taxid:9606(Homo sapiens) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:C2941660C3E445FD|rigid:iOfaLravWsRMmVymfgzKJb3os8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:P16885 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-617403|ensembl:ENSP00000482457|uniprotkb:Q3ZTS2|uniprotkb:Q59H45|uniprotkb:Q969T5|uniprotkb:D3DUL3 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:plcg2_human(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-IV(gene name synonym)|uniprotkb:PLCG2(gene name)|psi-mi:PLCG2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061338|mint:MINT-8287491|imex:IM-16667-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287493(identity) go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P16885|rcsb pdb:2K2J|rcsb pdb:2W2W|rcsb pdb:2W2X|reactome:R-HSA-114604|reactome:R-HSA-166016|reactome:R-HSA-1855204|reactome:R-HSA-202433|reactome:R-HSA-2029485|go:"GO:0097708"(intracellular vesicle)|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9027277|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-2871809|ensembl:ENSG00000197943(gene)|ensembl:ENST00000564138(transcript)|refseq:NP_002652.2|mint:MINT-8287497(identity) - - - figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ramos b)|taxid:9606(Homo sapiens) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:DHqCMVplqyQy7aRvyQyIzXTcphQ9606 intact-crc:C2941660C3E445FD|rigid:iOfaLravWsRMmVymfgzKJb3os8E false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:Q8R550 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7061387|mint:MINT-8287556|imex:IM-16667-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287558(identity) refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1|mint:MINT-8287559(identity) - - - figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-splenic b cell)|taxid:10090(Mus musculus) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090 intact-crc:27A844EE9C7C585E|rigid:s3OCE9sDMZMotc1hwzQ/yRdeptk false green fluorescent protein tag:?-?(MINT-8287561) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5ZMQ7 uniprotkb:Q13094 intact:EBI-7061433|ensembl:ENSGALP00000026438|intact:UNK-5943124|uniprotkb:F1NKX7 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 psi-mi:q5zmq7_chick(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:RCJMB04_1g20(orf name) psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7061427|mint:MINT-8287582|imex:IM-16667-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSGALG00000016420(gene)|ensembl:ENSGALT00000026488(transcript)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|reactome:R-GGA-182971|reactome:R-GGA-6807004|reactome:R-GGA-8856825|reactome:R-GGA-8856828|refseq:NP_001025976.1|mint:MINT-8287588(identity) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-8287584(identity) - comment:mint|comment:homomint - figure legend:f7b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:Fr0emKjWwLPVG+q7rLIGpNCe+AM9031 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 intact-crc:01D2FD68063505EC|rigid:6ZBd3d7nX8Tadrnc1Fi/pSEpQ5M false - mutation increasing interaction:85-85(MINT-8287591)|mutation increasing interaction:334-334(MINT-8287594)|green fluorescent protein tag:?-?(MINT-8287585)|mutation increasing interaction:404-404(MINT-8287600)|mutation increasing interaction:337-337(MINT-8287597) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8WV28 uniprotkb:Q5ZJW0 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-7061481|intact:MINT-8287702 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:q5zjw0_chick(display_long)|uniprotkb:RCJMB04_15f6(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061476|mint:MINT-8287926|imex:IM-16667-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287927(identity)|uniprotkb:Q8WV28(original identifier) refseq:NP_001305332.1|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:MINT-8287941(identity)|uniprotkb:Q5ZJW0(original identifier) - - comment:mint figure legend:F2B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:lciyplKOkGhPq+UIhgOwfWV8u3A9031 intact-crc:21E9E98AD1094C6D|rigid:HJI/UatSAeCQcA+uRlI/gy9OwTc false green fluorescent protein tag:?-?(MINT-8287936)|mutation disrupting interaction:49-49,248-248,313-313(MINT-8287930) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV28 uniprotkb:Q5ZMQ7 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-7061433|ensembl:ENSGALP00000026438|intact:UNK-5943124|uniprotkb:F1NKX7 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:q5zmq7_chick(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:RCJMB04_1g20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061476|mint:MINT-8287926|imex:IM-16667-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287927(identity)|uniprotkb:Q8WV28(original identifier) ensembl:ENSGALG00000016420(gene)|ensembl:ENSGALT00000026488(transcript)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|reactome:R-GGA-182971|reactome:R-GGA-6807004|reactome:R-GGA-8856825|reactome:R-GGA-8856828|refseq:NP_001025976.1|mint:MINT-8287938(identity)|uniprotkb:Q5ZMQ7(original identifier) - - comment:mint|comment:homomint figure legend:F2B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:Fr0emKjWwLPVG+q7rLIGpNCe+AM9031 intact-crc:21E9E98AD1094C6D|rigid:HJI/UatSAeCQcA+uRlI/gy9OwTc false green fluorescent protein tag:?-?(MINT-8287936)|mutation disrupting interaction:49-49,248-248,313-313(MINT-8287930) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5ZMQ7 uniprotkb:Q8WV28 intact:EBI-7061433|ensembl:ENSGALP00000026438|intact:UNK-5943124|uniprotkb:F1NKX7 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 psi-mi:q5zmq7_chick(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:RCJMB04_1g20(orf name) psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7061624|mint:MINT-8288012|imex:IM-16667-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSGALG00000016420(gene)|ensembl:ENSGALT00000026488(transcript)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|reactome:R-GGA-182971|reactome:R-GGA-6807004|reactome:R-GGA-8856825|reactome:R-GGA-8856828|refseq:NP_001025976.1|mint:MINT-8288018(identity)|uniprotkb:Q5ZMQ7(original identifier) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8288013(identity)|uniprotkb:Q8WV28(original identifier) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:F7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:Fr0emKjWwLPVG+q7rLIGpNCe+AM9031 rogid:befGiho6PlVSSMPyb84d31TT/So9606 intact-crc:E82A48DF354876FA|rigid:4nRwPJzZO21nRgIorAHrc5He8wg false - green fluorescent protein tag:?-?(MINT-8288016) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8WV28 uniprotkb:Q9Y5K6 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7061537|mint:MINT-8287967|imex:IM-16667-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287976(identity)|uniprotkb:Q8WV28(original identifier) ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N|mint:MINT-8287968(identity)|uniprotkb:Q9Y5K6(original identifier) - - - figure legend:F2B|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606 intact-crc:0CF62D94CC53C885|rigid:LTY6ffUggQYjL2CRIGzTeeCmYNc false mutation disrupting interaction:49-49,248-248,313-313(MINT-8327980)|his tag:?-?(MINT-8287979) glutathione s tranferase tag:?-?(MINT-8287974)|binding-associated region:1-330(MINT-8287971) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8WV28 uniprotkb:Q5ZJW0 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-7061481|intact:MINT-8287702 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:q5zjw0_chick(display_long)|uniprotkb:RCJMB04_15f6(orf name) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) refseq:NP_001305332.1|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:MINT-8287992(identity)|uniprotkb:Q5ZJW0(original identifier) - - comment:mint figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:lciyplKOkGhPq+UIhgOwfWV8u3A9031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8WV28 uniprotkb:Q07883 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-7061573|intact:MINT-4329661 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:grb2_chick(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) mint:Q07883|interpro:IPR035641|interpro:IPR035643|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|refseq:NP_989742.1|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR036028|interpro:IPR036860|mint:MINT-8287995(identity)|uniprotkb:Q07883(original identifier) - - function:Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway|comment:mint figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:4t5yMJlEblUBYSf4BQ/m9HLlz/I9031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8WV28 uniprotkb:Q5ZMQ7 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-7061433|ensembl:ENSGALP00000026438|intact:UNK-5943124|uniprotkb:F1NKX7 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:q5zmq7_chick(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:RCJMB04_1g20(orf name) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) ensembl:ENSGALG00000016420(gene)|ensembl:ENSGALT00000026488(transcript)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|reactome:R-GGA-182971|reactome:R-GGA-6807004|reactome:R-GGA-8856825|reactome:R-GGA-8856828|refseq:NP_001025976.1|mint:MINT-8287989(identity)|uniprotkb:Q5ZMQ7(original identifier) - - comment:mint|comment:homomint figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:Fr0emKjWwLPVG+q7rLIGpNCe+AM9031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8WV28 uniprotkb:P14315 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-1036030|ensembl:ENSGALP00000006415|ensembl:ENSGALP00000049427 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:capzb_chick(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ B1 and B2(gene name synonym)|uniprotkb:CapZ 36/32(gene name synonym)|uniprotkb:Beta-actinin subunit II(gene name synonym) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) refseq:XP_015152321.1|refseq:NP_001167000.1|refseq:NP_990768.1|ensembl:ENSGALG00000004034(gene)|ensembl:ENSGALT00000006425(transcript)|ensembl:ENSGALT00000061238(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P14315|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|rcsb pdb:1IZN|rcsb pdb:2KXP|rcsb pdb:2KZ7|rcsb pdb:3AA0|rcsb pdb:3AA1|rcsb pdb:3AA6|rcsb pdb:3AA7|rcsb pdb:3AAA|rcsb pdb:3AAE|rcsb pdb:3LK2|rcsb pdb:3LK3|rcsb pdb:3LK4|rcsb pdb:7DS2|rcsb pdb:7DS3|rcsb pdb:7DS4|rcsb pdb:7DS6|rcsb pdb:7DS8|rcsb pdb:7DSA|rcsb pdb:7DSB|reactome:R-GGA-3371497|reactome:R-GGA-6807878|reactome:R-GGA-6811436|reactome:R-GGA-9013405|reactome:R-GGA-9035034|reactome:R-GGA-983231|dip:DIP-35365N|mint:MINT-8288001(identity)|uniprotkb:P14315(original identifier) - - - figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:J3X7K29iDLq7l17NnuSF/6r+YYg9031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8WV28 uniprotkb:P13127 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-1036025|ensembl:ENSGALP00000056898 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:caza1_chick(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ 36/32(gene name synonym)|uniprotkb:Beta-actinin subunit I(gene name synonym) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) refseq:NP_990846.1|ensembl:ENSGALG00000001547(gene)|ensembl:ENSGALT00000056559(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P13127|rcsb pdb:1IZN|rcsb pdb:2KXP|rcsb pdb:2KZ7|rcsb pdb:3AA0|rcsb pdb:3AA1|rcsb pdb:3AA6|rcsb pdb:3AA7|rcsb pdb:3AAA|rcsb pdb:3AAE|rcsb pdb:3LK2|rcsb pdb:3LK3|rcsb pdb:3LK4|rcsb pdb:7DS2|rcsb pdb:7DS3|rcsb pdb:7DS4|rcsb pdb:7DS6|rcsb pdb:7DS8|rcsb pdb:7DSA|rcsb pdb:7DSB|reactome:R-GGA-3371497|reactome:R-GGA-6807878|reactome:R-GGA-6811436|reactome:R-GGA-879415|reactome:R-GGA-983231|dip:DIP-35364N|mint:MINT-8287998(identity)|uniprotkb:P13127(original identifier) - - - figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:7iXkRm4VLsdgzy5Yy3YVCPXvXN09031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8WV28 uniprotkb:P28497 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 intact:EBI-1636232|ensembl:ENSGALP00000056878 psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:caza2_chick(display_long)|uniprotkb:CAPZA2(gene name)|psi-mi:CAPZA2(display_short)|uniprotkb:CapZ 36/32(gene name synonym)|uniprotkb:Beta-actinin subunit I(gene name synonym) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7061568|mint:MINT-8287981|imex:IM-16667-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8287982(identity)|uniprotkb:Q8WV28(original identifier) refseq:NP_001004380.1|ensembl:ENSGALG00000043437(gene)|ensembl:ENSGALT00000053621(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|reactome:R-GGA-3371497|reactome:R-GGA-6807878|reactome:R-GGA-6811436|reactome:R-GGA-879415|reactome:R-GGA-983231|mint:MINT-8288004(identity)|uniprotkb:P28497(original identifier) - - - figure legend:F2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma) - 2011/11/04 2014/10/16 rogid:befGiho6PlVSSMPyb84d31TT/So9606 rogid:wLAEKnds+4lF1AsJLvG+2VhhYCs9031 intact-crc:3A9A6DDBD7A9ED9B|rigid:uS+fFpAVUW9HfiKJPW0kQdfSN+w false binding-associated region:235-253(MINT-8287985)|biotin tag:?-?(MINT-8287987) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96B97 uniprotkb:Q8WV28 intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym) psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:"MI:0096"(pull down) Oellerich et al. (2011) doi:10.1038/emboj.2011.251|pubmed:21822214|imex:IM-16667|mint:MINT-8287480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7061650|mint:MINT-8328032|imex:IM-16667-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)|mint:MINT-8328034(identity) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-8328036(identity) - - - figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/04 2014/10/16 rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606 rogid:befGiho6PlVSSMPyb84d31TT/So9606 intact-crc:37CA9A19D49D74F0|rigid:pRlumKsEjVkZxLfbagn3BW6jubo false glutathione s tranferase tag:?-?(MINT-8328040)|binding-associated region:1-328(MINT-8328043) his tag:?-?(MINT-8328047) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot)