#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15941-7 uniprotkb:P15941 intact:EBI-4396776|ensembl:ENSP00000357375 intact:EBI-2804728|uniprotkb:Q6S4Y3|uniprotkb:Q7Z547|uniprotkb:Q7Z552|uniprotkb:P17626|uniprotkb:Q9UE76|uniprotkb:Q16442|uniprotkb:Q16615|uniprotkb:Q9Y4J2|uniprotkb:Q9UE75|uniprotkb:P13931|uniprotkb:Q9UQL1|uniprotkb:Q9BXA4|uniprotkb:P15942|uniprotkb:Q16437|uniprotkb:Q14128|uniprotkb:Q14876|uniprotkb:B1AVQ8|uniprotkb:B1AVR0|uniprotkb:Q0VAP6|uniprotkb:A6ZID9|uniprotkb:E7EUG9|uniprotkb:Q0VAP5|uniprotkb:Q7Z550|uniprotkb:A5YRV1|uniprotkb:B6ECA1|uniprotkb:E7ESE5|uniprotkb:Q7Z548|uniprotkb:A6ZIE0 psi-mi:p15941-7(display_long)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:MUC1/Y(isoform synonym)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:muc1_human(display_long)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bernier et al. (2011) pubmed:21798038|imex:IM-16872 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-4371099|imex:IM-16872-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2804728(isoform-parent)|ensembl:ENSG00000185499(gene)|ensembl:ENST00000368390(transcript)|uniprotkb:P15941-7(isoform-parent) go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000082(SEA)|interpro:IPR036364|rcsb pdb:1SM3|rcsb pdb:2ACM|rcsb pdb:2FO4|rcsb pdb:5T6P|rcsb pdb:5T78|rcsb pdb:6FZQ|rcsb pdb:6FZR|rcsb pdb:6KX1|rcsb pdb:6TGG|reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-5621480|reactome:R-HSA-6785807|reactome:R-HSA-913709|reactome:R-HSA-977068|refseq:NP_001018016.1|refseq:NP_001018017.1|refseq:NP_001037855.1|refseq:NP_001037856.1|refseq:NP_001037857.1|refseq:NP_001037858.1|refseq:NP_001191214.1|refseq:NP_001191215.1|refseq:NP_001191216.1|refseq:NP_001191217.1|refseq:NP_001191218.1|refseq:NP_001191219.1|refseq:NP_001191220.1|refseq:NP_001191221.1|refseq:NP_001191222.1|refseq:NP_001191223.1|refseq:NP_001191224.1|refseq:NP_001191225.1|refseq:NP_001191226.1|refseq:NP_002447.4|dip:DIP-41890N|mint:P15941 - - - figure legend:Fig3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/08/18 2014/10/16 rogid:ODhiACwtOd8T7yGo0P74rAOn6KA9606 rogid:RtvHfzXLy3sZaikeLfDNQeZ/0oY9606 intact-crc:4EBB3A0E3DAE5727|rigid:caDGVzlYTqHItFiDcsAKql3skjg false yellow fluorescent protein tag:c-c necessary binding region:1187-1255|fusion protein:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P12931 uniprotkb:P15941 intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4 intact:EBI-2804728|uniprotkb:Q6S4Y3|uniprotkb:Q7Z547|uniprotkb:Q7Z552|uniprotkb:P17626|uniprotkb:Q9UE76|uniprotkb:Q16442|uniprotkb:Q16615|uniprotkb:Q9Y4J2|uniprotkb:Q9UE75|uniprotkb:P13931|uniprotkb:Q9UQL1|uniprotkb:Q9BXA4|uniprotkb:P15942|uniprotkb:Q16437|uniprotkb:Q14128|uniprotkb:Q14876|uniprotkb:B1AVQ8|uniprotkb:B1AVR0|uniprotkb:Q0VAP6|uniprotkb:A6ZID9|uniprotkb:E7EUG9|uniprotkb:Q0VAP5|uniprotkb:Q7Z550|uniprotkb:A5YRV1|uniprotkb:B6ECA1|uniprotkb:E7ESE5|uniprotkb:Q7Z548|uniprotkb:A6ZIE0 psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:muc1_human(display_long)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bernier et al. (2011) pubmed:21798038|imex:IM-16872 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-4371109|imex:IM-16872-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000082(SEA)|interpro:IPR036364|rcsb pdb:1SM3|rcsb pdb:2ACM|rcsb pdb:2FO4|rcsb pdb:5T6P|rcsb pdb:5T78|rcsb pdb:6FZQ|rcsb pdb:6FZR|rcsb pdb:6KX1|rcsb pdb:6TGG|reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-5621480|reactome:R-HSA-6785807|reactome:R-HSA-913709|reactome:R-HSA-977068|refseq:NP_001018016.1|refseq:NP_001018017.1|refseq:NP_001037855.1|refseq:NP_001037856.1|refseq:NP_001037857.1|refseq:NP_001037858.1|refseq:NP_001191214.1|refseq:NP_001191215.1|refseq:NP_001191216.1|refseq:NP_001191217.1|refseq:NP_001191218.1|refseq:NP_001191219.1|refseq:NP_001191220.1|refseq:NP_001191221.1|refseq:NP_001191222.1|refseq:NP_001191223.1|refseq:NP_001191224.1|refseq:NP_001191225.1|refseq:NP_001191226.1|refseq:NP_002447.4|dip:DIP-41890N|mint:P15941 - - - figure legend:Fig6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/08/18 2014/10/16 rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606 rogid:RtvHfzXLy3sZaikeLfDNQeZ/0oY9606 intact-crc:C12414CA64D6645A|rigid:7aRZGYhUJ5kVR6d2F/q5klBkfeI false - cyan fluorescent protein tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P15941 uniprotkb:P15941-7 intact:EBI-2804728|uniprotkb:Q6S4Y3|uniprotkb:Q7Z547|uniprotkb:Q7Z552|uniprotkb:P17626|uniprotkb:Q9UE76|uniprotkb:Q16442|uniprotkb:Q16615|uniprotkb:Q9Y4J2|uniprotkb:Q9UE75|uniprotkb:P13931|uniprotkb:Q9UQL1|uniprotkb:Q9BXA4|uniprotkb:P15942|uniprotkb:Q16437|uniprotkb:Q14128|uniprotkb:Q14876|uniprotkb:B1AVQ8|uniprotkb:B1AVR0|uniprotkb:Q0VAP6|uniprotkb:A6ZID9|uniprotkb:E7EUG9|uniprotkb:Q0VAP5|uniprotkb:Q7Z550|uniprotkb:A5YRV1|uniprotkb:B6ECA1|uniprotkb:E7ESE5|uniprotkb:Q7Z548|uniprotkb:A6ZIE0 intact:EBI-4396776|ensembl:ENSP00000357375 psi-mi:muc1_human(display_long)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:p15941-7(display_long)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:MUC1/Y(isoform synonym)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Bernier et al. (2011) pubmed:21798038|imex:IM-16872 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-4396807|imex:IM-16872-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000082(SEA)|interpro:IPR036364|rcsb pdb:1SM3|rcsb pdb:2ACM|rcsb pdb:2FO4|rcsb pdb:5T6P|rcsb pdb:5T78|rcsb pdb:6FZQ|rcsb pdb:6FZR|rcsb pdb:6KX1|rcsb pdb:6TGG|reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-5621480|reactome:R-HSA-6785807|reactome:R-HSA-913709|reactome:R-HSA-977068|refseq:NP_001018016.1|refseq:NP_001018017.1|refseq:NP_001037855.1|refseq:NP_001037856.1|refseq:NP_001037857.1|refseq:NP_001037858.1|refseq:NP_001191214.1|refseq:NP_001191215.1|refseq:NP_001191216.1|refseq:NP_001191217.1|refseq:NP_001191218.1|refseq:NP_001191219.1|refseq:NP_001191220.1|refseq:NP_001191221.1|refseq:NP_001191222.1|refseq:NP_001191223.1|refseq:NP_001191224.1|refseq:NP_001191225.1|refseq:NP_001191226.1|refseq:NP_002447.4|dip:DIP-41890N|mint:P15941 intact:EBI-2804728(isoform-parent)|ensembl:ENSG00000185499(gene)|ensembl:ENST00000368390(transcript)|uniprotkb:P15941-7(isoform-parent) - - - figure legend:Fig3b|agonist:Disuccinimidyl suberate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/08/18 2014/10/16 rogid:RtvHfzXLy3sZaikeLfDNQeZ/0oY9606 rogid:ODhiACwtOd8T7yGo0P74rAOn6KA9606 intact-crc:91B2E113B34389E8|rigid:caDGVzlYTqHItFiDcsAKql3skjg false cyan fluorescent protein tag:c-c yellow fluorescent protein tag:c-c 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15941 uniprotkb:P15941 intact:EBI-2804728|uniprotkb:Q6S4Y3|uniprotkb:Q7Z547|uniprotkb:Q7Z552|uniprotkb:P17626|uniprotkb:Q9UE76|uniprotkb:Q16442|uniprotkb:Q16615|uniprotkb:Q9Y4J2|uniprotkb:Q9UE75|uniprotkb:P13931|uniprotkb:Q9UQL1|uniprotkb:Q9BXA4|uniprotkb:P15942|uniprotkb:Q16437|uniprotkb:Q14128|uniprotkb:Q14876|uniprotkb:B1AVQ8|uniprotkb:B1AVR0|uniprotkb:Q0VAP6|uniprotkb:A6ZID9|uniprotkb:E7EUG9|uniprotkb:Q0VAP5|uniprotkb:Q7Z550|uniprotkb:A5YRV1|uniprotkb:B6ECA1|uniprotkb:E7ESE5|uniprotkb:Q7Z548|uniprotkb:A6ZIE0 intact:EBI-2804728|uniprotkb:Q6S4Y3|uniprotkb:Q7Z547|uniprotkb:Q7Z552|uniprotkb:P17626|uniprotkb:Q9UE76|uniprotkb:Q16442|uniprotkb:Q16615|uniprotkb:Q9Y4J2|uniprotkb:Q9UE75|uniprotkb:P13931|uniprotkb:Q9UQL1|uniprotkb:Q9BXA4|uniprotkb:P15942|uniprotkb:Q16437|uniprotkb:Q14128|uniprotkb:Q14876|uniprotkb:B1AVQ8|uniprotkb:B1AVR0|uniprotkb:Q0VAP6|uniprotkb:A6ZID9|uniprotkb:E7EUG9|uniprotkb:Q0VAP5|uniprotkb:Q7Z550|uniprotkb:A5YRV1|uniprotkb:B6ECA1|uniprotkb:E7ESE5|uniprotkb:Q7Z548|uniprotkb:A6ZIE0 psi-mi:muc1_human(display_long)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:muc1_human(display_long)|uniprotkb:Krebs von den Lungen-6(gene name synonym)|uniprotkb:PUM(gene name synonym)|uniprotkb:Breast carcinoma-associated antigen DF3(gene name synonym)|uniprotkb:Carcinoma-associated mucin(gene name synonym)|uniprotkb:Episialin(gene name synonym)|uniprotkb:H23AG(gene name synonym)|uniprotkb:PEMT(gene name synonym)|uniprotkb:Peanut-reactive urinary mucin(gene name synonym)|uniprotkb:Polymorphic epithelial mucin(gene name synonym)|uniprotkb:Tumor-associated epithelial membrane antigen(gene name synonym)|uniprotkb:Tumor-associated mucin(gene name synonym)|uniprotkb:MUC1(gene name)|psi-mi:MUC1(display_short)|uniprotkb:Cancer antigen 15-3(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Bernier et al. (2011) pubmed:21798038|imex:IM-16872 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1263"(Molecular Connections) intact:EBI-4396816|imex:IM-16872-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000082(SEA)|interpro:IPR036364|rcsb pdb:1SM3|rcsb pdb:2ACM|rcsb pdb:2FO4|rcsb pdb:5T6P|rcsb pdb:5T78|rcsb pdb:6FZQ|rcsb pdb:6FZR|rcsb pdb:6KX1|rcsb pdb:6TGG|reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-5621480|reactome:R-HSA-6785807|reactome:R-HSA-913709|reactome:R-HSA-977068|refseq:NP_001018016.1|refseq:NP_001018017.1|refseq:NP_001037855.1|refseq:NP_001037856.1|refseq:NP_001037857.1|refseq:NP_001037858.1|refseq:NP_001191214.1|refseq:NP_001191215.1|refseq:NP_001191216.1|refseq:NP_001191217.1|refseq:NP_001191218.1|refseq:NP_001191219.1|refseq:NP_001191220.1|refseq:NP_001191221.1|refseq:NP_001191222.1|refseq:NP_001191223.1|refseq:NP_001191224.1|refseq:NP_001191225.1|refseq:NP_001191226.1|refseq:NP_002447.4|dip:DIP-41890N|mint:P15941 go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000082(SEA)|interpro:IPR036364|rcsb pdb:1SM3|rcsb pdb:2ACM|rcsb pdb:2FO4|rcsb pdb:5T6P|rcsb pdb:5T78|rcsb pdb:6FZQ|rcsb pdb:6FZR|rcsb pdb:6KX1|rcsb pdb:6TGG|reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-5621480|reactome:R-HSA-6785807|reactome:R-HSA-913709|reactome:R-HSA-977068|refseq:NP_001018016.1|refseq:NP_001018017.1|refseq:NP_001037855.1|refseq:NP_001037856.1|refseq:NP_001037857.1|refseq:NP_001037858.1|refseq:NP_001191214.1|refseq:NP_001191215.1|refseq:NP_001191216.1|refseq:NP_001191217.1|refseq:NP_001191218.1|refseq:NP_001191219.1|refseq:NP_001191220.1|refseq:NP_001191221.1|refseq:NP_001191222.1|refseq:NP_001191223.1|refseq:NP_001191224.1|refseq:NP_001191225.1|refseq:NP_001191226.1|refseq:NP_002447.4|dip:DIP-41890N|mint:P15941 - - - figure legend:Fig4b|comment:MUC1-CD dimerization is independent of membrane-proximal cysteine residues|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/08/18 2014/10/16 rogid:RtvHfzXLy3sZaikeLfDNQeZ/0oY9606 rogid:RtvHfzXLy3sZaikeLfDNQeZ/0oY9606 intact-crc:5B3E2A5E7BF1BB14|rigid:tiD/K07GeOWSDvfAoIghEu9EPv8 false necessary binding region:1187-1255|cyan fluorescent protein tag:c-c necessary binding region:1187-1255|cyan fluorescent protein tag:c-c - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)