#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15111	-	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	-	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4398820|imex:IM-16577-1	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/11	2014/10/16	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	-	intact-crc:9F030D819F807A33	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:O15111	uniprotkb:Q86VP1	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405452|imex:IM-16577-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/11	2014/10/16	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	intact-crc:AA373206BD48EE58|rigid:qsNkK4bbNDS+dmNQ+Zt/cwIjXvU	false	glutathione s tranferase tag:?-?	sufficient binding region:205-599|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O14920	-	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	-	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405461|imex:IM-16577-3	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/11	2014/10/16	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	-	intact-crc:25D606439186053B	false	his tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:P25963	uniprotkb:O15111	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405470|imex:IM-16577-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/11	2014/10/16	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	intact-crc:D80566D831837FAB|rigid:kFRxKPlJipoagDxrSzCTP3vbGvw	false	sufficient binding region:1-54|glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P25963	uniprotkb:O14920	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405481|imex:IM-16577-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/11	2014/10/16	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:DE00626F96A9C46B|rigid:Npc10m833ra1+/T8jvEvVHUVPU4	false	sufficient binding region:1-54|glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O15111	uniprotkb:Q86VP1	intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405502|imex:IM-16577-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	psi-mi:"MI:0469"(intact)	-	-	comment:Tax1bp1 null MEF complemented with human TAX1BP1|agonist:TNF or IL1|figure legend:Fig. 1G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:FVB/gXjSBTB9hdq9pycQogxesms9606	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	intact-crc:D4EF550F9A107193|rigid:qsNkK4bbNDS+dmNQ+Zt/cwIjXvU	false	ha tag:?-?|mutation disrupting interaction:44-44	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60680	uniprotkb:Q86VP1-2	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	intact:EBI-5261409|ensembl:ENSP00000265393|ensembl:ENSP00000444811	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:q86vp1-2(display_long)|uniprotkb:TXBP151-L(isoform synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405511|imex:IM-16577-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	intact:EBI-529518(isoform-parent)|uniprotkb:Q86VP1-2(isoform-parent)|ensembl:ENSG00000106052(gene)|ensembl:ENST00000265393(transcript)|ensembl:ENST00000543117(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|agonist:TNF|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:iB5yOObdvhrQlcIqhxAL0O49/T09606	intact-crc:4F8A8D335A897592|rigid:dX2TRnU2saHPamdgJ84Tz5C6LwE	false	-	flag tag:?-?|mutation disrupting interaction:624-624	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P39429	uniprotkb:Q60769	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q62210	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-647504|uniprotkb:O08864|uniprotkb:A6H6S7|ensembl:ENSMUSP00000091422|ensembl:ENSMUSP00000140049	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:birc2_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:Birc2(gene name)|psi-mi:Birc2(display_short)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_031491.2|refseq:NP_001278432.1|refseq:XP_017168599.1|ensembl:ENSMUSG00000057367(gene)|ensembl:ENSMUST00000074246(transcript)|ensembl:ENSMUST00000190341(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q62210|reactome:R-MMU-111465|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|go:"GO:0071356"(cellular response to tumor necrosis factor)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:dYfLagyPs9Ceg7miQnJCJzKHRPk10090	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q60855	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q86VP1-2	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-5261409|ensembl:ENSP00000265393|ensembl:ENSP00000444811	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:q86vp1-2(display_long)|uniprotkb:TXBP151-L(isoform synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	intact:EBI-529518(isoform-parent)|uniprotkb:Q86VP1-2(isoform-parent)|ensembl:ENSG00000106052(gene)|ensembl:ENST00000265393(transcript)|ensembl:ENST00000543117(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:iB5yOObdvhrQlcIqhxAL0O49/T09606	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	flag tag:?-?|mutation disrupting interaction:593-593,624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:P61089	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-494560|uniprotkb:Q16781|uniprotkb:Q3TSL6|uniprotkb:Q6ZWZ0|uniprotkb:Q9DAJ6|ensembl:ENSMUSP00000096932	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:ube2n_mouse(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)|uniprotkb:Ube2n(gene name)|psi-mi:Ube2n(display_short)|uniprotkb:Blu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_542127.1|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61089|reactome:R-MMU-1169408|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-8866654|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-9646399|reactome:R-MMU-975144|reactome:R-MMU-983168|ensembl:ENSMUSG00000074781(gene)|ensembl:ENSMUST00000099329(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz810090	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q8C863	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405540|imex:IM-16577-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|agonist:TNF|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13, RIP1 and cIAP1 with TRAF-2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	intact-crc:66FD5C27AD195D38|rigid:EJout8EuiTo2ejZaD9aFtTU8kGA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q86VP1-2	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-5261409|ensembl:ENSP00000265393|ensembl:ENSP00000444811	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:q86vp1-2(display_long)|uniprotkb:TXBP151-L(isoform synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	intact:EBI-529518(isoform-parent)|uniprotkb:Q86VP1-2(isoform-parent)|ensembl:ENSG00000106052(gene)|ensembl:ENST00000265393(transcript)|ensembl:ENST00000543117(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:iB5yOObdvhrQlcIqhxAL0O49/T09606	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	mutation disrupting interaction:593-593,624-624|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q8C863	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q9QYK7	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:P61089	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-494560|uniprotkb:Q16781|uniprotkb:Q3TSL6|uniprotkb:Q6ZWZ0|uniprotkb:Q9DAJ6|ensembl:ENSMUSP00000096932	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:ube2n_mouse(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)|uniprotkb:Ube2n(gene name)|psi-mi:Ube2n(display_short)|uniprotkb:Blu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_542127.1|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61089|reactome:R-MMU-1169408|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-8866654|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-9646399|reactome:R-MMU-975144|reactome:R-MMU-983168|ensembl:ENSMUSG00000074781(gene)|ensembl:ENSMUST00000099329(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz810090	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q8CFI2	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-1202331|uniprotkb:Q505K8|ensembl:ENSMUSP00000020550|ensembl:ENSMUSP00000128806	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:ub2r1_mouse(display_long)|uniprotkb:Cdc34(gene name)|psi-mi:Cdc34(display_short)|uniprotkb:Ubch3(gene name synonym)|uniprotkb:Ube2r1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase R1(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-32 kDa complementing(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme R1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_808281.1|refseq:XP_017169376.1|refseq:XP_017169377.1|ensembl:ENSMUSG00000020307(gene)|ensembl:ENSMUST00000020550(transcript)|ensembl:ENSMUST00000166603(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090261"(positive regulation of inclusion body assembly)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866652|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:KIefaK+KdntC6GNRmudUc2AozYQ10090	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q60769	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405824|imex:IM-16577-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|agonist:IL-1|comment:"Tax1bp1-deficient MEFs and  MEFs transfected with   TAX1BP1(S593A,S624A) failed to interact with TRAF2 or TRAF6 and  were also impaired in the recruitment of Itch, RNF11 and A20 to the TRAF proteins.  Transfection of wild-type (phosphorylated) TAX1BP1  reduced the interactions between  Ubc13 and Cdc34 with TRAF-6."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	intact-crc:891BFFECCC6900CD|rigid:GJQx6jqcVu2p4hCSM2Heinc+MYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q60769	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405875|imex:IM-16577-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5C|agonist:"TNF (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	intact-crc:E51D4B38868C3FD3|rigid:z7p2GI8K2V3Lfb2AiWXQIJCnj2g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q86VP1-2	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-5261409|ensembl:ENSP00000265393|ensembl:ENSP00000444811	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:q86vp1-2(display_long)|uniprotkb:TXBP151-L(isoform synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405875|imex:IM-16577-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	intact:EBI-529518(isoform-parent)|uniprotkb:Q86VP1-2(isoform-parent)|ensembl:ENSG00000106052(gene)|ensembl:ENST00000265393(transcript)|ensembl:ENST00000543117(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5C|agonist:"TNF (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:iB5yOObdvhrQlcIqhxAL0O49/T09606	intact-crc:E51D4B38868C3FD3|rigid:z7p2GI8K2V3Lfb2AiWXQIJCnj2g	false	-	mutation disrupting interaction:593-593|mutation disrupting interaction:624-624,593-593|flag tag:?-?|mutation disrupting interaction:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q8C863	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405875|imex:IM-16577-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5C|agonist:"TNF (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	intact-crc:E51D4B38868C3FD3|rigid:z7p2GI8K2V3Lfb2AiWXQIJCnj2g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q60855	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405875|imex:IM-16577-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5C|agonist:"TNF (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	intact-crc:E51D4B38868C3FD3|rigid:z7p2GI8K2V3Lfb2AiWXQIJCnj2g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q60769	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405910|imex:IM-16577-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|agonist:"IL-1 (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	intact-crc:9E4912C7825D8197|rigid:nE5dzR3qHy9QUgQiaY0O17Hd2Iw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:P70196	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405910|imex:IM-16577-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|agonist:"IL-1 (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:9E4912C7825D8197|rigid:nE5dzR3qHy9QUgQiaY0O17Hd2Iw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q86VP1-2	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-5261409|ensembl:ENSP00000265393|ensembl:ENSP00000444811	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:q86vp1-2(display_long)|uniprotkb:TXBP151-L(isoform synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405910|imex:IM-16577-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	intact:EBI-529518(isoform-parent)|uniprotkb:Q86VP1-2(isoform-parent)|ensembl:ENSG00000106052(gene)|ensembl:ENST00000265393(transcript)|ensembl:ENST00000543117(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|agonist:"IL-1 (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:iB5yOObdvhrQlcIqhxAL0O49/T09606	intact-crc:9E4912C7825D8197|rigid:nE5dzR3qHy9QUgQiaY0O17Hd2Iw	false	-	mutation disrupting interaction:624-624|flag tag:?-?|mutation disrupting interaction:593-593|mutation disrupting interaction:624-624,593-593	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QYK7	uniprotkb:Q8C863	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405910|imex:IM-16577-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|agonist:"IL-1 (15min)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	intact-crc:9E4912C7825D8197|rigid:nE5dzR3qHy9QUgQiaY0O17Hd2Iw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60769	uniprotkb:Q60855	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405945|imex:IM-16577-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|agonist:TNF|comment:interaction not detected in Ikka null MEFs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	intact-crc:DD2193E778F3ADA5|rigid:zsdZ78Kib+R8U/CrIVAKq/J5jzg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8C863	uniprotkb:Q3UKC1	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405951|imex:IM-16577-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B, 6C, 6D|agonist:TNF,  IL-1|comment:interaction not detected in Ikka null MEFs.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	intact-crc:CA8C47FF2F91EEC7|rigid:SQDXorN74KWhxoDgBy0Pp8eVQQE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UKC1	uniprotkb:Q60769	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405957|imex:IM-16577-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	agonist:IL-1|figure legend:Fig. 6D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	intact-crc:A158DD334097CE32|rigid:F/Z+nxwbjrZoyDndT9VFF3yijGw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60855	uniprotkb:Q8C863	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4405961|imex:IM-16577-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|agonist:TNF|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	intact-crc:A80C76B46550B0F1|rigid:crivHW/HXlU6nN4Z0oS8wRD24R0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60680	uniprotkb:Q3UKC1	intact:EBI-646245|uniprotkb:Q80VU2|uniprotkb:Q9D2X3	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	psi-mi:ikka_mouse(display_long)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shembade et al. (2011)	pubmed:21765415|imex:IM-16577	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324979|imex:IM-16577-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29719N|mint:Q60680|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-198323|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007595"(lactation)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	psi-mi:"MI:0469"(intact)	-	-	figure legend:8c|antagonist:Tax|agonist:TNF and IL-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2011/09/11	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	intact-crc:BD3D80F3740DEA15|rigid:VDDFUmFNIpb+b7wV0Vey+TJQX3s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)