#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A1S3N8	uniprotkb:P01317	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	intact:EBI-3989070	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:ins_bovin(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016426|mint:MINT-8194473	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194476(identity)	dip:DIP-52901N|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007631"(feeding behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032094"(response to food)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035938"(estradiol secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0060416"(response to growth hormone)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1903524"(positive regulation of blood circulation)|go:"GO:1903544"(response to butyrate)|go:"GO:1903576"(response to L-arginine)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1APH|rcsb pdb:1BPH|rcsb pdb:1CPH|rcsb pdb:1DPH|rcsb pdb:1HO0|rcsb pdb:1PID|rcsb pdb:2A3G|rcsb pdb:2BN1|rcsb pdb:2BN3|rcsb pdb:2INS|rcsb pdb:2ZP6|rcsb pdb:4BS3|rcsb pdb:4E7T|rcsb pdb:4E7U|rcsb pdb:4E7V|rcsb pdb:4I5Y|rcsb pdb:4I5Z|rcsb pdb:4IDW|rcsb pdb:4IHN|rcsb pdb:4M4F|rcsb pdb:4M4H|rcsb pdb:4M4I|rcsb pdb:4M4J|rcsb pdb:4M4L|rcsb pdb:4M4M|rcsb pdb:5AZZ|rcsb pdb:5KQV|rcsb pdb:5MIZ|rcsb pdb:6KH9|rcsb pdb:6KHA|rcsb pdb:6OR0|rcsb pdb:6Q8Q|rcsb pdb:6QQ7|rcsb pdb:6QQG|rcsb pdb:6QRH|rcsb pdb:6QRK|rcsb pdb:6ZHB|rcsb pdb:6ZI8|rcsb pdb:7ELJ|rcsb pdb:6KH8|mint:MINT-8194475(identity)	-	comment:mint	-	figure legend:t1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	rogid:CgQ4BPd2mlhYt73TJXbE6V9GJYs9913	intact-crc:60476F166389523A|rigid:PsZUuF9RX+tU6PUeCLu+0XdGuAI	false	his tag:?-?(MINT-8194478)	uncategorized protein modification:39-39(MINT-8194486)|binding-associated region:25-54(MINT-8194484)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:A1S3N8	uniprotkb:P01317	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	intact:EBI-3989070	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:ins_bovin(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016446|mint:MINT-8194489	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194491(identity)	dip:DIP-52901N|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007631"(feeding behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032094"(response to food)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035938"(estradiol secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0060416"(response to growth hormone)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1903524"(positive regulation of blood circulation)|go:"GO:1903544"(response to butyrate)|go:"GO:1903576"(response to L-arginine)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1APH|rcsb pdb:1BPH|rcsb pdb:1CPH|rcsb pdb:1DPH|rcsb pdb:1HO0|rcsb pdb:1PID|rcsb pdb:2A3G|rcsb pdb:2BN1|rcsb pdb:2BN3|rcsb pdb:2INS|rcsb pdb:2ZP6|rcsb pdb:4BS3|rcsb pdb:4E7T|rcsb pdb:4E7U|rcsb pdb:4E7V|rcsb pdb:4I5Y|rcsb pdb:4I5Z|rcsb pdb:4IDW|rcsb pdb:4IHN|rcsb pdb:4M4F|rcsb pdb:4M4H|rcsb pdb:4M4I|rcsb pdb:4M4J|rcsb pdb:4M4L|rcsb pdb:4M4M|rcsb pdb:5AZZ|rcsb pdb:5KQV|rcsb pdb:5MIZ|rcsb pdb:6KH9|rcsb pdb:6KHA|rcsb pdb:6OR0|rcsb pdb:6Q8Q|rcsb pdb:6QQ7|rcsb pdb:6QQG|rcsb pdb:6QRH|rcsb pdb:6QRK|rcsb pdb:6ZHB|rcsb pdb:6ZI8|rcsb pdb:7ELJ|rcsb pdb:6KH8|mint:MINT-8194495(identity)	-	comment:mint	-	figure legend:t1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	rogid:CgQ4BPd2mlhYt73TJXbE6V9GJYs9913	intact-crc:195A785F574F41BE|rigid:PsZUuF9RX+tU6PUeCLu+0XdGuAI	false	his tag:?-?(MINT-8194492)	uncategorized protein modification:40-40(MINT-8194496)|binding-associated region:25-54(MINT-8194498)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:A1S3N8	intact:EBI-7016466	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	intact:MINT-8194518	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:cdr1 peptide(display_short)|psi-mi:EBI-7016466(display_long)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016488|mint:MINT-8194525	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194527(identity)	mint:MINT-8194531(identity)	-	comment:mint	comment:mint|no-uniprot-update:	figure legend:t1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	rogid:UovFlUsi0x/+mv/acWe2wqRvCxU-2	intact-crc:40C711811332205C|rigid:9oiyz/M+8Y9DcSKA4jxEfnTuhTI	false	his tag:?-?(MINT-8194528)	uncategorized protein modification:8-8(MINT-8194532)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:A1S3N8	intact:EBI-7016466	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	intact:MINT-8194518	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:cdr1 peptide(display_short)|psi-mi:EBI-7016466(display_long)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016471|mint:MINT-8194504	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194506(identity)	mint:MINT-8194520(identity)	-	comment:mint	comment:mint|no-uniprot-update:	figure legend:t1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	rogid:UovFlUsi0x/+mv/acWe2wqRvCxU-2	intact-crc:0E76545DE035BEEF|rigid:9oiyz/M+8Y9DcSKA4jxEfnTuhTI	false	his tag:?-?(MINT-8194507)	uncategorized protein modification:7-7(MINT-8194522)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:A1S3N8	intact:EBI-7016509	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	intact:MINT-8194549	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:synthetic fluorogeni(display_short)|psi-mi:EBI-7016509(display_long)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016505|mint:MINT-8194537	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194539(identity)	mint:MINT-8194551(identity)	-	comment:mint	comment:mint|no-uniprot-update:	comment:mint|figure legend:t1 f4	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	rogid:pED8wjQXO/ZtP5mP8qjnKaTlAHc-2	intact-crc:EBB276EF08E40416|rigid:JM5S/tPhlH7C/0YsfGiY9S8kni4	false	his tag:?-?(MINT-8194540)|mutation disrupting interaction:37-37(MINT-8194557)	uncategorized protein modification:6-6(MINT-8194553)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-7016509	uniprotkb:A1S3N8	intact:MINT-8194549	intact:EBI-7016414|ensemblbacteria:ABL98994|intact:MINT-8194462	psi-mi:synthetic fluorogeni(display_short)|psi-mi:EBI-7016509(display_long)	psi-mi:a1s3n8_sheam(display_long)|uniprotkb:Sama_0787(locus name)	psi-mi:"MI:0435"(protease assay)	Simões et al. (2011)	pubmed:21749650|mint:MINT-8194455|doi:10.1111/j.1742-4658.2011.08243	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:326297(sheam)|taxid:326297("Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7016531|mint:MINT-8194561	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	mint:MINT-8194569(identity)	interpro:IPR033121|ensemblbacteria:ABL98994(transcript)|ensemblbacteria:Sama_0787(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034164|mint:MINT-8194563(identity)	-	comment:mint|no-uniprot-update:	comment:mint	comment:mint|figure legend:t1 f4	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/06	2014/10/16	rogid:pED8wjQXO/ZtP5mP8qjnKaTlAHc-2	rogid:Y1sUC6fY33kS4VEYcr/Cn696J08326297	intact-crc:0B69066D1417DFF9|rigid:JM5S/tPhlH7C/0YsfGiY9S8kni4	false	uncategorized protein modification:7-7(MINT-8194570)	his tag:?-?(MINT-8194566)|mutation disrupting interaction:37-37(MINT-8194564)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)