#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15208	uniprotkb:Q3UHD9	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chan et al. (2011)	pubmed:21720388|imex:IM-15879|mint:MINT-8203534|doi:10.1038/embor.2011.108	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6999010|mint:MINT-8203542|imex:IM-15879-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N|mint:MINT-8203545(identity)	refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)|mint:MINT-8203544(identity)	-	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-liver)|taxid:10090(Mus musculus)	-	2011/09/07	2014/10/16	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090	intact-crc:614FB08339A73003|rigid:/2/QszKBrp2DdIlY1KtaAQnlmc0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213	uniprotkb:Q99490	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chan et al. (2011)	pubmed:21720388|imex:IM-15879|mint:MINT-8203534|doi:10.1038/embor.2011.108	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6999123|mint:MINT-8204673|imex:IM-15879-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7|mint:MINT-8204676(identity)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|mint:MINT-8204675(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf5a sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/07	2014/10/16	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	intact-crc:8ECBF3F5C20B52B0|rigid:wF7qIyGNsV2xnNRn6zxdsylGFqY	false	myc tag:?-?(MINT-8204683)|binding-associated region:1292-1370(MINT-8204686)	glutathione s tranferase tag:?-?(MINT-8204679)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99490	uniprotkb:P06213	intact:EBI-2361824|uniprotkb:O00578|uniprotkb:Q548E0|uniprotkb:Q8IWU3|uniprotkb:A8K9F7	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	psi-mi:agap2_human(display_long)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chan et al. (2011)	pubmed:21720388|imex:IM-15879|mint:MINT-8203534|doi:10.1038/embor.2011.108	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6999168|mint:MINT-8204689|imex:IM-15879-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116244.1|refseq:NP_055585.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:2BMJ|rcsb pdb:2IWR|rcsb pdb:2RLO|interpro:IPR037278|interpro:IPR038508|interpro:IPR027417|interpro:IPR001806(Ras GTPase)|reactome:R-HSA-373752|interpro:IPR036770|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|mint:MINT-8204691(identity)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7|mint:MINT-8204695(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf5a sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/07	2014/10/16	rogid:8/lz/H3aXs+maU1J2TTJbV7DpKc9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	intact-crc:CA8E52B5F7E474D4|rigid:wF7qIyGNsV2xnNRn6zxdsylGFqY	false	glutathione s tranferase tag:?-?(MINT-8204692)	binding-associated region:1292-1370(MINT-8204696)|myc tag:?-?(MINT-8204698)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)