#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q24008 uniprotkb:Q9W2S5 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-121784|ensemblmetazoa:FBpp0071422 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:q9w2s5_drome(display_long)|uniprotkb:X11Lbeta(gene name)|psi-mi:X11Lbeta(display_short)|uniprotkb:CG1852(gene name synonym)|uniprotkb:CG1861(gene name synonym)|uniprotkb:Dmel\CG32677(gene name synonym)|uniprotkb:Dmint2(gene name synonym)|uniprotkb:X11B(gene name synonym)|uniprotkb:x11Lbeta(gene name synonym)|uniprotkb:Dmel_CG32677(orf name)|uniprotkb:CG32677(orf name)|uniprotkb:X11LB(gene name synonym)|uniprotkb:X11lbeta(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307020|imex:IM-16552-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 refseq:NP_727440.3|flybase:FBgn0052677|ensemblmetazoa:FBgn0052677(gene)|ensemblmetazoa:FBtr0071493(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0043197"(dendritic spine)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036034|reactome:R-DME-212676|dip:DIP-23456N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:5.04x10^-4(molar) 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:rpd8XDYa+ae37Lf7+Z1yBVRWocE7227 intact-crc:80AEF66B041AD745|rigid:bXiIRapfaFyyOoByoPQDdTAdhJw false sufficient binding region:580-665 sufficient binding region:2131-2139 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19334 uniprotkb:Q24008 intact:EBI-165136|uniprotkb:Q7YU76|uniprotkb:Q9VAE1|ensemblmetazoa:FBpp0084879 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:trp_drome(display_long)|uniprotkb:trp(gene name)|psi-mi:trp(display_short)|uniprotkb:CG7875(orf name) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307161|imex:IM-16552-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476768.1|flybase:FBgn0003861|ensemblmetazoa:FBgn0003861(gene)|ensemblmetazoa:FBtr0085513(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008355"(olfactory learning)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010461"(light-activated ion channel activity)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0034703"(cation channel complex)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071454"(cellular response to anoxia)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5F67|rcsb pdb:7CQH|rcsb pdb:7CQV|reactome:R-DME-114508|reactome:R-DME-139853|reactome:R-DME-3295583|reactome:R-DME-5578775|reactome:R-DME-983695 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.4x10^-6(molar) 2011/07/19 2014/10/16 rogid:CZ/nZUylQKoS0GQ3jKaucCw8gjo7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:F22F215B26D9419A|rigid:yKZ8+as1sCVyTMyv69MfpUkf70o false sufficient binding region:1267-1275 sufficient binding region:473-674 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A3RLX3 uniprotkb:Q24008 intact:EBI-4306640 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:a3rlx3_drome(display_long)|uniprotkb:Kon(gene name)|psi-mi:Kon(display_short) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307022|imex:IM-16552-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0016021"(integral component of membrane) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Figs. 1A, 1B, 5F, 5G, Supp. Fig. 4A|comment:Binding is not affected by a change in pH from 7.5 to 5.8.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-6(molar) 2011/07/19 2014/10/16 rogid:ZQX0NV75g0U9isGnAnHcPRo4hvg7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:CCB1635C9EB61A60|rigid:f7BcNaXT3LDG875aicyEyPwPgMM false sufficient binding region:2372-2381 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13217 uniprotkb:Q24008 intact:EBI-101510|uniprotkb:Q9U4G4|uniprotkb:Q9W4K9|intact:EBI-496262|uniprotkb:A4V3Y2|uniprotkb:Q59E70|uniprotkb:Q86P93|ensemblmetazoa:FBpp0070618|ensemblmetazoa:FBpp0070619|ensemblmetazoa:FBpp0290690 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:pipa_drome(display_long)|uniprotkb:norpA(gene name)|psi-mi:norpA(display_short)|uniprotkb:Phosphoinositide phospholipase C(gene name synonym)|uniprotkb:No receptor potential A protein(gene name synonym)|uniprotkb:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta(gene name synonym)|uniprotkb:PLC-beta(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-beta(gene name synonym)|uniprotkb:CG3620(orf name) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4373471|imex:IM-16552-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001284860.1|refseq:NP_001014720.1|refseq:NP_001014721.1|refseq:NP_001162661.1|refseq:NP_525069.2|refseq:NP_726925.1|flybase:FBgn0262738|rcsb pdb:6IRE|reactome:R-DME-112043|reactome:R-DME-1855204|reactome:R-DME-416476|rcsb pdb:6IRC|ensemblmetazoa:FBtr0070650(transcript)|ensemblmetazoa:FBtr0070651(transcript)|ensemblmetazoa:FBtr0301475(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0043052"(thermotaxis)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|interpro:IPR011992(EF-Hand type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|ensemblmetazoa:FBgn0262738(gene)|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|rcsb pdb:1IHJ|rcsb pdb:6IRB|dip:DIP-45N refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 6C|comment:norpA will bind to the PDZ5 domain of inad but with a Kd=30uM. The oxidation of PDZ45 abolished its binding to the norpA peptide|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.0x10^-5(molar) 2011/07/19 2014/10/16 rogid:Esq1IaXfd/xa+Zn1DzA0MIQN/VM7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:D117C364DA56E0DD|rigid:VR0fqNrtzxzZ70l6H6inif+yG7g false sufficient binding region:1086-1095 sufficient binding region:473-674 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:P19334 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-165136|uniprotkb:Q7YU76|uniprotkb:Q9VAE1|ensemblmetazoa:FBpp0084879 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:trp_drome(display_long)|uniprotkb:trp(gene name)|psi-mi:trp(display_short)|uniprotkb:CG7875(orf name) psi-mi:"MI:0096"(pull down) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307207|imex:IM-16552-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 refseq:NP_476768.1|flybase:FBgn0003861|ensemblmetazoa:FBgn0003861(gene)|ensemblmetazoa:FBtr0085513(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008355"(olfactory learning)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010461"(light-activated ion channel activity)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0034703"(cation channel complex)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071454"(cellular response to anoxia)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5F67|rcsb pdb:7CQH|rcsb pdb:7CQV|reactome:R-DME-114508|reactome:R-DME-139853|reactome:R-DME-3295583|reactome:R-DME-5578775|reactome:R-DME-983695 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:CZ/nZUylQKoS0GQ3jKaucCw8gjo7227 intact-crc:A15644A1A7D895DB|rigid:yKZ8+as1sCVyTMyv69MfpUkf70o false - mutation disrupting interaction:1274-1274,1266-1266|mutation decreasing interaction:1266-1266|glutathione s tranferase tag:?-?|sufficient binding region:1261-1275 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q24008 uniprotkb:Q00657 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-4306655 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:cspg4_rat(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:HSN tumor-specific antigen(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307053|imex:IM-16552-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 rgd:619942|refseq:NP_112284.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0097178"(ruffle assembly)|go:"GO:0005518"(collagen binding)|reactome:R-RNO-1971475|reactome:R-RNO-2022870|reactome:R-RNO-2022923|reactome:R-RNO-2024101 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.2x10^-6(molar) 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:CfGifYzmU0TPzp2pisYzH8/HlCo10116 intact-crc:D0351FADEF518223|rigid:1FvER4FyCaSoo7z0wbk62dsilGY false sufficient binding region:580-665 sufficient binding region:2318-2326 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:Q9JLB9 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-4306755|uniprotkb:Q059N7|uniprotkb:Q9D006|uniprotkb:Q9JLB7|uniprotkb:Q9JLB8|ensembl:ENSMUSP00000023334 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:nect3_mouse(display_long)|uniprotkb:Nectin3(gene name)|psi-mi:Nectin3(display_short)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym)|uniprotkb:Pvrl3(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307051|imex:IM-16552-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 refseq:NP_067470.1|refseq:NP_067471.1|refseq:NP_067472.1|ensembl:ENSMUSG00000022656(gene)|ensembl:ENSMUST00000023334(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045202"(synapse)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:3AXA|rcsb pdb:5B22|reactome:R-MMU-418990|reactome:R-MMU-420597|dip:DIP-41729N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-4(molar) 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:hF88tJa0izs2SsJboxVJUyuKRfE10090 intact-crc:A6DBE11515196A9F|rigid:asjY9Ohg8hOT59JZuc7ByyiDHG8 false sufficient binding region:580-665 sufficient binding region:540-549 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63372 uniprotkb:Q24008 intact:EBI-4306702 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:nrx1a_rat(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307049|imex:IM-16552-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3BIW|rgd:628659|refseq:NP_068535.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009986"(cell surface)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030534"(adult behavior)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042297"(vocal learning)|go:"GO:0042551"(neuron maturation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090126"(protein-containing complex assembly involved in synapse maturation)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|reactome:R-RNO-6794361 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.2x10^-5(molar) 2011/07/19 2014/10/16 rogid:HEfcQbUgD2+JA2E3Bl7zAPP8/I010116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:DAC6C0296CD2A463|rigid:CNKYFFi4rrjkLQRMO2ip59nT+Mc false sufficient binding region:1522-1530 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:O35430 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-704760 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:apba1_rat(display_long)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Apba1(gene name)|psi-mi:Apba1(display_short)|uniprotkb:Mint1(gene name synonym)|uniprotkb:X11(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307047|imex:IM-16552-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 rgd:620844|refseq:NP_113967.1|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR030530|mint:O35430|interpro:IPR036034|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:4DBB|rcsb pdb:6KMH|reactome:R-RNO-212676 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:ybffWeGU/EFTeYx031rgcwPB2w410116 intact-crc:83CB830F7919306B|rigid:zQS+eYPfJqxLmUQ3+qc+dy0uBjo false sufficient binding region:580-665 sufficient binding region:831-839 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9JHY1 uniprotkb:Q24008 intact:EBI-4306794|ensembl:ENSRNOP00000006141 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:jam1_rat(display_long)|uniprotkb:F11r(gene name)|psi-mi:F11r(display_short)|uniprotkb:Jam1(gene name synonym)|uniprotkb:Junctional adhesion molecule 1(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307055|imex:IM-16552-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621842|refseq:NP_446248.1|ensembl:ENSRNOG00000004414(gene)|ensembl:ENSRNOT00000006141(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042456|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2173791|reactome:R-RNO-420029 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.4x10^-4(molar) 2011/07/19 2014/10/16 rogid:d17EpU0Uri8XpvdNExC4FW+k03Q10116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:1F28091C352E1FA8|rigid:3MzX0Ttvfm9aUMemC5Yk2dfzbEo false sufficient binding region:291-300 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19334 uniprotkb:Q24008 intact:EBI-165136|uniprotkb:Q7YU76|uniprotkb:Q9VAE1|ensemblmetazoa:FBpp0084879 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:trp_drome(display_long)|uniprotkb:trp(gene name)|psi-mi:trp(display_short)|uniprotkb:CG7875(orf name) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0071"(molecular sieving) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307183|imex:IM-16552-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476768.1|flybase:FBgn0003861|ensemblmetazoa:FBgn0003861(gene)|ensemblmetazoa:FBtr0085513(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008355"(olfactory learning)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010461"(light-activated ion channel activity)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0034703"(cation channel complex)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071454"(cellular response to anoxia)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5F67|rcsb pdb:7CQH|rcsb pdb:7CQV|reactome:R-DME-114508|reactome:R-DME-139853|reactome:R-DME-3295583|reactome:R-DME-5578775|reactome:R-DME-983695 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:CZ/nZUylQKoS0GQ3jKaucCw8gjo7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:E0945514CB614BD5|rigid:yKZ8+as1sCVyTMyv69MfpUkf70o false sufficient binding region:1261-1275|tag:?-? sufficient binding region:364..364-674 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A3RLX3 uniprotkb:Q24008 intact:EBI-4306640 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:a3rlx3_drome(display_long)|uniprotkb:Kon(gene name)|psi-mi:Kon(display_short) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306617|imex:IM-16552-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0016021"(integral component of membrane) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:ZQX0NV75g0U9isGnAnHcPRo4hvg7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:A293C2FB30936335|rigid:f7BcNaXT3LDG875aicyEyPwPgMM false sufficient binding region:2372-2381 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9W2S5 uniprotkb:Q24008 intact:EBI-121784|ensemblmetazoa:FBpp0071422 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:q9w2s5_drome(display_long)|uniprotkb:X11Lbeta(gene name)|psi-mi:X11Lbeta(display_short)|uniprotkb:CG1852(gene name synonym)|uniprotkb:CG1861(gene name synonym)|uniprotkb:Dmel\CG32677(gene name synonym)|uniprotkb:Dmint2(gene name synonym)|uniprotkb:X11B(gene name synonym)|uniprotkb:x11Lbeta(gene name synonym)|uniprotkb:Dmel_CG32677(orf name)|uniprotkb:CG32677(orf name)|uniprotkb:X11LB(gene name synonym)|uniprotkb:X11lbeta(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307005|imex:IM-16552-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_727440.3|flybase:FBgn0052677|ensemblmetazoa:FBgn0052677(gene)|ensemblmetazoa:FBtr0071493(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0043197"(dendritic spine)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036034|reactome:R-DME-212676|dip:DIP-23456N refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:rpd8XDYa+ae37Lf7+Z1yBVRWocE7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:3BAEC5C0F43EE3E2|rigid:bXiIRapfaFyyOoByoPQDdTAdhJw false sufficient binding region:2131-2139 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35430 uniprotkb:Q24008 intact:EBI-704760 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:apba1_rat(display_long)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Apba1(gene name)|psi-mi:Apba1(display_short)|uniprotkb:Mint1(gene name synonym)|uniprotkb:X11(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306819|imex:IM-16552-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620844|refseq:NP_113967.1|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR030530|mint:O35430|interpro:IPR036034|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:4DBB|rcsb pdb:6KMH|reactome:R-RNO-212676 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:ybffWeGU/EFTeYx031rgcwPB2w410116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:E63BEADB24173B49|rigid:zQS+eYPfJqxLmUQ3+qc+dy0uBjo false sufficient binding region:831-839 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9JHY1 uniprotkb:Q24008 intact:EBI-4306794|ensembl:ENSRNOP00000006141 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:jam1_rat(display_long)|uniprotkb:F11r(gene name)|psi-mi:F11r(display_short)|uniprotkb:Jam1(gene name synonym)|uniprotkb:Junctional adhesion molecule 1(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306792|imex:IM-16552-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621842|refseq:NP_446248.1|ensembl:ENSRNOG00000004414(gene)|ensembl:ENSRNOT00000006141(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042456|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2173791|reactome:R-RNO-420029 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:d17EpU0Uri8XpvdNExC4FW+k03Q10116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:AB91CCCE6E7B459E|rigid:3MzX0Ttvfm9aUMemC5Yk2dfzbEo false sufficient binding region:291-300 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63372 uniprotkb:Q24008 intact:EBI-4306702 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:nrx1a_rat(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306700|imex:IM-16552-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3BIW|rgd:628659|refseq:NP_068535.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009986"(cell surface)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030534"(adult behavior)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042297"(vocal learning)|go:"GO:0042551"(neuron maturation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090126"(protein-containing complex assembly involved in synapse maturation)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|reactome:R-RNO-6794361 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:HEfcQbUgD2+JA2E3Bl7zAPP8/I010116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:4A4496D135C42392|rigid:CNKYFFi4rrjkLQRMO2ip59nT+Mc false sufficient binding region:1522-1530 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00657 uniprotkb:Q24008 intact:EBI-4306655 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:cspg4_rat(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:HSN tumor-specific antigen(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306683|imex:IM-16552-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:619942|refseq:NP_112284.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0097178"(ruffle assembly)|go:"GO:0005518"(collagen binding)|reactome:R-RNO-1971475|reactome:R-RNO-2022870|reactome:R-RNO-2022923|reactome:R-RNO-2024101 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:CfGifYzmU0TPzp2pisYzH8/HlCo10116 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:380E84BA62B6C5F9|rigid:1FvER4FyCaSoo7z0wbk62dsilGY false sufficient binding region:2318-2326 sufficient binding region:580-665 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:Q9JLB9 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-4306755|uniprotkb:Q059N7|uniprotkb:Q9D006|uniprotkb:Q9JLB7|uniprotkb:Q9JLB8|ensembl:ENSMUSP00000023334 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:nect3_mouse(display_long)|uniprotkb:Nectin3(gene name)|psi-mi:Nectin3(display_short)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym)|uniprotkb:Pvrl3(gene name synonym) psi-mi:"MI:0081"(peptide array) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4306753|imex:IM-16552-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 refseq:NP_067470.1|refseq:NP_067471.1|refseq:NP_067472.1|ensembl:ENSMUSG00000022656(gene)|ensembl:ENSMUST00000023334(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045202"(synapse)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:3AXA|rcsb pdb:5B22|reactome:R-MMU-418990|reactome:R-MMU-420597|dip:DIP-41729N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:hF88tJa0izs2SsJboxVJUyuKRfE10090 intact-crc:126224C74E4C30A9|rigid:asjY9Ohg8hOT59JZuc7ByyiDHG8 false sufficient binding region:580-665 sufficient binding region:540-549 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:Q00657 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-4306655 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:cspg4_rat(display_long)|uniprotkb:Cspg4(gene name)|psi-mi:Cspg4(display_short)|uniprotkb:Ng2(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan NG2(gene name synonym)|uniprotkb:HSN tumor-specific antigen(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307107|imex:IM-16552-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 rgd:619942|refseq:NP_112284.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0097178"(ruffle assembly)|go:"GO:0005518"(collagen binding)|reactome:R-RNO-1971475|reactome:R-RNO-2022870|reactome:R-RNO-2022923|reactome:R-RNO-2024101 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 2|3d-resolution:2.6A|3d-r-factors:Rworking=19.8% Rfree=26.3%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:CfGifYzmU0TPzp2pisYzH8/HlCo10116 intact-crc:04607754912D0439|rigid:1FvER4FyCaSoo7z0wbk62dsilGY false sufficient binding region:473-674 sufficient binding region:2318-2326 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:A3RLX3 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-4306640 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:a3rlx3_drome(display_long)|uniprotkb:Kon(gene name)|psi-mi:Kon(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307126|imex:IM-16552-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001791(Laminin G)|interpro:IPR039005|go:"GO:0016021"(integral component of membrane) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Figs. 1, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:ZQX0NV75g0U9isGnAnHcPRo4hvg7227 intact-crc:109B2C7D94180A70|rigid:f7BcNaXT3LDG875aicyEyPwPgMM false sufficient binding region:580-665 15n label:?-?|sufficient binding region:2372-2381 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24008 uniprotkb:P19334 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 intact:EBI-165136|uniprotkb:Q7YU76|uniprotkb:Q9VAE1|ensemblmetazoa:FBpp0084879 psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:trp_drome(display_long)|uniprotkb:trp(gene name)|psi-mi:trp(display_short)|uniprotkb:CG7875(orf name) psi-mi:"MI:0077"(nuclear magnetic resonance) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307169|imex:IM-16552-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 refseq:NP_476768.1|flybase:FBgn0003861|ensemblmetazoa:FBgn0003861(gene)|ensemblmetazoa:FBtr0085513(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008355"(olfactory learning)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010461"(light-activated ion channel activity)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0034703"(cation channel complex)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071454"(cellular response to anoxia)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5F67|rcsb pdb:7CQH|rcsb pdb:7CQV|reactome:R-DME-114508|reactome:R-DME-139853|reactome:R-DME-3295583|reactome:R-DME-5578775|reactome:R-DME-983695 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 rogid:CZ/nZUylQKoS0GQ3jKaucCw8gjo7227 intact-crc:69C083CA674E3E97|rigid:yKZ8+as1sCVyTMyv69MfpUkf70o false sufficient binding region:473-674 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P17252 uniprotkb:Q24008 intact:EBI-1383528|uniprotkb:Q96RE4|uniprotkb:Q15137|uniprotkb:Q32M72|uniprotkb:B5BU22|ensembl:ENSP00000408695 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:kpca_human(display_long)|uniprotkb:PRKCA(gene name)|psi-mi:PRKCA(display_short)|uniprotkb:PKCA(gene name synonym)|uniprotkb:PRKACA(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307253|imex:IM-16552-22 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002728.1|dip:DIP-531N|ensembl:ENSG00000154229(gene)|ensembl:ENST00000413366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|mint:P17252|rcsb pdb:2ELI|rcsb pdb:3IW4|rcsb pdb:4DNL|rcsb pdb:4RA4|reactome:R-HSA-111933|reactome:R-HSA-114516|reactome:R-HSA-1250196|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2179392|reactome:R-HSA-2514859|reactome:R-HSA-3000170|reactome:R-HSA-399997|reactome:R-HSA-4086398|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-4419969|reactome:R-HSA-450520|reactome:R-HSA-5099900|go:"GO:0043488"(regulation of mRNA stability)|reactome:R-HSA-5668599|reactome:R-HSA-76005|reactome:R-HSA-8853659|reactome:R-HSA-9010642|reactome:R-HSA-5218921 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:VW6o9vP7DTAQT2W9hEmyCLjoEX09606 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:1377C5A86F20642B|rigid:EJ72CWzMGdpzdO+pJDgGYogvNi8 false - sufficient binding region:473..473-674..674,249..249-332..332 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P17252 uniprotkb:Q24008 intact:EBI-1383528|uniprotkb:Q96RE4|uniprotkb:Q15137|uniprotkb:Q32M72|uniprotkb:B5BU22|ensembl:ENSP00000408695 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:kpca_human(display_long)|uniprotkb:PRKCA(gene name)|psi-mi:PRKCA(display_short)|uniprotkb:PKCA(gene name synonym)|uniprotkb:PRKACA(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307239|imex:IM-16552-21 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002728.1|dip:DIP-531N|ensembl:ENSG00000154229(gene)|ensembl:ENST00000413366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|mint:P17252|rcsb pdb:2ELI|rcsb pdb:3IW4|rcsb pdb:4DNL|rcsb pdb:4RA4|reactome:R-HSA-111933|reactome:R-HSA-114516|reactome:R-HSA-1250196|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2179392|reactome:R-HSA-2514859|reactome:R-HSA-3000170|reactome:R-HSA-399997|reactome:R-HSA-4086398|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-4419969|reactome:R-HSA-450520|reactome:R-HSA-5099900|go:"GO:0043488"(regulation of mRNA stability)|reactome:R-HSA-5668599|reactome:R-HSA-76005|reactome:R-HSA-8853659|reactome:R-HSA-9010642|reactome:R-HSA-5218921 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:VW6o9vP7DTAQT2W9hEmyCLjoEX09606 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:C7CCDE1747A58F49|rigid:EJ72CWzMGdpzdO+pJDgGYogvNi8 false - sufficient binding region:249..249-332..332 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P13677 uniprotkb:Q24008 intact:EBI-130595|uniprotkb:Q9V7V5|ensemblmetazoa:FBpp0086196 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:kpc2_drome(display_long)|uniprotkb:inaC(gene name)|psi-mi:inaC(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:CG6518(orf name)|uniprotkb:Eye-PKC(gene name synonym)|uniprotkb:Photoreceptor-specific PKC(gene name synonym)|uniprotkb:"dPKC53E(EY)"(gene name synonym)|uniprotkb:Inactivation no after-potential C protein(gene name synonym) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307143|imex:IM-16552-24 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476863.1|flybase:FBgn0004784|ensemblmetazoa:FBgn0004784(gene)|ensemblmetazoa:FBtr0087047(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009416"(response to light stimulus)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0016062"(adaptation of rhodopsin mediated signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045471"(response to ethanol)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|reactome:R-DME-111933|reactome:R-DME-114516|reactome:R-DME-1169091|reactome:R-DME-4419969|reactome:R-DME-5099900|reactome:R-DME-5218921|reactome:R-DME-76005|dip:DIP-54N refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Figs. 5A, 5B|comment:Wild type Inad was not phosphorylated by ePKC, however substitution of Thr669 with Ala, a mutation originally designed to mimic non-phosphorylated state of the residue, led to dramatically increased phosphorylation. Thr513Ala in the PDZ45 interface also led to an increase of its phosphorylation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:foe+SbTNOE16H0jrxgDbyAGKxHk7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:C04F80EA646FF62E|rigid:krhcjrYCf9NJ3fNG8XT18D/yV0U false his tag:?-? mutation:513-513|sufficient binding region:473-674|mutation:669-669 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P13677 - intact:EBI-130595|uniprotkb:Q9V7V5|ensemblmetazoa:FBpp0086196 - psi-mi:kpc2_drome(display_long)|uniprotkb:inaC(gene name)|psi-mi:inaC(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:CG6518(orf name)|uniprotkb:Eye-PKC(gene name synonym)|uniprotkb:Photoreceptor-specific PKC(gene name synonym)|uniprotkb:"dPKC53E(EY)"(gene name synonym)|uniprotkb:Inactivation no after-potential C protein(gene name synonym) - psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4373524|imex:IM-16552-23 - - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0326"(protein) - refseq:NP_476863.1|flybase:FBgn0004784|ensemblmetazoa:FBgn0004784(gene)|ensemblmetazoa:FBtr0087047(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009416"(response to light stimulus)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0016062"(adaptation of rhodopsin mediated signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045471"(response to ethanol)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|reactome:R-DME-111933|reactome:R-DME-114516|reactome:R-DME-1169091|reactome:R-DME-4419969|reactome:R-DME-5099900|reactome:R-DME-5218921|reactome:R-DME-76005|dip:DIP-54N - go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation) - - figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:foe+SbTNOE16H0jrxgDbyAGKxHk7227 - intact-crc:6690F0FDCFAA720B false his tag:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) - uniprotkb:P19334 uniprotkb:Q24008 intact:EBI-165136|uniprotkb:Q7YU76|uniprotkb:Q9VAE1|ensemblmetazoa:FBpp0084879 intact:EBI-195326|uniprotkb:Q9NBV3|ensemblmetazoa:FBpp0071820 psi-mi:trp_drome(display_long)|uniprotkb:trp(gene name)|psi-mi:trp(display_short)|uniprotkb:CG7875(orf name) psi-mi:inad_drome(display_long)|uniprotkb:inaD(gene name)|psi-mi:inaD(display_short)|uniprotkb:CG3504(orf name) psi-mi:"MI:0028"(cosedimentation in solution) Liu et al. (2011) pubmed:21703451|imex:IM-16552 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4307229|imex:IM-16552-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476768.1|flybase:FBgn0003861|ensemblmetazoa:FBgn0003861(gene)|ensemblmetazoa:FBtr0085513(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007602"(phototransduction)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008355"(olfactory learning)|go:"GO:0008377"(light-induced release of internally sequestered calcium ion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010461"(light-activated ion channel activity)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0034703"(cation channel complex)|go:"GO:0035997"(rhabdomere microvillus membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071454"(cellular response to anoxia)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5F67|rcsb pdb:7CQH|rcsb pdb:7CQV|reactome:R-DME-114508|reactome:R-DME-139853|reactome:R-DME-3295583|reactome:R-DME-5578775|reactome:R-DME-983695 refseq:NP_726260.1|flybase:FBgn0001263|dip:DIP-18621N|ensemblmetazoa:FBgn0001263(gene)|ensemblmetazoa:FBtr0071909(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008104"(protein localization)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0016027"(inaD signaling complex)|go:"GO:0016028"(rhabdomere)|go:"GO:0016059"(deactivation of rhodopsin mediated signaling)|go:"GO:0017022"(myosin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031473"(myosin III binding)|go:"GO:0050962"(detection of light stimulus involved in sensory perception)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:1IHJ|rcsb pdb:2LA8|rcsb pdb:2QKT|rcsb pdb:2QKU|rcsb pdb:2QKV|rcsb pdb:3R0H|rcsb pdb:5F67|rcsb pdb:6IRE|reactome:R-DME-983168 psi-mi:"MI:0469"(intact) - - figure legend:Supp Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/19 2014/10/16 rogid:CZ/nZUylQKoS0GQ3jKaucCw8gjo7227 rogid:A8GcGpwkZoLFwA/GoYkveOsUzC07227 intact-crc:69C91DBB15460BD2|rigid:yKZ8+as1sCVyTMyv69MfpUkf70o false tag:?-?|sufficient binding region:1261-1275 sufficient binding region:364..364-674 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)