#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14222	uniprotkb:P14222	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Thiery et al. (2011)	pubmed:21685908|imex:IM-15820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4310418|imex:IM-15820-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G, S5D|comment:oligomer band migrated at ~420kDa, which is the estimated weight of a hepatmer. A larger band was also observed, suggesting the formation of a larger multimer.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2011/07/26	2014/10/16	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	intact-crc:3E4B3E37841F0AB1|rigid:dfbBjcf+a4MLRcCuHMnszmpilEc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15075	uniprotkb:P10144	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Thiery et al. (2011)	pubmed:21685908|imex:IM-15820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4312295|imex:IM-15820-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	go:"GO:0005829"(cytosol)	-	-	figure legend:Fig. 4A.|agonist:rat perforin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/07/26	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	intact-crc:C65C426F86167EDD|rigid:2vaq37TbsGSwkOMcIab6QslVFrk	false	red fluorescent protein tag:?-?	alexa label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q15075	uniprotkb:Q9UJ41	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-913954|uniprotkb:B4DZM7|uniprotkb:Q3HKR2|uniprotkb:Q3HKR3|uniprotkb:Q53FG0|ensembl:ENSP00000284957|ensembl:ENSP00000415815	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:rabx5_human(display_long)|uniprotkb:Rabex-5(gene name synonym)|uniprotkb:Rabaptin-5-associated exchange factor for Rab5(gene name synonym)|uniprotkb:RAP1(gene name synonym)|uniprotkb:RABGEF1(gene name)|psi-mi:RABGEF1(display_short)|uniprotkb:RABEX5(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Thiery et al. (2011)	pubmed:21685908|imex:IM-15820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-4312305|imex:IM-15820-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2	ensembl:ENSG00000154710(gene)|ensembl:ENST00000284957(transcript)|ensembl:ENST00000450873(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0055037"(recycling endosome)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR037191|interpro:IPR041545|rcsb pdb:1TXU|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2OT3|rcsb pdb:4N3X|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|reactome:R-HSA-8876198|refseq:NP_055319.1|refseq:NP_001273989.1|refseq:NP_001273990.1|refseq:NP_001273991.1|dip:DIP-29348N	go:"GO:0005829"(cytosol)	-	-	figure legend:Fig. S2A|agonist:rat perforin|comment:"Co-transfection of HeLa cells with EGFP-Rab5(Q79L) and mRFP-EEA1 results in enlarged endosomes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/07/26	2019/05/28	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:+MNigZ2IH2ogPAFA5YTYT0rGWYg9606	intact-crc:8916357319D3C78C|rigid:p7+jq8rKZNcFbt7z0sY3MGyyh6M	false	red fluorescent protein tag:?-?	mutation decreasing interaction:?-?|mutation increasing interaction:79-79	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)