#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977169|mint:MINT-8210333|imex:IM-16319-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210335(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8210336(identity) - - - comment:homomint|comment:mint|figure legend:f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:5466050E1A293C3A|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false flag tag:?-?(MINT-8210338) myc tag:?-?(MINT-8295725)|mutation disrupting interaction:195-205(MINT-8295737) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977264|mint:MINT-8210344|imex:IM-16319-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210346(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8210350(identity) - - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:16A0A1BD940B730B|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false flag tag:?-?(MINT-8210347) ha tag:?-?(MINT-8295720) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977282|mint:MINT-8210370|imex:IM-16319-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210372(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8210376(identity) - - - figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:B7906F32C6471DA5|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false flag tag:?-?(MINT-8210373) myc tag:?-?(MINT-8210380) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15013 uniprotkb:Q562F6 intact:EBI-712181|ensembl:ENSP00000361244|uniprotkb:B4DLV3|uniprotkb:Q6IBB1|uniprotkb:E9PAT7 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 psi-mi:md2bp_human(display_long)|uniprotkb:Caught by MAD2 protein(gene name synonym)|uniprotkb:MAD2L1BP(gene name)|psi-mi:MAD2L1BP(display_short)|uniprotkb:CMT2(gene name synonym)|uniprotkb:KIAA0110(gene name synonym)|uniprotkb:"p31(comet)"(gene name synonym) psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977332|mint:MINT-8211761|imex:IM-16319-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003690.1|refseq:NP_055443.1|ensembl:ENSG00000124688(gene)|ensembl:ENST00000372171(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0031965"(nuclear membrane)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR009511(MAD2L1 binding protein)|rcsb pdb:2QYF|rcsb pdb:6F0X|dip:DIP-34492N|mint:MINT-8211778(identity) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8211763(identity) - - - figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:LDtsULnHHfO9LVyGU4PtVTvF/OE9606 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 intact-crc:6103164F82017CA3|rigid:ykTRIvODf9paUFdfUjh8uhpj0uY false flag tag:?-?(MINT-8211783) myc tag:?-?(MINT-8211764) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15013 uniprotkb:Q13257 intact:EBI-712181|ensembl:ENSP00000361244|uniprotkb:B4DLV3|uniprotkb:Q6IBB1|uniprotkb:E9PAT7 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:md2bp_human(display_long)|uniprotkb:Caught by MAD2 protein(gene name synonym)|uniprotkb:MAD2L1BP(gene name)|psi-mi:MAD2L1BP(display_short)|uniprotkb:CMT2(gene name synonym)|uniprotkb:KIAA0110(gene name synonym)|uniprotkb:"p31(comet)"(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977332|mint:MINT-8211761|imex:IM-16319-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003690.1|refseq:NP_055443.1|ensembl:ENSG00000124688(gene)|ensembl:ENST00000372171(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0031965"(nuclear membrane)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR009511(MAD2L1 binding protein)|rcsb pdb:2QYF|rcsb pdb:6F0X|dip:DIP-34492N|mint:MINT-8211778(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8211767(identity) - - - figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:LDtsULnHHfO9LVyGU4PtVTvF/OE9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:6103164F82017CA3|rigid:ykTRIvODf9paUFdfUjh8uhpj0uY false flag tag:?-?(MINT-8211783) ha tag:?-?(MINT-8211768) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q15013 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-712181|ensembl:ENSP00000361244|uniprotkb:B4DLV3|uniprotkb:Q6IBB1|uniprotkb:E9PAT7 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2bp_human(display_long)|uniprotkb:Caught by MAD2 protein(gene name synonym)|uniprotkb:MAD2L1BP(gene name)|psi-mi:MAD2L1BP(display_short)|uniprotkb:CMT2(gene name synonym)|uniprotkb:KIAA0110(gene name synonym)|uniprotkb:"p31(comet)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977356|mint:MINT-8211808|imex:IM-16319-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8211810(identity) refseq:NP_001003690.1|refseq:NP_055443.1|ensembl:ENSG00000124688(gene)|ensembl:ENST00000372171(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0031965"(nuclear membrane)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR009511(MAD2L1 binding protein)|rcsb pdb:2QYF|rcsb pdb:6F0X|dip:DIP-34492N|mint:MINT-8211818(identity) - - - figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:LDtsULnHHfO9LVyGU4PtVTvF/OE9606 intact-crc:39EAE438E33D1F93|rigid:7VjVAMCi6ntdzcF2mE0YfxABeLM false myc tag:?-?(MINT-8211811) flag tag:?-?(MINT-8211819) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Z1B5 uniprotkb:Q7TSY8 intact:EBI-2552918|ensembl:ENSMUSP00000098897|ensembl:ENSMUSP00000112304|uniprotkb:Q9JI53 intact:EBI-2552468|ensembl:ENSMUSP00000027202|uniprotkb:Q8C9C4|uniprotkb:Q811I4|uniprotkb:Q9CS55|uniprotkb:Q8CGJ4 psi-mi:md2l1_mouse(display_long)|uniprotkb:Mad2l1(gene name)|psi-mi:Mad2l1(display_short)|uniprotkb:Mad2a(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:sgo2_mouse(display_long)|uniprotkb:Sgo2(gene name)|psi-mi:Sgo2(display_short)|uniprotkb:Sgol2(gene name synonym)|uniprotkb:Sgol2a(gene name synonym)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977427|mint:MINT-8212291|imex:IM-16319-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062372.2|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-2467813|ensembl:ENSMUSG00000029910(gene)|ensembl:ENSMUST00000101343(transcript)|ensembl:ENSMUST00000116605(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q9Z1B5|reactome:R-MMU-141405|reactome:R-MMU-141430|reactome:R-MMU-141444|reactome:R-MMU-174184|reactome:R-MMU-176409|reactome:R-MMU-179409|refseq:XP_006506469.1|mint:MINT-8212294(identity) ensembl:ENSMUST00000027202(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008104"(protein localization)|go:"GO:0010789"(meiotic sister chromatid cohesion involved in meiosis I)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:2000711"(positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q7TSY8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000026039(gene)|refseq:NP_001171338.1|refseq:NP_950172.1|mint:MINT-8212293(identity) - - - figure legend:sf1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:T2SuApPGRno6LWCTPwVqAvQEVZQ10090 rogid:DJjoQ6spU+RxltEduZMJRaCQN6A10090 intact-crc:FF3D03EDE6CB254C|rigid:VICRdXwCVh0C82hHe1Uj9HIxp1k false ha tag:?-?(MINT-8212300) flag tag:?-?(MINT-8212296) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977389|mint:MINT-8211862|imex:IM-16319-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8211864(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8211868(identity) - - - comment:homomint|comment:mint|figure legend:sf2f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:91A6A7659A74E687|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false flag tag:?-?(MINT-8211865) mutation disrupting interaction:195-195(MINT-8212354)|mutation disrupting interaction:114-114(MINT-8212345)|myc tag:?-?(MINT-8212340)|mutation disrupting interaction:109-109(MINT-8212342)|mutation disrupting interaction:170-170(MINT-8212348)|mutation disrupting interaction:178-178(MINT-8212351) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q562F6 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977463|mint:MINT-8212576|imex:IM-16319-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212578(identity) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212582(identity) - - - comment:homomint|comment:mint|figure legend:sf6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 intact-crc:DD95AF28C7AC689C|rigid:qfVjNnwenkqX1w8k5FpSpp72rO8 false flag tag:?-?(MINT-8212579) myc tag:?-?(MINT-8212586) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Z1B5 uniprotkb:Q7TSY8 intact:EBI-2552918|ensembl:ENSMUSP00000098897|ensembl:ENSMUSP00000112304|uniprotkb:Q9JI53 intact:EBI-2552468|ensembl:ENSMUSP00000027202|uniprotkb:Q8C9C4|uniprotkb:Q811I4|uniprotkb:Q9CS55|uniprotkb:Q8CGJ4 psi-mi:md2l1_mouse(display_long)|uniprotkb:Mad2l1(gene name)|psi-mi:Mad2l1(display_short)|uniprotkb:Mad2a(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:sgo2_mouse(display_long)|uniprotkb:Sgo2(gene name)|psi-mi:Sgo2(display_short)|uniprotkb:Sgol2(gene name synonym)|uniprotkb:Sgol2a(gene name synonym)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977445|mint:MINT-8212304|imex:IM-16319-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062372.2|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-2467813|ensembl:ENSMUSG00000029910(gene)|ensembl:ENSMUST00000101343(transcript)|ensembl:ENSMUST00000116605(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q9Z1B5|reactome:R-MMU-141405|reactome:R-MMU-141430|reactome:R-MMU-141444|reactome:R-MMU-174184|reactome:R-MMU-176409|reactome:R-MMU-179409|refseq:XP_006506469.1|mint:MINT-8212310(identity) ensembl:ENSMUST00000027202(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008104"(protein localization)|go:"GO:0010789"(meiotic sister chromatid cohesion involved in meiosis I)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:2000711"(positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q7TSY8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000026039(gene)|refseq:NP_001171338.1|refseq:NP_950172.1|mint:MINT-8212306(identity) - - - figure legend:sf1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:T2SuApPGRno6LWCTPwVqAvQEVZQ10090 rogid:DJjoQ6spU+RxltEduZMJRaCQN6A10090 intact-crc:05528EB27378FC3E|rigid:VICRdXwCVh0C82hHe1Uj9HIxp1k false ha tag:?-?(MINT-8212311) flag tag:?-?(MINT-8212307) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977481|mint:MINT-8212589|imex:IM-16319-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212591(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8212593(identity) - - - comment:homomint|comment:mint|figure legend:sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:019F9749BEF20849|rigid:KJoPoLVu+sJuj9xfR6/gJSJAjGw false flag tag:?-?(MINT-8212599) myc tag:?-?(MINT-8212602) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:P62136 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977481|mint:MINT-8212589|imex:IM-16319-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212591(identity) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|mint:MINT-8212595(identity) - - - comment:homomint|comment:mint|figure legend:sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:019F9749BEF20849|rigid:KJoPoLVu+sJuj9xfR6/gJSJAjGw false flag tag:?-?(MINT-8212599) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q562F6 uniprotkb:P62136 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977517|mint:MINT-8212619|imex:IM-16319-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212621(identity) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|mint:MINT-8212629(identity) - - - comment:homomint|comment:mint|figure legend:sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:C39AC0604500351B|rigid:jUiC/XCa9GbzjbbTf9rb4/qQkjg false flag tag:?-?(MINT-8212622)|mutation disrupting interaction:58-58(MINT-8212633) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977536|mint:MINT-8295741|imex:IM-16319-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8295743(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8295747(identity) - - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:50470E6C0336AED0|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false flag tag:?-?(MINT-8295744) ha tag:?-?(MINT-8295750) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977563|mint:MINT-8210355|imex:IM-16319-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210357(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8210361(identity) - - - comment:homomint|comment:mint|figure legend:f1b f2d f2e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:FB7AB4BC34700C25|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false mutation disrupting interaction:153-153(MINT-8210453)|fusion protein:?-?(MINT-8210358)|binding-associated region:1-250(MINT-8210448) fusion protein:?-?(MINT-8210367) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0018"(two hybrid) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977636|mint:MINT-8210458|imex:IM-16319-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210462(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210460(identity) - comment:mint comment:mint comment:mint|figure legend:f2a sf1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:3619F367517581E2|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false mutation disrupting interaction:170-170(MINT-8212335)|fusion protein:?-?(MINT-8210467)|binding-associated region:101-200(MINT-8210469) fusion protein:?-?(MINT-8210472) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q562F6 uniprotkb:Q14738 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-396563|uniprotkb:O00494|uniprotkb:O00696|uniprotkb:Q15171|uniprotkb:Q5TC39|uniprotkb:B5BUA6|uniprotkb:A8K3I9|ensembl:ENSP00000417963 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:2a5d_human(display_long)|uniprotkb:PPP2R5D(gene name)|psi-mi:PPP2R5D(display_short)|uniprotkb:PP2A B subunit isoform B'-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-delta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977678|mint:MINT-8212557|imex:IM-16319-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212559(identity) refseq:NP_006236.1|refseq:NP_851307.1|refseq:NP_851308.1|ensembl:ENSG00000112640(gene)|ensembl:ENST00000485511(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q14738|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9634600|reactome:R-HSA-9648025|refseq:NP_001257405.1|dip:DIP-29961N|mint:MINT-8212567(identity) - - - comment:homomint|comment:mint|figure legend:f2e f1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:tQnhuUL/6Iuhcyu/B41Me1LWpr89606 intact-crc:80CF12DA1F3D5D61|rigid:NGB1XCs3+o03JQLmj9dgD0VUVAw false fusion protein:?-?(MINT-8212564)|binding-associated region:1-250(MINT-8212562) fusion protein:?-?(MINT-8212568) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z1B5 uniprotkb:Q7TSY8 intact:EBI-2552918|ensembl:ENSMUSP00000098897|ensembl:ENSMUSP00000112304|uniprotkb:Q9JI53 intact:EBI-2552468|ensembl:ENSMUSP00000027202|uniprotkb:Q8C9C4|uniprotkb:Q811I4|uniprotkb:Q9CS55|uniprotkb:Q8CGJ4 psi-mi:md2l1_mouse(display_long)|uniprotkb:Mad2l1(gene name)|psi-mi:Mad2l1(display_short)|uniprotkb:Mad2a(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:sgo2_mouse(display_long)|uniprotkb:Sgo2(gene name)|psi-mi:Sgo2(display_short)|uniprotkb:Sgol2(gene name synonym)|uniprotkb:Sgol2a(gene name synonym)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977660|mint:MINT-8212317|imex:IM-16319-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062372.2|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-2467813|ensembl:ENSMUSG00000029910(gene)|ensembl:ENSMUST00000101343(transcript)|ensembl:ENSMUST00000116605(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q9Z1B5|reactome:R-MMU-141405|reactome:R-MMU-141430|reactome:R-MMU-141444|reactome:R-MMU-174184|reactome:R-MMU-176409|reactome:R-MMU-179409|refseq:XP_006506469.1|mint:MINT-8212323(identity) ensembl:ENSMUST00000027202(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008104"(protein localization)|go:"GO:0010789"(meiotic sister chromatid cohesion involved in meiosis I)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:2000711"(positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q7TSY8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000026039(gene)|refseq:NP_001171338.1|refseq:NP_950172.1|mint:MINT-8212319(identity) - - - figure legend:sf1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/10/03 2014/10/16 rogid:T2SuApPGRno6LWCTPwVqAvQEVZQ10090 rogid:DJjoQ6spU+RxltEduZMJRaCQN6A10090 intact-crc:7030A12D44D9DC83|rigid:VICRdXwCVh0C82hHe1Uj9HIxp1k false fusion protein:?-?(MINT-8212324) fusion protein:?-?(MINT-8212320) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7 uniprotkb:Q14738 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 intact:EBI-396563|uniprotkb:O00494|uniprotkb:O00696|uniprotkb:Q15171|uniprotkb:Q5TC39|uniprotkb:B5BUA6|uniprotkb:A8K3I9|ensembl:ENSP00000417963 psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:2a5d_human(display_long)|uniprotkb:PPP2R5D(gene name)|psi-mi:PPP2R5D(display_short)|uniprotkb:PP2A B subunit isoform B'-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-delta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977699|mint:MINT-8295766|imex:IM-16319-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N|mint:MINT-8295768(identity) refseq:NP_006236.1|refseq:NP_851307.1|refseq:NP_851308.1|ensembl:ENSG00000112640(gene)|ensembl:ENST00000485511(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q14738|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9634600|reactome:R-HSA-9648025|refseq:NP_001257405.1|dip:DIP-29961N|mint:MINT-8295774(identity) - - - figure legend:f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/10/03 2014/10/16 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rogid:tQnhuUL/6Iuhcyu/B41Me1LWpr89606 intact-crc:AF2CB9F9A25A7952|rigid:zniV9PvcfNAZVs3MY9aKSzXabIs false fusion protein:?-?(MINT-8295769) fusion protein:?-?(MINT-8295775) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977756|mint:MINT-8210383|imex:IM-16319-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210385(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8210389(identity) go:"GO:0000785"(chromatin) - - figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:F6CFD7E497E9B4B3|rigid:KJoPoLVu+sJuj9xfR6/gJSJAjGw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q562F6 uniprotkb:P62136 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6977756|mint:MINT-8210383|imex:IM-16319-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8210385(identity) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|mint:MINT-8210405(identity) go:"GO:0000785"(chromatin) - - figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:F6CFD7E497E9B4B3|rigid:KJoPoLVu+sJuj9xfR6/gJSJAjGw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977781|mint:MINT-8210438|imex:IM-16319-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210441(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210440(identity) - comment:mint comment:mint figure legend:f1e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:CAA226CE0A5E9100|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0047"(far western blotting) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977801|mint:MINT-8210475|imex:IM-16319-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210481(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210477(identity) - comment:mint comment:mint comment:mint|figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:90A10A62E2F23EE8|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false binding-associated region:160-180(MINT-8210482)|mutation decreasing interaction:166-166(MINT-8210772) his tag:?-?(MINT-8210478) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0047"(far western blotting) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977822|mint:MINT-8210776|imex:IM-16319-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210782(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210778(identity) - comment:mint comment:mint comment:mint|figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:C8F748E336069669|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false binding-associated region:160-180(MINT-8210785)|mutation decreasing interaction:172-172(MINT-8210783) his tag:?-?(MINT-8210779) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0047"(far western blotting) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977879|mint:MINT-8210806|imex:IM-16319-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210808(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210812(identity) - comment:mint comment:mint comment:mint|figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:52BDF97574AA8B86|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false his tag:?-?(MINT-8210809) binding-associated region:160-180(MINT-8210815)|mutation disrupting interaction:171-171(MINT-8210813) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0047"(far western blotting) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977843|mint:MINT-8210791|imex:IM-16319-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210797(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210793(identity) - comment:mint comment:mint comment:mint|figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:0A37E362919D6402|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false binding-associated region:160-180(MINT-8210798)|mutation disrupting interaction:169-169(MINT-8210800) his tag:?-?(MINT-8210794) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0047"(far western blotting) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977900|mint:MINT-8210821|imex:IM-16319-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210827(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210823(identity) - comment:mint comment:mint comment:mint|figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:E929C8B1B094F1B9|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false binding-associated region:160-180(MINT-8210828)|mutation disrupting interaction:170-170(MINT-8210830) his tag:?-?(MINT-8210824) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6977930|mint:MINT-8210840|imex:IM-16319-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8210842(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8210844(identity) - comment:mint comment:mint comment:mint|figure legend:f2h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:FC4567CBA35F6BDF|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false ha tag:?-?(MINT-8210848) mutation disrupting interaction:170-170(MINT-8210853)|flag tag:?-?(MINT-8210851) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6GPD1 uniprotkb:Q91912 intact:EBI-1001368 intact:EBI-6977603|intact:MINT-8210424 psi-mi:q6gpd1_xenla(display_long)|uniprotkb:mad1l1.L(gene name)|psi-mi:mad1l1.L(display_short)|uniprotkb:Xmad1(gene name synonym)|uniprotkb:mad1-A(gene name synonym)|uniprotkb:mad1l1(gene name synonym)|uniprotkb:XELAEV_18045235mg(orf name) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977974|mint:MINT-8211729|imex:IM-16319-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008672(Mitotic checkpoint)|refseq:NP_001080972.1|go:"GO:0005634"(nucleus)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|refseq:XP_018089610.1|mint:MINT-8211733(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211731(identity) - - comment:mint figure legend:f3a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:mLB9zxj5o2WZ2zj7JQVbQiJJEP48355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:CB93C4BD2BE87CA4|rigid:bp4MthQZenyYAo8MSDb5HWKvHwc false binding-associated region:541-549(MINT-8211734) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977960|mint:MINT-8211036|imex:IM-16319-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211038(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8211042(identity) - comment:mint comment:mint figure legend:f3b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:3522A29CAE01E7AE|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false - binding-associated region:166-174(MINT-8211338) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6977988|mint:MINT-8211891|imex:IM-16319-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211893(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8211895(identity) - comment:mint comment:mint comment:mint|figure legend:sf2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:218A9B6AB75FDA91|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false - binding-associated region:155-179(MINT-8211896) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978027|mint:MINT-8211342|imex:IM-16319-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211344(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8211346(identity) - comment:mint comment:mint comment:mint|figure legend:f3c sf2g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:00BD72665FC44BEC|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false his tag:?-?(MINT-8211360) binding-associated region:108-207(MINT-8211347)|maltose binding protein tag:?-?(MINT-8211364) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q91912 uniprotkb:Q6GPD1 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-1001368 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:q6gpd1_xenla(display_long)|uniprotkb:mad1l1.L(gene name)|psi-mi:mad1l1.L(display_short)|uniprotkb:Xmad1(gene name synonym)|uniprotkb:mad1-A(gene name synonym)|uniprotkb:mad1l1(gene name synonym)|uniprotkb:XELAEV_18045235mg(orf name) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6978047|mint:MINT-8211367|imex:IM-16319-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211369(identity) interpro:IPR008672(Mitotic checkpoint)|refseq:NP_001080972.1|go:"GO:0005634"(nucleus)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|refseq:XP_018089610.1|mint:MINT-8211520(identity) - comment:mint - figure legend:f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:mLB9zxj5o2WZ2zj7JQVbQiJJEP48355 intact-crc:51AFBDF355F2D517|rigid:I01NGXPpfTakaGVXwvo1qI+1BvA false his tag:?-?(MINT-8211370) binding-associated region:485-586(MINT-8211532)|glutathione s tranferase tag:?-?(MINT-8211529) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6978047|mint:MINT-8211367|imex:IM-16319-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211369(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8211373(identity) - comment:mint comment:mint figure legend:f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:51AFBDF355F2D517|rigid:I01NGXPpfTakaGVXwvo1qI+1BvA false his tag:?-?(MINT-8211370) maltose binding protein tag:?-?(MINT-8211374)|binding-associated region:108-207(MINT-8211376) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6GPD1 uniprotkb:Q91912 intact:EBI-1001368 intact:EBI-6977603|intact:MINT-8210424 psi-mi:q6gpd1_xenla(display_long)|uniprotkb:mad1l1.L(gene name)|psi-mi:mad1l1.L(display_short)|uniprotkb:Xmad1(gene name synonym)|uniprotkb:mad1-A(gene name synonym)|uniprotkb:mad1l1(gene name synonym)|uniprotkb:XELAEV_18045235mg(orf name) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978076|mint:MINT-8211538|imex:IM-16319-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008672(Mitotic checkpoint)|refseq:NP_001080972.1|go:"GO:0005634"(nucleus)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|refseq:XP_018089610.1|mint:MINT-8211550(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211540(identity) - - comment:mint figure legend:f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:mLB9zxj5o2WZ2zj7JQVbQiJJEP48355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:6D36008AB195F4E8|rigid:bp4MthQZenyYAo8MSDb5HWKvHwc false glutathione s tranferase tag:?-?(MINT-8211553)|binding-associated region:485-586(MINT-8211551) his tag:?-?(MINT-8211541) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978111|mint:MINT-8211632|imex:IM-16319-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8211638(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8211634(identity) - comment:mint comment:mint|comment:"Stoichiometry: 2.0" figure legend:f4a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:0FEED4A135085B23|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false maltose binding protein tag:?-?(MINT-8211639)|binding-associated region:1-207(MINT-8211641) mutation disrupting interaction:458-467(MINT-8211707)|his tag:?-?(MINT-8211635) - 2 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q4KLP8 uniprotkb:Q91912 intact:EBI-6977619|intact:MINT-8210409 intact:EBI-6977603|intact:MINT-8210424 psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978136|mint:MINT-8212375|imex:IM-16319-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8212381(identity) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8212377(identity) - comment:mint comment:mint comment:mint|figure legend:sf2d sf2e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 intact-crc:1BCF37944751FAF8|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false calmodulin binding peptide plus protein a tag:?-?(MINT-8212382)|binding-associated region:108-207(MINT-8212384) his tag:?-?(MINT-8212378)|mutation disrupting interaction:458-467(MINT-8212403) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6978175|mint:MINT-8212500|imex:IM-16319-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8212502(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8212508(identity) - comment:mint comment:mint comment:mint|figure legend:sf2g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:5BE545736B655EF5|rigid:zmX/QMJ7XJyL8VpwliFmsN0QNUo false his tag:?-?(MINT-8212503) calmodulin binding peptide plus protein a tag:?-?(MINT-8212511)|binding-associated region:108-207(MINT-8212509) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q91912 uniprotkb:Q6DFD4 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-2943560 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:q6dfd4_xenla(display_long)|uniprotkb:cdc20.L(gene name)|psi-mi:cdc20.L(display_short)|uniprotkb:LOC398044(gene name synonym)|uniprotkb:cdc20(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6978175|mint:MINT-8212500|imex:IM-16319-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8212502(identity) go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001081776.1|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:MINT-8212517(identity) - comment:mint - comment:mint|figure legend:sf2g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:kWfjPAA7emJYiGomxf7HMBqFA+s8355 intact-crc:5BE545736B655EF5|rigid:zmX/QMJ7XJyL8VpwliFmsN0QNUo false his tag:?-?(MINT-8212503) glutathione s tranferase tag:?-?(MINT-8212518)|binding-associated region:114-146(MINT-8212521) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q91912 uniprotkb:Q6DFD4 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-2943560 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:q6dfd4_xenla(display_long)|uniprotkb:cdc20.L(gene name)|psi-mi:cdc20.L(display_short)|uniprotkb:LOC398044(gene name synonym)|uniprotkb:cdc20(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978204|mint:MINT-8212524|imex:IM-16319-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8212526(identity) go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001081776.1|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:MINT-8212538(identity) - comment:mint - comment:mint|figure legend:sf2g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:kWfjPAA7emJYiGomxf7HMBqFA+s8355 intact-crc:EE015B3BF8FCB60F|rigid:pbkSUL/GRn3F1qG7X0YP5UplwnQ false his tag:?-?(MINT-8212529) glutathione s tranferase tag:?-?(MINT-8212541)|binding-associated region:114-146(MINT-8212539) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q13257 uniprotkb:Q4KLP8 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 intact:EBI-6977619|intact:MINT-8210409 psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6978224|mint:MINT-8212685|imex:IM-16319-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8212687(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8212691(identity) - - comment:mint figure legend:sf2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:AA2AACE7CE310146|rigid:JL4/4CPeCwbnhpAEgGRf8vc6bSc false mutation disrupting interaction:196-205(MINT-8212724)|his tag:?-?(MINT-8212688) binding-associated region:1-207(MINT-8212694)|maltose binding protein tag:?-?(MINT-8212692) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q13257 uniprotkb:Q14738 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 intact:EBI-396563|uniprotkb:O00494|uniprotkb:O00696|uniprotkb:Q15171|uniprotkb:Q5TC39|uniprotkb:B5BUA6|uniprotkb:A8K3I9|ensembl:ENSP00000417963 psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:2a5d_human(display_long)|uniprotkb:PPP2R5D(gene name)|psi-mi:PPP2R5D(display_short)|uniprotkb:PP2A B subunit isoform B'-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-delta(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-delta(gene name synonym) psi-mi:"MI:0096"(pull down) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6978224|mint:MINT-8212685|imex:IM-16319-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8212687(identity) refseq:NP_006236.1|refseq:NP_851307.1|refseq:NP_851308.1|ensembl:ENSG00000112640(gene)|ensembl:ENST00000485511(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q14738|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9634600|reactome:R-HSA-9648025|refseq:NP_001257405.1|dip:DIP-29961N|mint:MINT-8212699(identity) - - - figure legend:sf2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 rogid:tQnhuUL/6Iuhcyu/B41Me1LWpr89606 intact-crc:AA2AACE7CE310146|rigid:JL4/4CPeCwbnhpAEgGRf8vc6bSc false mutation disrupting interaction:196-205(MINT-8212724)|his tag:?-?(MINT-8212688) myc tag:?-?(MINT-8212717) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978263|mint:MINT-8211871|imex:IM-16319-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8211873(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8211877(identity) - - - figure legend:sf2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.85x10^-7(molar) 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:2DA48E8625D7375F|rigid:pH7hrfIEw89v0bIe/goayKkPGYk false binding-associated region:143-158(MINT-8211884) - - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q562F6 uniprotkb:Q99661 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-1642317|uniprotkb:Q96C18|uniprotkb:Q96HB8|uniprotkb:Q9BWV8|uniprotkb:Q5JR88|uniprotkb:B3ITR9|uniprotkb:Q6ICU1|ensembl:ENSP00000361298 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:kif2c_human(display_long)|uniprotkb:KNSL6(gene name synonym)|uniprotkb:KIF2C(gene name)|psi-mi:KIF2C(display_short)|uniprotkb:Mitotic centromere-associated kinesin(gene name synonym)|uniprotkb:Kinesin-like protein 6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6978350|mint:MINT-8212643|imex:IM-16319-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212645(identity) refseq:NP_006836.2|refseq:NP_001284584.1|refseq:NP_001284585.1|refseq:NP_001284586.1|ensembl:ENSG00000142945(gene)|ensembl:ENST00000372224(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q99661|rcsb pdb:2HEH|rcsb pdb:4UBF|rcsb pdb:4Y05|rcsb pdb:5MIO|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189|mint:MINT-8212655(identity) - - - comment:homomint|comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:XKQr6i+9Xtdfir6V1C8PByAIg1c9606 intact-crc:20B48EADBEC4653B|rigid:Ow3P9SNQsGqzyXkq2AoTFlRtUwQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q562F6 uniprotkb:P62136 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6978350|mint:MINT-8212643|imex:IM-16319-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212645(identity) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|mint:MINT-8212649(identity) - - - comment:homomint|comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:20B48EADBEC4653B|rigid:Ow3P9SNQsGqzyXkq2AoTFlRtUwQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q562F6 uniprotkb:Q13257 intact:EBI-989213|ensembl:ENSP00000350447|uniprotkb:Q53RR9|uniprotkb:Q53T20|uniprotkb:Q86XY4|uniprotkb:Q8IWK2|uniprotkb:Q8IZK1|uniprotkb:Q8N1Q5|uniprotkb:Q96LQ3|intact:EBI-2559582 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:sgo2_human(display_long)|uniprotkb:SGO2(gene name)|psi-mi:SGO2(display_short)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym)|uniprotkb:Tripin(gene name synonym)|uniprotkb:SGOL2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-6978350|mint:MINT-8212643|imex:IM-16319-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163535(gene)|ensembl:ENST00000357799(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q562F6|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:XP_011509036.1|refseq:NP_001153518.1|refseq:NP_689737.4|refseq:XP_005246402.1|dip:DIP-36615N|mint:MINT-8212645(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|mint:MINT-8212647(identity) - - - comment:homomint|comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/10/03 2014/10/16 rogid:lj8jTnNLhIEEqgqjvOrIJIS57yc9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:20B48EADBEC4653B|rigid:Ow3P9SNQsGqzyXkq2AoTFlRtUwQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91912 uniprotkb:Q4KLP8 intact:EBI-6977603|intact:MINT-8210424 intact:EBI-6977619|intact:MINT-8210409 psi-mi:q91912_xenla(display_long)|uniprotkb:Mad2(gene name)|psi-mi:Mad2(display_short)|uniprotkb:SMAD family member(gene name synonym) psi-mi:sgo1_xenla(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:sgo(gene name synonym)|uniprotkb:sgol1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Orth et al. (2011) pubmed:21666598|imex:IM-16319|mint:MINT-8210319|doi:10.1038/emboj.2011.187 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6978378|mint:MINT-8295895|imex:IM-16319-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR036578|mint:MINT-8295897(identity) refseq:XP_018122216.1|refseq:XP_018122217.1|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005874"(microtubule)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR028321|interpro:IPR011516(Shugoshin, N-terminal)|refseq:NP_001090071.1|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR038889|mint:MINT-8295903(identity) - comment:mint comment:mint comment:mint|figure legend:sf2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/03 2014/10/16 rogid:C2iCdflMsIFUuuwJDFv2ch83Coo8355 rogid:d2MQL7VApmT6/Ac9yro3ZwvoY+s8355 intact-crc:A81DFB89A0211699|rigid:bVMLMCZJ4LlUk3gO0gQ1ufQJ+b4 false his tag:?-?(MINT-8295900)|mutation disrupting interaction:458-467(MINT-8295898) binding-associated region:108-207(MINT-8295906)|calmodulin binding peptide plus protein a tag:?-?(MINT-8295904) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)