#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P43146 uniprotkb:Q9HD67 intact:EBI-1222919|ensembl:ENSP00000389140 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970034|mint:MINT-8199598|imex:IM-15865-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199606(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199600(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F3d sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:9739AD2CB1AF6A03|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false glutathione s tranferase tag:?-?(MINT-8199609)|binding-associated region:1390-1447(MINT-8199607) binding-associated region:1486-2058(IPR000299)|mutation disrupting interaction:1439-1439(MINT-8199601) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9HD67 uniprotkb:P43146 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 intact:EBI-1222919|ensembl:ENSP00000389140 psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970004|mint:MINT-8199557|imex:IM-15865-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199559(identity) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199567(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F3d sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 intact-crc:55A083E7A7159871|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false binding-associated region:1486-2058(IPR000299)|mutation disrupting interaction:1432-1432(MINT-8199560) glutathione s tranferase tag:?-?(MINT-8199591)|binding-associated region:1390-1447(MINT-8199593) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q71U36 uniprotkb:Q9HD67 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970144|mint:MINT-8199662|imex:IM-15865-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|mint:MINT-8199670(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199664(identity) - - - figure legend:F5b|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:4E85535129D30B14|rigid:pgkrynIoxwqVrztcnNt69nXhsgA false glutathione s tranferase tag:?-?(MINT-8199710)|binding-associated region:399-451(MINT-8199673) binding-associated region:1486-2058(IPR000299) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9HD67 uniprotkb:P43146 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 intact:EBI-1222919|ensembl:ENSP00000389140 psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970114|mint:MINT-8199637|imex:IM-15865-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199639(identity) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199647(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F3d sf1b f5c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 intact-crc:458C6DBE6C03C3A4|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false binding-associated region:1486-2058(IPR000299)|mutation disrupting interaction:2002-2002(MINT-8199640) binding-associated region:1390-1447(MINT-8199648)|glutathione s tranferase tag:?-?(MINT-8199650) - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43146 uniprotkb:Q9HD67 intact:EBI-1222919|ensembl:ENSP00000389140 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970064|mint:MINT-8199615|imex:IM-15865-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199623(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199617(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F3d sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:58B024D89417C3A5|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false binding-associated region:1390-1447(MINT-8199626)|glutathione s tranferase tag:?-?(MINT-8199624) binding-associated region:1486-2058(IPR000299)|mutation disrupting interaction:1435-1435(MINT-8199620)|mutation disrupting interaction:1436-1436(MINT-8199631) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P18084 uniprotkb:Q9HD67 intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970202|mint:MINT-8199748|imex:IM-15865-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355|mint:MINT-8199758(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199750(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F5g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:AAB2DD01984ADE4B|rigid:JcftLxTPZMA6qviURY60F1dTVeY false glutathione s tranferase tag:?-?(MINT-8199761)|binding-associated region:743-799(MINT-8199759) binding-associated region:1486-2058(IPR000299) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9BVA1 uniprotkb:Q9HD67 intact:EBI-355665|uniprotkb:A8K068|ensembl:ENSP00000259818 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:tbb2b_human(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0096"(pull down) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970169|mint:MINT-8199713|imex:IM-15865-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_821080.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BVA1|rcsb pdb:6E7C|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|ensembl:ENST00000259818(transcript)|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-5663220|ensembl:ENSG00000137285(gene)|mint:MINT-8199719(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199715(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F5b f5c f5e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:sluQMryNuOvp6xlV558+agiRwvE9606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:B9026D6052F746E4|rigid:ieJzY9LYLSrC8NgPXK7BArzBBNQ false binding-associated region:390-445(MINT-8199722)|glutathione s tranferase tag:?-?(MINT-8199720) mutation disrupting interaction:1647-1647(MINT-8199741)|mutation disrupting interaction:1650-1650(MINT-8199744)|binding-associated region:1486-2058(IPR000299) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P43146 uniprotkb:Q9HD67 intact:EBI-1222919|ensembl:ENSP00000389140 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6970252|mint:MINT-8199139|imex:IM-15865-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199146(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199142(identity) - - - figure legend:F3c|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/07/18 2014/10/16 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:4E8E3AC72A7AAB9F|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false - binding-associated region:1954-2058(IPR000299)|myc tag:?-?(MINT-8199172) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HD67 uniprotkb:P43146 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 intact:EBI-1222919|ensembl:ENSP00000389140 psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970282|mint:MINT-8199123|imex:IM-15865-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199125(identity) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199129(identity) - - - figure legend:F1c|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:5.3x10^-7(molar) 2011/07/18 2014/10/16 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 intact-crc:00C291EE5FF82DBB|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false binding-associated region:1486-2058(IPR000299) binding-associated region:1390-1447(MINT-8199130) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HD67 uniprotkb:P43146 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 intact:EBI-1222919|ensembl:ENSP00000389140 psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6970314|mint:MINT-8199109|imex:IM-15865-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199111(identity) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199112(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F2a f2b f3a f4 f6a t1 sf4 sf6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 intact-crc:3609F6D34E3E7A90|rigid:s2ylJyhsCnecOpO/WYK0civCDXI false binding-associated region:1501-2046(IPR000299) binding-associated region:1414-1445(MINT-8199120) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18084 uniprotkb:P43146 intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181 intact:EBI-1222919|ensembl:ENSP00000389140 psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short) psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym) psi-mi:"MI:0405"(competition binding) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6970361|mint:MINT-8199775|imex:IM-15865-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355|mint:MINT-8199783(identity) refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542|mint:MINT-8199819(identity) - - comment:"MI:0941" comment:homomint|comment:domino|comment:mint|figure legend:F5g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606 rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606 intact-crc:0D9A51F6B92EAC25|rigid:tAIWl0LiprgYkr6P31i+/OJ8dGc false binding-associated region:743-799(MINT-8199786)|glutathione s tranferase tag:?-?(MINT-8199784) binding-associated region:1390-1447(MINT-8199821) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18084 uniprotkb:Q9HD67 intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0405"(competition binding) Hirano et al. (2011) pubmed:21642953|imex:IM-15865|mint:MINT-8199092|doi:10.1038/emboj.2011.177 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6970361|mint:MINT-8199775|imex:IM-15865-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355|mint:MINT-8199783(identity) ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1|mint:MINT-8199777(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:F5g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/18 2014/10/16 rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:0D9A51F6B92EAC25|rigid:tAIWl0LiprgYkr6P31i+/OJ8dGc false binding-associated region:743-799(MINT-8199786)|glutathione s tranferase tag:?-?(MINT-8199784) binding-associated region:1486-2058(IPR000299) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)