#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7Z6J0	uniprotkb:O43255	intact:EBI-311339|intact:EBI-1374106|uniprotkb:Q05BT2|uniprotkb:Q8IW46|uniprotkb:Q9HAM2|uniprotkb:Q9P234|ensembl:ENSP00000284637	intact:EBI-948141|uniprotkb:O43270|ensembl:ENSP00000322457	psi-mi:sh3r1_human(display_long)|uniprotkb:SH3RF1(gene name)|psi-mi:SH3RF1(display_short)|uniprotkb:POSH1(gene name synonym)|uniprotkb:KIAA1494(gene name synonym)|uniprotkb:POSH(gene name synonym)|uniprotkb:RNF142(gene name synonym)|uniprotkb:SH3MD2(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:RING finger protein 142(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:siah2_human(display_long)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:SIAH2(gene name)|psi-mi:SIAH2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Christian et al. (2011)	pubmed:21586138|imex:IM-16914	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371961|imex:IM-16914-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|mint:Q7Z6J0|reactome:R-HSA-9013424|reactome:R-HSA-983168|ensembl:ENSG00000154447(gene)|ensembl:ENST00000284637(transcript)|refseq:NP_065921.2|dip:DIP-31636N	refseq:NP_005058.3|dip:DIP-41874N|ensembl:ENSG00000181788(gene)|ensembl:ENST00000312960(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:5H9M|reactome:R-HSA-373752|reactome:R-HSA-5689880|reactome:R-HSA-977225|reactome:R-HSA-983168	-	-	-	figure legend:5a, 5c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/08/22	2014/10/16	rogid:xt8KC10AwFS6xTZVVApagbbyiJ49606	rogid:1AUfjiUQFAEsOkxiSwdWZX4aPbY9606	intact-crc:34E2FD05D41C97D7|rigid:1XFNbbctV1R9MVctxCpQlSTX5eA	false	mutation disrupting interaction:605-605,607-607|sufficient binding region:594-612|necessary binding region:506-829	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43255	uniprotkb:Q7Z6J0	intact:EBI-948141|uniprotkb:O43270|ensembl:ENSP00000322457	intact:EBI-311339|intact:EBI-1374106|uniprotkb:Q05BT2|uniprotkb:Q8IW46|uniprotkb:Q9HAM2|uniprotkb:Q9P234|ensembl:ENSP00000284637	psi-mi:siah2_human(display_long)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:SIAH2(gene name)|psi-mi:SIAH2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:sh3r1_human(display_long)|uniprotkb:SH3RF1(gene name)|psi-mi:SH3RF1(display_short)|uniprotkb:POSH1(gene name synonym)|uniprotkb:KIAA1494(gene name synonym)|uniprotkb:POSH(gene name synonym)|uniprotkb:RNF142(gene name synonym)|uniprotkb:SH3MD2(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:RING finger protein 142(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Christian et al. (2011)	pubmed:21586138|imex:IM-16914	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4371981|imex:IM-16914-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005058.3|dip:DIP-41874N|ensembl:ENSG00000181788(gene)|ensembl:ENST00000312960(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:5H9M|reactome:R-HSA-373752|reactome:R-HSA-5689880|reactome:R-HSA-977225|reactome:R-HSA-983168	go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|mint:Q7Z6J0|reactome:R-HSA-9013424|reactome:R-HSA-983168|ensembl:ENSG00000154447(gene)|ensembl:ENST00000284637(transcript)|refseq:NP_065921.2|dip:DIP-31636N	-	-	-	figure legend:5b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ppc-1)|taxid:9606(human prostatic carcinoma cell line PPC-1)	-	2011/08/22	2014/10/16	rogid:1AUfjiUQFAEsOkxiSwdWZX4aPbY9606	rogid:xt8KC10AwFS6xTZVVApagbbyiJ49606	intact-crc:C87AB41C9BE4F050|rigid:1XFNbbctV1R9MVctxCpQlSTX5eA	false	ha tag:c-c|mutation:98-98,101-101	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)