#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946009|mint:MINT-8198843|imex:IM-16338-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199917(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8198845(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-mav203)|taxid:4932(Saccharomyces cerevisiae)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:8F4D3EADAAB4D750|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	binding-associated region:1-300(MINT-8199928)|fusion protein:?-?(MINT-8199925)	fusion protein:?-?(MINT-8199919)|binding-associated region:239-731(MINT-8199922)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946042|mint:MINT-8199931|imex:IM-16338-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199939(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8199933(identity)	imex:IM-16338-2(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:f1b|causality statement:Q9H469 is required for ubiquitination of Q9HCE7|causality statement:Q9H469 increases degradation at protein level of Q9HCE7|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:22337499E9ECC00D|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	glutathione s tranferase tag:?-?(MINT-8199942)	his tag:?-?(MINT-8199936)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9HAU4	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946076|mint:MINT-8298439|imex:IM-16338-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298446(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-8298442(identity)	imex:IM-16338-2(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:sf6a|causality statement:Q9H469 is required for ubiquitination of Q9HAU4|causality statement:Q9H469 increases degradation at protein level of Q9HAU4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:02913908F7C8AD60|rigid:DNc8Ya8l5+UAFvZzCkZto0KRnzc	false	glutathione s tranferase tag:?-?(MINT-8298447)	his tag:?-?(MINT-8298443)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946270|mint:MINT-8199952|imex:IM-16338-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199958(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8199954(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:F421AB0A7705BE0E|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H469	uniprotkb:Q9HAU4	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946516|mint:MINT-8200043|imex:IM-16338-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8200047(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-8200045(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf6b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:71F32908B50FA581|rigid:DNc8Ya8l5+UAFvZzCkZto0KRnzc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H469	uniprotkb:Q13616	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946629|mint:MINT-8198846|imex:IM-16338-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199968(identity)	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N|mint:MINT-8198848(identity)	imex:IM-16338-5(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:f2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:550BBCF3181663D2|rigid:w3be1fhOIoFqQfx3MiQfLxAZkS8	false	flag tag:?-?(MINT-8199971)|necessary binding region:22-64(IPR001810)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H469	uniprotkb:P62877	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946629|mint:MINT-8198846|imex:IM-16338-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199968(identity)	refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|mint:MINT-8198850(identity)	imex:IM-16338-5(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:f2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606	intact-crc:550BBCF3181663D2|rigid:w3be1fhOIoFqQfx3MiQfLxAZkS8	false	flag tag:?-?(MINT-8199971)|necessary binding region:22-64(IPR001810)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H469	uniprotkb:P63208	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946629|mint:MINT-8198846|imex:IM-16338-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8199968(identity)	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N|mint:MINT-8198849(identity)	imex:IM-16338-5(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:f2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	intact-crc:550BBCF3181663D2|rigid:w3be1fhOIoFqQfx3MiQfLxAZkS8	false	flag tag:?-?(MINT-8199971)|necessary binding region:22-64(IPR001810)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H469	uniprotkb:Q9HAU4	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946654|mint:MINT-8297030|imex:IM-16338-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8297039(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-8297033(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:5B77054C544323A3|rigid:DNc8Ya8l5+UAFvZzCkZto0KRnzc	false	myc tag:?-?(MINT-8297042)	flag tag:?-?(MINT-8297570)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946687|mint:MINT-8298316|imex:IM-16338-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298319(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8298323(identity)	imex:IM-16338-5(imex secondary)	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f6a f1d f1f|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:8D072A3B5EC3834F|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	binding-associated region:113-269(MINT-8298331)|myc tag:?-?(MINT-8298320)	flag tag:?-?(MINT-8298324)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:P46934	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946726|mint:MINT-8298340|imex:IM-16338-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298343(identity)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N|mint:MINT-8298347(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	intact-crc:1E2908B0756E5FFD|rigid:QGlJUtFhU9a6BU+tG3CUd2DVisw	false	myc tag:?-?(MINT-8298344)	flag tag:?-?(MINT-8298348)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q96PU5	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946744|mint:MINT-8298353|imex:IM-16338-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298356(identity)	refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N|mint:MINT-8298360(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606	intact-crc:626AF0A41C6AE38B|rigid:f/WuZ92ZRRWx/GnccKcxI7G5Ff8	false	myc tag:?-?(MINT-8298357)	flag tag:?-?(MINT-8298361)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9P2P5	uniprotkb:Q9H469	intact:EBI-6946802|intact:EBI-28984830|ensembl:ENSP00000260983|ensembl:ENSP00000494649|ensembl:ENSP00000495418|uniprotkb:Q9NPS9|uniprotkb:Q68DF8|uniprotkb:B8ZZB4|uniprotkb:Q17RT5|intact:MINT-2820726	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	psi-mi:hecw2_human(display_long)|uniprotkb:HECW2(gene name)|psi-mi:HECW2(display_short)|uniprotkb:KIAA1301(gene name synonym)|uniprotkb:NEDL2(gene name synonym)|uniprotkb:HECT, C2 and WW domain-containing protein 2(gene name synonym)|uniprotkb:NEDD4-like E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECW2(gene name synonym)	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946796|mint:MINT-8298383|imex:IM-16338-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000260983|ensembl:ENSP00000494649|ensembl:ENSP00000495418|ensembl:ENST00000647236|ensembl:ENSP00000494800|ensembl:ENSG00000138411(gene)|ensembl:ENST00000260983(transcript)|ensembl:ENST00000644256(transcript)|ensembl:ENST00000644978(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072686"(mitotic spindle)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR032348|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|interpro:IPR037795|interpro:IPR040524|rcsb pdb:2LFE|reactome:R-HSA-983168|refseq:XP_016860052.1|refseq:NP_065811.1|mint:MINT-8298390(identity)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298386(identity)	imex:IM-16338-5(imex secondary)	comment:mint|comment:homomint|function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:H/E42z+iXwUKpRlxJPOQsWEwMp09606	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	intact-crc:A155D0284AD95243|rigid:Q6C1q39ApSK1TMZfQ1I+E/oImwo	false	flag tag:?-?(MINT-8298391)	myc tag:?-?(MINT-8298387)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q76N89	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-949582|ensembl:ENSP00000379228|uniprotkb:O15036|uniprotkb:Q9HCC7|uniprotkb:A7E2X0|uniprotkb:A8MYS3|uniprotkb:B4DH42|intact:EBI-11059486	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:hecw1_human(display_long)|uniprotkb:HECT, C2 and WW domain-containing protein 1(gene name synonym)|uniprotkb:NEDD4-like E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECW1(gene name)|psi-mi:HECW1(display_short)|uniprotkb:KIAA0322(gene name synonym)|uniprotkb:NEDL1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECW1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946778|mint:MINT-8298370|imex:IM-16338-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298373(identity)	go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR032348|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|interpro:IPR037795|interpro:IPR040524|mint:Q76N89|rcsb pdb:3L4H|reactome:R-HSA-4641258|ensembl:ENSG00000002746(gene)|ensembl:ENST00000395891(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|refseq:NP_055867.3|refseq:NP_001273988.1|refseq:XP_016867375.1|refseq:XP_016867378.1|mint:MINT-8298377(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:iK0wuIJT5WCj76JVf435fZeARkc9606	intact-crc:1827BA62345A9E56|rigid:rxwx/kfw6+tjEXsRta+i972jE8g	false	myc tag:?-?(MINT-8298374)	flag tag:?-?(MINT-8298378)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9H0M0	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-742157|uniprotkb:O00307|uniprotkb:Q96BP4|ensembl:ENSP00000265428|ensembl:ENSP00000427793|uniprotkb:Q5YLC1	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:wwp1_human(display_long)|uniprotkb:WWP1(gene name)|psi-mi:WWP1(display_short)|uniprotkb:WW domain-containing protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 5(gene name synonym)|uniprotkb:TGIF-interacting ubiquitin ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase WWP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946915|mint:MINT-8298409|imex:IM-16338-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298412(identity)	refseq:NP_008944.1|interpro:IPR035892|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR035983|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR036020|mint:Q9H0M0|rcsb pdb:1ND7|rcsb pdb:2OP7|rcsb pdb:5HPS|rcsb pdb:5HPT|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|rcsb pdb:6J1X|rcsb pdb:6J1Y|reactome:R-HSA-1253288|reactome:R-HSA-2672351|reactome:R-HSA-8939902|reactome:R-HSA-983168|interpro:IPR024928|ensembl:ENSG00000123124(gene)|ensembl:ENST00000265428(transcript)|ensembl:ENST00000517970(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_005250817.1|mint:MINT-8298416(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:a+aRHHhwu3pCkmlkDNqcN1PJ7LI9606	intact-crc:29A5C1953B64BCD0|rigid:PGdCHxbjVkNT0f5p3pYjSDmXu5g	false	myc tag:?-?(MINT-8298413)	flag tag:?-?(MINT-8298417)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q96J02	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946897|mint:MINT-8298396|imex:IM-16338-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298399(identity)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168|mint:MINT-8298403(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	intact-crc:AEDDD4D6000A3BA5|rigid:if0tU51FY8kYddPwP4WUi+D2u0s	false	myc tag:?-?(MINT-8298400)	flag tag:?-?(MINT-8298404)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:O00308	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946949|mint:MINT-8298422|imex:IM-16338-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298425(identity)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507|mint:MINT-8298429(identity)	imex:IM-16338-5(imex secondary)	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	intact-crc:359F760AA8EBD3E7|rigid:HafkbPDweI/x/8bzRttXQ3PonCI	false	myc tag:?-?(MINT-8298426)	flag tag:?-?(MINT-8298430)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6946967|mint:MINT-8298472|imex:IM-16338-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298480(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8298476(identity)	imex:IM-16338-2(imex secondary)	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1g f1h f1i|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:E1D4AF5A4A2CF32C|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	flag tag:?-?(MINT-8298481)	binding-associated region:373-539(MINT-8298487)|myc tag:?-?(MINT-8298477)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H469	uniprotkb:Q9HCE7	intact:EBI-6144096|uniprotkb:B1AKX9|uniprotkb:Q0D2Q3|uniprotkb:A1L4J8|uniprotkb:C9JWA4|uniprotkb:Q5JWA5|uniprotkb:Q49AL7|uniprotkb:B1AKY1|uniprotkb:B1AKY0|uniprotkb:B1AKX8|ensembl:ENSP00000358972	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:fxl15_human(display_long)|uniprotkb:F-box only protein 37(gene name synonym)|uniprotkb:FBXO37(gene name synonym)|uniprotkb:FBXL15(gene name)|psi-mi:FBXL15(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Cui et al. (2011)	pubmed:21572392|imex:IM-16338|mint:MINT-8198822|doi:10.1038/emboj.2011.155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6947063|mint:MINT-8298454|imex:IM-16338-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077302.3|refseq:XP_005270207.1|refseq:XP_005270208.1|refseq:XP_016872120.1|ensembl:ENSG00000107872(gene)|ensembl:ENST00000369956(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030282"(bone mineralization)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8298461(identity)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N|mint:MINT-8298457(identity)	go:"GO:0005737"(cytoplasm)|imex:IM-16338-2(imex secondary)	-	-	comment:homomint|comment:mint|figure legend:f1e sf1g|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2011/07/15	2014/10/16	rogid:mNR8gFDgo0wc6D/JUwPCw4sfy6I9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:BB01CB312D7CEFAA|rigid:5BxaDH+/rb0W+dWfm1q319jgn7g	false	myc tag:?-?(MINT-8298462)	flag tag:?-?(MINT-8298458)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)