#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53690	uniprotkb:Q61483	intact:EBI-6944251|ensembl:ENSMUSP00000087119|uniprotkb:O08645|intact:UNK-5380145|uniprotkb:Q8BTX2|uniprotkb:O35369	intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7	psi-mi:mmp14_mouse(display_long)|uniprotkb:Mmp14(gene name)|psi-mi:Mmp14(display_short)|uniprotkb:Mtmmp(gene name synonym)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MT-MMP(gene name synonym)	psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jin et al. (2011)	pubmed:21572390|imex:IM-15422|mint:MINT-8187247|doi:10.1038/emboj.2011.136	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6944245|mint:MINT-8187256|imex:IM-15422-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000957(gene)|ensembl:ENSMUST00000089688(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0060348"(bone development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|reactome:R-MMU-1442490|reactome:R-MMU-1474228|reactome:R-MMU-1592389|refseq:NP_032634.3|mint:MINT-8187258(identity)	go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N|mint:MINT-8187259(identity)	-	comment:mint|function:Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development	-	figure legend:f8a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmsc)|taxid:10090(Mus musculus)	-	2011/06/15	2014/10/16	rogid:JaYEtoEftemXCUD9uZd3gc4zfcM10090	rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090	intact-crc:E7495D81F92C698E|rigid:IDPE1ZwxRl4HE9Sj7Whv3MPkPHc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50281	uniprotkb:Q61483	intact:EBI-992788|uniprotkb:Q6GSF3|uniprotkb:Q92678|uniprotkb:A8K5L0|ensembl:ENSP00000308208	intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7	psi-mi:mmp14_human(display_long)|uniprotkb:Membrane-type matrix metalloproteinase 1(gene name synonym)|uniprotkb:Membrane-type-1 matrix metalloproteinase(gene name synonym)|uniprotkb:MMP-X1(gene name synonym)|uniprotkb:MMP14(gene name)|psi-mi:MMP14(display_short)	psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Jin et al. (2011)	pubmed:21572390|imex:IM-15422|mint:MINT-8187247|doi:10.1038/emboj.2011.136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6944370|mint:MINT-8187298|imex:IM-15422-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000311852(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010831"(positive regulation of myotube differentiation)|ensembl:ENSG00000157227(gene)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044354"(macropinosome)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048870"(cell motility)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060322"(head development)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990834"(response to odorant)|interpro:IPR000585(Hemopexin)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036366|interpro:IPR036375|mint:P50281|rcsb pdb:1BQQ|rcsb pdb:1BUV|rcsb pdb:2MQS|rcsb pdb:3MA2|rcsb pdb:3X23|rcsb pdb:4P3C|rcsb pdb:4P3D|rcsb pdb:4QXU|rcsb pdb:5H0U|rcsb pdb:6CLZ|rcsb pdb:6CM1|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|rcsb pdb:3C7X|refseq:NP_004986.1|dip:DIP-35111N|mint:MINT-8187300(identity)	go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N|mint:MINT-8187302(identity)	-	-	-	figure legend:sf6|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/15	2014/10/16	rogid:x2H2pYgnfBvYy7Stikq3uk+ihhw9606	rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090	intact-crc:FCB6C15A61ACB628|rigid:Wl2K3aE+PtZDyzYiKZtEYtNvHQI	false	binding-associated region:112-298(MINT-8187313)	binding-associated region:516-544(MINT-8187308)|uncategorized protein modification:527-527(MINT-8187310)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)