#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8I9J6	uniprotkb:Q95V55	intact:EBI-4288282	intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288316|imex:IM-15737-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227	intact-crc:548BB2436AF81EE0|rigid:tE4F79JDn1fYgCaOtBIeVjGVD8U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8I9J6	uniprotkb:Q95V55	intact:EBI-4288282	intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name)	psi-mi:"MI:0406"(deacetylase assay)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288327|imex:IM-15737-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638	go:"GO:0033558"(protein deacetylase activity)|go:"GO:0006476"(protein deacetylation)	-	-	figure legend:Fig. 6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227	intact-crc:ECC29E4C00FB819D|rigid:tE4F79JDn1fYgCaOtBIeVjGVD8U	false	-	sufficient binding region:95-198|glutathione s tranferase tag:?-?|monoacetylated residue:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8I9J6	uniprotkb:Q95RJ9	intact:EBI-4288282	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288423|imex:IM-15737-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	intact-crc:2A852BA5CA315D56|rigid:qb5P7uz4OnHKtsygxkBSOvYB68E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q8I9J6	uniprotkb:Q7KTS4	intact:EBI-4288282	intact:EBI-4288403|ensemblmetazoa:FBpp0078414	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:q7kts4_drome(display_long)|uniprotkb:DHDAC3(gene name synonym)|uniprotkb:DmHDAC3(gene name synonym)|uniprotkb:Dmel\CG2128(gene name synonym)|uniprotkb:HDAC(gene name synonym)|uniprotkb:Hdac 3(gene name synonym)|uniprotkb:dHDAC3(gene name synonym)|uniprotkb:dmHDA402(gene name synonym)|uniprotkb:hdac3(gene name synonym)|uniprotkb:Dmel_CG2128(orf name)|uniprotkb:Hdac3(gene name synonym)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:CG2128(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288423|imex:IM-15737-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	refseq:NP_651978.2|flybase:FBgn0025825|ensemblmetazoa:FBgn0025825(gene)|ensemblmetazoa:FBtr0078767(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|go:"GO:0019904"(protein domain specific binding)	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:bbD1rMYiTTEyd2plI1t9XfyjdlY7227	intact-crc:2A852BA5CA315D56|rigid:qb5P7uz4OnHKtsygxkBSOvYB68E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q8I9J6	uniprotkb:Q9VYK0	intact:EBI-4288282	intact:EBI-2508136|ensemblmetazoa:FBpp0305906|ensemblmetazoa:FBpp0305907|ensemblmetazoa:FBpp0305908	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:q9vyk0_drome(display_long)|uniprotkb:Smr(gene name)|psi-mi:Smr(display_short)|uniprotkb:CG12719(gene name synonym)|uniprotkb:CG4013(orf name)|uniprotkb:Dmel\CG4013(gene name synonym)|uniprotkb:E52(gene name synonym)|uniprotkb:SMR(gene name synonym)|uniprotkb:SMRTER(gene name synonym)|uniprotkb:anon-WO0153538.73(gene name synonym)|uniprotkb:"l(1)G0060"(gene name synonym)|uniprotkb:"l(1)G0361"(gene name synonym)|uniprotkb:lincRNA.983(gene name synonym)|uniprotkb:smr(gene name synonym)|uniprotkb:Dmel_CG4013(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288423|imex:IM-15737-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	ensemblmetazoa:FBgn0265523(gene)|ensemblmetazoa:FBtr0333765(transcript)|ensemblmetazoa:FBtr0333766(transcript)|go:"GO:0017053"(transcription repressor complex)|ensemblmetazoa:FBtr0333767(transcript)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016922"(nuclear receptor binding)|refseq:NP_536797.3|refseq:NP_727634.2|refseq:NP_727635.2|flybase:FBgn0265523	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:pR3pQt6Bo8AS/uv7VTo6u6yinYo7227	intact-crc:2A852BA5CA315D56|rigid:qb5P7uz4OnHKtsygxkBSOvYB68E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q4QQA7	-	intact:EBI-107683|ensemblmetazoa:FBpp0292993	-	psi-mi:q4qqa7_drome(display_long)|uniprotkb:Sik3(gene name)|psi-mi:Sik3(display_short)|uniprotkb:CG15072(gene name synonym)|uniprotkb:CG18604(gene name synonym)|uniprotkb:Dmel\CG42856(gene name synonym)|uniprotkb:EMK(gene name synonym)|uniprotkb:KIAA0999(gene name synonym)|uniprotkb:SIK(gene name synonym)|uniprotkb:SIK3(gene name synonym)|uniprotkb:CG42856(orf name)|uniprotkb:Dmel_CG42856(orf name)	-	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288258|imex:IM-15737-6	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_611359.1|flybase:FBgn0262103|ensemblmetazoa:FBgn0262103(gene)|ensemblmetazoa:FBtr0304024(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/20	2014/10/16	rogid:WTqlQVhnE96deUDryIIjWQPfAHc7227	-	intact-crc:5EFB4325682A92B4	false	ha tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q8INB9	uniprotkb:Q4QQA7	intact:EBI-162210|uniprotkb:Q0KI65|uniprotkb:Q24293|uniprotkb:Q24469|uniprotkb:Q24470|uniprotkb:Q7JN11|uniprotkb:Q8T9A5|uniprotkb:Q9VEY7|ensemblmetazoa:FBpp0082682	intact:EBI-107683|ensemblmetazoa:FBpp0292993	psi-mi:akt1_drome(display_long)|uniprotkb:Akt1(gene name)|psi-mi:Akt1(display_short)|uniprotkb:CG4006(orf name)|uniprotkb:Akt(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)	psi-mi:q4qqa7_drome(display_long)|uniprotkb:Sik3(gene name)|psi-mi:Sik3(display_short)|uniprotkb:CG15072(gene name synonym)|uniprotkb:CG18604(gene name synonym)|uniprotkb:Dmel\CG42856(gene name synonym)|uniprotkb:EMK(gene name synonym)|uniprotkb:KIAA0999(gene name synonym)|uniprotkb:SIK(gene name synonym)|uniprotkb:SIK3(gene name synonym)|uniprotkb:CG42856(orf name)|uniprotkb:Dmel_CG42856(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288266|imex:IM-15737-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_732113.3|refseq:NP_732114.1|refseq:NP_732115.1|flybase:FBgn0010379|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|reactome:R-DME-110478|reactome:R-DME-110523|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-1474151|reactome:R-DME-165158|reactome:R-DME-165159|reactome:R-DME-165181|reactome:R-DME-198323|reactome:R-DME-198693|reactome:R-DME-199418|reactome:R-DME-203615|reactome:R-DME-211163|reactome:R-DME-3769402|reactome:R-DME-389357|reactome:R-DME-389513|reactome:R-DME-392451|reactome:R-DME-450385|reactome:R-DME-450604|reactome:R-DME-5218920|reactome:R-DME-5628897|reactome:R-DME-6804759|reactome:R-DME-6811558|reactome:R-DME-69202|reactome:R-DME-69656|reactome:R-DME-8876198|reactome:R-DME-8948751|reactome:R-DME-9009391|reactome:R-DME-9604323|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9634638|ensemblmetazoa:FBgn0010379(gene)|ensemblmetazoa:FBtr0083228(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|refseq:NP_001287353.1|refseq:NP_001287354.1|dip:DIP-49060N	refseq:NP_611359.1|flybase:FBgn0262103|ensemblmetazoa:FBgn0262103(gene)|ensemblmetazoa:FBtr0304024(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 2D|comment:SIK3 Thr/Ser/Tyr mutations alter kinetics of interaction. Lsy-70 mutation makes SIK3 catalytically inactive.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/20	2014/10/16	rogid:O+TwU/5zv00wpwqXLxtrJrHk3lw7227	rogid:WTqlQVhnE96deUDryIIjWQPfAHc7227	intact-crc:25B487EB0073F0FF|rigid:HZPu8xwO0l4KKC+yWH3VLWzXwlU	false	-	mutation:281-281,293-293,401-401,486-486|mutation:70-70|ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8I9J6	uniprotkb:Q4QQA7	intact:EBI-4288282	intact:EBI-107683|ensemblmetazoa:FBpp0292993	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:q4qqa7_drome(display_long)|uniprotkb:Sik3(gene name)|psi-mi:Sik3(display_short)|uniprotkb:CG15072(gene name synonym)|uniprotkb:CG18604(gene name synonym)|uniprotkb:Dmel\CG42856(gene name synonym)|uniprotkb:EMK(gene name synonym)|uniprotkb:KIAA0999(gene name synonym)|uniprotkb:SIK(gene name synonym)|uniprotkb:SIK3(gene name synonym)|uniprotkb:CG42856(orf name)|uniprotkb:Dmel_CG42856(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288297|imex:IM-15737-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	refseq:NP_611359.1|flybase:FBgn0262103|ensemblmetazoa:FBgn0262103(gene)|ensemblmetazoa:FBtr0304024(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|comment:Ser mutations in HDAC4 alter kinetics of reaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:WTqlQVhnE96deUDryIIjWQPfAHc7227	intact-crc:22F631CA705E4BD6|rigid:waqs2us9ZyZJlFG7XUKEOFrJqqQ	false	mutation:242-242,576-576,751-751	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R1E0	uniprotkb:Q6NZM9	intact:EBI-1371343|uniprotkb:Q9JJW4|ensembl:ENSMUSP00000055308	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	psi-mi:foxo1_mouse(display_long)|uniprotkb:Foxo1(gene name)|psi-mi:Foxo1(display_short)|uniprotkb:Fkhr(gene name synonym)|uniprotkb:Foxo1a(gene name synonym)|uniprotkb:Forkhead box protein O1A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma(gene name synonym)	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288817|imex:IM-15737-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062713.2|ensembl:ENSMUSG00000044167(gene)|ensembl:ENSMUST00000053764(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030154"(cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|reactome:R-MMU-5687128|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-211163|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1902617"(response to fluoride)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|mint:Q9R1E0|reactome:R-MMU-198693	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hepatocyte)|taxid:10090(Mouse hepatocyte)	-	2011/06/20	2014/10/16	rogid:FZARINw0mWPO0HuwqULfIigXL2M10090	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	intact-crc:8DB1838C737E8C32|rigid:/J4vuPH8HZY44x+LkeSNufNMvyw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q95V55	uniprotkb:Q95V55	intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344	intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344	psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name)	psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name)	psi-mi:"MI:0889"(acetylase assay)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288360|imex:IM-15737-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638	refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638	go:"GO:0006473"(protein acetylation)|go:"GO:0016407"(acetyltransferase activity)	-	-	figure legend:Supp. Fig. 6G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/20	2014/10/16	rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227	rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227	intact-crc:45403A8E709D077C|rigid:N+FzNFse3+NOKMZ8wilfuYqpodA	false	sufficient binding region:95-198|glutathione s tranferase tag:?-?	sufficient binding region:95-198|glutathione s tranferase tag:?-?	-	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8I9J6	uniprotkb:Q95V55	intact:EBI-4288282	intact:EBI-500849|uniprotkb:Q7KF42|uniprotkb:Q95TK1|uniprotkb:Q9VFN8|ensemblmetazoa:FBpp0089343|ensemblmetazoa:FBpp0089344	psi-mi:q8i9j6_drome(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:HDAC4b(gene name synonym)|uniprotkb:CG1770(orf name)	psi-mi:foxo_drome(display_long)|uniprotkb:foxo(gene name)|psi-mi:foxo(display_short)|uniprotkb:Afx(gene name synonym)|uniprotkb:Protein FKHR(gene name synonym)|uniprotkb:CG3143(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2011)	pubmed:21565616|imex:IM-15737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4288348|imex:IM-15737-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0046872"(metal ion binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|flybase:FBgn0041210	refseq:NP_996204.1|refseq:NP_996205.1|flybase:FBgn0038197|refseq:NP_001262557.1|refseq:NP_650330.3|ensemblmetazoa:FBgn0038197(gene)|ensemblmetazoa:FBtr0082886(transcript)|ensemblmetazoa:FBtr0082887(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0040008"(regulation of growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048542"(lymph gland development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061965"(positive regulation of entry into reproductive diapause)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:2000130"(positive regulation of octopamine signaling pathway)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-110478|reactome:R-DME-1181150|reactome:R-DME-198693|reactome:R-DME-211163|reactome:R-DME-5687128|reactome:R-DME-5689880|reactome:R-DME-9607240|reactome:R-DME-9614399|reactome:R-DME-9617629|reactome:R-DME-9617828|reactome:R-DME-9634638	psi-mi:"MI:0469"(intact)|psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. FIg. 6A|comment:"Overexpression of constitutively active SIK3T.196E disrupted the FOXO:HDAC interaction"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/06/20	2014/10/16	rogid:ofXt3hf7jo2jUrX6egzC8K6kBQA7227	rogid:CU0MaKPPSCEHs3zCG/V6xQQOCS07227	intact-crc:DE71D86B2E28C89D|rigid:tE4F79JDn1fYgCaOtBIeVjGVD8U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)