#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P51799 uniprotkb:P11279 intact:EBI-8661056|ensembl:ENSRNOP00000023615|intact:MINT-4592777 intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40 psi-mi:clcn7_rat(display_long)|uniprotkb:Clcn7(gene name)|psi-mi:Clcn7(display_short)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)|uniprotkb:Chloride channel protein 7(gene name synonym) psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Leisle et al. (2011) mint:MINT-8188378|pubmed:21527911|imex:IM-15432|doi:10.1038/emboj.2011.137 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8661049|mint:MINT-8188386|imex:IM-15432-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|reactome:R-RNO-2672351|ensembl:ENSRNOG00000016976(gene)|ensembl:ENSRNOT00000023615(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|rgd:61836|refseq:NP_113756.1|mint:MINT-8188388(identity) ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N|mint:MINT-8188391(identity) go:"GO:0005764"(lysosome) function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport|comment:mint - figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/06/21 2014/10/16 rogid:o/hWxzO4njfVe/5oj2Axx+HWqiA10116 rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606 intact-crc:127C3327C47D9431|rigid:styTOd5mbqjStHJkitPvkNitgiU false ha tag:?-?(MINT-8188392) - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P51799 uniprotkb:Q8BGT0 intact:EBI-8661056|ensembl:ENSRNOP00000023615|intact:MINT-4592777 intact:EBI-987431|ensembl:ENSMUSP00000035516 psi-mi:clcn7_rat(display_long)|uniprotkb:Clcn7(gene name)|psi-mi:Clcn7(display_short)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)|uniprotkb:Chloride channel protein 7(gene name synonym) psi-mi:ostm1_mouse(display_long)|uniprotkb:Grey-lethal protein(gene name synonym)|uniprotkb:Ostm1(gene name)|psi-mi:Ostm1(display_short)|uniprotkb:Gl(gene name synonym)|uniprotkb:Chloride channel 7 beta subunit(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Leisle et al. (2011) mint:MINT-8188378|pubmed:21527911|imex:IM-15432|doi:10.1038/emboj.2011.137 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8661049|mint:MINT-8188386|imex:IM-15432-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|reactome:R-RNO-2672351|ensembl:ENSRNOG00000016976(gene)|ensembl:ENSRNOT00000023615(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|rgd:61836|refseq:NP_113756.1|mint:MINT-8188388(identity) ensembl:ENSMUSG00000038280(gene)|ensembl:ENSMUST00000040718(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030316"(osteoclast differentiation)|interpro:IPR019172|reactome:R-MMU-2672351|refseq:NP_766004.1|mint:MINT-8188412(identity) go:"GO:0005764"(lysosome) function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport|comment:mint - figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/06/21 2014/10/16 rogid:o/hWxzO4njfVe/5oj2Axx+HWqiA10116 rogid:+3jyZ9ycNub29k9QD5XVo0OMNyo10090 intact-crc:127C3327C47D9431|rigid:styTOd5mbqjStHJkitPvkNitgiU false ha tag:?-?(MINT-8188392) green fluorescent protein tag:?-?(MINT-8188413) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P51798 uniprotkb:P13473 intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9 intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639 psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym) psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Leisle et al. (2011) mint:MINT-8188378|pubmed:21527911|imex:IM-15432|doi:10.1038/emboj.2011.137 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8661095|mint:MINT-8188417|imex:IM-15432-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1|mint:MINT-8188420(identity) refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829|mint:MINT-8188424(identity) go:"GO:0005764"(lysosome) - - comment:homomint|comment:mint|figure legend:f5d sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/06/21 2014/10/16 rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606 rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606 intact-crc:0A486037C4E893F1|rigid:Wwq+Vwk6m79oUIa3IuHh+KCe8l0 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P51798 uniprotkb:Q8BGT0 intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9 intact:EBI-987431|ensembl:ENSMUSP00000035516 psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym) psi-mi:ostm1_mouse(display_long)|uniprotkb:Grey-lethal protein(gene name synonym)|uniprotkb:Ostm1(gene name)|psi-mi:Ostm1(display_short)|uniprotkb:Gl(gene name synonym)|uniprotkb:Chloride channel 7 beta subunit(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Leisle et al. (2011) mint:MINT-8188378|pubmed:21527911|imex:IM-15432|doi:10.1038/emboj.2011.137 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8661095|mint:MINT-8188417|imex:IM-15432-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1|mint:MINT-8188420(identity) ensembl:ENSMUSG00000038280(gene)|ensembl:ENSMUST00000040718(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030316"(osteoclast differentiation)|interpro:IPR019172|reactome:R-MMU-2672351|refseq:NP_766004.1|mint:MINT-8188426(identity) go:"GO:0005764"(lysosome) - - comment:homomint|comment:mint|figure legend:f5d sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/06/21 2014/10/16 rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606 rogid:+3jyZ9ycNub29k9QD5XVo0OMNyo10090 intact-crc:0A486037C4E893F1|rigid:Wwq+Vwk6m79oUIa3IuHh+KCe8l0 false - green fluorescent protein tag:?-?(MINT-8188427) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence)