#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P23528 uniprotkb:Q8WYL5 intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660 intact:EBI-1222387|uniprotkb:Q6P6C0|uniprotkb:Q8N9A7|uniprotkb:Q8WYL3|uniprotkb:Q8WYL4|uniprotkb:Q9P2P8|ensembl:ENSP00000315713 psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym) psi-mi:ssh1_human(display_long)|uniprotkb:SSH1(gene name)|psi-mi:SSH1(display_short)|uniprotkb:KIAA1298(gene name synonym)|uniprotkb:SSH1L(gene name synonym)|uniprotkb:SSH-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Barišić et al. (2011) mint:MINT-8185686|pubmed:21525957|imex:IM-15420|doi:10.1038/embor.2011.53 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8660499|mint:MINT-8185692|imex:IM-15420-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N|mint:MINT-8185695(identity) refseq:NP_001154802.1|refseq:NP_001154803.1|refseq:NP_061857.3|refseq:XP_016874982.1|refseq:XP_016874983.1|ensembl:ENSG00000084112(gene)|ensembl:ENST00000326495(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR014876(DEK C terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR027233|interpro:IPR029021|interpro:IPR043587|interpro:IPR043588|mint:MINT-8185694(identity) - - - figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/06/07 2014/10/16 rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606 rogid:mZqVdDjzQ5MkNi3P8+Z5siioiUY9606 intact-crc:CB98A8BDEBCA5D81|rigid:svIVCRztILaM2IZT7TQ2GBI4PRw false flag tag:?-?(MINT-8185706) mutation disrupting interaction:402-402(MINT-8185702)|glutathione s tranferase tag:?-?(MINT-8185697)|binding-associated region:1-461(MINT-8185700) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P23528 uniprotkb:Q8WYL5 intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660 intact:EBI-1222387|uniprotkb:Q6P6C0|uniprotkb:Q8N9A7|uniprotkb:Q8WYL3|uniprotkb:Q8WYL4|uniprotkb:Q9P2P8|ensembl:ENSP00000315713 psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym) psi-mi:ssh1_human(display_long)|uniprotkb:SSH1(gene name)|psi-mi:SSH1(display_short)|uniprotkb:KIAA1298(gene name synonym)|uniprotkb:SSH1L(gene name synonym)|uniprotkb:SSH-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Barišić et al. (2011) mint:MINT-8185686|pubmed:21525957|imex:IM-15420|doi:10.1038/embor.2011.53 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8660524|mint:MINT-8185710|imex:IM-15420-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N|mint:MINT-8185720(identity) refseq:NP_001154802.1|refseq:NP_001154803.1|refseq:NP_061857.3|refseq:XP_016874982.1|refseq:XP_016874983.1|ensembl:ENSG00000084112(gene)|ensembl:ENST00000326495(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR014876(DEK C terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR027233|interpro:IPR029021|interpro:IPR043587|interpro:IPR043588|mint:MINT-8185712(identity) - - - figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/06/07 2014/10/16 rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606 rogid:mZqVdDjzQ5MkNi3P8+Z5siioiUY9606 intact-crc:0B818705D5DAB84B|rigid:svIVCRztILaM2IZT7TQ2GBI4PRw false flag tag:?-?(MINT-8185721) mutation disrupting interaction:402-402(MINT-8185713)|glutathione s tranferase tag:?-?(MINT-8185727)|binding-associated region:1-461(MINT-8185715) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot)