#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q5VWP3 uniprotkb:P02545 intact:EBI-3895430|uniprotkb:B7Z2N0|uniprotkb:D6RE05|uniprotkb:Q96H08|uniprotkb:Q96NF7|ensembl:ENSP00000274897 intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771 psi-mi:mlip_human(display_long)|uniprotkb:C6orf142(gene name synonym)|uniprotkb:MLIP(gene name)|psi-mi:MLIP(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3895433|imex:IM-16933-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_612636.2|ensembl:ENSG00000146147(gene)|ensembl:ENST00000274897(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|refseq:NP_001268675.1|refseq:NP_001268676.1|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331 refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N - - - figure legend:fig1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/10 2014/10/16 rogid:kb1D/ZWf0o4d1hc3yL+8nNJohmU9606 rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606 intact-crc:75A4F83AC45C1870|rigid:wIK8IFwM6ZAEbZXE5uT8vvCntXA false - sufficient binding region:1-230 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q5VWP3 uniprotkb:P02545 intact:EBI-3895430|uniprotkb:B7Z2N0|uniprotkb:D6RE05|uniprotkb:Q96H08|uniprotkb:Q96NF7|ensembl:ENSP00000274897 intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771 psi-mi:mlip_human(display_long)|uniprotkb:C6orf142(gene name synonym)|uniprotkb:MLIP(gene name)|psi-mi:MLIP(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3895450|imex:IM-16933-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_612636.2|ensembl:ENSG00000146147(gene)|ensembl:ENST00000274897(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|refseq:NP_001268675.1|refseq:NP_001268676.1|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331 refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N - - - figure legend:fig1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/10 2014/10/16 rogid:kb1D/ZWf0o4d1hc3yL+8nNJohmU9606 rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606 intact-crc:1B237694A724DFFF|rigid:wIK8IFwM6ZAEbZXE5uT8vvCntXA false - necessary binding region:1-120 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FW52 uniprotkb:P02545 intact:EBI-3895556|uniprotkb:Q9D6X9|ensembl:ENSMUSP00000034910 intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771 psi-mi:mlip_mouse(display_long)|uniprotkb:Mlip(gene name)|psi-mi:Mlip(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym) psi-mi:"MI:0096"(pull down) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-3895559|imex:IM-16933-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_081426.1|ensembl:ENSMUSG00000032355(gene)|ensembl:ENSMUST00000034910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331|mint:Q5FW52 refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N - - - figure legend:4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/10 2014/10/16 rogid:BxEbvPbj3uoTjB+cjZUXTW9hmUQ10090 rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606 intact-crc:A78A1867AA3BBFD8|rigid:wywL0dOEib9Ofglvxeel8BCP3U0 false his tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:1-230 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5FW52 uniprotkb:P48678 intact:EBI-3895556|uniprotkb:Q9D6X9|ensembl:ENSMUSP00000034910 intact:EBI-299212|ensembl:ENSMUSP00000029699|uniprotkb:P11516|uniprotkb:P97859|uniprotkb:Q3TIH0|uniprotkb:Q3TTS8|uniprotkb:Q3UCA0|uniprotkb:Q3UCJ8|uniprotkb:Q91WF2|uniprotkb:Q9DC21|uniprotkb:B3RH23|uniprotkb:B3RH24|uniprotkb:Q3U733|uniprotkb:Q3U7I5|uniprotkb:Q3UCU3 psi-mi:mlip_mouse(display_long)|uniprotkb:Mlip(gene name)|psi-mi:Mlip(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:lmna_mouse(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3895570|imex:IM-16933-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_081426.1|ensembl:ENSMUSG00000032355(gene)|ensembl:ENSMUST00000034910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331|mint:Q5FW52 go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|ensembl:ENSMUSG00000028063(gene)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|ensembl:ENSMUST00000029699(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P48678|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|rcsb pdb:1UFG|reactome:R-MMU-352238|reactome:R-MMU-4419969|refseq:NP_001002011.2|refseq:NP_001104572.1|refseq:NP_062263.1|refseq:XP_006501136.1|dip:DIP-31384N - - - figure legend:4C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue]) - 2011/05/10 2014/10/16 rogid:BxEbvPbj3uoTjB+cjZUXTW9hmUQ10090 rogid:bJz9o/dZoD9E4CRP1FLYihybpwA10090 intact-crc:413F8663C91985ED|rigid:VFEmq0+gL6lYz/P3ZVrLikGUMWo false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q5FW52 uniprotkb:P29590 intact:EBI-3895556|uniprotkb:Q9D6X9|ensembl:ENSMUSP00000034910 intact:EBI-295890|ensembl:ENSP00000268058|uniprotkb:P29591|uniprotkb:P29592|uniprotkb:P29593|uniprotkb:Q00755|uniprotkb:Q96S41|intact:EBI-779712|intact:EBI-1210702|intact:EBI-870812|uniprotkb:Q15959|uniprotkb:Q59FP9|uniprotkb:Q8WUA0|uniprotkb:Q9BPW2|uniprotkb:Q9BWP7|uniprotkb:Q9BZX6|uniprotkb:Q9BZX7|uniprotkb:Q9BZX8|uniprotkb:Q9BZX9|uniprotkb:Q9BZY0|uniprotkb:Q9BZY2|uniprotkb:Q9BZY3|uniprotkb:E9PBR7 psi-mi:mlip_mouse(display_long)|uniprotkb:Mlip(gene name)|psi-mi:Mlip(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:pml_human(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3895585|imex:IM-16933-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_081426.1|ensembl:ENSMUSG00000032355(gene)|ensembl:ENSMUST00000034910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331|mint:Q5FW52 ensembl:ENST00000268058(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000140464(gene)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006605"(protein targeting)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032938"(negative regulation of translation in response to oxidative stress)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|rcsb pdb:2MWX|rcsb pdb:4WJN|rcsb pdb:4WJO|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|rcsb pdb:5YUF|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:6IMQ|rcsb pdb:6UYO|rcsb pdb:6UYP|interpro:IPR001841(Zinc finger, RING-type)|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:6UYT|rcsb pdb:6UYU|rcsb pdb:6UYV|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-6804758|reactome:R-HSA-877300|reactome:R-HSA-8934593|reactome:R-HSA-8948747|reactome:R-HSA-9609690|reactome:R-HSA-9616222|interpro:IPR021978|mint:P29590|rcsb pdb:1BOR|rcsb pdb:2MVW|refseq:NP_002666.1|refseq:NP_150241.2|refseq:NP_150242.1|refseq:NP_150243.2|refseq:NP_150247.2|refseq:NP_150249.1|refseq:NP_150250.2|refseq:NP_150252.1|refseq:NP_150253.2|dip:DIP-33053N go:"GO:0016605"(PML body) - - figure legend:5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2011/05/10 2014/10/16 rogid:BxEbvPbj3uoTjB+cjZUXTW9hmUQ10090 rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606 intact-crc:12DCA226636549B8|rigid:8IvciqpbKlgH2PXH7EYTAXS/6TE false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q5FW52 uniprotkb:P48678 intact:EBI-3895556|uniprotkb:Q9D6X9|ensembl:ENSMUSP00000034910 intact:EBI-299212|ensembl:ENSMUSP00000029699|uniprotkb:P11516|uniprotkb:P97859|uniprotkb:Q3TIH0|uniprotkb:Q3TTS8|uniprotkb:Q3UCA0|uniprotkb:Q3UCJ8|uniprotkb:Q91WF2|uniprotkb:Q9DC21|uniprotkb:B3RH23|uniprotkb:B3RH24|uniprotkb:Q3U733|uniprotkb:Q3U7I5|uniprotkb:Q3UCU3 psi-mi:mlip_mouse(display_long)|uniprotkb:Mlip(gene name)|psi-mi:Mlip(display_short)|uniprotkb:Muscular-enriched A-type laminin-interacting protein(gene name synonym)|uniprotkb:Cardiac Isl1-interacting protein(gene name synonym)|uniprotkb:Cip(gene name synonym) psi-mi:lmna_mouse(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ahmady et al. (2011) pubmed:21498514|imex:IM-16933 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3895581|imex:IM-16933-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_081426.1|ensembl:ENSMUSG00000032355(gene)|ensembl:ENSMUST00000034910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016605"(PML body)|go:"GO:0031981"(nuclear lumen)|go:"GO:0042383"(sarcolemma)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR029331|mint:Q5FW52 go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|ensembl:ENSMUSG00000028063(gene)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|ensembl:ENSMUST00000029699(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P48678|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|rcsb pdb:1UFG|reactome:R-MMU-352238|reactome:R-MMU-4419969|refseq:NP_001002011.2|refseq:NP_001104572.1|refseq:NP_062263.1|refseq:XP_006501136.1|dip:DIP-31384N go:"GO:0005635"(nuclear envelope) - - figure legend:5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2011/05/10 2014/10/16 rogid:BxEbvPbj3uoTjB+cjZUXTW9hmUQ10090 rogid:bJz9o/dZoD9E4CRP1FLYihybpwA10090 intact-crc:589CDD1FF0E7FD69|rigid:VFEmq0+gL6lYz/P3ZVrLikGUMWo false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)