#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WTK7	uniprotkb:P06240	intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8	intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65	psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym)	psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627444|mint:MINT-8202372|imex:IM-15824-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N|mint:MINT-8202374(identity)	ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374|mint:MINT-8202375(identity)	-	comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor"	-	figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090	rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090	intact-crc:73790C04CD9A5100|rigid:D/ExX0NV6JOkjsnFdgoI7ofktJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK7	uniprotkb:O54957	intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8	intact:EBI-6390034|ensembl:ENSMUSP00000032997	psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym)	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627520|mint:MINT-8202381|imex:IM-15824-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N|mint:MINT-8202383(identity)	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1|mint:MINT-8202385(identity)	-	comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor"	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	intact-crc:67F5E9E87AC58BD0|rigid:uB1Uei6Lie8qfq/xnyzN/ymcv8I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK7	uniprotkb:Q62077	intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627532|mint:MINT-8202459|imex:IM-15824-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N|mint:MINT-8202461(identity)	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N|mint:MINT-8202463(identity)	-	comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor"	-	figure legend:f6c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:B1692D73501DFCEE|rigid:6dVkknkPOTd7yl29APSOj81M6oQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54957	uniprotkb:Q62077	intact:EBI-6390034|ensembl:ENSMUSP00000032997	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627544|mint:MINT-8202468|imex:IM-15824-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1|mint:MINT-8202472(identity)	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N|mint:MINT-8202470(identity)	-	-	-	figure legend:f6d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:D7778D979E8F7DE6|rigid:4btfOAaHGD2T31rhCI6rQnbPzrU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54957	uniprotkb:Q60631	intact:EBI-6390034|ensembl:ENSMUSP00000032997	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627568|mint:MINT-8204239|imex:IM-15824-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1|mint:MINT-8204241(identity)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-8204243(identity)	imex:IM_15824-6(imex secondary)	-	-	figure legend:f6d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:7B1354BA95720BE1|rigid:ZHPvZPWTpw+vo8iDoqGqCzlmr1s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60787	uniprotkb:O54957	intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0	intact:EBI-6390034|ensembl:ENSMUSP00000032997	psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627556|mint:MINT-8204231|imex:IM-15824-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2|mint:MINT-8204235(identity)	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1|mint:MINT-8204233(identity)	-	-	-	figure legend:f6d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	intact-crc:0192EC5D748C8F3D|rigid:PpfZVfjHS0bU1MlZrs+IcZu4h3s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK7	uniprotkb:O54957	intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8	intact:EBI-6390034|ensembl:ENSMUSP00000032997	psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym)	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Cao et al. (2011)	mint:MINT-8184311|pubmed:21487392|imex:IM-15824|doi:10.1038/emboj.2011.116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8627595|mint:MINT-8202478|imex:IM-15824-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N|mint:MINT-8202480(identity)	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1|mint:MINT-8202482(identity)	-	comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor"	-	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/07/28	2014/10/16	rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	intact-crc:3A9AAB3262C27771|rigid:uB1Uei6Lie8qfq/xnyzN/ymcv8I	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)