#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:47785" chebi:"CHEBI:18420" intact:EBI-1554642 intact:EBI-967760 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:"magnesium(2+)"(display_short)|psi-mi:"CHEBI:18420"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954294|pdbe:3qf7|imex:IM-15801-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Supp. Table 2|3d-resolution:1.9A|3d-r-factors:Rworking = 15.7% Rfree = 19.1%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - - intact-crc:0BA4D861752AD372 false - - 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:Q9X1X0 intact:EBI-1554642 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0114"(x-ray crystallography) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954294|pdbe:3qf7|imex:IM-15801-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 - - - figure legend:Supp. Table 2|3d-resolution:1.9A|3d-r-factors:Rworking = 15.7% Rfree = 19.1%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:0BA4D861752AD372 false - sufficient binding region:343-385 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:Q9X1X1 intact:EBI-1554642 intact:EBI-3954207|ensemblbacteria:AAD36703 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:"MI:0114"(x-ray crystallography) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954294|pdbe:3qf7|imex:IM-15801-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M - - - figure legend:Supp. Table 2|3d-resolution:1.9A|3d-r-factors:Rworking = 15.7% Rfree = 19.1%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 intact-crc:0BA4D861752AD372 false - sufficient binding region:1-190,686-852 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9X1X1 uniprotkb:Q9X1X0 intact:EBI-3954207|ensemblbacteria:AAD36703 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0114"(x-ray crystallography) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954210|imex:IM-15801-1|pdbe:3qg5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 - - - figure legend:Supp. Table 1|3d-resolution:3.4A|3d-r-factors:Rworking = 25.8% Rfree = 29.5%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:B2D377740F845BE7|rigid:fqXXlTB8WnQsjsueKLP+ZeSbJlg false sufficient binding region:1-190,686-852 sufficient binding region:8-385 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9X1X1 uniprotkb:Q9X1X0 intact:EBI-3954207|ensemblbacteria:AAD36703 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0826"(x ray scattering) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954335|imex:IM-15801-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:9E359EA495B558D9|rigid:fqXXlTB8WnQsjsueKLP+ZeSbJlg false sufficient binding region:1-190,686-852 sufficient binding region:343-385 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:27575" uniprotkb:Q9X1X0 intact:EBI-1209042 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:adenosine 5'-[gamma-thio]triphosphate(display_short)|psi-mi:"CHEBI:27575"(display_long) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0826"(x ray scattering) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954322|imex:IM-15801-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 - - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:AB40139B955CCCCA false - sufficient binding region:343-385 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:27575" uniprotkb:Q9X1X1 intact:EBI-1209042 intact:EBI-3954207|ensemblbacteria:AAD36703 psi-mi:adenosine 5'-[gamma-thio]triphosphate(display_short)|psi-mi:"CHEBI:27575"(display_long) psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:"MI:0826"(x ray scattering) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954322|imex:IM-15801-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M - - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 intact-crc:AB40139B955CCCCA false - sufficient binding region:1-190,686-852 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:Q9X1X0 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0880"(atpase assay) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954461|imex:IM-15801-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 go:"GO:0006200"(obsolete ATP catabolic process)|go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:Supp. Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:AF8D87856E6D7F26 false - sufficient binding region:343-385|mutation increasing interaction:291-291 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:Q9X1X1 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-3954207|ensemblbacteria:AAD36703 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:"MI:0880"(atpase assay) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954461|imex:IM-15801-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M go:"GO:0006200"(obsolete ATP catabolic process)|go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:Supp. Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 intact-crc:AF8D87856E6D7F26 false - sufficient binding region:1-190,686-852|his tag:?-?|mutation increasing interaction:760-760 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9X1X1 uniprotkb:Q9X1X1 intact:EBI-3954207|ensemblbacteria:AAD36703 intact:EBI-3954207|ensemblbacteria:AAD36703 psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:"MI:0030"(cross-linking study) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954355|imex:IM-15801-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3C|comment:crosslinking efficiency substantially increases further in the presence of both ATPgammaS and DNA.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 intact-crc:7110CD1D7FA42DD4|rigid:0aapIb3lh/EF7qbILx5TPlM43S8 false mutation:31-31,806-806|his tag:?-?|sufficient binding region:1-190,686-852 mutation:31-31,806-806|his tag:?-?|sufficient binding region:1-190,686-852 2 0 psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9X1X1 uniprotkb:Q9X1X0 intact:EBI-3954207|ensemblbacteria:AAD36703 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0071"(molecular sieving) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954413|imex:IM-15801-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 3A-3D|comment:"Expt +/- cross-linking agents suggest there is no interactions between Mre11:Rad50 heterotetramers."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:DFD6D3484B9705F6|rigid:fqXXlTB8WnQsjsueKLP+ZeSbJlg false sufficient binding region:1-190,686-852|his tag:?-? sufficient binding region:8-385 2 2 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-2307713 uniprotkb:Q9X1X0 - intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:phix174_dsdna(display_short)|psi-mi:EBI-2307713(display_long) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:10847(bpphx)|taxid:10847(Enterobacteria phage phiX174) taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954441|imex:IM-15801-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 - - - figure legend:Supp. Fig. 3E|comment:"Expt +/- cross-linking agents suggest there is no interactions between Mre11:Rad50 heterotetramers."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:CF7B1A5482117D6B false - sufficient binding region:8-385 - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-2307713 uniprotkb:Q9X1X1 - intact:EBI-3954207|ensemblbacteria:AAD36703 psi-mi:phix174_dsdna(display_short)|psi-mi:EBI-2307713(display_long) psi-mi:rad50_thema(display_long)|uniprotkb:rad50(gene name)|psi-mi:rad50(display_short)|uniprotkb:TM_1636(locus name) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:10847(bpphx)|taxid:10847(Enterobacteria phage phiX174) taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954441|imex:IM-15801-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:WP_004082116.1|interpro:IPR003959(AAA ATPase, core)|interpro:IPR029012|interpro:IPR013134(Zinc hook, Rad50)|refseq:NP_229436.1|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THO|ensemblbacteria:AAD36703(transcript)|ensemblbacteria:TM_1636(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR027417|rcsb pdb:4W9M - - - figure legend:Supp. Fig. 3E|comment:"Expt +/- cross-linking agents suggest there is no interactions between Mre11:Rad50 heterotetramers."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 - rogid:J0zIArg5aqxh9q6ylw1z/GuM9Zo243274 intact-crc:CF7B1A5482117D6B false - sufficient binding region:1-190,686-852|his tag:?-? - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9X1X0 uniprotkb:Q9X1X0 intact:EBI-3954204|ensemblbacteria:AAD36702 intact:EBI-3954204|ensemblbacteria:AAD36702 psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:q9x1x0_thema(display_long)|uniprotkb:sbcD(gene name)|psi-mi:sbcD(display_short)|uniprotkb:TM_1635(locus name) psi-mi:"MI:0030"(cross-linking study) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954518|imex:IM-15801-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 rcsb pdb:6X1Y|rcsb pdb:6X1Z|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR004593(Exonuclease SbcD)|refseq:NP_229435.1|rcsb pdb:2Q8U|rcsb pdb:3QF7|rcsb pdb:3QG5|rcsb pdb:3THN|rcsb pdb:3THO|rcsb pdb:4NZV|rcsb pdb:4O24|rcsb pdb:4O43|rcsb pdb:4O4K|rcsb pdb:4O5G|ensemblbacteria:AAD36702(transcript)|ensemblbacteria:TM_1635(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006274"(DNA replication termination)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6ASC|interpro:IPR029052|rcsb pdb:4W9M|interpro:IPR041796 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 rogid:beLnzLNGTIQQCi/o+6cckGOl/9Q243274 intact-crc:E5C34B1D329BE49D|rigid:9wa28BlBbY2UoG0xRR6PKPa+PQY false mutation:110-110 mutation:110-110 2 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8U1N9 uniprotkb:Q8U1N9 intact:EBI-2014945|ensemblbacteria:AAL81290 intact:EBI-2014945|ensemblbacteria:AAL81290 psi-mi:mre11_pyrfu(display_long)|uniprotkb:mre11(gene name)|psi-mi:mre11(display_short)|uniprotkb:pfMre11(gene name synonym)|uniprotkb:PF1166(locus name) psi-mi:mre11_pyrfu(display_long)|uniprotkb:mre11(gene name)|psi-mi:mre11(display_short)|uniprotkb:pfMre11(gene name synonym)|uniprotkb:PF1166(locus name) psi-mi:"MI:0030"(cross-linking study) Lammens et al. (2011) pubmed:21458667|imex:IM-15801 taxid:186497(pyrfu)|taxid:186497(Pyrococcus furiosus) taxid:186497(pyrfu)|taxid:186497(Pyrococcus furiosus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3954544|imex:IM-15801-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-52386N|ensemblbacteria:AAL81290(transcript)|ensemblbacteria:PF1166(gene)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045027"(DNA end binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR029052|interpro:IPR032885|interpro:IPR041796|rcsb pdb:1II7|rcsb pdb:1S8E|rcsb pdb:3DSC|rcsb pdb:3DSD|rcsb pdb:3QKR|rcsb pdb:3QKS|rcsb pdb:3QKU|rcsb pdb:4HD0 dip:DIP-52386N|ensemblbacteria:AAL81290(transcript)|ensemblbacteria:PF1166(gene)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045027"(DNA end binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR029052|interpro:IPR032885|interpro:IPR041796|rcsb pdb:1II7|rcsb pdb:1S8E|rcsb pdb:3DSC|rcsb pdb:3DSD|rcsb pdb:3QKR|rcsb pdb:3QKS|rcsb pdb:3QKU|rcsb pdb:4HD0 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/05/27 2014/10/16 rogid:Mgf8L+4uDXb3qMP0/Mbju9KE7AM186497 rogid:Mgf8L+4uDXb3qMP0/Mbju9KE7AM186497 intact-crc:5AF293D14FE4B13C|rigid:agNZ3gVHID3qZxV9jHz/m6MxSJI false mutation:101-101 mutation:101-101 2 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)