#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13794	uniprotkb:Q07820	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370352|imex:IM-16929-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N	-	-	-	figure legend:1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.4x10^-9 ~0.8(molar)	2011/08/16	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606	intact-crc:C852DB11F4903BCF|rigid:qTB/l1tWrQOlDFLo7aUl+wpJf8Q	false	his tag:n-n|tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13794	uniprotkb:P10415-1	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-4370304|ensembl:ENSP00000329623|ensembl:ENSP00000381185	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:p10415-1(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370379|imex:IM-16929-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|intact:EBI-77694(isoform-parent)	-	-	-	figure legend:2a and 2d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/08/16	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:D58D20FC338E3E15|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	sufficient binding region:18-43	glutathione s tranferase tag:n-n|mutation disrupting interaction:146-146	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13794	uniprotkb:P10415-1	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-4370304|ensembl:ENSP00000329623|ensembl:ENSP00000381185	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:p10415-1(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370302|imex:IM-16929-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|intact:EBI-77694(isoform-parent)	-	-	-	figure legend:1b, 1d, s1b, S1c and 1e|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:25.0x10^-8 ~1.5(molar)	2011/08/16	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:CADCD38953E819F9|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	his tag:n-n|tag:?-?	mutation decreasing interaction:59-59,117-117|glutathione s tranferase tag:n-n|mutation increasing interaction:31-31,60-60|mutation increasing interaction:48-48,129-129	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13794	uniprotkb:Q07817-1	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370368|imex:IM-16929-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	figure legend:S1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-8 ~4.0(molar)	2011/08/16	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:0AA60FDE16168DFC|rigid:EoDkJBBa/tBC/HRY/PHJQpOK8+8	false	tag:?-?|his tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10415-1	uniprotkb:Q13794	intact:EBI-4370304|ensembl:ENSP00000329623|ensembl:ENSP00000381185	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:p10415-1(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370422|imex:IM-16929-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|intact:EBI-77694(isoform-parent)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	figure legend:3c and 3e|agonist:Proteasome-inhibitor bortemozid is required for the interaction to take place.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2011/08/16	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:B3B20B10AE2571FF|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	mutation increasing interaction:31-31,60-60|tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10415	uniprotkb:Q13794	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370439|imex:IM-16929-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	figure legend:3d|agonist:Proteasome inhibitor MG132 is required for the interaction to take place.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2011/08/16	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:BFA873E4F7AF5C91|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	-	tag:?-?|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10415	uniprotkb:Q13794	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370506|imex:IM-16929-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	figure legend:3f|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rl)|taxid:9606(Homo sapiens)	-	2011/08/16	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:68B4B747B5A944FA|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10415	uniprotkb:Q13794	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370520|imex:IM-16929-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	figure legend:"3g (right)"|agonist:Camptothecin, a topoisomerase I poison that induces apoptosis, was required for the interaction to take place.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2011/08/16	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:6C9C36BECE9DAD83|rigid:xDVrBBYzwvuahugAPVr3MTVu9IE	false	tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13794	uniprotkb:Q07820	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Smith et al. (2011)	pubmed:21454712|imex:IM-16929	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4370530|imex:IM-16929-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N	-	-	-	figure legend:"3g (left)"|agonist:Camptothecin, a topoisomerase I poison that induces apoptosis, was required for the interaction to take place.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2011/08/16	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606	intact-crc:BA4E8BD28336B79C|rigid:qTB/l1tWrQOlDFLo7aUl+wpJf8Q	false	-	tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)