#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62406	uniprotkb:P22366	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891321|imex:IM-15788-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|agonist:"LPS (0-90mins)"|comment:interaction is reduced in MHC class II deficient murine macrophages|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:D4A7C9D1EBA44994|rigid:1lx6v94tCfUxZT/JUOgDeI3crAg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80UF7	uniprotkb:Q9WUN2	intact:EBI-3649271|uniprotkb:Q3UDB7|uniprotkb:Q3UP66|uniprotkb:Q6P6J2|uniprotkb:Q8CIB7|uniprotkb:Q8JZV0|ensembl:ENSMUSP00000055104	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:tcam1_mouse(display_long)|uniprotkb:Ticam1(gene name)|psi-mi:Ticam1(display_short)|uniprotkb:Trif(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891327|imex:IM-15788-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_778154.1|dip:DIP-60033N|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|reactome:R-MMU-140534|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-975163|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|ensembl:ENSMUSG00000047123(gene)|ensembl:ENSMUST00000058136(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4E|agonist:"LPS (0-90mins)"|comment:interaction is reduced in MHC class II deficient murine macrophages|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:APXUJZZMj/mRQbYaeJ+MapQPe2Y10090	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	intact-crc:B5286104B669BC71|rigid:/GsYcGipd6O5QB/zvBG6X79gbsc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35991	uniprotkb:Q80UF7	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-3649271|uniprotkb:Q3UDB7|uniprotkb:Q3UP66|uniprotkb:Q6P6J2|uniprotkb:Q8CIB7|uniprotkb:Q8JZV0|ensembl:ENSMUSP00000055104	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:tcam1_mouse(display_long)|uniprotkb:Ticam1(gene name)|psi-mi:Ticam1(display_short)|uniprotkb:Trif(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891333|imex:IM-15788-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_778154.1|dip:DIP-60033N|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|reactome:R-MMU-140534|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-975163|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|ensembl:ENSMUSG00000047123(gene)|ensembl:ENSMUST00000058136(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7A|agonist:"LPS (15-90mins)"|comment:interaction reduced in MHC class II deficient murine macrophages|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:APXUJZZMj/mRQbYaeJ+MapQPe2Y10090	intact-crc:A0CB834D4D09CD86|rigid:eUeflQHImKtH257tOpKim9U2k48	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35991	uniprotkb:P22366	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891333|imex:IM-15788-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7A|agonist:"LPS (15-90mins)"|comment:interaction reduced in MHC class II deficient murine macrophages|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:A0CB834D4D09CD86|rigid:eUeflQHImKtH257tOpKim9U2k48	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27512	uniprotkb:P35991	intact:EBI-525742|uniprotkb:Q3TSL2|uniprotkb:Q3U799|uniprotkb:Q3U7C9|uniprotkb:Q3UBH3|uniprotkb:Q542B1|uniprotkb:Q8K2X6|uniprotkb:Q3TS33|uniprotkb:Q99NE0|uniprotkb:Q99NE1|uniprotkb:Q99NE2|uniprotkb:Q99NE3|ensembl:ENSMUSP00000017799	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:tnr5_mouse(display_long)|uniprotkb:CD40L receptor(gene name synonym)|uniprotkb:B-cell surface antigen CD40(gene name synonym)|uniprotkb:Bp50(gene name synonym)|uniprotkb:Cd40(gene name)|psi-mi:Cd40(display_short)|uniprotkb:Tnfrsf5(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891340|imex:IM-15788-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733805.1|refseq:NP_035741.2|refseq:NP_733803.2|refseq:NP_733804.1|dip:DIP-33295N|ensembl:ENSMUSG00000017652(gene)|ensembl:ENSMUST00000017799(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043196"(varicosity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:1901652"(response to peptide)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020435|interpro:IPR034021|mint:P27512|reactome:R-MMU-198933|reactome:R-MMU-5668541|reactome:R-MMU-5676594	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S12A|agonist:"LPS (5-15mins)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:sbtmpefZccnV+F7arDjo6INyfi010090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:889749EE032FF335|rigid:/i/qpVdAbr33ByCGsS0d9EWTc5U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35991	uniprotkb:P27512	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-525742|uniprotkb:Q3TSL2|uniprotkb:Q3U799|uniprotkb:Q3U7C9|uniprotkb:Q3UBH3|uniprotkb:Q542B1|uniprotkb:Q8K2X6|uniprotkb:Q3TS33|uniprotkb:Q99NE0|uniprotkb:Q99NE1|uniprotkb:Q99NE2|uniprotkb:Q99NE3|ensembl:ENSMUSP00000017799	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:tnr5_mouse(display_long)|uniprotkb:CD40L receptor(gene name synonym)|uniprotkb:B-cell surface antigen CD40(gene name synonym)|uniprotkb:Bp50(gene name synonym)|uniprotkb:Cd40(gene name)|psi-mi:Cd40(display_short)|uniprotkb:Tnfrsf5(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891353|imex:IM-15788-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_733805.1|refseq:NP_035741.2|refseq:NP_733803.2|refseq:NP_733804.1|dip:DIP-33295N|ensembl:ENSMUSG00000017652(gene)|ensembl:ENSMUST00000017799(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043196"(varicosity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:1901652"(response to peptide)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020435|interpro:IPR034021|mint:P27512|reactome:R-MMU-198933|reactome:R-MMU-5668541|reactome:R-MMU-5676594	go:"GO:0005768"(endosome)	-	-	figure legend:Fig. 6E|agonist:"LPS(15mins)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2011/04/21	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:sbtmpefZccnV+F7arDjo6INyfi010090	intact-crc:5BD64D534D207EC2|rigid:/i/qpVdAbr33ByCGsS0d9EWTc5U	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q80UF7	uniprotkb:P35991	intact:EBI-3649271|uniprotkb:Q3UDB7|uniprotkb:Q3UP66|uniprotkb:Q6P6J2|uniprotkb:Q8CIB7|uniprotkb:Q8JZV0|ensembl:ENSMUSP00000055104	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:tcam1_mouse(display_long)|uniprotkb:Ticam1(gene name)|psi-mi:Ticam1(display_short)|uniprotkb:Trif(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891367|imex:IM-15788-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_778154.1|dip:DIP-60033N|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|reactome:R-MMU-140534|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-975163|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|ensembl:ENSMUSG00000047123(gene)|ensembl:ENSMUST00000058136(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/04/21	2014/10/16	rogid:APXUJZZMj/mRQbYaeJ+MapQPe2Y10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:657C1949EAC55046|rigid:tQPvm/JBkiJ2hO63T9fetR/LAtI	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35991	uniprotkb:P22366	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891375|imex:IM-15788-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/04/21	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:8BBABD26AE9035F0|rigid:HsJ9LaC0jGqfSgJDzLZe2xWqOdw	false	ha tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35991	uniprotkb:P27512	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-525742|uniprotkb:Q3TSL2|uniprotkb:Q3U799|uniprotkb:Q3U7C9|uniprotkb:Q3UBH3|uniprotkb:Q542B1|uniprotkb:Q8K2X6|uniprotkb:Q3TS33|uniprotkb:Q99NE0|uniprotkb:Q99NE1|uniprotkb:Q99NE2|uniprotkb:Q99NE3|ensembl:ENSMUSP00000017799	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:tnr5_mouse(display_long)|uniprotkb:CD40L receptor(gene name synonym)|uniprotkb:B-cell surface antigen CD40(gene name synonym)|uniprotkb:Bp50(gene name synonym)|uniprotkb:Cd40(gene name)|psi-mi:Cd40(display_short)|uniprotkb:Tnfrsf5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2011)	pubmed:21441935|imex:IM-15788	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3891391|imex:IM-15788-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_733805.1|refseq:NP_035741.2|refseq:NP_733803.2|refseq:NP_733804.1|dip:DIP-33295N|ensembl:ENSMUSG00000017652(gene)|ensembl:ENSMUST00000017799(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043196"(varicosity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:1901652"(response to peptide)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020435|interpro:IPR034021|mint:P27512|reactome:R-MMU-198933|reactome:R-MMU-5668541|reactome:R-MMU-5676594	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S12C|agonist:"LPS (15mins)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/04/21	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:sbtmpefZccnV+F7arDjo6INyfi010090	intact-crc:6B4E7B5F4751A16F|rigid:/i/qpVdAbr33ByCGsS0d9EWTc5U	false	ha tag:?-?|necessary binding region:3..3-133..133(IPR001849)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)