#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:B1PKZ2 uniprotkb:P32241 intact:EBI-5327925|uniprotkb:O19673|uniprotkb:O19695|uniprotkb:O19794|uniprotkb:O19795|uniprotkb:O43907|uniprotkb:O77938|uniprotkb:O98010|uniprotkb:P10315|uniprotkb:P79505|uniprotkb:Q9MYA5|uniprotkb:Q9MYC4|uniprotkb:Q9TQG7|uniprotkb:Q9TQN5|uniprotkb:Q9UIN2 intact:EBI-3917984|uniprotkb:A5JUT9|uniprotkb:Q15871|uniprotkb:Q6P2M6|uniprotkb:B3KPV1|uniprotkb:B4DGI4|uniprotkb:F5H1F5|uniprotkb:G3V0I1|uniprotkb:B4DEB5|ensembl:ENSP00000327246 psi-mi:1a68_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-68(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-28 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*68(gene name synonym) psi-mi:vipr1_human(display_long)|uniprotkb:VIPR1(gene name)|psi-mi:VIPR1(display_short)|uniprotkb:Pituitary adenylate cyclase-activating polypeptide type II receptor(gene name synonym)|uniprotkb:VPAC1(gene name synonym) psi-mi:"MI:0013"(biophysical) Fabian et al. (2011) mint:MINT-8144484|pubmed:21414141|imex:IM-16701|mint:fj-10-1134 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8610605|mint:MINT-8144492|imex:IM-16701-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HWZ|rcsb pdb:4HX1|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:6EI2|uniprotkb:P01891(see-also)|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:1HSB|rcsb pdb:1TMC|rcsb pdb:2HLA|ensembl:ENST00000457879|rcsb pdb:4I48|go:"GO:0042605"(peptide antigen binding)|ensembl:ENSG00000235657|ensembl:ENSP00000403575|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR036179|interpro:IPR037055|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0006955"(immune response)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|mint:MINT-8144494(identity) refseq:NP_004615.2|refseq:NP_001238812.1|refseq:NP_001238811.1|refseq:NP_001238813.1|refseq:NP_001238814.1|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001571(GPCR, family 2, vasoactive intestinal peptide receptor)|interpro:IPR001771(GPCR, family 2, vasoactive intestinal peptide receptor 1)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3DTX|rcsb pdb:3HCV|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:6VN7|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|go:"GO:0043235"(receptor complex)|ensembl:ENSG00000114812(gene)|ensembl:ENST00000325123(transcript)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|refseq:XP_005265495.1|refseq:XP_011532381.1|mint:MINT-8144495(identity) - no-uniprot-update: - comment:homomint|comment:mint|figure legend:f2 f3 f4 f5 t1 sf1|comment:"infrared spectroscopy (MI:0964) study with the extra-cellular domains of B*2705 and B*2709 as well as 13C-labeled beta2m in complex with citrulline-modified peptide pVIPR-U5 (RRKWURWHL; U = citrulline) and nonapeptide pVIPR. The IR data of B*2709/13C-beta2m:pVIPR and B*2705/13C-beta2m:pVIPR are from previous work by our group [27]."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/03/14 2019/11/12 rogid:r6UnYO31dZgh/h+E2JiAhAmKj2Y9606 rogid:DBdFfrPCE6B+JrkT9HLBrn09l0k9606 intact-crc:9E0E301DDAEAFA83|rigid:ZedRlvqerKITE4Nqz1R4dDKYDzU false binding-associated region:25-308(MINT-8144513) binding-associated region:400-408(MINT-8144517) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis)