#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BY76	uniprotkb:P63000	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843710|imex:IM-15743-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3K.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	intact-crc:7B407BB176F64371|rigid:uaPUiUHNAJoSaZdV1iMPkbj6sDE	false	-	biological feature:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BY76	uniprotkb:Q05397	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843710|imex:IM-15743-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3K.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:7B407BB176F64371|rigid:uaPUiUHNAJoSaZdV1iMPkbj6sDE	false	-	O4'-phospho-L-tyrosine:397-397	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BY76	uniprotkb:P18084	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843710|imex:IM-15743-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3K.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	intact-crc:7B407BB176F64371|rigid:uaPUiUHNAJoSaZdV1iMPkbj6sDE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BY76	uniprotkb:P18084	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843710|imex:IM-15743-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3K.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	intact-crc:7B407BB176F64371|rigid:uaPUiUHNAJoSaZdV1iMPkbj6sDE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BY76	uniprotkb:P05556	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843401|imex:IM-15743-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs 3E, 3G.|comment:"The KD was determined to be  \"about 10−7 M\"."|antagonist:mAb11F6C4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:13FB0C9F28377B5C|rigid:hxsCd0rOibcTbMWcaTLeDd8GyNw	false	his tag:n-n|sufficient binding region:179..179-401..401	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BY76	uniprotkb:P18084	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843641|imex:IM-15743-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs 3F, 3H.|comment:"The KD was determined to be  \"about 10−7 M\"."|antagonist:mAb11F6C4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	intact-crc:BB3DF1DC5B275F42|rigid:Uj34kW/EEjyQXRs2+MUFcff169M	false	his tag:n-n|sufficient binding region:179..179-401..401	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05556	uniprotkb:Q9BY76	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:"MI:0813"(proximity ligation assay)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843841|imex:IM-15743-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3I, S3I.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	intact-crc:FEE37E774B443CAA|rigid:hxsCd0rOibcTbMWcaTLeDd8GyNw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BY76	uniprotkb:P18084	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Zhu et al. (2011)	pubmed:21397862|imex:IM-15743	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3843852|imex:IM-15743-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3I, S3I.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a5rt3)|taxid:9606(Human metastatic skin  keratinocyte cell line ,  A5RT3 or A-5RT3.)	kd:1.0x10^-7(molar)	2011/03/18	2014/10/16	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	intact-crc:CC1468FC9B0C72B9|rigid:Uj34kW/EEjyQXRs2+MUFcff169M	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)