#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8K4V6	uniprotkb:P04629	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-1028226|uniprotkb:P08119|uniprotkb:Q15655|uniprotkb:Q15656|uniprotkb:Q5D056|uniprotkb:Q5VZS2|uniprotkb:Q7Z5C3|uniprotkb:Q9UIU7|uniprotkb:B2R6T5|uniprotkb:B7ZM34|ensembl:ENSP00000431418	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk1_human(display_long)|uniprotkb:NTRK1(gene name)|psi-mi:NTRK1(display_short)|uniprotkb:TRK(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:TRK1-transforming tyrosine kinase protein(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:MTC(gene name synonym)|uniprotkb:TRKA(gene name synonym)|uniprotkb:Tropomyosin-related kinase A(gene name synonym)|uniprotkb:Tyrosine kinase receptor(gene name synonym)|uniprotkb:Tyrosine kinase receptor A(gene name synonym)|uniprotkb:gp140trk(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602543|mint:MINT-8178353|imex:IM-15411-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178355(identity)	refseq:NP_001007793.1|refseq:NP_001012331.1|refseq:NP_002520.2|ensembl:ENSG00000198400(gene)|ensembl:ENST00000524377(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|interpro:IPR040665|mint:P04629|rcsb pdb:1HE7|rcsb pdb:1SHC|rcsb pdb:1WWA|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:2N90|rcsb pdb:4AOJ|rcsb pdb:4CRP|rcsb pdb:4F0I|rcsb pdb:4GT5|rcsb pdb:4PMM|rcsb pdb:4PMP|rcsb pdb:4PMS|rcsb pdb:4PMT|rcsb pdb:4YNE|rcsb pdb:4YPS|rcsb pdb:5H3Q|rcsb pdb:5I8A|rcsb pdb:5JFS|rcsb pdb:5JFV|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5JFX|rcsb pdb:5KMI|rcsb pdb:5KMJ|rcsb pdb:5KMK|rcsb pdb:5KML|rcsb pdb:5KMM|rcsb pdb:5KMN|rcsb pdb:5KMO|rcsb pdb:5KVT|rcsb pdb:5WR7|rcsb pdb:6D1Y|rcsb pdb:6D1Z|rcsb pdb:6D20|rcsb pdb:6D22|rcsb pdb:6DKB|rcsb pdb:6DKG|rcsb pdb:6DKI|rcsb pdb:6DKW|rcsb pdb:6IQN|rcsb pdb:6J5L|rcsb pdb:6NPT|rcsb pdb:6NSP|rcsb pdb:6NSS|rcsb pdb:6PL1|rcsb pdb:6PL2|rcsb pdb:6PL3|rcsb pdb:6PL4|rcsb pdb:6PMA|rcsb pdb:6PMB|rcsb pdb:6PMC|rcsb pdb:6PME|reactome:R-HSA-167021|reactome:R-HSA-167044|reactome:R-HSA-170968|reactome:R-HSA-170984|rcsb pdb:5JFW|reactome:R-HSA-177504|reactome:R-HSA-187024|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-198203|reactome:R-HSA-198745|dip:DIP-5714N|mint:MINT-8178357(identity)	-	comment:mint	-	figure legend:f1d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:23wX9uYjIrxsAIcCHQ1IYMsICmw9606	intact-crc:3A387C14B07191DE|rigid:wAJHzseds88xjdBswdcOigxK/Q0	false	-	ha tag:?-?(MINT-8178358)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63604	uniprotkb:Q8K4V6	intact:EBI-7287667|intact:MINT-1204365|uniprotkb:Q63606|uniprotkb:Q63605|ensembl:ENSRNOP00000045635	intact:EBI-8602514|intact:MINT-8177761	psi-mi:ntrk2_rat(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602529|mint:MINT-8178329|imex:IM-15411-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3213|refseq:NP_001156640.1|refseq:NP_036863.1|ensembl:ENSRNOG00000018839(gene)|ensembl:ENSRNOT00000042145(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0009416"(response to light stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0009986"(cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043195"(terminal bouton)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0014047"(glutamate secretion)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098794"(postsynapse)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q63604|reactome:R-RNO-9026527|reactome:R-RNO-9028731|reactome:R-RNO-9032759|dip:DIP-5717N|mint:MINT-8178333(identity)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178331(identity)	-	function:"Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1"|comment:mint	comment:mint	figure legend:f1b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/04/27	2014/10/16	rogid:0ft2yR2N4GNlpCk07AUqHGE81XU10116	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	intact-crc:B7EB82E377971C5D|rigid:fv60mHjtR0eWUNqGwOH3TB46oYA	false	ha tag:?-?(MINT-8178334)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:Q63604	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-7287667|intact:MINT-1204365|uniprotkb:Q63606|uniprotkb:Q63605|ensembl:ENSRNOP00000045635	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_rat(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602557|mint:MINT-8178366|imex:IM-15411-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178368(identity)	rgd:3213|refseq:NP_001156640.1|refseq:NP_036863.1|ensembl:ENSRNOG00000018839(gene)|ensembl:ENSRNOT00000042145(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0009416"(response to light stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0009986"(cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043195"(terminal bouton)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0014047"(glutamate secretion)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098794"(postsynapse)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q63604|reactome:R-RNO-9026527|reactome:R-RNO-9028731|reactome:R-RNO-9032759|dip:DIP-5717N|mint:MINT-8178370(identity)	-	comment:mint	function:"Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1"|comment:mint	figure legend:f1g|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:0ft2yR2N4GNlpCk07AUqHGE81XU10116	intact-crc:A97F1630EFE5435A|rigid:fv60mHjtR0eWUNqGwOH3TB46oYA	false	myc tag:?-?(MINT-8178377)	ha tag:?-?(MINT-8178371)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8K4V6	uniprotkb:P35235	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602619|mint:MINT-8178506|imex:IM-15411-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178508(identity)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-8178511(identity)	-	comment:mint	-	figure legend:f2a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2020/01/07	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:1B03672979554AAE|rigid:Fgcb0jiG5KZzS/9hNAfGpJ1cW5A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P35235	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602630|mint:MINT-8178842|imex:IM-15411-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178844(identity)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-8178846(identity)	-	comment:mint	-	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2020/01/07	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:7981E3EB3F7B232B|rigid:Fgcb0jiG5KZzS/9hNAfGpJ1cW5A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35235	uniprotkb:P15209	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602584|mint:MINT-8173717|imex:IM-15411-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-8173720(identity)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8173719(identity)	-	-	-	figure legend:f2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2020/01/07	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	intact-crc:F1BB24CA1BC7C966|rigid:sjIyM8KHxnS4I7DNHDjatOv5ppM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P15209	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602608|mint:MINT-8178397|imex:IM-15411-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178399(identity)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8178401(identity)	-	comment:mint	-	comment:mint|figure legend:f1i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	intact-crc:A0A09E288A6AD962|rigid:tWqHiMFv1kzHpBWIxap7HECh9OQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P15209	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602597|mint:MINT-8178382|imex:IM-15411-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178384(identity)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8178388(identity)	-	comment:mint	-	comment:mint|figure legend:f1h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	intact-crc:C2221AEACC44B26D|rigid:tWqHiMFv1kzHpBWIxap7HECh9OQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P15209	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602641|mint:MINT-8179138|imex:IM-15411-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8179140(identity)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8179142(identity)	-	comment:mint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2020/01/07	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	intact-crc:8C82314545F138C9|rigid:1YOS4jdzXISW8hO43lQ+2vXReIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P35235	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602641|mint:MINT-8179138|imex:IM-15411-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8179140(identity)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-8179147(identity)	-	comment:mint	-	figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2011/04/27	2020/01/07	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:8C82314545F138C9|rigid:1YOS4jdzXISW8hO43lQ+2vXReIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:Q63604	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-7287667|intact:MINT-1204365|uniprotkb:Q63606|uniprotkb:Q63605|ensembl:ENSRNOP00000045635	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_rat(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602665|mint:MINT-8178317|imex:IM-15411-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178320(identity)	rgd:3213|refseq:NP_001156640.1|refseq:NP_036863.1|ensembl:ENSRNOG00000018839(gene)|ensembl:ENSRNOT00000042145(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0009416"(response to light stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0009986"(cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043195"(terminal bouton)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0014047"(glutamate secretion)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098794"(postsynapse)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q63604|reactome:R-RNO-9026527|reactome:R-RNO-9028731|reactome:R-RNO-9032759|dip:DIP-5717N|mint:MINT-8178319(identity)	-	comment:mint	function:"Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1"|comment:mint	figure legend:f1a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:0ft2yR2N4GNlpCk07AUqHGE81XU10116	intact-crc:82F43899FC273EC6|rigid:fv60mHjtR0eWUNqGwOH3TB46oYA	false	-	ha tag:?-?(MINT-8178325)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8K4V6	uniprotkb:P04629	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-1028226|uniprotkb:P08119|uniprotkb:Q15655|uniprotkb:Q15656|uniprotkb:Q5D056|uniprotkb:Q5VZS2|uniprotkb:Q7Z5C3|uniprotkb:Q9UIU7|uniprotkb:B2R6T5|uniprotkb:B7ZM34|ensembl:ENSP00000431418	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk1_human(display_long)|uniprotkb:NTRK1(gene name)|psi-mi:NTRK1(display_short)|uniprotkb:TRK(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:TRK1-transforming tyrosine kinase protein(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:MTC(gene name synonym)|uniprotkb:TRKA(gene name synonym)|uniprotkb:Tropomyosin-related kinase A(gene name synonym)|uniprotkb:Tyrosine kinase receptor(gene name synonym)|uniprotkb:Tyrosine kinase receptor A(gene name synonym)|uniprotkb:gp140trk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602679|mint:MINT-8178342|imex:IM-15411-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178344(identity)	refseq:NP_001007793.1|refseq:NP_001012331.1|refseq:NP_002520.2|ensembl:ENSG00000198400(gene)|ensembl:ENST00000524377(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|interpro:IPR040665|mint:P04629|rcsb pdb:1HE7|rcsb pdb:1SHC|rcsb pdb:1WWA|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:2N90|rcsb pdb:4AOJ|rcsb pdb:4CRP|rcsb pdb:4F0I|rcsb pdb:4GT5|rcsb pdb:4PMM|rcsb pdb:4PMP|rcsb pdb:4PMS|rcsb pdb:4PMT|rcsb pdb:4YNE|rcsb pdb:4YPS|rcsb pdb:5H3Q|rcsb pdb:5I8A|rcsb pdb:5JFS|rcsb pdb:5JFV|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5JFX|rcsb pdb:5KMI|rcsb pdb:5KMJ|rcsb pdb:5KMK|rcsb pdb:5KML|rcsb pdb:5KMM|rcsb pdb:5KMN|rcsb pdb:5KMO|rcsb pdb:5KVT|rcsb pdb:5WR7|rcsb pdb:6D1Y|rcsb pdb:6D1Z|rcsb pdb:6D20|rcsb pdb:6D22|rcsb pdb:6DKB|rcsb pdb:6DKG|rcsb pdb:6DKI|rcsb pdb:6DKW|rcsb pdb:6IQN|rcsb pdb:6J5L|rcsb pdb:6NPT|rcsb pdb:6NSP|rcsb pdb:6NSS|rcsb pdb:6PL1|rcsb pdb:6PL2|rcsb pdb:6PL3|rcsb pdb:6PL4|rcsb pdb:6PMA|rcsb pdb:6PMB|rcsb pdb:6PMC|rcsb pdb:6PME|reactome:R-HSA-167021|reactome:R-HSA-167044|reactome:R-HSA-170968|reactome:R-HSA-170984|rcsb pdb:5JFW|reactome:R-HSA-177504|reactome:R-HSA-187024|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-198203|reactome:R-HSA-198745|dip:DIP-5714N|mint:MINT-8178346(identity)	-	comment:mint	-	figure legend:f1c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/04/27	2014/10/16	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:23wX9uYjIrxsAIcCHQ1IYMsICmw9606	intact-crc:3652915C0789E295|rigid:wAJHzseds88xjdBswdcOigxK/Q0	false	-	ha tag:?-?(MINT-8178347)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8K4V6	uniprotkb:P20917	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-774926|uniprotkb:P16880|uniprotkb:A0A087WPR1|ensembl:ENSMUSP00000139881	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:mag_mouse(display_long)|uniprotkb:Siglec-4a(gene name synonym)|uniprotkb:Mag(gene name)|psi-mi:Mag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602702|mint:MINT-8178407|imex:IM-15411-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178409(identity)	refseq:NP_001333015.1|refseq:NP_001333016.1|refseq:NP_034888.1|refseq:XP_011248743.1|refseq:NP_001333017.1|refseq:XP_017177497.1|refseq:NP_001333013.1|refseq:NP_001333014.1|refseq:XP_006539653.1|refseq:XP_006539654.1|refseq:XP_011248740.1|refseq:XP_011248741.1|refseq:XP_011248742.1|refseq:XP_017177496.1|ensembl:ENSMUSG00000036634(gene)|ensembl:ENSMUST00000191081(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097453"(mesaxon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P20917|rcsb pdb:5LF5|rcsb pdb:5LFR|rcsb pdb:5LFU|rcsb pdb:5LFV|rcsb pdb:6GZJ|rcsb pdb:6GZL|reactome:R-MMU-193634|reactome:R-MMU-210991|mint:MINT-8178415(identity)	-	comment:mint	-	comment:homomint|comment:mint|figure legend:f1j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2011/04/27	2019/09/20	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:sgxaYqIU4i2tAdeRMT9/UqKO0Qo10090	intact-crc:835A3C29654A71A6|rigid:xhhgY2Ceq0reAsn15C3yNz7TAwQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4V6	uniprotkb:P15209	intact:EBI-8602514|intact:MINT-8177761	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	psi-mi:q8k4v6_mouse(display_long)|uniprotkb:Pirb(gene name)|psi-mi:Pirb(display_short)|uniprotkb:Lilrb3(gene name synonym)	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602702|mint:MINT-8178407|imex:IM-15411-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|rcsb pdb:6GRQ|rcsb pdb:6GRS|rcsb pdb:6GRT|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013151(Immunoglobulin)|mint:Q8K4V6|interpro:IPR036179|mint:MINT-8178409(identity)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8178411(identity)	-	comment:mint	-	comment:homomint|comment:mint|figure legend:f1j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2011/04/27	2019/09/20	rogid:/eQLOdZREiqMAREzyQV5f80eeAM10090	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	intact-crc:835A3C29654A71A6|rigid:xhhgY2Ceq0reAsn15C3yNz7TAwQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15209	uniprotkb:P35235	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602726|mint:MINT-8179154|imex:IM-15411-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8179158(identity)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-8179160(identity)	-	-	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/27	2020/01/07	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:7BE6D14011D37D25|rigid:WWOV2kg7lyBUwF45rj1FWJPRmPI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15209	uniprotkb:P04629	intact:EBI-309647|uniprotkb:Q3TUF9|uniprotkb:Q80WU0|uniprotkb:Q91XJ9|ensembl:ENSMUSP00000078757|ensembl:ENSMUSP00000153553	intact:EBI-1028226|uniprotkb:P08119|uniprotkb:Q15655|uniprotkb:Q15656|uniprotkb:Q5D056|uniprotkb:Q5VZS2|uniprotkb:Q7Z5C3|uniprotkb:Q9UIU7|uniprotkb:B2R6T5|uniprotkb:B7ZM34|ensembl:ENSP00000431418	psi-mi:ntrk2_mouse(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkB/GP95-TrkB(gene name synonym)	psi-mi:ntrk1_human(display_long)|uniprotkb:NTRK1(gene name)|psi-mi:NTRK1(display_short)|uniprotkb:TRK(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:TRK1-transforming tyrosine kinase protein(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:MTC(gene name synonym)|uniprotkb:TRKA(gene name synonym)|uniprotkb:Tropomyosin-related kinase A(gene name synonym)|uniprotkb:Tyrosine kinase receptor(gene name synonym)|uniprotkb:Tyrosine kinase receptor A(gene name synonym)|uniprotkb:gp140trk(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Fujita et al. (2011)	mint:MINT-8173699|pubmed:21364532|imex:IM-15411|doi:10.1038/emboj.2011.55	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8602726|mint:MINT-8179154|imex:IM-15411-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269890.1|refseq:NP_001020245.1|refseq:NP_032771.1|refseq:XP_006517212.1|refseq:XP_006517215.1|go:"GO:0002020"(protease binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|ensembl:ENSMUSG00000055254(gene)|ensembl:ENSMUST00000079828(transcript)|ensembl:ENSMUST00000225488(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0043679"(axon terminus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0098794"(postsynapse)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:0043204"(perikaryon)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0043235"(receptor complex)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0043408"(regulation of MAPK cascade)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P15209|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|refseq:XP_017170909.1|refseq:XP_017170908.1|dip:DIP-5722N|mint:MINT-8179158(identity)	refseq:NP_001007793.1|refseq:NP_001012331.1|refseq:NP_002520.2|ensembl:ENSG00000198400(gene)|ensembl:ENST00000524377(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|interpro:IPR040665|mint:P04629|rcsb pdb:1HE7|rcsb pdb:1SHC|rcsb pdb:1WWA|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:2N90|rcsb pdb:4AOJ|rcsb pdb:4CRP|rcsb pdb:4F0I|rcsb pdb:4GT5|rcsb pdb:4PMM|rcsb pdb:4PMP|rcsb pdb:4PMS|rcsb pdb:4PMT|rcsb pdb:4YNE|rcsb pdb:4YPS|rcsb pdb:5H3Q|rcsb pdb:5I8A|rcsb pdb:5JFS|rcsb pdb:5JFV|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5JFX|rcsb pdb:5KMI|rcsb pdb:5KMJ|rcsb pdb:5KMK|rcsb pdb:5KML|rcsb pdb:5KMM|rcsb pdb:5KMN|rcsb pdb:5KMO|rcsb pdb:5KVT|rcsb pdb:5WR7|rcsb pdb:6D1Y|rcsb pdb:6D1Z|rcsb pdb:6D20|rcsb pdb:6D22|rcsb pdb:6DKB|rcsb pdb:6DKG|rcsb pdb:6DKI|rcsb pdb:6DKW|rcsb pdb:6IQN|rcsb pdb:6J5L|rcsb pdb:6NPT|rcsb pdb:6NSP|rcsb pdb:6NSS|rcsb pdb:6PL1|rcsb pdb:6PL2|rcsb pdb:6PL3|rcsb pdb:6PL4|rcsb pdb:6PMA|rcsb pdb:6PMB|rcsb pdb:6PMC|rcsb pdb:6PME|reactome:R-HSA-167021|reactome:R-HSA-167044|reactome:R-HSA-170968|reactome:R-HSA-170984|rcsb pdb:5JFW|reactome:R-HSA-177504|reactome:R-HSA-187024|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-198203|reactome:R-HSA-198745|dip:DIP-5714N|mint:MINT-8179156(identity)	-	-	-	comment:homomint|figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/27	2020/01/07	rogid:NaGSeT7Pkwq8OE3rxvyTKEAU7mU10090	rogid:23wX9uYjIrxsAIcCHQ1IYMsICmw9606	intact-crc:7BE6D14011D37D25|rigid:WWOV2kg7lyBUwF45rj1FWJPRmPI	false	-	tag:?-?(MINT-8179167)|binding-associated region:484-497(MINT-8179169)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)