#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UKL3	uniprotkb:O75925	intact:EBI-2339650|uniprotkb:Q6PH76|uniprotkb:Q9NZV9|uniprotkb:Q86YD9|uniprotkb:Q9P2N1|uniprotkb:Q9NUQ4|uniprotkb:Q7LCQ7|uniprotkb:Q9Y563|uniprotkb:A2RUB7|uniprotkb:E1P553	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:c8ap2_human(display_long)|uniprotkb:CASP8AP2(gene name)|psi-mi:CASP8AP2(display_short)|uniprotkb:FLASH(gene name synonym)|uniprotkb:KIAA1315(gene name synonym)|uniprotkb:RIP25(gene name synonym)|uniprotkb:FLICE-associated huge protein(gene name synonym)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843421|imex:IM-17215-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001131139.1|refseq:NP_001131140.1|refseq:NP_036247.1|mint:Q9UKL3|dip:DIP-40986N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0016605"(PML body)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039674|rcsb pdb:2LR8|rcsb pdb:6ANO|rcsb pdb:6AOZ|rcsb pdb:6AP0|reactome:R-HSA-3899300	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:fig.1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/21	2014/10/16	rogid:MRT84GftrXoJmhrsnUtfJGFhPQQ9606	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	intact-crc:0AAE6CA233C18A82|rigid:p2HYXlgpnFWeCyCKY65Q9yvJqNY	false	sufficient binding region:1508-1982	sufficient binding region:1-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UKL3	uniprotkb:O75925	intact:EBI-2339650|uniprotkb:Q6PH76|uniprotkb:Q9NZV9|uniprotkb:Q86YD9|uniprotkb:Q9P2N1|uniprotkb:Q9NUQ4|uniprotkb:Q7LCQ7|uniprotkb:Q9Y563|uniprotkb:A2RUB7|uniprotkb:E1P553	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:c8ap2_human(display_long)|uniprotkb:CASP8AP2(gene name)|psi-mi:CASP8AP2(display_short)|uniprotkb:FLASH(gene name synonym)|uniprotkb:KIAA1315(gene name synonym)|uniprotkb:RIP25(gene name synonym)|uniprotkb:FLICE-associated huge protein(gene name synonym)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843437|imex:IM-17215-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001131139.1|refseq:NP_001131140.1|refseq:NP_036247.1|mint:Q9UKL3|dip:DIP-40986N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0016605"(PML body)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039674|rcsb pdb:2LR8|rcsb pdb:6ANO|rcsb pdb:6AOZ|rcsb pdb:6AP0|reactome:R-HSA-3899300	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:fig. 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/21	2014/10/16	rogid:MRT84GftrXoJmhrsnUtfJGFhPQQ9606	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	intact-crc:E971394A40640D72|rigid:p2HYXlgpnFWeCyCKY65Q9yvJqNY	false	sufficient binding region:1508-1982	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75925	uniprotkb:Q9UKL3	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	intact:EBI-2339650|uniprotkb:Q6PH76|uniprotkb:Q9NZV9|uniprotkb:Q86YD9|uniprotkb:Q9P2N1|uniprotkb:Q9NUQ4|uniprotkb:Q7LCQ7|uniprotkb:Q9Y563|uniprotkb:A2RUB7|uniprotkb:E1P553	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:c8ap2_human(display_long)|uniprotkb:CASP8AP2(gene name)|psi-mi:CASP8AP2(display_short)|uniprotkb:FLASH(gene name synonym)|uniprotkb:KIAA1315(gene name synonym)|uniprotkb:RIP25(gene name synonym)|uniprotkb:FLICE-associated huge protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843443|imex:IM-17215-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	refseq:NP_001131139.1|refseq:NP_001131140.1|refseq:NP_036247.1|mint:Q9UKL3|dip:DIP-40986N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0016605"(PML body)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039674|rcsb pdb:2LR8|rcsb pdb:6ANO|rcsb pdb:6AOZ|rcsb pdb:6AP0|reactome:R-HSA-3899300	-	-	-	figure legend:fig. 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/21	2014/10/16	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rogid:MRT84GftrXoJmhrsnUtfJGFhPQQ9606	intact-crc:8FA9CC9F71F54A8B|rigid:p2HYXlgpnFWeCyCKY65Q9yvJqNY	false	-	sufficient binding region:1-304	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10242	uniprotkb:O75925	intact:EBI-298355|uniprotkb:P78391|uniprotkb:P78392|uniprotkb:P78525|uniprotkb:P78526|uniprotkb:Q14023|uniprotkb:Q14024|uniprotkb:Q9UE83|uniprotkb:Q708E4|uniprotkb:Q708E7|ensembl:ENSP00000356788|uniprotkb:E9PNL6|uniprotkb:E9PI07|uniprotkb:E9PLZ5|uniprotkb:E9PNA4|uniprotkb:E9PRS2	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:myb_human(display_long)|uniprotkb:MYB(gene name)|psi-mi:MYB(display_short)|uniprotkb:Proto-oncogene c-Myb(gene name synonym)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843654|imex:IM-17215-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155129.1|refseq:NP_001155130.1|refseq:NP_001155131.1|refseq:NP_001155132.1|refseq:NP_001123644.1|refseq:NP_001123645.1|refseq:NP_005366.2|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000845"(positive regulation of testosterone secretion)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR012642(Mitotic Wos2)|interpro:IPR015395(C-myb, C-terminal)|interpro:IPR017930|mint:P10242|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000118513(gene)|ensembl:ENST00000367814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|refseq:NP_001155128.1|dip:DIP-1057N	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:fig. 4a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/21	2014/10/16	rogid:do/bvngcNTqnh1KZE4vDAtPP0749606	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	intact-crc:06770627FF5A2008|rigid:YtV+ty+5hY7PwpMGwJMZtpZHO5c	false	-	necessary binding region:502-651	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75925	uniprotkb:Q9UKL3	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	intact:EBI-2339650|uniprotkb:Q6PH76|uniprotkb:Q9NZV9|uniprotkb:Q86YD9|uniprotkb:Q9P2N1|uniprotkb:Q9NUQ4|uniprotkb:Q7LCQ7|uniprotkb:Q9Y563|uniprotkb:A2RUB7|uniprotkb:E1P553	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:c8ap2_human(display_long)|uniprotkb:CASP8AP2(gene name)|psi-mi:CASP8AP2(display_short)|uniprotkb:FLASH(gene name synonym)|uniprotkb:KIAA1315(gene name synonym)|uniprotkb:RIP25(gene name synonym)|uniprotkb:FLICE-associated huge protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843479|imex:IM-17215-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	refseq:NP_001131139.1|refseq:NP_001131140.1|refseq:NP_036247.1|mint:Q9UKL3|dip:DIP-40986N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0016605"(PML body)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039674|rcsb pdb:2LR8|rcsb pdb:6ANO|rcsb pdb:6AOZ|rcsb pdb:6AP0|reactome:R-HSA-3899300	-	-	-	figure legend:fig. 1d and fig. 2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/21	2014/10/16	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rogid:MRT84GftrXoJmhrsnUtfJGFhPQQ9606	intact-crc:ACDA52DAB96C5C46|rigid:p2HYXlgpnFWeCyCKY65Q9yvJqNY	false	flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1508-1982|sufficient binding region:1-304	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9WUF3	uniprotkb:O75925	intact:EBI-309915|uniprotkb:B1AX74|uniprotkb:Q9CSW2|ensembl:ENSMUSP00000029950|ensembl:ENSMUSP00000136016	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:c8ap2_mouse(display_long)|uniprotkb:Casp8ap2(gene name)|psi-mi:Casp8ap2(display_short)|uniprotkb:Flash(gene name synonym)|uniprotkb:FLICE-associated huge protein(gene name synonym)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Alm-Kristiansen et al. (2011)	pubmed:21338522|imex:IM-17215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3843525|imex:IM-17215-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116450.1|refseq:NP_036127.2|ensembl:ENSMUSG00000028282(gene)|ensembl:ENSMUST00000029950(transcript)|ensembl:ENSMUST00000178925(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016605"(PML body)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR039674|mint:Q9WUF3|reactome:R-MMU-3899300	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. 1g|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cv-1)|taxid:9534(Monkey African Green kidney fibroblast)	-	2011/03/21	2014/10/16	rogid:akJ3hcxS0u0cHChlBl1YQ1XSi+k10090	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	intact-crc:A3E52DCDCB5B9DD8|rigid:rK9gxN5aUMt3NxqlH8qvzbWOAQk	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)